• The formation and maintenance of agrin-induced AChR aggregates required Ca++, Co++ and Mn++ inhibited agrin-induced AChR aggregation and increased the rate of aggregate dispersal. (rupress.org)
  • Although the agrin/MuSK signaling pathway remains largely unknown, changes in intracellular calcium levels are required for agrin-induced AChR aggregation (Megeath and Fallon [1998]: J Neurosci 18: 672-678). (nih.gov)
  • Blockade of L-CaChs in muscle cultures inhibited agrin-induced AChR aggregation but not tyrosine phosphorylation of MuSK or AChR beta subunits. (nih.gov)
  • Therapeutic Effects of Conditioned Medium of Neural Differentiated Human Bone Marrow-Derived Stem Cells on Rotenone-Induced Alpha-Synuclein Aggregation and Apoptosis. (logosbio.com.cn)
  • The abilities of the PAR 1 -targeted agents to desensitize or block PAR 1 in the HEK cell assay were compared with their activities in a human platelet aggregation assay. (aspetjournals.org)
  • Aggregation and deposition of amyloid β-protein (Aβ) in brain is an invariable and initial event in the pathological process of Alzheimer's disease. (hindawi.com)
  • The aggregation of the amyloidogenic polypeptide IAPP (Islet Amyloid Polypeptide, amylin) is believed to play a direct role in the death of pancreatic β-islet cells in type II diabetes. (openbiochemistryjournal.com)
  • These results indicate that myricetin is a strong inhibitor of IAPP amyloid aggregation and a potential lead molecule for the development of an amyloid inhibiting therapeutic. (openbiochemistryjournal.com)
  • beta-amyloid is the main component of neuritic (senile) plaques, which consist of degenerated axonal or dendritic processes, astrocytes, and glial cells around an amyloid core. (msdmanuals.com)
  • citation needed] Environmental stresses such as extreme temperatures and pH or oxidative stress can also lead to protein aggregation. (wikipedia.org)
  • Retinal pigment epithelial (RPE) cells are continually exposed to oxidative stress that contributes to protein misfolding, aggregation and functional abnormalities during aging. (tuni.fi)
  • For the purpose of this study we selected a set of proteins that were misregulated following silencing of TDP-43 and analysed their expression in a TDP-43-aggregation model cell line HEK293 Flp-in Flag-TDP-43-12x-Q/N F4L. (nature.com)
  • In conclusion, by identifying a common set of proteins that are differentially expressed in a similar manner in these two different conditions, we show that TDP-43 aggregation has a comparable effect to TDP-43 knockdown. (nature.com)
  • In molecular biology, protein aggregation is a phenomenon in which intrinsically-disordered or mis-folded proteins aggregate (i.e., accumulate and clump together) either intra- or extracellularly. (wikipedia.org)
  • In these cases, if the cell does not assist the protein in re-folding, or degrade the unfolded protein, the unfolded/misfolded protein may aggregate, in which the exposed hydrophobic portions of the protein may interact with the exposed hydrophobic patches of other proteins. (wikipedia.org)
  • citation needed] In addition to mutations in the affected proteins themselves, protein aggregation could also be caused indirectly through mutations in proteins in regulatory pathways such as the refolding pathway (molecular chaperones) or the ubiquitin-proteasome pathway (ubiquitin ligases). (wikipedia.org)
  • Here, we set to clarify this complex matter and question of whether aggregation is an important constraint in protein evolution that can be the discriminant between beneficial and detrimental situations by considering two cases: we studied molecular evolution of proteins in an endogenous vs. exogenous host. (frontiersin.org)
  • Comprehensive analysis of aggregation-inhibition effects of three major molecular chaperones working in Escherichia coli was conducted for~ 800 aggregation-prone cytosolic proteins. (nii.ac.jp)
  • The results revealed that many of the~ 800 aggregation-prone proteins were solubilized by either one of the two chaperones and most of the proteins that were not solubilized by either one of the three were solubilized by the combination of the three chaperone. (nii.ac.jp)
  • The aggregation of misfolded proteins has been directly linked to diseases such as type II diabetes, Alzheimer's disease and Parkinson's disease. (openbiochemistryjournal.com)
  • [2] [3] The cells within the biofilm produce the EPS components, which are typically a polymeric conglomeration of extracellular polysaccharides , proteins , lipids and DNA . (wikipedia.org)
  • 1. S-Nitrosothiols are nitric oxide (NO) donor drugs that have been shown to inhibit platelet aggregation in platelet rich plasma (PRP) in vitro and to inhibit platelet activation in vivo. (uhi.ac.uk)
  • In a different study, in which researchers systematically analyzed mutations identical to those found in patients with Darier disease, mutant SERCA2 protein aggregates were found to cause stress to the endoplasmic reticulum, subsequently inducing cell apoptosis. (medscape.com)
  • CeO2 exposure was cytotoxic and altered cell function as demonstrated by fibroblast apoptosis and aggregation, and ATII cell hypertrophy and hyperplasia with increased surfactant. (cdc.gov)
  • In wireless communication, carrier aggregation is a technique used to increase the data rate per user, whereby multiple frequency blocks (called component carriers) are assigned to the same user. (wikipedia.org)
  • In addition, load balancing: p.42 is possible with carrier aggregation. (wikipedia.org)
  • p. 113 The case where the component carriers are contiguous in the same frequency band is called intra-band contiguous carrier aggregation. (wikipedia.org)
  • If the component carriers are in the same frequency band but are separated by a gap the carrier aggregation is called intra-band non-contiguous. (wikipedia.org)
  • This is called inter-band carrier aggregation applied to heterogeneous networks. (wikipedia.org)
  • However, the complexity from an radio frequency (RF) point of view is increased in the case inter-band carrier aggregation. (wikipedia.org)
  • Carrier aggregation is also called Dual Cell in the context of UMTS/HSPA+. (wikipedia.org)
  • Through carrier aggregation (part of the UMTS extension HSPA+) two downlink carriers may be assigned to one user since Release 8. (wikipedia.org)
  • Release 10 supports four-carrier aggregation and eight-carrier-aggregation is supported since Release 11. (wikipedia.org)
  • 3GPP standardized carrier aggregation for HSPA+ for the uplink for up to two component carriers since Release 9. (wikipedia.org)
  • p.30 A difference between two aggregated 10 MHz component carriers and a single ordinary 20 MHz channel is that in the case of carrier aggregation the control information is transmitted on both component carriers. (wikipedia.org)
  • LTE Advanced with carrier aggregation allows Gigabit LTE. (wikipedia.org)
  • This is made possible through higher-order modulation (256QAM), carrier aggregation and 4x4 MIMO. (wikipedia.org)
  • S. C. G. Tsinos, F. Foukalas, T. Khattab and L. Lai "On Channel Selection for Carrier Aggregation Systems. (wikipedia.org)
  • F. Foukalas and T. Tsiftsis, "Energy Efficient Power Allocation for Carrier Aggregation in Heterogeneous Networks: Partial Feedback and Circuit Power Consumption. (wikipedia.org)
  • The hemorheological parameters, erythrocyte aggregation and deformability are determined in jaundice patients and are compared with that of healthy subjects. (iospress.com)
  • Laboratoire de Mécanique et d'Acoustique (LMA), Marseille, France Ph.D. Ultrasound characterization of erythrocyte aggregation 2012 - 2013 Specialization in Bio-engineering, Arts et Métiers Paristech, Paris - Bordeaux, France 2009 - 2013 Generalist engineer, Mechanical Engineering. (cnrs-mrs.fr)
  • It was suggested that this optical effect was caused by the morphological change of platelets from discs to spherical cells with pseudopodia ( Latimer et al, 1977 ). (nature.com)
  • White cells are similar to platelets in that they can adhere, aggregate and undergo a release reaction. (dundee.ac.uk)
  • Conclusions: Our data showed that cilostazol can downregulate not only cellular interactions between platelets and monocytic THP1 cells but also platelet P-selectin and CD40L expression. (tmu.edu.tw)
  • 4. Experiments involving measurement of cyclic GMP levels, electrochemical detection of NO and electron paramagnetic resonance of haemoglobin in red blood cells, indicated that scavenging of NO generated from S-nitrosothiols by haemoglobin was responsible for the lack of effect of S-nitrosothiols on platelets in whole blood. (uhi.ac.uk)
  • Potential cellular targets include vascular smooth muscle cells, monocyte/macrophage cell lines, platelets, and endothelial cells. (medscape.com)
  • Here, we show that L-type calcium channels (L-CaChs) are required for full agrin-induced aggregation of AChRs and sufficient to induce agrin-independent AChR aggregation. (nih.gov)
  • Tissue oxygenation depends on hemoglobin as much as on red blood cell (RBC) characteristics such as metabolism, communication with the immune system, deformability and aggregation behavior. (frontiersin.org)
  • Four distinct stages can be defined in the evolution of the extinction coefficient ( k ) according to the aggregation behavior of the polymer donor and the non-fullerene acceptor (NFA). (rsc.org)
  • [10] [11] A cell that switches to the biofilm mode of growth undergoes a phenotypic shift in behavior in which large suites of genes are differentially regulated . (wikipedia.org)
  • Hypoxia-specific ultrasensitive detection of tumours and cancer cells in vivo[J].Nat. (lightpublishing.cn)
  • Using an IAPP-EGFP (Enhanced Green Fluorescent Protein) protein construct, we find that high concentrations of myricetin slowed the in vivo aggregation of IAPP-EGFP. (openbiochemistryjournal.com)
  • Pre-GEPCOT cells could not form neurospheres but expressed the stem cell markers Slc1a3-CreER T , GFAP-CreER T2 , Sox2 CreERT2 , and Gli1 CreERT2 and were long-lived in vivo. (elifesciences.org)
  • Our aim is to develop an ultrasound diagnostic tool allowing to measure quantitative parameters that reflect the red blood cell aggregation state in situ and in vivo . (cnrs-mrs.fr)
  • Shiga toxin-producing Escherichia coli (STEC) is a of STEC strains to invade epithelial cells in vitro, although pathogen that causes gastroenteritis and bloody diarrhea in small numbers ( 2,3 ), but no reports of invasion in vivo but can lead to severe disease, such as hemolytic uremic have been published. (cdc.gov)
  • abstract = "The mucin-type sialoglycoprotein, podoplanin (aggrus), is a platelet-aggregating factor on cancer cells. (elsevierpure.com)
  • In this review, we exhibit the design principle and imaging mechanism of AIE probes for mitochondria target, and their distinguishing imaging between cancer cells and normal cells, circulating tumor cells and leukocyte, and dual identification imaging of cancer cells and related bacteria. (lightpublishing.cn)
  • We observed robust tumor growth in mice transplanted with LMS cell lines expressing TJP1 while no tumor mass was found in mice transplanted with SK-LMS-1 Sh-TJP1 cells with silenced TJP1 expression. (molcells.org)
  • Further analysis revealed two clusters related to cell proliferation and the tumor microenvironment. (molcells.org)
  • Taken together, these results imply that TJP1 contributes to the development of sarcoma by proliferation through modulating cell-cell aggregation and communication through cytokines in the tumor microenvironment and might be a beneficial therapeutic target. (molcells.org)
  • We demonstrate that Hsp90 inhibition by geldanamycin can effectively suppress proteasome inhibitor, MG-132-induced protein aggregation in a way that is independent of HDAC inhibition or the tubulin acetylation levels in ARPE-19 cells. (tuni.fi)
  • The aim of this study was to compare the platelet effects of a novel S-nitrosated glyco-amino acid, RIG200, with an established S-nitrosothiol, S-nitrosoglutathione (GSNO) in PRP, and to investigate the effects of cell-free haemoglobin and red blood cells on S-nitrosothiol-mediated inhibition of platelet aggregation. (uhi.ac.uk)
  • In vitro studies demonstrate that exogenous recombinant Gal3 is internalised by neuronal cell lines and primary neurons where it interacts with endogenous αSyn fibrils. (lu.se)
  • In addition, aggregation experiments show that Gal3 affects spatial propagation and the stability of pre-formed αSyn fibrils resulting in short, amorphous toxic strains. (lu.se)
  • To address these issues, we expressed Reelin ectopically in the developing mouse cortex, and the results showed that Reelin caused the leading processes of migrating neurons to assemble in the Reelin-rich region, which in turn induced their cell bodies to form cellular aggregates around Reelin. (jneurosci.org)
  • Interestingly, the ectopic Reelin-rich region became cell-body-sparse and dendrite-rich, resembling the MZ, and the late-born neurons migrated past their predecessors toward the central Reelin-rich region within the aggregates, resulting in a birthdate-dependent "inside-out" alignment even ectopically. (jneurosci.org)
  • The results showed that ectopic Reelin caused the leading processes of migrating neurons to assemble in the Reelin-rich region, which in turn induced their cell bodies to form aggregates, and the late-born neurons migrated past their predecessors, resulting in a birthdate-dependent "inside-out" alignment within the aggregates. (jneurosci.org)
  • Cells have mechanisms that can refold or degrade protein aggregates. (wikipedia.org)
  • However, as cells age, these control mechanisms are weakened and the cell is less able to resolve the aggregates. (wikipedia.org)
  • Recent studies suggest that brain cell type specific intracellular environments may play important roles in the generation of structurally different protein aggregates that define neurodegenerative diseases. (biomedcentral.com)
  • Using human induced pluripotent stem cells (hiPSC) and biochemical and vibrational spectroscopy techniques, we studied whether Parkinson's disease (PD) patient genomes could modulate alpha-synuclein (aSYN) protein aggregates formation. (biomedcentral.com)
  • This function aggregates the data based on the aggregation function set for members of an Account Dimension. (mssqltips.com)
  • The protein aggregates formed at the cell periphery are delivered along the microtubulus network by dynein-dependent retrograde trafficking to a juxtanuclear location. (tuni.fi)
  • To identify the TJP1-dependent factors important in the development of LMS, genes with altered expression were selected in SK-LMS-1 cells such as cyclinD1, CSF1 and so on. (molcells.org)
  • This work demonstrates the usefulness of the cDNA-AFLP approach to reveal genes that are differentially expressed during aggregation in Azospirillum brasilense and provides insights into the aggregation process of this bacterium. (huji.ac.il)
  • Myricetin was also found to rescue living mammalian cells from the toxic effects of IAPP. (openbiochemistryjournal.com)
  • COX-1 is expressed constitutively and is isolated throughout most cell lines in almost all mammalian tissues. (medscape.com)
  • We found that aggregation differentiates the effects of mutations in the two different cellular contexts. (frontiersin.org)
  • Specifically, aggregation was found to be associated with increased cell fitness in the case of TDP-43 mutations, as it protects the host from aberrant interactions. (frontiersin.org)
  • By contrast, in the case of TEM-1 beta-lactamase mutations, aggregation is linked to a decreased cell fitness due to inactivation of protein function. (frontiersin.org)
  • Any situation, such as mutations or anomalous expression, could result in disruption of these beneficial interactions with consequent aggregation and depletion of normal function. (frontiersin.org)
  • [ 22 ] Investigators transfected a fibroblast cell line with 51 different mutations seen in keratosis follicularis (Darier disease) pedigrees. (medscape.com)
  • Protein aggregation is one of the major cellular hallmarks of neurodegenerative diseases (ND). (biomedcentral.com)
  • The analysed data is represented by aggregation parameters-aggregate size index, aggregate sedimentation time index, total number of fluctuations, time required for completion of process, effective number of cells and effective cellular sedimentation duration. (iospress.com)
  • Microbes form a biofilm in response to a number of different factors, [9] which may include cellular recognition of specific or non-specific attachment sites on a surface, nutritional cues, or in some cases, by exposure of planktonic cells to sub-inhibitory concentrations of antibiotics . (wikipedia.org)
  • First, we established a highly reactive anti-podoplanin antibody, NZ-1, which inhibits podoplanin-induced platelet aggregation completely. (elsevierpure.com)
  • Agrin-induced receptor aggregation also was inhibited by phorbol 12-myristate 13-acetate, an activator of protein kinase C, and by inhibitors of energy metabolism. (rupress.org)
  • Specific inhibitors of RANTES-induced activation, such as soluble glycosaminoglycans, MIP-1alpha and MIP-1beta, acted by preventing the binding of RANTES on the cell surface. (ox.ac.uk)
  • However, there is no data that indicates if and how patient-specific brain cells' intracellular milieus modulate protein aggregation. (biomedcentral.com)
  • Here, we studied changes in intracellular environment of PD patients' brain cells and how they modulate aSYN protein aggregation, using human induced pluripotent stem cells (hiPSC) and biochemical methods combined with infrared spectroscopy technique. (biomedcentral.com)
  • Our results establish a novel role for L-CaChs as important sources of the intracellular calcium necessary for the aggregation of AChRs. (nih.gov)
  • We sought to extend the receptor-desensitization paradigm for use with a cultured cell system, in which an intracellular calcium signal rather than a contractile response might be used as an index of receptor activation. (aspetjournals.org)
  • The above findings indicate that Reelin signaling is capable of inducing the formation of the dendrite-rich, cell-body-sparse MZ and a birthdate-dependent "inside-out" alignment of neurons independently of other factors/structures near the MZ. (jneurosci.org)
  • Neurons that arise in the adult nervous system originate from neural stem cells and neural progenitor cells. (elifesciences.org)
  • Neural stem cells can also give rise to neural progenitor cells, which proliferate rapidly during their short lives and then 'differentiate' into neurons or glia. (elifesciences.org)
  • Since neurosphere-forming cells can self-renew and differentiate into neurons and glia, the ability of cells to form neurospheres has generally been taken as evidence that they are stem cells. (elifesciences.org)
  • Researchers believe that the dynactin complex is particularly important for the proper function of axons, which are specialized extensions of nerve cells (neurons). (medlineplus.gov)
  • Slow or abnormal transport of materials needed for the normal function of neurons causes these cells to malfunction and ultimately die. (medlineplus.gov)
  • We developed a calcium signaling-based assay, using cultured human embryonic kidney cells (HEK), that evaluates simultaneously, the activation/desensitization or blockade of the proteinase-activated receptors, PAR 1 and PAR 2 . (aspetjournals.org)
  • The present study results indicated that compared with the same number of 2D-cultured cells, microtissue could secrete more nerve regeneration related cytokines to promote SCs proliferation and axons growth. (biomedcentral.com)
  • however, (Stx) that activates the signal pathway, leading to cell death humans of all ages can be affected. (cdc.gov)
  • Together with data obtained after treatment with various agents known to affect membrane organization in vitro , our findings suggest that a phosphorylation-controlled interaction between the cytoskeleton and the integral membrane protein band 3 is part of the membrane-centered mechanism that plays a role in deformability as well as aggregation. (frontiersin.org)
  • 2. The effects of GSNO and RIG200 in collagen (2.5 microg ml(-1))-induced platelet aggregation in PRP and whole blood were investigated in vitro. (uhi.ac.uk)
  • Notably, we performed a Thioflavin T (ThT)-based fluorescence assay to examine the effect of patient genome-induced changes in brain cells intracellular milieu on aggregation of recombinant p.A53T aSYN monomers. (biomedcentral.com)
  • Albumedix Ltd., an enabler of advanced therapies and the world leader in recombinant human albumin (rAlb), announced today that they have entered into a collaboration agreement with Cell and Gene Therapy Catapult (CGT Catapult) to investigate the use of Albumedix´ proprietary albumin-based solutions for advanced therapy applications, including viral vectors manufacturing. (news-medical.net)
  • Here, we analysed two deep mutational scanning experiments to investigate the role of protein aggregation in molecular evolution. (frontiersin.org)
  • Our study shows that aggregation is an important context-dependent constraint of molecular evolution and opens up new avenues to investigate the role of aggregation in the cell. (frontiersin.org)
  • Here, we investigate myricetin's potential as an inhibitor of IAPP aggregation. (openbiochemistryjournal.com)
  • Typically it shuttles between the nucleus and the cytoplasm to perform its functions, while abnormal cytoplasmic aggregation of TDP-43 has been associated with neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). (nature.com)
  • The molecular organization of the membrane of the red blood cell controls cell morphology and function and is thereby a main determinant of red blood cell homeostasis in the circulation. (frontiersin.org)
  • Studies of inborn errors of metabolism and membrane protein composition, in combination with the structural and functional changes that occur during RBC aging, have led to a membrane-centered molecular understanding of red blood cell function and survival, and of the role of membrane molecules in cell morphology and membrane organization. (frontiersin.org)
  • To address the potential interdependence of these two parameters, we measured deformation and aggregation in a variety of physiological as well as pathological conditions. (frontiersin.org)
  • As a first step, we correlated a number of deformability and aggregation parameters in red blood cells from healthy donors, which we obtained in the course of our studies on red blood cell homeostasis in health and disease. (frontiersin.org)
  • The correlation between the peripheral blood cells aggregation level measured by surface plasmon resonance method (SPR), and chromosomal abberations of peripheral blood lymphocytes in brain malignant gliomas patients was investigated. (rudn.ru)
  • Interestingly, NZ-1 neutralized platelet aggregation by LN319. (elsevierpure.com)
  • The prospect of improving manufacturing of viral vectors such as Adeno-associated virus (AAV) through this exciting technology is something which could significantly benefit and advance the wider cell and gene therapy field. (news-medical.net)
  • Results: Pretreatment with cilostazol significantly suppressed platelet-monocytic THP1 cell aggregation, P-selectin, and CD40L expression in a concentration-dependent manner at concentrations of 10 1 , 10 2 , and 10 3 mM, respectively. (tmu.edu.tw)
  • The presence of stress fibers, expressed as a-smooth muscle actin (SMA), in CeO2-exposed fibroblasts and ATII cells was significantly increased compared to the control. (cdc.gov)
  • Platelet aggregation and adherence to the bubble surface has been demonstrated in severe decompression sickness (DCS). (who.int)
  • Also, we found that most of these correlations were absent in misshapen red blood cells that have an inborn defect in the interaction between the membrane and the cytoskeleton. (frontiersin.org)
  • Recently, a body of evidence is growing that Aβ aggregation is facilitated in the presence of particular membranes lipids such as gangliosides and cholesterol and furthermore, that Aβ toxicities emerge through interaction with specific neuronal membrane microdomains such as lipid rafts. (hindawi.com)
  • These characterization techniques necessitate the elaboration of theoretical modeling (effective medium theory combined with the structure factor model, non-linear dynamic model) describing the interaction mechanisms wave-scatterers (wave-cells, wave-porous medium). (cnrs-mrs.fr)
  • Aggregation leads to a substantial increase in light transmission because of the formation of large particles and the concomitant clearing of the sample. (nature.com)
  • Given the double valence of protein aggregation that can result either in the formation of toxic assemblies or physiologically required organelles, it has long been debated what could determine whether aggregation is beneficial or detrimental from an evolutionary perspective. (frontiersin.org)
  • Neurosphere formation is commonly used as a surrogate for neural stem cell (NSC) function but the relationship between neurosphere-initiating cells (NICs) and NSCs remains unclear. (elifesciences.org)
  • Overall, our data suggest a prominent role for GAL3 in the aggregation process of αSYN and LB formation, leading to the production of short species to the detriment of larger strains which triggers neuronal degeneration in a mouse model of PD. (lu.se)
  • Axenic Biofilm Formation and Aggregation by Synechocystis sp. (bvsalud.org)
  • Xu, H, Salazar, DM & Xu, C 2022, ' Investigation of Cell Concentration Change and Cell Aggregation Due to Cell Sedimentation during Inkjet-Based Bioprinting of Cell-Laden Bioink ', Machines , pp. 315. (ttu.edu)
  • Unlike some other tissues, it has not been possible to identify or purify neural stem cells directly from the tissue. (elifesciences.org)
  • Tissue-engineered microtissue is an effective strategy for stem cell culture and therapy in nerve tissue engineering. (biomedcentral.com)
  • It is described as a housekeeping enzyme, being responsible for cell-to-cell signaling, tissue homeostasis, and cytoprotection. (medscape.com)
  • These studies yield the effects expected for poorly soluble particles in the rat on the alveolar macrophages, in cluding inflammation and increased cell proliferation. (europa.eu)
  • Lung fibroblasts and alveolar type II (ATII) cells isolated from CeO2-exposed rats at 28days post-exposure demonstrated decreasing proliferation rate when compare to the controls. (cdc.gov)
  • Consequently, neural stem and progenitor cells have usually been studied retrospectively, based on their ability to form colonies in laboratory cell cultures. (elifesciences.org)
  • A region of the brain called the subventricular zone contains both neural stem cells and neural progenitor cells, and is one of only two regions of the brain where neural stem cells are found in adult mammals. (elifesciences.org)
  • The investigators found that the resultant transfected cells showed defects in ATP2A2 protein expression (15 mutants), ATP hydrolysis (29 mutants), calcium transport (4 mutants), and calcium binding and kinetics (3 mutants). (medscape.com)
  • The observations suggest that deformability and aggregation share at least one common, membrane-related molecular mechanism. (frontiersin.org)
  • The observations show that the aggregation process in jaundice starts earlier, form compact structures which move faster initially and thus reducing the effective number of cells in the observation volume at all time intervals compared to that of normal suspensions. (iospress.com)
  • As nucleotides are released from cells under physiological and pathological conditions, they may play roles as intercellular signal molecules in neutrophil activation. (uni-regensburg.de)
  • Many if not all of these processes depend on the organization of the RBC membrane that enables the complex, dynamic interactions between the cell membrane and various intracellular and extracellular molecules. (frontiersin.org)
  • Preventing the initial aggregation event of IAPP is one strategy for slowing, and possibly preventing, the progression of this disease. (openbiochemistryjournal.com)
  • This region contains a glutamine/asparagine (Q/N) prion-like domain that participates in protein-protein interactions and in the TDP-43 aggregation process 4 , 5 . (nature.com)
  • This folding process is driven by the hydrophobic effect: a tendency for hydrophobic (water-fearing) portions of the protein to shield themselves from the hydrophilic (water-loving) environment of the cell by burying into the interior of the protein. (wikipedia.org)
  • The hypothesis that protein aggregation is a causative process in aging is testable now since some models of delayed aging are in hand. (wikipedia.org)
  • Usage Based Optimization is the process of defining aggregation design based on the actual queries executed by the users/applications accessing the cube, which is captured using a log. (mssqltips.com)
  • These findings provide a fundamental understanding of the molecular aggregation during the solution casting of non-fullerene organic solar cells. (rsc.org)
  • These findings open new perspectives for understanding the pathogenesis of protein aggregation in retinal cells and can be useful for the development of therapeutic treatments to prevent retinal cell deterioration. (tuni.fi)
  • Microaggregation appeared to be distinct from full aggregation, as it was not inhibited by the addition of CD61, an antibody to the β 3 integrin. (nature.com)
  • The microbial cells growing in a biofilm are physiologically distinct from planktonic cells of the same organism, which, by contrast, are single cells that may float or swim in a liquid medium. (wikipedia.org)
  • The role of membrane organization is prominently reflected in red blood cell deformation and aggregation. (frontiersin.org)
  • Epidemiological studies have suggested that subjects who develop ischaemic events have an elevation in their numbers of white blood cells. (dundee.ac.uk)
  • The blood samples were stimulated by adenosine diphosphate (8 μ M) for evaluation of platelet-monocytic THP1 cell aggregation and P-selectin expression and were stimulated by thrombin (0. (tmu.edu.tw)
  • 3. Neither compound inhibited aggregation in whole blood, even at concentrations of 100 microM. (uhi.ac.uk)
  • Blood samples for red blood cell counts (RBC), hematocrit (Hct), and PC were taken 1 h before and after exposure in two groups. (who.int)
  • This activation leads to platelet-monocyte aggregation, platelet P-selectin, and CD40 ligand (CD40L) expression. (tmu.edu.tw)
  • We aim to determine the effects of cilostazol on platelet activation as measured by platelet-monocyte aggregation, platelet P-selectin, and CD40L expression. (tmu.edu.tw)
  • In contrast to the wild type parental strain Sp7, strain Sp72002, a Tn5 induced flcA - mutant, does not aggregate, does not differentiate from motile, vibroid cells into nonmotile, cyst-like forms and lacks some of the exopolysaccharide material on its cell surface. (huji.ac.il)
  • Subpopulations of cells within the biofilm differentiate to perform various activities for motility, matrix production, and sporulation, supporting the overall success of the biofilm. (wikipedia.org)