• The cell cycle consists of four phases (G1, S, G2 and M), all of which are characterized by different factors. (news-medical.net)
  • Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. (genome.jp)
  • For a stimulatory signal to reach the nucleus and "turn on" cell division, four main steps must occur. (britannica.com)
  • Third, this activation must stimulate a signal to be transmitted, or transduced, from the receptor at the cell surface to the nucleus within the cell. (britannica.com)
  • In bacteria, which lack a cell nucleus, the cell cycle is divided into the B, C, and D periods. (wikipedia.org)
  • Non-proliferative (non-dividing) cells in multicellular eukaryotes generally enter the quiescent G0 state from G1 and may remain quiescent for long periods of time, possibly indefinitely (as is often the case for neurons). (wikipedia.org)
  • Some orangisms reproduce through the cell cycle and in complex multicellular organisms, the cell cycle is used to allow the organism to grow and to reproduce worn out cells. (mixbook.com)
  • Lee MG, Nurse P (1987) Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2. (springer.com)
  • for example, by allowing identi- fication of rapidly proliferating tumors against which cell cycle-specific agents could be used with maximum effec- tiveness and by allowing rational scheduling of cell cyc- specific therapeutic agents to maximize the therapeutic ratio. (springer.com)
  • Unfortunately, several difficulties have prevented realiza- tion of the early promise of cell cycle analysis: Proliferative patterns of the normal and malignant tissues have been found to be substantially more complex than originally an- ticipated, and synchronization of human tumors has proved remarkably difficult. (springer.com)
  • Human tumors of the same type have proved highly variable, and the cytokinetic tools available for cell cycle analysis have been labor intensive, as well as somewhat subjective and in many cases inapplicable to humans. (springer.com)
  • Cerutti L and Simanis V (2000) Controlling the end of the cell cycle. (els.net)
  • Cell cycle , the ordered sequence of events that occur in a cell in preparation for cell division . (britannica.com)
  • Quantification of the proliferative characteristics of normal and malignant cells has been of interest to oncolo- gists and cancer biologists for almost three decades. (springer.com)
  • The cell cycle is a process in which a cell grows and divides to create a copy of itself. (mixbook.com)
  • The duration of G1 is highly variable, even among different cells of the same species. (wikipedia.org)
  • Yokogawa's high content analysis systems and dual spinning disk confocal technologies provide high-speed and high-resolution live cell imaging, enabling leading-edge research around the world. (yokogawa.com)
  • Initiation of cilium formation occurred normally in morphant kidney duct cells, which implied that the defect lay in elongation. (sciencemag.org)