Cell cell adhesion adhesion receptors laminin. Medical search. Frequent questions

They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. (wikipedia.org)
By a yeast two-hybrid approach, we identified an interaction between the AChE and an 898 bp fragment of laminin-beta1 chain, an extracellular matrix protein involved in neuronal differentiation and adhesion processes. (tu-darmstadt.de)
Laminin G-containing proteins appear to have a wide variety of roles in cell adhesion, signalling, migration, assembly and differentiation. (embl.de)
A universal feature is the generation of a dense and highly rigid stromal extracellular matrix (ECM) that, based on analyses of the adhesion-dependent control of cell phenotype in other systems, is likely to alter proliferation, migration and differentiation. (manchester.ac.uk)
Through interactions with cell surface receptors, laminins stimulate intracellular signaling cascades which direct specific survival and differentiation outcomes. (bvsalud.org)
The composition of extracellular matrix (ECM) is tissue specific, however, its functions with respect to cellular adhesion, communication, and differentiation remain uniform irrespective of the change in composition. (biologywise.com)
This is one of the reasons why serum itself - or an animal-free equivalent - is so important for cell growth and differentiation. (capricorn-scientific.com)
This family, which includes epidermal growth factor receptor (EGFR), plays a pivotal role in normal cell growth, lineage determination, repair, and functional differentiation. (medscape.com)
Laminin is an extracellular matrix multidomain trimeric glycoprotein and is the main non-collagenous component of basal lamina that supports adhesion, proliferation and differentiation. (sigmaaldrich.com)
The ECM composed of hundred proteins is a dynamic network controlling the proliferation, adhesion, migration, polarity, differentiation, and apoptosis of the cells. (premiumbeautynews.com)
In order to be effective and integrated to the receiving area, the bone graft is required to allow a strong cell adhesion, interacting with several molecules to induce migration, differentiation, and thus the mineralization of the new bone on the graft. (bvsalud.org)
Notwithstanding, to achieve the effectiveness and integration of the grafted tissue to the receptor site, it is necessary a strong cell adhesion, so that it demands many molecules interaction to induce cell differentiation and the bone matrix mineralization formed onto the graft. (bvsalud.org)

Indeed, granule cells from the rostral region of perinatal Gpr56 −/− cerebella show loss of adhesion to extracellular matrix molecules of the pial basement membrane. (jneurosci.org)
These studies establish a novel role for GPR56 in the adhesion of developing neurons to basal lamina molecules and suggest that this adhesion is critical for maintenance of the pia and proper cerebellar morphogenesis. (jneurosci.org)
Consistent with this hypothesis, developing granule cells from the rostral region of Gpr56 −/− cerebella at birth exhibit a specific defect in cell adhesion to extracellular matrix (ECM) molecules of the pial basement membrane (BM) but no defects in migration, proliferation, or process outgrowth. (jneurosci.org)
Moreover, integrins, laminins, NF-κB and other regulative molecules were found as crucial proteins. (nature.com)
The existence of multiple molecular forms, the homology with other neuronal cell adhesion molecules, and the early expression pattern, suggest that AChE may function in cell adhesion, and thus in neurite growth, guidance and even synaptogenesis. (tu-darmstadt.de)
CD49a is also known as very late antigen 1α subunit (VLA-1) of the integrin family of cell adhesion molecules. (bdbiosciences.com)
We hope then to perturb the function of candidate molecules in organoids using knockdown and pharmacological inhibition, and employ molecular cell biology approaches to pinpoint how the sensory mechanisms vary between wild type (WT) and tumour cells. (manchester.ac.uk)
This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. (utsouthwestern.edu)
It not only functions as a physical scaffolding, but also provides a channel for the migration and communication of cells via the use of signaling molecules. (biologywise.com)
The cells embedded within it interact with the matrix as well as with other cells due to the presence of specialized matrix receptor molecules. (biologywise.com)
These molecules interact with the matrix as well as the internal processes of the cell, thereby, bringing about cellular exchange of signals. (biologywise.com)
Protein bridges, also called substrate adhesion molecules, have receptors on the cell side, as well as adhesion molecules on the substrate side. (capricorn-scientific.com)
Some adhesion molecules are synthesized by the cell, but most of them are derived from serum . (capricorn-scientific.com)
Various techniques have been developed for targeting cancer cells: gene therapy, monoclonal antibodies (MAbs), antibody toxin conjugates, small-molecule inhibitors, antisense molecules, and tumor vaccines. (medscape.com)
Redirecting endogenous antibodies in the bloodstream to tumor cells utilizing artificial molecules is a promising strategy to set off anti-tumor immune responses. (kashbiotech.com)
Otiz-Urda and colleagues (7) showed the development of human being epidermal squamous cell carcinomas required the interaction between the two extracellular matrix molecules laminin 332 (LM332) and type VII collagen and recent studies show that this interaction is definitely mediated by signaling through integrin mediated adhesions. (monossabios.com)
For traveling, cells first need to be attached to some element of the environment, a cell or some molecules of the extracellular matrix, and then drag the nucleus and the rest of the cytoplasm in the direction of moving. (uvigo.es)
One adhesion molecule does not make a strong bond, but cell adhesion is performed by many adhesion molecules that altogether make a strong linking, as if they were a molecular Velcro. (uvigo.es)
Some adhesion molecules may interact laterally between each other and form molecular complexes that increase the adhesion strength in some local points of the cell surface. (uvigo.es)
For example, cells can change the type and amount of adhesion molecules in the plasma membrane by synthesis, degradation, or hidden them temporarily in internal compartments by endocytosis and exocytosis. (uvigo.es)
Another mechanism to control the strength and specificity of adhesion is by activating or inactivating the adhesion molecules in the plasma membrane. (uvigo.es)
T here are adhesion molecules involved in the attachment of cells to the extracellular matrix and others in linking one cell to another. (uvigo.es)
In general, the adhesion strength of integrins is weaker than that of other adhesion molecules. (uvigo.es)
This "renowned" matrix plays one of the essential roles of the physical and biomechanical properties of the dermis with this intricate network of extracellular macromolecules providing cells structural, bioactive molecules and biochemical support. (premiumbeautynews.com)
These cell adhesion molecules (CAM) will mediate the contact between two cells or between cells and the extracellular matrix, an essential process to the success of the implant. (bvsalud.org)
This paper is a systematic review of the literature on the mechanisms of cell adhesion to bone grafts associated to nanotechnology, describing the importance and the role of those molecules in the adhesion and thus in tissue regeneration. (bvsalud.org)
The main reported mechanisms involve cell adhesion molecules (CAMs) and extracellular matrix components. (bvsalud.org)
Several molecules are involved in the process of cell adhesion to bone grafts, highlighting the role of integrins, the focal adhesion mechanism, the influence of the collagen matrix, and the activity of alkaline phosphatase in bone matrix formation. (bvsalud.org)
Tissue engineering is a strategy very used to obtain functional repairing through the development of biological substitutes that can restore, keep or substitute damaged tissues or organs 31 , through the combination of scaffolds biocompatible with live cells and/or bioactive molecules 19 . (bvsalud.org)
Some of these molecules are glycoproteins expressed on the cell surface, socalled cell adhesion molecules (CAM), which mediate either the contact between two cells or the contact among cells and the extracellular matrix, being therefore of fundamental importance for adhesion 3 . (bvsalud.org)

GO analysis shows that the differential abundant proteins are associated with cell junction and signal transducer activity from extracellular to intracellular. (nature.com)
To gain an insight into the noncholinergic, cell adhesion promoting functions of acetylcholinesterase, we sought proteins interacting with it. (tu-darmstadt.de)
The laminin globular (G) domain can be found in one to several copies in various laminin family members, including a large number of extracellular proteins. (embl.de)
Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C. The Journal of cell biology, 223-232. (antibodiesinc.com)
The plectin repeat is also seen in the cell adhesion junction plaque proteins, desmoplakin, envoplakin, and bullous pemphigoid antigen. (embl.de)
We hope therefore to answer fundamental questions about the proteins that control normal cell behaviour, how these proteins are altered in disease, and how these changes convert normal cells into cancer cells. (manchester.ac.uk)
Fibrosis is characterised by an excessive production of extracellular matrix components, and cells in the tissue are constantly interacting with these extracellular matrix proteins. (bmj.com)
Laminins are alphabetagamma heterotrimeric extracellular proteins that regulate cellular functions by adhesion to integrin and nonintegrin receptors. (ox.ac.uk)
Adhesion of CD34(+)CD38(-) cells to laminin-10/11 was maximal without integrin activation, whereas adhesion to other proteins was dependent on protein kinase C activation by 12-tetradecanoyl phorbol-13-acetate (TPA). (ox.ac.uk)
Explore our solutions for multiple applications - vaccines, monoclonal antibodies, recombinant proteins, cell or gene therapy. (vwr.com)
A heterogeneous family of water-soluble structural proteins found in cells of the vertebrate lens. (lookformedical.com)
This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. (utsouthwestern.edu)
PHD2 is certainly the major prolyl hydroxylase that adjusts HIF-1 proteins balance in nonhypoxic cells, whereas knockdown of PHD1 or PHD3 will not really affect HIF-1 proteins amounts in many tumor cell lines (Berra range 350C1700 at a quality of 30,000. (forgetmenotinitiative.org)
Co-IP assays Cells had been lysed in altered radioimmunoprecipitation assay stream, and WCLs had been incubated over night with anti-FLAG (Sigma-Aldrich, St. Louis, MO), anti-PHD2 (Novus Biologicals, Littleton, Company), anti-PHD3 (Novus Biologicals), or anti-hydroxyproline (Abcam) antibody in the existence of proteins ACagarose beans (Novus Biologicals). (forgetmenotinitiative.org)
Laminins are extracellular matrix proteins that reside in the basement membrane and provide structural support in addition to promoting cellular adhesion and migration. (bvsalud.org)
It breaks down the anchorage proteins that attach the cell to the culture vessel. (capricorn-scientific.com)
Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. (cancer-genetics.org)
The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. (cancer-genetics.org)
This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. (cancer-genetics.org)
Using mass spectrometry, quantitative proteomic analysis and Gene Ontology terms filters, we observed that EVs released by EGFRvIII-transformed cells were enriched for extracellular exosome and focal adhesion related proteins. (cancer-genetics.org)
Among them, we validated the association of pro-invasive proteins (CD44, BSG, CD151) with EVs of EGFRvIII expressing glioma cells, and downregulation of exosomal markers (CD81 and CD82) relative to EVs of EGFRvIII-negative cells. (cancer-genetics.org)
Nano-flow cytometry revealed that the EV output from individual glioma cell lines was highly heterogeneous, such that only a fraction of vesicles contained specific proteins (including EGFRvIII). (cancer-genetics.org)
Cell adhesion relies on transmembrane proteins, known as adhesion proteins , found in the plasma membrane. (uvigo.es)
In fact, adhesion proteins are very similar when comparing the different animal groups, including marine sponges. (uvigo.es)
I ntegrins are probably the most important proteins involved in the adhesion of cells to the extracellular matrix, and comprise a large family of transmembrane proteins present in all animals. (uvigo.es)
Laminin proteins are integral components of structural scaffolding in animal tissues. (sigmaaldrich.com)
These properties will act mediating the action of cell adhesion proteins, regulating cell behavior and causing tissue regeneration. (bvsalud.org)
To occur the adhesion of CAMs to the biomaterial, it is necessary their interaction with some components of extracellular matrix, such as proteoglycans, collagen and proteins 23 . (bvsalud.org)

CD49a associates with the integrin β1 subunit (CD29) to form the α1/β1 heterodimer (CD49a/CD29), and serves as receptor for collagen and laminin-1. (bdbiosciences.com)
Laminin peptide YIGSR induces collagen synthesis in Hs27 human dermal fibroblasts. (peptide.com)
According to subsequent experiments, we found that the YIGSR peptide strongly enhanced collagen type 1 synthesis without changing cell proliferation or cellular MMP-1 level. (peptide.com)
Deposition of collagen and proliferation of smooth muscle cells are the response to chronic inflammation and injury of the submucosa leading to fibrosis and thickening of the submucosa and the smooth muscle layers of the bowel wall. (bmj.com)
Ligands for integrins include fibronectin, vitronectin, collagen and laminin. (biomaterialsusa.com)
An intracellular domain that interacts with actin filaments of the cytoskeleton (sometimes with intermediate filaments), an extracellular domain that binds collagen, fibronectins and laminins, and an intramembrane domain containing hydrophobic amino acid sequences inserted among the lipid fatty acid chains. (uvigo.es)
They associate with type IV collagen via entactin and perlecan and bind to cell membranes through integrin receptors, dystroglycan glycoprotein complexes and Lutheran blood group glycoproteins. (sigmaaldrich.com)
Laminin has active domains for collagen binding, cell adhesion, heparin binding, and neurite outgrowth fragment. (sigmaaldrich.com)

Plectin binds to hemidesmosomes through association of its actin-binding domain with the first pair of fibronectin type III repeats and a small part of the connecting segment of the integrin-beta4 subunit, the latter (integrin-alpha6,beta4) acting as a receptor for the extracellular matrix component laminin-5. (embl.de)
No colocalisation of mast cells was found with fibronectin or vitronectin. (bmj.com)
We studied human bone marrow cell adhesion to laminin-10/11 (alpha5beta1gamma1/alpha5beta2gamma1), laminin-8 (alpha4beta1gamma1), laminin-1 (alpha1beta1gamma1), and fibronectin. (ox.ac.uk)
About 35% to 40% of CD34(+) and CD34(+)CD38(-) stem and progenitor cells adhered to laminin-10/11, and 45% to 50% adhered to fibronectin, whereas they adhered less to laminin-8 and laminin-1. (ox.ac.uk)

Plectin is recruited into hemidesmosomes, multiprotein complexes that facilitate adhesion of epithelia to the basement membrane, thereby providing linkage between the intracellular keratin filaments to the laminins of the extracellular matrix. (embl.de)
The ductal system is coated by a chain of luminal epithelial cells (LECs) situated on a layer of myoepithelial cells (MECs) and encompassed by a distinguished basement membrane. (biomedcentral.com)
Two major cell types cooperate to build up the ductal units: inner polarized luminal epithelial cells (LECs) embraced by a layer of myoepithelial cells (MECs), both cell types are rimmed by a cohesive basement membrane (BM) [ 2 ]. (biomedcentral.com)
Laminins are multifunctional basement membrane glycoproteins composed of a, b, and g polypeptide chains. (mirnamimic.com)
It is localized in the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. (bvsalud.org)

Loss of GPR56 does not affect cell proliferation, migration, or neurite outgrowth. (jneurosci.org)
Cells expressing stem cell markers, including GFAP, and proliferation markers are closely apposed to the laminin-containing extracellular matrix (ECM) surrounding vascular endothelial cells. (nih.gov)
Adult SVZ progenitor cells express the laminin receptor alpha6beta1 integrin, and blocking this inhibits their adhesion to endothelial cells, altering their position and proliferation in vivo, indicating that it plays a functional role in binding SVZ stem cells within the vascular niche. (nih.gov)
Determination of the mechanisms whereby rigidity influences cell proliferation. (manchester.ac.uk)
The outcomes of the programme will advance our understanding of cancer in two ways: by defining how the adhesive stromal microenvironment influences tumour cell proliferation, and by identifying potential clinical targets in a cancer of massive unmet need. (manchester.ac.uk)
For several decades, neovascularization is believed to be accomplished by proliferation of mature endothelial cells residing in the local vessels through the process of angiogenesis [ 6 ]. (hindawi.com)
This matrix lends structural as well as biochemical support to the cells surrounded by it, and forms a foundation for their growth and proliferation. (biologywise.com)
It consists of a variety of growth and differentiating factors that regulate and influence development, migration, proliferation, shape, and metabolic functions of the cells. (biologywise.com)
Responses in LSL indicated altered proliferation rates of intestinal cells as well as adaptive responses at the level of paracellular transport and immunocompetence. (biomedcentral.com)
Sufficient dietary supply of calcium (Ca) and phosphorus (P) is essential for all vertebrates to ensure various biological processes including bone formation, blood clotting, cell proliferation and energy metabolism. (biomedcentral.com)

Synthetic peptides from the carboxy-terminal globular domain of the A chain of laminin: their ability to promote cell adhesion and neurite outgrowth, and interact with heparin and the beta 1 integrin subunit. (rupress.org)
residues 2,110-3,060) of the A chain of murine-derived laminin has been shown to promote heparin binding, cell adhesion, and neurite outgrowth. (rupress.org)
Antibodies against the beta 1 integrin subunit inhibited HT-1080 cell adhesion and neurite outgrowth on surfaces adsorbed with peptides GD-3 and GD-4. (rupress.org)
To further examine the effect of gene dosage of ZNF804A on neurite morphology, both knockdown and overexpression of ZNF804A in primary neuronal cells significantly attenuate dendritic complex and spine formation. (biomedcentral.com)
Synthetic peptides or recombinant fragments containing bio- logically active motifs have been shown to partially mimic the effects of native laminin in various cellular functions, such as cell adhesion, spreading, migration, neurite outgrowth, and tumor metastasis [6-10], suggesting that laminin-derived-short peptide- modified biomaterials may have therapeutic potential in tissue regeneration applications. (mirnamimic.com)

The process of metastasis is the consequence of migration of melanoma cells from the primary lesion, to locoregional and distant body sites via the lymphatic circulation and the bloodstream. (hindawi.com)
Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells. (ox.ac.uk)
The cell-adhesive laminins affected migration of hematopoietic progenitors, suggesting a physiologic role for laminins during hematopoiesis. (ox.ac.uk)
Laminin subunit beta 1 (LAMB1) is involved in attachment, migration, and organization during development, and its elevated expression has been associated with several cancers. (bvsalud.org)
PKC activation by phorbol myristate acetate has been shown to induce the adhesion, spreading, and migration of cells [12]. (mirnamimic.com)
Syndecan-1 (sdc-1) is a cell surface proteoglycan that mediates the connection of cells with their matrix, influencing attachment, migration and response to growth factors. (monossabios.com)
In contrast, sdc-1 null fibroblasts display increased rates of cell migration. (monossabios.com)

Laminin subunit gamma-3 also known as LAMC3 is a protein that in humans is encoded by the LAMC3 gene. (wikipedia.org)
Each laminin chain is a multidomain protein encoded by a distinct gene. (wikipedia.org)
Mutations in GPR56 , an orphan G-protein-coupled receptor (GPCR), cause bilateral frontoparietal polymicrogyria (BFPP), a disorder characterized by mental retardation, seizures, motor developmental delay, and ataxia. (jneurosci.org)
KEGG pathways enrichment and PPI network indicate four major pathways, including extracellular matrix -receptor interaction, focal adhesion, phosphatidylinositol 3-kinase (PI3K)-Protein kinase B (Akt), and Ras signaling pathways were involved in the degeneration of cartilage. (nature.com)
Using a new method for construction and database searches of sequence consensus strings, we have identified a new superfamily of protein modules comprising laminin G, thrombospondin N and the pentraxin families. (embl.de)
Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons. (antibodiesinc.com)
An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. (lookformedical.com)
Important biological events associated with plasma membranes, such as signal transduction, cell adhesion, and protein trafficking, are mediated through the membrane microdomains. (mdpi.com)
In most cases, the cultivation surface has a negative charge and adhesion is believed to be mediated by protein bridges or ionic interactions (e.g., via Ca 2+ ). (capricorn-scientific.com)
Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)
This protein enhances cell motility, invasion and metastasis of cancer cells. (cancer-genetics.org)
Currently, 18 subtypes have been reported: 12 are type I (dysfunctional lipid-linked oligosaccharide precursor synthesis), and 6 are type II (dysfunctional trimming/processing of the protein-bound oligosaccharide), including leukocyte adhesion deficiency II (CDG-IIc). (medscape.com)
P-selectin, soluble endothelial protein C receptor, soluble thrombomodulin, plasminogen activator inhibitor 1, ADAMTS-13, von Willebrand factor, tissue factor, soluble intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 were more elevated in LF patients than in controls. (cdc.gov)
Endothelial protein C receptor, thrombomodulin, intercellular adhesion molecule 1, plasminogen activator inhibitor 1, D-dimer, and hepatocyte growth factor were higher in fatal than nonfatal LF cases. (cdc.gov)

Furthermore, these results suggest that the sequences comprising peptides GD-3 and GD-4 use an integrin as a receptor, of which the beta 1 integrin subunit is a component for these various cell types. (rupress.org)
Cells, in turn, may regulate the strength of adhesion by increasing or decreasing the number of integrins, by synthesizing different integrin subunit subtypes, or by changing the adhesion affinity after modulation of the intracellular domain, which in turn will modify the adhesion ability of the extracellular domain. (uvigo.es)
Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)

In the case of melanoma, circulating cells may find a suitable microenvironment in the first draining lymph node, known as the sentinel lymph node, in other lymphnodes or in distant organs, leading to secondary tumor growth (Figure 1 ). (hindawi.com)
The laminin tyrosine-isoleucine-glycine-serine-arginine (YIGSR) peptide, corresponding to the 929-933 sequence of the Î²1 chain, is known to be a functional motif with effects on the inhibition of tumor metastasis, the regulation of sensory axonal response and the inhibition of angiogenesis through high affinity to the 67 kDa laminin receptor. (peptide.com)
Emerging techniques using the analysis of circulating tumor cells show promising results in predicting and identifying the early stages of breast cancer metastasis in patients. (iiarjournals.org)
An emerging method to detect metastasis is the analysis of circulating tumor cells (CTCs), which has shown promise in filling the gaps left by other diagnostic methods. (iiarjournals.org)
CTCs are tumor cells originating from primary sites or metastases that circulate in the patients' bloodstream and are very rarely found in healthy individuals ( 9 , 10 ) ( Figure 1 ). (iiarjournals.org)
Morphological-based isolation separates CTCs according to size discrepancies, using isolation by size of epithelial tumor cells (ISET) or according to density, using density-gradient separation ( 4 ). (iiarjournals.org)
This method uses either epithelial cell-specific markers which are generally expressed in all tumor cells, or tumor markers expressed by specific types of cancer ( 13 ). (iiarjournals.org)
Circulating tumor cells in the blood stream. (iiarjournals.org)
The HER (erbB) family of transmembrane receptor tyrosine kinases is one of the cytostatic targets in tumor cell growth and survival. (medscape.com)
This task can be accomplished by replacing tumor suppressor genes that have been lost or mutated, selectively inserting genes that produce cytotoxic substances, or modifying the immune system to destroy the tumor cells. (medscape.com)
EGFRvIII impacts both cell-intrinsic and non-cell autonomous aspects of GBM progression, including cell invasion, angiogenesis and modulation of the tumor microenvironment. (cancer-genetics.org)
Here we analyzed the impact of EGFRvIII on the profile of glioma EVs using isogenic tumor cell lines, in which this oncogene exhibits a strong transforming activity. (cancer-genetics.org)
This laminin product was isolated from mouse Engelbreth-Holm-Swarm tumor. (sigmaaldrich.com)
Immune cells with peripheral origin pass through the damaged blood-brain barrier (BBB) and release cytokines, including tumor necrosis factor alpha (TNFα), interferon gamma (IFN-γ), and interleukin 17 (Il-17). (encyclopedia.pub)

We studied the secretome profile of gestational tissue-derived MSCs and their effects on functions of endothelial progenitor cells (EPCs), another angiogenic cell type that plays an important role during the neovascularization. (hindawi.com)
Mesenchymal stem cells (MSCs) are multipotent stem/progenitor cells which can differentiate to several mesodermal derivatives and possess an ability to secrete factors involved in neovascularization and immunomodulation [ 1 , 2 ]. (hindawi.com)
However, recent studies have demonstrated that other angiogenic cells called endothelial progenitor cells (EPCs) also play an important role during the formation of new vessels through the process of vasculogenesis [ 7 - 9 ]. (hindawi.com)
Laminin-10/11 was highly adhesive to lineage-committed myelomonocytic and erythroid progenitor cells and most lymphoid and myeloid cell lines studied, whereas laminin-8 was less adhesive. (ox.ac.uk)
The density of OL progenitor cells (OPCs), the main cell population remyelinating axons, increases in early MS lesions compared to the adjacent NAWM, which sustains mature OL populations with unaltered density. (encyclopedia.pub)

Integrins are receptors that facilitate cell-extracellular matrix (ECM) adhesion. (biomaterialsusa.com)
Several types of integrins exist, and one cell may have multiple different types on its surface. (biomaterialsusa.com)
We provide a complete integrin binding peptide array to help researchers to quickly identify the types of integrins on the cell surface. (biomaterialsusa.com)
The region of sdc-1 that associates with 31 and 64 integrins is called the co-receptor binding website. (monossabios.com)
The latent website of AG-1478 enzyme inhibitor TGF1 has an v integrin binding site and studies have suggested that v integrins sequester latent TGF1 to the cell surface and control its activation locally (11). (monossabios.com)
By combination, they are able to form up to 24 different integrins, which are differentially expressed depending on the tissue and the physiological state of the cell. (uvigo.es)
The ability of integrins to mechanically connect extracellular matrix and cytoskeleton allows the structural continuity between the internal and external environments of the cell. (uvigo.es)
Furthermore, integrins may change the behavior of the cell according to the molecular composition of the extracellular matrix (they behave like receptors). (uvigo.es)
This is possible because the adhesion state of integrins is transmitted to their intracellular domain by conformational change, triggering molecular interaction cascades in the cytosol, that eventually change gene expression. (uvigo.es)
The strength of the adhesion of a cell to the extracellular matrix depends on the number, the active state and type of integrins that are expressed in the plasma membrane. (uvigo.es)

In experiments probing for a role of PKCa in human laminin-2-integrin-mediated cell adhesion and spreading of PC12 cells, we observed unexpected enhancements of adhesion, spreading and stress fiber formation to 1 mM Go¨6976 with concomitant increase in membrane translocation of PKCd and autophosphorylation of focal adhesion kinase (FAK). (mirnamimic.com)
Pharmacologic blockade of PKC inhibits cell adhesion and spreading as well as focal adhesion formation and focal adhesion kinase (FAK) phosphorylation [13,14]. (mirnamimic.com)

Structural features of Caspr2 include epidermal growth factor repeats, laminin G domains, F5/8 type C domain, fibrinogen-like domains, and PDZ binding sites. (antibodiesinc.com)
Glioblastoma multiforme (GBM) is a highly aggressive and heterogeneous form of primary brain tumors, driven by a complex repertoire of oncogenic alterations, including the constitutively active epidermal growth factor receptor (EGFRvIII). (cancer-genetics.org)

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. (wikipedia.org)

This review focuses on the research to date detailing the expression of laminin isoforms, their potential function, as well as known pathways involved in laminin signaling in metabolic tissues. (bvsalud.org)

However, it was also found that the gamma 3 is a prominent element of the apical surface of ciliated epithelial cells of lung, oviduct, epididymis, ductus deferens, and seminiferous tubules. (wikipedia.org)
Therefore, damaging the MECs layer resulted in the release of various factors (such as SDF1/CXCL12, CXCL14, MMP, and tenascin) [ 11 , 12 ] with a potential to modify the tumour microenvironment and facilitate the paracrine communication between the tumour epithelial cells and the enclosed stroma enhancing the tumour aggressiveness [ 11 , 13 ]. (biomedcentral.com)
Evidence for the importance of sdc-1 in epithelial homeostasis is definitely shown by the fact that sdc-1 manifestation in epithelial cells is definitely controlled via TGF1 mediated cell signaling AG-1478 enzyme inhibitor (16). (monossabios.com)
It is critical that we develop a more complete understanding of the dual nature of the cell signaling events controlled by both sdc-1 and TGF1 in epithelial cells. (monossabios.com)

To find better therapies, patient-specific models that mimic the biology of tumour tissues and interactions between different cell types are developed. (ipfdd.de)
Therapeutic potentials of mesenchymal stem cells (MSCs) depend largely on their ability to secrete cytokines or factors that modulate immune response, enhance cell survival, and induce neovascularization in the target tissues. (hindawi.com)
The aim of this study was to investigate whether mast cells accumulate in these tissues and whether their localisation is associated with extracellular matrix components. (bmj.com)
It acts as a cell adhesion receptor in both muscle and non-muscle tissues. (absoluteantibody.com)
In metabolic tissues such as the pancreas, adipose, muscle, and liver, laminin isoforms are expressed in discrete temporal and spatial patterns suggesting that certain isoforms may support the development and function of particular metabolic cell types. (bvsalud.org)
We will also discuss the current biomedical therapies involving laminins in these tissues in addition to prospective applications, with the goal being to encourage future investigation of laminins in the context of metabolic disease. (bvsalud.org)
Here, we determined that LAMB1 is upregulated in gastric cancer tissues and contributes to cell growth and motility. (bvsalud.org)
Extracellular matrix is the extracellular, complex mixture of various biomolecules and fibers secreted by cells in the tissues of multicellular organisms. (biologywise.com)
C ells move through tissues by way of adhesion. (uvigo.es)

The results show that AChE-positive cells in the retina also coexpress neurexin, with AChE preceding neurexin (~48h). (tu-darmstadt.de)

It is involved in mediating cell-cell interactions in the nervous system and involved in neural-glia interactions and clustering of potassium channels in myelinated axons. (antibodiesinc.com)
While the function of CD57 is unknown, binding to L-selectin, P-selectin, and a fragment of laminin suggests that CD57 may be involved in cell-matrix interactions. (biolegend.com)
Laminins containing alpha4 and alpha5 chains are expressed in bone marrow, but their interactions with hematopoietic progenitors are unknown. (ox.ac.uk)
In conclusion, we demonstrate laminin isoform-specific adhesive interactions with human bone marrow stem, progenitor, and more differentiated cells. (ox.ac.uk)
Despite its resemblance to the neurosynapse, the participation of soluble small nonpeptidic mediators in the intercellular cross-talk taking place during T cell-DC interactions remains poorly studied. (aai.org)
The CellSphere™ 3D Cell Culture Plate is a series of the cell culture plates with natural 3D environment that is scaffold-free and that maximizes cell-to-cell interactions. (biomaterialsusa.com)
CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)
2. The laminins forms networks that remain in close association with cells through interactions with cell surface receptors. (premiumbeautynews.com)

Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. (wikipedia.org)

The process of metastasis involves the spread of neoplastic cells to locoregional or distant body sites via lymphatic vessels and/or bloodstream. (hindawi.com)

In contrast, in the submucosa, laminin was exclusively found in the basal lamina of blood vessels where many adherent mast cells were seen. (bmj.com)

Interference RNA-mediated knockdown of GPR56 recapitulates the loss of adhesion seen in knock-outs, and reexpression of GPR56 rescues the adhesion defect in knock-out granule cells. (jneurosci.org)
however, knockdown of LAMB1 decreased these effects in gastric cancer cells. (bvsalud.org)
Importantly, enhanced cellular behavior and membrane translocation of PKCd induced by Go¨6976 was retained in siRNA-transfected PC12 cells to knockdown PKCa expression. (mirnamimic.com)
siRNA knockdown of Rac1 and Cdc42 expression inhibited cell spreading and lamellipodia formation in PC12 cells. (mirnamimic.com)

Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. (wikipedia.org)
This gene encodes the gamma chain isoform laminin, gamma 3. (wikipedia.org)
Fluorescence-activated cell-sorting (FACS) analysis showed expression of integrin alpha6 chain on most CD34(+) and CD34(+)CD38(-) cells. (ox.ac.uk)
In PC12 cells, we recently showed that the engagement of integrin a3b1 to a binding sequence within the human laminin a2 chain was sufficient to recruit PKCa and PKCd to the integrin receptor [6]. (mirnamimic.com)
Sdc-1 associates with the 3 chain of LM332 via 31 integrin (8) and with the short arm of the laminin 2 chain via 64 integrin (9). (monossabios.com)

Due to the 34% sequence identity between AChE and neuroligin-1, a neuronal cell adhesion molecule, we postulated that the neuroligin's binding partner, neurexin, may bind to AChE. (tu-darmstadt.de)
Caspr2 is a cell adhesion molecule as well as a receptor. (antibodiesinc.com)
Cells can also regulate the intensity of adhesion and to what molecule they adhere to by way of different mechanisms. (uvigo.es)

These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)
This disease is a defect in fucose metabolism (lack of fucosylation of the carbohydrate selectin ligands) that results in failure to express the ligand for E and P selectin, sialyl Lewis-X (CD15s) expressed on leukocytes and endothelial cells. (medscape.com)

It plays an important role in linking dystrophin to the laminin-binding alpha-dystroglycan. (absoluteantibody.com)
This antibody is capable of immunoprecipitating both alpha-DG and beta-DG from C2C12 cell lysates, suggesting that the binding epitope of this antibody on beta dystroglycan is different from that of alpha dystroglycan. (absoluteantibody.com)

Binds to L-selectin and P-selectin in a calcium-dependent manner, also binds to second globular domain of E8 laminin fragment. (biolegend.com)

The expression of biomarkers can be detected intracellularly or on the cell membrane of melanoma cells or noncancer cells in association with the melanoma. (hindawi.com)
Membrane extract of human lymphoblastoid cell line HSB-2. (biolegend.com)
Trypsin does not act as a reversal of the cell-substrate bond, but rather leads to rounding of the cells and acts on the membrane-cytoskeletal complex. (capricorn-scientific.com)
16. A living cell has a protoplasm which is water based and demarcated by a lipid bilayer membrane. (pharmatutor.org)
3. Cell membrane. (uvigo.es)

Decorin inhibits cell attachment to thrombospondin-1 by binding to a KKTR-dependent cell adhesive site present within the N-terminal domain of thrombospondin-1. (embl.de)
Skin decorin (DCN) is an antiadhesive dermatan sulfate-rich proteoglycan that interacts with thrombospondin-1 (TSP) and inhibits fibroblast adhesion to TSP [Winnemoller et al. (embl.de)
1992]. Molecular mechanisms by which DCN interacts with TSP and inhibits cell adhesion to TSP are unknown. (embl.de)

Recognition of the effective involvement of the myoepithelial cells in mammary gland development and in hampering tumorigenesis has renewed the interest in investigating the biological roles of this second main mammary lineage. (biomedcentral.com)
In this review, we provided an overview of the myoepithelial cells' histogenesis, molecular and biological markers, and physiological commitments. (biomedcentral.com)
Biological activities of laminin are mediated through binding to a subset of integrin family of cell adhesion receptors, a3b1, a6b1, a6b4, and a7b1 [2]. (mirnamimic.com)
The diversity of proteoglycans and their high interaction with growth factors and their receptors provides structural basis for a multitude of biological functions. (premiumbeautynews.com)
Accurate identification of these mechanisms of cell adhesion is essential for further advancement in tissue engineering, such as the production of biological bone substitutes that achieve a better clinical outcome. (bvsalud.org)

Previous studies demonstrated that MSCs could ameliorate the pathology associated with ischemic heart disease, ischemic stroke, and peripheral vascular disease by releasing several critical factors that increase cell survival, provide an appropriate microenvironment for repairing damaged tissue, and induce neovascularization [ 3 - 5 ]. (hindawi.com)
However, liver cirrhosis and intestinal stricture formation are not common in mast cell disease, indicating that besides mast cells additional factors or specific stimulation of mast cells may be necessary to induce severe fibrosis. (bmj.com)
NOTCH3-ADCs internalize into receptor and ligand cells impartial of signaling and induce cell dying in each cell sorts representing an atypical mechanism of ADC cytotoxicity. (kashbiotech.com)

The colocalisation with laminin indicates a mechanism of interaction between smooth muscle cells and mast cells that may be important in the role of mast cells in the process of fibrosis. (bmj.com)
In functional assays, both laminin-8 and laminin-10/11 facilitated stromal-derived factor-1alpha (SDF-1alpha)-stimulated transmigration of CD34(+) cells, by an integrin alpha6 receptor-mediated mechanism. (ox.ac.uk)
Go¨6976 also induced laminin-dependent cell adhesion in NIH/3T3 and CV-1 fibroblasts, suggesting of a mechanism that may be common to multiple cell-types. (mirnamimic.com)

Most commonly, cells are detached - and cell aggregates are dissolved - by enzyme solutions, such as trypsin/EDTA or Accutase TM . (capricorn-scientific.com)

Apical GFAP+ cells are admixed within the ependymal layer and some span between the ventricle and blood vessels, occupying a specialized microenvironment. (nih.gov)

Upon vascular injury, platelets are exposed to the subendothelium, and several agonists, including adenosine diphosphate (ADP) and thrombin, are generated at the injury site, which can stimulate platelet adhesion, activation and aggregation. (spandidos-publications.com)

Here, we examine whether neural stem cells (NSCs) in the adult subventricular zone (SVZ) lie close to blood vessels, using three-dimensional whole mounts, confocal microscopy, and automated computer-based image quantification. (nih.gov)
CD57 is expressed on a subset of peripheral blood lymphocytes, including NK cells and CD8 + T cells, and is also expressed on neural cells and striated muscle. (biolegend.com)

These are structures known as focal adhesions and adhesion junctions. (uvigo.es)

Actin filaments play an necessary function in cell motion, and many posttranslational adjustments regulate actin filament set up. (forgetmenotinitiative.org)
It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. (cancer-genetics.org)

Another reported type of leukocyte adhesion deficiency involves dysfunction in platelet aggregation in addition to a defect in leukocyte adhesion. (medscape.com)

This adhesion was similarly inhibited by excess soluble IgG, confirming the capability of FcγR to mediate cell arrest. (dundee.ac.uk)

This antibody was used in combination with anti-laminin-2 antibody C3_Hu10 to generate a duobody called TBTI (US11254737). (absoluteantibody.com)
The signaling inhibitory antibody quickly induces ligand-independent receptor clustering and internalization via each caveolin and clathrin-mediated pathways. (kashbiotech.com)
The non-inhibitory antibody additionally effectively endocytoses through clathrin with out inducing receptor clustering however with slower lysosomal co-localization kinetics. (kashbiotech.com)
We present that Fc-ARM concentrating on folate receptor-α (FR-α) redirects a clinically used antibody combination to FR-α + most cancers cells, leading to most cancers cell lysis by pure killer cells in vitro . (kashbiotech.com)
Patients with leukocyte adhesion deficiency II manifest the Bombay phenotype (ie, negative for O and H blood group antigens with potential production of anti-H antibody). (medscape.com)

The distribution of gamma 3-containing laminins along ciliated epithelial surfaces suggests that the apical laminins are important in the morphogenesis and structural stability of the ciliated processes of these cells. (wikipedia.org)

Merging extracellular domains: fold prediction for laminin G-like and amino-terminal thrombospondin-like modules based on homology to pentraxins. (embl.de)

Additionally, we showed that c-Jun directly binds to the LAMB1 promoter as a transcription factor and regulates its gene expression via the ERK pathway in gastric cancer cells. (bvsalud.org)

With the increased understanding of molecular mechanisms and basic pathways in the pathogenesis of squamous cell cancer of the head and neck , these pathways may be modified, and rational approaches in cancer therapy at the molecular level may be created. (medscape.com)

It is expressed on activated T cells, monocytes, neuronal cells and smooth muscle cells. (bdbiosciences.com)

Data from a radiolabeled ligand‑binding assay indicated that LGP exhibited apparent competing effects on thromboxane receptor (TP) and P2Y12 receptors. (spandidos-publications.com)
As well as, DLL4 ligand binding to the NOTCH3 receptor mediates transendocytosis of NOTCH3-ADCs into ligand-expressing cells. (kashbiotech.com)

Leukocyte adhesion deficiency (LAD) is a rare primary immunodeficiency. (medscape.com)
Thus the infections in patients with leukocyte adhesion deficiency act similarly as those observed in patients with neutropenia. (medscape.com)
Labial ulceration from which Escherichia coli was cultured in an 8-month-old girl with leukocyte adhesion deficiency type 1 (LAD I). Note the thin bluish scar at the superior aspect of the labia from an earlier cellulitis. (medscape.com)
This 3-year-old girl had leukocyte adhesion deficiency type I (LAD I) with complete absence of CD18 expression. (medscape.com)
This 10-month-old patient with severe leukocyte adhesion deficiency type I (LAD I) developed a cervical adenitis caused by Klebsiella pneumoniae. (medscape.com)
In milder forms of leukocyte adhesion deficiency I (1-30% expression of CD8), patients may survive to adulthood. (medscape.com)
However, IgM and IgG serum levels are within the reference range in patients with leukocyte adhesion deficiency II. (medscape.com)
Leukocyte adhesion deficiency II may be classified as one of the congenital disorders of glycosylation (CDG), a rapidly expanding group of metabolic syndromes with a wide symptomatology and severity. (medscape.com)
Variants of leukocyte adhesion deficiency have also been reported, including fully expressed but nonfunctional CD18 and an E selectin that is expressed but rapidly cleaved from the cell surface (only present in soluble form). (medscape.com)
Thus, patients with this type of leukocyte adhesion deficiency manifest both severe bacterial infections and bleeding disorder. (medscape.com)
This leukocyte adhesion deficiency variant is associated with defective expression of the Rap-1 activator CalDAG-GEFI. (medscape.com)

TissueFab ® - Low endotoxin GelMA-UV Laminin kit enables the precise fabrication of 3D cell models and tissue constructs for research in 3D cell biology, tissue engineering, in vitro tissue models, and regenerative medicine. (sigmaaldrich.com)

There is an emerging understanding of the importance of the vascular system within stem cell niches. (nih.gov)
Pathologic changes seen on autopsy lack major cell and tissue injury but include signs of pleural effusion, pulmonary edema, ascites, and gastrointestinal mucosa bleeding ( 5 , 6 ), all indications of systemic vascular leakage. (cdc.gov)

After the use of search strategies, 18 articles that describe processes of cell adhesion to bone grafts were selected. (bvsalud.org)

Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. (lookformedical.com)
This offers a gentle detachment option and is therefore less harmful for your cells (e.g., no damaging of surface epitopes of the cell). (capricorn-scientific.com)
Cells usually possess a negative surface charge that is unevenly distributed and dependent on the current physiological state of the cell. (capricorn-scientific.com)
The surface will suffer damage and internally the cell will be harmed, e.g., degradation of polyribosomes. (capricorn-scientific.com)
Arrest on HAIgG was inhibited by excess soluble IgG but not by bovine serum albumin (BSA), demonstrating that the adhesion was IgG-specific and presumably mediated by FcγR on the PMN surface. (dundee.ac.uk)
Treatment of PMN with the regulatory neuropeptide substance P also enhanced adhesion to HAIgG-coated fibres and caused increased surface expression of FcγRI, FcγRII and FcγRIII. (dundee.ac.uk)

The extracellular matrix (ECM) acts as an adhesive that holds all the cells of a tissue in place. (biologywise.com)
Due to its low cost, abundance, and retention of natural cell binding motifs, gelatin has become a highly sought material for tissue engineering applications. (sigmaaldrich.com)

This study was conducted to define the potential sequence(s) originating from the G domain of laminin with any of these functional activities. (rupress.org)
CONCLUSIONS The large accumulation of mast cells in the muscle layer of strictured bowel suggests a functional role for these cells in the hypertrophic and fibrotic response of the smooth muscle cells. (bmj.com)

We propose that cells have evolved mechanisms to monitor adhesive status, and that mechanical cues in the extracellular environment are converted into signals linking to one or more cell cycle checkpoints. (manchester.ac.uk)

Avantor® can help equip your life sciences lab with the products, equipment, and supplies you need - whether you work in cell biology, genomics, proteomics, or other fields. (vwr.com)
As our understanding of the molecular biology of HNSCC continues to develop, we can target the specific components of cancer cells that are not found in normal cells. (medscape.com)

Anatomy42

Organisms6

Diseases6

Chemicals and Drugs129

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes47

Disciplines and Occupations1

Technology, Industry, Agriculture3

Information Science4

Differentiation12

Molecules30

Proteins28

Collagen8

Fibronectin4

Basement membrane5

Proliferation10

Neurite5

Migration7

Protein14

Subunit3

Tumor14

Progenitor cells5

Integrins10

Focal adhesion2

Epidermal2

Glycoproteins1

Expression of laminin1

Epithelial cells4

Tissues9

Preceding neurexin1

Interactions8

Heterotrimeric1

Metastasis1

Basal lamina1

Knockdown4

Chain5

Molecule3

Endothelial cells2

Dystroglycan2

Fragment1

Membrane5

Inhibits3

Biological5

Induce3

Mechanism3

Aggregates1

Microenvironment1

Stimulate1

Neural2

Junctions1

Regulate2

Platelet1

Mediate1

Antibody5

Structural1

Thrombospondin1

Binds1

Pathways1

Neuronal1

Ligand2

Leukocyte11

Regenerative Medicine1

Vascular2

Processes1

Surface6

Tissue2

Functional2

Adhesive1

Biology2