Cell cancer cells cell nucleus. Medical search. Frequent questions

While some techniques only perform the task of cell nuclei segmentation and quantification, techniques that are capable of further detecting and classifying abnormal tumors (cell nuclei) that cause various types of cancer have also been proposed. (hindawi.com)
SAFER CANCER GENE THERAPY A twist on a well-studied gene therapy may more safely melt tumors. (the-scientist.com)
In this study, we identified a long noncoding RNA (lncRNA), NXTAR (LOC105373241), that is located convergent with the AR gene and is repressed in human prostate tumors and cell lines. (genengnews.com)
This means that in all the prostate cancer samples that we study, we rarely find NXTAR, because it is suppressed by the heavy presence of the androgen receptor in these types of tumors. (genengnews.com)
Breast cancers usually are epithelial tumors of ductal or lobular origin. (medscape.com)
To determine whether the gene amplification in cells is morphologically and/or genetically related to the primary tumor requires quantitative evaluation of a large number of cell nuclei from continuous meaningful structures such as milk-ducts, tumors, etc., located relatively far from the primary tumor. (nih.gov)
Wieschaus discovered that cancer can co-opt this pathway, essentially corrupting its ability to grow as rapidly as embryos must, to grow tumors. (princeton.edu)
While the origin of these tumors is still not definitively known, the two theories with the most support suggest that these tumors arise from a primitive cell derived either from an embryologic tissue called the neural crest, or from resident cells in the body (called mesenchymal stem cells) that have a capability to become one of a variety of tissue types. (sarcomahelp.org)
Subsequently, these two tumors have been grouped into a class of cancers entitled Ewing's Sarcoma Family of Tumor (ESFT), all of which demonstrate this translocation. (sarcomahelp.org)
Tumors in the Ewing's family of sarcomas are made of primitive cells, which are cells that haven't yet decided what type of cell they are. (sarcomahelp.org)
Although Hürthle cell carcinoma was previously considered a variant of follicular cell neoplasms, which are generally less aggressive, the 2017 World Health Organization (WHO) classification of endocrine tumors reclassified it as a distinct entity. (medscape.com)
[ 5 ] The 2022 WHO classification of endocrine tumors has replaced the term Hürthle cell carcinoma with oncocytic carcinoma. (medscape.com)
Overall, only about 33% of Hürthle cell tumors demonstrate signs of that invasive growth that indicates malignancy and the possibility of metastasis. (medscape.com)
On balance, Hürthle cell tumors may be considered to be more likely to metastasize than follicular tumors. (medscape.com)
Permissive histologic interpretation may result in the designation of some non-neoplastic Hürthle cell lesions as malignant tumors. (medscape.com)
Our overall aim is to understand how TAM immunosuppressive and pro-metastatic functions are regulated and if these TAMs can be used as mechanistic, predictive and prognostic tools for different solid tumors, including breast cancer, adult and pediatric sarcoma, and other solid tumors. (lu.se)
Breast Cancer Breast cancers are most often epithelial tumors involving the ducts or lobules. (msdmanuals.com)

Merajver's lab at the Rogel Cancer Center worked with a Michigan Engineering team led by Allen Liu, Ph.D., and postdoctoral researcher Luciana Rosselli-Murai, Ph.D. They focused on a protein called clathrin, which impacts how metabolites, hormones and other proteins enter into a cell. (eurekalert.org)
Signals must get from outside the cell into its nucleus to produce proteins. (eurekalert.org)
The research, supported by the National Institutes of Health, centers on a cellular chaperone protein known as GRP78, which helps regulate the folding of other proteins inside cells. (news-medical.net)
GRP78 could also bind to other proteins in the nucleus critical for cancer, opening up a new line of research in cancer biology. (news-medical.net)
Lee said it's possible-;even likely-;that other proteins that typically reside in one part of the cell could, under stress or other triggers, migrate to another part of the cell and alter cell behavior in multiple ways. (news-medical.net)
It can image DNA, chromatin and proteins in cells in their native states, without the need for labels. (news-medical.net)
For decades, textbooks have stated that macromolecules within living cells, such as DNA, RNA and proteins, do not have visible fluorescence on their own. (news-medical.net)
To fit into the tiny cell nucleus, it is condensed around proteins called histones. (unige.ch)
The proteins that play a role in stimulating cell division can be classified into four groups- growth factors , growth factor receptors , signal transducers, and nuclear regulatory proteins ( transcription factors ). (britannica.com)
Cells use special proteins and checkpoint signaling systems to ensure that the cell cycle progresses properly. (britannica.com)
However, the cell cycle and its checkpoint systems can be sabotaged by defective proteins or genes that cause malignant transformation of the cell, which can lead to cancer . (britannica.com)
DNA-repair enzyme inhibitors attack the cancer cell proteins (enzymes) that normally repair damage to DNA. (lls.org)
Histone deacetylase inhibitors attack cancer cells by targeting the proteins that support DNA in the cell nucleus. (lls.org)
Monoclonal antibodies are laboratory-produced proteins that target specific antigens on the cancer cell's surface to interfere with the cell's function and destroy it. (lls.org)
They act like switches in the cell - turning on other proteins. (lls.org)
Actin and actin-binding proteins in the oocyte nucleus play important roles in this reprogramming. (selectbiosciences.com)
Lu's study showed that p53 is inhibited by two proteins in melanoma cells, iASPP and MDM2. (medindia.net)

But when cells are under stress, the chaperone protein migrates to the cell's nucleus, where it alters gene activities and changes the behavior of the cell, allowing the cancer cells to become more mobile and invasive. (news-medical.net)
Many of the secrets of cancer and other diseases lie in the cell's nucleus. (news-medical.net)
While the classical membrane-bound functions of HER family RTKs have been extensively studied, accumulating data suggest that these receptors can be found in the cell's nucleus where they can function as co-transcriptional activators [4] , [5] . (plos.org)

DESCRIPTION (provided by applicant): NIH sponsored cancer researchers have been obtaining promising results using molecules radiolabeled with lead-212 in treatment for metastatic melanoma and disseminated colon and pancreatic cancers. (sbir.gov)
While the present study analyzed lung cancer cells, GRP78 plays a similar role in various types of cancers, including pancreatic, breast and colon cancer. (news-medical.net)
Plac8 Links Oncogenic Mutations to Regulation of Autophagy and Is Critical to Pancreatic Cancer Progression. (rochester.edu)
10 TRPV1 agonist, capsaicin, is capable of inducing apoptosis 11 , 12 and inhibiting cancer cell growth by cell cycle arrest in many different types of cancer, for example, osteosarcoma, colon, and pancreatic cancer cells, while normal cells remained unharmed. (dovepress.com)

DESCRIPTION (provided by applicant): This proposal outlines a body of research to evaluate the cytotoxicity and therapeutic efficacy of radiolabeled alpha-melanocyte stimulating hormone (a-MSH) peptide analogs that target a-particle emitting radioisotopes to the nuclei of melanoma cells. (sbir.gov)
Recent reports have indicated that terpinen-4-ol exerts its antitumor effects by triggering caspase-dependent apoptosis in human melanoma cells or by inducing necrotic cell death and cell-cycle arrest in mouse mesothelioma and melanoma cell lines without affecting normal cells [ 14 , 15 ]. (hindawi.com)
To do so, they treated melanoma cells with a panel of small molecules and identified JNJ-7706621 (JNJ) as the best inhibitor of cyclinB1/cdk1. (medindia.net)
When JNJ and the Nutlin-3 were combined, the full function of p53 was restored in metastatic melanoma cells. (medindia.net)

Although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. (nature.com)
Is p53-dependent ferroptosis sufficient for tumor suppression in the absence of cell cycle arrest, senescence, and apoptosis? (nature.com)
To date, various mechanisms have been suggested to explain the powerful tumor-suppressive effect of p53, including the induction of cell cycle arrest, senescence, and apoptosis. (nature.com)
Here, we describe a novel approach to functionalize human and murine leukocytes with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on their surface, along with E-selectin (ES), to capture and induce cancer cell apoptosis both in vitro in human blood and in vivo in mouse circulation. (aiche.org)
We have shown that leukocytes functionalized with ES/TRAIL can capture and induce cancer cell apoptosis in vitro in human blood and in vivo in mouse experiments. (aiche.org)
Since epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors, including gefitinib (GEF) have been reported to induce the apoptosis of several cancer cell lines, in the present study, we examined whether the cytotoxic effects of GEF are further enhanced under amino acid starvation (AAS) culture conditions. (spandidos-publications.com)
Potential synergistic effects of various combinations including these compounds were tested by measuring cancer cell proliferation and apoptosis. (frontiersin.org)
Diminution of p53 by RNA interference induced necrosis instead of apoptosis in A549 cells following terpinen-4-ol treatment, indicating that terpinen-4-ol-elicited apoptosis is p53-dependent. (hindawi.com)
Collectively, these data provide insight into the molecular mechanisms underlying terpinen-4-ol-induced apoptosis in NSCLC cells, rendering this compound a potential anticancer drug for NSCLC. (hindawi.com)
Our results indicated that terpinen-4-ol induced apoptosis through a mitochondria-mediated pathway in NSCLC cells and that the apoptosis elicited by terpinen-4-ol was p53 dependent. (hindawi.com)
Resveratrol could play a toxic role through inducing apoptosis of the cancer cell in a time- and concentration-dependent manner. (mdpi.com)
If DNA damage or abnormalities in spindle formation are detected at these checkpoints, the cell is forced to undergo programmed cell death, or apoptosis . (britannica.com)
For example, mutations in a protein called p53 , which normally detects abnormalities in DNA at the G1 checkpoint, can enable cancer-causing mutations to bypass this checkpoint and allow the cell to escape apoptosis. (britannica.com)
Activation of TRPV1 by capsaicin caused significant inhibition of cancer cell growth and induced apoptosis and necrosis. (dovepress.com)
Finally, further experimental research studies are needed to evaluate the complex mechanisms by which lead may cause cancer with particular emphasis on the roles of oxidative stress / apoptosis and the roles of cellular defense mechanisms, signaling pathways and intracellular lead binding patterns in mediating these processes. (who.int)

The target mRNAs in the Argonaute2 (Ago2) complex of nucleus and cytoplasm of gastric cancer cells were analyzed through Gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) analysis. (biomedcentral.com)
The target genes of miRNAs in the Ago2 complexes of nucleus and cytoplasm played important roles in cell proliferation, cell differentiation, innate immune response and tumorigenesis. (biomedcentral.com)
Cancers occur when genetic mutations build up in critical genes, specifically those that control cell growth and division (proliferation) or the repair of damaged DNA. (medlineplus.gov)
Somatic mutations in many different genes have been found in parathyroid cancer cells. (medlineplus.gov)
In people with germline mutations, changes in other genes, together with non-genetic factors, also influence whether a person will develop parathyroid cancer. (medlineplus.gov)
To achieve this, p53 mainly functions as a transcription factor (TF) targeting hundreds of genes, but it also has TF-independent roles in the nucleus and cytoplasm [ 6 ]. (nature.com)
But viral vectors are risky--they can enter the nucleus during cell division and disrupt genes. (the-scientist.com)
We have found a connection between the cancer cell 'swallowing' certain molecules and its ability to activate tumor suppressor genes," says study author Sofia Merajver, M.D., Ph.D., professor of internal medicine and epidemiology at the University of Michigan. (eurekalert.org)
PTEN and other tumor suppressor genes are desirable targets for cancer therapy, but they have proven elusive: no drugs have yet been found to restore function of these mutated or deleted genes. (eurekalert.org)
Using a sophisticated form of RNA sequencing they compared lung cancer cells engineered to over-express GRP78 in the nucleus to cells lacking GRP78 in the nucleus in order to learn which genes were affected. (news-medical.net)
To our big surprise, we found that the key genes being regulated by GRP78 in the nucleus are mainly involved with cell migration and invasion,' Lee said. (news-medical.net)
He adds that this could shed light on why cancers can develop despite apparently normal p53 genes. (newscientist.com)
This is consistent with the notion that many divergent cancers share a limited number of disease mechanisms with common underlying signaling networks, despite the many genes implicated in the disease. (rochester.edu)
When T cells are activated, histone modifications take place which, on one hand, condense DNA and prevent transcription of genes ensuring longevity, while on the other hand open up and allow transcription of genes driving their inflammatory and killing function. (unige.ch)
Inside the nucleus, HER family members (EGFR, HER2, and HER3) have been shown to function as co-transcriptional activators for various cancer-promoting genes. (plos.org)
Finally, transcription factors within the nucleus must initiate the transcription of genes involved in cell proliferation. (britannica.com)
They're believed to work by blocking cell metabolism through their effect on specific genes. (lls.org)
Mutations in 11 genes are linked to aggressive forms of prostate cancer, which may present novel therapeutic and therapy options. (medindia.net)
Chromosomes are the cellular storage units for genes contained within the nucleus (which is the genetic center) of the cell and are analogous to a spool with the DNA or genetic message being the thread on the spool. (sarcomahelp.org)
Humans have a duplicate set of 23 chromosomes (or a total of 46 chromosomes) in any given cell that carries all of the human genes. (sarcomahelp.org)
A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility. (who.int)

Extracellular ST6GAL1, present in cancer exosomes or the freely soluble recombinant sialyltransferase, compensates for insufficient intrinsic ST6GAL1 by boosting cancer cell proliferation and increasing invasiveness. (nature.com)
Our data indicate that extracellular ST6GAL1 from remote sources can compensate for cellular ST6GAL1-mediated aggressive tumor cell proliferation and invasive behavior and has great clinical potential for extracellular ST6GAL1 as these molecules are in the extracellular space should be easily accessible targets. (nature.com)
This drug specifically inhibits BRAFV600E, a mutated protein that drives cancer cell proliferation. (medindia.net)
Interestingly, stimulation of CysLT1R located in the nuclei induced the activation of ERK1/2, an enzyme which have been shown to mediate LTD4 induced proliferation. (lu.se)
Overview of Cancer Cancer is an unregulated proliferation of cells. (msdmanuals.com)

whereas human epidermal growth factor receptor 2 (HER2)-positive breast cancers can be targeted by specific drugs, the triple-negative breast cancer phenotype is defined by chromosomal instability and low expression levels of estrogen receptor (ER) alpha, progesterone receptor (PR), and HER2, rendering treatment rather difficult. (dovepress.com)

A necessary step for improving space radiation cancer risk assessment is to perform studies on the molecular pathways that can cause cancer initiation and progression, and to extend these studies to learn how such pathways can be disrupted by HZE ions, including both genetic and epigenetic modifications that are noted as the hallmarks of cancer (Figure 4-8). (wikipedia.org)
Telomere dysfunction plays a crucial role in initiating or sustaining genomic instability, which is a major step in cancer progression. (wikipedia.org)
This conundrum brings to question whether cancer ST6GAL1 overexpression is beneficial or ultimately detrimental to long-term patient outcomes and highlights the incomplete mechanistic understanding of how ST6GAL1 is involved in cancer progression. (nature.com)
It is within the cell-autonomous context that ST6GAL1 involvement in cancer progression has been interpreted. (nature.com)
Cancer cell-extrinsic mechanisms, which are poorly understood, are also believed to contribute to disease progression and the heterogeneous genetic mutations with diverse presentations. (nature.com)
Apart from CSCs, there are a myriad of factors and interactions between various cell types and the tumor microenvironment (TME) that ultimately affect CCA progression. (springer.com)
These very close relationships, among very diverse research areas, allow us to bring in technologies from many different angles, and allow breakthroughs to understanding the mechanisms of metabolism in cancer - its progression, metastasis and the immune response - and also come up with new ways to target it. (princeton.edu)
This family of RTKs has been highly implicated in the formation and progression of various cancers via aberrant overexpression, kinase activation, and mutation [1] , [2] . (plos.org)
A new laboratory tool will allow researchers to study the progression from normal cells to myelodysplastic syndromes to an aggressive type of leukemia. (sloankettering.edu)
2 - 4 Expression profiling on a genomic scale led to the classification of the intrinsic subtypes of breast cancer, thus allowing for the prediction of disease progression and patient stratification. (dovepress.com)
Accumulation of Tumor-Associated Macrophages (TAMs) is associated with tumor progression and poor survival in most cancers, including breast cancer. (lu.se)

However, a comprehensive view of miRNAs and mRNAs in cytoplasm and nucleus has not been explored. (biomedcentral.com)
This study aims to reveal the mechanisms of miRNA-RNA interactions in nucleus and cytoplasm. (biomedcentral.com)
In this study, the miRNAs and their target mRNAs in the Argonaute2 (Ago2) complex of nucleus and cytoplasm of gastric cancer cells were characterized using high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP). (biomedcentral.com)
The results revealed that there were 243 miRNAs and 265 miRNAs in the Ago2 complexes of nucleus and cytoplasm, respectively. (biomedcentral.com)
microRNA-mRNA interactions occur in nucleus and cytoplasm of gastric cancer cells. (biomedcentral.com)
Therefore, our study demonstrated that miRNA-mRNA interactions not only took place in cytoplasm but also in nucleus. (biomedcentral.com)
The cells are polyhedral and have abundant granular cytoplasm with well-defined cell borders. (medscape.com)
[ 2 ] Oncocytic cells in the thyroid are often called Hürthle cells, and oncocytic change is defined as cellular enlargement characterized by an abundant eosinophilic granular cytoplasm as a result of accumulation of altered mitochondria. (medscape.com)
They have a large pleomorphic hyperchromatic nucleus, a prominent nucleolus, and intensely pink, fine, granular cytoplasm with hematoxylin-eosin staining. (medscape.com)

We found that shRNA knockdown of intrinsic ST6GAL1 expression resulted in decreased ST6GAL1 cargo in the exosome-like vesicles as well as decreased breast tumor cell growth and invasive behavior in 3D in vitro cultures. (nature.com)
Aggressive breast cancer is a highly heterogeneous disease caused by a variety of distinct cell-intrinsic genetic alterations in mammary epithelial cells, leading to vastly heterogenic disease manifestation in individual patients and predominantly affecting patient prognosis and treatment options [ 14 ]. (nature.com)
Ductal carcinoma in situ (DCIS) is noninvasive breast cancer that is limited to the inside of the ducts of the breast. (medscape.com)
Women with low-grade DCIS are at higher risk of developing invasive breast cancer than women without DCIS, but are less likely to have a recurrence of the breast carcinoma or to develop new cancers than women with higher-grade DCIS. (medscape.com)
Low-grade DCIS cells appear very much like normal breast cells or atypical ductal hyperplasia cells. (medscape.com)
Breast cancer. (medscape.com)
Lobular carcinoma in situ (LCIS) is noninvasive breast cancer that arises from the lobule at the terminal end of the duct and shows a rather diffuse distribution throughout the breast, which explains its presentation as a nonpalpable mass in most cases (see the images below). (medscape.com)
In this study, published in the Journal of Cell Science , researchers looked at breast cancer cells that did not express PTEN, a protein known to be mutated or deleted in about a third of breast cancers. (eurekalert.org)
The study of two cases of ductal carcinoma in situ in breast tissue supports the biological observation regarding the existence of a preferential intraductal invasion, and therefore a common origin, between the primary tumor and the gene amplification in the cell-nuclei lining the ductal structures in the breast. (nih.gov)
This 3D image of human breast cancer bone metastases shows the formation of the newly described organelle (magenta) in cancer cells (cyan). (princeton.edu)
Clinical breast exams are not recommended for breast cancer screening in average-risk women at any age. (medscape.com)
While not recommending breast self-exams as part of a routine breast cancer screening schedule, the ACS does advise that, "Women should be familiar with how their breasts normally look and feel and should report any changes to a health care provider right away. (medscape.com)
For women at high risk, the ACS recommends breast cancer screening with breast MRI and a mammogram every year, typically starting at age 30 and continuing for as long as they are in good health. (medscape.com)
In 2016, the USPSTF released updated recommendations on breast cancer screening, but did not update its 2009 recommendations for breast examination. (medscape.com)
however, no study has examined the expression profiles of human TRP channels in breast cancer on a large scale. (dovepress.com)
Next-generation sequencing analyses revealed the expression of TRPV1 in several native breast cancer tissues, which was subsequently validated via reverse transcriptase-polymerase chain reaction. (dovepress.com)
In this study, stimulation by the TRPV1 agonist, capsaicin, of SUM149PT cells, a model system for the most aggressive breast cancer subtype, triple-negative breast cancer, led to intracellular calcium signals that were diminished by the specific TRPV1 antagonist, capsazepin. (dovepress.com)
In conclusion, the current study revealed the expression profiles of human TRP channels in 60 different breast cancer tissues and cell lines and furthermore validated the antitumor activity of TRPV1 against SUM149PT breast cancer cells, indicating that activation of TRPV1 could be used as a therapeutic target, even in the most aggressive breast cancer types. (dovepress.com)
Breast cancer is one of the most common cancers affecting women worldwide. (dovepress.com)
5 Triple-negative breast cancer is characterized by limited treatment options and frequent local recurrence. (dovepress.com)
Here, using human and mouse breast cancer cell lines, we found that oncogene forkhead box M1 (FOXM1) interacts with SMAD3 to sustain activation of the SMAD3/SMAD4 complex in the nucleus. (jci.org)
We found that FOXM1/SMAD3 interaction was required for TGF-β-induced breast cancer invasion, which was the result of SMAD3/SMAD4-dependent upregulation of the transcription factor SLUG. (jci.org)
Furthermore, FOXM1 levels correlated with activated TGF-β signaling and metastasis in human breast cancer specimens. (jci.org)
Together, our data indicate that FOXM1 promotes breast cancer metastasis by increasing nuclear retention of SMAD3 and identify crosstalk between FOXM1 and TGF-β/SMAD3 pathways. (jci.org)
About 25,000 Canadian women are diagnosed with breast cancer annually. (sunnybrook.ca)
furthermore, deaths from breast cancer have decreased by 44% since 1986 due to earlier detection and better treatments. (sunnybrook.ca)
Researchers from Brigham and Women's Hospital in Boston, U.S. have found thousands of women with breast cancer are removing a healthy breast as a preventive measure without evidence that doing so is beneficial. (sunnybrook.ca)
She's looking at ductal carcinoma in situ (DCIS), where cancer is confined to the lining of the milk ducts, and the most common type of noninvasive breast cancer. (sunnybrook.ca)
The downside: DCIS raises the risk of developing an invasive breast cancer. (sunnybrook.ca)
Doctors can only estimate this risk using factors including a patient's age and tumour size-an approach that's unreliable, according to Rakovitch, who is also the medical director of the Louise Temerty Breast Cancer Centre at Sunnybrook. (sunnybrook.ca)
Knowing which women with DCIS are most likely to develop invasive breast cancer could change all that. (sunnybrook.ca)
A new study led by researchers suggests that an unusual experimental drug can reduce breast-cancer aggressiveness, reverse resistance to the drug fulvestrant. (medindia.net)
They used CRISPR/Cas9 to directly test the effects of knocking out YME1L1 in the breast cancer cell line MCF-7 . (yeastgenome.org)
Invasive ductal carcinoma is the most commonly diagnosed breast cancer and has a tendency to metastasize via lymphatics. (medscape.com)
OBJECTIVES: To develop and validate an ultrasound (US) radiomics-based nomogram for the preoperative prediction of the lymphovascular invasion (LVI) status in patients with invasive breast cancer (IBC). (bvsalud.org)
CLINICAL RELEVANCE STATEMENT: The US radiomics-based nomogram incorporating menopausal status, posterior echo features, US reported-ALN status, and radiomics signature has the potential to predict lymphovascular invasion in patients with invasive breast cancer. (bvsalud.org)
Importantly, pro-tumoral perivascular TAMs in breast cancer (BC) are associated with poor prognosis and increased risk of distant metastasis ( Figure 2 ). (lu.se)

In hormonally nonfunctional parathyroid cancer, the cause of death is typically related to the tumor itself, such as its impact on the function of nearby structures or its spread to other tissues ( metastasis ). (medlineplus.gov)
Hematogenous metastasis contributes to a poor patient prognosis in many types of cancer, with over 90% of cancer-related death attributed to metastasis (1). (aiche.org)
For metastasis to occur, cancer cells detach from the primary tumor, invade through the basement membrane, and intravasate into the peripheral circulation as circulating tumor cells (CTCs) (2). (aiche.org)
Cancer stem cells (CSCs) are thought to the underlying reason for cancer initiation, metastasis, and relapse. (springer.com)
Princeton cancer researchers Yibin Kang (left) and Mark Esposito, seen here in April 2019, discovered a new, still-unnamed organelle that plays a role in bone metastasis and is formed via liquid-liquid phase separation - when liquid blobs of living materials merge into each other. (princeton.edu)
We believe this is the first time that phase separation has been implicated in cancer metastasis," said Kang. (princeton.edu)
By targeting these mechanisms, the overarching aim is to reprogram pro-tumoral TAMs into an anti-tumoral state, affecting various components of the non-cancer cells residing in the tumor microenvironment, ultimately inhibiting tumor growth and metastasis ( Figure 1 ). (lu.se)
Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)

Studies with protons and HZE nuclei of relative biological effectiveness for molecular, cellular, and tissue endpoints, including tumor induction, demonstrate risk from space radiation exposure. (wikipedia.org)
Atomic Number -- The number of protons in the nucleus of a neutral atom of a nuclide. (cdc.gov)
Alpha particle ( ionizing radiation ) - two neutrons and two protons bound as a single particle (a helium nucleus) that is emitted from the nucleus of certain radioactive isotopes in the process of disintegration. (cdc.gov)
Atomic number - the number of protons in the nucleus of an atom. (cdc.gov)

This image shows an osteosarcoma cell with DNA in blue, energy factories (mitochondria) in yellow, and actin filaments, part of the cellular skeleton, in purple. (nih.gov)
Accurate results of cell nuclei segmentation are often adapted to a variety of applications such as the detection of cancerous cell nuclei and the observation of overlapping cellular events occurring during wound healing process in the human body. (hindawi.com)
In this study, the antitumor effects of terpinen-4-ol and the cellular and molecular mechanisms responsible for it were evaluated and studied, respectively on human nonsmall cell lung cancer (NSCLC) cells. (hindawi.com)
This presentation describes the current state of the stem cells marketplace as it relates to their utilization for pharmaceutical screening as well as their development for cellular therapy. (selectbiosciences.com)
For decades scientists have been trying to reproduce cell culture environment for the closest mimicry of the natural cellular "embedding" within a living organism. (selectbiosciences.com)

DSRCT is composed of small cells with round hyperchromatic nuclei and a dense fibrous or spindle cell stroma. (medscape.com)

Novel multicolor fluorescence painting techniques of human chromosomes have clearly demonstrated that high-LET α-particles and Fe-ions induce many more complex rearrangements will ultimately lead to cell death. (wikipedia.org)
Classically, HER family members function from the cell surface, where binding to cognate ligands can induce receptor homo- or hetero-dimerization with other HER family receptors [3] . (plos.org)
When activated, iASPP is shuttled into the nucleus, binds to p53 and ultimately inhibits its ability to induce cell suicide. (medindia.net)
In order to induce its effects on the intestinal epithelial cells, LTD4 binds to its receptor CysLT1R. (lu.se)
The nanotube bundles are similar to the potential of nanotubes to induce genetic damage size of microtubules that form the mitotic spindle in normal lung cells, cultured primary and immor- and may be incorporated into the mitotic spindle talized human airway epithelial cells were apparatus. (cdc.gov)

A team of researchers led by UF Health Cancer Center member Xin Tang, Ph.D. , assistant professor in the department of mechanical & aerospace engineering, has developed a new biophysics technique to shed light on the mechanobiology of the nucleus in single cancer and normal cells. (ufl.edu)
The researchers designed, fabricated and implemented a new magnetic force actuator that applies precise and noninvasive 3D mechanical stimuli to directly deform the cell nucleus. (ufl.edu)
These new methodologies will enable researchers to elucidate previously inaccessible mechano-regulated gene expression, chromosome organization and transcription activities in the contexts of cell physiology and pathobiology, including cancer, immunodeficiency and diabetes. (ufl.edu)
Androgen receptor (AR) signaling continues to play a dominant role in all stages of prostate cancer (PC), including castration-resistant prostate cancers (CRPC) that have developed resistance to second-generation AR antagonists such as enzalutamide," the researchers wrote. (genengnews.com)
The Biomarker Discovery Lab aims to meet these evolving needs and provide a resource for both clinical and basic science researchers at the Mass General Cancer Center. (massgeneral.org)
The researchers hope that by understanding the role of PTEN at a mechanistic level - what are the steps that cause PTEN to modulate how cancer cells communicate with the outside - it could provide a new approach to targeting the consequences of decreased function of this critical tumor suppressor. (eurekalert.org)
The researchers plan to look at the signaling in other types of cancer where PTEN plays a role to gain a better understanding of the signaling impact. (eurekalert.org)
Next, the researchers set out to learn more about what happens in a cell after GRP78 enters the nucleus. (news-medical.net)
The tool enables the researchers to study individual biomolecules as well as important global patterns of gene expression, which could yield insights into cancer. (news-medical.net)
ONE of the mechanisms that make damaged cells commit suicide is switched off in the embryo, say researchers. (newscientist.com)
Researchers irradiated stem cells from mouse embryos to cause genetic mutations, then stained the cells to reveal the tumour suppressing protein p53. (newscientist.com)
SKI researchers have learned how tiny droplets prevent a cancer-causing type of messenger RNA from being degraded in leukemia cells. (sloankettering.edu)
Researchers identify a compound that appears to eliminate tumor cells in a dish and in mice. (sloankettering.edu)
These researchers searched through whole genomes of colon adenocarcinoma patients and found that these cancer cells had 4.2-fold more mtDNA insertions compared to noncancerous cells from the same patient. (yeastgenome.org)
Detailed genetic and epigenetic sequencing now form the basis of the hunt by cancer researchers for diagnostically useful changes. (lu.se)

The T7 vector never enters the nucleus, and it continuously produces the enzyme. (the-scientist.com)

Previous studies from the same team, led by Amy S. Lee, PhD, professor of biochemistry and molecular medicine at the Keck School of Medicine of USC, have shown that when cells are under stress (due to COVID-19 or cancer), GRP78 gets hijacked, allowing viral invaders to replicate, and cancers to grow and resist treatment. (news-medical.net)
Resveratrol's anti-cancer capability has attracted widespread attention, but its molecular mechanism has not been systematically explained. (mdpi.com)
Cancer biologist Michael Kharas explores molecular processes that stem cells and tumor cells have in common. (sloankettering.edu)
Cell and Molecular Biology helps biologists make important connections between key concepts and experimentation. (chipsbooks.com)
Thomas RK, Re D, Wolf J, Diehl V. Part I: Hodgkin's lymphoma--molecular biology of Hodgkin and Reed-Sternberg cells. (medscape.com)

These techniques allowed them to identify the signal within GRP78 that enables it to enter the nucleus and confirm that when GRP78 is present in the nucleus, it stimulates EGFR gene activity. (news-medical.net)

The primary tasks involved in the analysis of histologically stained tissue sections are cell nuclei counting, detecting abnormal cell nuclei, and the presence of antigens within the target cells. (hindawi.com)
SFTs of the pleura are localized mesenchymal neoplasms composed of fibroblastlike cells believed to arise from the subpleural connective tissue. (medscape.com)
David T. Ting MD is a translational cancer researcher with experience in tissue image analysis and next generation sequencing. (massgeneral.org)
In some cases, proton therapy may be useful in treating cancer that has metastasized, or spread into surrounding tissue, due to its focused dose advantages. (newswise.com)
Conventional radiation can help cure a child's cancer, but it carries an increased risk of damage to surrounding tissue. (newswise.com)
Multiple Myeloma Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (msdmanuals.com)
We are using large-scale single-nuclei RNA-sequencing of postmortem tissue to investigate the pathological role of transposons in both acute neurodegeneration occurring after traumatic brain injury as well as in progressive neurodegeneration in Parkinson's disease. (lu.se)

To address this issue, we have designed an integrated image analysis software system for high-throughput segmentation of nuclei. (nih.gov)
1 A series of high-throughput methods have changed cancer research and therapy. (dovepress.com)

The findings, just published in the Proceedings of the National Academy of Sciences, could represent a paradigm shift for cell biology, and have implications for cancer therapeutics research, Lee said. (news-medical.net)
The discovery that GRP78, a major endoplasmic reticulum protein, can travel to the nucleus and assume new functions, could also have broad implications across the field of cell biology. (news-medical.net)
This has notable implications for the treatment of cancers in which p53 is not mutated but is instead functionally silenced roughly half of all cancer cases. (medindia.net)

The present work reports for the first time the HPLC analysis and in vitro antioxidant evaluation of mango peel phenols (MPPs) and their cytotoxic effect on the A549 lung cancer cell line. (mdpi.com)
To confirm their hypothesis, Liu, Lee and their colleagues used confocal microscopy, which offers high-resolution 2D and 3D imaging, coupled with an advanced technique for capturing images of live cells, to directly observe GRP78 in the nucleus of lung cancer cells, as well as normal cells under stress. (news-medical.net)
The new findings point to several potential new approaches for cancer treatment, including down-regulating the activity GPR78 to suppress EGFR in lung cancer, or preventing it from binding to ID2. (news-medical.net)
Lung cancer is the leading cause of cancer-related deaths worldwide. (hindawi.com)
Among lung cancers, nonsmall cell lung carcinomas (NSCLC) account for approximately 80% of lung cancer cases [ 1 ]. (hindawi.com)
In addition, there is no report on the antitumor effects of terpinen-4-ol against human nonsmall cell lung cancer cells. (hindawi.com)
Experimental studies are needed to elucidate the biological mechanisms between particle-induced inflammation and lung cancer. (cdc.gov)
A study examining the relationship between TiO2 exposure in workers and validated markers of oxidative stress, with quantitative comparison in rodent studies, could provide data on interpretation of the animal studies for predicting lung cancer risk in humans. (cdc.gov)
2005) suggests that possible direct genotoxic mechanisms for lung cancer should be examined. (cdc.gov)
Risk of lung cancer according to mild steel and stainless steel welding. (who.int)
Winter PD, Gardner MJ, Fletcher AC, Jones RD. A mortality follow-up study of pottery workers: preliminary findings on lung cancer. (who.int)

The cells were stained with an anti-SMAD3 or anti-SMAD4 antibody and then by a rhodamine-conjugated anti-mouse secondary antibody (red, for SMAD4) or a FITC-conjugated anti-rabbit secondary antibody (green, for SMAD3), and the nuclei were visualized with DAPI (blue). (jci.org)
Immunofluorescence staining of CD31+ vessels (red), CD68+ TAMs (green) and DAPI stained cell nuclei (grey) in ER+ BC. (lu.se)

Under AAS culture conditions, the cell killing effect of GEF was synergistically pronounced in the EGFR-expressing cell lines, namely, CAL 27, Detroit 562, A549 and PANC-1 cells compared with those treated with either GEF or AAS alone. (spandidos-publications.com)
Ze Liu, PhD, a postdoctoral researcher in Lee's lab and the study's first author, was analyzing how GRP78 regulates a gene known as EGFR , long linked to cancer. (news-medical.net)
He noticed something surprising: GRP78 controls the gene activity of EGFR , raising the intriguing possibility that GRP78 may have entered the nucleus and assumed a new role. (news-medical.net)

Macroautophagy (thereafter designated as autophagy) is a self-digestive system conserved in all eukaryotic cells. (spandidos-publications.com)
Nucleolus is an important structure inside the nucleus in eukaryotic cells. (umassmed.edu)

Their findings are published in the journal Cancer Research in a paper titled, " Loss of long noncoding RNA NXTAR in prostate cancer augments androgen receptor expression and enzalutamide resistance . (genengnews.com)
Our findings revealed that different genetic backgrounds of HCT116 and HT29 cell lines resulted in divergent responses to the combination treatments. (frontiersin.org)
MSK investigators have used a lab tool originally developed to study fly nerve cells to uncover new findings about acute myeloid leukemia. (sloankettering.edu)
We will discuss our recent findings in the use of novel chemistry and physical energy, including radioelectric conveyed fields, to optimize stem cell expression of pluripotentiality. (selectbiosciences.com)

Uncovering key kinases in tumor growth and invasion is crucial for improving targeted therapies in advanced-stage colorectal cancer. (medindia.net)
Colorectal Cancer Colorectal cancer is extremely common. (msdmanuals.com)

Scientists in Western Switzerland have discovered how to improve the anti-tumour power of CAR-T cells, artificial immune ''super-cells'' used against blood cancers. (unige.ch)
Among available immunotherapies, the use of «CAR-T» cells is proving extremely effective against certain blood cancers, but only in half of patients. (unige.ch)
To investigate the role of reductive carboxylation, the scientists inhibited this mechanism in CAR-T cells in mouse models of leukaemia and multiple myeloma, two blood cancers. (unige.ch)
More than 50 drugs of different types are now being used singularly or in combination to treat blood cancers. (lls.org)
Some blood cancers are treated effectively with a single drug. (lls.org)

A cell nuclei segmentation algorithm incorporating unsupervised color clustering, morphological operations, and local thresholding has been proposed to distinguish the cancerous and noncancerous areas in histologically stained images and then segment the clustered cell nuclei [ 3 ]. (hindawi.com)
In this case, your doctor may prescribe different drugs to target and kill the cancerous cells. (lls.org)
When they become cancerous lymphoma cells, you cannot fight infection as easily. (lymphoma.org.au)
Hodgkin Lymphoma is identified when the cancerous B-cells develop in a certain way and become Reed-Sternberg cells - which look very different from normal B-cells. (lymphoma.org.au)

NAD-seq has been used to study the biological functions of NAD and the dynamics of NAD distribution during embryonic stem cell (ESC) differentiation. (umassmed.edu)
But the disease history of the patient, in combination with the amplification process, exhausts the cells: they reach a state of terminal differentiation that precipitates the end of their life cycle without leaving them time to act on the length. (unige.ch)
The state of differentiation of CAR-T cells is therefore a key factor in the success of the treatment. (unige.ch)
therefore, definitive differentiation of Hürthle cell carcinoma from Hürthle-cell adenoma is based on vascular invasion and/or capsular invasion, as well as on permanent histologic sections or extrathyroidal tumor spread and lymph node and systemic metastases. (medscape.com)

We also discuss the possibility of targeting p53-mediated ferroptotic responses for the treatment of human cancers and potentially, other diseases. (nature.com)
The sialyltransferase ST6GAL1 that adds α2-6 linked sialic acids to N-glycans of cell surface and secreted glycoproteins is prominently associated with many human cancers. (nature.com)

The inhibitor used by the scientists to block reductive carboxylation is a drug already approved for the treatment of certain cancers. (unige.ch)
Bisphosphonates are used to treat high levels of calcium in the blood caused by certain cancers, including myeloma. (lls.org)

It was previously difficult to access and quantify nucleus mechanics with conventional tools, resulting in a gap in knowledge on the relationship between nucleus mechanotransduction and cell function. (ufl.edu)
However, as the result of recent advancements in microscopic imaging technology and computational image processing techniques [ 1 ], there has been significant growth of research towards translational computational systems that can detect, analyze, classify, and quantify cell nuclei from microscopic images. (hindawi.com)

Cells use a number of mechanisms to sense and maintain their homeostatic levels. (spandidos-publications.com)
When it comes to the basic mechanisms of cancer cells, this is something novel that, to my knowledge, no one has observed before. (news-medical.net)
Transient receptor potential (TRP) channels contribute to the regulation of intracellular calcium, which can promote cancer hallmarks in cases of dysregulation of gene transcription and calcium-dependent pro-proliferative or anti-apoptotic mechanisms. (dovepress.com)

He is the senior author on a new paper featured on the cover of the current issue of Nature Cell Biology. (princeton.edu)
Using a wide variety of experimental approaches, including genomics and systems biology, the laboratory has demonstrated that the cooperation of cancer-promoting genetic lesions is strongly reflected by synergistic modulation in signaling and the gene networks of malignant cells. (rochester.edu)
Three emerging investigators are tackling the mysteries of biology and cancer at Memorial Sloan Kettering. (sloankettering.edu)

Statistical analysis of genetic changes within cell nuclei that are far from the primary tumor would help determine whether such changes have occurred prior to tumor invasion. (nih.gov)
Nuclear localized HER family receptor tyrosine kinases (RTKs) have been observed in primary tumor specimens and cancer cell lines for nearly two decades. (plos.org)

The observation of inhaled discrete nanoscale TiO2 particles inside rat alveolar epithelial cell organelles including the nucleus (Geiser et al. (cdc.gov)
Co-staining for an epithelial cell marker identified most WUPyV viral protein 1-positive cells as respiratory epithelial cells. (cdc.gov)

Although the LAT family plays important roles in the development and function of normal tissues, they are frequently increased in cancer cells ( 3 ). (spandidos-publications.com)
Subsequent research has revealed that the Wnt signaling pathway plays multiple roles in healthy bone growth as well as in cancer metastasizing to bones. (princeton.edu)

There are currently no approved therapies for hormone-refractory prostate cancer. (sbir.gov)
According to the research - conducted in mice implanted with human prostate tumor samples - restoring this so-called long noncoding RNA could be a new strategy to treat prostate cancer that has developed resistance to hormonal therapies. (genengnews.com)
Although many patients with prostate cancer are treated with therapies that block hormones that fuel tumor growth, most patients develop resistance to these therapies. (genengnews.com)
We are hoping to develop both this (R)-9b drug and NXTAR into new therapies for prostate cancer patients who have developed resistance to the front-line treatments," Mahajan said. (genengnews.com)
The finding could open up a potential new avenue to pursue new therapies against cancer. (eurekalert.org)
However, many conventional and investigational drug therapies combine drugs that attack cancer cells at different points in their growth cycles. (lls.org)
Since multiple signaling pathways drive the growth of tumor cells, Lu and her colleagues wondered if the restoration of p53 function could be used as a strategy to enhance existing cancer therapies that target parallel signaling pathways. (medindia.net)

Although, non-psychoactive cannabidiol (CBD) and cannabigerol (CBG) display antineoplastic effects by repressing tumor growth and angiogenesis both in cell line and animal models, their use as chemotherapeutic agents is awaiting further investigation. (frontiersin.org)
Furthermore, treatment of s.c xenografts derived from A549 cells with intratumor injections of terpinen-4-ol significantly inhibited tumor growth compared with the control group. (hindawi.com)
These TAMs further stimulate activation of cytotoxic T cells that kill tumor cells, resulting in suppression of tumor growth. (lu.se)

DESCRIPTION (provided by applicant): Human embryonic stem cells (HuES) have the potential to generate an unlimited source of beta/islet cells for transplantation, however the biologic factors required for this process have been difficult to ascertain partly due to the lack of stage specific in vitro cell assays. (sbir.gov)
Cancer stem cells (CSCs) represent a small subset of the tumor population and reside at the apex of the hierarchy [ 9 ]. (springer.com)
Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells. (rochester.edu)
Research in blood stem cells has revealed new information about how these cells decide what to become when they divide. (sloankettering.edu)
We are working to generate red blood cells in vitro from pluripotent stem cells, however the extremely large cell numbers involved pose unique challenges to culture technology and scale-up. (selectbiosciences.com)
Novel culture and cryopreservation systems for human pluripotent stem cells and neural stem cells will be presented and their advantages and applicability in the production of high quality advanced therapeutic products or functional screening tools for preclinical research discussed. (selectbiosciences.com)
We also use human induced pluripotent stem cells to investigate how polymorphic transposable elements contribute a genetic component to these disorders, using X-linked dystonia Parkinsonism as our current focus. (lu.se)

Pictured are prostate cancer cells. (genengnews.com)
The scientists uncovered that prostate cancers develop ways to stop this RNA molecule to allow themselves to grow. (genengnews.com)
The drugs that we have to treat prostate cancer are effective initially, but most patients start developing resistance, and the drugs usually stop working after a year or two," explained senior author Nupam P. Mahajan, PhD, a professor of surgery in the division of urologic surgery. (genengnews.com)
In prostate cancer, the androgen receptor is very clever," said Mahajan, who is also a research member of Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine. (genengnews.com)

Hormonally nonfunctional parathyroid cancer has a lower survival rate because it is often found at a later stage, as it does not have early signs such as increased calcium and parathyroid hormone levels. (medlineplus.gov)
Individuals with CDC73 gene mutations are also at a higher risk of recurrence of the cancer and have a decreased survival rate compared to those without CDC73 gene mutations. (medlineplus.gov)
Previous studies have juxtaposed and analyzed immune cell compartments between different CCA categorizations such as short or long-term overall survival (OS) [ 16 ]. (springer.com)
Improved oral health, as indicated by the count of natural teeth and dental appointments preceding the diagnosis, correlated with enhanced head and neck cancer survival rates. (medindia.net)

Cell nuclei from both cancer cells and normal bone cells are labeled in blue. (princeton.edu)
Bisphosphonates won't slow or stop the spread of cancer, but they can slow bone breakdown, increase bone thickness and reduce bone pain and fracture risk. (lls.org)
He observed that this highly aggressive bone cancer was remarkably sensitive to radiation therapy. (sarcomahelp.org)
This image taken by the new microscope shows a living bone cancer cell with nucleus (blue), mitochondria (green) and cytoskeleton (magenta). (digitaltrends.com)

Perhaps this was true in mammalian cells as well. (yeastgenome.org)

Nonmesotheliomatous cancers of the pleura include an assortment of malignant neoplasms that primarily or secondarily involve pleura. (medscape.com)
LAT-1 is most commonly upregulated in multiple types of cancer and has also been used as a biomarker for malignant cancer ( 4 , 5 ). (spandidos-publications.com)
The Land laboratory has pioneered investigation of the nature and underlying principles of cancer gene cooperation originating with the discovery that multiple oncogenic mutations are required for malignant cell transformation. (rochester.edu)

Patients suffering from IBD have been found to have an increased risk of developing colon cancer. (lu.se)
Since leukotrienes have been shown in increased concentrations in stools of IBD patients we hypothesise that LTD4 can play a role in the development of colon cancer. (lu.se)
We therefore chose to study CysLT1 in colon cancer specimens and in non-transformed and colon cancer cell lines. (lu.se)
Our results show that CysLT1R can be found in increased levels in colon cancer enterocytes (50% of 84 patients) and that high expression of this receptor in Dukes`B staged tumours predicts a poor disease outcome. (lu.se)
Sometimes the first indication is an abnormal laboratory test result (eg, anemia resulting from colon cancer). (msdmanuals.com)

Alpha Particle -- A charged particle emitted from the nucleus of an atom. (cdc.gov)
Beta particle ( ionizing radiation ) - a charged particle emitted from the nucleus of certain unstable atomic nuclei (radioactive isotopes), having the charge and mass of an electron. (cdc.gov)

The combination of the personalized cancer vaccine with ACT led to ovarian cancer control in few patients within a span of three months, stated study results. (medindia.net)
Ovarian, Fallopian Tube, and Peritoneal Cancer Ovarian cancer is often fatal because it is usually advanced when diagnosed. (msdmanuals.com)
The most common histology-high-grade serous epithelial ovarian cancer-is considered as a single clinical entity along. (msdmanuals.com)

Designation as low- and intermediate-grade DCIS implies that the cancer cells are growing at a relatively slow rate. (medscape.com)

First, a growth factor must bind to its receptor on the cell membrane . (britannica.com)
Third, this activation must stimulate a signal to be transmitted, or transduced, from the receptor at the cell surface to the nucleus within the cell. (britannica.com)
Transient receptor potential (TRP) channels, which are membranous ion channels that conduct calcium and sodium ions, have been shown to influence cancer cell growth. (dovepress.com)

Once activated, p53 coordinates multiple downstream pathways, thereby maintaining the homeostasis of the host cell or organism (if the stress is mild, transient, and repairable) or eliminating damaged cells (if the stress is acute, prolonged, and difficult to resist). (nature.com)

Cells on their own are microscopic - meaning they are so small we can not see them. (lymphoma.org.au)

Stained endocrine cell nuclei are segmented by a sequential thresholding algorithm that uses a Support Vector Machine (SVM) type of artificial neural network [ 9 ]. (hindawi.com)

In fact, only a small fraction of the initial damage is transduction of late chromosomal damage has also been measured in the progeny of human lymphocytes that were exposed with much higher frequency in the progeny of cells that were exposed to heavy ions compared to gamma rays. (wikipedia.org)
CAR-T cell immunotherapy involves taking immune cells - usually T lymphocytes - from a person suffering from cancer, modifying them in the laboratory to increase their ability to recognise and fight tumour cells, then readministering them to the patient. (unige.ch)
And even, and this is the heart of our discovery, they tend to transform into memory T lymphocytes, a type of immune cell that retains the memory of the tumour elements that needs to be attacked. (unige.ch)
Lymphoma is a type of cancer that affects your blood cells called lymphocytes. (lymphoma.org.au)
Lymphocytes are a type of white blood cell that support our immune system by fighting infection and disease. (lymphoma.org.au)
Our lymphatic system is also where our B-cell lymphocytes make disease fighting antibodies. (lymphoma.org.au)
Our lymphocytes are white blood cells that are a big part of our immune system. (lymphoma.org.au)
Unlike our other blood cells, lymphocytes usually live in our lymphatic system rather than in our blood stream. (lymphoma.org.au)
T-cell lymphocytes. (lymphoma.org.au)
Hodgkin Lymphoma - all Hodgkin Lymphomas are lymphomas of B-cell lymphocytes. (lymphoma.org.au)
Non-Hodgkin Lymphoma (NHL) - these are lymphomas of all other B-cells or T-cell lymphocytes, including NK cells. (lymphoma.org.au)

Genomic instability has been observed both in vitro and in vivo in the progeny of cells that are irradiated with heavy ions in several model systems. (wikipedia.org)

In addition, computer programs usually predict targets on a genome-wide scale irrespective of mRNA and miRNA that are specific to tissues or cell lines. (biomedcentral.com)
The finding could help to explain how cancer arises in different tissues in the body. (newscientist.com)

One protein that keeps healthy cells from behaving this way is a tumor suppressor named p53. (medindia.net)

Ductal carcinoma in situ cells are circled. (sunnybrook.ca)

It can also be used to observe the way that viral particles move through a cell. (digitaltrends.com)

Seeing GRP78 in the nucleus controlling gene expression is a total surprise. (news-medical.net)
Insights into the workings of the chromatin folding code, which regulates patterns of gene expression, will help us better understand cancer and its ability to adapt to changing environments,' Backman said. (news-medical.net)

Lee and her colleagues have now made an unexpected discovery that may eventually enable scientists to protect cells from that hostile takeover. (news-medical.net)
In the April 25 issue of Cancer Cell , a research team, led by Xin Lu, PhD, Ludwig director and member at the University of Oxford and a team of scientists from both institutions, describes how p53 is silenced in advanced melanomas by a protein named iASPP, and applies that information to restore p53 function in such cells. (medindia.net)
As well as saving scientists time, the big advantage of a faster microscope it that it can be used to observe the movements of small objects like cell particles. (digitaltrends.com)

These noninvasive tools pave the way for direct and researcher-programmed epigenetic manipulation of the individual nucleus and other organelles in single cells, said Tang, who is also an affiliate faculty member in the J. Crayton Pruitt Family department of biomedical engineering. (ufl.edu)
Electron microscopy demonstrated that the CAL 27 cells treated with GEF under AAS culture conditions exhibited swelling of the cytosol and organelles with an increased number of autophagosomes and autolysosomes, but without chromatin condensation and nuclear fragmentation. (spandidos-publications.com)
Everybody goes to school, and they learn 'The mitochondria is the powerhouse of the cell,' and a few other things about a few organelles, but now, our classic definition of what's inside a cell, of how a cell organizes itself and controls its behavior, is starting to shift," he said. (princeton.edu)

Mutations in the CDC73 gene are found in up to 70 percent of cases of parathyroid cancer. (medlineplus.gov)
In people who have parathyroid cancer with CDC73 gene mutations, the cancer is seven times more likely to metastasize than is parathyroid cancer in affected individuals without CDC73 gene mutations. (medlineplus.gov)
Carcinogenesis is a process driven by multiple co-operating oncogenic mutations in which features of the cancer cell phenotype, such as proliferative advantage, only emerge as a result of the interplay between these mutations. (rochester.edu)
Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype. (rochester.edu)

Anatomy35

Organisms4

Diseases45

Chemicals and Drugs66

Analytical, Diagnostic and Therapeutic Techniques and Equipment54

Psychiatry and Psychology1

Phenomena and Processes49

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science6

Health Care18

Geographicals1

Tumors17

Proteins17

Cell's3

Pancreatic4

Melanoma cells4

Apoptosis15

Genes21

Proliferation5

Epidermal growth f1

Progression11

Cytoplasm9

Breast37

Metastasis8

Protons4

Cellular5

Hyperchromatic1

Induce5

Researchers15

Enters the nucleus1

Molecular5

Enter the nucleus1

Tissue7

High-throughput2

Implications3

Lung cancer11

DAPI2

EGFR3

Eukaryotic cells2

Findings4

Colorectal2

Blood cancers5

Cancerous4

Differentiation4

Human cancers2

Certain cancers2

Quantify2

Mechanisms3

Biology3

Primary tumor2

Epithelial cell2

Roles2

Therapies7

Tumor growth3

Stem cells7

Prostate4

Survival4

Bone4

Mammalian Cells1

Malignant3

Colon cancer5

Charged particle2

Ovarian3

Designation1

Receptor3

Acute1

Microscopic1

Endocrine1

Lymphocytes11

Vitro and in vivo1

Tissues2

Protein that keeps1

Ductal Carc1

Viral1

Gene expression2

Scientists3

Organelles3

Mutations4