Cell chronic. Medical search. Frequent questions

S100B single nucleotide polymorphisms exhibit sex-specific associations with chronic pain in sickle cell disease in a largely African-American cohort. (iasp-pain.org)
Pain in sickle cell disease (SCD) is severe and multifaceted resulting in significant differences in its frequency and intensity among individuals. (iasp-pain.org)
Potential risks of chronic sildenafil use for priapism in sickle cell disease. (qxmd.com)
Priapism is a common concern in sickle cell disease. (qxmd.com)
Future studies of sildenafil use in sickle cell disease need to assess the global state of the disease, not just the frequency of priapism. (qxmd.com)
While recovering from a blood and marrow transplant (BMT), this sickle cell disease patient discovered a love of cooking. (choa.org)

The pathological hallmarks of COPD are destruction of the lung parenchyma (pulmonary emphysema), inflammation of the central airways (chronic bronchitis) and inflammation of the peripheral airways (respiratory bronchiolitis). (nih.gov)
CHAPEL HILL - One of the hallmarks of chronic pain is inflammation, and scientists at the UNC School of Medicine have discovered that anti-inflammatory cells called MRC1 + macrophages are dysfunctional in an animal model of neuropathic pain. (wraltechwire.com)
In a new study, published on August 21, 2020 in Science Immunology , an international team of researchers, led by scientists at University of California San Diego School of Medicine, report that the lasting nature of IBD may be due to a type of long-lived immune cell that can provoke persistent, damaging inflammation in the intestinal tract. (scitechdaily.com)
Chang said the findings may help to explain why IBD is chronic and life-long, and point to the possibility of a remedy in the future: Targeting this inflammatory T RM cell subtype for elimination, thus ending the cycle of inflammation and tissue damage. (scitechdaily.com)
Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)
The UCI study, led by Aileen Anderson and Brian Cummings of the Sue and Bill Gross Stem Cell Research Center, is significant because the therapy can restore mobility during the later chronic phase, the period after spinal cord injury in which inflammation has stabilized and recovery has reached a plateau. (uci.edu)
Immunization with vaccines that selectively induced CD4 T cell responses resulted in catastrophic inflammation and mortality after challenge with a persistent strain of LCMV. (northwestern.edu)
Immunopathology required antigen-specific CD4 T cells and was associated with a cytokine storm, generalized inflammation, and multi-organ system failure. (northwestern.edu)
Much of the remainder of the discussion focuses on the different ways in which, in the longer term, the chronic inflammatory process influences maturation, differentiation, and function of effector T cells at sites of inflammation. (biomedcentral.com)
I conclude by speculating about how our understanding of T-cell activation in chronic inflammation may influence future therapy, and discuss this in the context of the prevailing view that in a susceptible host, chronic inflammatory disease occurs through a failure of regulatory T cells to downregulate the inflammatory process. (biomedcentral.com)

A low dose (approximately 1.5×10(5) cells per kilogram of body weight) of autologous chimeric antigen receptor-modified T cells reinfused into a patient with refractory chronic lymphocytic leukemia (CLL) expanded to a level that was more than 1000 times as high as the initial engraftment level in vivo, with delayed development of the tumor lysis syndrome and with complete remission. (nih.gov)

In this study, we examined the influence of S100B gene single nucleotide polymorphisms (SNP) on acute and chronic pain variability in SCD. (iasp-pain.org)
We applied a range of molecular and cellular techniques to measure cell survival, cell cycle progression, protein expression and DNA damage combined with a transcriptomic micro-array approach in D283-MED cells, for global gene expression analysis in acute and chronic hypoxic conditions. (biomedcentral.com)
LONDON, July 11, 2023 --( BUSINESS WIRE )-- Clinisupplies , a leading manufacturer and supplier of continence care consumables, today announced the acquisition of Great Bear Healthcare , a UK-based manufacturer and supplier of continence products for managing acute and chronic conditions. (yahoo.com)
Clinisupplies is a leading UK-based manufacturer and supplier of medical appliances specialising in continence products for managing acute and chronic conditions. (yahoo.com)

One study , which was led by Georg M. Lauer, MD, PhD, of the Division of Gastroenterology at MGH, focused on differences between memory and exhausted T cells in individuals with human hepatitis C virus (HCV) infection before and after treatment. (massgeneral.org)
We are currently studying whether treating HCV with direct acting antiviral therapy in the acute phase of infection, instead of many years later, will result in full memory differentiation of T cells. (massgeneral.org)
A complementary study in the same issue of Nature Immunology that was led by Debattama Sen, PhD, at the Center for Cancer Research at MGH, and W. Nicholas Haining, BM, BCh, at Merck found that these exhausted T cells in chronic HCV infection were regulated epigenetically, or through physical changes in the cells' chromosomes that affect the expression of genes. (massgeneral.org)
These scars might be locking the exhausted T cells and preventing return to proper function even if the chronic infection in the patient is cured," notes Sen. "Thus, restoring the function of these cells will likely require directly removing or inactivating these scarred regions to unlock the cells' functionality. (massgeneral.org)
Chronic persistence of the adult worm infection can be modified by use of a synthetic TGF -beta type 1 receptor inhibitor in vivo. (cam.ac.uk)
I am interested in the mechanisms underlying this Foxp3+ regulatory T cell expansion in vivo and have focused on whether antigen presenting cells such as dendritic cells are re-programmed to a tolerogenic, regulatory T cell inducing, phenotype following infection. (cam.ac.uk)
I have found that chronic helminth infection is associated with the expansion of CD11c(lo) dendritic cells in the draining lymph nodes of the gut. (cam.ac.uk)
My research is now focusing on manipulating plasmacytoid dendritic cell populations in vivo and determining the cause for the changes in the CDllc(lo) and Foxp3+ T cell populations following infection. (cam.ac.uk)
In an attempt to control infection, masses of neutrophils and other immune cells continue to gather at the site of infection, forming large groups of these cells called granulomas, hence the name of the disease. (primaryimmune.org)
In most cases, CD8 + T cells quickly recognize and destroy infected cells to prevent the infection from spreading. (futurity.org)
When it comes to viruses that lead to chronic infection, immune cells receive the wrong set of marching orders, which makes them less responsive," says Martin Richer, an assistant professor in the microbiology & immunology department at McGill University and senior author of a study outlining the findings, which appears in Immunity . (futurity.org)
That maneuver buys time for the pathogen to outpace the immune response and establish a chronic infection. (futurity.org)
Importantly, this pathway can be targeted to restore some functionality to the T cells and enhance the capacity to control infection. (futurity.org)
We previously demonstrated long-lived immunoreactivity in individuals with past symptomatic and asymptomatic Coxiella infection (convalescents) to promiscuous HLA-class II C. burnetii epitopes, providing the basis for a novel T-cell-targeted subunit vaccine. (biorxiv.org)
Here we investigated in a cohort of 22 individuals with persistent infection (chronic Q fever) whether they recognize the same set of epitopes, or distinct epitopes that could be candidates for a therapeutic vaccine or aid in the diagnosis of persistent infection. (biorxiv.org)
Untreated Lyme Disease causes a lot of awful chronic problems , however a round or two of antibiotics is generally enough to treat the infection. (stackexchange.com)
When an infection has been conquered, the immune system leaves behind long-lasting cells called memory T cells, which reside in tissues or circulate through the body remembering past pathogens, ever ready to sound the alarm should specific invaders reappear. (scitechdaily.com)
Background & Aims: During chronic HCV infection, T cell dependent virus-specific antibodies are produced. (eur.nl)
Conclusions: The specific localization of TFH cells and IgG and IgD/IgM-producing B cells suggests a functional B-T cell environment in liver follicles during HCV infection. (eur.nl)
Lentiviral vector-based dendritic cell vaccines induce protective T cell responses against viral infection and cancer in animal models. (jci.org)
Injection of a lentiviral vector encoding an MHC class I-restricted T cell epitope of lymphocytic choriomeningitis virus (LCMV) and CD40 ligand induced an antigen-specific cytolytic CD8 + T lymphocyte response that protected the mice from infection. (jci.org)
We evaluated whether induction of virus-specific CD4 T cells by vaccination would protect mice against infection with chronic lymphocytic choriomeningitis virus (LCMV). (northwestern.edu)
Innate adaptive immune cell dynamics in tonsillar tissues during chronic SIV infection. (bvsalud.org)
HIV -infected patients are at higher risk of developing oral mucosal infection and Epstein-Barr virus ( EBV )-associated B cell malignancies . (bvsalud.org)
In this study, we investigated the changes of innate and adaptive immune cells in macaque tonsils during chronic SIV infection . (bvsalud.org)
We further confirmed a recently described small B-cell subset , NKB cells , were higher during chronic infection . (bvsalud.org)
A dramatic reduction of IFN-Î³ production by innate immune cells might indicate enhanced susceptibility to EBV infection and potential transformation of B cells in the tonsils . (bvsalud.org)
Our data extends our understanding of the oral innate immune system during SIV infection and could aid future studies in evaluating the role of tonsillar immune cells during HIV -associated oral mucosal infections . (bvsalud.org)
A low white blood cell count may make a person more likely to contract an infection. (medicalnewstoday.com)
White blood cells help fight infection in the body. (medicalnewstoday.com)
A person may experience a short-term drop in their white blood cell count due to infection, drug interaction, or other causes. (medicalnewstoday.com)

Chronic granulomatous disease (CGD) is a type of primary immunodeficiency (PI) in which one group of the body's white blood cells, called neutrophils, fail to make the hydrogen peroxide, bleach, and other chemicals needed to fight bacterial and fungal infections. (primaryimmune.org)
Alveolar walls and pulmonary arteries were examined with immunohistochemical methods to identify neutrophils, eosinophils, mast cells, macrophages, and CD4 + ve and CD8 + ve cells. (atsjournals.org)
Neutrophils account for 55-70% of all white blood cells. (medicalnewstoday.com)
[17] Less commonly, the disease comes to light only after the cancerous cells overwhelm the bone marrow, resulting in low red blood cells, neutrophils, or platelets. (wikipedia.org)
Treatment with the anti-AREG antibody prevented resolution of DE exposure-induced airway influx of total cells, neutrophils, and macrophages and increased levels of TNF-a, IL-6, and CXCL1. (cdc.gov)

By comparing T cell responses across a range of viruses that are either effectively cleared (like influenza) or become chronic (like HCV and HIV), the scientists produced a map of where these exhaustion-specific scars occur. (massgeneral.org)
Overexpression of SLAMF1 or SLAMF7 in IGHV mutated CLL cell models resulted in reduced proliferation and impaired responses to BCR ligation, whereas the knockout of both receptors showed opposing effects and increased sensitivity toward inhibition of components of the BCR pathway. (nature.com)
They are known to be involved in the regulation of NK and T cell responses, mostly by homotypic interactions except for SLAMF2 (CD48) and SLAMF4 that interact with each other [ 10 ]. (nature.com)
Most notably, some gut helminths can also downregulate T cell responses to inflammatory stimuli including asthmatic and allergic reactions through stimulation and expansion of Foxp3+ regulatory T cells. (cam.ac.uk)
Individuals with chronic Q fever showed strong class II epitope-specific cultured ELISpot responses largely overlapping with the peptide repertoire identified previously for convalescents. (biorxiv.org)
Consistent with more recent/prolonged exposure, we found, however, stronger direct ex vivo responses to whole-cell C. burnetii and individual peptides in direct ELISpot than in convalescents. (biorxiv.org)
In vitro cell culture and animal studies have demonstrated that mesenchymal stromal cells (MSCs) have the capacity to modify immune responses and to enhance tissue repair. (bmj.com)
Previous studies in other labs had uncovered certain sex differences in the response to stress, but those findings were obtained using research methods that could mask significant differences in the responses of specific cells or even entirely erase the roles played by relatively rare cells. (anxiety-stress-management.com)
Data regarding the imbalance in follicular helper T (Tfh) and follicular regulatory T (Tfr) cell responses in patients having chronic rhinosinusitis with nasal polyps (CRSwNP) is so far limited. (tinnitusjournal.com)
CD4 T cells promote innate and adaptive immune responses, but how vaccine-elicited CD4 T cells contribute to immune protection remains unclear. (northwestern.edu)
These data demonstrate that vaccine-elicited CD4 T cells in the absence of effective antiviral immune responses can trigger lethal immunopathology. (northwestern.edu)
However, the unusual phenotype of synovial T cells, including their profound proliferative hyporesponsiveness to TCR ligation, has challenged the notion that T-cell effector responses are driven by cognate cartilage antigens in inflamed synovial joints. (biomedcentral.com)
On the basis of these data, it is proposed that T-cell survival and effector responses are driven by antigen-independent, cytokine-dependent mechanisms, and that therapeutic strategies that seek to restore T-cell homeostasis rather than further depress T-cell function should be explored in the future. (biomedcentral.com)
This chapter aims to explore this theme in more depth, beginning with an outline of the molecular events that dictate the differentiation of T helper (Th) cells at the outset of adaptive immune responses in regional lymph nodes. (biomedcentral.com)

This includes analysis of CLL samples at various times during the disease course, during microenvironment-targeting therapies, and comparison of CLL cells in lymph nodes and peripheral blood. (europa.eu)
We aim to reveal how the malignant B cells change the propensity of their signalling pathways in response to the different microenvironments such as peripheral blood vs lymph node to obtain the proliferative signals. (europa.eu)
Altogether, these data indicate that the epigenome of CLL cells from the peripheral blood change dynamically in response to stimuli and suggest that these cells might adapt to the Ibrutinib "hit" in a process leading toward a possible reduced sensitivity to treatment. (whiterose.ac.uk)
Two milliliters of peripheral blood samples were collected from all participants into EDTA-containing vacutainer tubes to assess the levels of Tfh and Tfr cells using flow cytometry. (tinnitusjournal.com)
We investigated the function of TFH cells and B cells in liver and in peripheral blood of chronic HCV patients. (eur.nl)
The hierarchy of T-cell dysfunction from peripheral blood to inflamed joint suggests that these defects are acquired through prolonged exposure to proinflammatory cytokines such as tumour necrosis factor (TNF)-α. (biomedcentral.com)

Two new studies led by investigators at Massachusetts General Hospital (MGH) and published in Nature Immunology provide insights into T cell exhaustion, which could lead to potential strategies to overcome it. (massgeneral.org)

At the Aflac Cancer and Blood Disorders Center, we provide long-term, specialized care to children and teens who have been diagnosed with chronic graft-versus-host disease (GVHD) as a result of a blood and marrow transplant (BMT). (choa.org)
Chronic graft-versus-host disease (GVHD) can occur in children who have received a BMT for their cancer or blood disorder diagnosis. (choa.org)

The research reveals that certain viruses persist by driving the production of a cytokine that leads to modification of glycoproteins on the surface of the CD8 + T cells, making the cells less functional. (futurity.org)
To identify regulators of primitive chronic myeloid leukemia (CML) cells, we performed a high-content cytokine screen using primary CD34 + CD38 low chronic phase CML cells. (haematologica.org)
2 1 There is growing evidence to suggest that primitive CML cells affect the bone marrow (BM) niche, contributing to deregulated cytokine levels. (haematologica.org)
Cytokines are essential for the function and maintenance of cells, and altered cytokine levels influence not only leukemic cells, but also the normal HSC within the BM. (haematologica.org)
The DCs are then pulsed with synthetic peptide or cell lysate and matured with cytokine or TLR agonists. (jci.org)
Indeed, there are now compelling data to suggest that chronic cytokine activation may contribute substantially to the phenotype and effector function of synovial T cells. (biomedcentral.com)
For cytokine genes, at least three stages are thought to be required for the acquisition of transcriptional competence in T cells: an initiation phase, a commitment phase, and a phase of acute gene transcription (Fig. 1 ). (biomedcentral.com)
AREG intranasal treatment for 3 days during recovery phase reduced repetitive DE-induced airway inflammatory cell influx and cytokine release. (cdc.gov)

AVM induced the release of cleaved PARP and cleaved caspase‑3 caused apoptosis and inhibited the viability of these cells. (spandidos-publications.com)
Therefore, in healthy individuals self-immunogenic T cells are targeted for apoptosis, while those yielding mild affinity to the MHC are released into the periphery for circulation ( 5 ). (biorxiv.org)
Chronic myeloid leukemia (CML) results from BCR-ABL oncogene, which blocks CML cells differentiation and protects these cells from apoptosis. (jcancer.org)
Here, we determined the effect of Jiyuan oridonin A (JOA), an ent -kaurene diterpenoid compound, on the differentiation blockade in imatinib-sensitive, particularly, imatinib-resistant CML cells with BCR-ABL-T315I mutation by cell proliferation assay, apoptosis analysis, cell differentiation analysis, cell cycle analysis and colony formation assay. (jcancer.org)

A clinical trial to evaluate the safety and efficacy of a stem cell product injected directly into the brain to treat chronic motor deficits from ischemic stroke has begun at McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth). (news-medical.net)
Dr. Charles S. Theofilos is a board-certified neurosurgeon and founder of The Spine Center, and he says that in some cases doctors can already use a patient's own stem cells to treat chronic pain . (worldnewsstand.net)
Does Infusio's approach, based in part on stem cell therapy, treat chronic Lyme Disease? (stackexchange.com)

The mutations causes white blood cells (lymphocytes, macrophages, and eosinophils) to move towards dendritic cells, resulting in damage in any organ except the heart and kidneys. (wikipedia.org)
Macrophages are a type of immune cell that are found in the blood and in tissues throughout the body. (wraltechwire.com)
But neuropathic pain appears to disable these macrophages and prevent them from doing their job," said senior author Mark Zylka, PhD, director of the UNC Neuroscience Center and Kenan Distinguished Professor of Cell Biology and Physiology. (wraltechwire.com)
From those experiments, the researchers found a population of anti-inflammatory cells called MRC1 + macrophages that were dysfunctional. (wraltechwire.com)
With the identity of the cells revealed, Zylka's lab delivered a gene therapy designed to stimulate the expression of an anti-inflammatory protein called CD163 in MRC1 + macrophages. (wraltechwire.com)

We designed a lentiviral vector expressing a chimeric antigen receptor with specificity for the B-cell antigen CD19, coupled with CD137 (a costimulatory receptor in T cells [4-1BB]) and CD3-zeta (a signal-transduction component of the T-cell antigen receptor) signaling domains. (nih.gov)
Apart from the tumor lysis syndrome, the only other grade 3/4 toxic effect related to chimeric antigen receptor T cells was lymphopenia. (nih.gov)
Engineered cells persisted at high levels for 6 months in the blood and bone marrow and continued to express the chimeric antigen receptor. (nih.gov)
We identified a subset of Chronic Lymphocytic Leukemia (CLL) patients with high Signaling Lymphocytic Activation Molecule Family (SLAMF) receptor-related signaling that showed an indolent clinical course. (nature.com)
Since the SLAMF low signature was strongly associated with an unmutated CLL immunoglobulin heavy chain (IGHV) status in large datasets, we investigated the impact of SLAMF1 and SLAMF7 on the B cell receptor (BCR) signaling axis. (nature.com)
B cell receptor (BCR) signaling plays a critical role in driving proliferation and survival of the malignant clone in chronic lymphocytic leukemia (CLL), supported by the clinical activity of inhibitors targeted toward BCR-associated kinases [ 1 ]. (nature.com)
These regulatory T cell changes could be inhibited with excess antigen or the retinoic acid receptor antagonist LE540 and are enhanced with recombinant TGF -beta. (cam.ac.uk)
A critical component in CLL pathogenesis is the activation of the B-cell receptor signalling taking place in lymph nodes, and in the context of other microenvironmental interactions (such as CLL-T cell interaction). (europa.eu)
The obtained data led us to hypothesize on the mechanisms of regulation of signalling propensity of two pathways that are responsible for proliferation and survival of CLL cells, namely B Cell Receptor (BCR) signalling and signals from T-cells mediated by CD40/IL4. (europa.eu)
The T-cell repertoire derives this high diversity through somatic recombination of the T-cell receptor (TCR) locus, a random process that results in repertoires that are largely private to each individual. (biorxiv.org)
Led by co-senior authors John T. Chang, MD, professor of medicine, and Gene W. Yeo, Ph.D., professor of cellular and molecular medicine, the research team performed mRNA and antigen receptor sequencing from immune cells isolated from samples taken from rectal biopsies or blood of IBD patients and healthy controls. (scitechdaily.com)
We took advantage of a state-of-the-art approach allowing us to generate mRNA and antigen receptor sequencing data from the same single cells," said Yeo, "and analyzed thousands of individual cells, which is quite exciting. (scitechdaily.com)
Although recently introduced small-molecule B-cell receptor signalling inhibitors have revolutionized CLL treatment, data for ibrutinib still point to impaired prognosis for TP53-affected patients. (muni.cz)

COPD (chronic obstructive pulmonary disease) is a treatable and preventable disease state, characterized by progressive airflow limitation that is not fully reversible. (nih.gov)
Mesenchymal stromal cells: a novel therapy for the treatment of chronic obstructive pulmonary disease? (bmj.com)
Previous studies have shown an increased number of inflammatory cells and, in particular, CD8 + ve cells in the airways of smokers with chronic obstructive pulmonary disease (COPD). (atsjournals.org)

Chronic granulomatous disease (CGD) is an inherited disease in which the body's cells that eat invaders (also called phagocytes) do not make hydrogen peroxide and other chemicals. (primaryimmune.org)
Individuals with chronic granulomatous disease (CGD) are usually healthy at birth. (primaryimmune.org)
Patient 1 was a 14-year-old boy with p47 phox -deficient chronic granulomatous disease. (cdc.gov)

One of these T RM cell subtypes was distinguished by high levels of the transcription factor Eomesodermin and programmed to produce large amounts of cytokines and other molecules to kill newly detected infected cells. (scitechdaily.com)
Aberrantly expressed cytokines in the bone marrow (BM) niche are increasingly recognized as critical mediators of survival and expansion of leukemic stem cells. (haematologica.org)
Out of the 313 unique human cytokines evaluated, 11 were found to expand cell numbers ≥2-fold in a 7-day culture. (haematologica.org)
Natural-killer (NK) cells are specialized lymphocytes that have cytotoxic properties in addition to their ability to produce cytokines that assist in the orchestration of adaptive immunity. (medscape.com)

The focus of the present review is directed towards the role of CD8(+) T-lymphocytes, NK (natural killer) cells and NKT cells (NK T-cells). (nih.gov)
The adaptive immune system consists of 2 types of lymphocytes: T cells (70-75% of the adaptive immune force) and B cells (10-20% of the adaptive immune force). (medscape.com)
Chronic lymphocytic leukemia ( CLL ) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). (wikipedia.org)
[4] [9] CLL results in the buildup of B cell lymphocytes in the bone marrow, lymph nodes, and blood . (wikipedia.org)
Diagnosis is typically based on blood tests finding high numbers of mature lymphocytes and smudge cells. (wikipedia.org)
Most people are diagnosed as having CLL based on the result of a routine blood test that shows a high white blood cell count, specifically a large increase in the number of circulating lymphocytes . (wikipedia.org)

BOSTON - Chronic viral infections and cancer can cause "killer" T cells in the immune system to take on a state of dysfunction or exhaustion whereby they can no longer react to infectious invaders or abnormal cells like normal "memory" T cells. (massgeneral.org)
We might be able to take advantage of the pathways induced by these signals to fight chronic viral infections by making the immune system more responsive. (futurity.org)
CD4+CXCR5+ T follicular helper (TFH)-cells activate B cells and are important for clearance of various chronic viral infections. (eur.nl)

These GCs host highly diversified clones that are subjected to mild selection forces, demonstrating that clonal diversification can be uncoupled from clonal selection in chronic GCs. (lu.se)
Consistent with this hypothesis, we find that increased age is correlated with decreased overall TCRβ clone sharing, indicating that the pattern of private TCRβ clonal expansion is a general feature of the T-cell response to other infectious antigens. (biorxiv.org)
1 The BCR-ABL1 fusion protein is a constitutively active tyrosine kinase and triggers a cascade of aberrant downstream signaling pathways leading to clonal outgrowth of CML cells and subsequent disease manifestation. (haematologica.org)
Chronic myeloid leukemia (CML) is a clonal expansion of the progenitor hematopoietic stem cells arising from the existence of the fusion BCR-ABL oncogene, that represents 15%-20% of the newly diagnosed cases of leukemia patients [ 1 - 2 ]. (jcancer.org)

Successful treatment of therapy-resistant chronic leukemia using allogeneic stem cell transplantation. (disabled-world.com)
The German CLL Study Group proved this in a multi-centric clinical phase II study led by Professor Dr. Peter Dreger, senior consultant and head of the division of stem cell transplantation at the Department of Internal Medicine V at Heidelberg University Hospital. (disabled-world.com)
Our study is the largest so far for this patient population and proved that allogeneic stem cell transplantation is a promising therapy option for high-risk CLL and has the potential to cure for this otherwise incurable kind of leukemia," says Professor Dreger, head of the study. (disabled-world.com)
Allogeneic stem cell transplantation is a very stressful and risky form of therapy, which could previously not be carried out on the generally older patients affected by CLL. (disabled-world.com)
Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the GCLLSG CLL3X Trial. (disabled-world.com)
In the double-blind, sham-surgery controlled study, patients randomized to the study intervention will receive a stem cell product made by SanBio and patients must have chronic motor deficits from an ischemic stroke to be eligible for the study. (news-medical.net)
Results of a phase 1/2A study of the stem cell product, presented at the International Society of Stem Cell Research Meeting and published in the journal, Stroke , showed statistically significant improvements in motor function and no safety concerns. (news-medical.net)
But some stem cell treatments have been known to cause tumors, which is why the team wanted to ensure that their therapy was free of any negative side effects. (medicalxpress.com)
D., director and professor of the Center for Stem Cell and Regenerative Medicine (CSCRM) at Tokyo Medical and Dental University. (medicalxpress.com)
Lymphoscintigraphy for the Assessment of Autologous Stem Cell Implantation in Chronic Lymphedema. (stembook.org)
The new research on regenerative stem cell treatments to heal bone fractures was published online in Molecular Therapy, a peer-reviewed journal in the Nature Publishing Group. (worldnewsstand.net)
The article, written by researchers from the Skeletal Regeneration and Stem Cell Therapy Program in the Department of Surgery and Cedars-Sinai Board of Governors Regenerative Medicine Institute, was accepted and published in a preview form online on Nov. 20, 2015, and will appear in a 2016 version of the journal. (worldnewsstand.net)
Less intensive forms of treatment are usually recommended before surgery or regenerative stem cell treatments, but even so, Dr. Theofilos believes regenerative medicine is a "game-changer" in the health industry. (worldnewsstand.net)
Between 2008 and 2012 alone, stem cell research grew considerably at more than double the rate of other research studies that took place during that time. (worldnewsstand.net)
Is stem cell therapy effective against chronic Lyme Disease? (stackexchange.com)
Stem cell therapy may be effective in treating Lyme disease, however the safety and efficacy of such treatments in currently unproven due to how recent they are. (stackexchange.com)
In at least one case report, stem cell therapy was effective at treating long-term complications from untreated Lyme Disease. (stackexchange.com)
However, the results of this and other case reports have only recently become available for study, and stem cell therapy doesn't appear to have comprehensive studies proving safety and efficacy. (stackexchange.com)
Because of this, Infusio's claims should be taken with a large amount of suspicion, and their stem cell treatment plan may not be as effective as they are claiming. (stackexchange.com)
As this paper demonstrates, questionable medical providers advertise various treatments for both normal and Chronic Lyme Disease, including stem cell therapy. (stackexchange.com)
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by an acquired 9;22-chromosomal translocation in a hematopoietic stem cell (HSC) resulting in the expression of the BCR-ABL1 fusion protein. (haematologica.org)
Previous breakthrough stem cell studies have focused on the acute, or early, phase of spinal cord injury, a period of up to a few weeks after the initial trauma when drug treatments can lead to some functional recovery. (uci.edu)
StemCells Inc., based in Palo Alto, Calif., is engaged in the research, development and commercialization of stem cell therapeutics and tools for use in stem cell-based research and drug discovery. (uci.edu)
Promoting basic and clinical research and training in the field of stem cell biology at UC Irvine, the center is a leading international institution in stem cell research and clinical applications. (uci.edu)
The center provides an organizational structure for all areas of stem cell research, supports premier graduate training, maintains a core stem cell facility and equipment, hosts guest researchers and annual meetings, and contributes to research and dialogue on policy and ethical issues related to stem cells. (uci.edu)

Interestingly, AVM appeared to be more sensitive to imatinib‑resistant (T315I, Y253H, and E279K) than wild‑type BCR/ABL cells, indicating its potential to overcome imatinib‑resistant severe issues in CML. (spandidos-publications.com)

The destructive changes and tissue remodelling observed in COPD are a result of complex interactions between cells of the innate and adaptive immune systems. (nih.gov)
Following early observations that MSCs inhibit T-cell proliferation, 9 MSCs were found to interact with the majority of innate and adaptive immune cells. (bmj.com)
Innate immunity resides in the skin, mucous membranes, polymorphonuclear (PMN) cells, complement system, and a select group of cells that possess cytotoxic capabilities. (medscape.com)
NK cells are specialized effectors of the innate immune system that destroy their targets by antibody-dependent cell-mediated cytotoxicity, have prominent antitumor effects, and are potent killers of virally infected cells. (medscape.com)
Other cellular components of the innate immune system include mononuclear phagocytes, dendritic cells, and NK cells. (medscape.com)
Furthermore, both adaptive and innate cells showed significantly higher TNF-α and cytotoxic marker CD107a, while IL-22 production was significantly reduced in innate and adaptive immune cells in chronic SIV-infected animals . (bvsalud.org)

Vaccination by direct injection of lentiviral vector was more effective in sterile alpha motif and HD-domain containing protein 1-knockout (SAMHD1-knockout) mice, suggesting that lentiviral vectors containing Vpx, a lentiviral protein that increases the efficiency of dendritic cell transduction by inducing the degradation of SAMHD1, would be an effective strategy for the treatment of chronic disease in humans. (jci.org)
This monograph only gives information about ofatumumab injection (Arzerra) for treatment of chronic lymphocytic leukemia. (medlineplus.gov)

It is now known as chronic multifocal Langerhans cell histiocytosis, a subtype of LCH. (wikipedia.org)
We found that this inflammatory T RM cell subtype seemed to be enriched in the intestinal tissues of patients with ulcerative colitis, a form of IBD that affects the colon," said Chang. (scitechdaily.com)
The researchers also found evidence that this inflammatory T RM cell subtype might not remain confined to intestinal tissue, but may also escape into the bloodstream. (scitechdaily.com)
The most significant difference was found in a type of brain cell called the oligodendrocyte - a subtype of glial cell that provides support to nerve cells and plays an important role in regulating brain activity. (anxiety-stress-management.com)
[18] CLLs are, in virtually all cases, preceded by a particular subtype of monoclonal B-cell lymphocytosis (MBL). (wikipedia.org)

This study highlights the ability of a patient's own stem cells to potentially heal torn cartilage in the knee," said Anthony Atala, M.D., Editor-in-Chief of STEM CELLS Translational Medicine and director of the Wake Forest Institute for Regenerative Medicine. (medicalxpress.com)

A specific immune response was detected in the bone marrow, accompanied by loss of normal B cells and leukemia cells that express CD19. (nih.gov)
2 MSCs were first described in the bone marrow where they constitute a small fraction of cells (0.001%-0.01%) that closely interact with haematopoietic cells to support haematopoiesis and skeletal homeostasis. (bmj.com)
MSCs are multipotent adult stem cells present in the umbilical cord, bone marrow, fat, dental and other body tissues. (medicalxpress.com)
Chronic myeloid leukemia (CML) is a malignancy of the blood and bone marrow that affects children and adults. (spandidos-publications.com)
The researchers used a combination of mesenchymal stem cells, taken from the bone marrow of adults, and parathyroid hormone, or PTH, which regulates calcium levels in human bones. (worldnewsstand.net)
The study found that the combination therapy "significantly enhanced the stem cells' migration to the area of the bone fracture and increased the formation of new, healthy bone," reports OrthoSpineNews. (worldnewsstand.net)
Researchers explained that although PTH and stem cells can work well separately to heal bone fractures, their effects were much stronger when combined. (worldnewsstand.net)
Stem cells are currently utilized in a number of treatments around the world to treat and manage conditions such as diabetes, heart failure, and degenerative bone and joint conditions that cause chronic pain. (worldnewsstand.net)
The team is currently assessing whether seeding these dermal grafts with allogeneic human dermal fibroblasts or bone marrow stromal cells will enhance PrU healing. (orthopaedic-institute.org)
White blood cells form in the bone marrow and are critical for the immune system. (medicalnewstoday.com)
Leukemia cells can force out the cells in the bone marrow that make normal blood cells. (medicalnewstoday.com)
[18] Whereas, with CLL, diseased cells propagate from within the bone marrow, in SLL they propagate from within the lymphatic tissue. (wikipedia.org)

The transplantation of stem cells from a healthy donor (allogeneic) offers the chance of cure for patients with an aggressive form of chronic lymphocytic leukemia (CLL), irrespective of genetic prognostic factors and the prior course of the disease. (disabled-world.com)
Any problems that might arise in the case of allogeneic cells, which are donated by someone other than the patient, still need to be determined. (medicalxpress.com)

A pro-inflammatory environment is thought to provide a selective advantage for the leukemic stem cells (LSC). (haematologica.org)
Other inflammatory cells were no different among the three groups. (atsjournals.org)
Indeed, a localization of inflammatory cells within the alveolar walls might contribute to smoking-induced parenchymal destruction and the subsequent chronic airflow limitation ( 3 ). (atsjournals.org)
Indeed, inflammatory cells might cause structural changes in pulmonary arteries of smokers ( 16-18 ) and contribute to the development of pulmonary hypertension present in severe COPD ( 19 , 20 ). (atsjournals.org)
The strong association between specific alleles encoded within the MHC class II region and the development of rheumatoid arthritis (RA) has provided the best evidence to date that CD4 + T cells play a role in the pathogenesis of this chronic inflammatory disease. (biomedcentral.com)
This paradigm proposes that genetic and environmental factors shape a complex series of molecular and cellular interactions leading to a chronic inflammatory response. (biomedcentral.com)
Precisely how effector T cells initiate and promote the inflammatory process in RA, however, remains far from clear. (biomedcentral.com)
However, the results of detailed phenotypic and functional analyses of chronically activated T cells derived from inflamed joints are difficult to reconcile with traditional models of cartilage-antigen-driven inflammatory disease in patients with RA. (biomedcentral.com)
Exposure to agricultur al bioaerosols can lead to chronic inflammatory lung diseases. (cdc.gov)

For patients who have had a prior biopsy, the saved sample can be stained for mast cells. (medscape.com)

Since SLAMF receptors play a role in NK cell biology, we reasoned that these receptors may impact NK cell-mediated CLL immunity. (nature.com)
Together, our data indicate that SLAMF receptors are important modulators of the BCR signaling axis and may improve immune control in CLL by interference with NK cells. (nature.com)
Signaling Lymphocytic Activation Molecule Family (SLAMF) receptors are a group of nine type I transmembrane receptors that are mainly expressed on a variety of immune cells. (nature.com)
In B cells, this class of receptors has been shown to be expressed in distinct patterns associated with development and activation [ 11 ]. (nature.com)
A previous study demonstrated that SLAMF1, SLAMF2, and SLAMF7 receptors are rather downregulated on CLL cells as compared to their normal B cell counterpart [ 12 ], suggesting that high expression of these molecules may have detrimental (e.g., antiproliferative) effects in the CLL context. (nature.com)
The vast diversity of possible T-cell receptors (TCR) is generated by the random recombination of genes in the third complimentary determining regions (CDR3) within a TCR's α and β chains. (biorxiv.org)
The generation of receptors specific for antigens is a unique and complex process that generates 10 12 specific receptors for each cell type of the adaptive immune system, including T and B cells. (medscape.com)
Various cell types can process and present these antigens to T cells, or antigens may be soluble and bound to B-cell receptors. (medscape.com)

Great Bear Healthcare is the first acquisition since Clinisupplies became a KKR portfolio company in January 2023 and is allied to the ambition of building an international chronic care medical devices platform. (yahoo.com)

Conducted by a multi-institutional team of researchers in Japan who had developed the new therapy, the study was designed to confirm that their treatment-which involves transplanting the patient's own mesenchymal stem cells (MSCs) into the affected knee-did not cause tumors. (medicalxpress.com)
Mitsuru Mizuno et al, Transplantation of human autologous synovial mesenchymal stem cells with trisomy 7 into the knee joint and 5 years of follow‐up, STEM CELLS Translational Medicine (2021). (medicalxpress.com)

Researchers identified that an abundance of fungi in the gut, particularly strains of Candida albicans yeast, could trigger an increase in immune cells, which could worsen lung damage. (medicaldaily.com)
The number of CD8 + ve cells in both lung parenchyma and pulmonary arteries was significantly correlated with the degree of airflow limitation in smokers. (atsjournals.org)

However, certain factors such as low junctional diversity, thymic selection, and T-cell proliferation upon antigen exposure can affect TCR sharing among individuals. (biorxiv.org)
10 8 By contrast, chronic exposure to IL-1 leads to exhaustion of normal HSC. (haematologica.org)
In males, exposure to stress conditions , especially chronic stress, changed not only the gene expression in these cells and their interactions with surrounding nerve cells but also their very structure. (anxiety-stress-management.com)
In females, however, no significant change was observed in these cells, and they were not susceptible to stress exposure. (anxiety-stress-management.com)
Studies reveal that chronic exposure of T cells to TNF uncouples TCR signal transduction pathways by impairing the assembly and stability of the TCR/CD3 complex at the cell surface. (biomedcentral.com)

[9] If enlarged lymph nodes are caused by infiltrating CLL-type cells, a diagnosis of small lymphocytic lymphoma (SLL) is made. (wikipedia.org)

With an emerging technology called single-cell RNA-sequencing, scientists can now interrogate thousands of cells at once to see which cells are altered during chronic pain, and in which ways the cells change. (wraltechwire.com)

1 Unique MSC-specific markers have not yet been identified, and MSCs constitute a heterogeneous cell population, including both multipotent (stem) cells and progenitor cells and might even contain pluripotent cell fractions. (bmj.com)

The main risk still remains the "graft-versus-host reaction", in which donor cells attack the patient's own cells, which are foreign to them. (disabled-world.com)

The origin is a dendritic cell, although previously thought to be a histiocyte, a term still used. (wikipedia.org)
These cells have a plasmacytoid dendritic cell phenotype, a distinct response to TLR ligation and present antigen to T cells far less efficiently on comparison to conventional CD11c(hi) dendritic cells. (cam.ac.uk)
These properties have made lentiviral vectors advantageous for use in dendritic cell (DC) vaccines. (jci.org)

Treatments that target these scarred regions or regulatory molecules expressed by the immune cells might help restore the cells' function. (massgeneral.org)
The management of patients with chronic lymphocytic leukemia and mantle cell lymphoma who are treated with BTK inhibitors comes with intolerance and resistance challenges and therefore there is a continuous unmet need for novel treatments. (lls.org)
One reason why strong pain relievers work well but can have dramatic side effects has to do with a basic biological fact: pain involves a highly diverse set of cells and current treatments lack cell type specificity. (wraltechwire.com)
Chronic Lyme Disease is something that is no longer considered a medical condition, though treatments for it continue to be advertised by sketchy alternative medicine providers. (stackexchange.com)
Although there are many treatments for IBD, a number of patients fail to respond long-term, leaving those afflicted with a host of chronic issues, from abdominal pain and cramping to frequent, bloody stools. (scitechdaily.com)
Certain cancer treatments may affect a person's white blood cell count, leading to leukopenia. (medicalnewstoday.com)

In this review, we discuss the rationale for MSC-based cell therapy in COPD, the main findings from in vitro and in vivo preclinical COPD model studies, clinical trials in patients with COPD and directions for further research. (bmj.com)
A study released in Stem Cells Translational Medicine has confirmed the safety of a novel type of cellular therapy for knee pain caused by osteoarthritis. (medicalxpress.com)
The use of our own stem cells continue to show great success in the field of regenerative therapy," Dr. Theofilos said in a statement. (worldnewsstand.net)
JOA displayed the activity of inhibiting the BCR-ABL and promoted differentiation of not only imatinib -sensitive but also imatinib -resistant cells with BCR-ABL mutation, which could become a potent lead compound to overcome the imatinib -resistant induced by inhibitors of BCR-ABL tyrosine kinase in CML therapy. (jcancer.org)
Reports have shown successful use of sildenafil as a prophylactic treatment but have failed to address adverse outcomes, including vasoocclusive pain crises, of chronic sildenafil therapy in sickle cell patients. (qxmd.com)

To figure out which cells were changing and in what ways, Zylka's lab performed single-cell RNA-sequencing on the spinal cords of mice with neuropathic pain, a type of chronic pain caused by nerve damage. (wraltechwire.com)
Researchers from King's sought to answer this question by examining immune cells in the nervous system of mice, which are known to be important for the generation of persistent pain. (vetscite.org)
The injection of chronically infected mice with a lentiviral vector encoding LCMV MHC class I and II T cell epitopes and a soluble programmed cell death 1 microbody rapidly cleared the virus. (jci.org)
Human neural stem cells restore motor function in mice with chronic spinal cord injury. (uci.edu)
The Anderson-Cummings team transplanted human neural stem cells into mice 30 days after a spinal cord injury caused hind-limb paralysis. (uci.edu)

Chronic multifocal Langerhans cell histiocytosis, previously known as Hand-Schüller-Christian disease, is a type of Langerhans cell histiocytosis (LCH), which can affect multiple organs. (wikipedia.org)
This trial is one of the first randomized, sham-controlled studies to test the efficacy of administering adult-derived stem cells in patients disabled with a chronic stroke," said Sean I. Savitz, M.D., professor and the Frank M. Yatsu Chair in Neurology at McGovern Medical School and director of the UTHealth Institute for Stroke and Cerebrovascular Disease. (news-medical.net)
Chronic knee pain is a major issue for the aging, affecting approximately 25 percent of all adults, according to the Centers for Disease Control and Prevention (CDC). (medicalxpress.com)
Roughly one-fifth of the U.S. population has chronic pain, according to the Centers for Disease Control and Prevention. (wraltechwire.com)
It has recently been shown that the homogeneity of the chromatin landscape between CLL cells contrasts with the important observed genetic heterogeneity of the disease. (whiterose.ac.uk)
To gain further insight into the consequences of disease evolution on the epigenome's plasticity, we monitored changes in chromatin structure occurring in vivo in CLL cells from patients receiving continuous Ibrutinib treatment. (whiterose.ac.uk)
A better question may be 'Is chronic Lyme disease a real thing? (stackexchange.com)
I am pretty sure people have chronic symptoms from Lyme's disease, when untreated. (stackexchange.com)
Chronic Lyme Disease is basically a medically condition once believed to be from persistent presence of Lyme disease in a treated patient, however it is no longer believed to have any medical merit. (stackexchange.com)
Chronic symptoms from untreated Lyme disease are definitely a thing, but 'Chronic Lyme Disease' is not something that actually happens to treated patients. (stackexchange.com)
Disease was distinct from typical aspergillosis, being chronic and spreading in a contiguous manner across anatomical planes. (cdc.gov)
Much effort has focussed on establishing the molecular nature of antigenic reactivity, in the belief that the established chronic phase of the disease is antigen-driven. (biomedcentral.com)
The immune system is comprised of highly specialized q The findings and conclusions in this report are those of the authors and cells, tissues, and organs that give the human body the do not necessarily represent the views of the Agency for Toxic Substances and Disease Registry. (cdc.gov)

Antigen recognition depends on both T-cell specificity and the molecular complex presenting the antigen. (biorxiv.org)

Recombination of the TCRα chain includes only V and J gene segments, resulting in fewer possible rearrangements and making the TCRβ chain a more suitable target for identifying unique T cells, and thus the focus of this paper. (biorxiv.org)
The researchers mapped out gene expression in more than 35,000 individual cells, generating a huge amount of data that provides a picture of stress response that's unprecedented in its scope and in highlighting the differences between how males and females perceive and process stress. (anxiety-stress-management.com)
The website will, for example, allow researchers who are focusing on a specific gene to see how that gene's expression changes in a certain cell type in response to stress, in males as well as females," Brivio explains. (anxiety-stress-management.com)
The comprehensive mapping has already allowed the researchers to identify a long list of differences in gene expression - between males and females, and between chronic and acute stress. (anxiety-stress-management.com)
TP53 gene defects represent the most unfavorable prognostic factor in chronic lymphocytic leukemia (CLL). (muni.cz)
For the gene family, see B-cell CLL/lymphoma . (wikipedia.org)

In summary, we identify myostatin propeptide as a novel positive regulator of primitive CML cells and corresponding normal hematopoietic cells. (haematologica.org)

It is crucial to control the transplanted donor immune cells so that the effect is strong enough to eliminate the leukemia cells but not strong enough to lead to complications in other tissues and organs. (disabled-world.com)

Immune cells that lose function and become exhausted during chronic infections develop long-term "scars" in regulatory elements of the genome and do not fully recover after the virus is cleared. (massgeneral.org)
If correct, this could indicate a short window of opportunity early during chronic infections to protect T cell function," says Lauer. (massgeneral.org)
Researchers have discovered a molecular mechanism that may help to explain how viruses that cause chronic infections, such as HIV or hepatitis c virus, manage to outsmart their hosts' immune systems. (futurity.org)
Fighting off infections depends largely on our bodies' capacity to quickly recognize infected cells and destroy them, a job carried out by a class of immune cells known as CD8 + T cells. (futurity.org)

For a large percentage of patients, highly sensitive tests were conducted regularly to detect any remaining leukemia cells after the transplantation. (disabled-world.com)
However, this is also the mechanism by which the leukemia cells are eliminated. (disabled-world.com)
Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in the western world. (europa.eu)
B cell chronic lymphocytic leukemia (CLL) is the most frequent leukemia in adults. (europa.eu)
With that in mind, this Clinical Advances in BTK Inhibitors for Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma was created to provide a broad range of educational activities on ongoing therapeutic developments in a variety of program formats to appeal to your individual learning preferences. (lls.org)
In previous research, the authors demonstrated that the methanol extract of Artemisia vulgaris (AVM) has the ability to inhibit chronic myeloid leukemia (CML) cell proliferation. (spandidos-publications.com)
According to the Leukemia & Lymphoma Society , a healthy white blood cell count is 5,000-10,000 white cells per microliter (µL) of blood for males and children, and 3,500-11,000 white cells per µL for females. (medicalnewstoday.com)

These three classes of killer cell could all play an important part in the pathogenesis of COPD. (nih.gov)

Cell-to-cell interactions set off a cascade of events that may result in T- or B-cell activation and, ultimately, host defense. (medscape.com)

Methods: T cells from chronic HCV patients and healthy individuals were analysed for expression of CXCR5, PD-1, ICOS, and IL-21 and IFN-c production by flow cytometry. (eur.nl)

CD11c(lo) cells polarise naive T cells to distinct T cells lineages, encouraging the expansion of antigen-specific Foxp3 T cells and polarisation away from Th17 cells. (cam.ac.uk)

Medulloblastoma (MB) is a malignant embryonal brain tumour originating from neural stem cells or granule-cell progenitors of the cerebellum, due to a deregulation of signalling pathways involved in neuronal development such as Wnt or Sonic Hedgehog (SHH) [ 1 ]. (biomedcentral.com)
A UC Irvine study is the first to demonstrate that human neural stem cells can restore mobility in cases of chronic spinal cord injury, suggesting the prospect of treating a much broader population of patients. (uci.edu)
Human neural stem cells are a novel therapeutic approach that holds much promise for spinal cord injury," said Anderson, associate professor of physical medicine & rehabilitation and anatomy & neurobiology at UCI. (uci.edu)
This latest study provides additional evidence that human neural stem cells may be a viable treatment approach for them. (uci.edu)
The research is the latest in a series of collaborative studies conducted since 2002 with StemCells Inc. that have focused on the use of StemCells' human neural stem cells in spinal cord injury and resulted in multiple co-authored publications. (uci.edu)

Sickle cell di6

Inflammation10

Reinfused into a pat1

Acute and chronic4

Infection31

Neutrophils5

Responses14

Peripheral6

Immunology1

Graft-versus-2

Cytokine8

Apoptosis4

Treat chronic3

Macrophages5

Receptor13

Obstructive pulmonary3

Granulomatous Disease3

Cytokines4

Lymphocytes6

Viral3

Clonal4

Stem cell25

Indicating its pote1

Innate6

Treatment of chronic2

Subtype5

Regenerative Medicine1

Bone12

Allogeneic2

Inflammatory9

Mast cells1

Receptors8

20231

Mesenchymal stem2

Lung2

Exposure5

Lymph nodes1

Altered during chron1

Progenitor cells1

Patient's1

Dendritic cell3

Treatments6

Therapy5

Mice5

Disease13

Specificity1

Gene6

Hematopoietic cells1

Tissues1

Infections4

Leukemia7

Pathogenesis1

Interactions1

Flow cytometry1

Antigen-specific1

Neural stem5