• Extracts prepared from Trametes versicolor under the trade name of I'm-Yunity exhibit anti-tumorigenic activities, as supported by inhibition of the proliferation and induction of apoptosis in malignant cells. (spandidos-publications.com)
  • Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma. (nih.gov)
  • Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non-small cell lung cancer cells via p53-p21 signaling pathway. (nih.gov)
  • Downregulation of CDCA5 Can Inhibit Cell Proliferation, Migration, and Invasion, and Induce Apoptosis of Prostate Cancer Cells. (nih.gov)
  • If a cell has an error in its DNA that cannot be repaired, it may undergo self-destruction ( apoptosis ). (medlineplus.gov)
  • Apoptosis is a common process throughout life that helps the body get rid of cells that no longer work or that it doesn't need. (medlineplus.gov)
  • Apoptosis protects the body by removing genetically damaged cells that could lead to cancer, and it plays an important role in the development of the embryo and the maintenance of adult tissues. (medlineplus.gov)
  • p53 is a transcription factor that participates in cell cycle checkpoint processes and apoptosis. (lu.se)
  • Any process that modulates the rate or extent of progress through the mitotic cell cycle. (ntu.edu.sg)
  • The damaged cells did not successfully enter M phase nor were they stably blocked at G2 phase but underwent mitotic skipping and entered G1 phase as tetraploid cells, ultimately leading to senescence in G1. (bvsalud.org)
  • During cell growth and proliferation, ubiquitin plays an outsized role in promoting progression through the cell cycle. (intechopen.com)
  • Progression through the cell cycle is driven by the oscillating activity of Cyclin Dependent Kinases (CDKs). (intechopen.com)
  • We found that ParA:ParB ratios fluctuate between predation stages, their balance being critical for cell cycle progression. (jic.ac.uk)
  • Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. (yeastrc.org)
  • During cell cycle progression the centrosome undergoes a series of major structural and functional transitions that are regulated in part by phosphorylation. (le.ac.uk)
  • Our results demonstrate that mammalian Ecd plays a role in cell cycle progression via the Rb-E2F pathway. (unmc.edu)
  • Our data demonstrate that RUNX1/ETO maintains leukemia by promoting cell cycle progression and identifies G1 CCND-CDK complexes as promising therapeutic targets for treatment of RUNX1/ETO-driven AML. (prinsesmaximacentrum.nl)
  • Conclusion: p63, p16, MIB, Cal A, Cys A are markedly expressed and p16 is strongly suppressed in oral cavity tumors, which suggests that the latter protein may play a role in negative regulation of cell cycle progression. (bvsalud.org)
  • The notion could be that unique cellular mechanisms are triggered in the breast cancer cells to stimulate BRCA2 gene expression as a temporary measure to regulate the growth of the breast cancer cells. (biomedcentral.com)
  • While BRCA2 expression is involved in cell cycle checkpoints and DNA repair, the mechanisms of cell cycle-dependent regulation of BRCA2 gene expression remains elusive. (biomedcentral.com)
  • The aims of this thesis have been to investigate the regulation and function of the centrosomal kinase Nek2, which has previously been implicated in regulating centrosome cohesion at G2/M. Nck2 kinase activity is regulated by a number of mechanisms, including autophosphorylation and interaction with protein phosphatase 1. (le.ac.uk)
  • To determine whether the potentiating effect of extracellular ATP involves cell cycle control mechanisms, we have measured the expression of cyclins that are induced in different phases of the cell cycle in primary cultures of rat cortical astrocytes. (sagepub.com)
  • Cell Biochemistry & Function publishes original research articles and reviews on the mechanisms whereby molecular and biochemical processes control cellular activity with a particular emphasis on the integration of molecular and cell biology, biochemistry and physiology in the regulation of tissue function in health and disease . (wiley.com)
  • The mechanisms by which overgrowth primes cells to withdraw from the cell cycle remain unknown. (bvsalud.org)
  • Objective: To investigate the fate and underlying mechanisms of G2 phase arrest in cancer cells elicited by ionizing radiation (IR). (bvsalud.org)
  • Molecular mechanisms for regulation of gene expression at different levels: remodeling of chromatin, initiation of transcription, nuclear transport and signalling, and RNA interference. (lu.se)
  • Mechanisms for maintaining genetic information during cell division and the generation of genetic variation: replication, mitosis, meiosis, recombination. (lu.se)
  • Mechanisms that regulate development from single cell to multicellular organisms. (lu.se)
  • A striking decrease in Skp2 mRNA and protein expression and reciprocal increase in p27 protein level were observed in three PA-treated prostate cancer cells. (iiarjournals.org)
  • While studying the activity of BRCA2 gene promoter in breast cancer cells, we discovered that this promoter has bi-directional activity and the product of the reverse activity (a ZAR1-like protein, we named ZAR2) silences the forward promoter at the G0/G1 phase of the cell. (biomedcentral.com)
  • Standard techniques like cell synchronization by serum starvation, flow cytometry, N-terminal or C-terminal FLAG epitope-tagged protein expression, immunofluorescence confocal microscopy, dual luciferase assay for promoter evaluation, and chromatin immunoprecipitation assay were employed during this study. (biomedcentral.com)
  • Consistent with this hypothesis, we discovered a protein Rif1 that enters the nucleus right after mitosis and its knockout has a profound disruptive effect on RT in both mouse and human cells. (fsu.edu)
  • The Ecdysoneless (Ecd) protein is required for cell-autonomous roles in development and oogenesis in Drosophila, but the function of its evolutionarily conserved mammalian orthologs is not clear. (unmc.edu)
  • This gene encodes a nuclear protein which is involved in cell-cycle regulation. (nih.gov)
  • The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. (nih.gov)
  • The TSC2 gene encodes for the protein Tuberin, a tumour suppressor protein well known for it's ability to regulated cell growth and the cell cycle. (uwindsor.ca)
  • Having a better understanding of how specific changes in this large protein alters fundamental cell biology such as cell proliferation and cell size can ultimately help to effectively treat patients with these specific mutations. (uwindsor.ca)
  • OBJECTIVE: To study the effects of benzo(a)pyrene (BaP) on the cell cycle distribution and activities of mitogen-activated protein kinase (MAPK) signal molecules (ERK1/2, JNK1/2 and p38) in human embryo lung cells (HELF), and to investigate the relationship between alterations of MAPK protein phosphorylation and the cell cycle distributions. (uky.edu)
  • METHODS: The phosphorylation of MAPK were induced by exposing HELF cells to BaP at 0.1, 0.5, 2.5 and 12.5 micromol/L. The phosphorylation and protein expression levels of ERK1/2, JNK1/2 and p38 were determined through western-blotting assay. (uky.edu)
  • The protein product of the murine double minute gene 2 (mdm-2) plays a central role in the regulation of p53. (lu.se)
  • protein sorting and protein maturation by passage through the cytoplasmic organelles of the cell. (lu.se)
  • The most useful tests to diagnose hepatitis include laboratory evaluation of urine bilirubin and urobilinogen, total and direct serum bilirubin, alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST), alkaline phosphatase (ALP), prothrombin time (PT), total protein, albumin, complete blood cell (CBC) count, and in severe cases, serum ammonia. (medscape.com)
  • Choline kinase alpha (ChoKalpha) is an enzyme involved in the metabolism of phospholipids recently found to play a relevant role in the regulation of cell proliferation, oncogenic transformation and human carcinogenesis. (nih.gov)
  • The molecular basis to understand the connection between phospholipids metabolism and cell cycle regulation through choline kinase is reported. (nih.gov)
  • Genetic alteration of glucuronide metabolism by altered expression of a Pisum sativum UDP-glucuronosyltransferase (PsUGT1) results in an altered cell cycle in pea, alfalfa, and Arabidopsis. (arizona.edu)
  • Building on the newer pathways for pathogenesis includes the E3 ubiquitin ligase Peli1 as an important regulator of T-cell metabolism and antitumor immunity. (medscape.com)
  • Hence, Peli1 is regarded as a novel regulator of mTORC1 and downstream mTORC1-mediated actions on T-cell metabolism and antitumor activity. (medscape.com)
  • The eukaryotic cell cycle requires precise temporal coordination of the activities of hundreds of 'executor' proteins (EPs) involved in cell growth and division. (nih.gov)
  • The project uses a mouse model, human cells, and patient samples to determine whether Spy1 and related proteins provide a signature to identify triple negative breast cancer patients who will respond to specific treatments. (wesparkhealth.com)
  • The ultimate goals of our studies are to understand how these proteins enable accurate chromosome segregation and to discover how they are coordinated with each other and with other aspects of cell physiology. (nih.gov)
  • Rap 1 is a member of a group of proteins involved in the regulation of cell proliferation and differentiation. (medscape.com)
  • Several common birth defects, such as Down's syndrome, result from aneuploidy arising during meiotic cell divisions. (nih.gov)
  • Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. (planteome.org)
  • Link to all annotated objects annotated to negative regulation of meiotic cell cycle process involved in oocyte maturation. (planteome.org)
  • 7) Human shugoshin 2 (Sgo2), a protector of meiotic cohesin with hitherto unknown function in somatic cells, represents a crucial second branch of anaphase regulation. (uni-bayreuth.de)
  • Three chemical inhibitors of MAPK (AG126, SP600125 and SB203580) could significantly inhibit the cell cycle alteration because of BaP treatment. (uky.edu)
  • [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
  • In comparison, the other available flu antiviral medications, which are "neuraminidase inhibitors," do not directly interrupt replication within an infected cell, but instead work to prevent new copies of the virus from leaving the infected cell and spreading to healthy cells. (cdc.gov)
  • We address this question using CDK4/6 inhibitors, which arrest cells in G0/G1 and are licensed to treat advanced HR+/HER2- breast cancer. (bvsalud.org)
  • Replication Timing (RT) is a stable epigenetic property that is cell type specific and is extensively regulated during differentiation in units that range from 400-800kb called replication domains. (fsu.edu)
  • But the dynamics of this relationship during differentiation and cell cycle have been poorly understood. (fsu.edu)
  • After fertilization, blastomeres of the newly created embryo undergo global epigenetic changes and simultaneously initiate transcription from the zygotic genome and differentiation forming separate cell lineages. (ehu.eus)
  • In recent years, interest in the possible molecular regulators of cell proliferation and differentiation in a wide range of regeneration models has grown significantly, but the cell kinetics of this process remain largely a mystery. (mdpi.com)
  • This includes the analysis of genes in germline stem cell proliferation and differentiation. (ncl.ac.uk)
  • The Draviam lab aims to understand the molecular principles that govern cell division and the consequence of its failure when cells transition between states during differentiation. (qmul.ac.uk)
  • Together with MSD, the project aims to focus on developing AI methods to track iPSC (induced Pluripotent Stem Cells) differentiation to neural precursors, astrocytes and neurons. (qmul.ac.uk)
  • During the process of differentiation, quiescence and senescence are two cell dormancy states with distinct cell fates and transcriptomic statuses. (qmul.ac.uk)
  • The eukaryotic cell cycle is such a case, being governed by waves of cyclin-dependent kinase (cyclin/Cdk) activities that rise and fall with specific timing and guarantee its timely occurrence. (vu.nl)
  • Moreover, the parS chromosomal context in non-replicative cells, combined with ParB depletion at cell division, critically contribute to the unique cell cycle-dependent organization of the centromere in this bacterium, highlighting new levels of complexity in chromosome segregation and cell cycle control. (jic.ac.uk)
  • In this review, we discuss some aspects of early embryonic development in mammals, namely the fidelity of chromosome segregation and occurrence of aneuploidy, as well as the clinical applications of cell cycle monitoring in human embryos. (ehu.eus)
  • This animation provides an overview of the androgen receptor (AR) signaling pathway and its interaction with cell cycle regulation. (lillymedical.com)
  • This infographic provides an overview of the androgen receptor (AR) signaling pathway and the rationale to target the cell cycle in advanced prostate cancer. (lillymedical.com)
  • These findings suggest that signaling by P2Y receptors, most likely of the purine/pyrimidine subtype, enhance the ability of FGF2 to stimulate entry into a new cell cycle, as well as DNA replication, by an ERK-dependent mechanism, whereas signaling by P2X receptors, possibly the P2X7 subtype, inhibits FGF2-induced mitogenesis in astrocytes. (sagepub.com)
  • FRT T cell subset fluctuations were discovered that synchronized to cycle-driven CCR5 signaling. (cdc.gov)
  • Identification of UHRF2 as a Negative Regulator of Epithelial-Mesenchymal Transition and Its Clinical Significance in Esophageal Squamous Cell Carcinoma. (nih.gov)
  • risk of esophageal squamous cell carcinoma. (who.int)
  • PMID:18786442 mutations and the risk of esophageal squamous cell carcinoma. (who.int)
  • Hirt, H & Heberle-Bors, E 1994, ' Cell cycle regulation in higher plants ', Seminars in Developmental Biology , vol. 5, no. 3, pp. 147-154. (edu.sa)
  • Gene regulation in developmental biology and the cell cycle. (lu.se)
  • Due to their affiliation with DNA, histones are important for successful cell replication, which takes place via the cell cycle. (news-medical.net)
  • Histones can be classified as replication dependent or replication independent, which is decided by their expression pattern during the cell cycle. (news-medical.net)
  • The replication independent histone genes are transcribed at a relatively constant low rate, regardless of cell cycle stage. (news-medical.net)
  • However, most of the vertebrate histone genes are replication dependent and are therefore more highly expressed during the cell cycle's S phase. (news-medical.net)
  • Lastly, we explored the conservation of replication timing at single cell level that revealed a highly conserved yet stochastic regulation of replication timing. (fsu.edu)
  • This is consistent with a model of replication timing regulation where the timing is the outcome of stochastic origin firing and is not affected by the precise environment within a cell. (fsu.edu)
  • In summary, the work descried in this thesis uncovers a model where replication-timing is regulated at the unit of chromatin structure called TADs, which are generally stable across cell-types, but the compartment that they reside in corresponds to the time of their replication. (fsu.edu)
  • Interphase chromatin structure is established along with the establishment of RT and may act as scaffold for replication regulation factors like Rif1. (fsu.edu)
  • We found that ATP potentiated the ability of FGF2 to stimulate expression of cyclin D1, a regulator of cell cycle entry, as well as cyclin A, a regulator of DNA replication. (sagepub.com)
  • Overgrown cells experience replication stress, resulting in a second p21 wave that promotes cell cycle withdrawal from G2 or the subsequent G1. (bvsalud.org)
  • In particular, ubiquitin-mediated degradation is critically important at transition points where it provides directionality and irreversibility to the cell cycle, which is essential for maintaining genome integrity. (intechopen.com)
  • Importantly, we are inserting the Tuberin-C698Y mutation into the HEK293 cells genome through the CRISPR-Cas9 system to determine the endogenous significance of this specific change. (uwindsor.ca)
  • studies on cell cycle regulation and genome instability. (ncl.ac.uk)
  • The National Human Genome Research Institute's Talking Glossary provides information about the cell cycle . (medlineplus.gov)
  • The overarching goal of this proposal is to elucidate the pro-survival role of hic-5 following podocyte injury by studying its effect on cell cycle checkpoint control. (grantome.com)
  • We propose that Clb3-mediated coordination of cyclin/Cdk waves reconciles checkpoint and oscillatory cell cycle models. (vu.nl)
  • The course is an optional second-cycle course for a degree of Bachelor or Master of Science in Biology and Molecular Biology. (lu.se)
  • Our results show that the Tuberin/CycB1 interaction regulates cell size and this regulation is nutrient dependent. (uwindsor.ca)
  • The cell cycle has checkpoints (also called restriction points), which allow certain genes to check for problems and halt the cycle for repairs if something goes wrong. (medlineplus.gov)
  • Elucidation of the mechanism of this association will not only allow us to test the importance of RanBP2 complex formation in a non-vertebrate system, but also provide a convenient alternative mechanism for formation of this complex that can be used to understand its importance in vertebrate cells. (nih.gov)
  • The primary remit of the journal is on mammalian biology both in vivo and in vitro but studies on the biochemistry and function of cells in situ are especially encouraged . (wiley.com)
  • After being promoted to Senior Investigator, he moved to Singapore where he worked at the Institute of Molecular Cell Biology (IMCB/A*STAR/National University of Singapore). (lu.se)
  • Using differential microarray analysis, we identify target genes that provide the basis for the understanding of the molecular mechanism for the regulation of cell proliferation and transformation mediated by over-expression of the human ChoKalpha. (nih.gov)
  • The regulation of transcription of histone genes differs between eukaryotes. (news-medical.net)
  • Therefore, NPAT could be the link between cell cycle machinery and shared heightened transcription of histone genes during S phase. (news-medical.net)
  • The isolation of plant genes homologous to cdk and cyclin components from yeast and animals proves the existence of a basic cell cycle machinery in all eukaryotes. (edu.sa)
  • How do genes control the growth and division of cells? (medlineplus.gov)
  • A variety of genes are involved in the control of cell growth and division. (medlineplus.gov)
  • The results indicate that TCE induces changes in expression of certain important cell cycle regulation genes. (cdc.gov)
  • Gene pathway analysis by RNA sequencing identified T(MM)-specific enrichment of genes involved in hormonal regulation and inflammatory responses. (cdc.gov)
  • A re-evaluation of parameters of cell kinetics in view of our increasing knowledge of the molecular pathways of cell cycle control may provide more prognostic information for the management of patients with malignant lymphomas. (bmj.com)
  • The working group of the Histiocyte Society divided histocytic disorders into three groups: (1) dendritic cell histiocytosis, (2) macrophage-related disorders, and (3) malignant histiocytosis. (medscape.com)
  • During interphase, chromosomes are enclosed within nuclei, and exchange of all molecules between this compartment and the rest of the cell occurs through nuclear pore complexes (NPCs). (nih.gov)
  • Tight regulation of this process ensures that a dividing cell's DNA is copied properly, any errors in the DNA are repaired, and each daughter cell receives a full set of chromosomes. (medlineplus.gov)
  • Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
  • Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)
  • Entry into the S phase in animal cells is regulated to a large extent by the cyclin E-CDK2 kinase complex. (news-medical.net)
  • cdk and cyclin expression has been shown to be involved in the spatial and temporal control of cell division in a variety of developmental processes. (edu.sa)
  • Furthermore, studies on cdk and cyclin expression not only correlate with actual cell cycle activity but also with cell division competence providing a working model to understand regeneration capacity at the molecular level. (edu.sa)
  • Disruption of cyclin/Cdk oscillations could result in dysfunction through reduced cell division. (vu.nl)
  • Here we show that a minimal yeast cell cycle network is able to oscillate autonomously, and that cyclin/Cdk-mediated positive feedback loops (PFLs) and Clb3-centered regulations sustain cyclin/Cdk oscillations, in known and hypothetical network designs. (vu.nl)
  • BACKGROUND/AIM: P21 is a cyclin-dependent kinase inhibitor regulating the cell cycle as a tumor suppressor. (bvsalud.org)
  • A highly-conserved cyclin-dependent kinase that activates other CYCLIN DEPENDENT KINASES and plays a key role in regulation of the CELL CYCLE. (bvsalud.org)
  • Experiments in human cell lines, mice, Drosophila, and Caenorhabditis elegans have shown that endonuclease G (ENDOG) plays a protective role against the development of TSC. (medscape.com)
  • Philipp was trained as a hard-core biochemist and in his own lab uses extensively genetically modified mice to study cell cycle regulation and human disease. (lu.se)
  • Numerous E3 ubiquitin ligases, which facilitate the ubiquitination of specific substrates, have been shown to control G1/S. In this chapter, we will discuss components in the ubiquitin proteasome system that are implicated in G1/S control, how these enzymes are interconnected, gaps in our current knowledge, and the potential role of these pathways in the cancer cycle and disease proliferation. (intechopen.com)
  • Understanding the role of hic-5 in preventing podocyte loss by regulating the podocyte cell cycle may guide our efforts to discover pathways to nephron loss, identify prognostic biomarkers and develop targeted podocyte-specific therapies for proteinuric kidney diseases. (grantome.com)
  • These findings elaborate on the regulation of mTORC1 during energetic stress and interactions between prosurvival and prodeath pathways. (medscape.com)
  • Role of mammalian Ecdysoneless in cell cycle regulation. (unmc.edu)
  • To study the cellular function of Ecd in mammalian cells, we generated Ecd(lox/lox) mouse embryonic fibroblast cells from Ecd floxed mouse embryos. (unmc.edu)
  • We research human embryonic stem (ES) cells, germline stem cells and somatic stem cells. (ncl.ac.uk)
  • Most of the tumors represent hamartomas and, in many organs, resemble embryonic cells, suggesting that the defect occurs at an early stage in life. (medscape.com)
  • A growing body of research shows that human papillomavirus (HPV) is a common and increasing cause of oropharyngeal squamous cell carcinoma (OSCC). (cdc.gov)
  • We focus on the role of HPV in the increased incidence of oropharyngeal squamous cell carcinoma (OSCC), the head and neck cancer in which HPV is most commonly found ( 4 ). (cdc.gov)
  • Head and neck cancer most commonly is of the squamous cell carcinoma type (HNSCC) and includes cancers of the oral cavity, oropharynx, hypopharynx, larynx, sinonasal tract, and nasopharynx. (cdc.gov)
  • Arbyn M, Bergeron C, Klinkhamer P, Martin-Hirsch squamous cell carcinoma in a high-risk region in Iran. (who.int)
  • Methods: fifteen histological specimens of spindle cell squamous cell carcinoma of the lower lip were obtained from the Department of Oral Pathology, Bahia Federal University. (bvsalud.org)
  • The signal-transduction properties of FFLs allow one (or a few) Cdk signal(s) to drive a host of cell cycle responses in correct temporal sequence. (nih.gov)
  • Under stress, microglial cells are induced into the M1 type, releasing inflammatory factors and causing neuroinflammatory responses. (frontiersin.org)
  • In a repetitive low-dose vaginal challenge model, productive SHIV(163P3) infection only occurred during intervals of mounting type-1 T cell responses (n=5/5). (cdc.gov)
  • Finally, we identify similar type-1 inflammatory T cell responses over the menstrual cycle are occurring in healthy women. (cdc.gov)
  • Notably, the G1/S boundary represents a major barrier to cell proliferation and is universally dysfunctional in cancer cells, allowing for the unbridled proliferation observed in malignancy. (intechopen.com)
  • We have demonstrated that phenylacetate(PA)-induced cell cycle arrest in human prostate cancer is mediated by increase of p27. (iiarjournals.org)
  • In this study, we further investigated the mechanism of PA-induced p27 expression in prostate cancer cells (LNCaP, androgen-independent LNCaP [AIDL] and PC-3). (iiarjournals.org)
  • In vitro ubiquitination assay showed a decreased p27 ubquitination in PA-treated prostate cancer cells. (iiarjournals.org)
  • Our results suggest that PA attenuated Skp2 expression, thereby inhibiting ubiquitination and promoting p27 accumulation in all three prostate cancer cell lines. (iiarjournals.org)
  • Novel Cell Cycle Regulation in the Initiation and Therapeutic Intervention of Triple Negative Breast Cancer. (wesparkhealth.com)
  • This slide deck examines the unmet need in advanced prostate cancer, the AR pathway, its interaction with cell cycle regulation, and novel approaches to enhance AR-targeting. (lillymedical.com)
  • AR, the cell cycle, and prostate cancer. (lillymedical.com)
  • Cancer cell , 34 (4), 626-642.e8. (prinsesmaximacentrum.nl)
  • Disruption of normal regulation of the cell cycle can lead to diseases such as cancer. (medlineplus.gov)
  • On the other hand, the infiltration of organs by a monoclonal population of aberrant cells, the possibility of lethal evolution, and the cancer-based modalities of successful treatment are all consistent with a neoplastic process. (medscape.com)
  • Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer. (lu.se)
  • Cell Biochemistry and Function currently does not publish research in specific areas that are better served by specialist journals. (wiley.com)
  • Cell Biochemistry & Function also discourages submission of research based exclusively on analysis of publically available transcriptomic and proteomic datasets, although the acceptability of specific manuscripts in this particular area can be discussed with the Editor-in-Chief. (wiley.com)
  • However, the mechanism by which this enzyme is involved in the regulation of these processes is not yet understood. (nih.gov)
  • BACKGROUND: The menstrual cycle influences HIV infection-risk in women, although the timing and underlying mechanism are unclear. (cdc.gov)
  • It is our hypothesis that these mutations can affect the Tuberin/CycB1 interaction and result in dysregulation of cell proliferation and cell size. (uwindsor.ca)
  • [ 3 ] Taken together, these findings have led some to speculate that LCH is not a specific disease of epidermal Langerhans cells, but rather one of mononuclear phagocyte dysregulation. (medscape.com)
  • The presence of neurotransmitter receptors in microglia illustrates their functional connection to neurons and this receptor activation could cause microglial cells to perform different activation phenotypes ( Pocock and Kettenmann, 2007 ). (frontiersin.org)
  • By assaying their anti-proliferative and anti-apoptotic effects using human promyelocytic HL-60 cells, we found that the ethanolic extract of I'm-Yunity-Too was more active in inducing cell death compared to I'm-Yunity, based on measured changes in the expression of caspase 3 and Bax. (spandidos-publications.com)
  • Methods: Human melanoma A375 and 92-1 cells were treated with X-rays radiation or Aurora A inhibitor MLN8237 (MLN) and/or p21 depletion by small interfering RNA (siRNA). (bvsalud.org)
  • CDK4/6 inhibitor washout results in some cells entering S-phase. (bvsalud.org)
  • The mutations of BRCA2 gene predispose the cells towards neoplastic development. (biomedcentral.com)
  • Specifically, a variety of other cellular populations have been identified that possess phenotypic characteristics similar to Langerhans cells, including expression of CD207 and Birbeck granules. (medscape.com)
  • Despite their importance for immunity against sexually transmitted infections (STIs), the composition of female reproductive tract (FRT) memory T cell populations in response to changes within the local tissue environment under the regulation of the menstrual cycle remains poorly defined. (cdc.gov)
  • Peripheral blood mononuclear cell (PBMC) samples from healthy women (n=10) were prospectively collected over the course of a menstrual cycle to profile T cell populations. (cdc.gov)
  • Simultaneous activity of both enzymes only occurs when cells rush through mitosis due to pathological loss of the SAC. (uni-bayreuth.de)
  • Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)
  • Here, we show that in humans and pig-tailed macaques, the cycle determines distinct CD4 T cell surveillance behaviors by subsets corresponding to migratory memory (T(MM)) and resident memory (T(RM)) cells. (cdc.gov)
  • In plants, cell division and development are closely interlinked processes that are regulated by phytohormones. (edu.sa)