• MTT analysis, PI/Annexin V staining, transwell and metabolic flux assays were performed to examine the effects of C1QBP on proliferation, apoptosis, migration, invasion, and oxidative phosphorylation of HCC cells. (jcancer.org)
  • Moreover, the oxidative phosphorylation was moderately decreased when C1QBP was depleted. (jcancer.org)
  • Dr. Otto Warburg first described, more than 80 years ago, that a fundamental biochemical difference between tumor cells and their normal counterparts was that tumor cells rely on aerobic glycolysis for ATP generation, unlike most normal differentiated cells of the body, which use mitochondrial oxidative phosphorylation. (aacrjournals.org)
  • regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. (proteopedia.org)
  • Compound 51 inhibited the proliferation of 13 out of 15 cancer cell lines with IC50 values between 0.27 and 6.9 muM, which correlated with the complete suppression of retinoblastoma phosphorylation and the onset of apoptosis. (proteopedia.org)
  • Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. (proteopedia.org)
  • In normal cells, glucose participates in cellular energy production through glycolysis as well as through its complete catabolism via the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). (hindawi.com)
  • GSEA analysis found STARD12 and STARD14 were associated with glycolysis, oxidative phosphorylation and tumor related signaling pathways. (medsci.org)
  • To achieve the above target, cancer cells preferentially use aerobic glycolysis, otherwise known as the Warburg effect, over oxidative phosphorylation. (kdwis.com)
  • Some of the impairments in glycolytic pathway, Krebs cycle and oxidative phosphorylation that contribute to cancer cell growth, development, progression, survival and malignancy would be critically discussed. (kdwis.com)
  • The pathogenesis of Reye syndrome, while not precisely elucidated, appears to involve mitochondrial injury resulting in dysfunction that disrupts oxidative phosphorylation and fatty-acid beta-oxidation in a virus-infected, sensitized host potentially with an underlying occult inborn error of fatty acid oxidation, urea cycle or mitochondrial disorder. (medscape.com)
  • Reishi suppresses the proliferation of ovarian cell cells. (greenmedinfo.com)
  • Suppression of proliferation and oxidative stress by extracts of Ganoderma lucidum in the ovarian cancer cell line OVCAR-3. (greenmedinfo.com)
  • Cancer cells demand high energy production to sustain their pathological increase in proliferation rate. (hindawi.com)
  • Loss-of-function assays showed that proliferation, migration and invasion of HCC cells were mitigated while cell apoptosis was augmented upon the loos of C1QBP. (jcancer.org)
  • In the present study, we assessed the possible effects of frankincense, pine needle and geranium essential oils on cell viability, proliferation, migration and invasion as well as the possible mechanisms. (spandidos-publications.com)
  • In the present study, we clearly revealed that frankincense, pine needle and geranium essential oils suppressed cell viability, proliferation, migration and invasion in human BC MCF-7 cells. (spandidos-publications.com)
  • Moreover, we elucidated the regulatory AMPK/mTOR pathway involving essential oils in BC cell proliferation, invasion and apoptosis development. (spandidos-publications.com)
  • In each category, studies related to growth control genes, cell proliferation, apoptosis, DNA repair genes, antioxidant and drug detoxification genes, genes of drug metabolizing enzymes, tissue remodeling genes and genes of antibody-dependent cellular cytotoxicity were discussed separately. (researchsquare.com)
  • Studies from a number of laboratories in the past decade have revealed that the central pathways deregulated in cancer often serve to coordinately regulate both classic oncogenic signaling pathways controlling cell proliferation and cell survival with pathways controlling cell metabolism. (aacrjournals.org)
  • Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). (proteopedia.org)
  • Cell proliferation involves the replication of all cellular contents with the required energy for this to happen. (hindawi.com)
  • To prevent aberrant cell proliferation, these pathways are tightly regulated. (hindawi.com)
  • This activation is necessary for both cell proliferation as well as glucose uptake and use. (hindawi.com)
  • Many laboratories have focused on the functions of the clock genes and proteins that are involved in cellular activities, including cell survival, cell cycle regulation, proliferation, apoptosis, DNA damage repair, and tumor promotion or suppression [ 5 , 6 ]. (explorationpub.com)
  • We found that cisplatin inhibited cell proliferation by a cytotoxicity, characterized by DNA damage and modulation of oxidative stress. (oncotarget.com)
  • The proliferation and growth of PDAC cells were detected by Celigo analysis, MTT, and clone formation assay. (jcancer.org)
  • PYCR1 interference was able to inhibit cell proliferation and promote cell apoptosis of pancreatic cancer. (jcancer.org)
  • 2009). Evidence of similarities in the redox control of cell proliferation in animals and plants are provided, particularly glutathione recruitment into the nucleus early in the cell proliferation, which appears to be important in the control of progression through the cell cycle in both kingdoms. (cam.ac.uk)
  • During these processes, the cancer cells acquire multiple allelic mutations in genes such as proto-oncogenes, tumour suppressor (TS) genes and other genes that control cell proliferation ( Hahn and Weinberg, 2002 ). (kdwis.com)
  • Through these channels, ROS can participate in a wide range of intracellular physiological and pathological processes, including cell proliferation, cell-cycle progression, antiapoptosis, invasion, metastasis, and angiogenesis, which contribute to malignant transformation and cancer progression. (elsevierpure.com)
  • Doxorubicin (DOX) is known as an anticancer drug that acts in the G2/M phase of the cell cycle to arrest cell proliferation and induce cellular senescence (see the upper left figure). (dojindo.com)
  • It was discovered when pulmonary fibroblasts slowed down their proliferation and eventually ended in cell death after cell passaging had been performed for more than 8 months. (dojindo.com)
  • Alterations in redox cell signalling produce changes that, synergistically with DNA alterations, induce deregulation of cell cycle control and cell proliferation ( 1 ). (iiarjournals.org)
  • Relationships between ROS, uncontrolled cell proliferation, activation of NF-κB and overexpression of p53 point to the significance of oxidative stress in cancer development. (iiarjournals.org)
  • In response to mito- pendence between the key mecha- gens, cell proliferation is triggered by nistic characteristics. (who.int)
  • H - Ras cell proliferation are also linked with haematopoietic cel s. (who.int)
  • This enzyme contributes to repair of oxidative DNA damage by supporting several strand break repair pathways and nucleotide or base excision repair pathways, as well as acting as a co-activator of transcription factors such as NRF2 and HIF1a, which control expression of antioxidant enzymes involved in removal of electrophiles and secondary metabolites. (aston.ac.uk)
  • Reactive oxygen species (ROS), generated as consequence of oxidative metabolism, activate signal transduction pathways, which contribute to cellular homeostasis [ 1 ]. (hindawi.com)
  • Lipids, amino acids, and nucleotides necessary for the biosynthesis of the daughter cells are mostly provided by intermediate metabolites of these pathways. (hindawi.com)
  • Melatonin can disrupt estrogen-mediated cellular pathways, ensuing in a lattice drop of estrogenic stimulus to the breast cancer cells. (explorationpub.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • promoting abnormal regulation of signalling pathways involved in cell cycle regulation, genetic stability, apoptosis and cell differentiation. (kdwis.com)
  • These marker proteins are known to be tumor suppressors and regulate the cell cycle mainly through two pathways (p16Ink4a-RB and p53-p21CIP1). (dojindo.com)
  • High mobility group B (HMGB) proteins have been previously related to the onset and progressions of cancers of different origins. (hindawi.com)
  • This review describes recent advances in the role of human HMGB proteins and other proteins interacting with them, in cancerous processes related to oxidative stress, with special reference to ovarian and prostate cancer. (hindawi.com)
  • Changes in the redox state of cells affect proteins, lipids, and nucleic acids in different ways. (hindawi.com)
  • Invadopodia are cancer cell protrusions rich in structural proteins (e.g. (biorxiv.org)
  • Cancer cells are known to proliferate uncontrollably and therefore, have greater demand for energy and a ready supply of the building blocks necessary for the biosynthesis of macromolecules such as nucleotides, proteins and lipids). (kdwis.com)
  • Elevated intracellular levels of reactive oxygen species (ROS), derived from increased ROS production or impaired antioxidant defenses, cause oxidative damage to various cellular components including DNA, proteins, and lipids, as well as activation of intracellular proto-oncogenic signaling. (elsevierpure.com)
  • [ 10 ] CSB gene defects ( ERCC6 ) (at least 78 different mutations) result in altered expression of antiangiogenic and cell cycle genes and proteins, particularly p21, which can result in inhibition of cell cycle progression and growth. (medscape.com)
  • The results showed that Ganoderma lucidum inhibits cell growth and disruption of cell cycle progression via down regulation of cyclin D1. (greenmedinfo.com)
  • Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. (lsbio.com)
  • LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. (lsbio.com)
  • In our recent study we found that circadian clock genes play a role in regulation of the hair growth cycle during synchronized hair follicle cycling, uncovering an unexpected connection between these two timing systems within skin. (aging-us.com)
  • Melatonin has oncostatic properties that are mediated by induction of apoptosis, arresting the cell cycle, regulation of metabolic activity, and the inhibition of hypoxia-inducible factor 1α (HIF-1α) activity [ 9 ]. (explorationpub.com)
  • We hypothesized that cisplatin induces cytotoxicity through DNA adduct formation, oxidative stress, transcriptional factors (p53 and AP-1), cell cycle regulation, stress signaling and apoptosis in APL cells. (oncotarget.com)
  • Cisplatin also activated p53 and phosphorylated activator protein (AP-1) component, c-Jun at serine (63, 73) residue simultaneously leading to cell cycle arrest through stimulation of p21 and down regulation of cyclins and cyclin dependent kinases in APL cell lines. (oncotarget.com)
  • Cellular redox homeostasis is considered to play an important role in the regulation of the plant cell cycle but there is little information on the precise functions of key redox metabolites such as ascorbate, glutathione and pyridine nucleotides in this process. (cam.ac.uk)
  • Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. (affbiotech.cn)
  • The protein HMGB1 behaves as a redox sensor and its structural changes, which are conditioned by the oxidative environment, are associated with different functions of the protein. (hindawi.com)
  • HMGB1 is an abundant protein, 10 6 molecules per cell [ 7 ], which has been postulated as a redox sensor [ 8 ]. (hindawi.com)
  • Immunohistochemistry in diagnostic surgical pathology: contributions of protein life-cycle, use of evidence-based methods and data normalization on interpretation of immunohistochemical stains. (lsbio.com)
  • Hou G, Lu Z, Wang Z, Yang X. The Mitochondrial Protein C1QBP Promotes Hepatocellular Carcinoma Progression by Enhancing Cell Survival, Migration and Invasion. (jcancer.org)
  • Although a variety of studies have shown that Complement C11 binding protein (C1QBP) may play a tumor-promoting or tumor-suppressive role in cancer, the functions and mechanisms of C1QBP in HCC progression are under-investigating. (jcancer.org)
  • Complement C11 binding protein (C1QBP, also named p32 and HABP1) is a multifunctional protein which plays a pivotal role in diverse cellular processes such autophagy and cell apoptosis [ 7 , 8 ]. (jcancer.org)
  • Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases that act as key regulatory elements in cell cycle progression. (proteopedia.org)
  • Inhibition of DNA-dependent protein kinase catalytic subunit by small molecule inhibitor NU7026 sensitizes human leukemic K562 cells to benzene metabolite-induced apoptosis. (cdc.gov)
  • We have previously reported that exposure of workers to benzene and to benzene metabolite hydroquinone in cultured cells induced DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to mediate the cellular response to DNA double strand break (DSB) caused by DNA-damaging metabolites. (cdc.gov)
  • Treatment with NU7026 did not alter the production of reactive oxygen species and oxidative stress by hydroquinone but repressed the protein level of DNA-PKcs and blocked the induction of the kinase mRNA and protein expression by hydroquinone. (cdc.gov)
  • It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. (thermofisher.com)
  • The role of CHOP in the programmed cell death of ER-stressed cells is correlated with its role promoting protein synthesis and oxidative stress inside the ER (4). (affbiotech.com)
  • Acquisition of a point mutation in the propeller urgently monitored in the field because this pattern is not detected by current assays and represents a major threat to region of the K13 protein after 30 drug pressure cycles antimalarial drug policy. (cdc.gov)
  • DeMarini, and Chapter 20, by Rice and cell death determine the size protein in several signal ing path- and Herceg). (who.int)
  • Interestingly, a large fraction of the genome, more than six thousand genes, exhibits changes in expression that correlates with the progression of the hair growth cycle, thus underscoring the complexity of this process [ 4 , 5 ]. (aging-us.com)
  • One of the surprises that came from this study was the finding that genes regulated by the core circadian clock mechanism showed expression changes that correlated with the hair growth cycle, with highest expression during the telogen-anagen transition. (aging-us.com)
  • While these genes show a clear circadian pattern of expression in skin, as was previously demonstrated [ 9 - 11 ], their amplitude was higher during telogen and early anagen (Figure 1 ), indicating that in skin, the expression of clock controlled genes is dependent both on circadian mechanism and the hair growth cycle. (aging-us.com)
  • Although drugs, for example a MEK inhibitor Refametinib [ 5 ], targeting key driver genes involved in HCC progression are being utilized for the clinical intervene, chemotherapy-resistance and the following cancer recurrence or metastasis still hinder the improvement of patient survival rates. (jcancer.org)
  • STARD12 co-expressed genes participated in cell cycle and DNA replication, and STARD14 were enriched in ECM-receptor interaction. (medsci.org)
  • MST3 is present in human placenta, where it plays an essential role in the oxidative stress-induced apoptosis of trophoblasts in normal spontaneous delivery. (umbc.edu)
  • Further, AMP-17 treatment resulted in an increase in reactive oxygen species (ROS) levels, depolarization of the mitochondrial membrane potential (MMP), and changes in the cell cycle, leading to the apoptosis and necrosis, which ultimately contributed to the death of C. albicans cells. (researchsquare.com)
  • As a result, changes in SA-ß-Gal expression, cell cycle progression, and mitochondrial membrane potential were observed. (dojindo.com)
  • These are as follows: sustained proliferative signalling, cell death resistance, replicative immortality, genome instability and increased mutations, tumour-promoted inflammation, insensibility to growth repressors, deregulation of cellular energetics, evasion of immune destruction, induction of metastasis, and promotion of angiogenesis. (hindawi.com)
  • Irreversible cell cycle arrest is one of the phenomena that characterize cellular senescence. (dojindo.com)
  • Cellular senescence is controlled by various factors such as cell type and physiological conditions, such as oxidative stress. (dojindo.com)
  • Common detection indicators for assessing cellular senescence include features related to cell cycle progression (DNA synthesis, p16/p21 expression, etc.), features related to morphology (of the cell, nucleus, nucleolus, etc. (dojindo.com)
  • Subsequent studies have revealed that cellular senescence is caused not only by telomere length reduction, but also by external factors such as oncogene activation, oxidative stress, and DNA damage. (dojindo.com)
  • Research into apoptosis, necrosis, autophagy, and cellular senescence is very important for understanding the intracellular functions that control cell survival and death. (dojindo.com)
  • Recently, various fields have given particular attention to cellular senescence due to the recent discoveries of SASP (a known cancer-causing factor) and senescence-related phenomena in stem cell research. (dojindo.com)
  • CHOP expression is induced by certain cellular stresses including starvation and the induced CHOP suppresses cell cycle progression from G1 to S phase (2). (affbiotech.com)
  • Under 1064 nm irradiation, photothermal therapy (PTT) not only induces tumor cell death but also accelerates lactate exhaustion. (bvsalud.org)
  • Consistent with the in vitro activities, frankincense essential oil was effective in inhibiting tumor growth and inducing tumor cell apoptosis in a human BC mouse model. (spandidos-publications.com)
  • Tumor cell invasion and metastasis require cancer cells to be both proliferative and invasive, i.e. migrate through the tissue and assemble invadopodia. (biorxiv.org)
  • In this review we deal in the molecular mechanisms, the epigenetic effects and modulation of the oxidative stress pathway of ketogenic diets, that underlie its possible role, in the treatment of infantile gliomas, as a complementary approach to conventional cancer therapy. (frontiersin.org)
  • Commonly used radio- and chemotherapies are prooxidant strategies that alter cancer cells through ROS modulation and induce cell death [ 5 , 6 ]. (hindawi.com)
  • Metastasis is a complex, multi-step process that is initiated when cancer cells in the primary tumor acquire invasive properties, including motility and the ability to breakdown the extracellular matrix (ECM) 1 , and is responsible for the majority of cancer-related mortalities 2 . (biorxiv.org)
  • Its ability to directly scavenge free radicals and to act as a cosubstrate in the GSH peroxidase catalyzed reduction of H 2 O 2 and lipid hydroperoxides makes GSH central to defence mechanisms against intra- and extracellular oxidative stress 9 . (ersjournals.com)
  • RF Radiation (900 MHz)-Induced DNA Damage and Cell Cycle Arrest in Testicular Germ Cells in Swiss Albino Mice," Toxicology and Industrial Health, posted online October 13, 2016. (microwavenews.com)
  • 2016). In a subsequent study, we found that AMP-17 can impair cell wall integrity, destroy cell membrane structure, and increase cell membrane permeability in C. albicans (Ma et al. (researchsquare.com)
  • This acetyl group is further metabolised in the tricarboxylic acid (TCA) cycle and fully oxidized to yield CO 2 . (kdwis.com)
  • induces growth arrest or apoptosis depending on the physiological circumstances and cell type. (lsbio.com)
  • Advanced head and neck squamous cell carcinoma (HNSCC) is treated with radiotherapy, chemotherapy, targeted therapy or a combination of these treatments. (researchsquare.com)
  • The aim of the study was to investigate the relationship between plasma levels of malondialdehyde (MDA), a routinely used marker of oxidative stress, and squamous cell carcinoma of the oral cavity and oropharynx (OSCC). (iiarjournals.org)
  • SCC: squamous cell carcinoma. (iiarjournals.org)
  • Squamous cell carcinoma (SCC) of the oral cavity and oropharynx (OSCC), the fifth most common cancer worldwide ( 4 ), represents a considerable health problem. (iiarjournals.org)
  • The ternary strategy is one of the effective methods to regulate the morphology of the active layer in organic solar cells (OSCs). (bvsalud.org)
  • MST3 phosphorylates the STK NDR and may play a role in cell cycle progression and cell morphology. (umbc.edu)
  • Embryo morphology al ows options, the discovery of cell-free DNA in the evaluation of its growth, viability, and biological fluids has led to major advances in implantation capacity. (who.int)
  • It may also regulate paxillin and consequently, cell migration. (umbc.edu)
  • Taken together, the findings reveal a central role of DNA-PKcs in hydroquinone-induced hematotoxicity in which it coordinates DNA DSB repair, cell cycle progression, and apoptosis to regulate the response to hydroquinone-induced DNA damage. (cdc.gov)
  • Compared with traditional antibiotics, AMPs have a broader spectrum of antimicrobial effects, better thermal stability, and less toxicity toward human cells. (researchsquare.com)
  • Overall, this study highlights the molecular mechanisms that underline cisplatin toxicity to APL cells, and provides insights into selection of novel targets and/or design of therapeutic agents to treat APL. (oncotarget.com)
  • Induced oxidative stress causes DNA damage in germ cells, which alters cell cycle progression leading to low sperm count in mice. (microwavenews.com)
  • Oxidative stress produces DNA damage and also induces responses, which could help the cell to restore the initial equilibrium. (hindawi.com)
  • The maintenance of the steady-state equilibrium between ROS generation and elimination is crucial for cell survival, while its loss causes cell death by different mechanisms triggered by oxidative damage. (hindawi.com)
  • Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. (lsbio.com)
  • Oxidative damage of membrane phospholipids is called lipid peroxidation with malondialdehyde (MDA), an end-product of lipid peroxidation, being a widely used marker of cell exposure to oxidative stress ( 2 - 6 ). (iiarjournals.org)
  • Research on this topic may be of great procedures were approved by the Eth- Results interest since oxidative damage has ics Review Committee of the National been proposed as a pathogenic mecha- Research Centre. (who.int)
  • Although electrophiles are considered as detrimental to cells, accumulating recent evidence indicates that proliferating non-cancerous and particularly cancerous cells utilize these agents for pro-survival and cell cycle promoting signaling. (aston.ac.uk)
  • C1QBP is correlated with a poor prognosis of HCC patients and promotes the survival, migration and invasion of HCC cells. (jcancer.org)
  • In the near future, novel chemo-/gene-therapies might be applied to treat cancer patient converting cancerous cells into normal differentiated cells. (intechopen.com)
  • Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. (affbiotech.com)
  • Multidrug tolerance results from drug-induced parasites (ring-stage parasites) to arrest their cell cycle and quiescence, which enables parasites to survive exposure enter a quiescence state ( 9,10 ). (cdc.gov)
  • In contrast to normal cells, most cancer cells predominantly produce energy by a high rate of glycolysis followed by lactate fermentation, even in the presence of oxygen, a less efficient metabolism compared to a low rate of glycolysis followed by mitochondrial oxidation of pyruvate [ 2 ]. (hindawi.com)
  • In contrast, cancer cells shift their metabolism toward lactate production even in the presence of oxygen [ 4 ], partly through genetic modifications that stabilize the transcription factor Hypoxia Inducible Factor (HIF) involved in the adaptation of the cells to hypoxia, under nonhypoxic conditions as well as generating an adaptive response to the hypoxic microenvironment (Figure 1 ). (hindawi.com)
  • It will elucidate on the additional hallmarks of cancer mentioned above, i.e. reprogramming energy metabolism in cancer cell by pointing out to key experiments pertaining, and that serve as proof, to this phenomenon. (kdwis.com)
  • In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. (hindawi.com)
  • Cancer development and progression in humans involves multi-step processes that usually take place over many decades. (kdwis.com)
  • In order to systematically discover transcriptional activity associated with the hair growth cycle, we profiled mRNA expression at a genome-wide level over multiple time points corresponding to morphogenesis and two synchronized hair growth cycles. (aging-us.com)
  • For example, follicular B-cell lymphomas display a characteristic chromosomal translocation in which the bcl-2 gene is brought under the transcriptional control of the immunoglobulin light-chain gene promoter, thereby causing overexpression of bcl-2. (medicoapps.org)
  • Consequently, the recruitment of immune cells during chronic inflammation increases oxidative stress (OS) in the microenvironment [ 2 ]. (hindawi.com)
  • More importantly, CQG NPs-induced pyroptosis and cuproptosis can jointly promote immunosuppressive tumor microenvironment (TME) remodeling, enhance the infiltration of immune cells into the tumor, and subsequently activate robust systemic immunity. (bvsalud.org)
  • This study proposes and validates a strategy for enhancing immunotherapy through photothermal-assisted depletion of lactate sustained by cycle-like O2 supply, with blocking the tryptophan (Trp)/Kyn metabolic pathway. (bvsalud.org)
  • The tripeptide glutathione (l-y-glutamyl-l-cysteinyl-glycine, GSH) plays a pivotal role in metabolic and cell-cycle related functions in virtually all cells. (ersjournals.com)
  • Metabolic adaptations of cancer cells. (hindawi.com)
  • This indolamine advances apoptosis, which arrests the cell cycle and regulates metabolic activity. (explorationpub.com)
  • Metabolic reprogramming plays an important role in tumor progression and antitumor immunity. (medsci.org)
  • Recent high-impact research has shown the genomic/genetic differences between cancer and normal cells using methods such as next-generation sequencing [ 1 , 2 ]. (intechopen.com)
  • However, cancer cells overcome these controls, in particular by acquiring genetic mutations leading to the activation of oncogenes (pten, myc) or loss of tumor suppressors (p53) [ 1 ]. (hindawi.com)
  • Cancer, on the other hand, can be defined as a heterogeneous group of genetic diseases characterised by unregulated clonal expansion of somatic cells brought about by multiple genetic and epigenetic changes ( Evan and Vousden, 2001 ). (kdwis.com)
  • Progression as the final stage of carcinogenesis involves irreversible changes from the benign to the malignant cell phenotype by the continuous accumulation of genetic alterations with oxidative stress probably playing a similar role as in the previous stages ( 9 ). (iiarjournals.org)
  • The environmental light-dark cycle is the potent regulator of melatonin synthesis. (explorationpub.com)
  • Laboratory studies have shown that Ganoderma lucidum enhances immune functions and also inhibits growth of various cancer cells both in vitro and in vivo. (greenmedinfo.com)
  • One advantage of this cleverly designed material is that it can disrupt the specific antioxidant defense mechanism of tumor cells by inhibiting the nuclear factor-erythroid 2-related factor 2 (NRF2)-quinone oxidoreductase 1 (NQO1) signaling pathway. (bvsalud.org)
  • In conclusion, the present study indicated that frankincense, pine needle and geranium essential oils were involved in the progression of BC cells possibly through the AMPK/mTOR pathway. (spandidos-publications.com)
  • The Invadopodia state is characterized by cell stasis and the presence of invadopodia, whereas the Migration state is defined by cell translocation and the absence of invadopodia. (biorxiv.org)
  • Typically, rapidly proliferating tumor cells have glycolytic rates up to 200 times higher than those of their normal tissue of origin, even in the presence of oxygen [ 3 ]. (hindawi.com)
  • Increased oxidant burden and antioxidant, e.g. glutathione (GSH), deficiency in the lower respiratory tract have been thought to play a role in the progression of IPF. (ersjournals.com)
  • Thus, unveiling the mechanisms for HCC progression is of great significance for the identification of potential therapeutic targets or agents, which might be further developed for adjuvant therapeutic strategies. (jcancer.org)
  • Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells. (lsbio.com)
  • Inhibition of DNA-PKcs by NU7026 markedly potentiated the apoptotic and growth inhibitory effects of hydroquinone in proerythroid leukemic K562 cells in a dose-dependent manner. (cdc.gov)
  • It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. (affbiotech.cn)
  • Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. (proteopedia.org)
  • Carcinogenesis is a complex multi-stage process, when the cell phenotype undergoes changes from healthy through precancerous to malignant. (iiarjournals.org)
  • Our results caution that this coordination between invasion and cell cycle must be considered when designing effective chemotherapies. (biorxiv.org)
  • Glioblastomas are intrinsic brain tumors believed to originate from neuroglial stem or progenitor cells. (frontiersin.org)
  • In this seminar, I will show how the intracellular redox state was modulated during the growth cycle and discuss the interplay between the major redox pyridine nucleotides, glutathione and ascorbate pools (Pellny et al. (cam.ac.uk)
  • 2009) Pyridine nucleotide cycling and control of intracellular redox state in relation to poly (ADP-ribose) polymerase activity and nuclear localisation of glutathione during exponential growth of Arabidopsis cells in culture. (cam.ac.uk)
  • Scientists have discovered that, in the absence of resident stem cells, senescent cells can instruct neighboring somatic cells to reprogram. (dojindo.com)
  • Cell cycle progression is faster in cells in which invadopodia are abolished (by Tks5 knockdown), evidenced by earlier induction of cyclins A and B. A close look at the regulators of G1 revealed that the overexpression of p27 kip1 , but not p21 cip1 , causes faster turnover of invadopodia and increased ECM degradation. (biorxiv.org)
  • However, excessive levels of ROS are cytotoxic and lead to the induction of programmed cell death ( 11 ). (iiarjournals.org)