Loading...
  • induces
  • Prolonged p21 up-regulation induces a senescent phenotype in normal and cancer cells, accompanied by an increase in intracellular reactive oxygen species (ROS). (biomedsearch.com)
  • complexes
  • The authors report a mathematical model of the G1 to S network that newly takes into account nucleo/cytoplasmic localization, the role of the cyclin-dependent kinase Sic1 in facilitating nuclear import of its cognate Cdk1-Clb5, Whi5 control, and carbon source regulation of Sic1 and Sic1- containing complexes. (cellml.org)
  • WAF1
  • Białko p21 (WAF1) jest w stanie oddziaływać z jądrowym antygenem komórek proliferujących ( proliferating cell nuclear antigen − PCNA), czynnikiem dodatkowym polimerazy DNA , i tym samym odgrywać rolę regulatora zarówno przy replikacji materiału genetycznego w fazie S jak i przy naprawie łańcucha . (wikipedia.org)
  • proteins
  • To facilitate purification of AID-interacting proteins, we used a tagged AID derivative fused at its N terminus to two tandem protein G domains followed by a FLAG3 peptide, with the two protein G domains separated from the FLAG3 peptide by a cleavage site for TEV protease ( Fig. 1 A ). Most AID in B cells is normally found in the cytoplasm. (rupress.org)
  • Ras proteins in the control of the cell cycle and cell differentiation. (embl.de)
  • antigen
  • Histopathology and immunohistochemistry for proliferative cell nuclear antigen, cyclin D1, and apoptotic indices were done in the prostatic lesions, including invasive adenocarcinomas, intraepithelial neoplasms, and nonlesional glands. (aacrjournals.org)
  • The proliferative cell nuclear antigen- and cyclin D1-positive indices in adenocarcinomas, prostatic intraepithelial neoplasm, and nonlesional glands in rats treated with DMAB and silymarin were slightly lower than that of the DMAB-alone group. (aacrjournals.org)
  • induction
  • METHODS: WJCs subjected to adipocyte induction were observed changes in the cell morphology and alterations in actin filament formation. (biomedsearch.com)
  • Induction of p53 and cyclin-dependent kinase inhibitors such as p15INK4b, p16INK4a, p19ARF, and p21WAF1 accounts for this response. (embl.de)
  • Although ESC have unlimited capacity for self-renewal and powerful pluripotency to differentiate into any type of cells in the human body theoretically, immune-rejection, teratoma formation, induction uncertainty and ethical concerns have hampered their progress towards any clinical applications. (medsci.org)
  • neuronal
  • It has been reported that there existed increasing number of immature neuronal cells in the brains of patients with AD, compared with the brains of age-matched control subjects [ 7 ]. (hindawi.com)
  • Although the underlying mechanism(s) is presently unknown, a candidate peptide fragment (AChE-peptide) has recently been identified, and been shown to induce a continuum of apoptotic and necrotic neuronal cell death in rat hippocampal organotypic cultures. (springer.com)
  • proliferative
  • Unlike other species, human corneal endothelial cells (HCEC) are notorious for their limited proliferative capacity in vivo [ 4 ] due the mitotic block at the G1 phase in the cell cycle [ 5 ]. (medsci.org)
  • endothelial cells
  • Corneal endothelial cells play a critical role in maintaining corneal transparency and dysfunction of these cells caused by aging, diseases (such as Fuch's dystrophy), injury or surgical trauma, which can lead to corneal edema and blindness. (medsci.org)
  • In this review, we summarize the recent advances in reprogramming adult human corneal endothelial cells into their progenitor status, the expansion methods and characteristics of human corneal endothelial progenitors, and their potential clinical applications as corneal endothelial cell grafts. (medsci.org)
  • The endothelial cells originate from cranial neural crest cells, forming a single monolayer of hexagonal cells lining the Descemet's membrane of the posterior cornea [ 1 ], and play a critical role in mediating vision function [ 2 ]. (medsci.org)
  • ovarian carcinomas
  • The promoter methylation statuses of 40 genes in primary ovarian carcinomas including 47 clear- and 63 non-clear-cell type tissues, 6 OCCA cell lines, 29 benign ovarian endometriotic cysts, and 31 normal controls were analyzed by methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA). (springermedizin.de)
  • The purpose of this study was to evaluate the subcellular localization of this cyclin-dependent kinase inhibitor in a large cohort of primary ovarian carcinomas and compare the results with clinicopathologic variables and overall survival. (aacrjournals.org)
  • correlation
  • Hokari S., Hasegawa M., Sakagishi Y., Kikuchi G. Deoxyuridine triphosphate nucleotidohydrolase activity and its correlation with multiplication of erythroid cells in rat spleen. (springer.com)
  • mice
  • Utilizing transgenic knockout and overexpressing mice his laboratory is involved in demonstrating the patterns of CD4+ T cell trafficking through lymph nodes and lung parenchymal in normal and immunologically challenged lungs and identifying potential therapeutic implications of altering recruitment patterns of Regulatory T cells. (bu.edu)
  • Targeting cyclins and cyclin-dependent kinases in cancer: lessons from mice, hopes for therapeutic applications in human. (thefreedictionary.com)
  • Synthesis
  • It is divided into four phases: G1, S, G2, and M. Passage through the cell cycle is strictly regulated by a molecular interaction network, which involves the periodic synthesis and destruction of cyclins that bind and activate cyclindependent kinases that are present in nonlimiting amounts. (cellml.org)
  • Simvastatin, an HMG-CoA reductase inhibitor, which decreases cholesterol synthesis by inhibiting mevalonate pathways and is widely used to treat cardiovascular diseases. (pubmedcentralcanada.ca)
  • ethanol
  • Cells were cultured with or without ethanol, lacking or containing the antioxidants N -acetylcysteine (NAC) or trolox, for three days. (mdpi.com)
  • Although reactive oxygen species are thought to have a significant role in ethanol-induced hepatocellular damage, they may have a less important role in the inability of hepatocytes to replace dead or damaged cells. (mdpi.com)
  • cellular
  • For example, application to malignant cells of the "histone code" hypothesis, which posits that different combinations of histone modifications mediate unique cellular responses, suggests that abnormal histone modifications in cancers serve as one of the molecular switches for malignant transformation. (aacrjournals.org)
  • Therefore, stem cell research will be a major driver in the search for an AD cellular therapy. (hindawi.com)
  • Using specific antagonists, it was possible to track a series of cellular events following application of 1 nM AChE-peptide: NMDA receptor activation, opening of the L-type voltage gated calcium channel, activation of calcium/calmodulin kinase II, generation of reactive oxygen species and caspase activation. (springer.com)
  • encoding gene
  • The cortactin oncoprotein is frequently overexpressed in head and neck squamous cell carcinoma (HNSCC), often due to amplification of the encoding gene (CTTN). (garvan.org.au)
  • Differentiation
  • In this review, we will discuss the current knowledge of adult corneal endothelial stem cells or progenitors with limited differentiation potential, the engineering of such HCEC grafts, and the potential application of HCEC tissue engineering. (medsci.org)
  • OC differentiation and function are also controlled by cell surface receptors, including MDL-1, TREM2, and OSCAR, which transmit intracellular signals through associated transmembrane adaptors containing ITAMs ( 4 - 11 ). (jimmunol.org)
  • Cancer
  • Cyclacel is a biopharmaceutical pioneer developing small molecule drugs that target various phases of cell cycle control for the treatment of cancer and other serious diseases, particularly those of high unmet medical need. (cyclacel.com)
  • The aim of this study was to investigate whether EMT correlates with CD24+CD44+ and CD133+ cells in pancreatic cancer. (biomedsearch.com)
  • Cell-cycle regulation is a hallmark of many biological activities that encompass physiological processes, such as development, and pathophysiological processes, such as cancer and wound healing. (arvojournals.org)
  • Epigenetic alterations are thought to be important factors for determining the characteristics of various cancer cells. (aacrjournals.org)
  • Some of the non-biological drugs, known as Cyclin-dependent kinase (CDK) inhibitors, are currently being tested for use in cancer treatment. (thefreedictionary.com)
  • In breast cancer, the appearance of p27 kip in the cytoplasm of tumor cells is associated with poor prognosis (3, 7) . (aacrjournals.org)
  • therapeutic
  • This study is to analyze promoter methylation of various tumor suppressor genes in different types of ovarian carcinoma and to identify potential therapeutic targets of ovarian clear cell adenocarcinoma (OCCA). (springermedizin.de)
  • human
  • PGA13 encodes a GPI protein in the human pathogen Candida albicans, which is highly up-regulated during cell wall regeneration in protoplasts. (biomedsearch.com)
  • 7 8 9 The Ser-10 site is also phosphorylated by human kinase-interacting stathmin (hKIS), 10 a nuclear serine-threonine kinase. (arvojournals.org)
  • Silymarin and silibinin, which is the major active constituent of silymarin, can inhibit the growth of human prostate carcinoma LNCaP, PC-3, and DU145 cells in culture ( 15 - 17 ). (aacrjournals.org)
  • role
  • The fungal cell wall is an essential organelle required for maintaining cell integrity and also plays an important role in the primary interactions between pathogenic fungi and their hosts. (biomedsearch.com)
  • Here we investigated the role of SGK1 in the regulation of cell motility. (biomedsearch.com)
  • Over the past several years, in collaboration with Bill Cruikshank, he has studied the role of IL-16 in recruitment and development of Regulatory T cells and demonstrated that it plays a key role in tolerance to airborne allergens. (bu.edu)
  • Parsels L. A., Chu E. The role of translational control of the cell cycle. (springer.com)
  • Chan J, Quik M (1993) A role for the nicotinic α-bungarotoxin receptor in neurite outgrowth in PC12 cells. (springer.com)
  • belong
  • Whereas OB are of mesenchymal origin, OC originate from hematopoietic stem cells and belong to the myeloid lineage. (jimmunol.org)
  • regulation
  • Rode W., Scanlon K.J., Moroson B.A., Bertino J.R. Regulation of thymidylate synthetase in mouse leukemia cells (L1210). (springer.com)
  • tumor cells
  • In conclusion, FTIs present a promising class of anticancer agents, acting through biochemical modulation of the tumor cells. (embl.de)
  • senescence
  • However, oncogenic cells bypass this process due to the lack of oncogene-induced senescence effectors, such as p16 or p53 ( 1 ), and establish malignant transformation. (aacrjournals.org)
  • Alzheimer's disease, one of the neurodegenerative diseases, shows the progressive senescence of neural progenitor/stem cells. (hindawi.com)
  • reactive oxygen
  • Anegawa NJ, Guttman RP, Grant ER, Lindstrom J, Lynch DR (2000) N -Methyl- d -aspartate receptor mediated toxicity in nonneuronal cell lines: characterisation using fluorescent measures of cell viability and reactive oxygen species. (springer.com)