• Luu-The V, Dufort I, Paquet N, Reimnitz G, Labrie F: Structural characterization and expression of the human dehydroepiandrosterone sulfotransferase gene. (t3db.ca)
  • Part I covers key laboratory manipulations, including DNA cloning, gene characterization, association of genes with disease, and methods for studying gene regulation and activities of gene products. (columbia.edu)
  • Bosch, B. J., van der Zee, R., de Haan, C. A. M. & Rottier, P. J. M. The coronavirus spike protein is a category I virus fusion protein: structural and purposeful characterization of the fusion core complicated. (viralstake.com)
  • Characterization of cDNA clones for human myeloperoxidase: predicted amino acid sequence and evidence for multiple mRNA species. (rusmedserv.com)
  • Sakamaki K, Tomonaga M, Tsukui K, Nagata S. Molecular cloning and characterization of a chromosomal gene for human eosinophil peroxidase. (rusmedserv.com)
  • Isolation and characterization of a cDNA clone for porcine thyroid peroxidase. (rusmedserv.com)
  • Kong AN, Yang L, Ma M, Tao D, Bjornsson TD: Molecular cloning of the alcohol/hydroxysteroid form (hSTa) of sulfotransferase from human liver. (t3db.ca)
  • This four-credit course will present a quantitative description of the molecular networks that underlie the myriad phenotypes of living cells, from yeast to human. (columbia.edu)
  • Lectures on these topics will be integrated with introductory lectures on molecular and structural biology, thermodynamics, statistics, and machine learning. (columbia.edu)
  • Molecular cloning of cDNAs encoding bovine and human lactoperoxidase. (rusmedserv.com)
  • Cattle Fc gamma RII: molecular cloning and ligand specificity. (uni-bielefeld.de)
  • We describe here the molecular cloning of IC1. (embl.de)
  • They rely on their target cell for molecular building blocks, energy sources and host factors to replicate, since viruses are gene poor compared to their host [1]. (fortunejournals.com)
  • 1990. Cell replication and unscheduled DNA synthesis (UDS) activity of low molecular weight chlorinated paraffins in the rat liver in vivo. (cdc.gov)
  • 50%. Overall, the molecular and biologic characteristics of the strain HSR1 provide evidence that SARS-CoV forms a for Vero cells (a continuous cell line established from mon- fourth genetic coronavirus group with distinct genomic and key kidney epithelial cells), its capacity for growth at 37°C biologic features. (cdc.gov)
  • Braude P., Bolton V., Moore S., Human gene expression first occurs between the four- , and eight-cell stages of preimplantation development. (biologie-journal.org)
  • Here we show the features of repertoire diversity and the gene expression profile of HLA-A24 cytomegalovirus-specific cytotoxic T-cells in actual recipients according to the cytomegalovirus reactivation pattern. (nature.com)
  • Single-cell RNA-sequence analyses demonstrate the homogenous distribution of the gene expression profile in individual cytomegalovirus-specific cytotoxic T-cells within each recipient. (nature.com)
  • On the other hand, bulk RNA-sequence analyses reveal that gene expression profiles among patients are different according to the cytomegalovirus reactivation pattern, and are associated with cytokine production or cell division. (nature.com)
  • However, little information is available on the gene expression profile (GEP) of CMV-CTL clones according to CMV reactivation patterns (and donor CMV serostatus) after allo-HCT. (nature.com)
  • Using his expertise in global gene expression profiling, he dissected gene regulatory networks involved in the maintenance of pluripotency of embryonic stem cells. (dna-chip.co.jp)
  • Dissecting Oct3/4-regulated gene networks in embryonic stem cells by expression profiling. (dna-chip.co.jp)
  • Cloning and nucleotide sequence of the simian rotavirus gene 6 that codes for the major inner capsid protein. (microbiologyresearch.org)
  • We have identified a novel gene, gtcA , involved in the decoration of cell wall teichoic acid of Listeria monocytogenes serotype 4b with galactose and glucose. (asm.org)
  • In addition, we have cloned the MSP gene and expressed functional protein in bacteria. (fsu.edu)
  • First, a full-length functional ZIKV cDNA clone was engineered as a bacterial artificial chromosome, with each reporter gene under the cap-independent translational control of a cardiovirus-derived internal ribosome entry site inserted downstream of the single open reading frame of the viral genome. (mdpi.com)
  • Prenatal Fanconi anemia diagnosis can be accomplished by demonstration of chromosome breaks in cells obtained in utero from chorionic villus biopsy, amniocentesis, or cord blood (by cordocentesis) or by identification of Fanconi anemia gene mutations in DNA extracted from fetal cells. (medscape.com)
  • correction of chromosome breakage or of impaired growth by a specific vector indicates that the cells have a mutation in that gene. (medscape.com)
  • 1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)
  • 2000). In *Correspondence to: Perrine Barraud, Department of Veterinary Medi- contrast, several cell surface markers have been used to cine, Neurosciences, Madingley Road, Cambridge CB3 OES, United enrich for NSCs in the rodent CNS. (lu.se)
  • In this course, we will cover subject matter in biochemistry, organic chemistry and structural biology. (columbia.edu)
  • The course is intended to provide a foundation of structural biology, bio-organic chemistry and biochemistry and to expose students to some emerging areas of research. (columbia.edu)
  • This four and a half-credit course will present an introduction to the Biophysical Chemistry and Structural Biology of proteins and nucleic acids. (columbia.edu)
  • The Emerging Cell Biology of Thyroid Stem Cells. (genescells.ru)
  • 3 Epithelial Cell Biology in ENT Research Group (EpiCENTR), Developmental Biology and Cancer, Great Ormond Street UCL Institute of Child Health, University College London , London, U.K. (biorxiv.org)
  • Likelihood-based approaches to errors have proven to be powerful and adaptable in experimental structural biology, finding applications in both crystallography and cryo-EM. (bvsalud.org)
  • 1999. Localized depolymerization of the major sperm protein cytoskeleton correlates with forward movement of the cell body in the amoeboid movement of nematode sperm. (fsu.edu)
  • A cell-based functional assay system measuring hypertrophic cell growth of neonatal rat ventricle cardiomyocytes (NRVMs) following phenylephrine treatment was applied, and changes in phosphorylation of individual differentially phosphorylated sites were induced by incorporation of phosphorylation competition peptides conjugated with cell-penetrating peptides. (molcells.org)
  • Forbes KJ, Hagen M, Glatt H, Hume R, Coughtrie MW: Human fetal adrenal hydroxysteroid sulphotransferase: cDNA cloning, stable expression in V79 cells and functional characterisation of the expressed enzyme. (t3db.ca)
  • Adoptive cell therapy using engineered T-cell receptors (TCRs) targeting cancer-testis antigens, such as Melanoma-associated antigen 3 (MAGE-A3), is a potential approach for the treatment of NSCLC. (thno.org)
  • However, systematic analysis of T cell immune responses to MAGE-A3 antigen and corresponding antigen-specific TCR is still lacking. (thno.org)
  • In this study, we comprehensively screened HLA-A2 restricted MAGE-A3 tumor epitopes and characterized the corresponding TCRs using in vitro artificial antigen presentation cells (APC) system, single-cell transcriptome and TCR V(D)J sequencing, and machine-learning. (thno.org)
  • These glycoproteins include the CD98 heavy chain protein of Mus musculus (gbU25708) and the orthologous 4F2 cell surface antigen heavy chain of Homo sapiens (spP08195). (tcdb.org)
  • The CD44 antigen is known to display extensive size heterogeneity when compared between different tissue sources although the structural basis for this variation is not yet clear. (ox.ac.uk)
  • Recently, two further isotypes in addition to the basic hemopoietic form of the CD44 antigen have been cloned and sequenced and these have been found to contain all or part of a 200-400-base pair insert within the extracellular domain, suggesting that the characteristic heterogeneity in the molecule may be generated by a mechanism of alternative splicing. (ox.ac.uk)
  • The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
  • We previously established a direct single-cell analysis to simultaneously identify and quantify in vivo CMV-CTL clones after allo-HCT 9 , 10 . (nature.com)
  • We are also interested in how the cell controls MSP polymerization in vivo because the localized formation of filaments along the leading edge of the pseudopod appears to be the key event in locomotion. (fsu.edu)
  • While much is known about the ErbB receptor binding characteristics of BTC and its effect on a variety of cultured cells under different conditions, the challenge that lies ahead is to determine the role of BTC in vivo. (embl.de)
  • The data concerning genetic and protein markers of thyroid stem cells, as well as markers of their thyroid differentiation, are systematized. (genescells.ru)
  • Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors. (genescells.ru)
  • DNMT3A is a critical regulator of hematopoietic stem cell (HSC) differentiation and somatic DNMT3A mutations are frequent in hematologic malignancies and clonal hematopoiesis. (haematologica.org)
  • Little is known about the developmental origin, determination and differentiation of different pineal immunoreactive cells in the avian group, and an experimental establishment is then required to explain the differentiation of cell types (i.e. photosensory, neural and secretory types). (bioone.org)
  • The results of the present study, a combined analysis of morphometry and RIA, open a new line for research into the pineal development and cell differentiation. (bioone.org)
  • Expression is particularly high in the pancreas where it is thought to play a role in the differentiation of pancreatic beta cells. (embl.de)
  • Sequential rounds of division and differentiation give rise to an enormous amplification of cell numbers, necessary for the production of mature blood cells. (justia.com)
  • This process of division and differentiation is subject to regulation at many levels to control cell production. (justia.com)
  • Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)
  • 1998. Structural basis for amoeboid motility in nematode sperm. (fsu.edu)
  • They thought that inefficient removal of peroxide might be responsible for the high rates of sister chromatid exchange and chromosomal damage in Bloom syndrome cells. (medscape.com)
  • Whittaker, G. R. Host cell entry of Center East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein. (viralstake.com)
  • Structural affect on SARS-CoV-2 spike protein by D614G substitution. (viralstake.com)
  • CD31 is a 130 kDa integral membrane protein, a member of the immunoglobulin superfamily, that mediates cell-to-cell adhesion. (bdbiosciences.com)
  • Roitsch T, Lehle L. Structural requirement for protein glycosylation. (rusmedserv.com)
  • Protein Phosphatase 2A (PP2A) is a widely expressed family of protein phosphatases made of a core dimer, composed of a catalytic (C) subunit and a structural (A) subunit, in association with a third variable regulatory (B) subunit. (ac.be)
  • Confocal microscopy was used in an attempt to localize cystatin C-GFP protein expression in cells. (biomedcentral.com)
  • This pattern of expression was not anticipated since cystatin C is primarily a secreted protein that should have produced a vesicular localization of fluorescence within the cell. (biomedcentral.com)
  • The cell-free infection systems were based on cell-free protein expression systems: two commercial systems and one custom-made system. (fortunejournals.com)
  • The review presents literature data on embryogenesis, physiological and reparative thyroid gland (TG) regeneration in the postnatal period in terms of substantiating the presence of stem/progenitor cells in its tissue. (genescells.ru)
  • Unresolved problems and perspectives of the use of thyroid stem/progenitor cells in tissue engineering are discussed. (genescells.ru)
  • Fierabracci A. Identifying thyroid stem/progenitor cells: advances and limitations. (genescells.ru)
  • Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. (justia.com)
  • When stimulated to divide, they give rise to more committed, differentiated daughter cells with less proliferative potential, called "early progenitor" cells. (justia.com)
  • Current treatments to manage the problems that result from prolonged bone marrow suppression include the reinfusion of a patient's own previously harvested hematopoietic stem and progenitor cells. (justia.com)
  • In such procedures, patients undergo successive treatments with cell mobilization agents to cause mobilization of hematopoietic progenitor cells from the bone marrow to the peripheral circulation for harvesting. (justia.com)
  • Couldrey C., Lee R.S., DNA methylation patterns in tissues from mid-gestation bovine foetuses produced by somatic cell nuclear transfer show subtle abnormalities in nuclear reprogramming. (biologie-journal.org)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Phorbol esters (PE) are analogues of DAG and potent tumour promoters that cause a variety of physiological changes when administered to both cells and tissues. (embl-heidelberg.de)
  • Apoptosis of tumor cells was measured in lung tissues following melanoma cell injection. (biomedcentral.com)
  • Invasion of host tissues is a hallmark feature of metastasis and requires alterations in tumor cell adhesion, cell migration, and proteolytic degradation of tissue matrices [ 1 , 2 ]. (biomedcentral.com)
  • Growth of metastases in tissues also requires invasion of host endothelial cells into tumor masses to support further the metabolic needs of tumor growth [ 3 ]. (biomedcentral.com)
  • In this study we show over-expression of cystatin C in melanoma cells is associated with reduced metastasis and increased apoptosis in lung tissues. (biomedcentral.com)
  • genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
  • Subcutaneous tumor growth and tumor cell metastasis from primary tumors were also analyzed. (biomedcentral.com)
  • We suggest that a mechanism of alternative exon splicing generates much of the observed structural heterogeneity of CD44 and that the particular set of CD44 variants expressed in a single cell may represent a precise postal code directing the final destination of migrating cells and metastatic tumors. (ox.ac.uk)
  • Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)
  • J Cell Sci (2002) 115 (12): 2581-2590. (biologists.com)
  • 2002). In humans, SSEA4 is expressed by building the nervous system but also for their prospec- nonneural cells such as the erythrocytes (Kannagi et al. (lu.se)
  • BML mutations thus result in defects in DNA repair and genomic instability in the somatic cells, predisposing the patients to cancer development. (medscape.com)
  • The overall result of the genomic instability in the proliferating cells is a high risk of malignancy, reduced fertility or infertility, B- and T-cell immunodeficiencies, and cutaneous manifestations, including photosensitivity, poikiloderma, and telangiectatic erythema. (medscape.com)
  • that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)
  • Giraldo A.M., Hylan D.A., Ballard C.B., Purpera M.N., Vaught T.D., Lynn J.W., Godke R.A., Bondioli K.R., Effect of epigenetic modifications of donor somatic cells on the subsequent chromatin remodeling of cloned bovine embryos. (biologie-journal.org)
  • We identified the HLA-A2 restricted T cell epitopes from MAGE-A3 that could effectively induce the activation and cytotoxicity of CD8+ T cells using artificial APC in vitro . (thno.org)
  • To analyze the contribution of cysteine proteases to metastasis we have over-expressed in B16 melanoma cells the natural cysteine protease inhibitor, cystatin C. We measured in vitro invasion of cystatin over-expression clones with Boyden chamber type assays. (biomedcentral.com)
  • Results show the in vitro invasion of cystatin C over-expressing cells was dramatically inhibited. (biomedcentral.com)
  • The present in vitro study suggests that the avian pineal organ is made up of multiple types of cells with different immunore-activity at the ontogenic state (from embryonic day 9 to day 14), before it acquires the final photoendocrinal nature of the mature state. (bioone.org)
  • In insect, Drosophila melanogaster ryanodine receptor ( DmRyR ) cDNA was cloned from lava and the physical features of DmRyR single channel were characterized with in vitro overexpression system [ 16 ]. (biomedcentral.com)
  • The course includes a series of biophysical research-related topics including practical introductions to the software tools available for the visualization and modeling of biomolecular structures and the bioinformatic analysis of biomolecular sequence and structural homology. (columbia.edu)
  • CRISPR-HOT avoids extensive cloning and outperforms homology directed repair (HDR) in achieving precise integration of exogenous DNA sequences into desired loci, without the necessity to inactivate TP53 in untransformed cells, which was previously used to increase HDR-mediated knock-in. (nih.gov)
  • A skewed preference for BV7 genes and sequential "G" amino acids motif is observed in complementarity-determining region-3 of T cell receptor-β. (nature.com)
  • An individual T-cell has a specific complementarity-determining region 3 (CDR3) of T cell receptor (TCR)-α and -β, which is a result of the recombination of somatic TCR V-(D)-J genes and junction diversity. (nature.com)
  • The expression of cyclin-dependent kinase inhibitors was profoundly affected with early activation and then repression of p21 cip1/waf1 and persistent activation of both p27 kip1 and p57 kip2 , whereas genes involved in cell survival and proliferation were suppressed. (aacrjournals.org)
  • Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
  • Cheng X., Blumenthal R.M., Coordinated chromatin control: structural and functional linkage of DNA and histone methylation. (biologie-journal.org)
  • Generation of functional thyroid from embryonic stem cells. (genescells.ru)
  • Ma R., Latif R., Davies T.F. Human embryonic stem cells form functional thyroid follicles. (genescells.ru)
  • In this study, an integrated approach combining quantitative phosphoproteomics and cell-based functional screening using phosphorylation competition peptides was developed. (molcells.org)
  • Cell-based functional screening against 18 selected phosphorylation sites identified three phosphorylation sites (Ser-98, Ser-179 of Ldb3, and Ser-1146 of palladin) displaying near-complete inhibition of cardiac hypertrophic growth of NRVMs. (molcells.org)
  • Kimura S. Thyroid Regeneration: How Stem Cells Play a Role? (genescells.ru)
  • Lin R.Y. New insights into thyroid stem cells. (genescells.ru)
  • Thyroid stem cells-danger or resource? (genescells.ru)
  • Ma R., Latif R., Davies T.F. Thyroid follicle formation and thyroglobulin expression in multipotent endodermal stem cells. (genescells.ru)
  • Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. (justia.com)
  • In particular, embodiments of the method involve inhibition of both Rac1 and Rac2 GTPases to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject. (justia.com)
  • Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. (justia.com)
  • The various mature blood cell types are all ultimately derived from a single class of progenitor cell known as hematopoietic stem cells. (justia.com)
  • True stem cells are both pluripotent-that is they can give rise to all cell types-and capable of self-renewal. (justia.com)
  • Stem cells represent a very small percentage of bone marrow cells, and are normally quiescent. (justia.com)
  • Other cell types derived from hematopoietic stem cells include platelets and erythrocytes. (justia.com)
  • The use of high-dosage chemotherapy or radiotherapy for bone marrow ablation requires subsequent incorporation of hematopoietic stem cells into the patient, in which case prior harvesting of such cells is required. (justia.com)
  • The success of treatment crucially depends on the mobilization of the bone marrow stem cells, the subsequent return of which permits the patient to achieve reconstitution of a functioning hematopoietic system. (justia.com)
  • In many cases, successfully mobilization is not effected in the patient and inadequate numbers of hematopoietic stem cells are harvested from these patients using current methods. (justia.com)
  • Kopecny V., Fléchon J.E., Camous S., Fulka J. Jr., Nucleologenesis , and the onset of transcription in the eight-cell bovine embryo: fine-structural autoradiographic study. (biologie-journal.org)
  • Complementation of the mutants with the cloned gtcA in trans restored galactose and glucose on teichoic acid to wild-type levels. (asm.org)
  • Avian influenza polymerase undergoes host adaptation in order to efficiently replicate in human cells. (nature.com)
  • In particular, mutation of PB2 residue 627 from E to K rescues polymerase activity in mammalian cells. (nature.com)
  • However, for these avian (av) viruses to efficiently replicate in mammalian cells, host adaptation of the viral polymerase is necessary. (nature.com)
  • Human ANP32A ( h ANP32A) lacks an insertion of 33 disordered residues compared to av ANP32A, restricting av H5N1 polymerase activity in mammalian cells. (nature.com)
  • wherein the online der eisenbau grundlagen der konstruktion feste brücken polysaccharides are assumed in facile steroids, the generic article polymerase will be member modelling from lac to Mammalian monocots, and this will be Additional restriction and net in the streptavidin of different cells. (naturheilpraxis-gisbert-fussek.de)
  • We have obtained further evidence for alternative splicing, and we report here the cloning and sequencing of six different CD44 sequence variants from a variety of cell lines using a combination of expression cloning and the polymerase chain reaction. (ox.ac.uk)
  • A double reporter-in which the mitotic spindle was labelled by endogenously tagged tubulin and the cell membrane by endogenously tagged E-cadherin-uncovered modes of human hepatocyte division. (nih.gov)
  • Liposome-mediated transfection of intact viral particles reveals that plasma membrane penetration determines permissivity of tissue culture cells to rotavirus. (microbiologyresearch.org)
  • Although these cells have an unconventional cytoskeleton, they display all of the characteristic features (localized protrusion, membrane ruffling, cytoskeletal flow) exhibited by actin-rich amoeboid cells. (fsu.edu)
  • BTC is proteolytically processed from a larger membrane-anchored precursor and is a potent mitogen for a wide variety of cell types. (embl.de)
  • Virus particles have a nucleic acid genome and may also carry a few viral proteins, which are enclosed in a capsid of viral proteins or an envelope comprised of a small part of the host cell membrane. (fortunejournals.com)
  • In spite of this similar organization, the SARS-CoV RNA cells showed the virions within cell vesicles and around the sequence is only distantly related to that of previously cell membrane. (cdc.gov)
  • We studied the course of infection by analysing the production of viral RNA, proteins and phage particles produced in the cell-free reactions. (fortunejournals.com)
  • Specifically, the viral RNA was replicated, the viral proteins were translated, and infectious phage particles were produced in the cell-free infection systems. (fortunejournals.com)
  • The human CD44 cell-surface glycoprotein participates in a wide variety of cell-cell interactions including lymphocyte homing and tumor metastasis. (ox.ac.uk)
  • Transcription factors interfering with dedifferentiation induce cell type-specific transcriptional profiles. (dna-chip.co.jp)
  • Helminth infections associated with multiple sclerosis induce regulatory B cells. (uni-bielefeld.de)
  • Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
  • CRISPR-HOT was used to fluorescently tag and visualize subcellular structural molecules and to generate reporter lines for rare intestinal cell types. (nih.gov)
  • Distinct pathways of cell migration and antiapoptotic response to epithelial injury: structure-function analysis of human intestinal trefoil factor. (embl.de)
  • Tortorici, M. A. & Veesler, D. Structural insights into coronavirus entry. (viralstake.com)
  • Cloning and sequence analysis of the human salivary peroxidase-encoding cDNA. (rusmedserv.com)
  • Derwahl M, Seto P, Rapoport B. Complete nucleotide sequence of the cDNA for thyroid peroxidase in FRTL5 rat thyroid cells. (rusmedserv.com)
  • The expression of cystatin C-GFP fusion was observed in B16F10 melanoma cells following transient transfection of plasmid construct DNA. (biomedcentral.com)
  • A cytoplasmic expression was noted for GFP alone and cystatin C-GFP fusion when transiently expressed in B16 melanoma cells (Figure 1 ). (biomedcentral.com)
  • Small organic molecules function in energy production and creating building blocks for the components of cells and can also be used to perturb the functions of proteins directly. (columbia.edu)
  • These links are used in cell motility as the actin cytoskeleton generates force pulling the integrin and attached matrix molecules towards the cell center. (biologists.com)
  • Structural and purposeful affect by SARS-CoV-2 Omicron spike mutations. (viralstake.com)
  • Amoeboid cell motility plays a vital role in physiological and pathological processes ranging from embryonic development and immunological defense to tumor metastasis. (fsu.edu)
  • We have isolated a SARS-associ- the complete genome of SARS-CoV has shown an RNA ated CoV (SARS-CoV) strain by injecting Vero cells with a molecule of about 29,750 bases in length, with a genome sputum specimen from an Italian patient affected by a organization similar to that of other coronaviruses (9-11). (cdc.gov)
  • Cytomegalovirus reactivation is still a critical concern following allogeneic hematopoietic cell transplantation, and cellular immune reconstitution of cytomegalovirus-specific cytotoxic T-cells is necessary for the long-term control of cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation. (nature.com)
  • These methods and results can help us to better understand immune reconstitution following hematopoietic cell transplantation, leading to future studies on the clinical application of adoptive T-cell therapies. (nature.com)
  • However, cellular immune reconstitution of CMV-specific cytotoxic T-cells (CMV-CTL) is generally considered to be necessary for the long-term control of CMV reactivation after allo-HCT. (nature.com)
  • The majority of cancer cells rely on reactivation of the enzyme telomerase or activation of the Alternative Lengthening of Telomeres pathway (ALT) to promote telomere elongation. (oncotarget.com)
  • Silencing of the EBF3 locus was observed in brain, colorectal, breast, liver, and bone tumor cell lines and its reactivation was achieved on treatment with 5-aza-2′-deoxycytidine and trichostatin A in a significant portion of these tumor cells. (aacrjournals.org)
  • Home online der eisenbau grundlagen der konstruktion feste donor with found access II procollagen has a detection in clone pCD414, as known by cancer using, multivariate with genome of N- and C-propeptides. (naturheilpraxis-gisbert-fussek.de)
  • 4 While proteins can be phosphorylated on nine amino acids, serine, threonine and tyrosine phosphorylation are by far the most predominant in eukaryotic cells. (ac.be)
  • Not only do these unique cells lack the microtubule-based axoneme associated with the swimming movement of most sperm, but they also are devoid of actin and myosin, the proteins generally considered to be the key components of amoeboid movement. (fsu.edu)
  • Comer KA, Falany JL, Falany CN: Cloning and expression of human liver dehydroepiandrosterone sulphotransferase. (t3db.ca)
  • Cell population kinetics in dog and human adult thyroid. (genescells.ru)
  • 2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
  • CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
  • The dynamic remodeling of actin filaments (F-actin) concentrated at the cell periphery is responsible for cell translocation, for cell shape changes, and for cellular resistance to potentially disruptive mechanical stresses. (rupress.org)
  • A key feature of metastatic cancer cells is their invasive ability. (biomedcentral.com)
  • After being dispersed through vascular spaces, metastatic tumor cells lodge in distant capillaries. (biomedcentral.com)
  • C1 domains are compact alpha/beta structural units of about 50 amino acids which tightly bind two zinc ions. (embl-heidelberg.de)
  • Importantly, T cells artificially expressing the MAGE-A3-Mp4 specific TCRs exhibited strong MAGE-A3+ tumor cell recognition and killing effect. (thno.org)
  • Increased tumor cell apoptosis was found to be an important factor and may be related to the reduced tumor burden noted in this system of melanoma metastasis. (biomedcentral.com)
  • Although cardiac hypertrophy is initiated by various receptors at cell membranes sensing biomechanical signals and hormones, it is generally mediated by cellular signaling cascades. (molcells.org)
  • Integrins are transmembrane receptors that mediate cell adhesion by forming links between the extracellular matrix and cytoskeleton. (biologists.com)
  • Coordinated localisation of mucins and trefoil peptides in the ulcer associated cell lineage and the gastrointestinal mucosa. (embl.de)
  • The ulcer associated cell lineage (UACL) occurs at sites of chronic ulceration in Crohn's disease, expresses all three trefoil peptides, and is implicated in mucosal restitution. (embl.de)
  • such online der with an stress residual to the model is that shorter attention lines chromosome in the plot of linkage but However domains, while longer downloads interference in accuracy of the mixed-effects by Lys-C. To ask the fitting online der of the recombinant direction, we were the expression amplification coding conditional cell( integration) roughness. (naturheilpraxis-gisbert-fussek.de)
  • Chromosome breakage is usually examined in short-term cultures of peripheral blood T-cell mitogen-stimulated lymphocytes in the presence of DNA cross-linkers, such as DEB or MMC. (medscape.com)
  • We show here that expression of EBF3 resulted in cell cycle arrest and apoptosis. (aacrjournals.org)
  • Lignin, a polymer of aromatic subunits derived from phenylalanine serves as a matrix around the polysaccharide components of some plant cell walls, providing rigidity and comprehensive strength (Whetten and Sederoff, 1995). (scialert.net)
  • Previous studies have shown that small beads coated with FN7-10, a four-domain cell adhesion fragment of fibronectin, bind to cell surfaces and translocate rearward. (biologists.com)
  • Two-color flow cytometric analysis of CD31 expression on BALC/c mouse bone marrow cells. (bdbiosciences.com)
  • Two-color flow cytometric dot plots show the correlated expression patterns of CD31 (or Ig Isotype control staining) versus CD45R/B220 for gated events with the forward and side light-scatter characteristics of viable bone marrow cells. (bdbiosciences.com)
  • Nucleoside diphosphate kinase: role in bacterial growth, virulence, cell signalling and polysaccharide synthesis. (embl.de)
  • We show that PETases can be functionally displayed on the bacterial cell surface, enabling screening of enzyme activity on PET microparticles - both while anchored to the cell and following solubilization of the enzymes. (biomedcentral.com)
  • The results imply that, in addition to PAL, other lignin-specific enzymes and/or tissue structural changes may have more significant roles in tissue toughening of broccoli branchlets. (scialert.net)
  • Adenot P.G., Mercier Y., Renard J.P., Thompson E.M., Differential H4 acetylation of paternal, maternal chromatin precedes DNA replication, and differential transcriptional activity in pronuclei of 1-cell mouse embryos. (biologie-journal.org)
  • Coronaviruses are enveloped, positive-stranded RNA analysis of the consequences of virus replication in Vero viruses associated with enteric and respiratory diseases in cells. (cdc.gov)
  • Role of intracellular trafficking of thyroperoxidase and involvement generated at the apical surface of thyroid cells in covalent heme binding. (rusmedserv.com)
  • Bone marrow cells were stained with APC Rat Anti-Mouse CD45R/B220 antibody (Cat. (bdbiosciences.com)
  • The present invention relates generally to improved methods and pharmaceutical compositions for mobilizing hematopoietic stem and progenitor cell from bone marrow into peripheral blood by administration of at least one inhibitor of a GTPase, such as Rac1 and/or Rac2 GTPase. (justia.com)
  • These therapies decrease a patient's white blood cell counts, suppress bone marrow hematopoietic activity, and increase the patient's risk of infection and/or hemorrhage. (justia.com)
  • After harvesting, the patient is given high dose chemotherapy or radiotherapy and the bone marrow function is reconstituted by infusion of the cells harvested earlier. (justia.com)
  • 2004), the ABC trans- panded neurosphere cells and also mark subfractions porter Bcrp1/ABCG2 (Hulspas et al. (lu.se)
  • The domains in the CHR are the structural hallmarks of the hematopoietic cytokine receptor family (2). (rndsystems.com)