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  • Mammalian
  • The G1 checkpoint, also known as the restriction point in mammalian cells and the start point in yeast, is the point at which the cell becomes committed to entering the cell cycle. (wikipedia.org)
  • University of Iowa Roy J. and Lucille A. Carver College of Medicine researchers in the UI Holden Comprehensive Cancer Center have been awarded a five-year, $1.5 million grant from the National Cancer Institute to investigate a new hypothesis about how the mammalian cell cycle is regulated. (uiowa.edu)
  • This light exposure causes increases in PER1 mRNA, suggesting that the PER1 gene plays an important role in entrainment of the mammalian biological clock to the light-dark cycle. (wikipedia.org)
  • activates
  • The decision to commit to a new round of cell division occurs when the cell activates cyclin-CDK-dependent transcription which promotes entry into S phase. (wikipedia.org)
  • CHK2
  • No. R1536 shows detection of a predominant band at ~60 kDa corresponding to phosphorylated CHK2 (arrowhead) in MCF-7 whole cell lysates after treatment with doxorubicin. (acris-antibodies.com)
  • Chk2 bearing the activating phosphorylation on threonine-68 accumulates in BRCA1 nuclear bodies when the cells arrest at the G2/M boundary. (uu.nl)
  • activate
  • Those complexes, in turn, activate different downstream targets to promote or prevent cell cycle progression. (wikipedia.org)
  • When cells are ready to divide, because cell size is big enough or because they receive the appropriate stimulus, they activate the mechanism to enter into the cell cycle, and they duplicate most organelles during S (synthesis) phase, including their centrosome. (wikipedia.org)
  • defects
  • In contrast, cancer cells with defects in redox-sensitive checkpoints will continue to proliferate,' explained Goswami, who also is a co-director of the Free Radical Research Core in the Holden Comprehensive Cancer Center at the UI. (uiowa.edu)
  • undergo
  • After a constant, organism-specific number of cleavages, many metazoan embryos undergo the mid-blastula transition (MBT), which initiates extensive cell cycle remodeling. (upenn.edu)
  • Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. (apexbt.com)