Cell cell cell proliferation clone cells. Medical search. Frequent questions

In normal human subjects a small proportion of peripheral blood T-cells simultaneously express both CD4 and CD8 differentiation antigens. (uninsubria.it)
TIGIT also promotes the differentiation of tolerogenic phenotype in dendritic cells with an increased secretion of IL-10 and a diminished production of IL-12. (biolegend.com)
The purpose of this study was to determine the acute and long-term effects of mitomycin C (MMC) on quiescent rabbit corneal keratocytes regarding cell proliferation, myofibroblast differentiation and DNA repair. (molvis.org)
MMC significantly blocked TGFβ-induced cell proliferation and myofibroblast differentiation in cultured quiescent keratocytes and altered the transcriptional regulation of macrophage chemotactic protein-1 (MCP-1) and alpha smooth muscle actin (αSMA). (molvis.org)
The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)
Myelophthisis is a form of bone marrow failure that results from the destruction of bone marrow precursor cells and their stroma, which nurture these cells to maturation and differentiation. (medscape.com)
Preferential differentiation of T cell receptor specificities based on the MHC glycoproteins encountered during development. (silverchair.com)
Direct responsiveness of cloned cells to recombinant interleukin 2 by differentiation in the absence of enhanced proliferation. (silverchair.com)
Several cells are known to initiate the process of plasma cell differentiation and are known collectively as antigen presenting cells (APCs) (Waller & Renwick, 1994). (referat.ru)
the regulation of the proliferation, differentiation and activity of leukocytes (Dale et. (referat.ru)
These malignancies are further characterized by the maturity and differentiation of the individual cell types and are divided into acute leukemias such as acute myeloid leukemia and acute lymphoblastic leukemia and chronic leukemias such as chronic myeloid leukemia and chronic lymphocytic leukemia. (medscape.com)
Different characteristics of the nuclei and cytoplasm of the cell allow differentiation by instrumentation and microscopy. (medscape.com)

To address whether the expression of the CD8 receptor on the cell membrane was associated to differences in the physiology of the T-cells, we isolated, from the same clone, CD4 single positive (SP) cells from those co-expressing CD4/CD8 receptors (DP cells) and stimulated them in vitro with antigen presenting cells (APC) carrying TSHR. (uninsubria.it)
Initially, all antibodies are of the first form, attached to the surface of a B cell - these are then referred to as B-cell receptors (BCR). (wikipedia.org)
The terms antibody and immunoglobulin are often used interchangeably, [1] though the term 'antibody' is sometimes reserved for the secreted, soluble form, i.e. excluding B-cell receptors. (wikipedia.org)
These experiments suggest that effects of androgens on developing B cells are mediated through androgen receptors in bone marrow stromal cells. (jci.org)
The diverse repertoire of T-cell receptors (TCR) plays a key role in the adaptive immune response to infections. (elifesciences.org)
In a new study, researchers identified five different olfactory receptors on the surface of the skin and cloned one of those receptors, Discovery News reports . (smithsonianmag.com)
They exposed the cloned receptors to ten different synthetic odors derived from sandalwood-which was used by ancient East Asians as both a perfume and a healing agent-as well as to actual sandalwood odors. (smithsonianmag.com)
T cell receptor mediated activation of CD8 T cells induces the expression of IL-10 receptors on these cells. (aacrjournals.org)
Interleukin 2 receptors on human B cells. (silverchair.com)

In this study we characterized a subset of CD4+ clones, from a healthy donor, that is specific for the thyrotropin receptor (TSHR) and that showed cells co-expressing the CD8 receptor. (uninsubria.it)
Increased thyroid cell replication predisposes single cells to somatic mutations of the TSH receptor. (medscape.com)
Constitutive activation of the TSH receptor may generate autocrine factors that promote further growth, resulting in clonal proliferation. (medscape.com)
The TAM receptor and ligand expression was evaluated in LMS cell lines and 358 sarcoma samples by either gene expression or immunohistochemistry. (nature.com)
The stromal cell requirement for androgen-mediated effects was confirmed in vivo by experiments using chimeric animals created by bone marrow transplantation in which androgen receptor expression was restricted to either the stromal or lymphoid cells of the bone marrow. (jci.org)
The specificity of T-cells is determined by the T-cell receptor (TCR), a heterodimer of alpha and beta protein chains. (elifesciences.org)
T cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as VSTM3 or WUCAM, is a 26 kD, type I transmembrane protein and is a member of the PVR (poliovirus receptor) family of immunoglobulin-like domain containing proteins. (biolegend.com)
Glutamic acid decarboxylase (GAD) sequence 206-220 (designated GAD2) represents a late-stage epitope, but GAD2-specific T cell receptor transgenic T cells producing interferon γ (IFNγ) protect against passive TID. (rupress.org)
It is clear that estrogens increase mammary gland cell proliferation, predominantly via estrogen receptor (ER)-mediated mechanisms in estrogen-dependent breast tumors ( 3 , 4 ). (spandidos-publications.com)
IL-11 acts on cells expressing gp130 and the IL-11 receptor (IL-11R) α subunit. (cellsignal.com)
This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. (cancerindex.org)
The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. (cancerindex.org)
Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. (sigmaaldrich.com)
This study set out to investigate the clinical significance of serum tumor necrosis factor receptor-associated protein 1 (TRAP1) in diagnosing small cell lung cancer (SCLC) with different clinical stages, and to compare the diagnostic efficiency with neuron-specific enolase (NSE), carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9). (bvsalud.org)

Early clinical data suggest imetelstat may have disease-modifying activity through the suppression of malignant progenitor cell clone proliferation, which allows potential recovery of normal hematopoiesis. (globenewswire.com)

Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (merckmanuals.com)
Non-Hodgkin Lymphomas Non-Hodgkin lymphomas are a heterogeneous group of disorders involving malignant monoclonal proliferation of lymphoid cells in lymphoreticular sites, including lymph nodes, bone marrow, the. (merckmanuals.com)
In plasma cell disorders, disproportionate proliferation of one clone in the bone marrow results in a corresponding increase in the serum level of its product, the monoclonal immunoglobulin protein (M-protein). (msdmanuals.com)

SCARA5 promoted cell proliferation and migration but inhibited apoptosis in ESCC. (hindawi.com)
Cell apoptosis was analyzed by flow cytometry. (jcancer.org)
PYCR1 interference was able to inhibit cell proliferation and promote cell apoptosis of pancreatic cancer. (jcancer.org)
TRIM13 inhibited cell proliferation and induced cell apoptosis by regulating NF-κB pathway in non-small-cell lung carcinoma cells. (cancerindex.org)
TRIM13-induced NSCLC cell apoptosis was attenuated by a caspase-3 inhibitor Ac-DEVD-CHO, suggesting that TRIM13 induced cell apoptosis partially through a caspase-3-dependent pathway. (cancerindex.org)

TYRO3 or AXL gene knockdown reduced cell proliferation/colony formation. (nature.com)
At 10 weeks, Fe2O3-exposed cells displayed significant enhanced proliferation, invasion, soft agar colony formation and colony forming unit ability suggesting a neoplastic-like transformation. (cdc.gov)
MWCNT-exposed cells exhibited increased colony formation ability while nCeO2 was negative in all assays except proliferation. (cdc.gov)
Trisomy 8+ cells showed a significant positive correlation with apoptotic CD34+ cells and capacity for colony formation. (who.int)

The cell survival rate was measured using the principle of water-soluble tetrazolium salt-1 assay, which is a measurement method for cell survival rate. (researchgate.net)
New antitumor strategies using drugs targeted to intracellular signaling involved in cell proliferation and survival, angiogenesis, and metastasis have become promising in recent years. (researchgate.net)
IL-10 stimulates the antigen mediated cytotoxicity, survival and proliferation of intra-tumoral CD8+ T cells and simultaneously dampens chronic inflammation. (aacrjournals.org)
IL-10 activates with STAT3 an essential survival and proliferation signal in antigen activated CD8 T cells. (aacrjournals.org)
New somatic mutations arise and are selected if they confer a selective fitness advantage (e.g., proliferation, survival, etc.) to a founding clone in the context of a pre-existing genomic landscape (i.e., germline variants). (nature.com)
In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that beta-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)

Senescence-associated β-galactosidase (SA-β-gal) assay was implemented to dye β-galactosidases (used as a cell aging biomarker) to measure HDF cell aging by UVA. (researchgate.net)
The proliferation and growth of PDAC cells were detected by Celigo analysis, MTT, and clone formation assay. (jcancer.org)
MMC also induced phosphorylation of the nuclear histone marker of DNA damage, γH2AX (a member of the H2A histone family), without induction of cell cycle entry or immediate DNA repair measured by Comet assay. (molvis.org)
The effects of zeranol on cell proliferation were measured using the MTS assay, aromatase expression levels were determined by immunocytochemical staining and reverse transcription‑polymerase chain reaction, and aromatase enzyme activity and estrogen production were analyzed using corresponding assay kits. (spandidos-publications.com)
The bioactivity of recombinant mIL-11 was determined in a B9 cell proliferation assay. (cellsignal.com)

After encountering the appropriate antigen, some B cells undergo clonal proliferation into plasma cells. (msdmanuals.com)
anemia, or pancytopenia: Clonal cells can infiltrate bone matrix and/or marrow. (msdmanuals.com)

The 3G8 antibody clone blocks neutrophil phagocytosis and stimulates NK cell proliferation. (biolegend.com)
It is related to an abnormal stem cell clone that stimulates increased myelofibrosis and damage. (medscape.com)

Nano-ferric oxide induced neoplastic-like transformation in a human primary cell model: iron homeostasis disruption? (cdc.gov)
The current study evaluated the use of a human primary small airway epithelial cell (pSAEC) model to serve as a Tier I neoplastic transformation screening model for proposed ENM tiered risk assessment. (cdc.gov)
At each time point, exposed cells were evaluated for several cancer hallmarks to evaluate neoplastic transformation potential. (cdc.gov)
Solitary extramedullary plasmacytoma (SEP) is a neoplastic proliferation of a single clone of plasma cells that occur outside of the bone and bone marrow. (scielo.org.za)
Exposure to hormonal growth promoters or endocrine disruptors elevates the probability of histological alterations in human mammary epithelial cells, which may lead to the growth of pre-neoplastic cells ( 16 ). (spandidos-publications.com)
Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
Neoplastic proliferations of white blood cells also cause leukocytosis. (medscape.com)

Furthermore, POGLUT2 knockdown of breast cancer cells was established, followed by in vitro biological function assays and in vivo tumor growth study. (frontiersin.org)
This clone can suppress anti-CD3 induced T cell proliferation in vitro based on in-house testing. (biolegend.com)
Sub-chronic in vitro exposures with cancer hallmark screening using human primary cell models holds promise as a Tier I screening model for ENM-associated tumorigenesis. (cdc.gov)
A previous report demonstrated that zeranol is comparable to natural 17β-estradiol (E2) and the synthetic estrogen diethylstilbestrol in its ability to transform MCF-10A normal human breast epithelial cells to a pre-cancerous phenotype in vitro ( 17 ). (spandidos-publications.com)

Here we describe the results from a phase Ib clinical trial (NCT02274155) in which 17 patients with locally advanced head and neck squamous cell carcinoma (HNSCC) received a murine anti-human OX40 agonist antibody (MEDI6469) prior to definitive surgical resection. (bepress.com)
Using this binding mechanism, an antibody can tag a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly (for example, by blocking a part of a virus that is essential for its invasion). (wikipedia.org)
CD16 binds aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC). (biolegend.com)
T-cells play a crucial role in the immune response to pathogens by mediating antibody formation and clearance of infected cells, and by defining an overall response strategy. (elifesciences.org)
To maximize performance, it is strongly recommended that the reagent be titrated for each application, and that you centrifuge the antibody dilution before adding to the cells at 14,000xg at 2 - 8°C for 10 minutes. (biolegend.com)
Antibody- and T-cell-based approaches to targeting of B-cell maturation antigen have shown efficacy. (merckmanuals.com)
HUMORAL IMMUNITYHumoral or antibody-mediated immunity is associated with B-lymphocyte cells. (referat.ru)
or toxic light chains secreted by the malignant plasma cells): Some M-proteins show antibody activity against self-antigens. (msdmanuals.com)

The acidic TME induced by tumour glycolysis can directly inhibit the cytotoxicity and proliferation of CD8 + T cells, which could actively promote immune escape and inhibit immunotherapy sensitivity [ 9 ]. (biomedcentral.com)
IL-4 or IL-6, in particular IL-6, facilitated IL-2-induced CTL proliferation, but not their cytotoxicity. (johnshopkins.edu)

We explored whether LPL affects (a) lipoprotein transport across bovine aortic endothelial cells or (b) lipoprotein binding to subendothelial cell matrix (retention). (jci.org)
The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. (medscape.com)

The functions of circFAM13B were verified by proliferation assays, glycolysis assays, BCa cells-CD8 + T cell co-culture assays and tumorigenesis experiment among human immune reconstitution NOG mice. (biomedcentral.com)
Cell proliferation was characterized by CCK-8 and clone formation assays. (bvsalud.org)
Experimentally confirmed target genes were identified for the 73 diagnostic miRNAs, from which proliferation genes were selected from CRISPR-Cas9/RNA interference (RNAi) screening assays. (cdc.gov)

SCARA5 expression is significantly downregulated in various tumor tissues including liver cancer (LC), rectal cancer, and glioblastoma [ 15 , 16 ] and might affect cell proliferation and invasion abilities by the focal adhesion kinase (FAK) signaling pathway and epithelial-mesenchymal transition (EMT) [ 5 , 17 - 20 ]. (hindawi.com)

Overview of Plasma Cell Disorders Plasma cell disorders are a diverse group of disorders of unknown etiology characterized by Disproportionate proliferation of a single clone of B cells Presence of a structurally and electrophoretically. (merckmanuals.com)

POGLUT2 was mainly expressed in stromal cells as verified by StromalScore, ESTIMATEScore, ImmuneScore, and Tumor purity, and POGLUT2 was positively correlated with cancer-associated fibroblasts, macrophages, monocytes, and neutrophils in the tumor microenvironment. (frontiersin.org)
Increased levels of POGLUT2 could result in the dysregulated immune cell infiltration and tumor microenvironment and showed a significant regulatory effect on the progression of breast cancer through Notch-related signaling. (frontiersin.org)
The response to immune checkpoint blockade, depends on a pre-existing, CD8 T cell-rich tumor microenvironment. (aacrjournals.org)

MMC induces DNA damage to quiescent corneal keratocytes, which remains unrepaired, resulting in abnormal cell replication and gene transcription that leads to long-term effects on corneal repair. (molvis.org)
These are the malignant proliferations of abnormal clones of white blood cells within the bone marrow that are broadly categorized into lymphoid and myeloid neoplasms depending on the type of white cell proliferation. (medscape.com)

Together with B and T cells , antibodies comprise the most important part of the adaptive immune system . (wikipedia.org)
After an antigen binds to a BCR, the B cell activates to proliferate and differentiate into either plasma cells , which secrete soluble antibodies with the same paratope, or memory B cells , which survive in the body to enable long-lasting immunity to the antigen. (wikipedia.org)
When fluorochrome conjugated antibodies are bound to BD® CompBeads, they have spectral properties very similar to cells. (bdbiosciences.com)
TotalSeq™-D antibodies are compatible with Mission Bio's Tapestri Single-Cell Sequencing Platform for simultaneous detection of DNA and Protein. (biolegend.com)
a clone of plasma cells capable of the production of antibodies. (referat.ru)

High-dose melphalan followed by autologous peripheral blood stem cell transplantation may also be used. (merckmanuals.com)
The role of uncultured melanoma cells in the proliferation of autologous tumor-specific cytotoxic T lymphocytes (CTLs) was investigated. (johnshopkins.edu)
Uncultured autologous tumor cells by themselves induced modest, but significant, proliferation in 10 of 13 (77%) CTL clones and in only two of nine non-CTL clones. (johnshopkins.edu)
Autologous tumor-induced CTL proliferation declined with increasing age of the culture. (johnshopkins.edu)
In all these five CTL clones, autologous tumor cells suppressed IL-2-induced proliferation. (johnshopkins.edu)
The remaining four CTL clones, however, required both uncultured autologous melanoma cells and IL-2 for the proliferation. (johnshopkins.edu)

The results demonstrated that low dose zeranol (2‑50 nM) was able to significantly promote cell proliferation, aromatase mRNA expression, aromatase activity and estrogen production in primary cultured human breast preadipocytes, thus suggesting that zeranol may act as an aromatase activator. (spandidos-publications.com)
It was demonstrated that expression of interleukin‑8 (IL‑8) mRNA was significantly upregulated in Gem‑R PaCa cells by cDNA microarray and RT‑qPCR analyses. (cancerindex.org)
Proximal tubule cells exposed to PMA for 2 h demonstrated a two- to threefold increase in Na/H antiporter mRNA (mRNANa/H) abundance 4 h later. (jci.org)
Further mRNA sequencing was conducted, and the association of circFAM13B with glycolysis process and CD8 + T cell activation was confirmed. (biomedcentral.com)
We found that TRIM13 mRNA and protein expression was reduced in NSCLC tissues and cell lines in comparison to paired non-cancerous tissues and a human normal bronchial epithelial cell line, respectively. (cancerindex.org)

One of the potential factors that contributes to breast carcinogenesis is the increased exposure of epithelial cells to estrogens produced locally by the tissue microenvironment ( 2 ). (spandidos-publications.com)
Preadipocytes and adipocytes are major cell types present in the breast adipose tissue microenvironment ( 10 ). (spandidos-publications.com)
The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)
The function of CD8 + T cells was promoted by circFAM13B, and it could attenuate the glycolysis of BCa cells and reverse the acidic tumour microenvironment (TME). (biomedcentral.com)
During glycolysis, the tumour cells consume glucose, produce lactic acid and release it into the tumour microenvironment (TME), thus reducing the pH value of the TME [ 8 ]. (biomedcentral.com)

We hypothesized that, in CBD, failure of IL-10 to modulate the beryllium-specific, cell-mediated immune response would result in persistent, maximal cytokine production and T lymphocyte proliferation, thus contributing to the development of granulomatous lung disease. (cdc.gov)
bronchoalveolar lavage cells from control and CBD subjects to evaluate the beryllium salt-specific production of endogenous IL-10 and the effects of exogenous human rIL-10 (rhIL-10) on HLA expression, on the production of IL-2, IFN- , and TNF- , and on T lymphocyte proliferation. (cdc.gov)
Our data demonstrate that beryllium-stimulated bronchoalveolar lavage cells produce IL-10, and the neutralization of endogenous IL-10 does not increase significantly cytokine production, HLA expression, or T lymphocyte pro- liferation. (cdc.gov)
however, we measured no change in T lymphocyte proliferation or in the percentage of alveolar macrophages expressing HLA-DP. (cdc.gov)
exogenous rhIL-10 has a limited effect on cytokine production and no effect on T lymphocyte proliferation or HLA expression. (cdc.gov)
CMIR)3 and, in the presence of persistent Ag, in the stricted, beryllium salt-specific T lymphocyte proliferation (1-3). (cdc.gov)

In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was significantly altered in cells overexpressing DEFB1, suggesting this to be one of the pathways by which defensin regulates IAV replication in HBEpCs. (cdc.gov)
High-risk MDS cases had a significantly higher percentage of apoptotic CD34+ cells and anti-apoptotic survivin+ cells than controls, particularly for trisomy 8 cases. (who.int)

Sandalore activated the cloned smeller cells in skin, thereby inducing a calcium-signaling cascade that dramatically increased the proliferation and migration of cells," Discovery News describes. (smithsonianmag.com)

Expression, gene mutation and amplification, methylation, and copy number alteration (CNA) of POGLUT2 were evaluated using The Cancer Genome Atlas (TCGA), Cancer Cell Line Encyclopedia (CCLE), and Genotype-Tissue Expression (GTEx) databases. (frontiersin.org)
These data indicate that the effect of MMC on corneal scarring and haze is related to the generation of DNA ICLs leading to defective cell replication and gene expression. (molvis.org)
In addition, the inherited germline variants from these gene signatures were predominately enriched in T cell function, antigen presentation, and cytokine interactions, likely impairing the adaptive and innate immune response thus favoring a pro-tumorigenic environment. (nature.com)
Neither Ir-GLphi gene need be present in the proliferative T cell to generate an immune response to Poly(Glu55Lys36Phe9)n. (silverchair.com)
Significant downregulation of beta-defensin1 gene (DEFB1) expression was observed when human bronchial epithelial cells (HBEpCs) were exposed to IAV. (cdc.gov)

Secondary myelofibrosis is due to implantation or invasion by malignant cancer cells that have metastasized because of implantation of blood-borne tumor cells from a distant cancer. (medscape.com)

instead, we found that PDGF-DD stimulated bulk tumor cell proliferation by induction of paracrine mitogenic signaling between heterogeneous malignant cell clones, some of which expressed PDGFRβ. (lu.se)

RNA interference was used to inhibit the expression of PYCR1 in PANC- 1 and AsPC-1 cells. (jcancer.org)
Because IFNγ is known to inhibit Th17 cells, effective presentation of GAD2 peptide under noninflammatory conditions may protect against TID at advanced disease stages. (rupress.org)
Immunosuppressive cell types such as regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSC) can also be recruited and induced by acidic TME to further inhibit the anti-tumour immune response [ 10 ]. (biomedcentral.com)

The resulting diverse naïve repertoire contains T-cell clones that recognize epitopes of yet unseen pathogens, and can participate in the immune response to infection or vaccination. (elifesciences.org)
CMI) , cellular i. immune responses that are initiated by an antigen-presenting cell interacting with and mediated by T lymphocytes ( e.g., graft rejection, delayed-type hypersensitivity). (theodora.com)
Many tumor microenvironments, including lymphoma and carcinoma, are enriched in immune suppressive cells that contribute to immune exhaustion by means expression of inhibitory ligands, suppressive cytokines, and tumor-promoting factors. (researchgate.net)
Antitumor therapies targeted to reduce the induction, recruitment, or suppressive activities of the immune cells have been investigated. (researchgate.net)
Background: The success of and the durability of immune therapy of cancer is thought to depend on the activation and expansion of tumor reactive and infiltrating CD8+ T cells. (aacrjournals.org)
Interleukin-11 (IL-11) was initially cloned as a mediator of plasmacytoma cell proliferation and was later found to exhibit a wide variety of biological effects in neural cells as well as in the hematopoietic and immune systems (1). (cellsignal.com)
1995). ADAPTIVE IMMUNITYThe adaptive immune system is split into two mechanisms: humoral immunity and cell-mediated immunity. (referat.ru)

Self-recognition specificity expressed by T cells from nude mice. (silverchair.com)

Tripartite Motif Containing 13 (TRIM13), a member of TRIM proteins, is deleted in multiple tumor types, especially in B-cell chronic lymphocytic leukemia and multiple myeloma. (cancerindex.org)
Chemotherapy is based on the principle that, as in myeloma, proliferation of a plasma cell clone causes L chain-type amyloidosis. (medscape.com)

Immature B cells from normal mouse bone marrow were not responsive to the suppressive effect of androgens unless they were cocultured with marrow stromal cells or with supernatants from androgen-treated stromal cells, suggesting that the androgen effects are exerted through marrow stromal elements by production of a diffusible mediator. (jci.org)
Further experiments revealed that bone marrow stromal cells produced TGF-β in response to dihydrotestosterone (DHT), and neutralization of TGF-β in the DHT-treated stromal cells reversed the suppressive effects. (jci.org)
Androgens only affected B cell development in chimeric mice with androgen-sensitive stromal cells. (jci.org)
The stromal cell products responsible for these effects of estrogens have not been identified. (jci.org)
This fibrosis destroys the normal hematopoietic cells and their supportive stromal cells. (medscape.com)

Voltage-gated hydrogen channel 1 is a voltage-gated proton channel that has been shown to allow proton transport into phagosomes and out of many types of cells including spermatozoa, electrically excitable cells and respiratory epithelial cells. (wikipedia.org)
The primary barriers for invading respiratory pathogens are the respiratory tract epithelial cells and antimicrobial proteins generated by these cells. (cdc.gov)

Serial dilutions of Mouse IL-11 Recombinant Protein were added to B9 cells. (cellsignal.com)

Early patch-stage cutaneous T-cell lymphoma. (medscape.com)
Related articles include Cutaneous B-Cell Lymphoma and Cutaneous Pseudolymphoma . (medscape.com)
Among the changes to CTCL classification were the addition of primary cutaneous acral CD8 + T-cell lymphoma as a new provisional entity. (medscape.com)
Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
Human T cell leukemia/lymphoma virus I infection and subsequent cloning of normal human B cells. (silverchair.com)
Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)

Analyses of CD8+ TIL show increases in tumor-antigen reactive, proliferating CD103+ CD39+ cells in 25% of patients with evaluable tumor tissue (N = 4/16), all of whom remain disease-free. (bepress.com)
Myoglobin-reactive T cell clones. (uthscsa.edu)
Reactive leukocytosis can be classified on the basis of the white blood cell type affected. (medscape.com)

It is strongly recommended that when using a reagent for the first time, users compare the spillover on cells and BD® CompBeads to ensure that BD® CompBeads are appropriate for your specific cellular application. (bdbiosciences.com)
ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)

Further studies using fluorescent imaging and protein expression analysis suggested that potential disruption to iron homeostasis gave rise to increased intracellular iron and increased ROS production which is well-known to cause oxidative damage and promote cell transformation. (cdc.gov)

It is expressed on the surface of NK cells, activated monocytes, macrophages, and placental trophoblasts in humans. (biolegend.com)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

circXRCC5 knockdown inhibited cell proliferation and NLRP3-mediated inflammasome activation of glioma cells. (bvsalud.org)
The rescue experiments showed that both overexpression of CLC3 or SGK1 dramatically alleviated circXRCC5 knockdown-induced inhibition of cell proliferation and NLRP3-mediated inflammasome activation of glioma cells. (bvsalud.org)

The experiments explored the hypothesis that the combination of imetelstat and ruxolitinib might create a treatment regimen for MF that could be more efficacious than using either drug alone in reducing myelofibrosis hematopoietic stem cells and hematopoietic progenitor cells. (globenewswire.com)
In the experiments, the regimen of sequential treatment of ruxolitinib followed by imetelstat resulted in greater reductions in the MF hematopoietic stem and progenitor cells, compared to when either drug was used alone or simultaneously. (globenewswire.com)
In addition, the sequential treatment regimen did not affect normal hematopoietic stem and progenitor cells. (globenewswire.com)
As stated in the abstract, these findings suggest that an additive inhibitory activity against malignant myelofibrosis hematopoietic stem and progenitor cells can be achieved using a sequential treatment regimen of ruxolitinib followed by imetelstat. (globenewswire.com)
The bone marrow becomes infiltrated by collagen, reticulin, and other forms of fibrosis, which replace the normal, hematopoietic cells. (medscape.com)
Decreased WBC count, leukopenia, is seen when supply is depleted by infection or treatment such as chemotherapy or radiation therapy, or when a hematopoietic stem cell abnormality does not allow normal growth/maturation within the bone marrow, such as myelodysplastic syndrome or leukemia. (medscape.com)

IL-2 alone was sufficient for the potent proliferation of five of nine CTL clones. (johnshopkins.edu)
2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)

Therefore, it is important to explore candidate genes that could have significance to the clinical diagnosis, as well as the treatment of esophageal squamous cell carcinoma (ESCC) at the molecular level [ 4 ]. (hindawi.com)
Genes inside each cell order it to grow, work, reproduce and die. (nutters.com)
to find regulatory genes of the achaete-scute complex (AS-C). The AS-C comprises four proneural genes that confer to cells the ability to become neuroblasts or sensory organ mother cells ( Campuzano and Modolell, 1992 , review). (biologists.com)
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)

Lesions are caused by bone replacement by expanding plasmacytomas or by cytokines that are secreted by malignant plasma cells that activate osteoclasts and suppress osteoblasts, leading to bone loss. (merckmanuals.com)
Macroglobulinemia is a malignant plasma cell disorder in which B cells produce excessive amounts of IgM M-proteins. (merckmanuals.com)

Uncultured allogeneic melanoma cells mostly failed to induce CTL proliferation. (johnshopkins.edu)

The findings of the present study suggest that zeranol promotes breast cancer cell growth by stimulating aromatase activation and increasing estrogen biosynthesis in adipose tissue. (spandidos-publications.com)
Estrogen production in adipose tissue has previously been demonstrated to provide excessive estrogen for the stimulation and progression of postmenopausal breast cancer cells, and elevated enzymatic activity of aromatase has been detected in the adjacent adipose stroma of breast carcinoma ( 8 , 9 ). (spandidos-publications.com)

TotalSeq™-D reagents are designed to profile protein expression at single cell level. (biolegend.com)
Diagnosis typically requires demonstration of M-protein (sometimes present in urine and not serum but rarely absent entirely) and/or light-chain proteinuria, and excessive plasma cells in the bone marrow. (merckmanuals.com)
In 15 to 20% of patients, plasma cells secrete only Bence Jones protein. (merckmanuals.com)
Long-term activation of protein kinase c causes chronic Na/H antiporter stimulation in cultured proximal tubule cells. (jci.org)
To examine the role of protein kinase C as a chronic regulator of proximal tubule Na/H antiporter activity, the effect of phorbol 12-myristate 13-acetate (PMA) on the Na/H antiporter was studied in cultured proximal tubule cells. (jci.org)
Plasma cell disorders may be suspected because of clinical manifestations, most often bone disease, renal failure, and low blood counts, or an incidental finding of elevated serum protein or proteinuria that leads to further evaluation with serum or urine protein electrophoresis. (msdmanuals.com)

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections 6 , immunoprecipitation 3 , stimulation of NK cell proliferation 4 , blocking of phagocytosis 5 , and blocking of immunoglobulin binding to FcγRIII 7,8 . (biolegend.com)

Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells. (bepress.com)
Thrombospondin type 1 domain-containing 7A ( THSD7A ) was reported to play a procancer role in esophageal squamous cell carcinoma (ESCC). (hindawi.com)

The results demonstrated that CD8 co-expression has a profound effect on the physiology of T helper (Th) cells. (uninsubria.it)
High expression of TYRO3 and AXL was detected in LMS cell lines. (nature.com)
Expression of TIGIT is associated with decreased functionality of CD8 T cells in chronic viral infection and tumors. (biolegend.com)
Concerns have been raised regarding the effects of environmental estrogens as potential regulators of aromatase expression in human breast cells. (spandidos-publications.com)
The present study hypothesized that aromatase expression and activity may be elevated by low dose zeranol exposure, providing a source of estrogens that may stimulate cell proliferation. (spandidos-publications.com)
The present study explored the expression and potential role of TRIM13 in non-small-cell lung carcinoma (NSCLC). (cancerindex.org)
The presence of a subclonal population of tumor cells characterized by PDGFRβ expression was further validated in a cohort of human PanNET. (lu.se)
Our results suggest that although trisomy 8 cells are in a pro-apoptotic state, they are checked by the enhanced expression of anti-apoptotic signals which provide them with their proliferative advantage. (who.int)

Generally, in myelophthisic anemia, a form of fibrosis, occurs secondary to injury by nonhematopoietic cells or pathogens. (medscape.com)

With regard to Gaucher disease, infiltration by cells with "onion-peel" cytoplasm, called Gaucher cells, is caused by a lipid storage disorder (ie, glucosylceramide lipidosis). (medscape.com)

Using TCR alpha and beta repertoire sequencing for T-cell subsets, as well as single-cell RNAseq and TCRseq, we track the concentrations and phenotypes of individual T-cell clones in response to primary and secondary yellow fever immunization - the model for acute infection in humans - showing their large diversity. (elifesciences.org)

[ 2 ] to the presence of a few teardrop-shaped red blood cells and early myeloid precursor cells in the peripheral blood smear. (medscape.com)
This blood film at 1000X magnification demonstrates a leukoerythroblastic blood picture with the presence of precursor cells of the myeloid and erythroid lineage. (medscape.com)
Agnogenic myeloid metaplasia is a stem cell abnormality associated with myeloproliferative diseases. (medscape.com)
The white blood cells (leukocytes) are further divided into phagocytes or myeloid (neutrophils, eosinophils, basophils, monocytes) and immunocytes or lymphoid (lymphocytes). (medscape.com)

The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)

Cell proliferation after exposure to Sandalore also increased by more than 30 percent, the New Scientist adds. (smithsonianmag.com)
Memory cellsOnce the antigens have been destroyed the plasma cells disappear leaving a few as memory cells which enable a swift response upon second exposure to the antigen (Trounce, 1997). (referat.ru)

In summary, uncultured melanoma cells by themselves induced modest levels of CTL proliferation in the context of MHC class II antigens, whereas they suppressed IL-2-induced CTL proliferation in more than half of the clones. (johnshopkins.edu)
Here, they begin to differentiate into mature cells, each of which can respond to a limited number of antigens. (msdmanuals.com)

Anatomy40

Organisms15

Diseases14

Chemicals and Drugs95

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes59

Disciplines and Occupations1

Information Science3

Differentiation13

Receptors9

Receptor14

Progenitor cell1

Monoclonal3

Apoptosis5

Colony formation4

Survival6

Assay5

Clonal2

Stimulates2

Neoplastic7

Vitro4

Antibody8

Cytotoxicity2

Endothelial cells3

Assays3

Signaling pathway1

Disproportionate1

Tumor microenvironment3

Abnormal2

Antibodies5

Autologous6

MRNA5

Microenvironment5

Lymphocyte6

Significantly2

Migration1

Gene5

Invasion1

Heterogeneous1

Inhibit3

Immune7

Specificity1

Myeloma2

Stromal5

Epithelial cells2

Recombinant1

Lymphoma7

Reactive3

Cellular2

Intracellular1

Macrophages2

Knockdown2

Hematopoietic6

Potent2

Genes4

Malignant plasma2

Induce1

Estrogen2

Protein6

Immunoglobulin1

Squamous cell carc2

Expression8

Pathogens1

Cytoplasm1

Immunization1

Myeloid4

Stem cell transplant1

Exposure2

Antigens2