Cell cycle analysis over expression cell cycle. Medical search. Frequent questions

TYRO3 or AXL gene knockdown reduced cell proliferation/colony formation. (nature.com)
Cell proliferation includes a series of events that is tightly regulated by several checkpoints and layers of control mechanisms. (frontiersin.org)
In conclusion, we provide useful experimental approaches and bioinformatics to identify informative and predictive genes at the single-cell level, which opens up new means to describe and understand cell proliferation and subpopulation dynamics. (frontiersin.org)
However, most of our knowledge about cell proliferation comes from studies that average data from large and mixed cell populations. (frontiersin.org)
In addition, their osteogenic differentiation potential was increased, and genes involved in cell adhesion, FGF-2 signalling, cell cycle, stemness, cell differentiation, and cell proliferation were upregulated, compared to that of the MSCs cultured on uncoated plates. (hindawi.com)
Pathways associated with cell cycle and proliferation were markedly upregulated in muscle-invasive and grade 3 cancers. (urotoday.com)
Cell cycle analysis showed that visfatin increased S-stage percentage and proliferation index in a dose- and time-dependent manner. (thieme-connect.com)
Our results further indicate that MCT4 promotes proliferation and survival by altered cell cycle regulation and cell death mechanisms. (hindawi.com)
For this purpose, we designed an MCT4 overexpression and knockdown/inhibition model to explore the functional consequences of MCT4 expression on cancer cell metabolism, survival, proliferation, migration, invasion potential, and angiogenesis as well as on cell cycle profiles and cell death mechanisms. (hindawi.com)
Further, the results of miR-4755-5p mimic transfection confirmed that under the action of NaF, miR-4755-5p overexpression reduced Cyclin D1 protein expression within osteoblasts and further inhibited cell proliferation and activation. (fluoridealert.org)
An MTT assay was used to assess cell proliferation. (spandidos-publications.com)
In-depth study of small non-coding RNA molecules confirmed that microRNA (miR) has an important regulatory role in cell proliferation, differentiation, metabolism, apoptosis and development processes ( 3 ). (spandidos-publications.com)
Under in vitro conditions, changes in the proliferation and invasion ability were detected in myeloma cells. (spandidos-publications.com)
The latter findings point to the participation of Nogo-A/NgR1 signaling in the regulation of other aspects of growth, such as tissue expansion or turnover by cell proliferation. (jneurosci.org)
Fractional extracts (n-hexane, ethyl acetate, and ethanol) and the dominant compounds (morin, resveratrol, and quercetin) were examined for their abilities on cytotoxicity, antioxidant, anti-inflammation, and antileukaemic activity (Wilms' tumour 1 protein was used as a well-known biomarker for leukaemic cell proliferation). (bvsalud.org)
In particular, resveratrol demonstrated a noteworthy decreased Wilms' tumour 1 protein expression and a reduction in cell proliferation across all cells. (bvsalud.org)
10] Interestingly, this analysis found no differences in expression of proliferation markers between these subsets of CD207+ cells, consistent with the hypothesis that LCH may be a disease of abnormal cellular accumulation. (medscape.com)
Similarly, depletion in the STRIPAK component STRIP1 affects activation of GCKIII kinases and cell cycle disruption through elevated expression of cyclin dependent kinase inhibitors p21 and p27, enhanced levels of which lead to a protective effect from therapeutic treatments and increased proliferation. (lu.se)
ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)
or physiological or as a description of key events and processes starting toxic effects that affect cell proliferation. (cdc.gov)

Cell cycle and apoptosis are key pathways of multicellular homeostasis and deregulation of these pathways is associated with cancerogenesis. (oncotarget.com)
Eight genes related to apoptosis and ten genes regulating key points of cell cycle were investigated. (oncotarget.com)
It can further allow these cells to stop their functions and differentiations to undergo a programmed cell death process called apoptosis. (wikipedia.org)
Furthermore, the withdrawal process could allow cells to encounter further parts of their cell life, namely senescence and natural apoptosis. (wikipedia.org)
This is the peer-reviewed version of the article: Jovanovic KK, Tanic M, Ivanovic I, Gligorijević N, Dojčinović B, Radulovic S. Cell cycle, apoptosis, cellular uptake and whole-transcriptome microarray gene expression analysis of HeLa cells treated with a ruthenium(II)-arene complex with an isoquinoline-3-carboxylic acid ligand. (ac.rs)
At the cellular and whole organ level, degenerative changes that are a hallmark of natural aging (shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, and apoptosis, accompanied by diminished elasticity) reach pathological levels in aging humans in the form of chronic respiratory disease. (karger.com)
upregulated by Bic (60 M) which eventually resulted in cell apoptosis. (mingsheng88.org)
Further experiments showed that the combination treatment induced autophagy and late apoptosis in MDA-MB-231 cells. (umass.edu)
These differences were found in genes involved in cell cycle regulation, apoptosis, cell signaling, metastasis, and myeloid differentiation. (medscape.com)

The differentiation of mesenchymal stem cells (MSCs) into multiple cell lineages can be exploited as an attractive strategy for cell-based therapy and regenerative medicine [ 1 ]. (hindawi.com)
The ECM provides structural and biochemical support to the cells and has various other functions including cell adhesion, cell to cell communication, and differentiation [ 17 , 18 ]. (hindawi.com)
S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (cancerindex.org)
Allowing the comparison of the RNA populations found in differentiation to axenic amastigotes in vitro, to those of the amastigote forms infecting a host cell. (gla.ac.uk)
A switch from glycolysis to mitochondrial respiration drives these cells toward differentiation, but the mechanisms that control this switch are poorly defined. (lww.com)
Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
the gene expression profile during B lymphoid differentiation. (lu.se)
miR-203 drives breast cancer cell differentiation. (medscape.com)

The mechanisms involve the proteins and DNA sequences inside cells. (wikipedia.org)
As these cells with limited functions are inefficient in performing body activities, they are programmed to self demolition under the presence of apoptotic signals, such as caspase proteins and Bcl-2 family regulation proteins. (wikipedia.org)
Invadopodia are cancer cell protrusions rich in structural proteins (e.g. (biorxiv.org)
B ) Levels of SAMHD1, phosphorylated SAMHD1, CDK1 and CDK2 proteins in activated or unstimulated purified CD4+ T cells treated with carrier, AhR agonist or antagonist. (elifesciences.org)
Fluorescently-tagged proteins are ideal reporters for studying the physiological status of living cells. (uni-marburg.de)
Protein diffusion plays a crucial role in determining what function a protein serves within the cell and how, when and where it may physically interact with other proteins and macromolecules in response to external stimuli. (uni-marburg.de)
Here, we analyze the expression signature associated with all 687 RNA-binding proteins (RBPs) and identify 39 that significantly correlate with cell cycle mRNAs. (iric.ca)
Since rate of autophagy in cells was not detected, it is impossible to determine, if there were changes in autophagy that were not reflected as changes in colocalization of these two proteins. (helsinki.fi)
To characterize hCMEC/D3 cells for the presence of specific endocytic pathways, proteins involved into each pathway were selected. (helsinki.fi)
Expression of these proteins at mRNA level was assessed by quantitative real-time polymerase chain reaction (qRT-PCR). (helsinki.fi)
Of the 96 cell lines produced, 91 were hypothetical proteins identified as having transient expression patterns for developmental trajectories drawn over promastigote to metacyclic and axenic amastigote stages. (gla.ac.uk)
Initial assessments by fluorescent microscopy revealed 80 out of the 96 tagged proteins matched overall pseudotime expression profiles, indicating that dynamics of RNA levels detected by scRNA-seq could reflect changes in protein levels. (gla.ac.uk)
Furthermore, these 91 cell lines of tagged hypothetical proteins provide the opportunity for further research into new biology. (gla.ac.uk)
Animal cell technology is an area of rapid expansion and one that produces a wide range of high-value products, including vaccines, recombinant proteins, drugs for cardiovascular, respiratory and immune diseases, and monoclonal antibodies. (imperial.ac.uk)
Independent of light scatter analysis, fluorescence measurements are achieved by transfection and expression of common fluorescent proteins (e.g. (sigmaaldrich.com)
Numerous types of labels can be used to visualize the antibodies for detection in the flow cytometer depending on the experimental design including nucleic acid dyes, cell viability dyes, polymer dyes, quantum dots, small organic molecules, and fluorescent proteins. (sigmaaldrich.com)
Common molecular biology applications include analysis of recombinantly expressed fluorescent proteins that have induced expression in various cell types to elucidate gene function or for in vivo cell tracking. (sigmaaldrich.com)
To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
Both of these altered proteins lead to the eventual ability of cancer cell recurrence. (lu.se)

BCL2 expression increased over BAX expression with increasing malignancy of the tumor from TC to SCLC. (oncotarget.com)
In response to DNA damage, a synthetic lethal relationship exists between the cell cycle checkpoint kinase MK2 and the tumor suppressor p53. (nature.com)
Because BRCA mutations are observed in fewer than 10% of cancer patients (cBioPortal: 6.7%) 11 , 12 , 13 the identification of additional genes that share synthetic lethal sensitivity relationships with mutated oncogenes or tumor suppressors would greatly enhance the implementation of tumor cell-specific synthetic lethal sensitivity to improve an anticancer therapeutic response. (nature.com)
Because most tumors are deficient in one or more aspects of the function of the p53 tumor suppressor, either as a consequence of mutations within p53, or impairment of upstream and downstream modulators of p53 activity 19 , targeting MK2 has the potential to selectively enhance tumor cell killing without increasing the genotoxic effects of chemotherapy on normal p53-wild type tissues. (nature.com)
GSEA analysis found STARD12 and STARD14 were associated with glycolysis, oxidative phosphorylation and tumor related signaling pathways. (medsci.org)
Tumor cell invasion and metastasis require cancer cells to be both proliferative and invasive, i.e. migrate through the tissue and assemble invadopodia. (biorxiv.org)
Metastasis is a complex, multi-step process that is initiated when cancer cells in the primary tumor acquire invasive properties, including motility and the ability to breakdown the extracellular matrix (ECM) 1 , and is responsible for the majority of cancer-related mortalities 2 . (biorxiv.org)
However, under these microenvironmental conditions, only 15% of tumor cells assemble invadopodia at any given time, while the rest are non-motile. (biorxiv.org)
In recent years, cell cycle regulators have been shown to exhibit roles in both tumor suppression and tumor promotion, particularly cyclin-dependent kinase inhibitors (CKI) p27 kip1 and p21 cip1 14 . (biorxiv.org)
In summary, our data highlight MCT4 /SLC16A3 as a key gene for distinct hallmarks of tumor malignancy in glioma cells. (hindawi.com)
This process enables tumor cells, including those within the core of the heterogeneous tumor mass to survive, despite being at a distance from blood vessels that supply their metabolic needs [ 16 , 17 ]. (hindawi.com)
In the metabolic symbiosis model, these cells have been proposed to overexpress MCT4 to release high amounts of lactate produced during anaerobic glycolysis into the tumor microenvironment. (hindawi.com)
We investigated the impact on tumor malignancy in F98 glioma cells using in silico analysis, in vitro cell culture assays, and ex vivo vascular organotypic glioma impact model (VOGIM) [ 35 ] by implanting F98 cells into rat brain slices. (hindawi.com)
Collectively, our data demonstrated that Se increased the expression of tumor suppressor-related genes (IGFBP3, HHIP) and decreased pro-inflammatory gene (CXC L9, HSPB2) expression at cellular nutritional Se dose, even though Caco-2 colon cells were resistant to Se deprivation. (usda.gov)
The aim of the present study was to assess the effects of sprouty homolog 2 (SPRY2) gene regulation by miR-21 on the occurrence, development and tumor metastasis in multiple myeloma (MM). The miR‑21 expression lentiviral vector (LV)‑anti‑miR‑21 and a liposome transfection method were used to screen MM cell lines with stable silent SPRY2. (spandidos-publications.com)
Murphy et al ( 4 ) found that miR-21 is closely associated with the tumor and is able to adjust SPRY2 expression. (spandidos-publications.com)
Here, as part of the International Cancer Genome Consortium/The Cancer Genome Atlas Pan-Cancer Analysis of Whole Genomes Consortium, which aggregated whole-genome sequencing data from 2,658 cancers across 38 tumor types, we performed a multidimensional, integrated characterization of mitochondrial genomes and related RNA sequencing data. (lu.se)
Noninvasive prediction of axillary lymph node breast cancer metastasis using morphometric analysis of nodal tumor microvessels in a contrast-free ultrasound approach. (medscape.com)

We present a computational model for calculating the yield of radiation-induced chromosomal aberrations in human cells based on a stochastic Monte Carlo approach and calibrated using the relative frequencies and distributions of chromosomal aberrations reported in the literature. (bioone.org)
Additionally, the model was used to scale chromosomal exchanges in two or three chromosomes that were obtained from whole-chromosome FISH painting analysis techniques to whole-genome equivalent values. (bioone.org)

The purpose of this study was to determine whether the extended developmental capability of zebrafish top2a mutants arises from maternal expression of top2a or compensation from its top2b paralogue. (whiterose.ac.uk)
Developmental analyses demonstrate abundant expression of maternal top2a but not top2b. (whiterose.ac.uk)
The transcriptomic dynamics underpinning these multifarious developmental transitions through life cycle stages are yet to be fully described. (gla.ac.uk)
Thus, potentially revealing a new developmental strategy for life cycle progression. (gla.ac.uk)
Gene regulation in developmental biology and the cell cycle. (lu.se)
Frontiers in cell and developmental biology. (lu.se)

Analysis of functional categories and signaling and biochemical pathways associated with the response of HeLa cells to treatment with RuT7 showed that it leads the cells through the intrinsic (mitochondrial) apoptotic pathway, via indirect DNA damage due to the action of reactive oxygen species, and through direct DNA binding of RuT7. (ac.rs)
Astrocytes are a heterogeneous population of cells with distinguishing functional and morphological characteristics and are specialized to their different brain regions and locations. (news-medical.net)
This article discusses how a combination of live-cell analysis methods deliver the required flexibility to allow these highly dynamic astrocytic models to be characterized, via quantification of their growth, motility, morphology, and functional analysis. (news-medical.net)
In multiple organs, including the lungs, age-related tissue and organ dysfunction interferes with tissue regeneration, which requires functional stem cells. (karger.com)
Analysis of the profiles specified by two different MAPKs-Fus3p and Kss1p-revealed functional overlap of the filamentous growth and mating responses. (nih.gov)
However, the functional consequences of MCT4 expression on the distinct hallmarks of cancer have not yet been explored at the cellular level. (hindawi.com)
Nephron progenitors, the cell population that give rise to the functional unit of the kidney, are metabolically active and self-renew under glycolytic conditions. (lww.com)
the goal is to cause as little functional squamous cell carcinoma type (HNSCC) and includes and cosmetic damage as possible ( 6 , 9 ). (cdc.gov)
Functional analysis showed that the muscle contraction, immune system/inflammation, and extracellular matrix pathways were the most affected pathways. (cdc.gov)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
In this review, we examine aging as a process dependent on specific changes in molecular pathways within multiple lung cell populations. (karger.com)
Global transcript analysis reflects biological responses associated with the activation and perturbation of signal transduction pathways. (nih.gov)
Characterisation of gene expression patterns in bladder cancer allows the identification of pathways involved in its pathogenesis, and may stimulate the development of novel therapies targeting these pathways. (urotoday.com)
Hypergeometric analysis was used to identify canonical pathways and curated networks having statistically significant enrichment of differentially expressed genes. (urotoday.com)
However it remains unknown which endocytic pathways are active in brain endothelial cells. (helsinki.fi)
As brain endothelial cells are polarized in vivo, the aim of the study was to demonstrate the cell polarization of hCMEC/D3 cells and to study the activity and functionality of different endocytic pathways as a function of cell polarization. (helsinki.fi)
Both metals perturbed gene expression in pathways related to oxidative stress, metabolism, DNA damage, cell cycle, and inflammatory response. (cdc.gov)
Over-expression of COMP leads to activation of Notch which affects both Wnt/β-catenin and AKT pathways, already affected by COMP. (lu.se)

Scope includes mutations and abnormal protein expression. (cancerindex.org)
Protein diffusion in living cells is effectively measured by fluorescence correlation spectroscopy (FCS), a fluctuation-based approach that allows to carry out measurements at a physiological protein expression level. (uni-marburg.de)
In the fluoride-exposed population, the results showed that with the increase in UF content, the expression of miR-4755-5p decreased gradually, while the mRNA transcription and protein expression of Cyclin D1 increased gradually. (fluoridealert.org)
The results demonstrate that fluoride exposure induced the downregulation of miR-4755-5p and downregulated miR-4755-5p promoted fluoride-induced osteoblast activation by increasing Cyclin D1 protein expression. (fluoridealert.org)
Real‑time quantitative polymerase chain reaction (PCR) and western blot analyses were used to detect SPRY2 expression and miR‑21 protein expression levels. (spandidos-publications.com)
Flow cytometry antibodies are used to specifically bind to different cell markers, helping to characterize the cell type and assess any changes in protein expression as part of the experiment. (sigmaaldrich.com)
Wilms' tumour 1 protein expression was measured by Western blotting to determine the anti-leukaemic activity. (bvsalud.org)
In this compiled work, we elaborate on the effect of protein expression alterations and their resulting effect on recurrence capability of cells. (lu.se)

MSCs on PLL-coated plates exhibited a faster growth rate with increased S-phase and upregulated expression of the stemness markers. (hindawi.com)
The aim of this study was to examine whether Annexin A2 and S100A10 expression can be used as prognostic markers for epithelial ovarian cancer (EOC). (cancerindex.org)
The expression of both markers correlated to histological subtype, histological grading, International Federation of Gynecology and Obstetrics (FIGO) stage, and macro-radical surgery. (cancerindex.org)
In this study, using invadopodia- and cell cycle- fluorescent markers, we show in 2D and 3D cell cultures, as well as in vivo , that breast carcinoma cells assemble invadopodia and invade into the surrounding ECM preferentially during the G1 phase of the cell cycle. (biorxiv.org)
A ) FACS analysis of macrophages stained for classical macrophage markers (CD14, CD208) and M1 and M2 macrophage markers (CD80 and CD168, respectively). (elifesciences.org)
With clustering and marker analysis of over 16,500 parasites across three experiments, revealing thousands of stage specific markers. (gla.ac.uk)
This cluster, named here Trans A, displayed overlap between both promastigote and amastigote markers, and potentially representing a new intermediate life cycle stage, defined transcriptionally. (gla.ac.uk)
Furthermore, cell cycle labelling analysis was performed using phase marker orthologues, also revealing new cell cycle phase specific markers. (gla.ac.uk)
Examples of 2-omics analyses include expression quantitative trait locus eQTL (Franke & Jansen, 2009) and methylation quantitative trait locus meQTL (Smith, Kilaru, Kocak, Almli, & Mercer, 2014) that, respectively, assess the influence of genetic and epigenetic markers on gene expression. (researchgate.net)
These evidences are often based on the derivation of standard measures of association, linking (epi-)genetic markers to gene expression combined with gene expression analysis (Wagner, Busche, Ge, Kwan, & Pastinen, 2014). (researchgate.net)
Notably, LCH cells have been found to express markers of both resting epidermal Langerhans cells (CD1a, intracellular major histocompatibility complex II [MHCII], Birbeck granules) and activated Langerhans cells (including CD54 and CD58). (medscape.com)

In this study, we examined the expressions of p33ING1, p14ARF, MDM2 and p21WAF1 mRNA in 25 advanced colorectal cancers by quantitative RT-PCR method, and compared the expression levels of p33ING1, p14ARF, p21WAF1 and MDM2 in relation to p53 status in the tumors. (nih.gov)
Here, we used quantitative real-time PCR, profiling the expression of 93 genes in single-cells from three different cell lines. (frontiersin.org)
Such data are only indirectly related to quantitative changes in cells at different states of division and growth. (frontiersin.org)
D ) Quantitative PCR analysis of late HIV-1 DNA (late reverse transcript (RT)) abundance in macrophages. (elifesciences.org)
A ) Quantitative PCR analysis of CDK1, cyclin A2, CDK2, cyclin E2 and CYP1B1 mRNA levels in macrophages treated with carrier (DMSO), AhR agonist or AhR antagonist. (elifesciences.org)
Protein-protein interactions in living cells are monitored in a quantitative time- and space-resolved fashion by the microscopy-based Förster Resonance Energy Transfer (FRET) approach. (uni-marburg.de)
Quantitative real-time PCR (qRT-PCR) was used to verify the expression of miR-4755-5p. (fluoridealert.org)
Real‑time quantitative PCR and western blot analysis showed that in the MM cell lines with high endogenous miR‑21 expression (RPMI8226 and KM3), SPRY2 expression was significantly lower. (spandidos-publications.com)

Gene-Expression Analysis of Cell-Cycle Regulation Genes in Virus-Infected Rice Leaves. (routledge.com)
PageMan analysis revealed several significantly enriched categories altered by MeJA+NaCl treatment, compared with NaCl treatment alone, including genes involved in secondary metabolism, glutathione-based redox regulation, cell cycle, transcription factors (TFs), and other signal transductions (such as calcium and ROS). (frontiersin.org)
Molecular mechanisms for regulation of gene expression at different levels: remodeling of chromatin, initiation of transcription, nuclear transport and signalling, and RNA interference. (lu.se)
Principles for regulation of gene expression through intercellular signalling. (lu.se)
The tumour microenvironment (TME) contains several other cell types apart from cancer cells which play a role not only in the regulation of the environment but in response to treatments. (lu.se)

Rat primary astrocytes were isolated from different brain regions (cortex, cerebellum, and hippocampus) and grown in vitro to demonstrate the utilization of live-cell analysis for monitoring and comparing the diversity of cultured astroglia phenotypes. (news-medical.net)
However, MSCs need to be expanded in vitro in order to obtain sufficient cells for clinical trials since they are extremely rare in various tissues. (hindawi.com)
Unlike embryonic stem cells, adult stem cells (MSCs) have a limited lifespan and stop proliferating during in vitro culture due to replicative senescence [ 8 ]. (hindawi.com)
Distinct hallmarks of cancer were examined using in silico analysis, various in vitro cell culture assays, and ex vivo organotypic rat brain slice culture model. (hindawi.com)
In present study we characterized human brain endothelial cells, hCMEC/D3, which are widely utilized as BBB in vitro model. (helsinki.fi)

The Incucyte ® Live-Cell Analysis System delivers flexible kinetic quantification of biological phenotypes to monitor growth, motility, morphology, and cellular function. (news-medical.net)
At the cellular level, aging is marked by depletion of adult stem cell reservoirs, the inability to maintain baseline homeostasis, a reduced response to stress, an increased accumulation of damaged DNA leading to telomere shortening, and mitochondrial dysfunction [ 1,2 ]. (karger.com)
Cellular senescence, which is morphologically characterized by an enlarged and flattened cell shape, was first described by Hayflick [ 9 ]. (hindawi.com)
Cellular senescence refers to active cells that eventually enter a state of irreversible growth arrest. (hindawi.com)
Flow cytometry is a laser-based technology that allows the simultaneous measurement of fluorescence in single cells at different wavelengths reporting the cellular concentration of several fluorescently-tagged molecules, and of other physical or biological parameters such as cell size or granularity in a statistically robust fashion. (uni-marburg.de)
Serum in mammalian cell culture media contains trace amount of Se, which is sufficient to maintain cellular selenoprotein such as cellular glutathione peroxidase (c-GPx) expression. (usda.gov)
To understand molecular basis of Se-anticancer effect at cellular nutritional dose (nmol/L), we generated Se-deficient Caco-2 cells with a serum gradual reduction method in the present study. (usda.gov)
The term Langerhans cell histiocytosis is generally preferred to the older term, histiocytosis X. This newer name emphasizes the histogenesis of the condition by specifying the type of lesional cell and removes the connotation of the unknown ("X") because its cellular basis has now been clarified. (medscape.com)
Specifically, a variety of other cellular populations have been identified that possess phenotypic characteristics similar to Langerhans cells, including expression of CD207 and Birbeck granules. (medscape.com)
Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)

Between SCLC and LCNEC CDK2 , CDKN1B , CDKN2A and PNN expression was significantly different with higher expression in SCLC. (oncotarget.com)
Microarray gene expression performed in 251 sarcomas revealed significantly higher expression of TYRO3 and GAS6 in LMS than other sarcomas. (nature.com)
Leiomyosarcoma patients with high expression of GAS6 or PROS1 present a significantly worse PFS. (nature.com)
The number, diversity, and complexity of astroglia cells have increased significantly with evolution, and research from several groups implies that gender differences exist. (news-medical.net)
Cells synchronized in the G0/G1 phase of the cell cycle degrade at significantly higher levels during the first 20 hours post-synchronization release. (biorxiv.org)
In the stratified analysis by cancer types, significantly decreased risk was found in ovarian cancer (AG vs GG: OR = 0.73, 95%CI: 0.53-0.97, P = 0.03). (cancerindex.org)
CD95 counts in the 3 types of white blood cells were significantly higher in PEM infants and showed improvement after nutritional rehabilitation yet not reaching the control values. (who.int)
High-risk MDS cases had a significantly higher percentage of apoptotic CD34+ cells and anti-apoptotic survivin+ cells than controls, particularly for trisomy 8 cases. (who.int)

Integrated analysis of transcriptomics data and DNA methylation data revealed concordant changes in gene expression. (cdc.gov)

In 1868, Paul Langerhans discovered the epidermal dendritic cells that now bear his name. (medscape.com)
Arguments supporting the reactive nature of LCH include the occurrence of spontaneous remissions, the extensive elaboration of multiple cytokines by dendritic cells and T-cells (the so-called cytokine storm) in LCH lesions, and the good survival rate in patients without organ dysfunction. (medscape.com)

The use of real-time, live-cell analysis provides new possibilities and cell biology workflows. (news-medical.net)
5] "Molecular Biology of the cells", B. Alberts et al. (sns.it)
In Systems Genetics , Methods in Molecular Biology 1488:75-120 [An updated primer in using GeneNetwork for molecular analysis of mouse and human cohorts. (genenetwork.org)
Cell cycle gene expression networks discovered using systems biology: Significance in carcinogenesis. (genenetwork.org)
Here, the application of single cell RNA sequencing (scRNA-seq) was employed to investigate the fundamental biology behind transcriptomic changes as the parasite progresses through life cycle stages, from promastigote to metacyclic forms before differentiating into amastigotes. (gla.ac.uk)
This project aimed to provide an example of investigating fundamental Leishmania biology by applying scRNA-seq for the study of life and cell cycle transitions, with the application of pseudotime analysis for the first time. (gla.ac.uk)
Results of differential gene expression analysis revealed new biology not previously described in previous methods. (gla.ac.uk)
In-depth models can be utilised as tools in predictive cell biology. (imperial.ac.uk)
It is clear that the biological behaviour of cells is of such complexity that any model, to be robustly predictive, must be sufficiently structured and detailed in terms of the captured biology. (imperial.ac.uk)
The course is an optional second-cycle course for a degree of Bachelor or Master of Science in Biology and Molecular Biology. (lu.se)

Analysis of the intracellular accumulation of ruthenium showed 8.9 ng Ru/10(6) cells after 6 h of incubation. (ac.rs)
4 Intracellular survival of SL1344 or SL1344 in Organic264.7 cells. (mingsheng88.org)
Autophagy is a pathway for cells to degrade intracellular components that are no longer needed or are detrimental for the cells. (helsinki.fi)
The population balance framework is used to capture cell cycle effects while a single-cell model takes account of some features of intracellular metabolism. (imperial.ac.uk)
View ColorWheel® protocol steps for flow cytometry analysis when using ColorWheel® antibodies with ColorWheel® dyes including antibody preparation, PBMC sample preparation, cell surface staining, and intracellular (cytoplasmic) staining. (sigmaaldrich.com)

We hypothesized that a high fat diet in non-human primates would induce changes in hepatic chromatin structure resulting in altered expression of fetal genes critical to the development of childhood and adult obesity. (nih.gov)

In the present study, cell cycle analysis of HeLa cells treated with RuT7 showed S phase arrest and an increase in sub-G1 population. (ac.rs)
Therefore, compared to normal p53-proficient cells, p53-defective cells are more reliant on MK2 activity, which drives an alternative cell cycle checkpoint pathway that stabilizes the CKI inhibitors p27 Kip1 and Gadd45α in order to maintain G 1 /S and G 2 /M arrest after certain types of DNA damage 16 , 18 . (nature.com)
Flow cytometry analysis showed that both NBT/ATST and TAN/ATST combinations caused significant cell cycle arrest at G0/G1 phase in MDAMB231 cells (ER+). (umass.edu)
From these four compounds, the esterified enantiomer (R)-5a was active in cells, which was evidenced by the increase of p53 levels, the induced expression of p53-target genes (CDKN1A and MDM2), the selective induction of cell cycle arrest, and selective growth inhibition of p53 wt U-2 OS and SJSA-1 compared to p53 del SAOS-2 cells. (rcsb.org)
We explore signalling alterations resulting in cancer stem cells as well as cell cycle arrest and cell fate determination. (lu.se)

These findings establish a mechanism for co-targeting DNA damage-induced cell cycle checkpoints in combination with repair of cisplatin-DNA lesions in vivo using RNAi nanocarriers, and motivate further exploration of ASL as a generalized strategy to improve cancer treatment. (nature.com)
Although CNC exposures are associated with pulmonary inflammation and damage as well as oxidative stress responses and genotoxicity in vivo, studies evaluating cell transformation or tumorigenic potential of CNC's were not previously conducted. (cdc.gov)

The apoptotic potential of the title compound was confirmed with the Annexin V-FITC/PI assay together with a morphological evaluation of cells using fluorescent microscopy. (ac.rs)
To examine differential cancer signaling-gene expression between Se-deficient and Se-supplemented cells, we employed cancer signal pathway-specific array assay as an initial screen. (usda.gov)
The expression of Cyclin D1 protein was detected by enzyme-linked immunosorbent assay (ELISA) and Western blotting, respectively. (fluoridealert.org)
The level of cell polarization in cells grown on transwell permeable supports was characterized at multiple timepoints with four different methods: transepithelial electrical resistance (TEER) measurement, lucifer yellow permeability assay, alkaline phosphatase expression and ZO-1 expression. (helsinki.fi)
A scratch test/wound healing assay was used to detect the cell migration ability. (spandidos-publications.com)
A Transwell assay was used to detect the cell invasion ability. (spandidos-publications.com)

Kaplan Meier plotters were used to evaluate overall survival (OS) and progression-free survival (PFS) in ovarian cancer patients and GEPIA for the differential expression of ESR2 levels in ovarian cancer and adjacent normal tissues. (cancerindex.org)
A 2010 study comparing gene expression of cells expressing CD207 (a marker of Langerhans cells) in LCH lesions with epidermal CD207+ control cells identified differential expression of more than 2000 genes between these 2 subsets. (medscape.com)

Based on our previous miRNA sequence results, bioinformatic analysis was used to predict miR-4755-5p targeting Cyclin D1 . (fluoridealert.org)
Bioinformatic analyses of DNA- and protein sequences. (lu.se)

Multiple myeloma (MM) is a type of malignant plasma cell and has a high incidence in malignant tumors of the blood system, accounting for ~2% of the total mortality of cancer ( 1 ). (spandidos-publications.com)
The working group of the Histiocyte Society divided histocytic disorders into three groups: (1) dendritic cell histiocytosis, (2) macrophage-related disorders, and (3) malignant histiocytosis. (medscape.com)
Breast metastatic tumors in lung can be substituted by lung-derived malignant cells transformed by alternative splicing H19 lncRNA. (medscape.com)

In the adult mammalian subventricular zone (SVZ), GFAP-positive neural stem cells (NSCs) generate neuroblasts that migrate tangentially along the rostral migratory stream (RMS) toward the olfactory bulb (OB). (jneurosci.org)

Stem cells of all organs - including the lung, which harbors distinct stem cells for each separate tissue that makes up the lung as a whole - reside in niches described as a microenvironment that supports and maintains the 'stemness' of cells as a critical reservoir for maintaining tissue homeostasis and responding to injury [ 3 ]. (karger.com)

DEAF-1 activates the expression of Mtk and Drs promoter-luciferase fusion genes in S2 cells. (sdbonline.org)
Methods for analysis of gene expression: microarray, hybridisation, promoter analyses. (lu.se)

Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
Cancer Cell Metabolism: Unique Features Inform New Therapeutic Opportunities. (nyas.org)
Two fundamentals aspects of cell behaviour any model must include are metabolism and the cell cycle. (imperial.ac.uk)
In-depth biological analysis of connected genes in ANDnet and XORnet revealed genes that are related to energy metabolism, cell cycle control (AATF), immune system response, and several cancer types. (researchgate.net)

For cells synthetically endowed with new modules or circuits, measuring their properties via relevant fluorescent reporters helps to characterize the effects of these modifications and to optimize the synthetic constructs. (uni-marburg.de)

Materials and Methods: Sixty representative FFPE-specimens (16 TC, 13 AC, 16 LCNEC and 15 SCLC) were used for mRNA expression analysis using the NanoString technique. (oncotarget.com)
RT-PCR and Western blot analysis were used for determining procollagen I and III mRNA expression and protein production. (thieme-connect.com)
It was also found that visfatin upregulated collagen I and III production, procollagen I and III mRNA expression and protein production. (thieme-connect.com)

HNSCC is the sixth oropharyngeal squamous cell carcinoma (OSCC). (cdc.gov)
Cancer Lett, 300:215-224.doi:10.1016/j. squamous cell carcinoma in north-eastern Iran. (who.int)

Survival analysis showed high STARD12 expression was associated with favorable overall survival, disease special survival as well as disease free survival, while STARD14 showed the opposite. (medsci.org)
Univariate Cox regression analysis showed that Annexin A2 and S100A10 in stromal tissue correlated with shorter overall survival (OS). (cancerindex.org)
Moreover, MCT4 expression is associated with shorter overall survival. (hindawi.com)
The essential role of Se in growth of most mammalian cells is well recognized but certain cancer cells appear to have acquired a survival advantage under conditions of Se-deficiency, and little is known about the role of Se in these cancer cells. (usda.gov)
This observation suggests, for the first time, that Caco-2 colon cancer cells have acquired a survival advantage under Se-deficient culture condition. (usda.gov)
It is essential for cell homeostasis and survival and has been related to various diseases and pathophysiology. (helsinki.fi)

With a few exceptions, most methods integrate more than two different data sources by combining evidences obtained from pairwise analyses (Van Steen & Malats, 2014). (researchgate.net)
The vast amount of heterogeneous omics data, encompassing a broad range of biomolecular information, requires novel methods of analysis, including those that integrate the available levels of information. (researchgate.net)
METHODS: The study used MTT to assess cytotoxicity in leukaemic cells (K562, EoL-1, and KG-1a). (bvsalud.org)
Methods for gene identification and analysis of gene structure: cloning, PCR, restriction mapping, in situ hybridisation, DNA sequencing. (lu.se)

Certain mechanisms are present to prevent cells from indefinite division, which is mostly done by programmed failure in DNA synthesis. (wikipedia.org)
The physiological parameters were detected and a transcriptomic analysis was performed to elucidate the mechanisms underlying MeJA-mediated salt tolerance in alfalfa. (frontiersin.org)
Mechanisms for maintaining genetic information during cell division and the generation of genetic variation: replication, mitosis, meiosis, recombination. (lu.se)
Mechanisms that regulate development from single cell to multicellular organisms. (lu.se)
In this study, we explore mechanisms in breast cancer cells that potentially lead to recurrence. (lu.se)

Temporal monitoring of brain region astroglia revealed differences in cell growth and morphology. (news-medical.net)
Interestingly, there were not detectable differences on cell growth, cell cycle progression between Se-deficient cells and cells supplemented with 500 nmol/L Se in media. (usda.gov)
Hypothesis was to see differences in colocalization of Bcl-2 and Beclin 1 in cells treated with different PREP-modifications and for PREP-inhibition to decrease the colocalization. (helsinki.fi)
Based on previous knowledge, it was expected to see differences in colocalization of Bcl-2 and Beclin 1 in cells treated with different PREP-modifications. (helsinki.fi)
DNA damage assessment and cell cycle analysis revealed differences in the modes of cell death between asbestos and respective CF. There was an increase in chemokines, but not pro-inflammatory cytokines after all EMP treatments. (cdc.gov)

VHL knockout nephron progenitors also exhibit persistent Six2 and Wt1 expression, as well as decreased mitochondrial respiration and prolonged reliance on glycolysis. (lww.com)
Our analysis presents the most definitive mutational landscape of mitochondrial genomes and identifies several hypermutated cases. (lu.se)
Co-expression analysis highlights the function of mitochondrial genes in oxidative phosphorylation, DNA repair and the cell cycle, and shows their connections with clinically actionable genes. (lu.se)

[ 1 ] The 2016 World Health Organization (WHO) classification of lymphoid neoplasms recognizes Burkitt-like lymphoma with 11q aberration as a new provisional entity that lacks MYC rearrangements but resembles Burkitt lymphoma morphologically, to a large extent phenotypically, and by gene expression profiling. (medscape.com)

The molecular processes behind cell cycle progression have been dissected by numerous morphological studies on live or fixed single cells using a plethora of techniques to visualize components and processes during cell division. (frontiersin.org)

Our research programme sets out to integrate modelling, experiment design and validation, and control and optimisation into a single framework that would lead to increased productivity, regulated product quality, and reduced costs for mammalian cell culture systems. (imperial.ac.uk)
The integration of these three research tools represents a unique, novel, and interdisciplinary approach to addressing the complicated research and industrial problem of model-based control and optimisation of mammalian cell culture processes. (imperial.ac.uk)
Mammalian cells are currently the preferred expression system for high-value bio-pharmaceutical products, in particular, monoclonal antibodies. (imperial.ac.uk)
The technique, written into an algorithm, is developed through initial application to a structured model for mammalian cells. (imperial.ac.uk)
Current understanding of mammalian cell cultures lies in the association of their metabolic behaviour to their antibody production output. (imperial.ac.uk)

E6 and Metabolic syndrome and risks of colon and rectal renal cell carcinoma. (who.int)

The Von Hippel-Lindau ( VHL ) tumour suppressor gene undergoes bi-allelic knockout in the vast majority of clear cell RCCs. (springer.com)
The most relevant articles summarising existing knowledge on RCC genomics, including tumour cell evolution and progression, were selected for this review. (springer.com)
As more with the interaction of an agent with a cell, through data become available on precursor events, and as physiological and tissuerorgan changes, resulting in our understanding improves about how chemicals tumour development. (cdc.gov)

These were subjected to whole transcript-based microarray analysis. (urotoday.com)
E ) Microarray analysis of RNA extracted from macrophages treated with AhR agonist or control. (elifesciences.org)
Differentially expressed genes were identified via microarray analysis. (cdc.gov)

Many more investigations have been made on cells, sorted according to size, or artificially arrested at various cell cycle checkpoints. (frontiersin.org)
STARD14 was negatively associated with the infiltration of CD8+T cells, while positively with CCL28 and immune checkpoints, including CTLA4 as well as PD-L2. (medsci.org)

Detailed analysis of cell cycle predictive genes allowed us to define subpopulations with distinct gene expression profiles and to calculate a cell cycle index that illustrates the transition of cells between cell cycle phases. (frontiersin.org)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)

The process also enables cells to proceed to senescence, which are further stages of cell life and growth. (wikipedia.org)
Overexpression of DEAF-1 by using a maternal driver inhibits germ-band retraction and causes defects in dorsal closure, whereas overexpression at later stages causes cell death (Reed, 2008). (sdbonline.org)
Of note during gene marker analysis was the discovery of a transitional cluster placed between promastigote and amastigote stages. (gla.ac.uk)
Analysis indicated the development between promastigote and amastigote stages was possible by progression through this Trans A cluster, circumventing the infective metacyclic form. (gla.ac.uk)
When combined with promastigote stage marker orthologues, a striking overlap between promastigote life stages and cell cycle stages was found, potentially providing further evidence that promastigote morphologies are intrinsically linked with cell cycle stages. (gla.ac.uk)

Flow cytometry techniques were adopted to analyze cell cycle. (thieme-connect.com)
Consequently, SYNMIKRO invested in several devices with different key aspects regarding the analysis of fluorescently-tagged molecules for its Flow Cytometry. (uni-marburg.de)
The distribution of the cell cycle was analyzed by flow cytometry. (fluoridealert.org)
Flow cytometry was used for analysis of cell cycle. (spandidos-publications.com)
Flow cytometry is a technology that uses single or multiple lasers to provide a multi-parametric analysis of single cells. (sigmaaldrich.com)
Need tips on how to improve your flow cytometry analysis? (sigmaaldrich.com)
Performing flow cytometry analysis involves using various flow cytometry antibodies and labels. (sigmaaldrich.com)
Numerous fields of study use flow cytometry and often analyze multiple parameters within diverse populations of cells. (sigmaaldrich.com)

General organization of the eukaryotic cell. (sns.it)

8 Astrocytes interact with blood vessels, pericytes, and epithelial cells to organize CNS flow and modulate the blood-brain barrier (BBB). (news-medical.net)
In this study, we aimed to assess the neoplastic-like transformation potential of two forms of CNC derived from wood (powder and gel) in human pulmonary epithelial cells (BEAS-2B) in comparison to fibrous tremolite (TF), known to induce lung cancer. (cdc.gov)

Visfatin Stimulates Production of Monocyte Chemotactic Protein-1 and Interleukin-6 in Human Vein Umbilical Endothelial Cells. (thieme-connect.com)

Genetic manipulations allowed analysis of changes in gene expression underlying pheromone signaling, cell cycle control, and polarized morphogenesis. (nih.gov)
Our previous work has shown that industrially produced MWCNTs trigger specific changes in gene expression in the lungs of exposed animals. (cdc.gov)

In some cells, such as germ cells, stem cells and white blood cells, the withdrawal process do not occur. (wikipedia.org)
Lung failure due to aging can be traced to loss of lung stem cell regenerative capacity within the distinctive stem cell niches found within each compartment of the lung. (karger.com)
Current knowledge about the identity and function of these stem cell compartments has been largely drawn from a variety of transgenic and spontaneously mutated mouse models that are characterized by rapid rates of aging or have been used to examine regeneration from injury in the context of natural or accelerated aging. (karger.com)
In this review, we will present current data on lung aging and lung regeneration, with specific attention paid to stem cell-driven regeneration within the context of aging. (karger.com)
Stem cells are characterized by their ability to undergo self-renewal to maintain stem cell reserves, and, when required, to produce new, terminally differentiated cells. (karger.com)
During aging, a decline in organ function can be traced to a loss of stem cell function due to increased cell turnover, depletion of stem cells, and alterations to the stem cell niche. (karger.com)
Mesenchymal stem cells (MSCs) possess great therapeutic potential. (hindawi.com)
Although treatment strategies changed from traditional chemotherapy and autologous hematopoietic stem cell transplantation to novel targeted drug therapy, the outcome was not improved ( 2 ). (spandidos-publications.com)
This is consistent with a negative-feedback loop, in which newly generated neurons modulate cell division of SVZ stem cells. (jneurosci.org)
The resulting effect is the rise in stem-like cells within the COMP-overexpressing population, able to propagate further even when in limited quantities. (lu.se)
The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)

Red blood cells, for example, do not contain genetic material when mature, and hence will not carry out cell cycle or its withdrawal. (wikipedia.org)
In this review, we consider what is currently known of the genetic landscape of the commonest subtypes of renal cell cancer (RCC). (springer.com)

[ 3 ] Taken together, these findings have led some to speculate that LCH is not a specific disease of epidermal Langerhans cells, but rather one of mononuclear phagocyte dysregulation. (medscape.com)
There were mineral- and habit-specific patterns of gene expression dysregulation at s.a. equivalent doses. (cdc.gov)

Correction: Expression of hormone receptors is associated with specific immunological profiles of the breast cancer microenvironment. (medscape.com)

immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)

Topoisomerase II alpha is also required for embryonic development in mammals, as mouse Top2a knockouts result in embryonic lethality as early as the 4-8 cell stage. (whiterose.ac.uk)
Inhibition or poisoning of maternal topoisomerase II delays embryonic development by extending the cell cycle M-phase. (whiterose.ac.uk)
Human embryonic kidney cells 293 (HEK-293) and hPREP knockout cell line created from them by using CRISPR/Cas9-silencing were used in the experiments. (helsinki.fi)
By embryonic day 15.5, kidneys of nephron progenitor cell-specific VHL knockout mice begin to exhibit reduced maturation of nephron progenitors. (lww.com)

To validated how transient gene expression changes may be represented at the protein level, 96 fluorescently tagged cell lines were produced using a highthroughput CRISPR-Cas9 system. (gla.ac.uk)

Most studies have been performed on large cell populations, but detailed understanding of cell dynamics and heterogeneity requires single-cell analysis. (frontiersin.org)
While much work has focused on the failure of epithelial cell populations as a key component of the aging process, additional studies have shown that aging, as a global phenomenon in the lung, also impacts resident endothelial, mesenchymal, and immune cell populations. (karger.com)
Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer. (lu.se)

To elucidate whether epigenetic effects play a role for these gene expression changes, we performed whole genome bisulphite sequencing to assess DNA methylation patterns in the lungs 56 days after exposure to MWCNTs. (cdc.gov)
Taken together, the present study revealed that MWCNTs exert epigenetic effects in the lungs of exposed animals, potentially driving the subsequent gene expression changes. (cdc.gov)

cells are activated by interaction with antigens and obtain T indicated that the cell lines representing a defined cell help, they mature into terminally differentiated plasma stage generally presented a high similarity in over- cells secreting large amounts of antibodies [10 -12]. (lu.se)

We previously demonstrated that invasive cells oscillate between two distinct states, termed the Invadopodia state and the Migration state 10 . (biorxiv.org)
The Invadopodia state is characterized by cell stasis and the presence of invadopodia, whereas the Migration state is defined by cell translocation and the absence of invadopodia. (biorxiv.org)
Moreover, MCT4 overexpression enhances cell migration and invasiveness via reorganization of the actin cytoskeleton. (hindawi.com)
The inhibition of cell migration was also analyzed to confirm anticancer progression. (bvsalud.org)
Moreover, ethyl acetate No. 001, morin, and resveratrol effectively inhibited MCF-7 cell migration. (bvsalud.org)
CONCLUSION: Based on these findings, it can be concluded that Kae-Lae has promising chemotherapeutic potential against leukaemic cells, with fractional extracts (ethyl acetate and n-hexane) and resveratrol exhibiting the most potent cytotoxic, antioxidant, anti-inflammatory, and anti-cell migration activities. (bvsalud.org)

This proposal describes a revolutionary biological analysis technology which has the potential to profoundly change the face of clinical medicine and beyond. (nih.gov)
Integration of gene expression and methylation to unravel biological networks in glioblastoma patients: Gadaleta et al. (researchgate.net)

Anatomy27

Organisms12

Diseases12

Chemicals and Drugs108

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes73

Disciplines and Occupations1

Information Science3

Health Care1

Proliferation20

Apoptosis9

Differentiation8

Proteins19

Tumor18

Chromosomal2

Developmental6

Functional9

Pathways9

Protein expression8

Markers11

Quantitative8

Regulation5

Vitro5

Cellular10

Significantly8

Transcriptomics1

Dendritic cells2

Biology10

Intracellular5

Chromatin structure1

Arrest5

Vivo2

Assay6

Differential2

Bioinformatic2

Malignant3

Neural Stem1

Stemness1

Promoter2

Metabolism4

Characterize1

MRNA expression3

Squamous cell carc2

Survival6

Methods4

Mechanisms5

Differences5

Mitochondrial3

20161

Morphological1

Mammalian5

Renal cell carc1

Tumour3

Microarray analysis3

Checkpoints2

Gene expression profiles2

Stages5

Flow cytometry8

Eukaryotic cell1

Epithelial cells2

Endothelial Cells1

Changes in gene expression2

Stem11

Genetic2

Dysregulation2

Microenvironment1

Lymphoid1

Embryonic4

Fluorescently-tagged1

Populations3

Epigenetic2

Terminally differentiated1

Migration6

Biological2