Loading...
  • tissue
  • Studies on a variety of cardiac cell therapies have found that the vast majority of the cells don't stick around in the heart for much longer than a few weeks, suggesting that their mode of action is likely not based on the cells themselves producing new muscle tissue directly. (the-scientist.com)
  • For the first time scientists have succeeded in taking skin cells from heart failure patients and reprogramming them to transform into healthy, new heart muscle cells that are capable of integrating with existing heart tissue. (medicalxpress.com)
  • Scientists at Duke University Medical Center have shown the ability to turn scar tissue that forms after a heart attack into heart muscle cells using a new process that eliminates the need for stem cell transplant. (medicalxpress.com)
  • Electrical engineers at ETH Zurich and biologists from the University of Bern have now developed the method further, so that they can easily record the activity of moving cells, such as beating cardiac muscle cells in a tissue culture dish. (nanowerk.com)
  • Even the Wizard of Oz couldn't give the Tin Man a heart but the Johns Hopkins Medical Institution laboratory of John Gearhart has taken another small step on the road toward replenishing damaged cardiac tissue with pre-cursor cardiac cells grown from human embryonic stem cells (ES cells). (innovations-report.com)
  • A heart patient's own skin cells soon could be used to repair damaged cardiac tissue thanks to pioneering stem cell research of the University of Houston's newest biomedical scientist, Robert Schwartz. (phys.org)
  • Johns Hopkins biomedical engineers, working with colleagues in Korea, have produced a laboratory chip with nanoscopic grooves and ridges capable of growing cardiac tissue that more closely resembles natural heart muscle. (phys.org)
  • Discovery of tissue specific stem cells capable of forming cardiac cell types has revolutionized cardiac medicine. (hindawi.com)
  • Not long ago, cardiac tissue regeneration was considered an impossible task. (hindawi.com)
  • These are promising outcomes that indicate that the cells have the ability to modulate cardiac repair programs leading to replacement of the lost tissue. (hindawi.com)
  • Transplanted cells actively home to injury sites and differentiate into new functional tissue to augment organ function. (biocardia.com)
  • The team discovered that the cells grew within the substrate and formed functional layers of tissue that contracted in unison and passed electrical signals. (medgadget.com)
  • the physiological characteristics of the silk-based engineered excitable cardiac tissue are not yet fully studied. (medgadget.com)
  • For example, there is an apparent lack of knowledge of electrophysiological characteristics of the cardiac tissue grown on the silk proteins. (medgadget.com)
  • Thus, we focused on the excitable features of the grown cardiac tissue layers: the main goal of the study was to prove, that besides only survival and growth, the engineered cardiac tissue is able to transmit organized electrical signals for the orchestrated contracting, potentially taking part in the crucial heart's job: pumping blood. (medgadget.com)
  • We hypothesized that functional connexin 43 (Cx43) gap junctions are crucial for MSC and CPCs interaction and integration into cardiac tissue and cardiac stem cell niche formation. (ahajournals.org)
  • Human cardiac tissue engineering can fundamentally impact therapeutic discovery through the development of new species-specific screening systems that replicate the biofidelity of three-dimensional native human myocardium, while also enabling a controlled level of biological complexity, and allowing non-destructive longitudinal monitoring of tissue contractile function. (nih.gov)
  • The defined tissue composition is imperative to understand how the hMSCs may be interacting with the endogenous cardiac cell types to enhance tissue function. (nih.gov)
  • In a rat infarction model, engraftment of nanofabricated scaffolds with CDCs enhanced retention and growth of transplanted cells, and their integration with the host tissue. (rsc.org)
  • These results suggest that nanostructured polymeric materials that closely mimic the extracellular matrix structure on which cardiac cells reside in vivo can be both very effective tools in investigating the mechanisms of cardiac differentiation and the basis for cardiac tissue engineering, thus facilitating stem cell-based therapy in the heart. (rsc.org)
  • The most often transient nature of these arrhythmias may suggest that, once transplanted into cardiac tissue, skeletal muscle cells adopt more cardiac-like electrophysiological properties. (sigmaaldrich.com)
  • researchers
  • Rather than focusing on biochemical cues, these researchers looked at modifying the 3D environment of the cells, with a view to creating an environment more like that found in the heart. (medgadget.com)
  • The researchers plan to test the cells in an animal model of cardiac disease, and also investigate the potential of enhancing electrical conductivity between the cells, to facilitate the cell-cell communication that occurs in the heart. (medgadget.com)
  • To follow what had happened to the injected c-kit cells, the researchers picked out cells with Y chromosomes, finding that they made up 4 percent to 8 percent of the nuclei in the heart. (the-scientist.com)
  • Since the 1970s, a method has been available to researchers that enables measurement of the activity of these channels, but until now this method has been used primarily on cells that do not move. (nanowerk.com)
  • Several years ago, the researchers succeeded in producing sensor tips with an internal channel, which allows the computer-controlled injection of molecules into a cell. (nanowerk.com)
  • The researchers have now published the successful results of this venture in the journal Nano Letters ( 'Force-Controlled Patch Clamp of Beating Cardiac Cells' ). (nanowerk.com)
  • For the first time, researchers have thus succeeded in measuring electric potential changes in the ion channels of beating cardiac cells. (nanowerk.com)
  • The Ohio State researchers ran a number of experiments in animals and cell cultures to establish the relationship after chemo treatment between heat shock factor-1 and the gene that helps the heart, called multidrug-resistance-1 or MDR1. (innovations-report.com)
  • In analyses using heart muscle cells from mice with and without activation of HSF-1, the researchers observed more activation of the MDR1 gene in cells lacking the HSF-1 protein compared to normal mouse heart cells. (innovations-report.com)
  • The researchers discovered that interplay in the heart cells between HSF-1 and another protein, NF-kB, could be traced to production of the protective gene. (innovations-report.com)
  • The researchers also tested breast cancer cells to be sure that brief silencing of the HSF-1 protein before chemotherapy would not induce the multidrug-resistant gene in those cells, which could be a deadly turn of events. (innovations-report.com)
  • In addition to these widely studied stem cell types, researchers have used other extra cardiac stem cell types such as adipose derived stem cells [ 5 ], cortical bone derived stem cells [ 6 ], and cord blood stem cells for cardiac repair. (hindawi.com)
  • Researchers at the Moscow Institute of Physics and Technology have discovered that spider silk can be used as a material for growing myocardial cells outside the body. (medgadget.com)
  • Thanks to several technological breakthroughs and an increasing number of available high-resolution structures of ion channels, such as NaV, researchers are now able to simulate these structures and to modulate the activity of the heart cells by studying their interactions at atomic resolution. (drugdiscoveryonline.com)
  • Our researchers are isolating exosomes from specialized human cardiac-derived stem cells and finding that they have the same beneficial effects as other types of stem cells. (cedars-sinai.edu)
  • Using an engineered virus carrying T-box (TBx18), Cedars-Sinai researchers are reprogramming heart muscle cells (cardiomyoctes) into induced sinoatrial node cells in pigs. (cedars-sinai.edu)
  • pathways
  • Cardiac adaptation encompasses many cell signalling pathways which must be intricately regulated. (bl.uk)
  • Transplanted cells are hypothesized to benefit the heart through direct and indirect pathways, accelerating the body's natural healing process. (biocardia.com)
  • The process by which embryonic stem cells develop into heart cells is a complex process involving the precisely timed activation of several molecular pathways and at least 200 genes. (news-medical.net)
  • Together, the two pathways (named for key proteins) direct stem cells to an intermediate stage from which they further progress into cells of specific organs. (news-medical.net)
  • gene
  • The micropatterning alters the cell cytoskeleton and nuclear shape of cells cultured in the molds, causing changes in gene expression. (medgadget.com)
  • A closer examination on the cellular level suggested that when HSF-1 is blocked in the heart, this condition allows for the activation of a gene that produces a protein to pump the chemo medicine out of heart muscle cells, preventing these cells from dying. (innovations-report.com)
  • In addition, they demonstrated that the MDR1 gene prompted production of a protein on these heart cells' surface that actually pumped doxorubicin away from the cells. (innovations-report.com)
  • When we knock out the protein, not only is the cell death pathway prevented, but it also induces a multidrug-resistant gene, which pumps the drug away from the cells," Ilangovan said. (innovations-report.com)
  • Embryonic gene expression intricately reflects anatomical context, developmental stage, and cell type. (nih.gov)
  • Now, Salk Institute scientists have found a simpler way to go from stem cells to heart cells that involves turning off a single gene. (news-medical.net)
  • Because removing a gene entirely can have unintended effects, the team next wants to test whether they can turn off the YAP gene using small commercially available inhibitor molecules, and still derive functioning cardiac cells from stem cells. (news-medical.net)
  • Aim: We assessed the feasibility and usefulness of reporter gene imaging for PET and iron labeling for MRI to monitor transplanted cells. (ahajournals.org)
  • cardiovascular diseases
  • Conn Hastings received a PhD from the Royal College of Surgeons in Ireland for his work in drug delivery, investigating the potential of injectable hydrogels to deliver cells, drugs and nanoparticles in the treatment of cancer and cardiovascular diseases. (medgadget.com)
  • Scientists are developing novel therapeutics for the treatment of cardiovascular diseases using cardiac-derived stem cells in mice and large-animal models. (cedars-sinai.edu)
  • Survival
  • Using high-throughput screening, they then evaluated how the heart cells responded to treatment with 21 different FDA-approved TKIs, looking at factors like cell survival, signaling and alterations in their ability to beat properly. (technologynetworks.com)
  • utilized adipose derived stem cells to show that curcumin, a naturally occurring food chemical, can promote angiogenic and survival ability of the cells augmenting their potential for the repair of ischemia reperfusion injury to the heart. (hindawi.com)
  • CM significantly increased cardiac cell survival from DOX toxicity as evaluated by MTT assay. (hindawi.com)
  • membrane
  • A new approach to analyzing cell membrane proteins in situ could revolutionize the way in which we study diseases, such as cancer, metabolic and heart diseases. (technologynetworks.com)
  • The existing method involves positioning a glass pipette against the outer membrane of a cell. (nanowerk.com)
  • Ideally, this tiny patch of cell membrane has exactly one ion channel. (nanowerk.com)
  • The method is referred to as the patch-clamp technique because the pipette is used to clamp a patch of the cell membrane. (nanowerk.com)
  • These simulations, published today in PNAS (Proceedings of the National Academy of Sciences), may lead the way to better development of new antiarrhythmic drugs targeting voltage-gated sodium (NaV) channels, specialized protein molecules in the cardiac cell membrane. (drugdiscoveryonline.com)
  • impulses
  • Nanowerk News ) Electrical impulses play an important role in cells of the human body. (nanowerk.com)
  • The impulses are generated when special channel proteins open in the outer envelope of the cells, allowing charged molecules (ions) to enter or exit the cell. (nanowerk.com)
  • Also, to carry electrical impulses sent out by pacemaker cells to the muscles signaling the heart to pump. (prezi.com)
  • Cedars-Sinai research shows that these new cells generate electrical impulses spontaneously and are indistinguishable from sinoatrial node or native pacemaker cells. (cedars-sinai.edu)
  • behavior
  • The mechanical properties of substrates play an important role in the cell behavior because the mechanical cues that cells sense in the actual (heart) environment is unique," said Abadi. (medgadget.com)
  • patients
  • In the current study, the scientists demonstrated that human-induced pluripotent stem cells can be used to model how TKIs might affect the hearts of patients receiving chemotherapy. (technologynetworks.com)
  • C-kit cells have also been deployed in a clinical trial on heart attack patients led by Bolli's group and Piero Anversa's team, then at Harvard. (the-scientist.com)
  • A drug that blocks ion channels may cause severe cardiac dysrhythmia in patients, which should be avoided at all costs. (nanowerk.com)
  • Subsequent research has shown, however, that certain specific cells can be taken from the body fat or bone marrow of healthy young individuals and may be used therapeutically in older patients without adverse immunological reaction. (parentsguidecordblood.org)
  • Numerous human cardiac stem cell studies have been published, including relatively small number of patients. (clinicaltrials.gov)
  • conduction
  • When the drug molecules enter these channels, they bind tightly to the receptor site within the protein preventing the sodium ions from entering the cell and blocking the channel conduction. (drugdiscoveryonline.com)
  • Sodium (Na + ) currents are responsible for excitation and conduction in most cardiac cells, but their study has been hampered by the lack of a satisfactory method for voltage clamp. (springer.com)
  • Embryonic Stem
  • At the meeting: Session 238 Embryonic Stem Cells, Poster Presentation 1208, Halls D/E. Author presents: Monday, Dec. 6, Noon-1:30 PM. (innovations-report.com)
  • In 2015, Jones' lab, which studies proteins that manage cell growth and development, discovered that two different cellular processes cooperate to enable embryonic stem cells (ESCs) to develop into specific cell types like pancreas, liver and heart. (news-medical.net)
  • heart muscle
  • Programming induced pluripotent stem cells into heart muscle cells requires biochemical and biomechanical cues. (medgadget.com)
  • Stem cells play a role in heart muscle rejuvenation by attracting cells from the body that develop into heart muscle cells. (phys.org)
  • Our first-in-the-world stem cell research at the the Stem Cell Center of the Texas Heart Institute, and subsequent clinical trials in humans, have shown that a patient's own stem cells, harvested from their bone marrow, can help generate new heart muscle tissues and blood vessels in hearts damaged by heart attacks or severe heart failure. (parentsguidecordblood.org)
  • This research suggests that exosomes convey messages that reduce cell death, promote growth of new heart muscle cells and encourage the development of healthy blood vessels. (cedars-sinai.edu)
  • scientists
  • With the stem-cell data, the scientists were able to create a "cardiac safety index," which ranks the TKIs on their likelihood of inflicting heart damage. (technologynetworks.com)
  • In some cases, subjects have ended up with better cardiac function, but exactly how has been a subject of disagreement among scientists. (the-scientist.com)
  • In this study, scientists identified a protein called heat shock factor-1 (HSF-1) as a likely source of chemotherapy-related heart damage in mice and cell cultures. (innovations-report.com)
  • tissues
  • Cardiac system is responsible for pumping oxygen rich blood to the organs, tissues and cells in the body and removing carbon dioxide and waste. (creative-bioarray.com)
  • To address this limitation, we utilize live cell sorting for the cardiac surface marker SIRPα and the fibroblast marker CD90 to create tissues containing a 3:1 ratio of these cell types, respectively, that are then mixed together and added to a collagen-based matrix solution. (nih.gov)
  • molecules
  • Cytokines are cell signaling molecules that aid cell to cell communication in immune responses and stimulate the movement of healthy cells towards sites of inflammation, infection and trauma. (biocardia.com)
  • doxorubicin
  • Here we investigated the protective effect of pummelo ( Citrus maxima , CM) fruit juice in rat cardiac H9c2 cells against doxorubicin (DOX-) induced cytotoxicity. (hindawi.com)
  • In addition to abrogation of oxidative stress by chemically active antioxidants, the removal of anthracycline toxic metabolites by phase II metabolizing enzyme glutathione transferases (previously glutathione-S transferases, GST) has been implicated in the protection of doxorubicin-induced cardiac cell death [ 8 , 9 ]. (hindawi.com)
  • mitochondria
  • The redox recycling of semiquinone and its parent quinone is known to generate reactive oxygen species (ROS) leading to mitochondria dysfunction, myocyte senescence, and apoptosis, and ultimately causing cardiac remodeling and contractility impairment [ 2 , 3 ]. (hindawi.com)
  • paracrine
  • So the mechanism is clearly a paracrine action, where the cells release 'something' which makes the heart better. (the-scientist.com)
  • That the transplanted cells have a paracrine effect has been shown multiple times," Nadal-Ginard wrote in an email to The Scientist . (the-scientist.com)
  • successfully
  • Cardiac cells successfully adhered and grew on the spidroin fiber meshes obtained by electrospinning, forming contractile and excitable cell network supported by the spidroin fibers. (medgadget.com)
  • biology
  • The patch-clamp technique is not only a central method for basic research in cell biology, it is also used routinely in the development of new drugs. (nanowerk.com)
  • To give you confidence in the health of your cells every step of the way, we've highlighted the technologies and products within cell biology that are critical to maintaining optimal cell health. (thermofisher.com)