• Proteins involved in the ATM-and-Rad3-related kinase (ATR)-dependent S-phase checkpoint response (Chk1 and Rad17) were also phosphorylated but not ataxia telengectasia mutated kinase. (nih.gov)
  • In response to DNA damage, a synthetic lethal relationship exists between the cell cycle checkpoint kinase MK2 and the tumor suppressor p53. (nature.com)
  • G 2 /M arrest was associated with DNA damage as indicated by phosphorylation of H 2 A.X at Ser139 and activation of checkpoint kinase 2 (Chk2) in all the three cell lines. (aspetjournals.org)
  • You can find six phosphorylation sites in RSK1 that are crucial for its activation and its own subsequent part in substrate phosphorylation (21 22 Of the phosphorylation of Ser-380 can be very important to RSK1 activation traveling functions such as for example rules of gene manifestation and protein synthesis and cell cycle regulation as a downstream Nisoxetine hydrochloride kinase in the Mos-MAPK pathway (23). (biospraysehatalami.com)
  • DNA damage checkpoint response to accidental DSBs during mitosis requires the Rad53 effector kinase, whereas the meiosis-specific Mek1 kinase, together with Red1 and Hop1, mediates the recombination checkpoint in response to programmed meiotic DSBs. (unimi.it)
  • Role of the Saccharomyces cerevisiae Rad53 checkpoint kinase in signaling double-strand breaks during the meiotic cell cycle / H. Cartagena-Lirola, I. Guerini, N. Manfrini, G. Lucchini, M.P. Longhese. (unimi.it)
  • The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation. (expasy.org)
  • Glc7p functions in opposition to key spindle assembly checkpoint protein Aurora kinase (Ipl1p). (yeastgenome.org)
  • It also directly binds to BubR1, a kinetochore-associated kinase implicated in the mitotic checkpoint, the major cell cycle control pathway in which unattached kinetochores prevent anaphase onset. (rupress.org)
  • Thus, CENP-E is required for enhancing recruitment of its binding partner BubR1 to each unattached kinetochore and for stimulating BubR1 kinase activity, implicating it as an essential amplifier of a basal mitotic checkpoint signal. (rupress.org)
  • This makes kinase signaling particularly amenable to comparative studies, and kinase activity a particularly good readout of the physiological state of any cell. (wormbook.org)
  • Cyclin dependent-kinase 2 (CDK2) plays important functions during the mitotic cell cycle and also facilitates several key events during germ cell development. (lu.se)
  • The mitotic kinase monopolar spindle 1 (Mps1) is a key regulator of the Spindle assembly checkpoint, which ensures the correct chromosome segregation. (lu.se)
  • Therefore, compared to normal p53-proficient cells, p53-defective cells are more reliant on MK2 activity, which drives an alternative cell cycle checkpoint pathway that stabilizes the CKI inhibitors p27 Kip1 and Gadd45α in order to maintain G 1 /S and G 2 /M arrest after certain types of DNA damage 16 , 18 . (nature.com)
  • Weighed against its homologs Plk1 (and its own connected signaling pathway) offers attracted much interest because overexpression of Plk1 can be firmly correlated with carcinogenesis (10 11 Furthermore inhibition of Plk1 using RNA disturbance (RNAi) or particular little molecule inhibitors causes development arrest or apoptosis in tumor cells (12-14). (biospraysehatalami.com)
  • To determine the expression of tissue inhibitors of metalloproteinases (TIMP-2) in oral squamous cell carcinoma (OSCC) and the difference in its expression level between positive and negative HPV-16 (human papilloma virus- 16) OSCC patients. (bvsalud.org)
  • Immunotherapy with programmed cell death protein-1 (PD-1) inhibitors had previously shown efficacy as monotherapy in second- or later-line therapy for women with cervical cancer, but KEYNOTE 826 was the first study to show a benefit to promoting immunotherapy to the front ranks. (medscape.com)
  • Cell cycle checkpoints are control mechanisms in the eukaryotic cell cycle which ensure its proper progression. (wikipedia.org)
  • Each checkpoint serves as a potential termination point along the cell cycle, during which the conditions of the cell are assessed, with progression through the various phases of the cell cycle occurring only when favorable conditions are met. (wikipedia.org)
  • Progression through these checkpoints is largely determined by the activation of cyclin-dependent kinases by regulatory protein subunits called cyclins, different forms of which are produced at each stage of the cell cycle to control the specific events that occur therein. (wikipedia.org)
  • Those complexes, in turn, activate different downstream targets to promote or prevent cell cycle progression. (wikipedia.org)
  • Checkpoint control kinases is a term used to describe a group of enzymes that regulate progression of a cell through the cell cycle. (tocris.com)
  • Epidemiologic, animal, and laboratory studies suggest that 5-amino-salicylic acid (5-ASA) protects from the development of CRC by altering cell cycle progression and by inducing apoptosis. (nih.gov)
  • In this study, we hypothesized that 5-ASA restrains cell cycle progression by activating checkpoint pathways in colorectal cell lines, which would prevent tumor development and improve genomic stability. (nih.gov)
  • We found that 5-ASA at concentrations between 10 and 40 mmol/L affects cell cycle progression by inducing cells to accumulate in the S phase. (nih.gov)
  • Regulatory signaling systems that control the progression of the CELL CYCLE through the G1 PHASE and allow transition to S PHASE when the cells are ready to undergo DNA REPLICATION. (umassmed.edu)
  • Therefore it would be interesting to examine the control mechanism of cell cycle progression in which RSK1 affects Myt1 in meiosis and Plk1 affects Myt1 in mitosis. (biospraysehatalami.com)
  • Cdh1 was dispensable for viability and cell cycle progression. (elsevierpure.com)
  • The first project focuses on E2F1, a regulator of genes important for cell cycle progression and apoptosis. (mdanderson.org)
  • Molecular portraits of cell cycle checkpoint kinases in cancer evolution, progression, and treatment responsiveness. (uc.edu)
  • Concurrently, cell cycle progression underwent arrest at the G1/S checkpoint. (bvsalud.org)
  • AND c) Participant with EGFR sensitizing mutation or BRAF mutation or ALK/ROS alterations must be able to demonstrate progression of the disease on approved treatments for these conditions, in addition to platinum-based chemotherapy and immune checkpoint inhibitor. (who.int)
  • If DNA damage or abnormalities in spindle formation are detected at these checkpoints, the cell is forced to undergo programmed cell death, or apoptosis . (britannica.com)
  • For example, mutations in a protein called p53 , which normally detects abnormalities in DNA at the G1 checkpoint, can enable cancer-causing mutations to bypass this checkpoint and allow the cell to escape apoptosis. (britannica.com)
  • If cells containing damaged DNA were to divide, the errors would be transmitted to daughter cells, generating genomic instability and resulting in tumorigenesis or apoptosis . (tocris.com)
  • Wu X, Song M, Qiu P, Li F, Wang M, Zheng J, Wang Q, Xu F, Xiao H. A metabolite of nobiletin, 4'-demethylnobiletin and atorvastatin synergistically inhibits human colon cancer cell growth by inducing G0/G1 cell cycle arrest and apoptosis. (umassmed.edu)
  • Bufalin induces G0/G1 phase arrest through inhibiting the levels of cyclin D, cyclin E, CDK2 and CDK4, and triggers apoptosis via mitochondrial signaling pathway in T24 human bladder cancer cells. (umassmed.edu)
  • Blocking ROS generation by N -acetyl cysteine protects the cells from DIM-mediated G 2 /M arrest and apoptosis. (aspetjournals.org)
  • Reactivation of p53 in established tumors typically results in one of two cell fates, cell cycle arrest or apoptosis, but it remains unclear how this cell fate is determined. (nih.gov)
  • We hypothesized that high mitochondrial priming prior to p53 reactivation would lead to apoptosis, while low priming would lead to survival and cell cycle arrest. (nih.gov)
  • Using a panel of Kras-driven, p53 restorable cell lines derived from genetically engineered mouse models of lung adenocarcinoma and sarcoma (both of which undergo cell cycle arrest upon p53 restoration), as well as lymphoma (which instead undergo apoptosis), we show that the level of mitochondrial apoptotic priming is a critical determinant of p53 reactivation outcome. (nih.gov)
  • Cells with high initial priming (e.g., lymphomas) lacked sufficient reserve antiapoptotic capacity and underwent apoptosis after p53 restoration. (nih.gov)
  • Cancer genetics, DNA damage response, apoptosis, cell cycle My current research is focused on two transcription factors that respond to DNA damage and play important roles in regulating tumor development. (mdanderson.org)
  • If a cell has an error in its DNA that cannot be repaired, it may undergo self-destruction ( apoptosis ). (medlineplus.gov)
  • Apoptosis is a common process throughout life that helps the body get rid of cells that no longer work or that it doesn't need. (medlineplus.gov)
  • Apoptosis protects the body by removing genetically damaged cells that could lead to cancer, and it plays an important role in the development of the embryo and the maintenance of adult tissues. (medlineplus.gov)
  • A collection of basic cutting-edge techniques for studying the mechanisms underlying cell cycle regulation and checkpoint control. (buynsellbooksonline.com)
  • Taken together these findings provide insights into the regulation of Plk1 during cell division and diapause cyst formation and the correlation between the activity of Plk1 and RSK1. (biospraysehatalami.com)
  • Our results show that the Tuberin/CycB1 interaction regulates cell size and this regulation is nutrient dependent. (uwindsor.ca)
  • This study provides novel evidence for widespread alterations in DNA methylation during postnatal heart maturation and suggests that cardiomyocyte cell cycle arrest during the neonatal period is subject to regulation by DNA methylation. (nih.gov)
  • The key interests lie within the field of genome integrity and variation, cell division, regulation of gene expression, protein turnover and signal transduction. (ki.se)
  • Tight regulation of this process ensures that a dividing cell's DNA is copied properly, any errors in the DNA are repaired, and each daughter cell receives a full set of chromosomes. (medlineplus.gov)
  • Disruption of normal regulation of the cell cycle can lead to diseases such as cancer. (medlineplus.gov)
  • Checkpoint control kinases function to halt the cell cycle at these critical points. (tocris.com)
  • Tocris offers the following scientific literature for Checkpoint Control Kinases to showcase our products. (tocris.com)
  • Cell department is controlled through cooperation of different kinases. (biospraysehatalami.com)
  • Cancer cells that are defective in p53 function are deficient in their ability to transcriptionally upregulate the CDK inhibitor p21 after genotoxic stress. (nature.com)
  • Treatment with the novel cyclophilin inhibitor NV651, presented a potent antiproliferative effect in HCC cell lines via cell cycle perturbations arresting cells in the mitotic phase. (lu.se)
  • CHICAGO - A new standard of care for patients with chemotherapy-naive persistent, recurrent, or metastatic cervical cancer is first-line therapy with the combination of the immune checkpoint inhibitor pembrolizumab (Keytruda) with platinum-based chemotherapy and paclitaxel ― with or without bevacizumab. (medscape.com)
  • and the M (mitosis) phase, during which the duplicated chromosomes (known as the sister chromatids) separate into two daughter nuclei, and the cell divides into two daughter cells, each with a full copy of DNA. (wikipedia.org)
  • Likewise, a checkpoint during mitosis ensures that the cell's spindle fibres are properly aligned in metaphase before the chromosomes are separated in anaphase. (britannica.com)
  • Nup160 and Nup96 (components of the Nup107-160 nucleoporin complex) localize at spindle poles during mitosis in HeLa cells whereas Nup93 and Nup62 (nucleoporins absent from the Nup107-160 complex)do n. (ucsd.edu)
  • Having a better understanding of how specific changes in this large protein alters fundamental cell biology such as cell proliferation and cell size can ultimately help to effectively treat patients with these specific mutations. (uwindsor.ca)
  • CMB is comprised of more than 30 independent research groups organized in three themes: Cell Biology, Developmental and Stem Cell Biology and Infection and Cancer. (ki.se)
  • The central aim of the research within the Cell Biology theme is to gain a deeper understanding of the biology of the eukaryotic cell. (ki.se)
  • Thus the theme encloses expertise within bioinformatics, biophysics, biochemistry, molecular cell biology and genetics. (ki.se)
  • The stem cell and developmental biology program at CMB is engaged in a broad range of basic research aimed at understanding the molecular mechanisms underlying diverse aspects of embryonic development and tissue regeneration. (ki.se)
  • Basic genetic and molecular biology methodologies are combined with complementary bioinformatic and genome-wide approaches, allowing investigation global molecular changes in cells in various differentiation processes. (ki.se)
  • Since then, I have worked on mammalian cell biology, in my postdoctoral positions at the European Molecular Biology Laboratory (France) and the Centre for Cancer Biology (AUSTRALIA). (edu.au)
  • I have published seminal papers on circular RNAs and other molecular biology-rich projects in eukarytotes in Cell(x2) , Nature Biotechnology , Nature Plants, The EMBO Journal (x2), RNA, Genome Biology and other top-ranking journals (20 publications in the past 5 years), with an h-index of 25 at over 100 citations per article. (edu.au)
  • In June 2018, Dr. Maity became a research associate in the Vascular Biology and Stem Cell Research Laboratory in the department of Pharmaceutical Sciences at Texas Tech University Health Sciences Center, Amarillo. (nih.gov)
  • Dr. Jyoitirindra Maity has focused on cellular and molecular biology in rare disease models and cancer and stem cell modeling throughout his career. (nih.gov)
  • Link to all annotated objects annotated to obsolete detection of stimulus involved in mitotic cell cycle checkpoint. (planteome.org)
  • Finally, transcription factors within the nucleus must initiate the transcription of genes involved in cell proliferation. (britannica.com)
  • SL originally described a relationship between two genes, where alteration of either gene alone results in viable cells, but alteration (mutation, loss, or inhibition) of both genes simultaneously was lethal. (nature.com)
  • Because BRCA mutations are observed in fewer than 10% of cancer patients (cBioPortal: 6.7%) 11 , 12 , 13 the identification of additional genes that share synthetic lethal sensitivity relationships with mutated oncogenes or tumor suppressors would greatly enhance the implementation of tumor cell-specific synthetic lethal sensitivity to improve an anticancer therapeutic response. (nature.com)
  • Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. (thebiogrid.org)
  • How do genes control the growth and division of cells? (medlineplus.gov)
  • A variety of genes are involved in the control of cell growth and division. (medlineplus.gov)
  • The cell cycle has checkpoints (also called restriction points), which allow certain genes to check for problems and halt the cycle for repairs if something goes wrong. (medlineplus.gov)
  • We could confirm the increased polyploidy upon Mps1 inhibition in neuroblastoma cell lines and PDX model, leading to mitotic catastrophe activating the caspase-dependent mitochondrial apoptotic pathway. (lu.se)
  • The activation of replication checkpoint may slow down DNA replication and improve DNA replication fidelity, which increases the maintenance of genomic stability and counteracts carcinogenesis. (nih.gov)
  • Targeting ATR/CHK1 cell cycle checkpoint is a new approach in the post-PARPi era. (nih.gov)
  • Because most tumors are deficient in one or more aspects of the function of the p53 tumor suppressor, either as a consequence of mutations within p53, or impairment of upstream and downstream modulators of p53 activity 19 , targeting MK2 has the potential to selectively enhance tumor cell killing without increasing the genotoxic effects of chemotherapy on normal p53-wild type tissues. (nature.com)
  • Uncontrolled cell proliferation upon knockdown confirms the function of Tsp2A as tumor suppressor Z-DQMD-FMK furthermore to its function in sSJ framework and transepithelial transportation. (petrocollapse.org)
  • When the cell cycle proceeds without control, cells can divide without order and accumulate genetic errors that can lead to a cancerous tumor . (medlineplus.gov)
  • Basal cell carcinoma (BCC) is a nonmelanocytic skin cancer (ie, an epithelial tumor) that arises from basal cells (ie, small, round cells found in the lower layer of the epidermis). (medscape.com)
  • Development of most solid tumors is characterized by an increase in secretion and activation of matrix metalloproteinases (MMPs) produced by either the tumor cells or tumor-associated fibroblasts. (bvsalud.org)
  • 2+ in intensity in archival tumor sample (or if not available fresh biopsy sample) involving at least 50 % of the tumor cell population as demonstrated prospectively by a centrally assessed ICH assay. (who.int)
  • Initial exponential tumor growth is followed by a plateau phase when cell death nearly equals the rate of formation of daughter cells. (msdmanuals.com)
  • and the metaphase-to-anaphase transition, also known as the spindle checkpoint. (wikipedia.org)
  • Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. (tocris.com)
  • It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death. (tocris.com)
  • These findings establish a mechanism for co-targeting DNA damage-induced cell cycle checkpoints in combination with repair of cisplatin-DNA lesions in vivo using RNAi nanocarriers, and motivate further exploration of ASL as a generalized strategy to improve cancer treatment. (nature.com)
  • We evaluated the effect of 3,3′-diindolylmethane (DIM) in ovarian cancer cells. (aspetjournals.org)
  • DIM treatment inhibited the growth of SKOV-3, TOV-21G, and OVCAR-3 ovarian cancer cells in both a dose- and time-dependent manner with effective concentrations ranging from 40 to 100 μM. (aspetjournals.org)
  • These results clearly indicate the requirement of Chk2 activation to cause G 2 /M arrest by DIM in ovarian cancer cells. (aspetjournals.org)
  • Our results establish Chk2 as a potent molecular target of DIM in ovarian cancer cells and provide the rationale for further clinical investigation of DIM. (aspetjournals.org)
  • Recent studies have examined the consequences of epigenetic marks and cell cycle control, which has led to more research regarding cell division cancer, emphasizing the fact that the cell division process requires accurate checkpoints to avoid genetic damage. (ptgcn.com)
  • Through detailed characterization of fundamental molecular mechanisms of normal and perturbed cells, the theme strives to unravel information that increases the understanding of various diseases such as cancer and neurodegenerative, cardiovascular and inflammatory disorders. (ki.se)
  • Microtubule-associated protein MAP1LC3C regulates lysosomal exocytosis and induces zinc reprogramming in renal cancer cells. (uc.edu)
  • The human ribosomes are the cellular machines that participate in protein synthesis, which is deeply affected during cancer transformation by different oncoproteins and is shown to provide cancer cell proliferation and therefore biomass. (bvsalud.org)
  • Here we review the role of different drugs that may decrease ribosome biogenesis and cancer cell proliferation. (bvsalud.org)
  • In the present study, we evaluated the chemopreventive properties of the natural sesquiterpene ß-caryophyllene towards the damage induced by cigarette smoke condensate (CSC) in triple negative breast cancer MDA-MB-468 cells. (bvsalud.org)
  • Targeting the cell cycle has been proposed as a therapeutic strategy in cancer treatment with special interest in the mitotic phase. (lu.se)
  • Randomized, Open Label Phase 3 study of SAR408701 versus Docetaxel in Previously Treated metastatic non-squamous Non-Small Cell Lung Cancer patients with CEACAM5 positive tumors. (who.int)
  • Many factors are involved in causing and permitting the unregulated proliferation of cells that occurs in cancer. (msdmanuals.com)
  • Overview of Cancer Cancer is an unregulated proliferation of cells. (msdmanuals.com)
  • Cancer cells, particularly those arising from the bone marrow or lymphatic system, may have a short generation time, and there usually are a smaller percentage of cells in G0 (resting phase). (msdmanuals.com)
  • A subpopulation of cells within a cancer has the properties of stem cells. (msdmanuals.com)
  • A cancer may release cells into the circulation at a very early stage of development. (msdmanuals.com)
  • Circulating cancer cells are present in many patients with advanced cancer and even in some with localized disease. (msdmanuals.com)
  • Although most circulating cancer cells die, an occasional cell may penetrate into tissues, generating a metastasis at a distant site. (msdmanuals.com)
  • Experiments suggest that the abilities to invade, migrate, and successfully implant and stimulate new blood vessel growth are all important properties of the cells that cause metastases, which are likely a subpopulation of the primary cancer. (msdmanuals.com)
  • Cancer cells often present neoantigens on their cell surface that can be detected as "non-self" by the immune system, resulting in an attack by the immune system. (msdmanuals.com)
  • For a cell to progress through the cycle and replicate, it must pass through checkpoints between phases to ensure that DNA is replicated correctly and that chromosomes segregate. (tocris.com)
  • The mammalian cell can be thought of as an information processing unit, much like a computer. (mtsu.edu)
  • This is based on final overall survival results from the phase 3 randomized KEYNOTE-826 study , which showed that adding immunotherapy resulted in a 40% reduction in risk of death compared with chemotherapy alone for women with advanced cervical cancers expressing programmed cell death-ligand-1 (PD-L1). (medscape.com)
  • a) Having progressive disease during or after platinum-based chemotherapy (at least 2 cycles). (who.int)
  • It is our hypothesis that these mutations can affect the Tuberin/CycB1 interaction and result in dysregulation of cell proliferation and cell size. (uwindsor.ca)
  • Rad53 phosphorylation/activation is elicited when unrepaired meiosis-specific DSBs escape the recombination checkpoint. (unimi.it)
  • The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a mitotic cell cycle checkpoint. (planteome.org)
  • My Honours project studied mouse ES cell differentiation and the molecular basis of cell cycle checkpoint acquisition. (edu.au)
  • 6 families appear to have been lost from nematodes, based on their presence in fly, human and more basal organisms ( Table 1 ), and several new families have been invented within the coelomate lineage, whose functions predominantly map to immunity/angiogenesis, neurobiology, cell cycle and morphogenesis. (wormbook.org)
  • Using various cell lines, including normal and WRN mutant fibroblast lines, Dr. Maity's previous research showed that WRN mutant cells respond weakly to different stress-induced autophagy in addition to basal levels. (nih.gov)
  • WRN critically regulates autophagy in various cellular stresses, including starvation, endoplasmic reticulum (ER) stress conditions to rescue the cell, and basal situations to restore proper cellular function. (nih.gov)
  • Basal cell carcinoma of the right lower lid. (medscape.com)
  • When activated, these different signaling networks result in varying cell fate decisions such as cell growth, division, differentiation, and cell death. (mtsu.edu)
  • This research aims at characterizing molecules and signals involved in controlling the undifferentiated state and self-renewal capacity of stem cells, and to develop methods to direct the differentiation of stem cells into clinically relevant cell types. (ki.se)
  • Uncovering how an entire class of non-coding RNAs, called circular RNAs, are formed and regulated across cell differentiation lead to a seminal publication in the field. (edu.au)
  • During his postdoc, he carried out research to determine the role of Kruppel-like factor 2 (KLF2) during osteoblast (OB) differentiation of dental pulp-derived stem cells (DPSC). (nih.gov)
  • During the cellular differentiation process, cellular metabolism alters as the cell prepares for ongoing changes. (nih.gov)
  • Simultaneous measurements of glycolysis and oxidative phosphorylation in live cells revealed that OB differentiation decreased the oxygen consumption rate, which indicates reduced ATP production and mitochondrial respiration. (nih.gov)
  • Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)
  • The G1 checkpoint, also known as the restriction point in mammalian cells and the start point in yeast, is the point at which the cell becomes committed to entering the cell cycle. (wikipedia.org)
  • As the cell progresses through G1, depending on internal and external conditions, it can either delay G1, enter a quiescent state known as G0, or proceed past the restriction point. (wikipedia.org)
  • To determine the potential sources of variability in IMT, we first use an existing model of the Rb-E2F network, which controls cell cycle entry at the restriction point. (mtsu.edu)
  • At the restriction point (R), mammalian cells irreversibly commit to divide. (ebi.ac.uk)
  • Our previous results indicate that 5-ASA improves replication fidelity in colorectal cells, an effect that is active in reducing mutations. (nih.gov)
  • The decision to commit to a new round of cell division occurs when the cell activates cyclin-CDK-dependent transcription which promotes entry into S phase. (wikipedia.org)
  • Here we reconcile these results and show that whereas many commonly used cell lines do not exhibit a G1 R, primary fibroblasts have a G1 R that is defined by a precise Cdk activity threshold and the activation of cell-cycle-dependent transcription. (ebi.ac.uk)
  • Transcription in each cell strain was also analyzed with high-density oligonucleotide DNA microarrays (HuGeneFL 6800, Affymetrix) Microarrays were prepared with total RNA collected after OTQ treatment. (cdc.gov)
  • Further clustering highlighted >400 species with increased expression after treatment in one or more of the cell strains, including metabolic enzymes and transcription factors. (cdc.gov)
  • This system acts like a timer, or a clock, which sets a fixed amount of time for the cell to spend in each phase of the cell cycle, while at the same time it also responds to information received from the processes it controls. (wikipedia.org)
  • Checkpoints at the end of G1 and at the beginning of G2 are designed to assess DNA for damage before and after S phase. (britannica.com)
  • Catastrophic genetic damage can occur if cells progress to the next phase of the cell cycle before the previous phase is properly completed. (tocris.com)
  • Our data demonstrate that 5-ASA causes cells to reversibly accumulate in S phase and activate an ATR-dependent checkpoint. (nih.gov)
  • G1 Phase Cell Cycle Checkpoints" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • DNA DAMAGE, or the deficiencies in specific cellular components or nutrients may cause the cells to halt before progressing through G1 phase. (umassmed.edu)
  • This graph shows the total number of publications written about "G1 Phase Cell Cycle Checkpoints" by people in this website by year, and whether "G1 Phase Cell Cycle Checkpoints" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "G1 Phase Cell Cycle Checkpoints" by people in Profiles. (umassmed.edu)
  • Growth-inhibitory effects of DIM were mediated by cell cycle arrest in G 2 /M phase in all the three cell lines. (aspetjournals.org)
  • Some drugs work only during a specific phase of the cell cycle, requiring prolonged administration to catch dividing cells during the phase of maximal sensitivity. (msdmanuals.com)
  • Furthermore, we found that Cdh1 -1- cells fail to maintain DNA damage-induced G 2 arrest and that Cdh1-APC is activated by X-irradiation-induced DNA damage. (elsevierpure.com)
  • Here we show that encysted embryos (cysts) of the primitive crustacean are ideal for such research because they undergo WNT7A complete cell cycle arrest when they enter diapause (a state of obligate dormancy). (biospraysehatalami.com)
  • Diapause embryos usually do not undergo cell DNA or department. (biospraysehatalami.com)
  • Key areas of investigation are the identification and functional characterization of stem cell niches in developing tissues and adult organs. (ki.se)
  • For a stimulatory signal to reach the nucleus and "turn on" cell division, four main steps must occur. (britannica.com)
  • Third, this activation must stimulate a signal to be transmitted, or transduced, from the receptor at the cell surface to the nucleus within the cell. (britannica.com)
  • This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. (avivasysbio.com)
  • To further establish the involvement of Chk2 in DIM-mediated G 2 /M arrest, cells were transfected with dominant-negative Chk2 (DN-Chk2). (aspetjournals.org)
  • Blocking Chk2 activation by DN-Chk2 completely protected cells from DIM-mediated G 2 /M arrest. (aspetjournals.org)
  • These results were further confirmed in Chk2 knockout DT40 lymphoma cells, in which DIM failed to cause cell cycle arrest. (aspetjournals.org)
  • Altogether, these data indicate that Rad53 prevents sister chromatid segregation in the presence of unrepaired programmed meiotic DSBs, thus providing a salvage mechanism ensuring genetic integrity in the gametes even in the absence of the recombination checkpoint. (unimi.it)
  • Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide, with over 40,000 new cases per year in the US. (medscape.com)
  • The recurrence is a serious prognostic influence in patients with oral squamous cell carcinoma (OSCC) 1-3 . (bvsalud.org)
  • 2014) 16 reported and compared the histologic, immunohistochemical and clinical features as well as the survival rates of carcinoma arising in patients with PVL (p-scca) and conventional squamous cell carcinoma (c-scca). (bvsalud.org)
  • Compared to the eukaryotic cell cycle, the prokaryotic cell cycle (known as binary fission) is relatively simple and quick: the chromosome replicates from the origin of replication, a new membrane is assembled, and the cell wall forms a septum which divides the cell into two. (wikipedia.org)
  • To obtain specific information, we performed cellular experiments in the T98G and U-87 MG glioblastoma cell lines to evaluate the role of PDIA3. (bvsalud.org)
  • First, a growth factor must bind to its receptor on the cell membrane . (britannica.com)
  • Cyclophilin overexpression is a common event in fibrotic tissues playing a key role in different stages of the fibrotic process, including inflammation, hepatocyte death, and activation of the hepatic stellate cells leading to increased collagen production. (lu.se)
  • Collectively, the presented approaches provide a greater understanding of how mammalian cells process information and the noise sources involved in temporal variability in cell cycle entry. (mtsu.edu)
  • The theoretical basis for marrow failure includes primary defects in or damage to the stem cell or the marrow microenvironment. (medscape.com)
  • External insults (eg, infections, radiation, drugs) may disrupt stem cell homeostasis in marrow environment, leading to altered growth. (medscape.com)