• As the scientists increased the CQA concentration, cancer cells died as a result of apoptosis. (sciencedaily.com)
  • The ability to induce apoptosis, or cell death, is a promising tactic for therapeutic interventions in all types of cancer, she said. (sciencedaily.com)
  • Abnormal metabolism and the evasion of apoptosis are considered hallmarks of cancers. (hindawi.com)
  • A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. (hindawi.com)
  • In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. (hindawi.com)
  • We do that primarily through a process called apoptosis-pre-programmed cell death, from the Greek ptosis , meaning falling, and apo , meaning away from. (nutritionfacts.org)
  • Then, apoptosis kicks in, and the cells in the webbing in between kill themselves off to separate our fingers. (nutritionfacts.org)
  • Interestingly, chloroquine-induced cell death was not dependent on caspase-mediated apoptosis, as neither overexpression of the antiapoptotic protein Bcl-2 nor deletion of the proapoptotic Bax and Bak affected chloroquine-induced MEF death. (jci.org)
  • Thus chloroquine induces lysosomal stress and provokes a p53-dependent cell death that does not require caspase-mediated apoptosis. (jci.org)
  • Many cancer therapies aim to trigger apoptosis in cancer cells. (muni.cz)
  • Although much is known about apoptosis, therapeutic opportunities of other cell death pathways are often neglected. (muni.cz)
  • Effects of RAD001 and letrozole (alone and in combination) on the proliferation and survival of MCF7/Aro and T47D/Aro cells were evaluated using proliferation assays, flow cytometry, immunoblotting, and apoptosis analyses. (aacrjournals.org)
  • Inhibition of Ser46 phosphorylation by targeting HIPK2, PKCδ, or ATM kinases, as well as inhibition of Pin1, prevented mHtt-dependent apoptosis of neuronal cells. (units.it)
  • PL was described as an anticancer compound modulating apoptosis, ROS production, cell proliferation, migration and invasion, and showing selective cytotoxic effect on several cancer cell types including pancreatic, renal, prostate, and breast cancers. (oncotarget.com)
  • Furthermore, with the aim of understanding the different cells' pathways involved in the toxicity and the final death of the cells, these hybrid system will be evaluated to investigate pathway-specific ROS/RNS induction of apoptosis and ROS-response mechanisms. (europa.eu)
  • In our previous studies, we showed that bitter melon extract (BME) exerts a strong anti-proliferative effect by inducing caspase-dependent apoptosis in breast cancer cells [ 6 ], although the in vivo effect of BME was not examined in breast cancer model. (oncotarget.com)
  • As a soluble, zinc-coordinated homotrimeric protein, it has emerged as a promising candidate for cancer therapy through its capacity to trigger apoptosis in many types of cancers without causing significant toxicity to normal cells [ 7 , 8 ]. (biomedcentral.com)
  • Consistent with this notion, a study examining apoptosis in individual cells has demonstrated that differences in the extent of caspase-8 activation may be responsible for the cell-to-cell variation in Apo2L/TRAIL responsiveness [ 16 ]. (biomedcentral.com)
  • HIC was able to arrest the cell cycle at G1/S phase and also induced apoptosis and DNA damage, validated by gene expression profiling. (tuni.fi)
  • Towards this goal, we identified a series of mitotically acting piperazine-based compounds that sensitized colon cancer cells to TNF-dependent apoptosis. (uconn.edu)
  • Further study of the activity of AK301 showed that p53-normal colon cancer cells efficiently underwent apoptosis in the absence of death ligands following release from their mitotic arrest. (uconn.edu)
  • Study of this effect indicated that AK301-treated cells showed high levels of ATM signaling during mitotic arrest and exit from mitosis, following compound withdrawal, resulted in a p53-dependent apoptosis. (uconn.edu)
  • Understanding the mechanisms cancer cells use to suppress apoptosis may ultimately facilitate in the development of novel approaches to colon cancer treatment and prevention. (uconn.edu)
  • These pro- has been implicated as contributing apoptosis, inflammation, and several liferating cel s replace dead cel s to the cancer phenotype, through pleiotropic responses. (who.int)
  • Sesquiterpene lactones containing a 3-methylenedihydrofuran-2(3H)-one (or α-methylene-γ-lactone) moiety, for example damsin (1), are Michael acceptors that affect biological processes such as cell proliferation, death/apoptosis, and cell migration, by interfering with cell signalling pathways. (lu.se)
  • Lipids, amino acids, and nucleotides necessary for the biosynthesis of the daughter cells are mostly provided by intermediate metabolites of these pathways. (hindawi.com)
  • To prevent aberrant cell proliferation, these pathways are tightly regulated. (hindawi.com)
  • There are built-in signaling pathways that cells use to sense transcriptional fidelity. (umassmed.edu)
  • However, when both apoptotic and autophagic pathways were blocked simultaneously, chloroquine-induced killing of Myc-overexpressing cells was blunted. (jci.org)
  • Luckily, scientific consensus describes about 10 different cell death subroutines with different regulatory pathways and cancer cells are probably not able to avoid all of cell death types at once. (muni.cz)
  • The large proportion of this clinical heterogeneity probably lies in alterations of cell death pathways. (muni.cz)
  • If you better understand precisely how cancer cells that are potentially metastatic survive in these sorts of foreign environments, then you can potentially antagonize those survival pathways and selectively cause those cells to die," said Schafer, also an affiliate member of Notre Dame's Harper Cancer Research Institute. (medicalxpress.com)
  • On these premises, we were prompted to investigate the signalling pathways and protein interactions that modulate p53 activation in both cancer and neurodegeneration with the aim of identifying critical hubs as new targets for therapeutic intervention. (units.it)
  • Moreover, a therapeutic effect can also be achieved by targeting and inducing multiple pathways of programmed cell death. (foxchase.org)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Furthermore, certain signalling pathways will be studied to better understand the different cellular pathways involved in the toxicity and final death of the cells. (europa.eu)
  • Colon cancers harbor a variety of mutations that result in uncontrolled proliferation and suppression of apoptotic pathways. (uconn.edu)
  • A number of direct and indirect radiation interaction pathways can produce damage to the DNA of irradiated cells. (cdc.gov)
  • Dendritic cells appear to develop in several pathways. (medscape.com)
  • Importantly, the regulatory functions of 4 DEmiRNAs and 3 verified target genes on cell proliferation and migration were explored in TNBC cell lines. (nature.com)
  • Cell proliferation involves the replication of all cellular contents with the required energy for this to happen. (hindawi.com)
  • This activation is necessary for both cell proliferation as well as glucose uptake and use. (hindawi.com)
  • Many breast cancers are dependent for proliferation on estrogens synthesized from androgens (i.e., androstenedione) by aromatase. (aacrjournals.org)
  • The role of the mTOR pathway in estrogen-driven proliferation and effects of combining RAD001 and letrozole were examined in vitro in two breast cancer models. (aacrjournals.org)
  • A vast amount of research exists on the possible molecular mechanisms through which vitamin D affects cancer cell proliferation, cancer progression, angiogenesis, and inflammation. (mdpi.com)
  • The effects of PL on cell proliferation, cell death and cell cycle were investigated. (oncotarget.com)
  • Upon its transition to the precancerous Barrett's esophagus epithelium, however, a small dedicated stem cell compartment appears that supports proliferation of the epithelium while concomitantly evidence for a stochastically dividing compartment contributing to the maintenance of the tissue disappears. (wikipedia.org)
  • Methods and results: Here, to outline the inhibitory role of HIC on prostate cancer cells, PC-3 and DU145 cell lines were treated with the respective IC50 concentrations, which reduced cell proliferation, adherence properties and spheroid formation. (tuni.fi)
  • Each category of histiocytosis can be traced to reactive or neoplastic proliferation in one of these cell lineages. (medscape.com)
  • In response to mito- pendence between the key mecha- gens, cell proliferation is triggered by nistic characteristics. (who.int)
  • H - Ras cell proliferation are also linked with haematopoietic cel s. (who.int)
  • However, cancer cells overcome these controls, in particular by acquiring genetic mutations leading to the activation of oncogenes (pten, myc) or loss of tumor suppressors (p53) [ 1 ]. (hindawi.com)
  • Cancer cells are acquiring mutations that allow them to sense and respond to their environment differently than normal cells. (umassmed.edu)
  • A new study published in Nature Communications by researchers at the University of California San Diego has found that gel manicures lead to "cell death and cancer-causing mutations in human cells," according to phys.org . (boingboing.net)
  • Exposure to the UV light also caused mitochondrial and DNA damage in the remaining cells and resulted in mutations with patterns that can be observed in skin cancer in humans. (boingboing.net)
  • We looked at patients with skin cancers, and we see the exact same patterns of mutations in these patients that were seen in the irradiated cells. (boingboing.net)
  • This cell model suggests these mutations could occur to any cell in the body resulting in a cancer. (wikipedia.org)
  • According to the "stochastic model" (or "clonal evolution model") every cancer cell in a tumor could gain the ability to self-renew and differentiate to the numerous and heterogeneous lineages of cancer cells that compromise a tumor These mutations could progressively accumulate and enhance the resistance and fitness of cells that allow them to outcompete other tumor cells, better known as the somatic evolution model. (wikipedia.org)
  • Activating mutations upstream may also underlie some epigenetic or within the ERK1/2 cascade are events that change cell signalling. (who.int)
  • Accumulating studies have suggested that miRNAs are frequently dysregulated in tumors compared with normal tissues, resulting in aberrant expression of target genes or proteins and cancer progression 13 . (nature.com)
  • This strategy is beneficial for the treatment of heterogeneous tumors and its microenvironment, since inducing the cell death can cause a local anticancer response that is favorable to the patient and leads to a therapeutic effect. (foxchase.org)
  • Although the survival rate of patients with retinoblastoma is extremely high in developed countries, left untreated advanced tumors limit eye preservation and expose patients to risks of metastasis and death. (oncotarget.com)
  • Further, we observed the increased p62 accumulation, induction of autophagy and apoptotic cell death in tumors from BME-fed animals. (oncotarget.com)
  • Immune cells abundantly infiltrate tumors, creating a complex environment mediated by repetitive cycles of antitumor responses and immune evasion ( 1 ). (frontiersin.org)
  • In addition to TAMs, solid tumors are also infiltrated by immunosuppressive, immature myeloid progenitor cells, commonly referred to as monocytic or polymorphonuclear myeloid-derived suppressor cells (M/PMN-MDSC) ( 11 - 13 ). (frontiersin.org)
  • Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample. (wikipedia.org)
  • CSCs may generate tumors through the stem cell processes of self-renewal and differentiation into multiple cell types. (wikipedia.org)
  • Such cells are hypothesized to persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumors. (wikipedia.org)
  • In different tumor subtypes, cells within the tumor population exhibit functional heterogeneity and tumors are formed from cells with various proliferative and differentiation capacities. (wikipedia.org)
  • Hence, at least for certain neoplastic tissues, dedicated stem cell compartments maintain and enlarge the size of the transformed compartment The cancer stem cell model, also known as the Hierarchical Model proposes that tumors are hierarchically organized (CSCs lying at the apex (Fig. 3). (wikipedia.org)
  • Within the cancer population of the tumors there are cancer stem cells (CSC) that are tumorigenic cells and are biologically distinct from other subpopulations They have two defining features: their long-term ability to self-renew and their capacity to differentiate into progeny that is non-tumorigenic but still contributes to the growth of the tumor. (wikipedia.org)
  • Pembrolizumab is a humanized monoclonal antibody against programmed death 1 (PD-1) that has antitumor activity in advanced non-small-cell lung cancer (NSCLC), with increased activity in tumors that express programmed death ligand 1 (PD-L1). (nih.gov)
  • Experts are hopeful that future cancer drugs could boost the activity of these CD95 receptors to create a new weapon against cancer tumors, which have been treated historically with surgery, chemotherapy and radiation. (newsrollup.com)
  • Despite being decently successful in liquid tumors, such as leukemia spectrum cancers, long-term remission remains the biggest challenge for CAR T-cell therapies," Tushir-Singh told Fox News Digital in an email. (newsrollup.com)
  • The newly discovered "kill switch" could terminate tumor cells while also helping to make immunotherapies more effective - "a potential one-two punch against tumors," the release stated. (newsrollup.com)
  • With the current information, we researchers and doctors should screen potential cancer patients - who would be undergoing CAR-T therapy - to check for the comprehensive presence of Fas on their tumors," he went on. (newsrollup.com)
  • The most aggressive subtype is TNBC, lacking of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2), accounting for 15-20% of all breast cancers 5 . (nature.com)
  • FAS is a so-called death receptor, which activates the FAS-associated death domain, along with death receptor five, and death receptor four. (nutritionfacts.org)
  • AXL receptor tyrosine kinase is a mediator of cancer cell phenotypic plasticity and suppression of tumor immunity, and AXL expression is associated with drug resistance and diminished long-term survival in a wide range of malignancies, including NSCLC. (uib.no)
  • The DNA-dependent activator of interferonregulatory factors (DAI) protein recognize IAV genomic RNA and through the receptor-interacting serine/threonine-protein kinase 3 (RIPK3) and the lineage kinase domain-like (MLKL) protein pathway triggers cell death and inflammatory responses. (foxchase.org)
  • Background: (1-(2-hydroxy-5-nitrophenyl)(4-hydroxyphenyl)methyl)indoline-4-carbonitrile (HIC), an agonist of the P2Y1 receptor (P2Y1R), induces cell death in prostate cancer cells. (tuni.fi)
  • In this open-label, phase 3 trial, we randomly assigned 305 patients who had previously untreated advanced NSCLC with PD-L1 expression on at least 50% of tumor cells and no sensitizing mutation of the epidermal growth factor receptor gene or translocation of the anaplastic lymphoma kinase gene to receive either pembrolizumab (at a fixed dose of 200 mg every 3 weeks) or the investigator's choice of platinum-based chemotherapy. (nih.gov)
  • Scientists at the UC Davis Comprehensive Cancer Center in Sacramento, California, have identified a protein on the CD95 receptor that can "program" cancer cells to die, as detailed in a study published in the journal Cell Death & Differentiation last month. (newsrollup.com)
  • A receptor is a protein within a cell that receives and transmits signals. (newsrollup.com)
  • Immune-based therapies, such as CAR (chimeric antigen receptor) T-cell therapy, have shown promise for a subset of patients, but have had limited effectiveness against many cancer types. (newsrollup.com)
  • The most potent of these compounds, 1-(3-chlorophenyl)-4-(2-ethoxybenzoyl)piperazine or AK301, arrested cells in a mitotic state (EC 50 ≈ 115 nM) in which the TNF receptor was efficiently coupled to caspase-8 activation. (uconn.edu)
  • The research team has discovered a type of receptor - a protein, located on the surface of the AML stem cells - which sends out signals. (lu.se)
  • This receptor, called (IL1RAP), cannot be found on healthy blood stem cells, which opens up the possibility for a selective attack on the diseased stem cells using antibodies. (lu.se)
  • Studies have shown that by targeting antibodies against IL1RAP, they will attach themselves to the receptor, and thereby inhibit cell growth. (lu.se)
  • Once the antibody has become attached to the receptor, it activates the body's natural immune system and attracts killer cells that are part of our immune system. (lu.se)
  • The first signal may involve interaction between an MHC I-bound and/or MHC II-bound peptide on an APC with the T-cell receptor (TCRs) on the effector lymphocytes. (medscape.com)
  • For example, when a patient is examined for pancreatic cancer, a normal pancreas does not light up on PET scans. (ktfnews.com)
  • This explains why there is much epidemiological evidence that people with diabetes are more likely to develop cancer, especially breast, colon, prostate, liver, and pancreatic cancers. (ktfnews.com)
  • And, it's because curcumin can affect numerous mechanisms of cell death at the same time, it's "possible that cancer cells may not [easily] develop resistance to curcumin-induced cell death," like they do to most chemotherapy. (nutritionfacts.org)
  • This has the potential to eventually become a nontoxic treatment for B-cell lymphoma which does not involve chemotherapy," said Gordon, a co-corresponding author with Thaxton on the paper. (understandingnano.com)
  • In its pro-survival role, autophagy allows cancer cells to overcome cytotoxic stresses generated the cancer environment or cancer treatments such as chemotherapy and evade cell death. (tmc.edu)
  • Another mode of chemotherapy-related dormancy that also needs to be modeled in modern drug development is the enrichment of tumor initiating cells with successive rounds of treatment. (elsevierpure.com)
  • Although surgery and certain chemotherapy drugs reduce the risk of breast cancer recurrence in some women who are at risk of developing the metastatic disease or a recurrence, the adverse side effects limits their use [ 2 ]. (oncotarget.com)
  • And while I watched my sister go through the horrible lumpectomy, chemotherapy and radiation I had breast cancer at the same time? (cookandcraftwithlove.com)
  • In patients with advanced NSCLC and PD-L1 expression on at least 50% of tumor cells, pembrolizumab was associated with significantly longer progression-free and overall survival and with fewer adverse events than was platinum-based chemotherapy. (nih.gov)
  • Following verification of a stem-like signature (upregulated expression of stemness markers, resistance to chemotherapy, increased spheroid formation, and tumorigenesis capabilities despite inoculation of a small number of cells), we analyzed the interaction of these cells with macrophages via direct and indirect coculture assays. (springer.com)
  • Because cancer cells divide faster than normal cells, they are more affected by chemotherapy compared to healthy cells", explains Helena Ågerstam, cancer researchers at Lund University. (lu.se)
  • Because stem cells multiply slowly, chemotherapy does not have a sufficient impact on them, which explains why two-thirds of these patients relapse. (lu.se)
  • Ultimately cancer cells died with the induction of two specific enzymes, caspase-3 and caspase-8, de Mejia said. (sciencedaily.com)
  • Herein is described the unprecedented biological properties of platinum( II ) complexes relevant to induction of cancer cell death via manifesting such intermolecular interactions. (rsc.org)
  • Abnormal polyamine metabolism as a result of altered SAT1 activity has an adverse effect on cells through the induction of PCD. (nih.gov)
  • This project will evolve our previos studies with a microtubule inhibitor, discodermolide, to synthesize a series of novel analogues that have modifications of the lactone ring and diene moieties that we hypothesize influence tumor cell kill and senescence induction in cells. (elsevierpure.com)
  • The overall goal of this program is to select lead compounds that have: (A) a low propensity to induce senescence, (B) high induction of tumor cell death in chemorefractory cell types, such as tumor initiating cells, and (C) minimal toxicity, as determined from measures of cardiopulmonary function and histology, nerve conduction, and neuropsychology. (elsevierpure.com)
  • Taken together, our results demonstrate that BME treatment inhibits breast tumor growth, and this anti-tumor activity in breast cancer is, in part, mediated by induction of autophagy and modulation of the AMPK/mTOR pathway. (oncotarget.com)
  • These results established immunosuppressive myeloid cells in lymphoid organs as an HPV + cancer-induced means of circumventing tumor immunity that will require targeted abrogation to enable the induction of efficacious antitumor immune responses. (nih.gov)
  • Immunostaining and immunoblotting analyses of the autophagic markers p62 [in PCa tissue microarrays (TMAs) and PCa cell lines] and LC3 (in PCa cell lines), transmission electron microscopy, and GFP-mCherry-LC3 were used to study autophagy induction and flux. (biomedcentral.com)
  • In PC3 cells, inhibition of autophagy induction prevented p62 accumulation and hence caspase-8 activation. (biomedcentral.com)
  • Effective induction of antigen-specific T-cell responses requires interaction between the dendritic cells and T lymphocytes to prime the latter cells for expansion and subsequent immune responses. (medscape.com)
  • Irish and Mechanistic data have been in- formation related to cancer induction Doxie, 2014) . (who.int)
  • Chloroquine-induced cell death in primary MEFs and human colorectal cancer cells was dependent upon p53, but not upon the p53 modulators Atm or Arf. (jci.org)
  • Green synthesized silver nanoparticles using the plant-based reducing agent Matricaria chamomilla induce cell death in colorectal cancer cells. (bvsalud.org)
  • The antitumor activity of BME by oral feeding in breast cancer models suggested the high potential for a clinical application. (oncotarget.com)
  • Here, we illustrated that myeloid cells in K14HPV16/H2b mice possess potent immunosuppressive activity toward antigen-presenting cells and CD8 + T cells, dampening antitumor immunity. (nih.gov)
  • Myeloid innate immune cells, such as granulocytes, monocytes, macrophages and dendritic cells (DCs), play an important role in cancer-cell recognition, initiation of inflammation and antitumor responses ( 2 ). (frontiersin.org)
  • Hence, myeloid cells play a dual role in cancer as they can initiate antitumor responses and communicate with cells of the adaptive immune system, but also promote local inflammation leading to chronic cancer-associated inflammation ( 5 , 6 ). (frontiersin.org)
  • That's important because inflammation can trigger the steps of cancer progression, she said. (sciencedaily.com)
  • Accumulating evidence shows that cancer stem cells are key drivers of tumor formation, progression, and recurrence. (hindawi.com)
  • Oncotarget published " Piperlongumine promotes death of retinoblastoma cancer cells " which reported that while retinoblastoma initiation is triggered by the inactivation of both alleles of the retinoblastoma tumor suppressor gene in the developing retina, tumor progression requires additional epigenetic changes, retinoblastoma genomes being quite stable. (oncotarget.com)
  • Interestingly, the most primordial defense responses employed by myeloid cells against pathogens, such as complement activation, antibody-dependent cell cytotoxicity and phagocytosis, actually seem to favor cancer progression. (frontiersin.org)
  • In this review, we discuss how rudimentary defense mechanisms deployed by myeloid cells can promote tumor progression. (frontiersin.org)
  • Chronic inflammation, however, can initiate tumorigenesis and can drive cancer progression in some cancer types ( 3 , 4 ). (frontiersin.org)
  • This model suggests that only certain subpopulations of cancer stem cells have the ability to drive the progression of cancer, meaning that there are specific (intrinsic) characteristics that can be identified and then targeted to destroy a tumor long-term without the need to battle the whole tumor. (wikipedia.org)
  • Apart from CSCs, there are a myriad of factors and interactions between various cell types and the tumor microenvironment (TME) that ultimately affect CCA progression. (springer.com)
  • Indeed, PL toxicity in retinoblastoma cell lines was inhibited by a ROS scavenger N-acetyl-l-cysteine treatment. (oncotarget.com)
  • They have found a previously undetected trigger point on a naturally occurring "death protein" that helps the body get rid of unwanted or diseased cells. (medindia.net)
  • One specific protein may be a master regulator for changing how cancer cells consume nutrients from their environments, preventing cell death and increasing the likelihood the cancer could spread, a study from the University of Notre Dame has shown. (medicalxpress.com)
  • Schafer and collaborators found a protein called SGK1, known to be activated in a variety of cancer cell types, signals the cell to take up nutrients. (medicalxpress.com)
  • There are unique circumstances where the SGK1 protein is critically important, so there might be a vulnerability that researchers can target and alter the way the cells process their nutrients, said Schafer. (medicalxpress.com)
  • In this study, we observed that BME treatment induces autophagosome-bound Long chain 3 (LC3)-B and accumulates protein p62/SQSTM1 (p62) in breast cancer cells. (oncotarget.com)
  • Autophagy is an evolutionally conserved catabolic process in all eukaryotic cells and contributes to organelle turnover, protein degradation, and differentiation [ 7 , 8 ]. (oncotarget.com)
  • P2Y1R-targeted HIC affects p53, MAPK and NF-κB protein expression, thereby improving the p53 stabilization essential for G1/S arrest and cell death. (tuni.fi)
  • DeMarini, and Chapter 20, by Rice and cell death determine the size protein in several signal ing path- and Herceg). (who.int)
  • The study, published in Cell Reports , was completed in the laboratory of Zachary Schafer, the Coleman Foundation Associate Professor of Cancer Biology in the Department of Biological Sciences. (medicalxpress.com)
  • In a 2014 paper published in BMC Biology, American scientists showed that many cancer cells specifically choose glucose as their food and consume glucose 50 to 100 times faster than normal tissues. (ktfnews.com)
  • Improved understanding of the pathology of histiocytic disorders requires knowledge of the origins, biology, and physiology of the cells involved. (medscape.com)
  • In a recent study, scientists showed that human colon cancer cells die when they are exposed to the approximate number of bioactive compounds present in one cup of mate tea, which has long been consumed in South America for its medicinal properties. (sciencedaily.com)
  • Could preventing colon cancer be as simple as developing a taste for yerba mate tea? (sciencedaily.com)
  • The caffeine derivatives in mate tea not only induced death in human colon cancer cells, they also reduced important markers of inflammation," said Elvira de Mejia, a U of I associate professor of food chemistry and food toxicology. (sciencedaily.com)
  • In the in vitro study, de Mejia and former graduate student Sirima Puangpraphant isolated, purified, and then treated human colon cancer cells with caffeoylquinic acid (CQA) derivatives from mate tea. (sciencedaily.com)
  • But, because the colon and its microflora play a major role in the absorption and metabolism of caffeine-related compounds, the anti-inflammatory and anti-cancer effects of mate tea may be most useful in the colon. (sciencedaily.com)
  • We believe there's ample evidence to support drinking mate tea for its bioactive benefits, especially if you have reason to be concerned about colon cancer. (sciencedaily.com)
  • The scientists have already completed and will soon publish the results of a study that compares the development of colon cancer in rats that drank mate tea as their only source of water with a control group that drank only water. (sciencedaily.com)
  • It can also activate the death machine directly-as has been shown in lung cancer and colon cancer. (nutritionfacts.org)
  • This discovery appears to be broadly relevant across many different types of cancer, Schafer said, with research in this paper focused on breast and colon cancer cells grown in cultures under different conditions. (medicalxpress.com)
  • The initial objective of our work was to understand how colon cancer cells survive their inflammatory micro-environment, including high levels of TNF and other death ligands. (uconn.edu)
  • These findings could serve as a basis for the development of agents that target the molecular alterations in mutated colon cancer cells and augment the apoptotic actions of their inflammatory microenvironment, for robust activation of apoptotic signaling. (uconn.edu)
  • Scientists identified mechanisms governing immune cells, selectively removing troublemakers to reshape skin immunity. (medindia.net)
  • In vivo studies show that SCNPs not only kill cancer cells, but also boost an anticancer immunity. (cdc.gov)
  • Here we show that chloroquine, a drug that activates the stress-responsive Atm-p53 tumor-suppressor pathway, preferentially enhances the death of Myc oncogene-overexpressing primary mouse B cells and mouse embryonic fibroblasts (MEFs) and impairs Myc-induced lymphomagenesis in a transgenic mouse model of human Burkitt lymphoma. (jci.org)
  • Leveraging a transgenic mouse model of HPV-derived cancers, K14HPV16/H2b, we demonstrated that a potent nanoparticle-based E7 vaccine, but not a conventional "liquid" vaccine, induced E7 tumor antigen-specific CD8 + T cells in cervical tumor-bearing mice. (nih.gov)
  • More than 90 percent of cancer deaths are caused by metastasis of cancer cells from one location to another, Schafer said. (medicalxpress.com)
  • Cancer stem cells (CSCs) are thought to the underlying reason for cancer initiation, metastasis, and relapse. (springer.com)
  • Prostate stromal cells were cultured, and tissue digestion media containing AGR2 prepared from prostate primary cancer 10-076 CP and adenocarcinoma LuCaP 70CR xenograft were added. (nih.gov)
  • The control were tissue digestion media containing no AGR2 prepared from benign prostate 10-076 NP and small cell carcinoma LuCaP 145.1 xenograft. (nih.gov)
  • Here we investigated whether SQSTM1/p62 (p62) overexpression, as a marker of autophagic flux, was related to aggressiveness of human prostate cancer (PCa) and whether autophagy regulated the treatment response in sensitive but not resistant PCa cell lines. (biomedcentral.com)
  • Researchers in the United States followed 3,184 Americans aged 26 to 84 from 1991 to 2013 and found that higher juice intake increased the risk of prostate cancer by 58 percent and higher sugary drink intake increased the risk of obesity-related cancers by 59 percent in subjects with over-central obesity. (ktfnews.com)
  • However, the molecular mechanism behind the inhibition of HIC in prostate cancer remains elusive. (tuni.fi)
  • HIC inhibited the prostate cancer cells' migration and invasion, revealing its antimetastatic ability. (tuni.fi)
  • Conclusion: These findings provide an insight on the potential use of HIC, which remains the mainstay treatment for prostate cancer. (tuni.fi)
  • DESCRIPTION (provided by applicant): Senescence, an underappreciated cell dormancy phenotype that occurs upon treatment with many cytotoxic drugs, represents a new paradigm in drug development. (elsevierpure.com)
  • Patients with cervical cancer have poor dendritic cell functions, have weak cytotoxic lymphocyte responses, and demonstrate an accumulation of myeloid cells in the periphery. (nih.gov)
  • [ 15 ] The surface of the APC contains 2 peptide-binding proteins (ie, major histocompatability complex [MHC] classes I and II), which can stimulate cytotoxic T (T C ) cells, regulatory T (Treg) cells, and helper T (T H ) cells. (medscape.com)
  • In contrast, cancer cells shift their metabolism toward lactate production even in the presence of oxygen [ 4 ], partly through genetic modifications that stabilize the transcription factor Hypoxia Inducible Factor (HIF) involved in the adaptation of the cells to hypoxia, under nonhypoxic conditions as well as generating an adaptive response to the hypoxic microenvironment (Figure 1 ). (hindawi.com)
  • Nevertheless, the presence of oncogenic alterations in these cells and distorted composition of tumour microenvironment largely limit the clinical efficacy of this type of therapy. (muni.cz)
  • Vaccination alone or in combination with anti-PD-1/anti-CTLA4 did not elicit tumor regression nor increase CD8 + T cells in the tumor microenvironment (TME), suggesting the presence of immune-suppressive barriers. (nih.gov)
  • Additionally, characterization of the tumor microenvironment such as interactions with immune cells remain largely unknown. (springer.com)
  • These data suggested that targeting mitosis may be an effective approach for sensitizing cancer cells to their inflammatory microenvironment. (uconn.edu)
  • Non-Hodgkin lymphoma is a cancer that starts in cells called lymphocytes, which are part of the body's immune system. (understandingnano.com)
  • Acquired cancer therapy resistance evolves under selection pressure of immune surveillance and favors mechanisms that promote drug resistance through cell survival and immune evasion. (uib.no)
  • Dysregulation of this process has been linked to human diseases including immune disorders, neurodegenerative muscular diseases and cancer. (tmc.edu)
  • A number of viral-based vectors are used to deliver genes to correct a known mutation that causes a disease or modulate the immune response against cancer cells. (foxchase.org)
  • However, advanced forms of cervical cancer, driven by HPV, are poorly responsive to immune response-enhancing treatments involving therapeutic vaccination against these viral neoantigens. (nih.gov)
  • Over the past decade, cancer immunotherapy has been steering immune responses toward cancer cell eradication. (frontiersin.org)
  • The innate immune response by myeloid cells occurs as a succession of events starting at signaling through cytosolic or surface PRRs, followed by effector responses including the release of cytokines, reactive oxygen species (ROS), reactive nitrogen species (RNS), antibacterial peptides and degranulation ( Figure 1 ). (frontiersin.org)
  • Previous studies have juxtaposed and analyzed immune cell compartments between different CCA categorizations such as short or long-term overall survival (OS) [ 16 ]. (springer.com)
  • Despite many breakthroughs in the cancer immunotherapeutic field, targeting Fas remains neglected, primarily due to fear of retaliation against immune-system T-cells," Tushir-Singh told Fox News Digital. (newsrollup.com)
  • By directly activated this trigger, the researchers were able to kill laboratory cells by setting off their self-destruct mechanism. (medindia.net)
  • Harper said the hope is that by understanding how cells die, researchers can better develop new drug combinations or drug targets for specific cancers. (umassmed.edu)
  • Using three different cell lines-adult human skin keratinocytes, human foreskin fibroblasts, and mouse embryonic fibroblasts-the researchers found that the use of these UV emitting devices for just one 20-minute session led to between 20 and 30 percent cell death, while three consecutive 20-minute exposures caused between 65 and 70 percent of the exposed cells to die. (boingboing.net)
  • The researchers caution that while the results show the harmful effects of the repeated use of these devices on human cells, a long-term epidemiological study would be required before stating conclusively that using these machines leads to an increased risk of skin cancers. (boingboing.net)
  • Investigation of the influenza A virus infection, accompanied by lysis of infected cells, led researchers from the Fox Chase Cancer Center to the discovery of proteins involved in regulation of a specific and immunogenic form of cell death, necroptosis. (foxchase.org)
  • Published in the journal Cancer Discovery online April 24 , researchers found that the levels of several genes associated with mitophagy were increased in 20 leukemia patient samples, compared with normal controls. (nyulangone.org)
  • Speaking about other study results, the researchers say they found not only that MFN2 was overly active in people with drug-resistant disease but also that cancer cells exposed to similar cell-death-inducing compounds demonstrated a doubling in mitophagy rates. (nyulangone.org)
  • Several researchers in the United States jointly conducted a systematic evaluation of 37 prospective studies on sugar and cancer risk published in authoritative journals from 1990 to 2017. (ktfnews.com)
  • Researchers say they've located a "kill switch" that can trigger the death of cancer cells. (newsrollup.com)
  • Tushir-Singh pointed out, however, that cancer researchers can now go back and collect human tumor samples from clinical trials and perform new analyses in light of these findings. (newsrollup.com)
  • Yet, ferroptosis also occurs in non-transformed tissues as demonstrated by this study, thus implicating this cell death pathway in the development of a wide range of pathological conditions. (sciencedaily.com)
  • We were able to use this signal chain for pharmacological intervention and consequently to protect cells and tissues. (sciencedaily.com)
  • Before radiation is delivered there is a planning process called a "simulation" where the cancer and normal tissues are mapped. (medlineplus.gov)
  • The histiocytoses encompass a group of diverse disorders characterized by the accumulation and infiltration of variable numbers of monocytes, macrophages, and dendritic cells in the affected tissues. (medscape.com)
  • Dendritic cells display a large amount of MHC-peptide complexes at their surface and can increase the expression of costimulatory receptors and migrate to the lymph nodes, spleen, and other lymphoid tissues, where they activate specific T cells. (medscape.com)
  • AXL kinase inhibition by the small molecule inhibitor bemcentinib or siRNA mediated AXL gene silencing was reported to inhibit the autophagic flux in vitro, bemcentinib treatment blocked clonogenicity and induced immunogenic cell death in drug-resistant NSCLC in vitro, and abrogated the transcription of autophagy-associated genes in vivo. (uib.no)
  • Our results indicate that AXL signaling supports a drug-resistant persister cell phenotype through a novel autophagy-dependent mechanism and reveals a unique immunogenic effect of AXL inhibition on drug-resistant NSCLC cells. (uib.no)
  • Cancers induced by human papillomaviruses (HPV) should be responsive to immunotherapy by virtue of expressing the immunogenic oncoproteins E6/E7. (nih.gov)
  • Unlike conventional chemotherapeutics, SCNPs cause immunogenic cell death or ICD. (cdc.gov)
  • Due to the advent of cancer immunotherapy and other targeted therapies, cancer rates overall in the past decades have decreased significantly," he said. (newsrollup.com)
  • Overall, this review showed that "curcumin can kill a wide variety of tumor cell types through diverse mechanisms. (nutritionfacts.org)
  • Focusing on the mechanisms underlying cancer cell death is key for producing effective multifunctional materials for oncological applications. (europa.eu)
  • Granqvist, V 2022, ' Mechanisms of TRAIL- and Smac mimetic-induced cell death and phenotypical changes in breast cancer ', Doktor, Institutionen för laboratoriemedicin, Lund. (lu.se)
  • PRR on myeloid cells can be triggered by pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs), but also indirectly by secondary mechanisms such as complement activation and circulating antibodies (Abs), resulting in cytolytic and phagocytic effector mechanisms. (frontiersin.org)
  • Pathogen clearance is mediated by mechanisms such as phagocytosis, respiratory burst with the production of ROS and RNS and release of bacteriostatic peptides, but also through the cell-extrinsic initiation of inflammation via the release of proinflammatory cytokines and chemokines ( 24 ). (frontiersin.org)
  • Lacking of both prognostic biomarkers and therapeutic targets, triple-negative breast cancer (TNBC) underscores pivotal needs to uncover novel biomarkers and viable therapies. (nature.com)
  • How exactly cells die is very important because the predominant type of cell death can have multiple impacts on the therapeutic response as cell death itself acts as a second messenger. (muni.cz)
  • In this review, we discuss the different types of programmed cell death (PCD), their connection with HNSCC pathogenesis and possible therapeutic windows that result from specific sensitivity to some form of PCD in some clinically relevant subgroups of HNSCC. (muni.cz)
  • We have used patient-derived, typically resistant, glioma stem-like cells (GSCs) in combination with the previously validated preclinical Inovitro™ TTFields system together with a number of therapeutic DDRi. (nature.com)
  • Consequently, the approach formed on viral-based targeted gene delivery of DAI, RIPK3 and MLKL, can accomplish the therapeutic response and reduce the volume of tumor or virally-infected cells. (foxchase.org)
  • Likewise, targeting and promoting the clearance of IAV infected cells from the host by inducing cell death can be a new therapeutic cure for influenza. (foxchase.org)
  • Breast cancer is a major public health problem worldwide in women and current therapeutic strategies are not adequately effective for this deadly disease. (oncotarget.com)
  • Up until now, this form of cell death has only been thought to be a possible therapeutic approach to treat tumor cells. (sciencedaily.com)
  • Despite improved outcome of surgical approaches and developed therapeutic modalities, CCA recurrence rates remain high with CSCs as the proposed main driver behind cancer relapse [ 10 ]. (springer.com)
  • NaCl nanoparticle s as a cancer therapeutic. (cdc.gov)
  • Despite important advances in early detection and research development, breast cancer remains a major health problem affecting women. (nature.com)
  • He studied mathematics at the University of Vermont, then worked at the Dana-Farber Cancer Institute as a bioinformatician studying breast cancer. (umassmed.edu)
  • For instance, breast cancer can metastasize to the brain, and metastatic cancer cells need to adapt to the new environment there. (medicalxpress.com)
  • The role of the mTOR pathway in estrogen response was evaluated in aromatase-expressing MCF7/Aro breast cancer cells by immunoblotting. (aacrjournals.org)
  • These studies will be applied to cell-based and whole-animal models of recalcitrant tumor types, namely triple negative breast cancer, non-small cell lung cancer and serous ovarian cancer. (elsevierpure.com)
  • We have previously shown the anti-proliferative activity of bitter melon extract (BME) in breast cancer cells. (oncotarget.com)
  • Additionally, we observed that BME treatment in breast cancer cells increases phospho-AMPK expression and inhibits the mTOR/Akt signaling pathway. (oncotarget.com)
  • Subsequently, we demonstrated that BME feeding effectively inhibited breast cancer growth in syngeneic and xenograft mouse models. (oncotarget.com)
  • Breast cancer is the predominant cancer among women in the world-wide and the leading cause of cancer-related mortality [ 1 ]. (oncotarget.com)
  • The American Cancer Society estimates approximately 300,000 women were diagnosed with breast cancer and among them ~30,000 died from this deadly disease in 2016 (American Cancer Society: Breast cancer facts and figures 2015-2016). (oncotarget.com)
  • She quoted what I read in the Breast Cancer Treatment Handbook by Kneece . (cookandcraftwithlove.com)
  • When I had my yearly mammograms, the last one 11 months before the diagnosis, I had breast cancer? (cookandcraftwithlove.com)
  • I'm a wife, mother, retired teacher and breast cancer survivor. (cookandcraftwithlove.com)
  • A Swedish epidemiological cohort study of more than 60,000 women discovered that those consuming diets with high dietary glycemic index, high glycemic load and high carbohydrate intake were more likely to develop breast cancer. (ktfnews.com)
  • Is the Subject Area "Breast cancer" applicable to this article? (plos.org)
  • Whole breast radiation therapy uses high-powered x-rays to kill breast cancer cells. (medlineplus.gov)
  • Methylation-based markers of aging and lifestyle-related factors and risk of breast cancer: a pooled analysis of four prospective studies. (who.int)
  • In this investigation, the cytotoxicity of 23 α-methylene-γ-lactones towards normal breast epithelial MCF-10A cells as well as breast cancer JIMT-1 cells is compared. (lu.se)
  • BRD7 takes part into SWI/SNF and PRC2 chromatin remodelling complexes, whose pleiotropic roles in tumorigenesis make them appealing targets for cancer therapy. (units.it)
  • Non-cancerous cells often die after detaching from the extracellular matrix , but SGK1 activity promotes survival and therefore increases the chances that the cancer could spread, or metastasize. (medicalxpress.com)
  • SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells, Cell Reports (2021). (medicalxpress.com)
  • Autophagy is an evolutionarily conserved process that functions to maintain homeostasis and provides energy during nutrient deprivation and environmental stresses for the survival of cells by delivering cytoplasmic contents to the lysosomes for recycling and energy generation. (tmc.edu)
  • Autophagy is a double edged sword in that it has both pro-survival and pro-death roles in cancer cells. (tmc.edu)
  • High-grade gliomas are primary brain cancers with unacceptably low and persistent survival rates of 10-16 months for WHO grade 4 gliomas over the last 40 years, despite surgical resection and DNA-damaging chemo-radiotherapy. (nature.com)
  • Macroautophagy is a catabolic process that can mediate cell death or survival. (biomedcentral.com)
  • The effect of autophagy inhibition using pharmacologic (3-methyladenine and chloroquine) and genetic [(short hairpin (sh)-mediated knock-down of ATG7 and LAMP2) and small interfering (si)RNA-mediated BECN1 knock-down] approaches on TR-induced cell death was assessed by clonogenic survival, sub-G1 DNA content, and annexinV/PI staining by flow cytometry. (biomedcentral.com)
  • Autophagy is a self degradation process that can mediate cell death as well as survival [ 1 ]. (biomedcentral.com)
  • Therefore, development of specific therapies targeted at CSCs holds hope for improvement of survival and quality of life of cancer patients, especially for patients with metastatic disease. (wikipedia.org)
  • Nick's work has revealed an unexpected way in which an important class of anticancer drugs kill cancer cells," Dr. Lee said. (umassmed.edu)
  • The anticancer effects of curcumin mainly result from the multitude of ways it regulates "programmed cell death. (nutritionfacts.org)
  • SN-CHM is considered potent anticancer activity against SW620, and HT-29 cell lines. (bvsalud.org)
  • In addition, we found that upon oncogene activation BRD7 restrains, independently of p53, the acquisition of malignant phenotypes, such as migration/invasion and stem cell traits. (units.it)
  • As CSCs form a small proportion of the tumor, this may not necessarily select for drugs that act specifically on the stem cells. (wikipedia.org)
  • Cancer stem cells were first identified by John Dick in acute myeloid leukemia in the late 1990s. (wikipedia.org)
  • This functional heterogeneity among cancer cells has led to the creation of multiple propagation models to account for heterogeneity and differences in tumor-regenerative capacity: the cancer stem cell (CSC) and stochastic model. (wikipedia.org)
  • Here, we employ a fluorescent reporter system to track and isolate stem-like cancer cells of cholangiocarcinoma cell lines. (springer.com)
  • Cancer stem cells (CSCs) represent a small subset of the tumor population and reside at the apex of the hierarchy [ 9 ]. (springer.com)
  • Targeted antibodies that prevent leukaemia stem cells from multiplying while attracting the natural killer cells of the body, which in turn send a death signal to the diseased stem cell. (lu.se)
  • However, the AML stem cells, which are located in the bone marrow and are responsible for producing cancer cells, are hard to affect. (lu.se)
  • The killer cells are drawn to the antibody because it has indicated that something is wrong inside the body and, in turn, the killer cells send out a death signal to the AML stem cell. (lu.se)
  • Normal histiocytes originate from pluripotent stem cells, which can be found in bone marrow. (medscape.com)
  • Committed stem cells can mature to become antigen-processing cells, with some possessing phagocytic capabilities. (medscape.com)
  • Pluripotent stem cells can also be committed to produce dendritic cells. (medscape.com)
  • Nicholas Harper, a PhD candidate in the Morningside Graduate School of Biomedical Sciences at UMass Chan Medical School, has received a prestigious Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship from the National Cancer Institute to study cell death as it relates to cancer therapies. (umassmed.edu)
  • Existing cancer treatments have mostly been developed based on animal models, where therapies able to promote tumor shrinkage were deemed effective. (wikipedia.org)
  • If you can kill those cells that are potentially metastatic, then potentially you can get to a point where you can block cancer dissemination," Schafer said. (medicalxpress.com)
  • Thus, the design and evaluation of potent, metabolically stable, novel anti-cancer drugs selected to circumvent senescence will have high impact for the treatment of recalcitrant cancers in the first- line and metastatic setting. (elsevierpure.com)
  • Can a vitamin transform natural killer cells into a cancer therapy? (medicalxpress.com)
  • Our studies highlight the potential role of phenothiazines as agents for combinational therapy with other chemotherapeutic agents in the treatment of different cancers. (tmc.edu)
  • Thus, the administration of RNA virus vectors containing these genes can either be part of cancer therapy, or the treatment of a viral influenzainfection. (foxchase.org)
  • Because radiation is most harmful to quickly growing cells, radiation therapy damages cancer cells more than it damages the slower growing normal cells. (medlineplus.gov)
  • Adding radiation therapy can kill the remaining cancer cells and lower the risk of the cancer growing back. (medlineplus.gov)
  • Radiation therapy, like any cancer therapy, can also damage or kill healthy cells. (medlineplus.gov)
  • Lessons learned from the discovery and development of the sesquiterpene lactones in cancer therapy and prevention. (who.int)
  • In the case of Huntington's Disease (HD), p53 mediates cytotoxicity in HD cells and animal models, whereas its inhibition prevents this phenotype. (units.it)
  • Costimulatory interaction (i.e., second signal) is between CD80(B7.1)/CD86(B7.2) on the dendritic cell, and CD28 on the T cells. (medscape.com)
  • The activated BAX proteins congregated inside the cell's power plants, the mitochondria and caused cell death. (medindia.net)
  • Now, new research using human samples and mouse models has found that resistance of leukemia cells to a widely prescribed drug called venetoclax occurs because of a rapid increase in the breakdown and turnover of mitochondria, structures inside the cell that help power its functions. (nyulangone.org)
  • In addition to their role in producing energy, mitochondria also tell cells to die under certain adverse conditions. (nyulangone.org)
  • Damaged mitochondria can also undergo mitophagy-a form of "self-eating" that prevents them from sending death signals to their cells. (nyulangone.org)
  • The new study and previous research by the team showing misshapen mitochondria in drug-resistant leukemic cells confirmed that increased mitophagy was the source of the problem. (nyulangone.org)
  • AXL-expressing EGFRi-resistant cells revealed phenotypic and cell signaling heterogeneity incompatible with a simple bypass signaling mechanism, and were characterized by an increased autophagic flux. (uib.no)
  • Our high-throughput screen utilized image based fluorescent microscopy for single cell analysis to identify chemical perturbants of the autophagic process. (tmc.edu)
  • Phenothiazines emerged as the largest family of drugs that alter the autophagic process by increasing LC3-II punctae levels in different cancer cell lines. (tmc.edu)
  • TR-resistant cells exhibited high autophagic flux, with more efficient clearance of p62-aggregates in four TR-resistant PCa cell lines: C4-2, LNCaP, DU145, and CWRv22.1. (biomedcentral.com)
  • In contrast, autophagic flux was low in TR-sensitive PC3 cells, leading to accumulation of p62-aggregates. (biomedcentral.com)
  • Inhibition of autophagic flux using chloroquine prevented clearance of p62 aggregates, leading to caspase-8 activation and cell death in C4-2 cells. (biomedcentral.com)
  • Pharmacologic and genetic inhibition of autophagy in PCa cell lines indicate that autophagic flux can determine the cellular response to TR by regulating caspase-8 activation. (biomedcentral.com)
  • Thus, combining various autophagic inhibitors may have a differential impact on TR-induced cell death. (biomedcentral.com)
  • Our data highlighted a link between HPV-induced cancers, systemic amplification of myeloid cells, and the detrimental effects of myeloid cells on CD8 + T-cell activation and recruitment into the TME. (nih.gov)
  • Molecular heterogeneity of head and neck squamous cell carcinomas (HNSCC) causing unpredictability of the clinical response represents a grave challenge for oncologists and seems to be a critical component of treatment response. (muni.cz)
  • Due to its ubiquity, tumor secretion of AGR2 must serve an important role in cancer, yet its molecular function is largely unknown. (nih.gov)
  • This work details the identification and structure-activity relationship studies of a new class of small molecule compounds and explores their anti-mitotic activity and provides a paradigm for exploiting molecular alterations in mutated cells. (uconn.edu)
  • The total chromosomal content of a cell involves approximately 105 genes in a specialized macromolecule of deoxyribonucleic acid (DNA). (cdc.gov)
  • Epidemiologic evidence indicates that lower circulating vitamin D levels are associated with a higher risk of ovarian cancer and that vitamin D supplementation is associated with decreased cancer mortality. (mdpi.com)
  • This project brings together a diverse team of experts committed to evolving the rational design and synthesis of novel microtubule targeting drugs to alleviate the suffering and mortality of cancer patients. (elsevierpure.com)
  • Furthermore, consuming too much sugar also increases cancer mortality. (ktfnews.com)
  • The spice turmeric appears to be able to switch back on the self-destruct mechanism within cancer cells. (nutritionfacts.org)
  • Well, one of the ways curry kills cancer cells is by reprogramming the self-destruct mechanism back into cancer cells. (nutritionfacts.org)
  • In order for a cell to become cancerous it must undergo a significant number of alterations to its DNA sequence. (wikipedia.org)
  • Interestingly, the apoptotic activity of AK301 was more apparent in APC mutant cells, suggesting that AK301 exacerbated the mitotic defects associated with an APC mutation. (uconn.edu)
  • CArOGlu)](CF 3 SO 3 ) ( 1a , tpy = 2,2′:6′,2′′-terpyridine, Glu = glucose) is able to self-assemble into about 100 nm nanoparticles in physiological medium, be taken up by lung cancer cells via energy-dependent endocytosis, and eventually transform into other superstructures distributed in endosomal/lysosomal and mitochondrial compartments apparently following cleavage of the glycosidic linkage. (rsc.org)
  • The malignancy most commonly associated with this disorder is small-cell lung cancer, followed by gynecologic (uterine and cervical) and breast cancers. (medscape.com)
  • [ 1 , 17 ] MAR appears to be increasing in frequency relative to CAR, perhaps because of a decrease in cases of lung cancer. (medscape.com)
  • Detection of Circulating HPV16 DNA as a Biomarker for Cervical Cancer by a Bead-Based HPV Genotyping Assay. (who.int)
  • Cancer is one of the frequently talked about and most feared disease that falls under the genre of lifestyle diseases that have evolved, rather rapidly, in the past two decades. (medindia.net)
  • We identified a switch that turns BAX on, and we believe this discovery can be used to develop drugs that turn on or turn off cell death in human disease by targeting BAX," Nature quoted Walensky, who is also an assistant professor of pediatrics at Harvard Medical School, as saying. (medindia.net)
  • A new study by C. Shad Thaxton, M.D., and Leo I. Gordon, M.D. shows that synthetic HDL nanoparticles killed B-cell lymphoma, the most common form of the disease, in cultured human cells, and inhibited human B-cell lymphoma tumor growth in mice. (understandingnano.com)
  • At first I was heavily focused on developing nanoparticles that could remove cholesterol from cells, especially those involved in heart disease," Thaxton said. (understandingnano.com)
  • Cancer is not just one type of disease. (ktfnews.com)
  • [ 2 ] For example, the entity now referred to as Langerhans cell histiocytosis (LCH) was initially divided into eosinophilic granuloma, Hand-Schüller-Christian disease, and Abt-Letterer-Siwe disease, depending on the sites and severity. (medscape.com)
  • Most recently, this designation was changed to Langerhans cell histiocytosis based on the suggestion by Nezelof that the Langerhans cell represented the primary cell involved in the pathophysiology of the disease. (medscape.com)
  • In this study, by data mining of the Cancer Genome Atlas database, we screened out 4 differentially-expressed microRNAs (DEmiRNAs) between TNBC and normal samples: miR-135b-5p, miR-9-3p, miR-135b-3p and miR-455-5p. (nature.com)
  • The results of the study strongly suggest that the caffeine derivatives in mate tea have potential as anti-cancer agents and could also be helpful in other diseases associated with inflammation, she said. (sciencedaily.com)
  • The Northwestern study also showed that natural HDL did not kill the cells or inhibit tumor growth. (understandingnano.com)
  • In addition, patient samples analyzed by collaborators at Duke University for the study showed that lymphoma cells in patients had an overproduction of these HDL receptors compared to normal lymphocytes. (understandingnano.com)
  • Such a study could reveal if different agents-which could become therapeutics-could potentially eliminate the cells in question. (medicalxpress.com)
  • However, the results of the study were clear: The chronic use of these nail polish drying machines is damaging to human cells. (boingboing.net)
  • This study examined the effect of cancer-secreted AGR2 on normal cells. (nih.gov)
  • Led by scientists at NYU Langone Health and its Laura and Isaac Perlmutter Cancer Center , the study showed that mitophagy helps leukemia cells evade the killing effects of venetoclax, a drug in a class of medications known as BH3 mimetics. (nyulangone.org)
  • In the present study, the team was able to show that Liproxstatin-1 suppresses ferroptosis both in human kidney cells, Gpx4 deletion-induced acute renal failure and in a pre-clinical model of hepatic ischemia reperfusion injury. (sciencedaily.com)
  • However, due to their elusive character and differences in identification among different types of cancer, it remains a challenge to study such cells. (springer.com)
  • The study shows that NaCl nanoparticle s (SCNPs) but not salts are highly toxic to cancer cells. (cdc.gov)
  • Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort. (who.int)
  • We conducted a systematic review of the literature on the effects of vitamin D on ovarian cancer cell. (mdpi.com)
  • In a new development in cancer treatment, a Mumbai company has brought the Cryoablation technology from Israel to give a precise, cold-blooded death to most kinds of tumours and/or cancers. (daijiworld.com)
  • Cryoablation 'ProSense' is currently installed in four hospitals across India and has given 'highly encouraging' results with thousands of cancer patients for the ease of treatment and better pain management. (daijiworld.com)
  • Letrozole (Femara) is an aromatase inhibitor used for treatment of postmenopausal women with hormone-dependent breast cancers. (aacrjournals.org)
  • Treatment of MCF7/Aro cells with estradiol or androstenedione caused modulation of the mTOR pathway, a phenomenon reversed by letrozole or RAD001. (aacrjournals.org)
  • A better understanding of how drugs that perturb autophagy affect cancer cell signaling is of critical importance toimprove the cancer treatment arsenal. (tmc.edu)
  • Natural products play a critical role in the discovery and the development of numerous drugs for the treatment of various types of deadly diseases including cancer [ 3 , 4 ]. (oncotarget.com)
  • Cholangiocarcinoma is an aggressive type of liver cancer with few effective treatment options. (springer.com)
  • Interestingly, normal cells are much more resistant to the treatment due to their relatively low sodium levels. (cdc.gov)
  • The standard treatment of AML is to apply cytostatic drugs which damage the genome of growing cells, preventing them from multiplying. (lu.se)
  • Cancer is the leading cause of death worldwide, and there is a constant need for new treatment strategies. (lu.se)
  • Those antitumorigenic effects include decreased cell migration, cell viability, and ATP production along with abortive autophagy. (tmc.edu)
  • [ 11 ] Immature dendritic cells respond to GM-CSF (not to macrophage colony-stimulating factor [M-CSF]) and become committed to generating dendritic cells, which are "professional" antigen-presenting cells (APCs). (medscape.com)
  • He knew that patients with advanced forms of B-cell lymphoma sometimes have dropping levels of cholesterol. (understandingnano.com)
  • Cancer and neurodegeneration are linked by a relation of inverse comorbidity, cancer patients being at lower risk for neurodegenerative disorders and vice versa. (units.it)
  • The prognosis for patients with avian flu is poor due to ineffective antiviral medication, frequent complications, and high death rate. (foxchase.org)
  • If the activity of DAI and/or RIPK3 contributes to the virulence of the virus, inhibiting DAI or RIPK3- induced cell death may benefit patients infected with a pandemic or virulent strain of the influenza virus. (foxchase.org)
  • Further experiments using mice into which bone marrow from patients with acute myeloid leukemia was transplanted showed that the drug chloroquine, a known mitophagy inhibitor, restored the ability of venetoclax to kill the cancer cells. (nyulangone.org)
  • de Mejia said they were able to identify the mechanism that led to cell death. (sciencedaily.com)
  • That's when the scientists began delving into the mechanism by which the HDL nanoparticles were sticking to the HDL receptors on the lymphoma cell and manipulating cholesterol transport. (understandingnano.com)
  • This phenomenon occurs in as many as 80 percent of cancers. (ktfnews.com)
  • Moreover, the organs or sites where cancer occurs are often places where the metabolism of the organisms is relatively vigorous. (ktfnews.com)
  • Such a description excludes diseases in which infiltration of these cells occurs in response to a primary pathology. (medscape.com)
  • A potential target for developing new cancer drugs has been identified by scientists at Dana-Farber Cancer Institute. (medindia.net)
  • Inspired by the Warburg effect, scientists have further developed a new way to diagnose cancer- positron emission tomography (PET). (ktfnews.com)
  • In the presence of tumor-secreted AGR2, the stromal cells were found to undergo programmed cell death (PCD) characterized by formation of cellular blebs, cell shrinkage, and DNA fragmentation as seen when the stromal cells were UV irradiated or treated by a pro-apoptotic drug. (nih.gov)
  • Caspases are so-called executioner enzymes, that when activated, destroy the cancer cell from within, by chopping up proteins left and right-kind of "death by a thousand cuts. (nutritionfacts.org)
  • These nutrients include glucose, which allows the cell to survive after it detaches from the scaffold of proteins it had been attached to, called the extracellular matrix. (medicalxpress.com)
  • Sugar can produce carbohydrates, proteins, and fats, which to cells are like bricks, cement, and insulating materials with which to build homes. (ktfnews.com)
  • Cells depend on their DNA for coding information to make various classes of proteins that include enzymes, certain hormones, transport proteins, and structural proteins that support life. (cdc.gov)
  • Specialized cell structures called ribosomes are the cellular organelles that actually synthesize the proteins (RNA transcription). (cdc.gov)
  • Understanding this new pathway will unquestionably help us improve the specificity of existing drugs and will likely reveal new ways to target cancer cells for destruction. (umassmed.edu)
  • If we can reduce the activity of NF-kappa-B, the important marker that links inflammation and cancer, we'll be better able to control the transformation of normal cells to cancer cells," she added. (sciencedaily.com)
  • In normal cells, glucose participates in cellular energy production through glycolysis as well as through its complete catabolism via the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). (hindawi.com)
  • In contrast to normal cells, most cancer cells predominantly produce energy by a high rate of glycolysis followed by lactate fermentation, even in the presence of oxygen, a less efficient metabolism compared to a low rate of glycolysis followed by mitochondrial oxidation of pyruvate [ 2 ]. (hindawi.com)
  • Typically, rapidly proliferating tumor cells have glycolytic rates up to 200 times higher than those of their normal tissue of origin, even in the presence of oxygen [ 3 ]. (hindawi.com)
  • In normal cells, the fate of pyruvate depends on many factors, one of which is oxygen availability. (hindawi.com)
  • The goal is to find how to cause cancer cells to die without causing normal cells in a patient to die," Harper said. (umassmed.edu)
  • So you can kill cancer cells really well, but it also affects other normal cells in the patient. (umassmed.edu)
  • But, it tends to leave normal cells alone, for reasons that are not fully understood. (nutritionfacts.org)
  • Furthermore, its ability to kill tumor cells and not normal cells makes curcumin an attractive candidate"-for, supper? (nutritionfacts.org)
  • Thaxton and Gordon are encouraged by their early data showing that the HDL nanoparticles do not appear toxic to other human cells normally targeted by HDLs, normal human lymphocytes or to mice. (understandingnano.com)
  • Cancer-secreted AGR2 induces programmed cell death in normal cells. (nih.gov)
  • Normal cells depend on oxygen for their growth. (ktfnews.com)
  • The metabolism and growth rate of cancer cells are much faster than normal cells, and their consumption of sugar is also faster than we can imagine. (ktfnews.com)
  • The cell would then go back to normal. (cdc.gov)
  • Cancer cells multiply faster than normal cells in the body. (medlineplus.gov)
  • Radiation can disrupt the structure of the DNA (and other macromolecules), thereby disrupting normal cell and organ functions. (cdc.gov)
  • In cancer cells, curcumin, the pigment in the spice turmeric that makes curry powder yellow, upregulates and activates death receptors-as has been demonstrated in human kidney cancer cells, as well as skin cancer, and nose and throat cancer. (nutritionfacts.org)
  • CD95 receptors - also referred to as Fas - have gained the nickname "death receptors" because they send a signal that causes cancer cells to "self-destruct," according to a press release from UC Davis. (newsrollup.com)