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  • cyclins
  • Additionally, if TEF3-1 was knocked down, the expression of cyclins and CDKs was downregulated while the expression of P21, a negative regulator of the cell cycle, was upregulated. (pubmedcentralcanada.ca)
  • perturbations
  • Cell kinetic perturbations that resulted in a wave of increased cell division during the 6--8 hr lag period prior to regenerative DNA replication in mouse epidermis were examined. (biomedsearch.com)
  • mechanism
  • This key role of the Per2-mediated phase alteration of p21 provides what we believe to be a novel mechanism in understanding cell cycle progression, its plasticity and its resistance to interference. (biomedsearch.com)
  • In contrast, a 'Sizer' mechanism has been shown to operate in yeast: the transition to a given cell cycle phase (resp. (elifesciences.org)
  • In the last 10 years, several important advances have been made in unraveling the molecular mechanism(s) responsible for this 'size checkpoint,' which transmits cell size information to the cell cycle control machinery. (elifesciences.org)
  • However, the regulatory mechanism of USP12 in human cervical carcinoma HeLa cell growth is unknown. (sigmaaldrich.com)
  • transcriptional
  • These data establish DREF as a global regulator of transcriptional programs that mediate cell proliferation and organ growth during animal development. (nih.gov)
  • TEF3-1 (transcriptional enhancer factor 3 isoform 1), also known as TEAD4 (TEA domain family member 4), belongs to a class of transcription factors, which are all widely expressed in eukaryotic cells. (pubmedcentralcanada.ca)
  • Phenotype
  • In addition, the mice lack NK cells, develop splenomegaly, and have T cells with an activated phenotype, phenotypes seen in IL-2 receptor beta chain-deficient mice. (nih.gov)
  • mammary epithelial
  • Of interest, the proliferation pattern of normal human mammary epithelial cells was much less affected by THC. (aacrjournals.org)
  • Human mammary epithelial cells (HMEC) were kindly given by Dr. Lacal (Instituto de Investigaciones Biomédicas, CSIC, Madrid, Spain) and grown in mammary epithelial growth medium (Cambrex, East Rutherford, NJ) according to the manufacturer's instructions. (aacrjournals.org)
  • control
  • Here, we identify PHD1 as a critical molecular link between oxygen sensing and cell-cycle control. (sigmaaldrich.com)
  • It has been proposed that cannabinoids are involved in the control of cell fate. (aacrjournals.org)
  • Engagement of these receptors by THC or endocannabinoids affects several signaling pathways, some of them directly involved in the control of cell fate. (aacrjournals.org)
  • phase
  • There is a restriction point between the G1 and S phases that must be overcome by mitogenic promoters to have the cell progress to S phase. (physiology.org)
  • unclear
  • However, it remains unclear how cells accommodate the dynamics and interplay between the Ras-ERK and PI3K-Akt pathways to regulate cell-fate decisions, mainly because of the lack of good tools to visualize ERK and Akt activities simultaneously in live cells. (go.jp)