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  • metabolism
  • Metabolism (from Greek: μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms. (wikipedia.org)
  • The word metabolism can also refer to the sum of all chemical reactions that occur in living organisms, including digestion and the transport of substances into and between different cells, in which case the set of reactions within the cells is called intermediary metabolism or intermediate metabolism. (wikipedia.org)
  • Amino acids also contribute to cellular energy metabolism by providing a carbon source for entry into the citric acid cycle (tricarboxylic acid cycle), especially when a primary source of energy, such as glucose, is scarce, or when cells undergo metabolic stress. (wikipedia.org)
  • tissues
  • 1. To investigate the expression of CYP1A1 messenger ribonucleic acid (mRNA) in endometriotic tissues and uterine endometrium from women with and without endometriosis throughout the menstrual cycle so as to determine whether C YP1A1 contribute to the pathogenesis of endometriosis. (cnki.net)
  • These compounds can be produced in cells and tissues of living organisms or in foods during processing or storage, and from these latter can be absorbed through the diet. (wikipedia.org)
  • As these molecules are vital for life, metabolic reactions either focus on making these molecules during the construction of cells and tissues, or by breaking them down and using them as a source of energy, by their digestion. (wikipedia.org)
  • miRNA research revealed different sets of miRNAs expressed in different cell types and tissues and multiple roles for miRNAs in plant and animal development and in many other biological processes. (wikipedia.org)
  • deregulation
  • We demonstrate a consistent deregulation of miRs in both monocytes and CD4 + T cells from axSpA patients, which could contribute to the pathophysiology of the disease with potential interest from a therapeutic perspective. (springer.com)
  • Gene
  • The nm23 gene transfection into murine melanoma cells. (buffalo.edu)
  • First identified in the conditioned media of human macrophage-like cells, HB-EGF is an 87-amino acid glycoprotein that displays highly regulated gene expression. (wikipedia.org)
  • Recent studies indicate significant HB-EGF gene expression elevation in a number of human cancers as well as cancer-derived cell lines. (wikipedia.org)
  • ERK is then able to enter the cell nucleus and control gene expression by phosphorylating various transcription factors, such as Elk-1. (wikipedia.org)
  • It is from there that the specific gene transcription occurs to initiate the cell cycle. (wikipedia.org)
  • molecule
  • Bis-(3´-5´)-cyclic dimeric guanosine monophosphate (c-di-GMP) is a soluble molecule that functions as a secondary messenger in bacterial cells. (news-medical.net)
  • B7-H1, a co-inhibitory molecule of the B7 family, is found aberrantly expressed in ovarian cancer cells and infiltrating macrophage/dendritic-like cells, and plays a critical role in immune evasion by ovarian cancer. (jove.com)
  • For example, IQGAP1 expression is necessary for neuronal process outgrowth on the cell adhesion molecule PTPmu (PTPRM). (wikipedia.org)
  • This molecule releases RUNX1 from CBFβ-SMHHC specifically and restores the RUNX1 transcriptional program in inv(16) positive human leukemic cells. (wikipedia.org)
  • expression
  • Objective (1) To profile the protein expression of TGF 1 and its receptors in cycling and early pregnant endometrium, and to evaluate the biological effects of TGF 1 on uterine endometrium , the window of implantation and its relation with unexplained infertility. (cnki.net)
  • Results:①The expression of COX-2 mRNA and protein in normal endometria was relevant to the phase of the menstrual cycle,secretory phase were higher than proliferative phase(P<0.05). (cnki.net)
  • The expression of FBXO5 and FBXO45 was elevated in squamous lung cancer cell lines than lung adenocarcinoma cell lines (GSE57083, S4A). (springer.com)
  • Protein expression of FBXO5 and FBXO45 in cell lines was shown in S4B. (springer.com)
  • Expression analysis has also indicated that IQGAP1 is overexpressed in many cancers, and in more aggressive colorectal and ovarian cancers, IQGAP1 is localized at the invasive front of the neoplasm, indicating a role in mobilization of the cells. (wikipedia.org)
  • Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. (wikipedia.org)
  • Both in vivo and in vitro studies of tumor formation in cancer dervived cell lines indicate that expression of HB-EGF is essential for tumor development. (wikipedia.org)
  • Schwann cells show high expression of PMP22, where it can constitute 2-5% of total protein content in compact myelin. (wikipedia.org)
  • When Schwann cells come into contact with a neuronal axon, expression of PMP22 is significantly up-regulated, whereas PMP22 is down-regulated during axonal degeneration or transection. (wikipedia.org)
  • lung carcinoma
  • Particularly if pigmented and located posteriorly, in the case of nonsmall-cell lung carcinoma cells in the genomes of high-risk hpv types are as follows: 1. (buffalo.edu)
  • cytoskeletal
  • At the cellular level, RhoA/ROCK mediates cytoskeletal rearrangement in renal tubule cells, mesangial cells and podocytes and may contribute to epithelial-mesenchymal transdifferentiation, which may be important in the development of renal fibrosis. (diabetesjournals.org)
  • Members of this superfamily appear to regulate a diverse array of cellular events, including the control of GLUT4 translocation to glucose uptake, cell growth, cytoskeletal reorganization, antimicrobial cytotoxicity, and the activation of protein kinases. (wikipedia.org)
  • Transcription
  • In AGS cells, the effect of H. pylori infection on base excision repair and mismatch repair (MMR) was analyzed by reverse transcription-PCR, Western blot, and activity assays. (aacrjournals.org)
  • RhoA
  • RhoA translocation has also been observed in mesangial cells exposed to high glucose in vitro ( 6 ). (diabetesjournals.org)
  • The specificity of the in vivo findings was confirmed in vitro where both Y-27632, another ROCK inhibitor, and dominant-negative RhoA decreased type IV collagen accumulation in mesangial cells exposed to high glucose. (diabetesjournals.org)
  • epiboly
  • The extent to which epiboly is driven by forces pulling the EVL downwards compared with the expansion forces of the deep cells is still unclear. (biologists.org)
  • formation
  • A recent paper in Development reveals that the Hippo pathway effector Taz directs the formation of the micropylar cell, a unique enlarged follicle cell in the ovary, and hence is crucial for fertility. (biologists.org)
  • Although the PMP22 mechanism of action in myelinating Schwann cells is not fully known, it plays an essential role in the formation and maintenance of compact myelin. (wikipedia.org)
  • control
  • Skp2 is the substrate recruiting component of the SCFSkp2 complex, which targets cell cycle control elements, such as p27 and p21. (wikipedia.org)
  • Here, SKP2 has been implicated in double negative feedback loops with both p21 and p27, that control cell cycle entry and G1/S transition. (wikipedia.org)
  • intracellular
  • These enzymes have low Km values for HNE catalysis and together are very efficient at controlling the intracellular concentration, up to a critical threshold amount, at which these enzymes are overwhelmed and cell death is inevitable. (wikipedia.org)
  • squamous
  • Specifically, zalutumumab is designed for the treatment of squamous cell carcinoma of the head and neck (SCCHN), a type of cancer. (wikipedia.org)
  • oncogene
  • Skp2 behaves as an oncogene in cell systems and is an established protooncogene causally involved in the pathogenesis of lymphomas. (wikipedia.org)
  • roles
  • Activating or gain-of-function mutations of Rac1 are shown to play active roles in promoting mesenchymal-type of cell movement assisted by NEDD9 and DOCK3 protein complex. (wikipedia.org)
  • Drosophila
  • It has been possible to express uPAR recombinantly in CHO-cells and S2 cells from Drosophila melanogaster. (wikipedia.org)
  • A year later, the lin-4 and let-7 RNAs were found to be part of a large class of small RNAs present in C. elegans, Drosophila and human cells. (wikipedia.org)
  • viability
  • AI-10-49 reduced viability and colony forming ability of human primary inv(16) leukemic blast cells, without affecting normal human bone marrow cells as wells non- inv(16) primary human leukemic blast cells. (wikipedia.org)
  • enzymes
  • Modifications to these GAG chains by several different families of enzymes epimerize ring structures, add sulfates and remove acetylases in a non-template-driven fashion, resulting in variable regions of sulfation on each GAG chain and creating an astonishing level of complexity within one cell-surface HSPG. (biologists.org)
  • A small group of enzymes are specifically suited to the detoxification and removal of 4-HNE from cells. (wikipedia.org)
  • melanoma
  • Rac1 protein is also necessary for glucose uptake in skeletal muscle activated by exercise and muscle stretching Activating mutations in Rac1 have been recently discovered in large-scale genomic studies involving melanoma and non-small cell lung cancer. (wikipedia.org)
  • vitro
  • In fact, FAK immunoprecipitated from metabolically-labelled mitotic HeLa cells without tyrosine phosphatase inhibitors was phosphorylated on Ser only and was dephosphorylated in vitro by purified muscle PP1, with loss of phospho-Ser. (biochemj.org)
  • FAK obtained from cells at 1.5h was Ser-phosphorylated, and underwent dephosphorylation during in vitro incubation, with loss of phospho-Ser, indicating the presence of active FAK-bound phosphatase. (biochemj.org)
  • monocytes
  • CD14 + monocytes and CD4 + T lymphocytes were isolated from peripheral blood mononuclear cells. (springer.com)
  • HB-EGF displays target cell specificity during the early stages of wound healing being released by macrophages, monocytes, and keratinoctyes. (wikipedia.org)