Cell cycle arrest kb cells. Medical search. Frequent questions

It induced apoptosis, suppressed cell migration and invasion, blocked cell cycle and phosphatidylinositol 3-kinase/ protein kinase B signaling pathway. (ijpsonline.com)
In yeast, rapamycin inhibits the TORC1 kinase signaling pathway causing rapid alteration in gene expression and ultimately cell cycle arrest in G 1 through mechanisms that are not fully understood. (researchsquare.com)

3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay was executed for determination of effects of piperine on breast cancer cell viability. (ijpsonline.com)
doi:10.7287/peerj.9626v0.1/reviews/1, Soković, M., Glamoclija, J., and Ciric, A. Thymol also caused a decrease in cell viability of prostate cancer (PC-3 cell line), and provoked cytotoxic effects (Pathania et al. (dieselok.md)
Cell viability or clonogenicity was tested by violet crystal assay. (biomedcentral.com)
Methods: Cell viability assays were used to assess the antiproliferative effects of different solvent extracts. (jclmm.com)
The purpose of this study was to analyze the aqueous extract of A.cherimola mill for cell viability, cell cycle, apoptosis detection, intracellular reactive oxygen species measurement, and protein characterization using western blotting. (jclmm.com)
Results: Cell viability was reduced by 47% treated with aqueous extract, demonstrating its selectivity for the line of breast cancer cells. (jclmm.com)
Cell viability/proliferation assays, cell cycle analysis by flow cytometry, immunodetection of specific histone and p53 acetylation marks, western blotting, siRNA and RT-qPCR. (biomedcentral.com)
Combination studies demonstrated that POH, MJ and cisplatin decreased viability, induced cell cycle arrest and activated TNFR1. (unlv.edu)
SquamouS cell carcinoma for the viability of the tumour cel s once skin lesions are also mutated in the ultraviolet they have become malignant (Rol ison (UV) radiation-induced skin lesions of A large number of HPV types have et al. (who.int)

How does p53 induce cell cycle arrest? (darkskiesfilm.com)
1) For example, the down-regulation of miR15s and miR - 16 - 1 in chronic lymphocytic leukaemia, prostate cancer and pituitary tumours, leading to the inhibition of tumour growth and induce cell cycle arrest at the G 1 - phase by target cell cycle regulators ( cyclin D1, cyclin E1, cyclin D3 and CDK6). (ukessays.com)
The available data suggest that USP7 inhibitors induce cell cycle arrest and apoptosis in cancer cells through the p53 pathway, and sensitize cancer cells to PARP inhibitor-induced cell death [ 18 ]. (biomedcentral.com)
It was demonstrated that these compounds induce cell cycle arrest and apoptosis by themselves or in combination with other agents. (unlv.edu)

In fact, several studies have shown that T2D induces senescence in multiple types of cells, including fibroblasts and endothelial cells ( 11 , 12 ). (frontiersin.org)
Human endothelial cells regulate survival and proliferation of human mast cells. (southernbiotech.com)
Annexin A2 (also called ANXA2) is mainly expressed in endothelial cells. (jcancer.org)
[ 2 ] Diagnosed in 50% of patients with VHL disease, these hemangiomas are composed of endothelial cells and pericytes. (medscape.com)

Let-7 Let-7 has an essential role in cell cycle and the differentiation of cell cycle terminals. (ukessays.com)
and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
It is involved in p53 pathways and is implicated in cell death/survival signaling, the cell cycle, and differentiation, thereby playing a regulatory role in carcinogenesis [ 12 ]. (hindawi.com)
1. Harriman GR, Kunimoto DY, Elliott JF, Paetkau V, Strober W. The role of IL-5 in IgA B cell differentiation. (southernbiotech.com)
This family, which includes epidermal growth factor receptor (EGFR), plays a pivotal role in normal cell growth, lineage determination, repair, and functional differentiation. (medscape.com)

The involvement of cell cycle check point arrest has been performed using flow cytometry analysis. (phcogj.com)
Cell apoptosis or cell cycle was analyzed by flow cytometry, and chromosome misalignment was observed by a fluorescent microscopy. (biomedcentral.com)

Despite the intrinsic ecto-ATPase activity of CHO cells, the effective concentration and kinetic profile of eATP was consistent with the established affinity of the P2Y2 receptor and the known kinetics of autophagy induction. (bvsalud.org)
Conversely, during starvation mTORC1 is inhibited and autophagy is induced by AMP-activated protein kinase (AMPK), leading to generation of intracellular nutrients and energy during degradation of non-functional or non-essential organelles or protein aggregates [ 4 , 6 ], in turn contributing to cell survival. (springer.com)
In vitro assays, compound 9m exhibited high potency against human breast and cervical cancer cells and induced tumor cell cycle arrest and autophagy. (figshare.com)

Moreover, eATP removal or P2Y2 receptor inhibition also suppressed the ShlA-induced exocytic expulsion of the bacteria from the host cell. (bvsalud.org)
The inhibition of cell proliferation and apoptosis on MDA-MB231 and MCF-7 cell lines occurred via the mitochondrial pathway and induction of oxidative damage to DNA through Bax/Bcl-2 modulation, decreased levels of procaspase-8, -9, -3, increased levels of cleaved caspase-3 and ROS, and also cell cycle arrest at S-phase (Jamali et al. (dieselok.md)
In MDA-MB-231 cells, ST caused a significant dose-dependent cell growth inhibition by 31- 63% (p ≤ 0.0001) in 48 h and 40-50% (p ≤ 0.0001) in 72 h. (biomedcentral.com)
The inhibition of Torc1 by rapamycin mimics nutrient starvation and causes an array of physiological changes that include global changes in gene expression, phosphorylation/dephosphorylation of various factors, decreased cell growth, degradation of proteins, and ultimately cell cycle arrest in the G 1 phase [4, 9-11]. (researchsquare.com)
Pharmacological USP7 inhibition by P5091 retarded cell proliferation and induced cell apoptosis. (biomedcentral.com)
USP7 inhibition induces cell apoptosis and cell cycle G2/M arrest, and overcomes taxane resistance by inducing the protein degradation of PLK1, resulting in chromosome misalignment in mitosis. (biomedcentral.com)
USP7 specifically dequbiquitinates and stabilizes both p53 and MDM2 to various degrees, and USP7 inhibition is expected to inactivate MDM2 and activate p53, thereby leading to cell cycle arrest or apoptosis in cancer cells with functional p53 signaling [ 10 ]. (biomedcentral.com)
ERKi treatment of cells drives the poly-ubiquitylation and proteasome-dependent turnover of ERK2 and pharmacological or genetic inhibition of Cullin-RING E3 ligases prevents this. (babraham.ac.uk)
Escape from G1 arrest during acute MEK inhibition drives the acquisition of drug resistance. (babraham.ac.uk)
This suggests that DNA replication following escape from G1 arrest in drug is more error prone and provides a potential explanation for the DNA damage observed under long-term RAF-MEK-ERK1/2 pathway inhibition. (babraham.ac.uk)
Knockdown of Annexin A2 significantly suppressed cell proliferation and invasion of NSCLCs cells, and the biological effect of Annexin A2 on proliferation and invasion was mediated by the inhibition of p53, which in turn, promoted cell cycle progression and EMT. (jcancer.org)
These include regulation of cell cycle, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling and inhibition of angiogenesis. (mdpi.com)

Clonogenic assay was implemented for checking the effect of piperine on clonogenic potency of breast cancer cells. (ijpsonline.com)
Cell migration and invasion was monitored by transwell chambers assay. (ijpsonline.com)
Western blotting assay was implemented to check the levels of phosphatidylinositol 3-kinase and protein kinase B. Results revealed that piperine induced dose reliant cytotoxicity in MCF-7 human breast cancer cells. (ijpsonline.com)
Acridine orange/ethidium bromine staining assay revealed that piperine induced apoptosis in MCF-7 cells which was further investigated by Western blotting. (ijpsonline.com)
Cell growth assay, cell cycle analysis, FACS, JC-1 staining, annexin V staining and immunoblotting were used to study the efficacy of ST on cancer cells. (biomedcentral.com)
An early apoptosis induction in HepG2 cells was observed by annexin V assay, which clearly exhibited significantly increased early and late apoptosis phases both at 24 and 48 h. (phcogj.com)

[ 1 ] Early stage head and neck squamous cell carcinoma (HNSCC) is treated relatively well with single-modality therapy (either surgery or radiation alone). (medscape.com)
With the increased understanding of molecular mechanisms and basic pathways in the pathogenesis of squamous cell cancer of the head and neck , these pathways may be modified, and rational approaches in cancer therapy at the molecular level may be created. (medscape.com)
Go to Imaging of Nasopharyngeal and Laryngeal Squamous Cell Carcinoma and Head and Neck Squamous Cell Carcinoma for complete information on these topics. (medscape.com)
NSCLCs including adenocarcinoma, squamous cell carcinoma and large cell carcinoma, constitute 80% of all lung cancers [ 2 ]. (jcancer.org)

The immune system plays a key role in surveillance against cancer, but some tumour cells evolve to escape immune elimination [ 4 ]. (biomedcentral.com)
Despite this, clinical responses are typically transient as tumour cells develop resistance. (babraham.ac.uk)
Drug-like molecules that can reprogram selected histone PTMs in tumour cells are therefore of interest as potential cancer chemopreventive agents. (biomedcentral.com)
Thus, drug-like molecules that target chromatin modifying enzymes to reprogram selected histone PTMs in tumour cells may have potential as cancer chemopreventive agents. (biomedcentral.com)

BC comprises of variant subtypes and those subtypes arise from basal progenitor or luminal progenitor cells undergoing different genetic mutations[ 2 ]. (ijpsonline.com)
Glioblastomas are intrinsic brain tumors believed to originate from neuroglial stem or progenitor cells. (frontiersin.org)
Endogenous D-cysteine plays a role in neural development by inhibiting proliferation of neural progenitor cells (NPCs) via protein kinase B (AKT) signaling mediated by the FoxO family of transcription factors. (d-aminoacids.com)

An option to eliminate the negative effects of chronic senescent cells is to kill them specifically, using compounds called senolytics (Figure 2), which target pathways activated in senescent cells [16]. (darkskiesfilm.com)
Stimulation of P2Y2-dependent pathways evokes the activation of a defensive response to counteract cell damage and promotes the nonlytic clearance of the pathogen from the infected cell. (bvsalud.org)
Furthermore, silencing TNFRSF13B expression resulted in decreased colony formation of 22Rv1 and PC-3 cells through modulating the cell cycle and p53 signalling pathways. (biomedcentral.com)
XLS 20 KB) Additional file 4: The most enrichment pathways among genes related to cell cycle, apoptosis, cell division and growth by KEGG. (cox-inhibitors.com)
Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)

Over lifetime, due to the action of several stressors such as DNA damage and telomere shortening, senescent cells accumulate in the organism and release a variety of pro-inflammatory cytokines responsible for low-grade inflammation. (frontiersin.org)
How do senescent cells accumulate? (darkskiesfilm.com)

Flow cytometric analysis evidenced that piperine arrested the cell cycle at growth 2/mitosis phase, hence suppressed the breast cancer progression. (ijpsonline.com)
It has complex functions and can inhibit cell apoptosis, promote cell transformation, participate in cell mitosis, angiogenesis, and cause tumor cells to develop drug resistance [ 7 , 8 ] . (researchsquare.com)
DSBs are first detected and signaled by the DNA damage checkpoint that triggers cell cycle arrest, providing time for the cell to repair damaged chromosomes before entering mitosis. (cea.fr)
Further studies showed that P5091 induced cell cycle arrest at G2/M phase, and particularly induced chromosome misalignment, indicating the key roles of USP7 in mitosis. (biomedcentral.com)
By overexpressing PLK1, USP7 that had been depleted by RNAi ceased to induce chromosome misalignment in mitosis and again supported cell proliferation and cell survival. (biomedcentral.com)

Upon contact with the host epithelial cell and prior to internalization, Serratia induces an early autophagic response that is entirely dependent on the ShlA toxin. (bvsalud.org)
Here, we evaluated the efficacy of ST on three different human cancer cell lines including skin epidermoid carcinoma A431 cells, lung epithelial carcinoma A549 cells and breast adenocarcinoma MDA-MB-231. (biomedcentral.com)
mmc9.pdf (66K) GUID:?55F9BD4F-0F85-40B3-99F0-75E20D3D96BC Supplemental Physique?S10 Silencing p21 reversed cell cycle G2/M arrest of TGF-1Ctreated proximal tubular epithelial cells. (holyexperiment.org)
We investigated the role of CAL-101 (GS-1101, Idelalisib) TGF-1 in inducing profibrotic signaling from epithelial cells to activate pericyte-myofibroblast transition. (holyexperiment.org)
In addition, epithelial cell cycle G2/M arrest and production of profibrotic cytokines were both attenuated. (holyexperiment.org)
Mechanistically, our studies showed that knockdown of Annexin A2 increased the expression of p53, which in turn, induced cell cycle G2 arrest and inhibited epithelial-to-mesenchymal transition (EMT). (jcancer.org)

Mechanisms regulating cardiomyocyte cell cycle arrest are of great interest partly because reversing this process could provide a way to stimulate cardiac regeneration after injury [ 17 ]. (springer.com)

Reduces concentration of inflammatory cytokines IL-1α, IL-6, IL-10 and TNF-a (inflammation markers) in macrophages (immune cells). (natural-souls.com)
In one study, researchers examined the ability of red raspberries to inhibit inflammatory immune cells (called macrophages) taken from colitis-affected animals. (newsmax.com)
14. Zizzo G, Hilliard BA, Monestier M, Cohen PL. Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction. (southernbiotech.com)
Molecular 'switch' reverses chronic inflammation and aging - Science Daily, 2/6/20 - 'By studying mice and immune cells called macrophages, the team found that a protein called SIRT2 is responsible for deacetylating the NLRP3 inflammasome. (qualitycounts.com)

While the origin of these tumors is still not definitively known, the two theories with the most support suggest that these tumors arise from a primitive cell derived either from an embryologic tissue called the neural crest, or from resident cells in the body (called mesenchymal stem cells) that have a capability to become one of a variety of tissue types. (sarcomahelp.org)

T he presence and activity of various proteins are required in the cell cycle progression. (ukessays.com)

In sum, eATP operates as the key signaling molecule that allows the eukaryotic cell to detect the challenge imposed by the contact with the ShlA toxin. (bvsalud.org)
The recently discovered typhoid toxin, which is encoded by Salmonella enterica , leads to cell cycle arrest in target cells ( 8 ). (cdc.gov)
The toxin binds Neu5Ac-terminated glycans, which are expressed exclusively in human cells, resulting in the pathogen's host specificity. (cdc.gov)
Cholesterol-rich membrane microdomains mediate cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal-distending toxin. (southernbiotech.com)
Various techniques have been developed for targeting cancer cells: gene therapy, monoclonal antibodies (MAbs), antibody toxin conjugates, small-molecule inhibitors, antisense molecules, and tumor vaccines. (medscape.com)

In conclusion, the current investigation regarding anticancer effects of piperine against breast cancer revealed remarkable suppression of cancer cells. (ijpsonline.com)
Rath P.C. and Mukhopadhyaya T. (2009) p53 gene expression and 2-methoxyestradiol treatment differentially induce NF-kB activation in human lung cancer cells with different p53 phenotypes, DNA Cell Biol. (jnu.ac.in)
2002). The Mechanism of Carvacrol-Evoked [Ca2+]i Rises and Non-ca2+-triggered Cell Death in OC2 Human Oral Cancer Cells. (dieselok.md)
To decrease side effects from non-specific cytotoxicity, new drugs, such as targeted agents, are being developed to selectively destroy specific cancer cells. (jcpjournal.org)
Blueberry, currant, cranberry, and a few others significantly reduced the growth of these cancers by inhibiting the reproduction of the cancer cells (a process called cell-cycle arrest). (newsmax.com)
While exploring the molecular changes associated with strong ST efficacy in breast cancer cells, we observed that ST induced cell cycle arrest as well as cell death. (biomedcentral.com)
This study provides valuable insight into the chemopreventive efficacy and associated molecular alterations of ST in breast cancer cells whereas it had only moderate efficacy on lung cancer cells and did not show any considerable effect on skin cancer cells. (biomedcentral.com)
Both USP7 and PLK1 were overexpressed in taxane-resistant cancer cells, and negatively correlated with the MP scores in tumor tissues. (biomedcentral.com)
Bergamottin also inhibits the clonogenic activity of the A549 cancer cells by reducing the number of cancer colony forming cells. (medchemexpress.com)
Conclusion: Our findings reveal that the aqueous extract of A. cherimola mill has anti-tumor properties by selectively inhibiting the breast cancer cells (MCF-7) and promoting their apoptosis. (jclmm.com)
In this study we assessed the effects of the phytocompounds garcinol and curcumin on histone and p53 modification in cancer cells, focussing on the breast tumour cell line MCF7. (biomedcentral.com)
In summary, although garcinol and curcumin can both inhibit histone acetyltransferase activities, our results show that these compounds have differential effects on cancer cells in culture. (biomedcentral.com)
Yeruva, Venkat Laxmi, "Molecular mechanism of methyl jasmonate induced apoptosis in human cancer cells" (2007). (unlv.edu)
The goal of specific molecular targets in cancer therapy is to create a "magic bullet" that selectively kills cancer cells. (medscape.com)
As our understanding of the molecular biology of HNSCC continues to develop, we can target the specific components of cancer cells that are not found in normal cells. (medscape.com)
Ideal targets should be both specific to cancer cells and commonly found in cancer cells. (medscape.com)
The goal of gene therapy is to introduce new genetic material into cancer cells that selectively kills them without causing toxicity to the surrounding cells. (medscape.com)

Renal cell carcinoma (RCC) incidence has increased over the past two decades. (hindawi.com)
Renal cell carcinoma (RCC) accounts for approximately 3% of human malignancies, and its incidence appears to be increasing globally [ 1 ]. (hindawi.com)
Clinical hallmarks of VHL disease include the development of retinal and central nervous system (CNS) hemangioblastomas (blood vessel tumors), pheochromocytomas , multiple cysts in the pancreas and kidneys, and an increased risk for malignant transformation of renal cysts into renal cell carcinoma. (medscape.com)
Early identification of VHL is important because of the increased risk of serious complications (eg, renal cell carcinoma) to foster more effective treatment options and better prognoses. (medscape.com)

Which gene causes cell-cycle arrest? (darkskiesfilm.com)
The survivin gene is 15 KB in length, located at 17q25, and has 4 exons and 3 introns. (researchsquare.com)
Materials and Methods Coll-GFP Mice Coll-GFP transgenic mice were generated around the C57BL6 background as described previously.2 In brief, 3.2 kb of CAL-101 (GS-1101, Idelalisib) the collagen I(1) (Col1a1) promoter and enhancer with the open reading frame of enhanced GFP yielded the highest levels of GFP expression when gene transcripts were generated. (holyexperiment.org)
Here, we hypothesized that specific histone residue(s) might be involved in facilitating gene expression such that cells mount a response to rapamycin. (researchsquare.com)
Our findings demonstrate that acquisition of MEK inhibitor resistance often occurs through gene amplification and can be suppressed by impeding cell cycle entry in drug. (babraham.ac.uk)
Targeted molecular therapy, like therapy with monoclonal antibodies, gene therapy, and other therapies, has limited or nonexistent side effects on normal cells of the body, unlike present modalities such as surgery, chemotherapy, and radiotherapy. (medscape.com)

It controls several genes that play a role in the arrest of the cell cycle, cellular senescence, DNA repair system, and apoptosis. (darkskiesfilm.com)
This then leads to the activation of a number of genes whose products trigger cell-cycle arrest, apoptosis, or DNA repair. (darkskiesfilm.com)
This study provides first demonstration for the global induction of apoptotic and cell cycle-related genes by 125I seed irradiation. (cox-inhibitors.com)
that 125I seed irradiation affects genes associated with apoptosis and cell cycle arrest in both transcriptional and epigenetic levels. (cox-inhibitors.com)
XLS 21 KB) Additional file 2: List of genes induced or repressed by 125I irradiation. (cox-inhibitors.com)
XLS 108 KB) Additional file 3: Biological processes overrepresented among the irradiation induced or repressed genes. (cox-inhibitors.com)
Mills DM, Bajaj V, Lee CA: A 40 kb chromosomal fragment encoding 4SC-202 molecular weight Salmonella typhimurium invasion genes is absent from the corresponding region of the Escherichia coli K-12 chromosome. (cox-inhibitors.com)
We show that the H2B R95A causes defects in the expression of a subset of genes of the pheromone pathway required for α factor-induced G 1 arrest. (researchsquare.com)
Chromosomes are the cellular storage units for genes contained within the nucleus (which is the genetic center) of the cell and are analogous to a spool with the DNA or genetic message being the thread on the spool. (sarcomahelp.org)
Humans have a duplicate set of 23 chromosomes (or a total of 46 chromosomes) in any given cell that carries all of the human genes. (sarcomahelp.org)
Selumetinib causes long-term G1 arrest accompanied by reduced expression of DNA replication and repair genes, but cells stochastically re-enter the cell cycle during treatment despite continued repression of pERK1/2. (babraham.ac.uk)
This task can be accomplished by replacing tumor suppressor genes that have been lost or mutated, selectively inserting genes that produce cytotoxic substances, or modifying the immune system to destroy the tumor cells. (medscape.com)

The foamy stromal cells between the capillaries stain positive for glial fibrillary acid protein and neuron-specific enolase. (medscape.com)

J Cell Biol (2015) 210 (2): 177-179. (rupress.org)
J. Cell Biol. (rupress.org)
Histochem Cell Biol. (southernbiotech.com)
In Vitro Cell Dev Biol Anim. (jclmm.com)

Furthermore, the TNFRSF13B was knocked down in 22Rv1 and PC-3 human prostate cancer cell lines via transfecting short hairpin RNAs and cell proliferation and colony formation assays were performed. (biomedcentral.com)

1) The regulation of these protein levels is vital for the understanding of the cell cycle control and its dysregulation. (ukessays.com)
2) Therefore, the proper control of protein levels is crucial for the cell cycle. (ukessays.com)
Temporary blockade of NKG2D signaling during the effector phase resulted in the formation of highly defective memory CD8 T cells characterized by altered expression of the ribosomal protein S6 and epigenetic modifiers, suggesting modifications in the T cell translational machinery and epigenetic programming. (bmj.com)
Temporary blockade of NKG2D signaling during the effector phase results in the formation of highly defective memory CD8 T cells potentially by affecting the expression of the ribosomal protein S6 and epigenetic modifiers, suggesting alterations in T cell translational machinery and epigenetic programming. (bmj.com)
Red raspberries also suppressed a protein complex called NF-kb, which drives inflammation. (newsmax.com)
ST caused G0/G1 cell cycle arrest which was accompanied by a decrease in CDK4 and cyclin D1, and an increase in p21/Cip1and p27/Kip1 protein levels. (biomedcentral.com)
In the presence of nutrients, mTORC1 is activated and promotes cell growth, including protein synthesis and energy storage. (springer.com)
USP7 was originally identified as a binding partner for the herpes simplex virus (HSV) infected cell protein and named herpes-associated ubiquitin-specific protease (HAUSP) [ 6 ]. (biomedcentral.com)
Given that protein aggregates in liver cells are closely linked to alcoholic liver disease, these findings suggest that quercetin could be a useful treatment for patients with this condition. (qualitycounts.com)

Vehicle-treated control cells did not show any hallmarks of apoptosis after 18 h of exposure to dimethyl sulphoxide. (up.ac.za)
Conversely, increased morphological hallmarks of apoptosis were observed in SNO-treated cells after 21.5 h of 2 ME exposure. (up.ac.za)
The present preliminary study suggests that the accumulation observed in metaphase cells and the increase in Cdc2 kinase activity caused by 2 ME are consistent with morphological hallmarks of mitotic arrest and disrupted mitotic spindle formation, thus leading to induction of apoptosis in SNO cells. (up.ac.za)

Several toxins, including ShlA, were shown to induce ATP efflux from eukaryotic cells. (bvsalud.org)
During the last decade, the non-random spatial arrangement of the genome into the nucleus of eukaryotic cells, as emerged as a key regulator of genome functions and notably of the propagation of a stable genome. (cea.fr)

The effects of 1 × 10-6 M exogenous 2-methoxyestradiol (2 ME) were determined on cell morphology and cell division cycle (Cdc) 2 kinase activity in SNO oesophageal carcinoma cells. (up.ac.za)

Loss of p53 function promotes (directly and indirectly) chromosomal instability, inducing cells to enter either senescence or apoptosis [13]. (darkskiesfilm.com)

Interest in ALMS1 is heightened by the recent discovery of its involvement in neonatal cardiomyocyte cell cycle arrest, a process with potential relevance to regenerative medicine. (springer.com)
Cell cycle involvement in cancer treatment with carvacrol and thymol. (dieselok.md)

Another consequence of aging is the accumulation of so-called senescent cells, normal cells that stop dividing, contribute to tissue aging and secrete substances like cytokines that induce inflammation. (qualitycounts.com)

Interleukin-15 (IL-15) is one the most well described factors needed for survival and homeostasis of memory and memory precursor cells, as blocking IL-15 signaling strongly reduces the number of memory CD8 T cells [ 4 , 5 ]. (bmj.com)
Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells. (southernbiotech.com)
The HER (erbB) family of transmembrane receptor tyrosine kinases is one of the cytostatic targets in tumor cell growth and survival. (medscape.com)

Once Serratia invades the eukaryotic cell and multiples inside an intracellular vacuole, ShlA expression also promotes an exocytic event that allows bacterial egress from the host cell without compromising its integrity. (bvsalud.org)
To test the hypothesis that escape from G1 arrest in drug promotes amplification, we exploited the combination of palbociclib and selumetinib. (babraham.ac.uk)

thus protecting the chromosome ends from being recognized by the cell as double-strand breaks, in addition to protection by proteins that bind the telomere. (rupress.org)
The blood circulating miRNA is mainly derived from a type of exosomes containing a variety of proteins and miRNAs that can be passed between cells and endocytic vesicles. (researchsquare.com)
the corresponding variant proteins were produced in E.coli (BL21) cells and characterized. (d-aminoacids.com)

Immunodeficiencies are genetic diseases known to predispose an individual to cancer owing to defective immunity towards malignant cells. (biomedcentral.com)
Herein, we screened a histone mutant collection and report that one of the mutants, H2B R95A, is strikingly resistant to rapamycin due to a defective cell cycle arrest. (researchsquare.com)

MECHANISM OF CELL-CYCLE ARREST BY p53 Cell-cycle arrest by p53 is mainly mediated by the transcriptional activation of p21/WAF1 (el-Deiry et al. (darkskiesfilm.com)
We validate our approach in two ways: by demonstrating that it accurately models expression data and by demonstrating that our reconstructed model is similar to previously-published models of transcriptional regulation of the cell cycle. (biomedcentral.com)
Our regression-based approach allows us to build a general model of transcriptional regulation of the yeast cell cycle that includes additional factors and couplings not reported in previously-published models. (biomedcentral.com)

Further, cell death effect of ST was associated with induction of apoptosis. (biomedcentral.com)

Enzymatic removal of accumulated extracellular ATP (eATP) or pharmacological blockage of the eATP-P2Y2 purinergic receptor inhibited the ShlA-promoted autophagic response in CHO cells. (bvsalud.org)
This process of certification assures that the memory compartment is filled with CD8 T cells that have demonstrated their ability to kill their cognate targets through a two-step process that utilizes T cell receptor (TCR) and NKG2D signaling. (bmj.com)

Neonatal murine epidermal cells express a functional multidrug-resistant pump. (southernbiotech.com)

It could be divided into two categories, small cell lung cancers (SCLCs) and non-small cell lung cancers (NSCLCs). (jcancer.org)
These effects of honey have been thoroughly investigated in certain cancers such as breast, liver and colorectal cancer cell lines. (mdpi.com)

Mishra RR, Chaudhary JK, Bajaj GD, Rath PC (2011) A novel human TPIP splice-variant (TPIP-C2) mRNA, expressed in human and mouse tissues, strongly inhibits cell growth in HeLa cells. (jnu.ac.in)
Furthermore, TSC1 was demonstrated to be required for the proper activation of the transforming growth factor-β (TGF-β)-SMAD2/3 pathway in HeLa cells [ 11 ]. (springer.com)

Whereas similar ST treatments moderately inhibited the growth of A549 cells by up to 13% (p ≤ 0.05) in 48 h and 14% (p ≤ 0.05-0.0001) in 72 h. (biomedcentral.com)
Bergamottin has potent antiproliferative effects on the A549 cells. (medchemexpress.com)
Tumors are induced in the mice by injecting non-small cell lung cancer A549 cells (1×10 6 cells/mouse). (medchemexpress.com)
This study investigated the cytotoxic activity of four plant derived compounds including perillic acid (PA), Perillyl alcohol (POH), cis jasmone (CJ) and methyl jasmonate (MJ) on a variety of human cancer cell lines: Breast (MDA-MB-435, MDA-MB-231, DC4, DB46, T47D, SKBR3 and ZR75-1), Prostate (PC-3 and DU-145) and Lung (A549, H520 and H2170). (unlv.edu)

for example, human telomeres are 2-20 kb of (TTAGGG) n repeats. (rupress.org)
Rath P.C. (2005) Relationship between constitutive Nuclear Factor-kappaB (NF-kB) and Inhibitor kappaB-alpha (IkB-a) in an Interferon-a-sensitive human Burkitt lymphoma cell line. (jnu.ac.in)
The current study found that ST has the capacity to induce cell toxicity in human liver cells. (phcogj.com)
Collectively, results presented in this study demonstrated that the ST, which is used as a euphoritic substance of abuse also, has significant level of toxicity in human cells. (phcogj.com)
Cytotoxic and cytostatic effects of four Annonaceae plants on human cancer cell lines. (jclmm.com)
In this study, we showed that Annexin A2 was evidently overexpressed in human NSCLCs cell lines and NSCLCs tissues. (jcancer.org)

Many studies showed that p53 cell-cycle and apoptosis functions are important for preventing tumor development. (darkskiesfilm.com)

In damaged cells, p53 is activated and causes cell cycle arrest by inducing p21 and by inhibiting pRb phosphorylation by Cdks. (darkskiesfilm.com)
Reduced SMO-dependent expression of Gli1 was demonstrated in both Tsc1 −/− and Tsc2 −/− cells, and we found that Tsc1 is required for TGF-β induced phosphorylation of SMAD2/3 and subsequent expression of the HH signaling effector and transcription factor GLI2. (springer.com)
Rapamycin-induced G 1 arrest does not involve detectable phosphorylation of the MAPKs, Kss1 and Fus3, as reported for α factor-induced G 1 arrest. (researchsquare.com)
Once recruited to DSB, these complexes get activated and induce the phosphorylation of numerous targets including transducing kinases, which subsequently phosphorylate downstream effectors to delay cell cycle and promote DNA repair. (cea.fr)

These results suggest prominent in vitro anti-proliferative and pro-apoptotic effects of ST in MDA-MB-231 cells. (biomedcentral.com)

Moreover the ST extract was able to arrest the cell cycle check point at G2/M phase. (phcogj.com)
The good herb: Buckwheat liquor helps cells clean house - Science Daily, 8/16/21 - 'When the researchers looked more closely at specific components of tartary buckwheat extract, they found that one component, quercetin, had the same effects as the extract. (qualitycounts.com)

Methods One week after immunization with peptide-pulsed dendritic cells, NKG2D signaling was transiently blocked in vivo with a single injection of neutralizing antibodies. (bmj.com)

p21 mediates its various biological activities primarily by binding to and inhibiting the kinase activity of the cyclin-dependent kinases (CDKs) CDK2 and CDK1 (also known as CDC2) leading to growth arrest at specific stages in the cell cycle (FIG. 2). (darkskiesfilm.com)
Our data provide a new insight whereby rapamycin signaling via the Torc1 kinase may exploit the pheromone pathway to arrest cells in the G 1 phase. (researchsquare.com)

Garcinol treatment alters expression of chromatin modifying enzymes in MCF7 cells, resulting in reprogramming of key histone and p53 PTMs and growth arrest, underscoring its potential as a cancer chemopreventive agent. (biomedcentral.com)

Another study found that giving daily blueberry powder to men and women significantly increased the number of natural killer white blood cells (NK cells) in both the men and the women. (newsmax.com)
A significantly increasing pattern of hypodiploid phases of cells also been observed, which confirm the apoptosis induction again. (phcogj.com)
Either USP7 or PLK1 knockdown by RNAi significantly sensitized taxane-resistant cells to taxane cell killing. (biomedcentral.com)
Moreover, we found that knockdown of Annexin A2 significantly suppressed cell proliferation and invasion of NSCLCs cells. (jcancer.org)

This revealed increased expression of B-cell lymphoma 2 associated X and reduced expression of B-cell lymphoma 2, indicating apoptosis induction by piperine. (ijpsonline.com)

Because age-related cellular senescence and type 2 diabetes (T2D) have been recognised as risk factors for CRC development, the recent finding that type 2 diabetic patients present an elevated circulating volume of senescent cells raises the question whether type 2 diabetes facilitates the process of CRC tumorigenesis by inducing premature cell senescence. (frontiersin.org)
Senescence is a stress-response cellular state characterised by proliferative arrest but active metabolism ( 7 ). (frontiersin.org)

The purpose of this in-vitro research is to investigate the possible anti-cancer efficacy of several solvent extracts of Annona cherimola mill in breast cancer cell lines, namely MCF-7. (jclmm.com)

Nevertheless, sphingosine, an intracellular signalling lipid, greatly increases the release of neurotransmitters in neuronal and neuroendocrine cells, affecting the exocytotic fusion mode through the direct interaction with SNAREs. (bvsalud.org)

To monitor morphology of cancerous breast cells, phase contrast microscopy was performed after piperine exposure. (ijpsonline.com)

In contrast, here we focus on reverse-engineering the network of relationships among transcription factors that regulate the cell cycle in S. cerevisiae . (biomedcentral.com)
We have developed a technique to reverse-engineer networks of the time-dependent activities of transcription factors that regulate the cell cycle in S. cerevisiae . (biomedcentral.com)

Tumors in the Ewing's family of sarcomas are made of primitive cells, which are cells that haven't yet decided what type of cell they are. (sarcomahelp.org)

The aberrant accumulation of senescent cells with age results in potential detrimental effects. (darkskiesfilm.com)
This study concluded that senescent cell accumulation results from a combination of two effects. (darkskiesfilm.com)

Anatomy14

Organisms12

Diseases7

Chemicals and Drugs86

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Phenomena and Processes62

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Health Care2

Signaling pathway2

Viability9

Induce cell cycle arrest4

Endothelial cells4

Differentiation6

Flow cytometry2

Autophagy3

Inhibition12

Assay6

Squamous4

Tumour cells4

Progenitor cells3

Pathways5

Senescent cells accumulate2

Mitosis5

Epithelial6

Mechanisms1

Macrophages4

Mesenchymal Stem1

Progression1

Toxin5

Cancer cells17

Renal Cell Carc4

Gene6

Genes12

Stromal Cells1

Biol4

Assays1

Protein9

Hallmarks3

Eukaryotic cells2

Carcinoma Cells1

Chromosomal1

Involvement2

Cytokines1

Survival3

Promotes2

Proteins3

Defective2

Transcriptional3

Induction of apoptosis1

Receptor2

Neonatal1

Cancers2

HeLa2

A5494

Human6

Studies showed1

Phosphorylation4

Apoptotic1

Extract2

Methods1

Kinase2

Growth arrest1

Significantly4

Apoptosis induction1

Cellular2

Breast Cancer1

Intracellular1

Morphology1

Transcription factors2

Tumors1

Accumulation2