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  • therapeutic
  • To identify cellular components whose targeted therapeutic inactivation could potentially enhance the sensitivity of treatment-resistant cancer cells to DNA-damaging therapies, we have chosen an unbiased genetic approach in live whole zebrafish embryos to identify genes that normally protect cells from the lethal effects of DNA damage. (plos.org)
  • Studies investigating the role of CAFs have reported that the therapeutic targeting of cancer cells alone is insufficient for the treatment of cancer ( 8 ). (spandidos-publications.com)
  • VEGF also exerts potent therapeutic effects in chemotherapy-induced sensory neuropathies, which have been attributed to its vessel growth and perfusion-promoting effects. (kuleuven.be)
  • To test whether the therapeutic effect of VEGF is due to a direct effect on sensory nerves, VEGF was subplantarly delivered to rats with Taxol-induced neuropathy. (kuleuven.be)
  • pathway
  • On prolonged cell cycle arrest, the intrinsic apoptotic pathway is activated, which is associated with the activation of the proapoptotic Bax that mediates the release of cytochrome c from mitochondria leading to the subsequent activation of the caspase cascade resulting in cell death ( 3 , 4 ). (aacrjournals.org)
  • Our results indicate that radiation and ABT-737 exert a synergistic effect on breast cancer cell lines through downregulating Mcl-1 and activating the bak-apoptotic pathway. (jove.com)
  • protein
  • Triggering of CD95 (Fas/APO-1) or other death receptors leads to the recruitment of the adaptor molecule Fas-associated death domain protein, which binds directly to the receptor death domain and recruits procaspase-8 to form a death-inducing signaling complex (DISC) 3 ( 5 ). (jimmunol.org)
  • The cFLIP/FLAME-1 protein, also called caspase homolog, Casper, caspase-like apoptosis regulatory protein, I-FLICE, MACH-related inducer of toxicity, and Usurpin, is structurally similar to caspase-8 as it contains two death effector domains and a caspase-like domain, but lacks the key residues for proteolysis, most notably the cysteine within the active site ( 7 ). (jimmunol.org)
  • This tumor-suppressor protein regulates apoptosis, cell cycle and metabolism. (nature.com)
  • While the exact events that determine how this decision is made are not well understood, it is clear that p53-mediated transcriptional induction of the BH3-only protein Puma is critical for IR-induced apoptosis - . (plos.org)
  • MG53 is a protein that is primarily expressed in muscles and helps protect muscle cells from damage. (sciencemag.org)
  • In this study, scientists identified a protein called heat shock factor-1 (HSF-1) as a likely source of chemotherapy-related heart damage in mice and cell cultures. (healthcanal.com)
  • In analyses using heart muscle cells from mice with and without activation of HSF-1, the researchers observed more activation of the MDR1 gene in cells lacking the HSF-1 protein compared to normal mouse heart cells. (healthcanal.com)
  • In addition, they demonstrated that the MDR1 gene prompted production of a protein on these heart cells' surface that actually pumped doxorubicin away from the cells. (healthcanal.com)
  • The researchers discovered that interplay in the heart cells between HSF-1 and another protein, NF-kB , could be traced to production of the protective gene. (healthcanal.com)
  • necrosis
  • Upon SLP vaccination, tumors were highly infiltrated with HPV-specific, tumor necrosis factor-α (TNFα)- and interferon-γ (IFNγ)-producing T cells. (aacrjournals.org)
  • mammalian cells
  • Notably, the IGF1R functions upstream of Ras and Akt in mammalian cells ( 3 - 6 ). (pnas.org)
  • In addition to ASM, at least three other sphingomyelinases have been described in mammalian cells that vary in their pH optimum and cofactor dependency. (wikisource.org)
  • The insulin-like growth factor (IGF) system exerts pleiotropic effects on mammalian cells. (biomedcentral.com)
  • antitumor
  • . In vivo neutralization of TNFα significantly reduced the antitumor responses induced by the combined treatment. (aacrjournals.org)
  • Here, we show that SLP vaccination can be safely combined with seven relevant chemotherapeutics without hampering the vaccine-induced antitumor response. (aacrjournals.org)
  • cycle arrest
  • For instance, DNA-damaging drugs (e.g., topoisomerase inhibitors, cisplatin, etc.) activate the DNA damage checkpoint involving the function of the tumor suppressor p53, which contributes to a cell cycle arrest in G 1 and G 2 . (aacrjournals.org)
  • For instance, after DNA injury, p53 is activated promoting cell cycle arrest, transactivation of repairing enzymes and, if the damage cannot be repaired, apoptosis. (nature.com)
  • Immediate cell cycle arrest following DNA DSBs plays a critical role in promoting efficient DNA repair before cells enter mitosis. (plos.org)
  • anti-apoptotic
  • However, studies using cells derived from Niemann-Pick disease patients or from ASM knock-out mice revealed that the deficiency of this enzyme might also have beneficial consequences, including anti-apoptotic and cytoprotective effcts. (wikisource.org)
  • etoposide
  • Finally, short-term starvation provided complete protection to mice but not to injected neuroblastoma cells against a high dose of the chemotherapy drug/pro-oxidant etoposide. (pnas.org)
  • epithelial cells
  • In this study, we identified a novel regulatory mechanism in Hp -infected gastric epithelial cells by which Hp determines the subcellular localization of activated c-Abl to control Hp -mediated EMT-like processes while decreasing cell death. (springer.com)
  • Tumors that comprise a mass of malignant epithelial cells are also surrounded by multiple non-cancerous cell populations, including fibroblasts, endothelial cells, pericytes, immune regulatory cells and cytokines in the extracellular matrix (ECM) ( 1 ). (spandidos-publications.com)
  • clinical
  • Given that 100-dB noise is in the range of noise insults commonly experienced by people in our society, kenpaullone could have significant clinical application in treating noise-induced hearing loss," said the lead author, Jian Zuo from the St. Jude Children's Research Hospital. (yahoo.com)
  • The robust protection conferred by one-time local delivery of kenpaullone suggests that CDK2 inhibitors may transform the clinical prevention and treatment of cisplatin - and noise-induced hearing loss in patients," Zuo said in a paper published in the Journal of Experimental Medicine. (yahoo.com)
  • neurons
  • The positive effects of VEGF were counteracted by TSA and Tubacin, which suggests that VEGF protects sensory neurons in these Taxol models at least partly via HDAC6. (kuleuven.be)
  • molecules
  • The tumor antigens are processed and presented as peptides by major histocompatability complex (MHC) I and II molecules on the cell surface, and recognized by the T-cell receptor on T-cells. (biomedcentral.com)
  • This signal involves the ligation of CD28 or CTLA-4 on lymphocytes by co-stimulatory molecules CD80 (B7.1) or CD86 (B7.2) respectively on antigen presenting cells or target cells. (biomedcentral.com)
  • induction
  • Synergistic effect of CTLA-4 blockade and cancer chemotherapy in the induction of anti-tumor immunity. (carbocation.com)
  • Gut microbiota can promote the development and progression of CRC by different processes, including the induction of a chronic inflammatory state or immune response, altering stem cell dynamics, the biosynthesis of toxic and genotoxic metabolites, and affecting the host metabolism [20, (deepdyve.com)
  • Moreover
  • Moreover, RT-qPCR data showed that miR-195 is down-regulated while PHB1 is up-regulated in a collection of melanoma cells. (biomedcentral.com)
  • viability
  • In addition, Bcl-XL provided significantly greater cell viability than Bcl-2 against methotrexate, fluorouracil, and hydroxyurea, three S-phase specific agents. (bloodjournal.org)
  • In HEI-OC1 auditory cells, GB concentration-dependently inhibited the reduction of cell viability and increase in apoptosis exerted by cisplatin. (springer.com)
  • cancer cell death
  • A 2001 study conducted at the Toya Medical and Pharmaceutical University in Japan found that Maitake polysaccharides increased the killing power of macrophage immune cells, and another study by researchers at the New York Medical College, found that beta-glucan, a polysaccharide from Maitake, drastically slowed the growth of Prostate cancer cells, causing a nearly complete cancer cell death . (blogspot.com)