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  • membrane
  • TBRII is localized in cell membrane in normal liver ( c , arrows), but ectopically accumulated in cytoplasm in HCC ( d , HCC Sample 6, arrow), Smad4 expression is decreased in HCC ( f , HCC Sample 2, arrows) compared with normal liver ( e , arrows). (nih.gov)
  • vitro
  • To explore the biological mechanisms underlying Angelica sindsis polysaccharide (ASP) -induced aging of human-derived leukemia stem cells (LSCs) in vitro. (nih.gov)
  • ASP may induce the senescence of LSCs effectively in vitro, P16-Rb cell signaling pathway play a significant role in this process. (nih.gov)
  • This work demonstrates the effects of magnolol, a compound found in the roots and bark of the magnolia tree Magnolia officinalis, on the behavior of LNCaP, DU145 and PC3 human prostate cancer cells in vitro. (islandscholar.ca)
  • The results obtained throughout this thesis suggest that magnolol can affect the behavior of human prostate cancer cells in vitro, suggesting that magnolol may have potential as a novel anti-prostate cancer agent. (islandscholar.ca)
  • apoptotic
  • We determined the effects of wogonin on the changes of cell cycling and apoptotic responses of cells. (hindawi.com)
  • Mesenchymal Stems cells (MSC, control) and two BC cell lines were treated with six well established pro-apoptotic phytochemicals individually and in combination (super cocktail), at bioavailable levels. (jcancer.org)
  • The influence of regulatory noncoding RNA molecules on apoptotic cell signaling has not been extensively explored, but increasing evidence points to a role for microRNAs (miRNA) in the control of intrinsic developmental and proliferative cell programs and ligand-induced cell signaling ( 19 - 21 ). (aacrjournals.org)
  • siRNA
  • To down-regulate Sp1 activity, we treated the cells for 48 h with 0.025 or 0.05 nM mithramycin, a known inhibitor of Sp1, or we transfected the cells with Sp1 siRNA, then maintained them for 72 h. (aacrjournals.org)
  • CCND3
  • Translocations targeting CCND2, CCND3 , and MYCN do occur in t(11;14)-negative mantle cell lymphomas. (thefreedictionary.com)
  • Here, we describe a suite of ddPCR assays for detecting and quantifying clinically relevant EZH2, STAT6, MYD88, and CCND3 mutations in B-cell lymphomas. (thefreedictionary.com)
  • Cell-cycle alterations were common, including homozygous deletion of CDKN2A in 4 (20%) and amplifications of CCND3 , CCNE1, CCND1, CCND2, and CDK4 in 8 (40%) of the MPBC cases, a subset of which may indicate the potential for use of cell-cycle inhibitors. (thefreedictionary.com)
  • miR (show MLXIP Antibodies )-212 exerts growth-suppressive effects in Adult T-cell leukemia/lymphoma (ATL) cells largely by targeting CCND3 and may have therapeutic potential in ATL. (antibodies-online.com)
  • Antibodies
  • Search, Find and Buy Antibodies, ELISA Kits and Proteins. (antibodies-online.com)
  • Cells were stained with 50 μg/mL propidium iodide (PI, Sigma, St Louis, MO) and analyzed by FACscan flow cytometry (Becton Dickinson) for cell cycle status, stained with PE- or FITC-conjugated anti-CD34, anti-CD71, or anti-GPA antibodies and analyzed for cell surface antigens. (bloodjournal.org)
  • Anti-Cyclin Antibodies are ideal for investigators involved in Cell Signaling, cell biology and Signal Transduction research. (rockland-inc.com)
  • molecular
  • In this study, we investigated the molecular and biological effects of wogonin in human ovarian A2780 cancer cells. (hindawi.com)
  • Improved clinical treatment will therefore ultimately require a more thorough understanding of the molecular mechanisms that regulate the invasion of glioma cells from primary tumor sites as well as the identification and specific targeting of the critical drivers of glioma invasion. (biomedcentral.com)
  • complex
  • The RCC1-Ran complex with other proteins is part of a signal transmission pathway that detects unreplicated DNA. (thefreedictionary.com)
  • This constitutes a suitable cell model to follow the sequence of events preceding neuronal death when there is formation of the p25-Cdk5 complex. (biologists.org)
  • By several different criteria, calcineurin is dispensable for B cell tolerance, indicating that this phosphatase complex modulates immunogenic, but not tolerogenic, responses in vivo. (antibodies-online.com)
  • Biological
  • Biological mechanisms of human-derived leukemia stem cells senescence regulated by Angelica sinensis polysaccharide]. (nih.gov)
  • p>This section provides any useful information about the protein, mostly biological knowledge. (uniprot.org)
  • receptors
  • This phenomenon resulted from the greater ability of isoflurane to induce calcium release from the endoplasmic reticulum via inositol-1,4,5-trisphosphate receptors in cell cultures. (asahq.org)
  • glioma cells
  • Typical for high-grade glioma is that glioma cells infiltrate extensively into surrounding pivotal brain structures, thereby rendering current treatments largely ineffective. (aacrjournals.org)
  • Radiation therapy shows too many neurotoxic side effects to enlarge the high-dose target volume to include these glioma cells. (aacrjournals.org)
  • exposure
  • Effects of combined radiofrequency radiation exposure on the cell cycle and its regulatory proteins. (emf-portal.org)
  • Exposure to wogonin also resulted in downregulated protein levels of estrogen receptor alpha (ER- α ), VEGF, Bcl-2, and Akt and increased expressions of Bax and p53. (hindawi.com)
  • Indeed, exposure to exogenous estrogen was found to promote the viability of ER-positive ovarian cancer cell lines [ 11 , 12 ]. (hindawi.com)