Cell cell satellite cells. Medical search. Frequent questions

Analysis of satellite cell dynamics on myofibers confirms that HIF1α/2α dKO myoblasts exhibit reduced self-renewal but more pronounced myogenic differentiation under hypoxia conditions. (purdue.edu)
In the resected muscle and in the passively stretched antagonist muscle, there was a dramatic increase in the number of myofibers positive for neonatal MyHC and in the number of BrdU- and MyoD-positive satellite cells. (arvojournals.org)
Both active and passive stretch of the rectus muscles produced by strabismus surgery dramatically upregulated the processes of satellite cell activation, integration of new myonuclei into existing myofibers, and concomitant upregulation of immature myosin heavy chain isoforms. (arvojournals.org)
1 2 Residing outside the sarcolemma but within the basal lamina of individual myofibers is a population of cells that are responsible for muscle repair and regeneration, the satellite cells. (arvojournals.org)
3 When a muscle is injured, this specialized cell population becomes activated, divides, and either repairs damaged fibers or forms new myofibers. (arvojournals.org)
The percentages of MyoD- and Pax7-positive satellite cells per 100 myofibers in cross section were calculated. (umn.edu)
In the underacting medial rectus muscles, the percentages of MyoD- and Pax7-positive satellite cells, based on the number of myofibers, were approximately twofold higher than the percentages in the control muscles. (umn.edu)
Postnatal growth and repair of skeletal muscle relies upon a population of quiescent muscle precursor cells, called satellite cells that can be activated to proliferate and differentiate into new myofibers, as well as self-renew to replenish the satellite cell population. (biomedcentral.com)
Rodents with conditional mutilation of Ezh2 in Pax7-produced muscle mass precursor cells possess decreased muscle mass mass with smaller sized myofibers was selectively ablated in Pax7-produced cells by traversing knock-in rodents articulating Cre recombinase from the Pax7 locus (alleles (Su et al. (cancer-ecosystem.com)
Histopathological changes including excess collagen deposition around myofibers, cell necrosis, inflammatory cell infiltration, and increased cytokine expression result from eccentric exercise, forced lengthening, exertion-induced injury, and repetitive strain-induced injury of muscles. (cdc.gov)

However, HIF1α/2α dKO in postnatal satellite cells impairs injury-induced muscle repair, accompanied by a reduced number of myoblasts during regeneration. (purdue.edu)
6 These manipulations result in satellite cell activation and proliferation, which in turn are responsible for muscle repair and regeneration. (arvojournals.org)
The upregulation in the number of MyoD-positive satellite cells in underacting muscles suggests that there is potential for successful upregulation of size in these muscles, as the cellular machinery for muscle repair and regeneration, the satellite cells, is retained and active in patients with medial rectus underaction. (umn.edu)
Satellite cells (SCs), which are adult skeletal muscle stem cells, are the main players of the skeletal muscle regeneration process. (elsevierpure.com)
Using genetic tools to conditionally abrogate C/EBPβ expression in Pax7 + cells, we examined the role of C/EBPβ in self-renewal of satellite cells during muscle regeneration. (biomedcentral.com)
After a single muscle injury, C/EBPβ-deficient satellite cells fail to self-renew resulting in a reduction of satellite cells available for future rounds of regeneration. (biomedcentral.com)
These findings demonstrate that C/EBPβ is a novel regulator of satellite cell self-renewal during muscle regeneration acting at least in part through Notch2. (biomedcentral.com)
Satellite cell content, activation and apoptosis were determined via immunohistochemistry, as were muscle fibre regeneration and myonuclear apoptosis. (utmb.edu)
PLF was located in satellite cells and/ or myoblasts, which increased in number with continued task performance, supporting our hypothesis that PLF plays a role in muscle repair or regeneration. (cdc.gov)

Finally, we show that template DNA cosegregates with Numb in label-retaining cells that express the self-renewal marker Pax7. (nih.gov)
Cross sections were obtained and stained immunohistochemically for the presence of activated satellite cells, as identified by MyoD immunoreactivity, and the presence of the total satellite cell population, as identified by Pax7 immunoreactivity. (umn.edu)
In the overacting medial rectus muscles, the percentage of MyoD-positive satellite cells was twofold less than in the control muscles, whereas the percentage of Pax7-positive satellite cells significantly increased compared with that in the control specimens. (umn.edu)
An antibody against Pax7 and immunocytochemical techniques were used to identify satellite cells. (uaeu.ac.ae)
The transcription factor CCAAT/enhancer binding protein beta (C/EBPβ) is expressed in Pax7 + satellite cells of healthy muscle and is downregulated during myoblast differentiation. (biomedcentral.com)
mutilation in Pax7-produced skeletal muscle mass AZD8330 manufacture cells outcomes in problems of postnatal muscle mass development characterized by decreased muscle mass mass with smaller sized muscle mass materials. (cancer-ecosystem.com)
The decreased quantity of Pax7+ cells in = 2) 3 m after CTX, probed with myogenin, Pax7, and GAPDH antibodies. (cancer-ecosystem.com)
Skeletal muscle satellite cells were obtained by tissue block culture method in combination with pre-plating techniques , and the purity of these cells was detected by both immunocytochemistry and fluorescence activated cell sorter (FACS) with Pax7 as marker of SMSC. (bvsalud.org)
After purification by pre-plating techniques , more than 97.6% of the cells expressed Pax7, a unique marker of satellite cells . (bvsalud.org)

The spreading satellite glial cell activation within the TG results in mechanical hypersensitivity of face regions not directly associated with the trigeminal nerve injury. (iasp-pain.org)

Muscle satellite cells are myogenic stem cells whose quiescence, activation, self-renewal and differentiation are influenced by microenvironment oxygen levels. (purdue.edu)
When overexpressed in the murine myoblast cell line C2C12 or in primary myoblasts, C/EBPβ reduced MyoD and other myogenic protein levels during differentiation, in addition to reducing myoblast fusion. (biomedcentral.com)
The in dedicated skeletal myogenic cells (MyoD+ cells), we carefully bred rodents (Supplemental Fig. H5A). (cancer-ecosystem.com)
Body and muscle mass mass had been significantly decreased in mutilation in skeletal myogenic cells. (cancer-ecosystem.com)
Myogenesis of these cells was induced in differentiation medium and the mRNA expressions of myogenic differentiation gene (MyoD) and Myogenin were determined by Real-time polymerase chain reaction ( PCR ). (bvsalud.org)

However, the in vivo roles of HIFs in quiescent satellite cells and activated satellite cells (myoblasts) are poorly understood. (purdue.edu)
10 Even more compelling is a recent study that subjected individual quiescent satellite cells isolated from adult limb muscle to stretching in vitro, and showed that direct stretching of the satellite cells themselves results in activation and bromodeoxyuridine (BrdU) incorporation. (arvojournals.org)

Nandrolone injected birds had on average higher satellite cell frequencies (#SC nuclei/all nuclei within basal lamina), number of satellite cells per millimeter of fiber, and satellite cell concentrations (closer together). (uaeu.ac.ae)

Together, HIF1α and HIF2α are dispensable for muscle stem cell function under normoxia, but are required for maintaining satellite cell self-renewal under hypoxic environment. (purdue.edu)

Satellite cells assure postnatal skeletal muscle growth and repair. (nih.gov)

Although increases in satellite cell numbers and satellite cells giving rise to new myonuclei are associated with hypertrophy in many experimental models, the relationship between nandrolone and satellite cells is poorly understood. (uaeu.ac.ae)

Furthermore, we demonstrate that the asymmetric cell-fate determinant Numb segregates selectively to one daughter cell during mitosis and before differentiation, suggesting that Numb is associated with self-renewal. (nih.gov)
Mechanistically, HIF1α/2α dKO blocks hypoxia-induced activation of Notch signaling, a key determinant of satellite cell self-renewal. (purdue.edu)
Constitutive activation of Notch signaling can rescue HIF1α/2α dKO induced inhibition of satellite cell self-renewal. (purdue.edu)
Findings The present research exposed that EZH2 affects many elements of South carolina biology, including self-renewal, expansion, and cell identification. (cancer-ecosystem.com)

Periostin, on the other hand, was not present in satellite cells and/ or myoblasts. (cdc.gov)

Study on culture, identification and differentiation of primary rat skeletal muscle satellite cells]. (bvsalud.org)
To establish the isolation, culture and identification methods of primary rat skeletal muscle satellite cells (SMSC) and observe its characterization of differentiation in vitro . (bvsalud.org)
Skeletal muscle satellite cells with high purity and strong differentiation ability can be obtained by means of tissue block culture method . (bvsalud.org)

Hypoxia inducible factors (HIFs) are central mediators of cellular responses to fluctuations of oxygen, an environmental regulator of stem cell activity. (purdue.edu)

Although overload-induced muscle fiber hypertrophy is normally associated with satellite cell-mediated myonuclear accretion, hypertrophic adaptation proceeds in the absence of satellite cells in fully grown adult mice, but not in young growing mice. (uky.edu)

Irradiation treatment, which eliminates satellite cells from these muscles, prevents the compensatory hypertrophy in these types of experiments. (arvojournals.org)
Emerging evidence also indicates that satellite cells play an important role in remodeling the extracellular matrix during hypertrophy. (uky.edu)
Our results suggest that satellite cells may be key cellular vectors for nandrolone induced muscle fiber hypertrophy. (uaeu.ac.ae)

Previous studies have derived MRF expression from whole muscle homogenates, but little work has examined whether the mRNA expression of these transcripts reflects the pattern of expression in the actual population of satellite cells (SC). (mcmaster.ca)

As predicted from results in the literature, MyoD-positive satellite cells, indicative of activation, were present in both the control and resected muscles. (umn.edu)

Satellite television cells (SCs) sustain muscle development and empower adult skeletal muscle with strenuous regenerative capabilities. (cancer-ecosystem.com)

Recent loss-of-function studies show that satellite cell depletion does not promote sarcopenia or unloading-induced atrophy, and does not prevent regrowth. (uky.edu)

Each side of the cell body extends outward, forming perineuronal processes. (wikipedia.org)

Simone Spuler, Helena Escobar and Andreas Marg demonstrate that satellite cells can be successfully expanded from human adult muscle biopsies in culture and transplantation of satellite cell-containing human muscle fiber fragments into irradiated mice restores damaged muscle tissue. (mdc-berlin.de)
From the biopsies, muscle stem cells (satellite cells) are isolated and later used for preclinical measurements. (lu.se)

Using pulse-chase labelling with BrdU to mark the putative stem cell niche, we identify a subpopulation of label-retaining satellite cells during growth and after injury. (nih.gov)

combined cell family tree genetics will not really happen in epidermal, neuronal, or pancreatic cells of conditional null rodents (Chen et al. (cancer-ecosystem.com)

The cosegregation of 'immortal' template DNA strands and their link with the asymmetry apparatus has important implications for stem cell biology and cancer. (nih.gov)
EMBO Meeting to attend the 2018 4DN-ASCB Satellite Meeting: Bridging the 4D Genome with Cell Biology from 8 am to 7 pm, on Friday, December 7, at the Marriott Marquis San Diego Hotel and Marina. (ascb.org)
This conference, jointly organized by the 4D Nucleome (4DN) network and the American Society of Cell Biology (ASCB), will feature recent technological and conceptual advances in research of the higher-order chromatin organization in eukaryotic cells. (ascb.org)
The 2018 4DN-ASCB Satellite Meeting aims to highlight rapid progress in the study of genome organization and facilitate the dissemination of new technologies and concepts to the broader cell biology community. (ascb.org)
ASCB®," "The American Society for Cell Biology®," "ASCB AN INTERNATIONAL FORUM FOR CELL BIOLOGY®," "Molecular Biology of the Cell®," and "DORA®" are registered trademarks of The American Society for Cell Biology. (ascb.org)
The Cell: An Image LibraryTM" is a common law trademark of The American Society for Cell Biology. (ascb.org)

The cilium, however, only has the nine pairs of peripheral microtubules while it lacks the axial pair of microtubules, making its structure very similar to the cilia of neurons, Schwann cells, and astrocytes of the CNS. (wikipedia.org)
Satellite glial cells in sensory ganglia are laminar cells that wrap around sensory neurons. (wikipedia.org)
Some sensory neurons have small projections called microvilli that extend outward from their cell surfaces. (wikipedia.org)
In the sympathetic ganglia, satellite glial cells are one of three main types of cells, the other two being the sympathetic ganglion neurons and small intensely fluorescent (SIF) cells. (wikipedia.org)
The present findings suggest that following IANX, satellite glial cells are activated via nitric oxide (NO) signaling from TG neurons. (iasp-pain.org)

marker genes Computational marker genes for this cell type are unavailable at this time. (cziscience.com)

Fluorocitrate administration into the TG significantly reduced the number of GFAP-IR cells and prevented the MHWT reduction in IANX rats. (iasp-pain.org)
Satellite cells undergo concurrent apoptosis and activation acutely following a burn, with a net reduction in satellite cell content compared to healthy controls. (utmb.edu)

Despite their flattened shape, satellite glial cells contain all common organelles necessary to make cellular products and to maintain the homeostatic environment of the cell. (wikipedia.org)
Satellite cell phone service is coming to the masses and should be a viable alternative to the congested and spotty cellular networks. (deadzones.com)

The relative number of neuronal nitric oxide synthase (nNOS)-immunoreactive (IR) cells was significantly higher in IANX rats compared to sham-operated and N-propyl-L-arginine (NPLA)-treated IANX rats. (iasp-pain.org)
Following L-arginine injection into the TG, the MHWT was significantly reduced within 15 min, and the mean number of TG cells encircled by glial fibrillary acidic protein (GFAP)-IR cells was substantially higher. (iasp-pain.org)
The relative number of nNOS-IR cells encircled by GFAP-IR cells was significantly increased in IANX rats. (iasp-pain.org)
All satellite cell indices that were quantified increased significantly in chicken pectoralis with administration of nandrolone. (uaeu.ac.ae)

Involvement of Satellite Cell Activation via Nitric Oxide Signaling in Ectopic Orofacial Hypersensitivity. (iasp-pain.org)
The goal of this study was to determine whether the medial rectus muscles of patients with a history of medial rectus underaction or overaction show alterations in the process of satellite cell activation when compared with normal age-matched control muscles. (umn.edu)
The activation and apoptosis of satellite cells probably impacts the recovery of lean tissue following a severe burn, contributing to prolonged frailty in burn survivors. (utmb.edu)

Instead, they release diffusable cytokines, which mediate the inflammatory reaction and resultant apoptosis of epithelial cells. (medscape.com)

We found a significant decline in muscle satellite cells, which decreases the muscle's capacity to regenerate and repair during aging. (nih.gov)
Skeletal muscle satellite cells (SC) play an important role in muscle repair following injury. (mcmaster.ca)
7 8 9 In fact, passive stretching alone can activate limb muscle satellite cells. (arvojournals.org)
Nitric oxide reverses prednisolone-induced inactivation of muscle satellite cells. (medscape.com)

Additionally, this restrains CubeSats from using higher voltage busses due to the mismatch in solar cell scaling. (usu.edu)

Both satellite glial cells (SGCs) and Schwann cells (the cells that ensheathe some nerve fibers in the PNS) are derived from the neural crest of the embryo during development. (wikipedia.org)

Understanding the effects of strabismus surgery on muscle cell biological reactions and myofiber remodeling may suggest new approaches for improving surgical outcomes. (arvojournals.org)

We speculate that, in dedicated or differentiated cells, the chromatin framework at chosen genomic areas may become insensitive to epigenetic adjustments triggered by mutilation. (cancer-ecosystem.com)
A even more unsuspecting and plastic material chromatin environment, such as that of Sera cells or non-committed Pax7+/Myf5? (cancer-ecosystem.com)

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In some SGCs of the sensory ganglia researchers have seen a single cilium that extends outward from the cell surface near the nucleus and into the extracellular space of a deep indentation in the plasma membrane. (wikipedia.org)

2009). We produced rodents in AZD8330 manufacture which was conditionally ablated in SCs (muscle mass knockout, mouse, where cells that communicate or possess ever indicated Myf5-Cre are YFP+, while cells that possess by no means indicated Myf5-Cre are YFP? (cancer-ecosystem.com)
Unlike additional research in which removal was conditionally acquired in dedicated progenitors or differentiated cells (Chen et al. (cancer-ecosystem.com)

Here we test the hypothesis that nandrolone administration is associated with an increase in satellite cell numbers in muscle. (uaeu.ac.ae)
Other evidence supports the hypothesis that the disease is the result of cell-mediated immune reactions. (medscape.com)

The presence of an increased number of activated satellite cells in the resected underacting medial rectus muscles and the decreased numbers of activated satellite cells in the overacting muscles was unexpected. (umn.edu)
The decreased number of activated satellite cells in overacting MR muscle suggests that factors as yet unknown in these overacting muscles are able to affect the number of satellite cells and/or their responsiveness compared with normal age-matched control muscles. (umn.edu)

It is widely accepted as an important energy source for many cell types and more recently has been proposed to actively participate in cell-cell communication. (elsevierpure.com)

In a SGC, the cell body is denoted by the region containing the single, relatively large nucleus. (wikipedia.org)

Anatomy23

Organisms15

Diseases7

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes20

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science5

Health Care2

Myofibers10

Regeneration9

Pax79

Glial cell1

Myogenic5

Quiescent2

Basal lamina1

Required for maintaining satellite cell1

Postnatal1

Myonuclei1

Self-renewal4

Myoblasts1

Differentiation3

Regulator1

Myonuclear1

Hypertrophy3

MRNA1

MyoD1

Regenerative1

Sarcopenia1

Perineuronal1

Biopsies2

Stem cell1

Genetics1

Biology6

Neurons5

Marker1

Reduction2

Cellular2

Significantly4

Activation3

Apoptosis1

Muscle satellite cells4

Additionally1

Nerve1

Strabismus1

Chromatin2

Battery4

Extracellular1

Conditionally2

Hypothesis2

Muscles2

Types1

Nucleus1