• Cell cycle transitions are generally triggered by variation in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. (elifesciences.org)
  • Malaria-causing parasites have a life cycle with unique cell-division cycles, and a repertoire of divergent CDKs and cyclins of poorly understood function and interdependency. (elifesciences.org)
  • Central components of these networks are the cyclin-dependent kinases (CDKs). (elifesciences.org)
  • Of these, five are divergent CDK-related kinases (CRK), i.e. they are clearly related to CDKs but have no clear orthologues in the yeast or human kinomes. (elifesciences.org)
  • Further studies on its effect on cyclins and cyclin-dependent kinases (CDKs) [not measured in our study] may shed light on new treatment options for COVID-19. (biomedcentral.com)
  • CDKs belong to a large family of STKs that are regulated by their cognate cyclins. (umbc.edu)
  • In mechanistic studies, silibinin (50-75 microM) modulated the protein levels of cyclin-dependent kinases (CDKs) (4, 6, and 2), cyclins (D1, D3, and E), CDKIs (p18/INK4C, p21/Cip1, and p27/Kip1) in a differential manner in these three cell lines. (nih.gov)
  • Structural principles in cell-cycle control: beyond the CDKs. (embl-heidelberg.de)
  • The pursuit of drugs that inhibit cyclin-dependent kinases (CDKs) has been an intense area of research for more than 15 years. (sdstate.edu)
  • In mammalian cells, cell cycle is controlled by the sequential activation of cyclin dependent kinases (CDKs). (sdstate.edu)
  • Four CDKs (CDKs 1, 2, 4 and 6) and their activating cyclins (A, B, D and E), play key roles in cell cycle progression. (sdstate.edu)
  • While, expression and activity of cyclins and CDKs are tightly regulated in normal cells, they are often deregulated in cancer cells through frequent overexpression and frequent inactivation. (sdstate.edu)
  • To address this, numerous biochemical, molecular biological studies were carried out in multiple cancer cell lines along with molecular docking studies to determine the interactions between aspirin/salicylic acid with CDKs and cyclins. (sdstate.edu)
  • The studies carried out during the course of this dissertation work have established that aspirin, salicylic acid and salicylic acid metabolites and derivatives target all more 4 members of CDK family namely CDKs 1, 2, 4 and 6, the major findings of which are detailed below. (sdstate.edu)
  • Our studies demonstrate that both aspirin and its primary metabolite, salicylic acid, decreased cyclin A2, B1, D3, CDKs 1, 2, 4 and 6 protein levels in a diverse panel of cancer cell lines. (sdstate.edu)
  • These brakes are regulated by a group of enzymes known as cyclin-dependent kinases (CDKs). (mycancergenome.org)
  • The cyclin-dependent kinase (CDK) inhibitors p21 and p16 inhibit the activity of CDKs, such as CDK4. (medscape.com)
  • Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases that act as key regulatory elements in cell cycle progression. (proteopedia.org)
  • The profiling of compound 51 against a panel of 339 kinases revealed high selectivity for CDKs, with preference for CDK2 and CDK5 over CDK9, CDK1, CDK4, and CDK6. (proteopedia.org)
  • Cell cycle de-regulation in cancer cells have been associated with overexpression/activity of cyclins, cyclin-dependent kinases (CDKs), cell division cycle 25 (Cdc25) phosphatases and/or decreased expression/mutations of cyclin-dependent kinase inhibitors (CDKIs) (6). (cancerdir.com)
  • also called CCNB1) cyclin B, a cell cycle inducible protein, prominent in mitosis, which activates cdks. (nih.gov)
  • also called CCNA1) cyclin A, a cell cycle inducible protein, prominent in S-phase, which activates cdks. (nih.gov)
  • Model Structure * * We propose an integrated computational model for the network * of cyclin-dependent kinases (Cdks) that controls the dynamics * of the mammalian cell cycle. (nih.gov)
  • The cyclin D2/CDK4 or CDK6 complexes have key roles in controlling the progression of cell cycle from the Gap 1 (G1) phase to the synthesis (S) phase. (nih.gov)
  • Serine/Threonine Kinases (STKs), Cyclin-dependent protein kinase 4 (CDK4) and CDK6-like subfamily, catalytic (c) domain. (umbc.edu)
  • The CDK4/6-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. (umbc.edu)
  • CDK4 and CDK6 partner with D-type cyclins to regulate the early G1 phase of the cell cycle. (umbc.edu)
  • CDK4 and CDK6 are both expressed ubiquitously, associate with all three D cyclins (D1, D2 and D3), and phosphorylate the retinoblastoma (pRb) protein. (umbc.edu)
  • AR activation controls G1-S phase progression through fostering enhanced translation of the D-type cyclins, which promote cell cycle progression through activation of CDK4/6. (nih.gov)
  • However, the D-type cyclins harbor additional, CDK4/6 kinase-independent, functions through manipulation of transcription factors, including AR. (nih.gov)
  • Consistent with these observations, silibinin caused a reduction in kinase activity of CDK4 and 2 in all cell lines except no effect on CDK4 kinase activity in H460 cells, and concomitantly reduced Rb phosphorylation. (nih.gov)
  • This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. (nih.gov)
  • It has been established that CDK4,6/cyclin D and CDK2/cyclin E/A promote the passage through G1 and S phases, whereas CDK1/cyclin B regulates the transition through the late G2 and mitosis. (sdstate.edu)
  • The purpose of this study is to: - Test how well the study medicine Abemaciclib, a CDK4/6 inhibitor, works to shrink lung cancer tumors in the body. (mycancergenome.org)
  • Abemaciclib ( CDK4 /6 inhibitors) is an investigational drug that works by interrupting the rapid and uncontrolled growth of cancer cells. (mycancergenome.org)
  • Alterations causing over-activity of two of these enzymes, CDK4 andCDK6, are found in a variety of cancers, including small cell lung cancer with retinoblastoma ( Rb ) protein. (mycancergenome.org)
  • Although one molecule of p21 is sufficient to inhibit cyclin/Cdk complexes ( 22 ), Cip/Kip CKIs have been detected in active cyclin D/Cdk4 complexes ( 24 - 27 ). (aacrjournals.org)
  • p21 was shown to stabilize interactions between Cdk4 and cyclin D and promote the formation of active complexes in a concentration-dependent manner ( 27 ). (aacrjournals.org)
  • The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
  • The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)
  • In estrogen receptor-positive breast cancer cell lines, cyclin D1 and CDK4/6 promote phosphorylation of the retinoblastoma protein (Rb), cell cycle progression, and cell proliferation. (lillymedical.com)
  • Furthermore, HDGF could interact with c-Jun, an oncogenic transcription factor, which eventually induced the expressions of cell cycle promoters, CCND1/CDK4/CDK6. (omicsdi.org)
  • This finding suggested that NAP1L1 could interact with HDGF, and the latter recruited c-Jun, a key oncogenic transcription factor, that further induced CCND1/CDK4/CDK6 expression, thereby promoting proliferation and chemoresistance in glioma cells. (omicsdi.org)
  • Cell Cycle Protein Expression in Neuroendocrine Tumors: Association of CDK4/CDK6, CCND1, and Phosphorylated Retinoblastoma Protein With Proliferative Index. (omicsdi.org)
  • Palbociclib is an oral, highly selective inhibitor of CDK4/6 kinase activity that prevents cellular DNA synthesis by prohibiting progression of the cell cycle from the G1 to S phase by blocking retinoblastoma (Rb) phosphorylation. (bigagainstbreastcancer.org)
  • They show that the CDK4/6 inhibitor palbociclib did not improve invasive disease-free survival (iDFS) when given in addition to standard endocrine therapy for a period of one year to patients with hormone receptor-positive (HR+), HER2-negative primary breast who are at high risk of recurrence following neoadjuvant chemotherapy. (bigagainstbreastcancer.org)
  • The method was applied to the A549 lung cancer cell line, and we identified specific kinases known to have an important role in this type of cancer (TGFBR2, EGFR, PHKG1 and CDK4). (biomedcentral.com)
  • These oscillations correspond * to the repetitive, transient activation of cyclin D/Cdk4-6 in * G(1), cyclin E/Cdk2 at the G(1)/S transition, cyclin A/Cdk2 * in S and at the S/G(2) transition, and cyclin B/Cdk1 at the * G(2)/M transition. (nih.gov)
  • Interstitial Lung Disease (ILD)/Pneumonitis: Patients treated with CDK 4/6 inhibitors should be monitored for pulmonary symptoms indicative of ILD/pneumonitis. (nih.gov)
  • Cyclin-dependent kinase 4/6 inhibitors, which act by inhibiting progression from the G1 to S phases of the cell cycle, include palbociclib, ribociclib, abemaciclib, and trilaciclib. (nih.gov)
  • They are also regulated by the INK4 family of inhibitors which associate with either the CDK alone or the CDK/cyclin complex. (umbc.edu)
  • From NCBI Gene: The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. (nih.gov)
  • In addition, specific proteins classified as CDK inhibitors capable of binding to cyclin/CDK complexes to inhibit their enzyme activity also play a significant role in regulating cell cycle. (sdstate.edu)
  • Single treatment of both mTOR inhibitors induced a significant G 1 cell cycle arrest and combination treatment with Dasatinib reduced the expression of cell cycle regulator cyclin D1 or increased the expression of cell cycle inhibitor p21. (medsci.org)
  • Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)
  • 12,18,19] The development of specific tyrosine kinase inhibitors that target elements in these pathways has allowed molecularly driven clinical investigation in MCL. (cancernetwork.com)
  • Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases. (proteopedia.org)
  • Many kinase inhibitors have been approved as cancer therapies. (biomedcentral.com)
  • Recently, libraries of kinase inhibitors have been extensively profiled, thus providing a map of the strength of action of each compound on a large number of its targets. (biomedcentral.com)
  • We have developed the Kinase Inhibitors Elastic Net (KIEN) method, which integrates information contained in drug-kinase networks with in vitro screening. (biomedcentral.com)
  • The method will facilitate the design of new kinase inhibitors and the development of therapeutic interventions with combinations of many inhibitors. (biomedcentral.com)
  • [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
  • miR-137 has also been shown to directly inhibits CDK6 (Cyclin-dependent kinase 6) expression and decreases the level of phosphorylated RB (retinoblastoma), a known CDK6 downstream target. (wikipedia.org)
  • 7. miR-148a-3p suppresses the progression of acute myeloid leukemia via targeting cyclin-dependent kinase 6 (CDK6). (nih.gov)
  • Further, p53 protein is responsible not only for the expression of miRNAs but also acts as a target molecule for miRNAs and plays a crucial function in the AA-UTUC pathogenicity through activation of cyclin-dependent kinase (CyclinD1) and cyclin protein kinase 6(CDK6) to support cell cycle arrest. (edu.mk)
  • CDK6 plays an important role in cell differentiation. (umbc.edu)
  • Abemaciclib is an inhibitor of cyclin-dependent kinase (CDK) 4 and CDK6. (lillymedical.com)
  • p27 inhibits CDK6/CCND1 complex formation resulting in cell cycle arrest and inhibition of cell proliferation. (omicsdi.org)
  • In this study, Genevestigator, Kaplan-Meier Plotter, and the Human Protein Atlas databases were used to analyze the expression of p27, cell division protein kinase 6 (CDK6), and cyclin D1 (CCND1), as well as its prognostic value in different tumor tissues and corresponding normal tissues. (omicsdi.org)
  • The effects of p27, CDK6, and CCND1 on the proliferation of lung cancer cells were examined by the MTT assay, and flow cytometry was used to investigate the mechanism by which p27 affected cell proliferation. (omicsdi.org)
  • The results showed that p27, CDK6, and CCND1 played different roles in tumorigenesis and development, which are in accordance with CDK6 and CCND1 in affecting the cell cycle and cell proliferation. (omicsdi.org)
  • p27 regulated the cell cycle and inhibited cell proliferation by affecting formation of the cell cycle-dependent complex CDK6/CCND1, but did not directly affect the expression of CDK6 and CCND1. (omicsdi.org)
  • Moreover, CCND1 did not regulate the cell cycle alone, but rather, functioned together with CDK6. (omicsdi.org)
  • CDX-1140 is a novel agonist CD40 antibody, which can lead to apoptosis and impaired growth of cancer cells due to direct signaling effects. (medscape.com)
  • 1. Simvastatin regulates the proliferation, apoptosis, migration and invasion of human acute myeloid leukemia cells via miR-19a-3p/HIF-1α axis. (nih.gov)
  • 2. Dexmedetomidine Regulates Proliferation, Apoptosis, Migration, and Invasion in Ovarian Cancer Cells via MiR-155-HIF-1α Axis. (nih.gov)
  • 4. [Proliferation, migration and apoptosis of acute myeloid leukemia cells regulated by mir-23a-3p targeting SMC1A and the mechanism]. (nih.gov)
  • 6. Long non-coding RNA UCA1 modulates cell proliferation and apoptosis by regulating miR-296-3p/Myc axis in acute myeloid leukemia. (nih.gov)
  • 12. MiR-25-3p targets PTEN to regulate the migration, invasion, and apoptosis of esophageal cancer cells via the PI3K/AKT pathway. (nih.gov)
  • 16. Long noncoding RNA NEAT1 modulates cell proliferation and apoptosis by regulating miR-23a-3p/SMC1A in acute myeloid leukemia. (nih.gov)
  • Furthermore, substituting Rapamycin in the modified multimodal RIST protocol with Torin-2 reduced cell viability and induced apoptosis despite a significant lower Torin-2 drug concentration applied. (medsci.org)
  • However, a number of recent studies have pointed out that in addition to being an inhibitor of cell proliferation, p21 acts as an inhibitor of apoptosis in a number of systems, and this may counteract its tumor-suppressive functions as a growth inhibitor. (aacrjournals.org)
  • The TP53 gene is also capable of stimulating apoptosis of cells containing damaged DNA. (medscape.com)
  • TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)
  • In vitro, continuous exposure to abemaciclib inhibited Rb phosphorylation and blocked progression from G1 into S phase of the cell cycle, resulting in senescence and apoptosis. (lillymedical.com)
  • The model has four outcomes that convey alternative cell fates: proliferation, (transient) cell cycle arrest, apoptosis and senescence. (biomedcentral.com)
  • Among other components, the tumour suppressor p53 protein triggers cellular programs that lead to different fates: transient arrest followed by cell cycle re-entry upon damage repair, permanent cell cycle arrest (senescence) or, if the damage is irreparable, initiation of cell death program (apoptosis). (biomedcentral.com)
  • Changes in cell viability, apoptosis, lactate dehydrogenase release, and cell cycle analysis were measured by cell counting kit-8 assay, annexin V/ propidium iodide staining, and enzyme-linked immunosorbent assay, respectively. (medsci.org)
  • Extracellular Gal-3 is secreted via a non-classical pathway (because of lack of signal peptides) and can bind to the cell surface through glycosylated proteins, thereby triggering or modulating cellular responses such as mediator release or apoptosis. (nature.com)
  • This review will focus on innovative drug development for the treatment of relapsed or refractory MCL, including therapies aimed at disrupting the B-cell receptor signaling pathway, regulators of apoptosis, and immunomodulators. (cancernetwork.com)
  • Secondary genetic events that enhance cell growth, activate cell survival pathways, inhibit apoptosis, and promote interactions with the tumor microenvironment also serve as potential targetable mechanisms of lymphomagenesis. (cancernetwork.com)
  • Spleen tyrosine kinase (SYK) is amplified in some patients with MCL, and its inhibition leads to the arrest of cell proliferation and apoptosis. (cancernetwork.com)
  • The broad cyclin-dependent kinase (CDK) inhibitor flavopiridol leads to downregulation of cyclin D1 and induces apoptosis of malignant lymphocytes in vitro and in murine lymphoma models. (cancernetwork.com)
  • Compound 51 inhibited the proliferation of 13 out of 15 cancer cell lines with IC50 values between 0.27 and 6.9 muM, which correlated with the complete suppression of retinoblastoma phosphorylation and the onset of apoptosis. (proteopedia.org)
  • It was found that vitexicarpin may block the cell cycle in Growth 2 Phase (G2)/Mitosis (M) phase by inhibiting the expression of Cyclin-Dependent Kinase 1 (CDK1), Cellular Myelocytomatosis Oncogene (c-myc) and survivin, thereby inhibiting the proliferation and promoting the apoptosis of human non-small cell lung cancer cell line (H322) [ 3 ]. (ijpsonline.com)
  • Vitexicarpin inhibits the growth of human prostate cancer cell line (PC-3) cells and promotes the apoptosis by blocking the cell cycle of prostate cancer PC-3 cells in G 2 /M phase [ 5 ]. (ijpsonline.com)
  • Furthermore, VPS25 knockdown inhibited the proliferation, blocked the cell cycle, and promoted apoptosis in glioma cells. (biomedcentral.com)
  • In addition to it, taxol also interferes with a number of biochemical pathways and protein to bring about apoptosis and cell death. (ijpsr.com)
  • Beside deregulated cell cycle, cancer cells develop mechanisms to evade apoptosis, and there is a lot of overlapping in the molecular regulation of cell cycle and apoptosis (7). (cancerdir.com)
  • Several studies have reported the buy Lacosamide role of androgen receptor (AR) in regulating the cell cycle as well as apoptosis in PCA cells (8,9). (cancerdir.com)
  • Therefore, the agent/s that could simultaneously target the deregulated cell cycle, apoptosis resistance mechanisms and AR would be effective in inhibiting PCA cells proliferation. (cancerdir.com)
  • Here, we assessed the anti-cancer efficacy of a novel water-soluble phenolic polymer namely p-DGA (poly[3-(3, 4 dihydroxyphenyl) glyceric acid]) (Figure 1A) isolated from the roots of the Caucasian species of comfrey (showed that p-DGA treatment affects cell cycle progression and induces apoptosis in -chronic lymphocyte leukemia cells (14). (cancerdir.com)
  • We also compared p-DGA efficacy with its synthetic monomer and through modulating AR expression as well as regulators of cell cycle and apoptosis. (cancerdir.com)
  • Abnormalities in apoptosis, cell cycle, and proliferation of human bone marrow mesenchymal stem cells (hBMSCs) significantly impact bone metabolism and remodeling, and thereby cause various skeletal disorders. (researchsquare.com)
  • Long-term exposure to a high dosage of dexamethasone (Dex) induces apoptosis and inhibits proliferation of mesenchymal stromal cells (MSCs), which are probably the primary causes of osteoporosis (OP) and steroid-induced osteonecrosis of the femoral head (SONFH). (researchsquare.com)
  • The differentially expressed mRNA and lncRNA were associated with the regulation of cell apoptosis. (researchsquare.com)
  • Meanwhile, several signaling pathways involved in the regulation of cell apoptosis, including mTOR signaling pathway, Ras signaling pathway, HIF-1 signaling pathway, NF-kappa B signaling pathway, and TGF-beta signaling pathway, also were identified in interaction net of the significant pathways (Path-Net) analysis. (researchsquare.com)
  • Besides, validation by qRT-PCR of the key differentially expressed mRNA and lncRNA, reported to be closely related to cell apoptosis, confirmed the reliability of the microarray dataset. (researchsquare.com)
  • For example, whereas short and low dosage of Dex treatment on MSCs stimulated osteogenesis[ 7 , 8 ], long-term exposure to high dosage (10 − 6 mol/L) induced apoptosis and inhibited proliferation of BMSCs[ 5 , 6 ]-probable mechanisms in osteoporosis (OP) and steroid-induced osteonecrosis of the femoral head (SONFH). (researchsquare.com)
  • p27 plays critical roles in cell proliferation, differentiation, and apoptosis, which have been well studied in mammals and Drosophila. (omicsdi.org)
  • The highly correlated results unmistakably point to a systematic downregulation of mitochondrial activities, which we hypothesize aims to downgrade the mitochondria-mediated apoptosis and the dependency of cancer cells on angiogenesis. (biomedcentral.com)
  • It is usually understood that carcinogenesis is a multistep process that involves defects of the genetic pathways including cell proliferation, cell adhesion, cell death and apoptosis [ 2 ]. (biomedcentral.com)
  • Evidence already exists that nutrients may alter prostate cancer risk and tumor cell behavior by influencing hormonal regulation, cell signaling, cell cycle control, apoptosis, differentiation, and carcinogen metabolism. (nih.gov)
  • Olaparib inhibits PARP, an enzyme that helps cells, including tumor cells, repair damaged DNA, while selumetinib is a selective inhibitor of mitogen activated protein kinase kinases 1 and 2 (MEK 1/2). (medscape.com)
  • Palbociclib inhibits the CD4/6 pathways which reduces proliferation of breast tumor cells by preventing progression from the G1 to the S cell cycle phase. (advochealth.com)
  • De Veylder L, Beemster GT, Beeckman T, Inzé D (2001) Cks1at overexpression in Arabidopsis thaliana inhibits growth by reducing meristem size and inhibiting cell-cycle progression. (edu.pl)
  • supported by the observations that MPF kinase inhibitor such as roscovitine inhibits spontaneous resumption of meiosis in porcine as well as rat oocytes cultured in vitro [14,15]. (cgrpreceptor.com)
  • Previous studies suggest that RO-3306 (an ATP competi- tive Cdk1 inhibitor) specifically inhibits Cdk1 activity and thereby cell cycle progression in human cancer cell line [16,23,24]. (cgrpreceptor.com)
  • Recent studies suggest that RO-3306 reversibly inhibits spontaneous resumption from diplotene arrest without affecting their further progression to M-II stage and development to blastocyst stage in porcine oocytes cultured in vitro [25]. (cgrpreceptor.com)
  • It functions as a microtubule-stabilizing compound and inhibits mitosis of cancer cells, thereby providing a protective role in the treatment of cancers. (ijpsr.com)
  • a protein kinase that inhibits Cdk1. (nih.gov)
  • The A and B boxes each contain the cyclin-fold structural motif, with the LxCxE-binding site on the B-box cyclin fold being similar to a Cdk2-binding site of cyclin A and to a TBP-binding site of TFIIB. (embl-heidelberg.de)
  • The decrease in cyclin A2 and cyclin B1 levels as well as CDK1 and CDK2 protein levels were associated with a corresponding decrease in the levels of messenger RNAs, suggesting that both aspirin salicylic acid regulate their expression at both transcriptional and post translational levels. (sdstate.edu)
  • They can bind and inhibit a broad range of cyclin/Cdk complexes, with a preference for those containing Cdk2 ( 17, 18 ). (aacrjournals.org)
  • Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. (proteopedia.org)
  • NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. (proteopedia.org)
  • Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. (proteopedia.org)
  • Zhao J, Kennedy BK, Lawrence BD, Barbie DA, Matera AG, Fletcher JA, Harlow E. NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription. (proteopedia.org)
  • Meanwhile, VPS25 induced a G0/G1 phase arrest of the cell cycle in glioma cells by directly mediating p21, CDK2, and cyclin E expression, and JAK-signal transducer and activator of transcription (STAT) activation. (biomedcentral.com)
  • A29: Cdk2 can bind either Cyclin A or Cyclin E. For details on activation of Cdk2 (PMID: 10436023). (nih.gov)
  • Once the genetic material of SARS-CoV-2 enters the cell through receptor binding and then membrane fusion and penetration into the nucleus for replication, the virus controls the kinase family of enzymes and acts as switches that turn proteins on or off through the process of phosphorylation. (biomedcentral.com)
  • There are 61335 CYCLIN domains in 41443 proteins in SMART's nrdb database. (embl-heidelberg.de)
  • Taxonomic distribution of proteins containing CYCLIN domain. (embl-heidelberg.de)
  • The complete taxonomic breakdown of all proteins with CYCLIN domain is also avaliable . (embl-heidelberg.de)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing CYCLIN domain in the selected taxonomic class. (embl-heidelberg.de)
  • Structures of cyclins, Rb and TFIIB reveal that a common motif occurs in proteins regulating three consecutive events of cell-cycle control. (embl-heidelberg.de)
  • Recent results on the structures of two cyclins, cyclin A and cyclin H, and two transcription factor mediator proteins, TFIIB and the A pocket region of the retinoblastoma tumour suppressor protein (Rb), show that they share domains with a strikingly similar alpha-helical topology, despite remote sequence identity. (embl-heidelberg.de)
  • We hypothesized that aspirin and/or its primary metabolite salicylic acid may target cell cycle regulatory proteins modulating their level as well as functions. (sdstate.edu)
  • Egan EA, Solomon MJ (1998) Cyclin-stimulated binding of CKS proteins to cyclin-dependent kinases. (edu.pl)
  • Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
  • We evaluated expression of key proteins involved in cell cycle regulation in a large cohort of NETs. (omicsdi.org)
  • Cyclin dependent kinases (CDK), a group of serine/threonine kinases, play a key role in regulating cell cycle progression by interacting with specific cyclin proteins in luminal-type tumours. (bigagainstbreastcancer.org)
  • Regulation can occur through modification of the p27 protein's structure, its interaction with other proteins, or its localization within the cell. (medlineplus.gov)
  • The aim of our study was to evaluate survival outcomes in malignant mixed Mullerian tumors (MMMT) of the uterus with respect to the role of cell cycle and apoptotic regulatory proteins in the carcinomatous and sarcomatous components. (biomedcentral.com)
  • Cell survival and apoptotic regulatory proteins such as the Bcl-2 family of genes, PCNA, p16, p21, p27, and cyclin D1 are of vital importance to malignant neoplasms in prolonging cell survival. (biomedcentral.com)
  • The aim of this study is to evaluate the role of cell cycle and apoptotic regulatory proteins in the carcinomatous and sarcomatous components of uterine MMMT in relation to clinico-pathological data including survival outcomes. (biomedcentral.com)
  • For example, epigenetic mechanisms, such as changes in the methylation and/or acetylation pattern of certain DNA regions or of the histone proteins around which the DNA is wrapped, contribute to the reversion of normal liver cells into progenitor and stem cells that can develop into HCC. (nih.gov)
  • Present study was aimed to find out whether RO-3306, specific cyclin dependent kinase 1 (Cdk1) inhibitor could protect against postovulatory aging-mediated spontaneous exit from M-II arrest in rat eggs cultured in vitro. (cgrpreceptor.com)
  • The morphological changes, percentage of spontaneous exit from M-II arrest, total and specific phosphorylation status of Cdk1, cyclin B1 level and Cdk1 activity were analyzed. (cgrpreceptor.com)
  • Postovulatory aging increased Thr14/Tyr15 phosphorylated Cdk1 level, decreased Thr161 phosphorylated Cdk1 as well as cyclin B1 levels and increased Cdk1 activity in aged eggs cultured in vitro. (cgrpreceptor.com)
  • On the other hand, RO-3306 protected postovulatory aging-induced changes in specific phosphorylation of Cdk1, cyclin B1 level, inhibited the kinase activity and prevented spontaneous exit from M-II arrest. (cgrpreceptor.com)
  • Conclusions: Our results suggest that postovulatory aging destabilizes MPF by modulating specific phosphorylation of Cdk1 and cyclin B1 level. (cgrpreceptor.com)
  • It is a heterodimer protein containing cyclin dependent kinase 1 (Cdk1) as a catalytic subunit and cyclin B1 as a regulatory subunit [1,5,6]. (cgrpreceptor.com)
  • MPF stabilization requires association of cyclin B1 with Cdk1 [3,5,7], while dissociation of cyclin B1 from MPF heterodimer and its degradation destabilizes MPF and triggers meiotic resumption from diplotene as well as metaphase-II (M-II) arrest [3-5,7-13]. (cgrpreceptor.com)
  • MPF destabiliza- tion may also be due to series of phosphorylation at Thr14/ Tyr15 and dephosphorylation at Thr161 of Cdk1 thereby modulates meiotic cell cycle progression [3,4,13]. (cgrpreceptor.com)
  • Cdk1 is an important cell cycle regulator, and it is an appropriate target for the study of cell cycle progression [16]. (cgrpreceptor.com)
  • controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. (proteopedia.org)
  • A30: Cdc2 (Cdk1), in association with either Cyclin B or Cyclin A, phosphorylates ORC2. (nih.gov)
  • 17. MiR-548c-3p suppressed the progression of papillary thyroid carcinoma via inhibition of the HIF1α-mediated VEGF signaling pathway. (nih.gov)
  • These three CKIs contain a conserved region of sequence at the NH 2 terminus that is required and sufficient for the inhibition of cyclin/Cdk complexes, whereas the COOH terminal regions are variable in length and function ( 12, 14 - 16 ). (aacrjournals.org)
  • VPS25 regulates endosomal protein sorting by interacting with the CHMP6 subunit in the ESCRT-III complex, and the inhibition of this interaction prevents cell division and leads to cell death [ 12 ]. (biomedcentral.com)
  • It has been recently reported that the inhibition of histone demethylase by GSK-J4 affects cellular viability and cell cycle progression of differentiating cells. (molcells.org)
  • observed that the inhibition of KDM6 by GSK-J4 induced cell death in early differentiating ESCs. (molcells.org)
  • Within the scope of the protodynamic therapy concept, our study suggests a novel mechanism for cis-UCA-induced inhibition of cancer cell survival, based upon compromised signalling and metabolic functions and cell cycle arrest leading to apoptotic and necrotic cell death. (biomedcentral.com)
  • Overexpression of cyclin D2 is associated with the development of tumors. (nih.gov)
  • Conditional overexpression of Gal-3 in mouse HSCs under the transcriptional control of Tie2 or Vav1 promoters (Gal-3 Tg) causes cell cycle retardation via induction of p21. (nature.com)
  • MCL is characterized by overexpression of cyclin D1, a cell cycle regulator that promotes cellular proliferation. (cancernetwork.com)
  • Cyclin D1 overexpression is the distinguishing aberrancy in MCL. (cancernetwork.com)
  • Transwell assays were used to analyze the knockdown effects of hsa_circRNA_101996, miR-143, and overexpression of TET2 on cell proliferation, migration, and invasion abilities. (jcancer.org)
  • The molecular consequence of translocation is overexpression of the protein cyclin D1 (coded by the PRAD1 gene located close to the breakpoint). (medscape.com)
  • The primary regulator of CDK activity is the cyclin subunit. (elifesciences.org)
  • In our previous research, we showed that the cyclin-dependent kinase regulatory subunit (CKS2) in maize (Zea mays L.) was induced by water deficit and cold stress. (edu.pl)
  • Hadwiger J, Wittenberg C, Mendenhall M, Reed S (1989) The saccharomyces cerevisiae cks1 gene, a homolog of the schizo-saccharomyces pombe suc1+ gene, encodes a subunit of the cdc28 protein kinase complex. (edu.pl)
  • Finally, the relationship between m 6 A ( N 6 -methyladenosine) modification and high expression of the ESCRT subunit was studied. (biomedcentral.com)
  • The regulatory subunit of this kinase is Dbf4/Ddk. (nih.gov)
  • abstract = "Introduction: We assessed the Aurora A kinase inhibitor, alisertib, plus paclitaxel (henceforth referred to as alisertib/paclitaxel) as second-line treatment for SCLC. (psu.edu)
  • We show that Plasmodium berghei CDK-related kinase 5 (CRK5), is a critical regulator of atypical mitosis in the gametogony and is required for mosquito transmission. (elifesciences.org)
  • p21 acts as a negative regulator of cell-cycle progression by binding and inhibiting complexes formed between the cyclin-dependent kinases and their catalytic partners the cyclins. (dundee.ac.uk)
  • These results demonstrate that Gal-3 is a negative regulator of cell-cycling in HSCs and plays a crucial role in adult hematopoiesis to prevent HSC exhaustion. (nature.com)
  • These changes can be inherited and are, therefore, found in every cell, but more often, they are somatically acquired and restricted to tumor cells. (medscape.com)
  • Tumor models were established by subcutaneous injection of tumor cells in Bl6/Rag2/GammaC double knockout mice. (jcancer.org)
  • Furthermore, the high refractoriness of liver cancer to treatments has been associated with the interaction of very complex and diverse mechanisms of chemoresistance, which can act synergistically to protect tumor cells from the chemotherapy agents [ 3 ] . (encyclopedia.pub)
  • they are not inherited and are present only in tumor cells. (medlineplus.gov)
  • 10. miR-29b-3p suppresses the malignant biological behaviors of AML cells via inhibiting NF-κB and JAK/STAT signaling pathways by targeting HuR. (nih.gov)
  • These responses are elicited through signalling pathways, which activate cell cycle checkpoints and basically lead to three cellular fates: cycle arrest promoting DNA repair, senescence (permanent arrest) or cell death. (biomedcentral.com)
  • Rather than due to increased kinase activation, the observed effect seemed to be caused by a decrease in both tyrosine and serine/threonine phosphatase activities that act as critical regulators of the ERK and JNK signalling pathways. (biomedcentral.com)
  • We annotated PETs to pathways of KEGG database and compared the murine B16F1 melanoma transcriptome with three non-melanoma murine transcriptomes (Melan-a2 melanocytes, E14 embryonic stem cells, and E17.5 embryo). (biomedcentral.com)
  • Upregulation of cell cycle progression, MAPK, and PI3K/Akt pathways were more limited to certain region(s) of the pathway. (biomedcentral.com)
  • A pathway enrichment analysis of the set of kinases identified by the method showed that axon guidance, activation of Rac, and semaphorin interactions pathways are associated to a selective response to therapeutic intervention in this cell line. (biomedcentral.com)
  • Besides making prediction about the cellular response to drugs, the method identifies critical kinase targets and pathways that are statistically associated to drug sensitivity in a given cell line. (biomedcentral.com)
  • By inhibiting the Cdc42/PAK signalling pathway, miR-137 decreases proliferation, invasion and G0/G1 cell cycle progression of colorectal cancer cells. (wikipedia.org)
  • Previous studies have found that GA-MSCs promote proliferation and maintain the stemness of glioma stem cells (GSCs) through the IL-6/gp130/STAT3 pathway [ 10 ]. (biomedcentral.com)
  • DNA damage increases TP53 levels through an ATM-dependent pathway. (medscape.com)
  • 11-13] More specifically, evidence that MCL pathogenesis is antigen-dependent[14] and that these tumors exhibit constitutive B-cell receptor (BCR) activation[15] posits the BCR signaling pathway as a rational prospect for drug development. (cancernetwork.com)
  • 16,17] In addition, BCR ligation activates the prosurvival phosphoinositide-3 kinase (PI3K) pathway via AKT, which itself has been implicated in MCL pathogenesis. (cancernetwork.com)
  • Current research shows that the role of ESCRT in tumorigenesis is due to the loss of transmembrane protein homeostasis and the resulting consequences on signal transduction, and it could account for a defective MVB pathway and cell cytokinesis. (biomedcentral.com)
  • We applied the robust Gene Identification Signature Paired-End diTag technology (GIS-PET) to reveal the global pathway aberrations in melanoma by using the murine melanoma cell line B16F1 as a model system. (biomedcentral.com)
  • Our study supports that a) cell cycle and apoptotic regulatory protein dysregulation is an important pathway for tumorigenesis and b) p53 is an important immunoprognostic marker in MMMT of the uterus. (biomedcentral.com)
  • Alcohol also acts indirectly on another molecule called toll-like receptor 4 (TLR4) that is a key component in a crucial regulatory pathway in the cells and whose dysregulation is involved in the development of HCC. (nih.gov)
  • Cell senescence is a physiological process of irreversible cell cycle arrest that contributes to various stress conditions, telomere shortening, DNA damage, reactive oxygen species (ROS) production, and mitochondrial dysfunction are main characteristic of cell senescence [ 1 ]. (degruyter.com)
  • Silibinin treatment (10-75 microM) inhibited cell growth and targeted cell-cycle progressing causing a prominent G(1) arrest in dose- and time-dependent manner. (nih.gov)
  • The cyclin-dependent kinase inhibitor p21 is induced by both p53-dependent and -independent mechanisms following stress, and induction of p21 may cause cell cycle arrest. (aacrjournals.org)
  • Activation of p21 or p16 therefore causes cell cycle arrest. (medscape.com)
  • The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)
  • In addition, p19ARF binds to and promotes the degradation of MDM2, the product of the murine double minute 2 gene, and this degradation leads to accumulation of TP53 and to cell cycle arrest. (medscape.com)
  • Results: Data suggest that RO-3306 protected postovulatory aging-mediated spontaneous exit from M-II arrest in a concentration-dependent manner. (cgrpreceptor.com)
  • Throughout development cells make the decision to proliferate, arrest or die. (dundee.ac.uk)
  • In addition, metabolic activity of the 5637 cells is rapidly impaired, and the cells arrest in cell cycle in response to cis-UCA. (biomedcentral.com)
  • In addition, metabolic activity of the 5637 cells was rapidly impaired, and cell cycle arrest was induced at 1-3% cis-UCA. (biomedcentral.com)
  • Progression through the cell cycle critically relies upon post-translational mechanisms including changes in activity of cell cycle kinases and phosphatases, and ubiquitin-mediated degradation of specific components once their function is complete. (elifesciences.org)
  • This review summarizes the characteristics of cell senescence and updates the molecular mechanisms underlying cell senescence. (degruyter.com)
  • Moreover, we also discuss the recent advances on the molecular mechanisms that can potentially regulate the development and progression of atherosclerosis. (degruyter.com)
  • Cyclin D3 functions to attenuate AR activity through defined mechanisms that include modulation of ligand-dependent conformational changes and modulation of chromatin binding activity. (nih.gov)
  • however, its efficacy and underlying molecular mechanisms in nonsmall cell lung cancer (NSCLC) are not well defined. (nih.gov)
  • Glucotoxicity and lipotoxicity are also potential mechanisms for diabetic complications, in addition to beta cell dysfunction. (medsci.org)
  • The beneficial effect of omega-3 fatty acids on atherosclerosis has been suggested to involve several mechanisms such as to induce anti-inflammatory and anti-arrhythmic effects, to improve the lipid profile by lowering triglyceride levels, to prevent plaque development, to promote plaque stabilization, and to inhibit platelet aggregation ( 6 ). (medsci.org)
  • To overcome this hurdle, characterization of the stem-cell niche is important for understanding the molecular mechanisms whereby stem cells differentiate or self-renew. (nature.com)
  • Thus, exploring the underlying molecular mechanisms associated with glioma progression and metastasis may contribute to discovering more effective treatment methods and targets. (biomedcentral.com)
  • Therefore, in the present study we examined detailed Rabbit Polyclonal to B-Raf (phospho-Thr753) efficacy and molecular mechanisms of p-DGA using androgen-dependent (LNCaP) and androgen-independent (22Rv1) PCA cells. (cancerdir.com)
  • However, the mechanisms underlying p27 regulation of the cell cycle have not been thoroughly researched. (omicsdi.org)
  • The current study was aimed at characterizing the molecular mechanisms underlying cis-UCA-mediated cytotoxicity in cultured cancer cells. (biomedcentral.com)
  • In the current study, we aimed at characterizing the molecular mechanisms underlying cis-UCA-mediated cytotoxicity to cultured cancer cells. (biomedcentral.com)
  • Herein, we assessed silibinin activity on prime endpoints and key molecular targets such as cell number, cell-cycle progression, and cell-cycle regulatory molecules in three cell lines representing different NSCLC subtypes, namely large cell carcinoma cells (H1299 and H460) and a bronchioalveolar carcinoma cell line (H322). (nih.gov)
  • Despite the understanding that cell cycle regulatory protein dysregulation may be involved in numerous malignant tumors [ 2 ], there is limited data that explores the role of these oncoproteins with survival data in MMMTs. (biomedcentral.com)
  • The model for the mammalian cell cycle * shows how the regulatory structure of the Cdk network results * in its temporal self-organization, leading to the repetitive, * sequential activation of the four Cdk modules that brings about * the orderly progression along cell-cycle phases. (nih.gov)
  • Activation of the cellular senescence genetic program prompts a series of molecular changes, mostly affecting cell cycle, extracellular matrix (ECM), secretion of growth factors, and inflammatory mediators. (hindawi.com)
  • Prostate cancer (PCa) cell proliferation is dependent on activation of the androgen receptor (AR), a ligand-dependent transcription factor. (nih.gov)
  • Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. (proteopedia.org)
  • They interact and construct complexes with cyclin-dependent kinase (CDK)4 or 6. (nih.gov)
  • CKIs bind and inhibit the activity of cyclin/Cdk complexes and negatively regulate cell cycle progression (reviewed in Refs. (aacrjournals.org)
  • Abemaciclib is the newest cyclin-dependent kinase 4/6 inhibitor to gain Food and Drug Administration (FDA) approval, specifically as monotherapy for hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer previously treated with chemotherapy and endocrine therapy. (nih.gov)
  • Test the safety of Abemaciclib when given to participants with small cell lung cancer (SCLC). (mycancergenome.org)
  • Subjects will receive Abemaciclib (200 mg), orally every 12 hours on days 1 to 28 of a 28-day cycle for a total of 56 doses per cycle. (mycancergenome.org)
  • The intent-to-treat population of 669 patients was randomized to receive abemaciclib or placebo orally twice a day on a continuous dosing schedule, given in combination with fulvestrant at its approved dose and schedule, until disease progression. (lilly.com)
  • Several target genes of miR-137 have been documented and shown to play important roles in various human cancers, cell cycle signalling and mouse embryonic stem cell development. (wikipedia.org)
  • identified a list of 32 genes targeted by miR-137 by cross-referencing the global gene expression analysis of HCT 116 colorectal carcinoma cells after transfection of miR-137 with the list of predicted miR-137 targets via miRecords database. (wikipedia.org)
  • Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
  • To profile GSKJ4-target genes, we performed RNA sequencing for both normal and demethylase-inhibited cells. (molcells.org)
  • Functional annotations of all of the differentially expressed genes revealed that a significant number of genes were associated with the suppression of cellular proliferation, cell cycle progression and induction of cell death. (molcells.org)
  • Melanin biosynthesis genes were solely expressed in the cells of melanocytic origin, indicating the feasibility of using the PET approach for transcriptome comparison. (biomedcentral.com)
  • Potentially functional polymorphisms in cell cycle genes and the survival of non-small cell lung cancer in a Chinese population. (cdc.gov)
  • Cross-disease analysis identified novel common genes for both lung adenocarcinoma and lung squamous cell carcinoma. (cdc.gov)
  • At the molecular level, in fact, a gradual weakening of the cellular processes regulating cardiovascular homeostasis occurs in aging cells. (hindawi.com)
  • Site-specific DNA binding by p53 in RLE, HTB 125, HTB 133, and MCF-7 cells was increased when they were treated with Red No. 3, which suggests that cellular DNA was damaged by this colorant. (researchgate.net)
  • Cellular senescence is a process in which various stressors permanently stop cell division, resulting in cell changes that appear as senescent-associated secretory phenotype (SASP) ( 2 ). (medsci.org)
  • Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). (proteopedia.org)
  • The recovery of physiological functionality, which is commonly seen in tissue mimetic three-dimensional (3D) cellular aggregates (organoids, spheroids, acini, etc.), has been observed in cells of many origins (primary tissues, embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and immortal cell lines). (mdpi.com)
  • The etiologies of CC remains unknown, but in most cases CC are associated with chronic biliary inflammation, cellular injury of bile ducts together with obstruction of bile flow [ 6 , 7 ]. (gastrores.org)
  • Our data indicate that GSK-J4 affects cellular biology by inhibiting cellular proliferation through cell cycle suppression and induction of cell death. (molcells.org)
  • Cell death was assessed by measuring caspase-3 activity, mitochondrial membrane polarization, formation and release of cytoplasmic histone-associated DNA fragments, and cellular permeabilization. (biomedcentral.com)
  • Our studies elucidate how cis-UCA modulates several cellular processes, thereby inhibiting the proliferation and survival of bladder carcinoma cells. (biomedcentral.com)
  • These profiled libraries define drug-kinase networks that can predict the effectiveness of untested drugs and elucidate the roles of specific kinases in different cellular systems. (biomedcentral.com)
  • Predictions of drug effectiveness based on a comprehensive network model of cellular signalling are difficult, due to our partial knowledge of the complex biological processes downstream of the targeted kinases. (biomedcentral.com)
  • Patients aged 18-70 with this diagnosis who have not responded to first-line treatments for their advanced disease are eligible for a phase 2 National Cancer Institute study testing autologous T-cell receptor (TCR) gene therapy. (medscape.com)
  • Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. (nih.gov)
  • Regulation of both the cell cycle and gene transcription is essential for orderly progression of cell growth and division. (embl-heidelberg.de)
  • 3 Amplification of the MycN gene is found predominantly in advanced stage diseases and is associated with rapid tumor progression and poor prognosis [ 2 , 4 - 6 ]. (medsci.org)
  • For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
  • It uses mRNAs from a given cell line or tissue to generate a labeled target sample, which is hybridized to a large number of DNA sequences, each representing a gene. (biomedcentral.com)
  • Atherosclerosis and heart failure are particularly correlated with aging-related cardiovascular senescence, that is, the inability of cells to progress in the mitotic program until completion of cytokinesis. (hindawi.com)
  • Pathologies, as atherosclerosis, cardiac fibrosis, and cardiomyopathy, are often linked to the failure of cardiovascular tissue cells to reenter the cell cycle, namely, senescence, due to endogenous or exogenous causes. (hindawi.com)
  • This review will focus on the cardiovascular pathologies correlated to senescence, the effect of aging on the cardiac endogenous resources of stem cells, and the potential strategies of regenerative medicine to be applied to maintain the heart younger and healthier. (hindawi.com)
  • Mitotic cells might undergo senescence by failing to replicate. (hindawi.com)
  • While it is commonly accepted as an aging-related phenomenon, senescence might happen also during the embryonic development with the biological meaning of replacing transient structures or specific cell types with other ones [ 3 - 5 ]. (hindawi.com)
  • Cell senescence is a fundamental mechanism of aging and appears to play vital roles in the onset and prognosis of cardiovascular disease, fibrotic pulmonary disease, liver disease and tumor. (degruyter.com)
  • Moreover, an increasing body of evidence shows that cell senescence plays an indispensable role in the formation and development of atherosclerosis. (degruyter.com)
  • It also includes the stress responsive protein p38MAPK (mitogen-activated protein kinase 14) known to be involved in the regulation of senescence. (biomedcentral.com)
  • In particular, how cells are induced to senescence upon DNA damage attracted a lot of attention, this phenotype being associated to tumour suppression [ 9 ]. (biomedcentral.com)
  • We aimed to examine whether EPA could protect vascular endothelial cells under stress conditions against stress-induced accelerated senescence (SIAS). (medsci.org)
  • miR-137 is shown to regulate neural stem cell proliferation and differentiation in mouse embryonic stem cells, and neuronal maturation, including regulation of dendrite length, branch points, end points, and spine density in mouse adult hippocampal neuroprogenitor-derived and mouse fetal hippocampus neurons. (wikipedia.org)
  • Cyclin D3 action in androgen receptor regulation and prostate cancer. (nih.gov)
  • Recent studies have demonstrated that glioma-associated mesenchymal stem cells (GA-MSCs) are implicated in the regulation of glioma malignant progression. (biomedcentral.com)
  • Rat is an interesting model to study meiotic cell cycle regulation due to some peculiarities [4]. (cgrpreceptor.com)
  • also comprises p53 together with cell cycle regulation allowing to investigate the impact of DNA damage intensities on cell cycle progression [ 14 ]. (biomedcentral.com)
  • Like the mutations that cause multiple endocrine neoplasia type 4, these genetic changes reduce the amount of functional p27 available to control cell division. (medlineplus.gov)
  • The definition of positive outcome depends on the patient's assigned treatment but is most commonly progression-free survival (PFS) or overall response rate (ORR). (medscape.com)
  • The primary outcome measure is progression-free survival. (medscape.com)
  • The primary end point was progression-free survival (PFS). (psu.edu)
  • Progression Free Survival (PFS)assessed at 6 months and Overall Survival (OS). (mycancergenome.org)
  • Conventional chemotherapy and radiation therapy have not been shown to be effective in prolonging long-term survival and although photodynamic therapy has been reported to be effective as a palliative treatment, it is not curative [ 6 ]. (gastrores.org)
  • We then explored associations between cell cycle protein expression, mutational status, histologic features, and overall survival. (omicsdi.org)
  • For these patients who progressed on endocrine therapy, there was a significant prolongation of progression-free survival, and more than double the response rate, including an increased rate of complete response. (lilly.com)
  • During a replicative cycle, CRK5 stably interacts with a single Plasmodium -specific cyclin (SOC2), although we obtained no evidence of SOC2 cycling by transcription, translation or degradation. (elifesciences.org)
  • Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. (umbc.edu)
  • A protein recognition domain functioning in cell-cycle and transcription control. (embl-heidelberg.de)
  • The cyclin box fold: protein recognition in cell-cycle and transcription control. (embl-heidelberg.de)
  • As a transcription factor whose expression is increased by DNA damage, p53 blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)
  • The expression of hsa_circRNA_101996, microRNA (miR)-143, and ten-eleven translocation (TET)-2 in GC tissues, the adjacent tissues, and cell lines were determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). (jcancer.org)
  • a family of transcription activators involved in cell cycle specific transcription. (nih.gov)
  • To investigate the effect and molecular mechanism of vitexicarpin on the biological behavior of colorectal cancer cells is the objective of the study. (ijpsonline.com)
  • Cultured human umbilical vein endothelial cells (HUVECs) were exposed to H 2 O 2 as oxidative stress and a high glucose concentration with palmitate as a glucolipotoxic condition. (medsci.org)
  • This novel metronomic multimodal treatment protocol combines two molecular-targeted drugs, the mTOR-inhibitor Rapamycin and the multi-kinase inhibitor and immunosuppressant Dasatinib with conventional chemotherapy, consisting of the topoisomerase inhibitor irinotecan and the alkylating agent temozolomide. (medsci.org)
  • as monotherapy for the treatment of adult patients with HR+, HER2- advanced or MBC with disease progression following ET and prior chemotherapy in the metastatic setting. (lillymedical.com)
  • The accomplishment of the program was brought about through the decipherence of the chemical structure of taxol from Taxus brevifolia by the research group of Wani, Wall and coworkers in the year 1970 under a contract of Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health, United States of America 6 . (ijpsr.com)
  • The use of cis-UCA as an anticancer agent against non-muscle-invasive bladder cancer has previously been evaluated in cultured moderately and poorly differentiated human transitional bladder cancer cells using a short term (up to 2 h) pulse treatment model in vitro , which mimics the clinical intravesical chemotherapy regimen [ 3 ]. (biomedcentral.com)
  • This phytochemical has been shown to inhibit the growth of LNCaP human prostatic cancer cells in culture (IC50 = 50 ?M). It also has been shown to reduce one of the most fundamental biomarkers for prostate cancer, PSA, as well as modulate other proliferation and cell cycle related factors including PCNA, p21 (WAF1) and p27 (Kip1). (nih.gov)
  • This study, proposed a molecular mechanism that represented a possible unique relationship between AA intoxication, miRNAs expression, and the progression of UTUC in patients with BEN. (edu.mk)
  • Together, for the first time, these results identify potential molecular targets and anticancer effects of silibinin in NSCLC cells representing different NSCLC subtypes. (nih.gov)
  • Some cancer cells develop because their cells overrun the molecular brakes that normally permit cell to divide only when they are needed to replace old ones. (mycancergenome.org)
  • Waetzig R, Matthes M, Leister J, Penkivech G, Heise T, Corbacioglu S, Sommer G. Comparing mTOR inhibitor Rapamycin with Torin-2 within the RIST molecular-targeted regimen in neuroblastoma cells. (medsci.org)
  • ESCRT is the molecular machinery in eukaryotic cells that recognizes the ubiquitinated cargo at the intraluminal vesicles (ILVs) and sorts them into late endosomes to form multivesicular bodies (MVBs). (biomedcentral.com)
  • Expanding these findings to several factors influencing other processes of prostate cancer cells will clarify if AR can serve as a molecular target or surrogate marker for nutrients. (nih.gov)
  • Int J Radiat Biol 54(6):911-9282903889. (nih.gov)
  • Curr Opin Cell Biol 13(6):738-74711698191. (nih.gov)
  • Evidence suggests that vitamin D in our body may be negatively associated with the development and/or progression of several cancers including prostate cancer [10, 11].As discussed below, although experimental results from in vitro and preclinical models showed strong support of antiprostate cancer activities of this vitamin, epidemiological studies and clinical trials on human subjects hardly produce unanimous agreements for the potential of antiprostate cancer efficacy. (vitamindwiki.com)
  • This evidence came from numerous epidemiological studies, clinical trials, in-vitro cell culture experiments as well as experiments in animal models. (sdstate.edu)
  • GA-MSCs are a kind of stromal cell subset isolated from glioma tissue that show plastic and adherent morphology in vitro without tumorigenicity in vivo. (biomedcentral.com)
  • The function of the ESCRT subunits in glioma cells was examined in vitro. (biomedcentral.com)
  • The method uses the in vitro cell response of single drugs and drug pair combinations as a training set to build linear and nonlinear regression models. (biomedcentral.com)
  • In this paper, we introduce a novel computational method that incorporates profiled libraries and in vitro measurements to predict the response of cells to previously untested drugs. (biomedcentral.com)
  • IBRANCE (Palbociclib) a cyclin-dependent kinase (CDK) inhibitor which is selective for CDK 4 and 6. (advochealth.com)
  • 11] Acting downstream of SYK, Bruton tyrosine kinase (BTK) is a promising target in a variety of B-cell malignancies, including MCL. (cancernetwork.com)
  • ER beta from the prostate has a high affinity for genistein, a major soy isoflavone, which has several biological effects including a protein tyrosine kinase (PTK) inhibitor, an antioxidant, an inhibitor of angiogenesis, a blocker of topoisomerase II, an arrester of the cell cycle at the G2/M stage as well as acting as a phytoestrogen. (nih.gov)
  • Our results provide evidence that during Plasmodium male gametogony, this divergent cyclin/CDK pair fills the functional space of other eukaryotic cell-cycle kinases controlling DNA replication. (elifesciences.org)
  • activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. (proteopedia.org)
  • a component of the pre-replication complex which is essential for recruiting the MCM helicase complex to the Origin Recognition Complex (ORC) during the G1 phase of the cell cycle. (nih.gov)
  • also called Cdc7) a kinase that is essential for initiation of DNA replication. (nih.gov)
  • a protein that binds to the Cdt1 component of the pre-replication complex and inactivates it, preventing assembly of the pre-replication complex at inappropriate times during the cell cycle. (nih.gov)
  • Incorporating the DNA replication checkpoint mediated by kinases * ATR and Chk1 slows down the dynamics of the cell cycle without * altering its oscillatory nature and leads to better separation * of the S and M phases. (nih.gov)
  • It was previously established that cyclins D1 and D3 have the potential to modulate AR, and with regard to cyclin D1, disruption of this function occurs in human tumors. (nih.gov)
  • OBJECTIVES:Dysregulation of the cell cycle has been observed and implicated as an etiologic factor in a range of human malignancies, but remains relatively unstudied in neuroendocrine tumors (NETs). (omicsdi.org)
  • Patients enrolled in the study had experienced disease progression on or within 12 months of receiving endocrine treatment in the neoadjuvant or adjuvant setting or while receiving first-line endocrine therapy for metastatic disease. (lilly.com)
  • further showed that miR-137 targets Cdc42 (cell division cycle 42), a well-known member of the Rho GTPase family found be upregulated in many human cancer types such as colorectal, testicular and breast cancers. (wikipedia.org)
  • Neuroblastoma, derived from primitive nervous sympathetic cells, is the most common solid tumor of childhood and constitutes 7 % of all pediatric cancers [ 1 , 2 ]. (medsci.org)
  • This protein is found in cells and tissues throughout the body. (medlineplus.gov)
  • Analysis of promoter methylation in oral rinses of patients with squamous cell carcinoma of the head and neck showed that miR-137 methylation is associated with female gender and inversely associated with body mass index. (wikipedia.org)
  • or fulvestrant in patients with disease progression following endocrine therapy. (advochealth.com)
  • Methods: In this double-blind study, patients with relapsed or refractory SCLC were stratified by relapse type (sensitive versus resistant or refractory) and brain metastases and randomized 1:1 to alisertib/paclitaxel or placebo plus paclitaxel (henceforth referred to as placebo/paclitaxel) in 28-day cycles. (psu.edu)
  • On the other hand, it has been reported that exposure to some xenoestrogens and to estrogenic metabolites promotes the production of free radicals through the hydrogen peroxide (H 2 O 2 ) reduction cycle, by means of the P 450 oxidase and reductase enzymes, giving origin to the production of oxygen reactive species which might damage the genetic material [33]. (researchgate.net)
  • MicroRNAs (miRNA) regulate several biological processes, including cell proliferation, differentiation, and metabolism, acting as oncogenes or tumor suppressors. (edu.mk)
  • 9. microRNA-146a Promotes Growth of Acute Leukemia Cells by Downregulating Ciliary Neurotrophic Factor Receptor and Activating JAK2/STAT3 Signaling. (nih.gov)
  • The pesticide DDT and the food colorant Red No. 3 were found to increase the growth of HTB 133 but not estrogen receptor (ER) negative human breast cells (HTB 125) or rat liver epithelial cells (RLE). (researchgate.net)
  • Although laboratory studies including the use of animal models have shown that vitamin D has antiprostate cancer properties, whether it can effectively prevent the development and/or progression of prostate cancer in humans remains to be inconclusive and an intensively studied subject. (vitamindwiki.com)