TumorsDuctalPancreasQuickly than acinar adenocarcinomaAcinic Cell CarcTypes of pancreaticSquamous cell carcRenalEpithelialNeoplasmsCancersTransitionalUrothelial carcinomaProstatic carcinomaHepatocellular carcinomaAdenocarcinomasSarcomatoidSalivary glandBiopsySubtypesCysticLungFlat cells that cover the prostateNeuroendocrine tumorMolecular FeaturesGastrointestinalClinicopathologicGenesAlterationsTumor cellsProliferationCarcinoidSpindleBladderTissueRarePrimaryTypicallyDuctsKidneyPatternsTherapeutic
Tumors20
- Islet cell tumors may occur in children with multiple endocrine neoplasia type 1 (MEN1) syndrome. (cancer.gov)
- The most common types of islet cell tumors are insulinomas and gastrinomas . (cancer.gov)
- Other types of islet cell tumors are ACTHoma and VIPoma . (cancer.gov)
- The results confirm that acinar cell carcinoma of the pancreas has a completely different tumor biology and, hence, a different development history than tumors of the pancreatic duct," Schmezer said. (dkfz.de)
- In general, pancreatic tumors are divided into two broad categories based on the type of cell that the cancer originated in. (moffitt.org)
- These tumors can pop up in neuroendocrine cells anywhere in the body. (webmd.com)
- Rarely, tumors grow inside neuroendocrine cells of the prostate. (webmd.com)
- Cancer Research UK: "Types of Prostate Cancer," "Small cell prostate cancer," "What are neuroendocrine tumors? (webmd.com)
- Starting from cells of the neuroendocrine system, specialized nerve and gland cells, these tumors are rare and slow-growing. (issels.com)
- Epithelial tumors of nasal cavity, sinuses, nasopharynx: A) Squamous cell carcinoma with variants of nasal cavity, sinuses, and nasopharynx and trachea (excluding laryngeal, nasopharyngeal cancer [NPC], and squamous cell carcinoma of the head and neck [SCCHN]) B) Adenocarcinoma and variants of nasal cavity, sinuses, and nasopharynx (closed to accrual 07/27/2018) 2. (sncrf.org)
- Rare pancreatic tumors including acinar cell carcinoma, mucinous cystadenocarcinoma or serous cystadenocarcinoma. (sncrf.org)
- Non-epithelial tumors of the ovary: A) Germ cell tumor of ovary B) Mullerian mixed tumor and adenosarcoma (closed to accrual 03/30/2018) 14. (sncrf.org)
- Cell tumor of the testes and extragonadal germ tumors: A) Seminoma and testicular sex cord cancer B) Non seminomatous tumor C) Teratoma with malignant transformation (closed to accrual) 17. (sncrf.org)
- Epithelial tumors of penis - squamous adenocarcinoma cell carcinoma with variants of penis (closed to accrual) 18. (sncrf.org)
- Malignant giant cell tumors 30. (sncrf.org)
- Increasingly, renal cell cancers are diagnosed at an earlier stage, and nephron-sparing surgery and thermal ablation are gaining acceptance as a treatment of choice for smaller tumors. (medscape.com)
- In colorectal carcinoma 90 % of all tumors have a mutation in a gene coding for regulatory components of the canonical Wnt signaling pathway such as CTNNB1 (β-catenin) or adenomatous polyposis coli (APC). (biomedcentral.com)
- In hepatocellular carcinoma 3 to 44 % of tumors contain mutations of CTNNB1 and 5 to 25 % contain mutations in AXIN1 resulting in activation of Wnt signaling [ 4 ]. (biomedcentral.com)
- A small proportion of these tumors show large ducts lined by neoplastic cells, the so-called large-duct variant of adenocarcinoma. (coek.info)
- Most pancreatic cancers are exocrine tumors that develop from ductal and acinar cells. (msdmanuals.com)
Ductal7
- The two types of pancreatic carcinoma are acinar cell carcinoma and ductal adenocarcinoma . (cancer.gov)
- In their analysis of acinar cell carcinomas, the DKFZ researchers found no recurrent cancer-promoting point mutations in tumor-relevant genes, which are characteristic for pancreatic ductal carcinomas. (dkfz.de)
- In hyperplastic prostates and in benign prostatic tissue adjacent to the prostatic carcinoma, PAP activity is limited to the acinar or ductal columnar epithelial cells and adjacent luminal content. (biogenex.com)
- Activation of Wnt signaling was observed during acinar-to-ductal metaplasia after chronic as well as acute pancreatitis. (biomedcentral.com)
- These data demonstrate that the Wnt signaling pathway is activated during acinar-to-ductal metaplasia after injury to the pancreas. (biomedcentral.com)
- Thus, the purpose of this study was to evaluate the activation of the Wnt signaling pathway in precancerous lesions such as tubular complexes after acinar-to-ductal metaplasia (ADM) and during the tumor stroma interaction of fully established PDA. (biomedcentral.com)
- In spite of their aggressive biologic behavior, some ductal adenocarcinomas show bland nuclear features, making the distinction of benign lesion from an invasive carcinoma difficult, particularly on small biopsy specimens (Fig. 1). (coek.info)
Pancreas15
- Acinar cell carcinoma of the pancreas, also acinar cell carcinoma, is a rare malignant exocrine tumour of the pancreas. (wikipedia.org)
- Representative examples include the acinar cell carcinoma of the pancreas and the acinar adenocarcinoma of the prostate gland. (nih.gov)
- Metastatic Acinar Cell Carcinoma of the Pancreas: A Retrospective Cohort Study on Systemic Chemotherapy and Review of the Literature. (nih.gov)
- Pancreatic cancer is a disease in which malignant (cancer) cells form in the tissues of the pancreas. (cancer.gov)
- Endocrine pancreas cells cluster together in many small groups (islets) throughout the pancreas. (cancer.gov)
- Endocrine pancreas cells are also called islet cells or islets of Langerhans. (cancer.gov)
- Exocrine pancreas cells make enzymes that are released into the small intestine to help the body digest food. (cancer.gov)
- Most of the pancreas is made of ducts and small sacs at the end of the ducts that are lined with exocrine cells . (cancer.gov)
- Metastasis of cancerous cells can affect organs surrounding the pancreas, including the stomach and the colon. (medscape.com)
- In addition, there are a number of much less common cancer types, including acinar cell carcinoma, that develop from specific exocrine cells of the pancreas. (dkfz.de)
- For very rare cancers such as acinar cell carcinoma of the pancreas, it is difficult to test the effectiveness of novel drugs in classic clinical trials. (dkfz.de)
- Whole exome sequencing reveals recurrent mutations in BRCA2 and FAT genes in acinar cell carcinomas of the pancreas. (antikoerper-online.de)
- Those are cells that make hormones to help the function of the organ they occupy, such as the lungs, stomach , and pancreas . (webmd.com)
- Squamous cell carcinoma with variants of GI tract (stomach small intestine, colon, rectum, pancreas) (closed to accrual 10/17/2018) 7. (sncrf.org)
- Pancreatic neuroendocrine tumor (PNET) (formerly named: Endocrine carcinoma of pancreas and digestive tract. (sncrf.org)
Quickly than acinar adenocarcinoma2
- Spreads more quickly than acinar adenocarcinoma. (issels.com)
- It tends to grow and spread more quickly than acinar adenocarcinoma. (cancerresearchuk.org)
Acinic Cell Carc1
- Diagnosis of acinic cell carcinoma of the salivary gland on cytology specimens: Role of NOR‐1 (NR4A3) immunohistochemistry Meiklejohn K, Hrones M, Wang M, Prasad M, Cai G , Adeniran A, Gilani S. Diagnosis of acinic cell carcinoma of the salivary gland on cytology specimens: Role of NOR‐1 (NR4A3) immunohistochemistry. (yale.edu)
Types of pancreatic1
- Cancer can develop in the cells of two types of pancreatic glands: exocrine glands and endocrine glands. (moffitt.org)
Squamous cell carc1
Renal13
- Transitional cell carcinoma other than that of the renal, pelvis, ureter, or bladder (closed to accrual) 16. (sncrf.org)
- Patients with SCA, specially with this pseudo solid-appearance, such as the present case, may have imaging findings that closely resemble those of patients with pancreatic neuroendocrine neoplasms (pNENs), metastatic renal cell carcinoma, solid pseudopapillary tumor or acinar cell carcinomas (1,4). (spg.pt)
- Renal cell carcinoma (RCC) may remain clinically occult for most of its course. (medscape.com)
- Twenty-five to thirty percent of patients are asymptomatic, and their renal cell carcinomas are found on incidental radiologic study. (medscape.com)
- Renal cell carcinoma is a unique and challenging tumor because of the frequent occurrence of paraneoplastic syndromes, including hypercalcemia, erythrocytosis, and nonmetastatic hepatic dysfunction (ie, Stauffer syndrome). (medscape.com)
- Approximately 30% of patients with renal carcinoma (RCC) present with metastatic disease. (medscape.com)
- Although patients with Robson stage IIIB renal carcinoma have greatly decreased survival rates, the prognosis for patients with stage Robson IIIA renal carcinoma is not markedly different from that for patients with Robson stage I or II renal carcinoma. (medscape.com)
- Renal cell carcinoma (see the image below) is the most common type of kidney cancer in adults. (medscape.com)
- See Renal Cell Carcinoma: Recognition and Follow-up , a Critical Images slideshow, to help evaluate renal masses and determine when and what type of follow-up is necessary. (medscape.com)
- Surgical resection remains the only known effective treatment for localized renal cell carcinoma, and it is also used for palliation in metastatic disease. (medscape.com)
- Renal cell carcinoma (RCC) accounts for approximately 3% of adult malignancies and 90-95% of neoplasms arising from the kidney. (medscape.com)
- Go to Clear Cell Renal Cell Carcinoma and Sarcomatoid and Rhabdoid Renal Cell Carcinoma for complete information on these topics. (medscape.com)
- The tissue of origin for renal cell carcinoma (RCC) is the proximal renal tubular epithelium. (medscape.com)
Epithelial5
- A malignant glandular epithelial neoplasm consisting of secretory cells forming acinar patterns. (nih.gov)
- By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
- Synovial sarcomas encompass both biphasic (epithelial and spindle cell components) and monophasic (purely spindle cell) variants. (medscape.com)
- Immunohistochemical analysis showed PAP has been found localized within the large secretory vacuoles of the supra nuclear portion of the prostatic columnar epithelial cell. (biogenex.com)
- The histological examination from the FNA sample revealed a scarce specimen for evaluation, with columnar epithelial cells with mild atypia, positive for CK7 and 19, negative for p53, chromogranin A and synaptophysin. (spg.pt)
Neoplasms2
- Pancreatic Neoplasms With Acinar Differentiation: A Review of Pathologic and Molecular Features. (nih.gov)
- SFTs of the pleura are localized mesenchymal neoplasms composed of fibroblastlike cells believed to arise from the subpleural connective tissue. (medscape.com)
Cancers5
- The majority of pancreatic cancers arise in the exocrine cells. (moffitt.org)
- These cancers start in the gland cells of the prostate. (webmd.com)
- Small-cell carcinomas make up about 1% of prostate cancers. (webmd.com)
- Acinar adenocarcinoma begins in the gland cells in the prostate, and comprise more than 90 percent of prostate cancers, including atrophic, foamy, colloid and signet ring carcinoma. (issels.com)
- These cancers develop from flat cells that cover the prostate. (cancerresearchuk.org)
Transitional2
- Transitional cell (or urothelial) cancer. (webmd.com)
- Transitional cell carcinoma of the prostate starts in the cells that line the tube carrying urine to the outside of the body (the urethra). (cancerresearchuk.org)
Urothelial carcinoma2
- Correlation between PD-L1 expression of the tumour cells and lymphocytes infiltration in the invasive front of urothelial carcinoma Chen X, Chen H, Lin R, Li Y, Guo Y, Chen Q, Zhang Y, Cai G , Hu M, Chen G. Correlation between PD-L1 expression of the tumour cells and lymphocytes infiltration in the invasive front of urothelial carcinoma. (yale.edu)
- This is sometimes called urothelial carcinoma of the prostate. (cancerresearchuk.org)
Prostatic carcinoma3
- Small cell carcinoma (SCC) of the prostate represents a rare form of prostatic carcinoma. (karger.com)
- Abrahamsson PA: Neuroendocrine differentiation in prostatic carcinoma. (karger.com)
- PAP measurement is clinically significant, the rise in serum levels of Prostate acid phosphatase (PAP) is co-related with prostatic carcinoma. (biogenex.com)
Hepatocellular carcinoma1
- Hepatic cholesterol accumulation and hypercholesterolemia are implicated in hepatocellular carcinoma (HCC). (nature.com)
Adenocarcinomas1
- Adenocarcinomas develop in the gland cells that line the prostate gland and the tubes of the prostate gland. (cancerresearchuk.org)
Sarcomatoid2
Salivary gland1
- Mucoepidermoid carcinoma is the most common salivary gland malignancy in children. (medscape.com)
Biopsy2
- Light microscopy of an acinar cell carcinoma biopsy typically shows granular appearance. (wikipedia.org)
- The availability of tools to interrogate the transcriptome and proteome, such as expression profiling, have identified a substantial library of products that could aid in distinguishing a well-differentiated pancreatic carcinoma from a benign pancreatic lesion.2 Many of these proteins can be detected immunohistochemically and are thus available to the practicing pathologist (Table 2).3 Some of these markers have been validated on biopsy specimens as well. (coek.info)
Subtypes4
- Insights into the oncological characteristics and tumor microenvironment (TME) of different histologic subtypes of LUAD at the single-cell level can help identify potential therapeutic vulnerabilities and combinational approaches to improve the survival of LUAD patients. (nih.gov)
- Through comparative profiling of cell communities defined by scRNA-seq data, we characterized the TME of LUAD samples of distinct histologic subtypes, with relevant results further confirmed in multiple bulk transcriptomic, proteomic datasets and an independent immunohistochemical validation cohort. (nih.gov)
- Besides, the tumor metabolic preferences vary across histologic subtypes and may correspondingly impinge on the metabolism and function of immune cells. (nih.gov)
- All subtypes of acinar adenocarcinoma are treated in the same fashion. (issels.com)
Lung5
- [ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
- GATA3 expression in primary lung carcinomas: correlation with histopathologic features and TTF-1, napsin A, and p40 expression Wang M, Chen P, Cai G . GATA3 expression in primary lung carcinomas: correlation with histopathologic features and TTF-1, napsin A, and p40 expression. (yale.edu)
- Non-neoplastic smoke-related lung disease: chronic obstructive pulmonary disease, small airways disease/respiratory bronchiolitis, Langerhans cell histiocytosis of the lung. (unibo.it)
- Bronchoalveolar carcinoma lung. (sncrf.org)
- Neuroendocrine carcinoma including carcinoid of the lung (closed to accrual 12/19/2017) 24. (sncrf.org)
Flat cells that cover the prostate1
- It starts in flat cells that cover the prostate. (webmd.com)
Neuroendocrine tumor1
- A type of neuroendocrine tumor comprised of small, round cells. (issels.com)
Molecular Features1
Gastrointestinal2
- Undifferentiated carcinoma of gastrointestinal (GI) tract 5. (sncrf.org)
- It is well established that Wnt signaling is involved in the cancerogenesis of multiple gastrointestinal carcinomas [ 4 ]. (biomedcentral.com)
Clinicopathologic1
- Ali SZ, Reuter VE, Zakowski MF: Small cell neuroendocrine carcinoma of the urinary bladder: a clinicopathologic study with emphasis on cytologic features. (karger.com)
Genes2
- In approximately 70 percent of the acinar cell carcinomas under investigation, the researchers discovered defective DNA repair genes that can result in the failure of cells to repair defects in the genetic material. (dkfz.de)
- In addition, the investigators found frequent mutations in genes that control the cell cycle as well as genetic defects that are caused by tobacco consumption. (dkfz.de)
Alterations2
- The good news is that for many of the frequent alterations that we found in acinar cell carcinoma, targeted agents are already available and some of them are even already approved for therapy. (dkfz.de)
- About 24 % of acinar cell carcinomas (ACC) have molecular alterations in the canonical Wnt signaling pathway. (biomedcentral.com)
Tumor cells5
- Remarkably, tumor cells from solid LUADs upregulate energy and substance metabolic activities, particularly the folate-mediated one-carbon metabolism and the key gene MTHFD2, which could serve as a potential therapeutic target. (nih.gov)
- On microscopic examination, the smears were cellular and showed many loose cohesive clusters and dispersed tumor cells in a background of abundant reactive lymphoid cells and hemorrhage [Figure 1a and b ]. (cytojournal.com)
- The tumor cells were arranged in focal acinar or follicular pattern with a round-to-oval nucleus, moderate anisonucleosis, fine nuclear chromatin, and moderate-to-abundant fragile cytoplasm with the focal presence of fine granules. (cytojournal.com)
- Few bizarre and binucleated tumor cells were also noted [Figure 1c and d ]. (cytojournal.com)
- Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. (sncrf.org)
Proliferation2
- These agents inhibit cell growth and proliferation. (medscape.com)
- While the tumor is often considered to arise from neuroendocrine proliferation or possibly dedifferentiation of an acinar carcinoma, the precise etiology remains uncertain. (karger.com)
Carcinoid2
- Atypical Carcinoid Tumor Versus Large-Cell Neuroendocrine Carcinoma Yoon E, Cai G . Atypical Carcinoid Tumor Versus Large-Cell Neuroendocrine Carcinoma. (yale.edu)
- Small-Cell Carcinoma Versus Atypical Carcinoid Tumor Yoon E, Zhang X, Cai G . Small-Cell Carcinoma Versus Atypical Carcinoid Tumor. (yale.edu)
Spindle2
- DSRCT is composed of small cells with round hyperchromatic nuclei and a dense fibrous or spindle cell stroma. (medscape.com)
- Spindle cell carcinoma of kidney, pelvis, ureter 20. (sncrf.org)
Bladder1
- Abbas F, Civantos F, Benedetto P, Soloway MS: Small cell carcinoma of the bladder and prostate. (karger.com)
Tissue2
Rare3
- Pancreatic carcinoma is very rare in children. (cancer.gov)
- Small cell prostate cancer is a rare type of prostate cancer. (cancerresearchuk.org)
- Acinar cell carcinoma is a rare cause of pancreatic cancer. (msdmanuals.com)
Primary1
- Bolton DM, Chiu ST, Clarke S, Angus D: Primary small cell carcinoma of the prostate: unusual modes of presentation. (karger.com)
Typically1
- Histomorphologically, the tumour resembles the cells of the pancreatic acini and, typically, have moderate granular cytoplasm that stain with both PAS and PASD. (wikipedia.org)
Ducts2
- This kind starts in the cells that line the ducts (or tubes) of the prostate gland. (webmd.com)
- Originates in the cells lining the ducts (tubes) of the prostate gland. (issels.com)
Kidney1
- Internalization was studied in AR4-2J cells at 37°C. Radiopeptide stability was tested in murine plasma, urine, and kidney homogenates. (snmjournals.org)
Patterns1
- Very frequently, the labeling of the genome with small chemical labels differs from methylation patterns in healthy cells. (dkfz.de)
Therapeutic1
- Rubenstein JH, Katin MJ, Mangano MM, Dauphin J, Salenius SA, Dosoretz DE, Blitzer PH: Small cell anaplastic carcinoma of the prostate: seven new cases, review of the literature and discussion of a therapeutic strategy. (karger.com)