Cell cycle progression cell cycle or cell. Medical search. Frequent questions

The N-terminal phosphorylation of RB by p38 bypasses its inactivation by CDKs and prevents proliferation in cancer cells. (nature.com)
Ammonia inhibits proliferation and cell cycle progression at S -phase in human gastric cells . (nih.gov)
In the cell proliferation test in vitro, E2 or BPA increased the growth of the BG-1 ovarian cancer cells expressing ERs. (endocrine-abstracts.org)
Their proliferation activity was reversed by the treatment of ICI 182,780, a well-known antagonist of ERs, which demonstrates that the cell proliferation by E2 or BPA is mediated by ERs and BPA certainly acts as a xenoestrogen in the BG-1 ovarian cancer cells. (endocrine-abstracts.org)
In this study, genistein effectively suppressed the BG-1 cell proliferation induced by E2 or BPA by adversely down regulating the cell cycle progression that was upregulated by E2 or BPA. (endocrine-abstracts.org)
The siRNA-mediated DEPDC1 depletion resulted in significant inhibition of proliferation and delay in cell cycle progression in both NPC cell lines, CNE-1 and HNE-1. (oncotarget.com)
In contrast to THF, which induced a marked reduction in the number of cells in S phase and in the extent of PCNA immunolabeling, DPPC liposomes proved to be an effective delivery system that does not interfere with cell proliferation. (unipv.it)
Increased CaM caused a transient acceleration of proliferation, while the anti-sense RNA induced decrease in CaM caused a transient cell cycle arrest. (duke.edu)
When the re-oxygenation phase is sufficiently long, our model predicts that cyclic hypoxia simply slows cell proliferation since cells spend more time in the S phase. (ox.ac.uk)
On the contrary, cycles with short periods of re-oxygenation are predicted to lead to inhibition of proliferation, with cells arresting from the cell-cycle when they exit the S phase. (ox.ac.uk)
High expression of MRPL13 promotes cell cycle progression and proliferation of gastric cancer cells by inhibiting p53 signaling to affect long-term prognosis]. (bvsalud.org)
We further assessed the effects of MRPL13 overexpression and knockdown on proliferation and cell cycle of gastric cancer MGC-803 and SGC-7901 cells in vitro and on subcutaneous xenograft growth in nude mice . (bvsalud.org)
MRPL13 is highly expressed in gastric cancer and affects the long- term prognosis of the patients possibly by inhibiting p53 signaling to promote cancer cell proliferation and cell cycle progression. (bvsalud.org)
To date, very little is known concerning the role of the endocannabinoids in the control and regulation of cell proliferation. (unisa.it)
Furthermore, liver regeneration, a useful in vivo model of synchronized cell proliferation, is characterized by a peak of anandamide that elicits through CB1 receptor, the expression of critical mitosis genes. (unisa.it)
These results support the notion that the signaling mediated by anandamide through CB1 receptor may be important for the entry and progression of cells into the cell cycle and hence for their proliferation under mitogenic signals. (unisa.it)
Through analysis of in vivo cell proliferation, we demonstrated that the ensuing depletion of DP thymocytes was secondary to a decreased commitment of resident pro-T and pre-T cells to enter the cell cycle. (ox.ac.uk)
These findings suggested that thymic atrophy in acute GVHD is effected by impaired cellular proliferation of immature host thymocytes and that the failure of these cells to enter the cell cycle is dependent on an interferon (IFN)-gamma-driven immune response. (ox.ac.uk)
We hypothesized that FXR and FMD may inhibit proliferation and the metastatic phenotype in PC-3 prostate cancer cells. (edu.iq)
In addition, differences in the proliferation rates of cells within a malignancy may shape their proliferation or metastatic potential. (genengnews.com)
Moreover, in adults, Merkel cells undergo slow turnover and are replaced by cells originating from epidermal stem cells, not through the proliferation of differentiated Merkel cells. (medscape.com)
Downregulation of CDCA5 Can Inhibit Cell Proliferation, Migration, and Invasion, and Induce Apoptosis of Prostate Cancer Cells. (nih.gov)
We also showed that dose-dependent induction of proliferation was connected with changes in the expression of MKI67, CCND1 and CCNE1 genes in well- and poorly differentiated cancer cells. (spandidos-publications.com)
Our study revealed that Ang II influences EC cells in terms of cancer-related processes, and is responsible for increased proliferation, reduction in apoptosis, increased mobility and modulation of adhesion potential. (spandidos-publications.com)
Therefore, various biologically active peptides such as angiotensin, affecting cell proliferation, have become a new area of study in endometrial cancer research. (spandidos-publications.com)
Recently, a number of studies have shown that Ang II plays an important role in proliferation, invasiveness and migration of tumour cells, alteration of expression of cancer-related genes, as well as in physiological tissue remodelling. (spandidos-publications.com)
Results and Conclusions: The adaptation process was characterized by initial cell population growth arrest, and after that extensive cell death, followed by proliferation and long-term survival of clonal cultures. (lu.se)
Proliferation and cell cycle progression of the serum-free cultures closely mimicked that of serum-dependent cells. (lu.se)
ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)

Epidemiologic, animal, and laboratory studies suggest that 5-amino-salicylic acid (5-ASA) protects from the development of CRC by altering cell cycle progression and by inducing apoptosis. (nih.gov)
Embryos lacking E4F die at the peri-implantation stage, while in vitro-cultured E4F(-/-) blastocysts exhibit defects in mitotic progression, chromosomal missegregation, and increased apoptosis. (cnrs.fr)
HRas and Myc synergistically induce cell cycle progression and apoptosis of murine cardiomyocytes. (cam.ac.uk)
Resveratrol could play a toxic role through inducing apoptosis of the cancer cell in a time- and concentration-dependent manner. (mdpi.com)
Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma. (nih.gov)
Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non-small cell lung cancer cells via p53-p21 signaling pathway. (nih.gov)
Most changes were subtle, but frequently the genes with altered expression were involved in basal cellular functions such as cell division, cell cycle regulation, apoptosis and cell signalling. (lu.se)

continue for maximum of 6 cycles or until disease progression or unacceptable toxicity occurs. (medscape.com)

Our results establish a crucial role for E4F during early embryonic cell cycles and reveal an unexpected function for E4F in mitosis. (cnrs.fr)
Here we show that cell cycle progression through mitosis following double-stranded DNA breaks leads to the formation of micronuclei, which precede activation of inflammatory signalling and are a repository for the pattern-recognition receptor cyclic GMP-AMP synthase (cGAS). (nature.com)
Inhibiting progression through mitosis or loss of pattern recognition by stimulator of interferon genes (STING)-cGAS impaired interferon signalling. (nature.com)
Figure 2: Progression through mitosis underlies inflammatory pathway activation. (nature.com)
Oscillations of Cdk1/CycB activity between low and high levels during the cycle trigger DNA replication and mitosis in the correct order. (ox.ac.uk)
Scholars@Duke publication: Calmodulin is required for cell-cycle progression during G1 and mitosis. (duke.edu)
Flow cytometric analysis showed that progression through G1 and mitosis was affected by changes in CaM levels. (duke.edu)

Propidium iodide flow cytometry was used to determine cell cycle progression in HEK293T and HCT116 cells under hsa-miR-587 (miR-587) overexpression circumstances. (celljournal.org)
Overexpression of miR-587 in HEK293T and HCT116 cells resulted in downregulation of TGFBR2 and SMAD4 genes. (celljournal.org)
Moreover, miR-587 overexpression in HEK293T and HCT116 cells resulted in reducing the SubG1 cell populations in both cell lines, as detected by flow cytometry. (celljournal.org)
GTF2IRD1 overexpression promotes tumor progression and correlates with less CD8+ T cells infiltration in pancreatic cancer. (nih.gov)
Moreover, overexpression of this cyclin was found to be a prognostic factor determining resistance to fulvestrant and shorter progression-free survival. (lu.se)

System-level feedbacks control cell cycle progression. (ox.ac.uk)
Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. (bvsalud.org)

At the cellular level, FXR activation resulted in down-regulation of procaspase -3, vimentin, and MMP9, which triggers apoptotic cell death, cell cycle arrest, and switch from mesenchymal to an epithelial phenotype. (edu.iq)
With the advent of improved immunohistochemical profiling, the tumor was reclassified as Merkel cell carcinoma because shared epithelial and neuroendocrine markers, along with ultrastructural features suggestive of neural crest origin, were observed in both the constituent tumor cell and the physiologic Merkel cell of the skin. (medscape.com)
Within skin, Merkel cells have also been shown to cluster in the basal layers of the interfollicular epidermis in specialized epithelial structures called touch domes, where they are juxtaposed with epidermal keratinocytes. (medscape.com)
[ 5 , 6 ] Furthermore, experiments have demonstrated that epidermal progenitors in the touch domes are capable of producing Merkel cell lines and that epithelial progenitor populations in adults have the capacity to give rise to both neuroendocrine and squamous lineages. (medscape.com)
Other suggested cells of origin include the neural crest‒derived cell of amine precursor uptake and decarboxylation (APUD) system, dermal fibroblasts, pre or pro B cells, residual epidermal stem cells, and epithelial, non-Merkel cell progenitors. (medscape.com)
While much work has focused on the failure of epithelial cell populations as a key component of the aging process, additional studies have shown that aging, as a global phenomenon in the lung, also impacts resident endothelial, mesenchymal, and immune cell populations. (karger.com)
K17 was not detected in the epithelial cells of benign glandular lesions, but groups of cuboidal cells, residing beneath the epithelial layer of benign glands, were frequently positive for K17, especially in cases of microglandular hyperplasia. (medscape.com)

In this study, we hypothesized that 5-ASA restrains cell cycle progression by activating checkpoint pathways in colorectal cell lines, which would prevent tumor development and improve genomic stability. (nih.gov)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Further analyses identified previously unrecognized AR functions in major pathways associated with clinical PCa progression. (ox.ac.uk)
Illustrating the impact of these unmasked AR-driven pathways, dihydroceramide desaturase 1 was identified as an AR-regulated gene in mitotically active cells that promoted pro-metastatic phenotypes, and in advanced PCa proved to be highly associated with development of metastases, recurrence after therapeutic intervention and reduced overall survival. (ox.ac.uk)
Blocking of CB1 receptor with a low dose of the selective antagonist/inverse agonist SR141716 (0.7 mg/kg/dose) affected cell cycle progression reducing the expression of PCNA, and through the inhibition of pERK and pSTAT3 pathways. (unisa.it)
Dr. Shen's research has been focused on the roles for cell growth signaling pathways (including RAS-MAPK and PI3K-mTOR) in the regulation of cell cycle progression and DNA damage repair. (cityofhope.org)
Even as the nature of the exact cell in which Merkel cell carcinoma oncogenesis occurs is controversial, there is strong support for the notion that Merkel cell carcinoma results from of one of two distinct pathways. (medscape.com)
In this review, we examine aging as a process dependent on specific changes in molecular pathways within multiple lung cell populations. (karger.com)

In contrast, sustained AhR activation in response to TCDD treatment increases p27 Kip1 expression in addition to P4501A1, resulting in G 1 phase cell cycle arrest. (aspetjournals.org)
Treating serum-released 5L cells with the alkyne metabolism-based P4501A1 inhibitor 1-(1-propynyl)pyrene results in prolonged AhR activation, enhanced p27 Kip1 expression, and G 1 phase arrest after serum release. (aspetjournals.org)
The data are consistent with a cell cycle role for P4501A1 because they show that P4501A1 negatively regulates the duration of AhR action through the metabolic removal of the receptor agonist, thereby preventing AhR-mediated G 1 phase arrest. (aspetjournals.org)
Concretely, E2 or BPA decreased the gene expression of p21, which is a potent cyclin-dependent kinase (Cdk) inhibitor and responsible for the cell cycle arrest at G1 phase, to proliferate the BG-1 cells. (endocrine-abstracts.org)
Detailed analysis with indirect immunofluorescence assays revealed that DEPDC1 depletion caused significant mitotic arrest accompanied with mitotic defects such as multipolar spindles and multiple nuclei followed by apoptotic cell death. (oncotarget.com)
SIRT1 depletion induces CHK2 hyperactivation-mediated cell cycle arrest and subsequent cell death. (ewha.ac.kr)
A distinguishing feature of our model is the inclusion of impaired DNA synthesis and cell-cycle arrest due to periodic exposure to severely low oxygen levels. (ox.ac.uk)
Reprimo (RPRM), a downstream effector of p53-induced cell cycle arrest at G2/M, has been proposed as a putative tumor suppressor gene (TSG) and as a potential biomarker for non-invasive detection of gastric cancer (GC). (pucv.cl)
Moreover, our study showed that INT 747 either alone or combined with FMD robustly induced cell cycle arrest at the S phase. (edu.iq)

Cell Death and Differentiation , 15. (strath.ac.uk)
Allowing the comparison of the RNA populations found in differentiation to axenic amastigotes in vitro, to those of the amastigote forms infecting a host cell. (gla.ac.uk)
Cell Death and Differentiation , 27 (2), 482-496. (ewha.ac.kr)
Studies suggest that p27 is also involved in controlling cell differentiation, which is the process by which cells mature to carry out specific functions. (medlineplus.gov)
miR-203 drives breast cancer cell differentiation. (medscape.com)
Its effect and effectiveness appear to be highly connected with the differentiation status of the cancerous cells, as Ang II appears to play a crucial role in the early and late stages of malignant transformation. (spandidos-publications.com)

Figure 3: Relocalization of cGAS to micronuclei following mitotic progression triggers inflammatory signalling. (nature.com)

To understand this process, we examined the effects of ammonia on the growth and cell cycle progression of human gastric cancer cell lines (HGC-27, MKN1, MKN45) using flow-cytometric analysis. (nih.gov)

The androgen receptor (AR) is required for prostate cancer (PCa) survival and progression, and ablation of AR activity is the first line of therapeutic intervention for disseminated disease. (ox.ac.uk)
In this study, INT 747 treatment caused apoptotic morphological changes and significantly reduced the survival of PC-3 cells incubated in normal mediums. (edu.iq)
Collectively, FXR activation alone markedly decreases, and when combined with FMD abrogates the survival and carcinogenic potential of metastatic prostate cancer cells. (edu.iq)
[ 11-13 ] By contrast, we discovered, using laser capture microdissection and mass spectrometry, that keratin 17 (K17) could predict the overall survival of patients with cervical squamous cell carcinoma more accurately than grade, stage, or any other clinicopathologic features. (medscape.com)

This study was designed to show whether ammonia has an effect on the cell - cycle progression in human gastric cells in vitro. (nih.gov)
While fluctuating oxygen environments can be reproduced in vitro, the range of oxygen cycles that can be tested is limited. (ox.ac.uk)
Accordingly, in this paper we develop a mechanistic model of the cell-cycle that can be combined with in vitro experiments, to better understand the link between cyclic hypoxia and cell-cycle dysregulation. (ox.ac.uk)
Comparative potency of obeticholic acid and natural bile acids on FXR in hepatic and intestinal in vitro cell models. (edu.iq)
Objective: Serum is usually added to growth media when mammalian cells are cultured in vitro to supply the cells with growth factors, hormones, nutrients and trace elements. (lu.se)

Mechanistically, EPIC1 promotes cell-cycle progression by interacting with MYC through EPIC1's 129-283 nt region. (prinsesmaximacentrum.nl)

In the article titled "miR-486 Promotes the Invasion and Cell Cycle Progression of Ovarian Cancer Cells by Targeting CADM1" [ 1 ], the author list is revised as above by removing Yue Wang and Bowen Wang and updating the order of authors. (hindawi.com)
miR-486 Promotes the Invasion and Cell Cycle Progression of Ovarian Cancer Cells by Targeting CADM1," Analytical Cellular Pathology , vol. 2021, Article ID 7407086, 13 pages, 2021. (hindawi.com)
In this study, we examined the effect of a phytoestrogen, genistein, on the cell growth of BG-1 ovarian cancer cells expressing estrogen receptors (ERs) caused by E2 and BPA. (endocrine-abstracts.org)

The aim of this study was to focus on the timing of endocannabinoid signaling changes during the different phases of the cell cycle, exploiting the rat liver regeneration model following partial hepatectomy, the most useful to study synchronized cell cycle in vivo. (unisa.it)
Consequently, there was a lack of apparent structural changes, a restricted in situ transcription of inflammatory cytokines, and a virtually unchanged cell cycle progression in vivo. (ox.ac.uk)
Using ex vivo thymocytes and primary embryonic fibroblasts from Epm2a -/- mice, we show here a general function of laforin in the cell cycle regulation and repression of cyclin D1 expression. (elsevierpure.com)

Cell cycle progression was evaluated by immunofluorescence detection and flow cytometric analysis of the proliferating cell nuclear antigen (PCNA). (unipv.it)
All patients can evolve into trisomy 8+ MDS [12], cells, since acquiring adequate samples diagnosed with MDS have a reduced in which 8+ appears to confer a favour- for flow cytometric analysis renders the life expectancy compared with age- able prognosis [13]. (who.int)

Effects of pristine and nitrogen-doped multiwalled carbon nanotube s (ND-MWCNT) on reactive oxygen species (ROS) and cell cycle progression. (cdc.gov)

Our previous results indicate that 5-ASA improves replication fidelity in colorectal cells, an effect that is active in reducing mutations. (nih.gov)

1998. Protection of human upper respiratory tract cell lines against sulphur mustard toxicity by hexamethylenetetramine (HMT). (cdc.gov)

The cell cycle is a tightly regulated process that is controlled by the conserved cyclin-dependent kinase (CDK)-cyclin protein complex 1 . (nature.com)
Serum release of serum-starved (G 0 ) 5L rat hepatoma cells triggers transient AhR activation and P4501A1 protein expression concomitant with the G 0 /G 1 -to-S phase transition. (aspetjournals.org)
To validated how transient gene expression changes may be represented at the protein level, 96 fluorescently tagged cell lines were produced using a highthroughput CRISPR-Cas9 system. (gla.ac.uk)
The function of this protein in normal cell physiology remains largely unknown. (cnrs.fr)
Repetitive cell cycles, which are essential to the perpetuation of life, are orchestrated by an underlying biochemical reaction network centered around cyclin-dependent protein kinases (Cdks) and their regulatory subunits (cyclins). (ox.ac.uk)
Both the stress-response protein, SIRT1, and the cell cycle checkpoint kinase, CHK2, play critical roles in aging and cancer via the modulation of cellular homeostasis and the maintenance of genomic integrity. (ewha.ac.kr)
The biosynthesis performed by the BCCP protein allows for the transfer of CO2 within active sites of the cell. (wikipedia.org)
Upon addition of Zn2+, cells containing the BPV-MCM vector have transiently increased CaM mRNA and protein levels. (duke.edu)
Hepatic regeneration led to increased levels of anandamide and endocannabinoid-like molecules oleoylethanolamide (OEA) and palmitoylethanolamide (PEA) in the G1 phase of the cell cycle, with a concomitant increase in CB1 mRNA levels, whose protein expression peaked later during the S phase. (unisa.it)
This protein is found in cells and tissues throughout the body. (medlineplus.gov)
For example, when p27 is held (sequestered) in the fluid that surrounds the nucleus (the cytoplasm) instead of being transported into the nucleus, the protein is unavailable to block cell cycle progression. (medlineplus.gov)
studies suggest that certain endocrine cells may be particularly dependent on the p27 protein to control cell division. (medlineplus.gov)

The resulting profile, he noted, is "essentially like a fingerprint of each different cell in a particular sample. (genengnews.com)

Cell cycle progression, phosphorylation, and DNA binding of cell cycle checkpoint proteins were analyzed. (nih.gov)

Deregulation of AKT-mTOR signaling contributes to chemoradiation resistance in lung squamous cell carcinoma. (cityofhope.org)
LCL161, a SMAC-mimetic, Preferentially Radiosensitizes Human Papillomavirus-negative Head and Neck Squamous Cell Carcinoma. (cityofhope.org)
risk of esophageal squamous cell carcinoma. (who.int)
PMID:18786442 mutations and the risk of esophageal squamous cell carcinoma. (who.int)
Arbyn M, Bergeron C, Klinkhamer P, Martin-Hirsch squamous cell carcinoma in a high-risk region in Iran. (who.int)
Previous work in our laboratory identified keratin 17 (K17) as a specific and sensitive biomarker for high-grade squamous intraepithelial lesions and cervical squamous cell carcinoma (SCC). (medscape.com)
Cervical cancer has multiple histologic subtypes, with squamous cell carcinoma (SCC) accounting for approximately 75% of cases and invasive adenocarcinoma accounting for 10% to 15% of cases. (medscape.com)

CDCA5 promotes the progression of prostate cancer by affecting the ERK signalling pathway. (nih.gov)

Taken together, these results confirm the protective nature of Nrf2 in oxidative stress scenarios and suggest that the enhanced emphysematous phenotype exhibited by CS-exposed Nrf2(-/-) mice is more likely caused by an imbalance in cell loss and regeneration than by increased inflammation. (pmiscience.com)
Simultaneously, mature donor-derived T cells expanded in the confines of the allogeneic thymic microenvironment, leading to local inflammation. (ox.ac.uk)

Therefore, we developed an expression signature composed of genes involved in cell cycle progression (CCP) and tested its utility in prostate cancer. (aacrjournals.org)
This crucial life-cycle development stage of Leishmania within the macrophage revealed infection response associated genes, linked with parasite removal strategies. (gla.ac.uk)
Also, the alteration of p21 gene expression by E2, BPA, or genistein affected the expression of its downstream genes of cell cycle, cyclin D1 and Cdk-4. (endocrine-abstracts.org)
After that, quantitative real-time polymerase chain reaction (RT-qPCR) was used to detect the expression of miR-587, TGFBR2, SMAD4, p21, CCND1 and c-MYC genes in transfected HEK293T and HCT116 cells. (celljournal.org)
We characterized the epigenetic landscape of genes encoding long noncoding RNAs (lncRNAs) across 6,475 tumors and 455 cancer cell lines. (prinsesmaximacentrum.nl)
After Ang II treatment, poorly differentiated endometrial cancer cell line acquired a mesenchymal phenotype, which was characterized by induced expression of EMT-related genes (VIM, CD44, SNAI1, ZEB1 and ZEB2). (spandidos-publications.com)
Moreover, we examined alterations in the expression of genes related to cancer cell behaviour after Ang II treatment. (spandidos-publications.com)
Some alterations were restored when the cells were transferred back to serum-containing medium, indicating that expression of these genes was controlled by components in serum. (lu.se)
May be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T cells. (lu.se)

Breast metastatic tumors in lung can be substituted by lung-derived malignant cells transformed by alternative splicing H19 lncRNA. (medscape.com)
In adenocarcinomas, K17 staining was detected in a mean of 33.9% of malignant cells. (medscape.com)

Herceg, Z., Hulla W., Gell D., Cuenin C., Lleonart M., Jackson S. and Wang Z.Q. (2001) Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression. (who.int)

Cell-cycle events have been shown to be triggered by oscillations in the activity of cyclin dependent kinases (CDKs) when bound to cyclins. (duke.edu)
CONCLUSION: Co-expression of Cyclin T1 and Myc may be a therapeutically tractable approach for cardiomyocyte neo-genesis post injury, while cell death induced by HRas G 12 V and Myc expression likely limits this option as a regenerative therapeutic target. (cam.ac.uk)
Two models have been put forward for cyclin-dependent kinase (Cdk) control of the cell cycle. (crick.ac.uk)
In the qualitative model, cell cycle events are ordered by distinct substrate specificities of successive cyclin waves. (crick.ac.uk)
A single cyclin can also replace all G1 cyclins to support ordered cell cycle progression, fulfilling key predictions of the quantitative model. (crick.ac.uk)
However, single-cyclin cells fail to polarize or grow buds and thus cannot survive. (crick.ac.uk)
Our results suggest that budding yeast has become dependent on G1 cyclin specificity to couple cell cycle progression to essential morphogenetic events. (crick.ac.uk)
Glycogen synthase kinase 3β (GSK-3β) represses cell cycle progression by directly phosphorylating cyclin D1 and indirectly regulating cyclin D1 transcription by inhibiting Wnt signaling. (elsevierpure.com)

CDCA5 promotes the progression of breast cancer and serves as a potential prognostic biomarker. (nih.gov)

Further, I show that during a wild-type cell cycle, checkpoints are responsible for arresting the bulk of periodic transcription. (duke.edu)

Background: The transcription factor B-Myb is present in all proliferating cells, and in mice engineered to remove this gene, embryos die in utero just after implantation due to inner cell mass defects. (harvard.edu)

Dr. Shen's long-term goals is to elucidate the mechanisms of tumorigenesis and find better therapies for the aggressive and hard-to-treat tumors, such as pancreatic and lung cancers, by exploring the genetic and epigenetic alterations of cancer cells. (cityofhope.org)
Also see Merkel Cell Tumors of the Head and Neck and Merkel Cell Carcinoma and Rare Appendageal Tumors . (medscape.com)
The authors used artificial neural croarrays is to study changes in gene ex- .nature organ the tumor arose from, how big it networks (ANNs) to identify gene-ex- pression that accompany changes in is, and what it looks like after it has pression signatures associated with spe- cell physiology, such as during develop- been imbedded in wax and colored cific subtypes of tumors. (lu.se)
0 blue-cell tumors (SRBCTs), which type, 41 (including 7 expressed often masquerade as each other. (lu.se)

Taken together, these findings delineate AR function in mitotically active tumor cells, thus providing critical insight into the molecular basis by which AR promotes development of lethal PCa and nominate new avenues for therapeutic intervention. (ox.ac.uk)
they are not inherited and are present only in tumor cells. (medlineplus.gov)

HRas G 12 V and constitutive Myc expression together co-operate to drive cell-cycle progression of adult mammalian cardiomyocytes. (cam.ac.uk)

There is a growing body of scientific evidence that suggests the potential implication of periodontitis in the causation and progression of various systemic disease and conditions, such as diabetes, cardiovascular disease, pulmonary disease, adverse pregnancy outcomes and cancer. (intechopen.com)
Moxetumomab pasudotox is an anti-CD22 recombinant immunotoxin indicated for adults with relapsed or refractory hairy cell leukemia (HCL) who have received at least 2 prior systemic therapies, including a purine nucleoside analog. (medscape.com)

Interestingly, the combination treatment on PC-3 cells not only showed several lines of evidence of apoptotic cells death but also inhibited carcinogenic potential as evaluated by impairment of spheroid formation capacity and delayed wound healing and matrigel invasion. (edu.iq)
A small increase in early and late apoptotic events in irradiated MCF-7 cells was observed. (bvsalud.org)
High-risk MDS cases had a significantly higher percentage of apoptotic CD34+ cells and anti-apoptotic survivin+ cells than controls, particularly for trisomy 8 cases. (who.int)
Trisomy 8+ cells showed a significant positive correlation with apoptotic CD34+ cells and capacity for colony formation. (who.int)
Our results suggest that although trisomy 8 cells are in a pro-apoptotic state, they are checked by the enhanced expression of anti-apoptotic signals which provide them with their proliferative advantage. (who.int)
The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)

and regulation of cell cycle process. (nih.gov)

Even genetically identical cells may grow at different rates, as shown by experiments on bacteria and some eukaryotes. (genengnews.com)

These results suggest that in normal human fibroblasts, BC induces a cell cycle delay in the G1 phase and that this effect is independent of conversion to known retinoids. (unipv.it)

During aging, a decline in organ function can be traced to a loss of stem cell function due to increased cell turnover, depletion of stem cells, and alterations to the stem cell niche. (karger.com)

Analyses of the cell viability, cell cycle, migration, and matrigel invasion assays were performed to elucidate how INT 747 and /or FMD functions in prostate cancer. (edu.iq)
It is still necessary, however, to scale analyses and to capture as many cells as possible from a sample. (genengnews.com)

The second model proposes that a transcription factor (TF) network oscillator controls the timing of cell-cycle events, via proper timing of gene expression, including cyclins. (duke.edu)

Inhibiting BRAF Oncogene-Mediated Radioresistance Effectively Radiosensitizes BRAFV600E-Mutant Thyroid Cancer Cells by Constraining DNA Double-Strand Break Repair. (cityofhope.org)

Anandamide drives cell cycle progression through CB1 receptors in a rat model of synchronized liver regeneration. (unisa.it)
Moreover, both angiotensin receptors (AT1 and AT2) are overexpressed in different types of cancers, which confirms the role of local RAS in cancer development and progression ( 3 , 5 - 8 ). (spandidos-publications.com)

In this dissertation, I explore the mechanisms that coordinate and regulate cell-cycle progression in the budding yeast, Saccharomyces cerevisiae. (duke.edu)

By measuring global gene expression dynamics in cells with persistent CDK activity, I show that periodic transcription continues. (duke.edu)
To examine the timing and the patterns of gene expression over the life and cell cycle, pseudotime analysis was used for the first time in Leishmania, so that we may further explain the order of these transitional events and any potential stage specific patterns in gene expression, providing an unprecedented understanding of the life cycle transitions. (gla.ac.uk)
Importantly, in comparison to wt mice, an attenuated cell cycle/mitotic response and intensified stress gene expression pattern were observed in exposed Nrf2(-/-) mice, which was paralleled by clear dose-dependent effects on alveolar destruction and impaired lung function. (pmiscience.com)
The Human Cell Atlas relies, to a great extent, on the use of transcriptome sequencing to profile the gene expression of individual cells. (genengnews.com)
We developed a fast way of profiling tens of thousands of cells, where for each cell, we capture gene expression in an unbiased way," says Benjamin J. Hindson, Ph.D., CSO, president, and cofounder of 10x Genomics. (genengnews.com)
Cell Ranger is a set of analysis pipelines that processes Chromium single-cell 3′ RNA-Seq output to align reads, generate gene-cell matrices, and perform clustering and gene-expression analysis. (genengnews.com)
Biological assays and gene expression analysis were performed on three cell lines: ISH, MFE-296 and MFE-280. (spandidos-publications.com)

Effect of beta-carotene on cell cycle progression of human fibroblasts. (unipv.it)
The uptake of beta-carotene (BC) and its effect on the cell cycle progression of normal human fibroblasts in primary culture were investigated by using two different delivery methods: exposure to BC solubilized in the organic solvent tetrahydrofuran (THF) or to BC incorporated into dipalmitoylphosphatidylcholine (DPPC) liposomes. (unipv.it)
Carbon nanotube s promote lung tumor progression through the induction of cancer-associated fibroblasts and cancer stem-like cells. (cdc.gov)

Understanding the regulatory mechanisms that control cell-cycle events remains to be a fundamental question in cell biology. (duke.edu)
Here, the application of single cell RNA sequencing (scRNA-seq) was employed to investigate the fundamental biology behind transcriptomic changes as the parasite progresses through life cycle stages, from promastigote to metacyclic forms before differentiating into amastigotes. (gla.ac.uk)
Furthermore, these 91 cell lines of tagged hypothetical proteins provide the opportunity for further research into new biology. (gla.ac.uk)
This project aimed to provide an example of investigating fundamental Leishmania biology by applying scRNA-seq for the study of life and cell cycle transitions, with the application of pseudotime analysis for the first time. (gla.ac.uk)
Nature Reviews Molecular Cell Biology. (edu.iq)

New experimental data have shown how the periodic exposure of cells to low oxygen levels (i.e., cyclic hypoxia) impacts their progress through the cell-cycle. (ox.ac.uk)
This editorial highlights the relevance of interfering in cancer cell progression through the pharmacological manipulation on the cell metabolism of cyclic nucleotides such as cAMP, and on the intracellular Ca2+ signaling, which may avail the reduction of toxic effects promoted by chemotherapy, radiotherapy and immunotherapy, thus decreasing the incidence of interruption in antitumoral treatment. (researchgate.net)

Taken together, our data demonstrate that laforin is a selective phosphatase for GSK-3β and regulates cell cycle progression by GSK-3β-dependent mechanisms. (elsevierpure.com)

Notably, DEPDC1 depletion also reduces migration and invasion ability in both cell lines. (oncotarget.com)
At the cellular level, aging is marked by depletion of adult stem cell reservoirs, the inability to maintain baseline homeostasis, a reduced response to stress, an increased accumulation of damaged DNA leading to telomere shortening, and mitochondrial dysfunction [ 1,2 ]. (karger.com)

Molecularly, Cr(VI) carcinogenesis involves dysregulation of cell cycle signaling resulting in cells that become death resistant. (gwu.edu)

Like the mutations that cause multiple endocrine neoplasia type 4, these genetic changes reduce the amount of functional p27 available to control cell division. (medlineplus.gov)

Developmental changes in interkinetic nuclear migration dynamics with respect to cell-cycle progression in the mouse cerebral cortex ventricular zone. (sbri.fr)

Of the 96 cell lines produced, 91 were hypothetical proteins identified as having transient expression patterns for developmental trajectories drawn over promastigote to metacyclic and axenic amastigote stages. (gla.ac.uk)
In order to examine the consequences of a transient increase or decrease in intracellular calmodulin (CaM) levels, two bovine-papilloma-virus (BPV)-based expression vectors capable of inducibly synthesizing CaM sense (BPV-MCM) or anti-sense (BPV-CaMAS) RNA have been constructed and used to stably transform mouse C127 cells. (duke.edu)

We show that the enzymatic acetylation and deacetylation of a cell surface carbohydrate controls B cell development, signaling, and immunological tolerance. (harvard.edu)

Anatomy23

Organisms11

Diseases7

Chemicals and Drugs114

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes82

Disciplines and Occupations1

Information Science3

Health Care1

Proliferation29

Apoptosis7

Disease progression or unacceptable toxicity1

Mitosis7

Overexpression5

Control cell cycle progression2

Epithelial7

Pathways8

Arrest9

Differentiation6

Mitotic progression1

Gastric cancer1

Survival4

Vitro5

Promotes cell cycle1

Ovarian Cancer Cells3

Vivo3

Cytometric analysis2

Reactive oxygen1

Replication1

Toxicity1

Protein12

Fingerprint1

Phosphorylation1

Squamous7

Pathway1

Inflammation2

Genes9

Malignant2

Early embryonic1

Cyclin8

Prognostic1

Checkpoints1

Defects1

Tumors4

Tumor Cells2

Mammalian1

Systemic2

Apoptotic6

Regulation of cell cycle1

Eukaryotes1

Induces1

Alterations1

Analyses2

Cyclins1

Oncogene1

Receptors2

Budding yeast1

Gene expression7

Fibroblasts3

Biology5

Cyclic2

Mechanisms1

Depletion2

Carcinogenesis1

Endocrine1

Migration1

Transient2

Acetylation1