• In healthy individuals, nicotine improves memory impairment caused by sleep deprivation by enhancing the phosphorylation of calmodulin‑dependent protein kinase II, an essential regulator of cell proliferation and synaptic plasticity. (spandidos-publications.com)
  • Long noncoding RNAs (lncRNAs) regulate a number of physiological and pathological processes, including gene transcription and translation, chromatin modification, cell cycle progression, cell proliferation, and oncogenic and tumor-suppressive signals in cancer 6 . (researchsquare.com)
  • The high AGE diet also led to increased recruitment and proliferation of stromal cells to abnormal structures that persisted into adulthood. (biomedcentral.com)
  • During both these processes, mitosis, cell proliferation, differentiation and migration of cells have been observed in the endometrium (11). (jri.ir)
  • Effects of chloroplast DNA content on the cell proliferation and aging in Chlamydomonas reinhardtii. (bio.net)
  • Required for normal embryonic development and normal cell proliferation. (t3db.ca)
  • We hypothesized that, in CBD, failure of IL-10 to modulate the beryllium-specific, cell-mediated immune response would result in persistent, maximal cytokine production and T lymphocyte proliferation, thus contributing to the development of granulomatous lung disease. (cdc.gov)
  • bronchoalveolar lavage cells from control and CBD subjects to evaluate the beryllium salt-specific production of endogenous IL-10 and the effects of exogenous human rIL-10 (rhIL-10) on HLA expression, on the production of IL-2, IFN- , and TNF- , and on T lymphocyte proliferation. (cdc.gov)
  • We of both mitogen- and Ag-induced accessory cell-dependent T lym- phocyte proliferation. (cdc.gov)
  • CD195 mediates an intracellular signal thought to induce cell differentiation and proliferation. (biolegend.com)
  • A gain of function screen for genes that enable proliferation independently of matrix anchorage identified a cell adhesion molecule PVRL4 (poliovirus-receptor-like 4), also known as Nectin-4. (elifesciences.org)
  • Shan J, Ma JM, Wang R, Liu QL, Fan Y. Proliferation and Apoptosis of Peripheral Blood Mononuclear Cells in Patients with Oral Lichen Planus. (medscape.com)
  • We sought to extend the receptor-desensitization paradigm for use with a cultured cell system, in which an intracellular calcium signal rather than a contractile response might be used as an index of receptor activation. (aspetjournals.org)
  • Background: Receptor for hyaluronic acid mediated motility (RHAMM) has intracellular and extracellular functions. (jri.ir)
  • Receptor for Hyaluronic Acid Mediated Motility (RHAMM, CD168) is a Hyaluronic acid (HA) receptor with many intracellular and extracellular functions (1). (jri.ir)
  • In recent years, the search for intracellular signaling integrator downstream of receptor tyrosine kinases provided valuable novel substrates. (springer.com)
  • KDN21 contains δ and κ opioid receptor antagonist pharmacophores that are connected through a 21-atom spacer ( Fig. 1 ). (aspetjournals.org)
  • 2002). In humans, SSEA4 is expressed by building the nervous system but also for their prospec- nonneural cells such as the erythrocytes (Kannagi et al. (lu.se)
  • These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. (chemeurope.com)
  • Expression cloning of an activin receptor, a predicted transmembrane serine kinase. (chemeurope.com)
  • Structurally, all known receptor PTPases, are made up of a variable length extracellular domain, followed by a transmembrane region and a C-terminal catalytic cytoplasmic domain. (embl.de)
  • CD195, also known as CCR5, is a 45 kD G protein-coupled seven transmembrane CC-chemokine receptor. (biolegend.com)
  • Mammary epithelial cell migration and invasion in response to AGE-mediated fibroblast activation was determined in two-compartment co-culture models. (biomedcentral.com)
  • Ex vivo fibroblasts from mice fed dietary-AGEs retain an activated phenotype and promoted epithelial migration and invasion of non-transformed immortalized and tumor-derived mammary epithelial cells. (biomedcentral.com)
  • Mechanistically, we found that the receptor for AGE (RAGE) is required for AGE-mediated increases in epithelial cell migration and invasion. (biomedcentral.com)
  • Further, both epithelial and stromal cell populations were impacted by the high AGE diet in the mammary gland. (biomedcentral.com)
  • Distinct pathways of cell migration and antiapoptotic response to epithelial injury: structure-function analysis of human intestinal trefoil factor. (embl.de)
  • 1996). "Inhibitory effects of activin on the growth and morpholgenesis of primary and transformed mammary epithelial cells. (chemeurope.com)
  • Current data suggest that oral lichen planus (OLP) is a T-cell-mediated autoimmune disease in which autocytotoxic CD8 + T cells trigger the apoptosis of oral epithelial cells. (medscape.com)
  • Epithelial tissue is one of the four major types of tissue found in animals, and is the only type of tissue that is able to form and maintain layers of cells that are just one cell thick. (elifesciences.org)
  • This mechanism preserves the single-cell layer pattern throughout the body and prevents epithelial cells from growing in inappropriate locations. (elifesciences.org)
  • It is estimated that up to 90% of cancers in humans originate in epithelial tissue, and the cells within such tumors are known to survive and divide even when they are no longer attached to the extracellular matrix. (elifesciences.org)
  • explored which genes enable epithelial cells from the human mammary gland to grow without being attached to the extracellular matrix. (elifesciences.org)
  • Normally, the PVRL4 gene is not active in breast epithelial cells, but its activity is detected in many breast, lung, and ovarian tumors. (elifesciences.org)
  • Here, we report the pro-tumorigenic properties of the crosstalk between intestinal tuft cells and type 2 innate lymphoid cells (ILC2) that is evolutionarily optimized for epithelial remodeling in response to helminth infection. (bvsalud.org)
  • We demonstrate that tuft cell-derived interleukin 25 (IL25) drives ILC2 activation, inducing the release of IL13 and promoting epithelial tuft cell hyperplasia. (bvsalud.org)
  • Among these features are the peculiar tropism of the virus for Vero cells (a continuous cell line established from monkey kidney epithelial cells), its capacity for growth at 37°C (while other respiratory coronaviruses grow at lower temperatures), and its ability to infect lower respiratory tract tissues ( 13 ). (cdc.gov)
  • Complete cDNA cloning in human and partial cloning in Chinese hamster ovary cells. (nih.gov)
  • The cDNA probes will be used to study the regulation of secretin mRNA levels by different signal transduction pathways in a secretin producing cell line. (grantome.com)
  • Cloning of the human activin receptor cDNA reveals high evolutionary conservation. (chemeurope.com)
  • Elwood PC: Molecular cloning and characterization of the human folate-binding protein cDNA from placenta and malignant tissue culture (KB) cells. (t3db.ca)
  • Leukotriene B4 receptor 1 is a protein that in humans is encoded by the LTB4R gene. (wikipedia.org)
  • Endothelial protein C receptor (EPCR) also known as activated protein C receptor (APC receptor) is a protein that in humans is encoded by the PROCR gene . (wikidoc.org)
  • The protein encoded by this gene is a receptor for protein C that enhances its activation. (wikidoc.org)
  • Via positional cloning, we show that mutations in a zebrafish LTCC encoding gene, cav1.3a , underlie the auditory-vestibular defects of gemini ( gem ) circler mutants. (jneurosci.org)
  • The FA2 gene of Chlamydomonas encodes a NIMA family kinase with roles in cell cycle progression and microtubule severing during deflagellation. (bio.net)
  • Activin A receptor, type IIA , also known as ACVR2A , is a human gene. (chemeurope.com)
  • This gene encodes activin A type II receptor. (chemeurope.com)
  • a b Entrez Gene: ACVR2A activin A receptor, type IIA. (chemeurope.com)
  • 1994). "Expression of the type II activin receptor gene in the human placenta. (chemeurope.com)
  • CXCL10 was originally identified as an IFN-gamma -inducible gene in monocytes, fibroblasts and endothelial cells. (rndsystems.com)
  • Cells were checked to ensure the absence of mycoplasma contamination and genotyped for their species of origin by sequencing of the mitochondrial cytochrome c subunit oxidase I gene ( 12 ). (cdc.gov)
  • Gene-environment interactions, sunlight and vitamin D, and T lymphocytes as autoimmune disease initiators and vitamin D targets are discussed to explain the rationale for reviewing vitamin D mechanisms in T cells. (frontiersin.org)
  • Elwood PC, Nachmanoff K, Saikawa Y, Page ST, Pacheco P, Roberts S, Chung KN: The divergent 5' termini of the alpha human folate receptor (hFR) mRNAs originate from two tissue-specific promoters and alternative splicing: characterization of the alpha hFR gene structure. (t3db.ca)
  • They found that the gene that codes for a protein called poliovirus receptor-like 4 (PVRL4) allows attachment-free cell growth and also makes cells cluster together once detached from the matrix. (elifesciences.org)
  • In gastric cancer patients, tuft cell and ILC2 gene signatures predict worsening survival in intestinal-type gastric cancer where ~40% of the corresponding cancers show enriched co-existence of tuft cells and ILC2s. (bvsalud.org)
  • The results of studies with selective agonists and antagonists in vivo are consistent with cooperativity between δ and κ receptors, and it has been proposed that the putative δ 1 and κ 2 opioid receptor subtypes are actually phenotypes ( Portoghese and Lunzer, 2003 ). (aspetjournals.org)
  • We found that at blastula stages, FGFA and a novel putative FGF receptor are expressed in a pattern that prefigures morphogenesis of the skeletogenic mesoderm and that suggests that FGFA is one of the elusive signals that guide migration of primary mesenchyme cells (PMCs). (biologists.com)
  • BTC binds and activates ErbB-1 and ErbB-4 homodimers and is further characterised by its unique ability to activate all possible heterodimeric ErbB receptors. (embl.de)
  • Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. (t3db.ca)
  • It binds to MIP-1α, MIP-1β, and RANTES and is expressed on a subset of T cells and monocytes. (biolegend.com)
  • The G protein-coupled receptor, RDC1, belongs to a subgroup of chemokine receptors and has been designated CXCR7. (rndsystems.com)
  • Does staining at room temperature or even at 37°C help for checking chemokine receptors expression? (biolegend.com)
  • Due to continuous recycling of many chemokine receptors, it may be worthwhile to consider staining at room temperature or at 37°C if the staining at lower temperature (which can potentially reduce receptor turnover) is not optimal. (biolegend.com)
  • Binding of these ligands to RAGE does not accelerate clearance or degradation but rather begins a sustained period of cellular activation mediated by receptor-dependent signaling. (jci.org)
  • Other unusual features of the receptor include its ability to engage classes of molecules, rather than individual ligands, and its enhanced surface expression in environments rich in RAGE ligands. (jci.org)
  • Taken together, these features of RAGE allow the receptor to propagate cellular dysfunction in a number of pathophysiologically relevant situations, most often dictated by the formation and persistence of ligands in the tissues. (jci.org)
  • Zaveri N, Jiang F, Olsen C, Polgar W and Toll L: Novel α3β4 nicotinic acetylcholine receptor-selective ligands. (spandidos-publications.com)
  • Furthermore, we reasoned that, provided receptor cross-desensitization did not occur, it would be advantageous to assess PAR-targeted ligands in a cell that expressed both receptors. (aspetjournals.org)
  • This review highlights some of the major findings pertinent to the epidermal growth factor (EGF) receptor and its ligands, particularly the major gut ligand transforming growth factor-alpha, as well as the trefoil peptides. (embl.de)
  • Betacellulin (BTC) belongs to the epidermal growth factor (EGF) family of peptide ligands that are characterised by a six-cysteine consensus motif that forms three intra-molecular disulfide bonds crucial for binding the ErbB receptor family. (embl.de)
  • and type II receptors are required for binding ligands and for expression of type I receptors. (chemeurope.com)
  • 1996). "Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors. (chemeurope.com)
  • 1996). "Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5. (chemeurope.com)
  • 1996) J. Biol. (rndsystems.com)
  • Molecular cloning and binding properties of the human type II activin receptor. (chemeurope.com)
  • Finally, unanswered questions relating to vitamin D mechanisms in CD4 + T cells are highlighted to promote further research that may lead to a deeper understanding of autoimmune disease molecular etiology. (frontiersin.org)
  • The earliest biochemical evidence on the existence of cell-free soluble LH receptor was the purification of an hCG-binding protein, relative molecular mass of 65K (M r , 65K) from porcine follicular fluid and was based on gel filtration followed by affinity chromatography [ 9 ]. (biomedcentral.com)
  • 1993). "Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors. (chemeurope.com)
  • Here, we show that plexin-B family members stably associate with the receptor tyrosine kinase ErbB-2. (rupress.org)
  • Mammalian Cdc25 phosphatase is responsible for the dephosphorylation of Cdc2 and other cyclin-dependent kinases at Thr14 and Tyr15, thus activating the kinase and allowing cell cycle progression. (embl.de)
  • The protein is also involved in Plasmodium falciparum malaria as subtypes of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family use EPCR of the host as a receptor. (wikidoc.org)
  • BTC is proteolytically processed from a larger membrane-anchored precursor and is a potent mitogen for a wide variety of cell types. (embl.de)
  • Here, we review current knowledge how proteases act on platelet receptors and the platelet membrane surface. (frontiersin.org)
  • The relatively narrow intercellular space of the primordial follicle allows ferritin and possibly other molecules of similar size to cross, whereas in the late stages of rapid follicular growth, the shape of granulosa cells must accommodate the increasing flow of egg yolk precursors that accumulate at the surface of the plasma membrane of the follicle [ 7 ]. (biomedcentral.com)
  • Therefore, how a complex LHCGR protein, embedded within the membrane lipid bilayer, could be secreted as soluble receptor remained unexplained. (biomedcentral.com)
  • Ultrastructural analysis of infected Vero cells showed the virions within cell vesicles and around the cell membrane. (cdc.gov)
  • The flow cytometric dot plots show the correlated expression patterns of CD19 (Upper Panels) or CD14 (Lower Panels) versus Leptin Receptor (CD295) [or Ig Isotype control staining] for gated events with the forward and side light-scatter characteristics of viable mononuclear leucocytes. (bdbiosciences.com)
  • For example, increased expression of LINC00958 attributes to cell metastasis in gastric cancer 7 . (researchsquare.com)
  • Three-color image analysis of F4/80 expression by cells in C57BL/6 mouse spleen. (bdbiosciences.com)
  • Expression is particularly high in the pancreas where it is thought to play a role in the differentiation of pancreatic beta cells. (embl.de)
  • Due to the conflicting reports published, use of monoclonal MAB4227 may result in an underestimation of CXCR7 expression on certain cell types. (rndsystems.com)
  • Reports of mRNA levels and/or protein expression (as assessed using anti‑CXCR7, clone 9C4) (1, 2) indicate that CXCR7 occurs on a wide variety of tissues and cells including monocytes, B cells, T cells and mature dendritic cells. (rndsystems.com)
  • In contrast, based on ligand binding analysis and receptor level (as assessed using anti‑CXCR7, clone 11G8), surface expression of CXCR7 was reported to be restricted to tumor cells, activated endothelial cells, fetal liver cells, and few other cell types (3). (rndsystems.com)
  • Moreover, the lack of a secreted form of the receptor was overcome by co-expression of hCG with the extra-cellular domain of porcine LH receptor leading to the secretion of a mixture of free as well as hCG-receptor complex [ 13 ]. (biomedcentral.com)
  • Additionally, the truncated Lhcgr, misrouted the full-length Lhcgr in ER, thereby decreasing the cell surface expression of the mature functional receptor. (biomedcentral.com)
  • instead, a specific intra-cellular role of truncated receptor in regulating the cell surface expression of a full-length ligand-binding Lhcgr has been proposed [ 15 ]. (biomedcentral.com)
  • Our data demonstrate that beryllium-stimulated bronchoalveolar lavage cells produce IL-10, and the neutralization of endogenous IL-10 does not increase significantly cytokine production, HLA expression, or T lymphocyte pro- liferation. (cdc.gov)
  • Type I and II receptor subunit (IL-2Rγ, IL-4Rα and IL-13Rα1) and M2 marker (MRC-1, CCL18, CCL22) expression was assessed via RT-qPCR in IL-4- and IL-13-treated human primary macrophages. (bvsalud.org)
  • Type I IL-4 receptor expression was increased on M1-like macrophages but did not lead to a differing ability of these cytokines to modulate M1-like macrophage superoxide production. (bvsalud.org)
  • Younes F, Quartey EL, Kiguwa S, Partridge M. Expression of TNF and the 55-kDa TNF receptor in epidermis, oral mucosa, lichen planus and squamous cell carcinoma. (medscape.com)
  • 2001). "Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. (wikidoc.org)
  • reported that anti-RHAMM antibodies block the migration of endothelial cells, which is an important key to the process of tissue injury and angiogenesis (3). (jri.ir)
  • Broide RS, Winzer-Serhan UH, Chen Y and Leslie FM: Distribution of alpha7 nicotinic acetylcholine receptor subunit mRNA in the developing mouse. (spandidos-publications.com)
  • Thus far, the results indicate that RANKL-mediated EMT in 4T1 and NMuMG cells occurs via activation of the NF-κB p65 subunit. (pdgfreceptor.com)
  • Therefore, we treated 4T1 cells with DMF, a NF-κB inhibitor, in order to determine whether suppression of the NF-κB p65 subunit would LBH589 mouse result in the inhibition of RANKL-mediated EMT. (pdgfreceptor.com)
  • The abilities of the PAR 1 -targeted agents to desensitize or block PAR 1 in the HEK cell assay were compared with their activities in a human platelet aggregation assay. (aspetjournals.org)
  • An important way of regulation is provided by proteolytic cleavage of several of these receptors, leading to either a gain or a loss of platelet function. (frontiersin.org)
  • The flow-dependent adhesion of platelets to those and other extracellular matrix components is stabilized by a panel of integrins, including integrin α 2 β 1 , α IIb β 3 , and α 6 β 1 (adhesive platelet population), while the initial activation of platelets is achieved by signaling via the collagen/laminin receptor, glycoprotein VI (GPVI). (frontiersin.org)
  • Although these platelet activation processes are relatively well-studied as a function of the platelet environment, only since recently it is becoming clear that a multitude of proteases present in plasma or produced by platelets themselves are important for the distinct properties of platelet populations, often by cleaving specific receptors. (frontiersin.org)
  • Leukocyte depletion of transfused blood products may prevent alloimmunization to platelets and should be used in patients expected to need platelet transfusions during multiple courses of chemotherapy or for candidates for hematopoietic cell transplants. (msdmanuals.com)
  • Cloning and characterization. (grantome.com)
  • Cloning and characterization of an active fragment of luciferase from a luminescent marine alga, Pyrocystis lunula. (bio.net)
  • 2000). "A second leukotriene B(4) receptor, BLT2. (wikipedia.org)
  • 1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)
  • 2000). In *Correspondence to: Perrine Barraud, Department of Veterinary Medi- contrast, several cell surface markers have been used to cine, Neurosciences, Madingley Road, Cambridge CB3 OES, United enrich for NSCs in the rodent CNS. (lu.se)
  • Regarding the selectivity of KDN21 for phenotypic δ and κ opioid receptors, we investigated the effect of KDN21 on the activation of MAPKs [extracellular signal-regulated kinases 1 and 2 (ERK1/2)] by δ- or κ-selective agonists. (aspetjournals.org)
  • gem homozygous receptor mutant HCs display normal cell viability, afferent synaptogenesis, and peripheral innervation, yet exhibit strongly reduced extracellular potentials (∼50% of wild-type potentials). (jneurosci.org)
  • Some of the receptor PTPases contain fibronectin type III (FN-III) repeats, immunoglobulin-like domains, MAM domains or carbonic anhydrase-like domains in their extracellular region. (embl.de)
  • LHCGR recombinant proteins representing varying lengths of the N-terminal extracellular domain were expressed in Chinese Hamster Ovary cells in suspension culture. (biomedcentral.com)
  • During all stages of tumor progression, cancer cells are subjected to inappropriate extracellular matrix environments and must undergo adaptive changes in order to evade growth constraints associated with the loss of matrix attachment. (elifesciences.org)
  • A single-cell layer of epithelium is separated from the tissues beneath it by a supporting substance called the extracellular matrix. (elifesciences.org)
  • Moreover, cancerous cells tend to cluster together when they are detached from the extracellular matrix. (elifesciences.org)
  • Moreover, PVRL4 triggers a form of signaling between the cells called integrin β4 signaling that allows them to survive without being anchored to the extracellular matrix. (elifesciences.org)
  • Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)
  • [ 8 ] T cells in oral lichen planus contain mRNA for TNF and secrete TNF in vitro. (medscape.com)
  • The dense subepithelial mononuclear infiltrate in oral lichen planus is composed of T cells and macrophages, and there are increased numbers of intraepithelial T cells. (medscape.com)
  • Therefore, early in the formation of oral lichen planus lesions, CD8 + T cells may recognize an antigen associated with the major histocompatibility complex (MHC) class I on keratinocytes. (medscape.com)
  • The role of autoimmunity in the pathogenesis is supported by many autoimmune features of oral lichen planus, including its chronicity, onset in adults, predilection for females, association with other autoimmune diseases, occasional tissue-type associations, depressed immune-suppressor activity in patients with oral lichen planus, and the presence of autocytotoxic T-cell clones in lichen planus lesions. (medscape.com)
  • Sugerman PB, Satterwhite K, Bigby M. Autocytotoxic T-cell clones in lichen planus. (medscape.com)
  • Ovarian cancer cell heparan sulfate 6-O-sulfotransferases regulate an angiogenic program induced by heparin-binding epidermal growth factor (EGF)-like growth factor/EGF receptor signaling. (nih.gov)
  • Nicotine may also activate thyroid receptor signaling pathways to improve memory impairment caused by hypothyroidism. (spandidos-publications.com)
  • To further identify the potential signaling pathways after the knockdown of LINC00958 in Ishikawa cells, we performed the KEGG and GO analyses (Figure 2). (researchsquare.com)
  • XLS 20 KB) Additional file 4: The most enrichment pathways among genes related to cell cycle, apoptosis, cell division and growth by KEGG. (cox-inhibitors.com)
  • Reaction between activated carbonyl groups on sugars and amino groups on proteins, lipids and nucleic acids results in biomolecules with altered structure, function and bioactivity that can alter biological processes, cause cell damage, or induce cell death [ 5 , 6 ]. (biomedcentral.com)
  • The replicase proteins p33 and p92 of Cymbidium ringspot virus (CymRSV) were found to support the replication of defective interfering (DI) RNA in Saccharomyces cerevisiae cells. (microbiologyresearch.org)
  • Receptor dimerization and autophosphorylation attracts proteins containing Src homology 2 (SH2) or phosphotyrosine binding (PTB) domains including adaptor proteins like FRS2 and GRB2. (springer.com)
  • In addition to plexins, various other proteins have been implicated either as receptors for semaphorins or as components of the semaphorin receptor complex ( Pasterkamp and Kolodkin, 2003 ). (rupress.org)
  • We demonstrate that recombinant LHCGR proteins which include the hormone-binding domain are secreted from transfected cells and that natural LHCGR is also secreted from human placental explants. (biomedcentral.com)
  • The bi-stable switch would enable T cells to integrate signals from pathogens, hormones, cell-cell interactions, and soluble mediators and respond in a biologically appropriate manner. (frontiersin.org)
  • 11 ] first reported the production and secretion of soluble LH receptor following transient transfection of a naturally truncated variant of the receptor in COS cells. (biomedcentral.com)
  • Histopathological analyses showed increased infiltration of dendritic cells (DC) and T cells into tumor tissues following 7 × 19 CAR-T cell therapy. (nature.com)
  • Figure 3: Infiltration of tumor tissues treated with 7 × 19 CAR-T cells by both T cells and DCs. (nature.com)
  • Concerning reproductive tissues, several reports have described RHAMM-mediated promotion of cell growth and movement, sperm motility (8), angiogenesis (3) and embryonic development (9). (jri.ir)
  • Placental hCG and pitutary LH transduce signals in target tissues through a common receptor (LHCGR). (biomedcentral.com)
  • Understanding how cancerous cells gain this ability may lead to new approaches to stopping tumor cells from dividing and colonizing tissues around the body. (elifesciences.org)
  • This behavior is particularly evident in the cells that divide aggressively to form tumors that subsequently migrate and colonize other tissues around the body. (elifesciences.org)
  • In this investigation we sought to answer the question concerning the presence of mast cells in human and rat dental pulp tissues, under normal and inflammatory conditions. (bvsalud.org)
  • Multicolor flow cytometric analysis of Leptin Receptor (CD295) on human mononuclear cells. (bdbiosciences.com)
  • The leucocytes were washed and stained with FITC Mouse Anti-Human CD14 (Cat No. 555397/557153/561712), BD Horizon™ V450 Mouse Anti-Human CD19 (Cat No. 644491) antibodies and either Alexa Fluor® 647 Mouse IgG2b, κ Isotype Control (Cat No. 557903) or Alexa Fluor® 647 Mouse Anti-Human Leptin Receptor (CD295) antibody (Cat No. 564376). (bdbiosciences.com)
  • The KEGG and GO analyses indicated 'Human T − cell leukemia virus 1 infection' and 'Hippo signaling pathway' were the main affected biological processes. (researchsquare.com)
  • Rosenberg, S.A. & Restifo, N.P. Adoptive cell transfer as personalized immunotherapy for human cancer. (nature.com)
  • High cleavage efficiency of a 2A peptide derived from porcine teschovirus-1 in human cell lines, zebrafish and mice. (nature.com)
  • We developed a calcium signaling-based assay, using cultured human embryonic kidney cells (HEK), that evaluates simultaneously, the activation/desensitization or blockade of the proteinase-activated receptors, PAR 1 and PAR 2 . (aspetjournals.org)
  • In contrast, thrombin receptor-activating peptides derived from the human PAR 1 receptor sequence (e.g. (aspetjournals.org)
  • To this end, we developed a calcium-signaling assay, employing cultured human embryonic kidney cells (HEK293) in which the action of PAR 1 and PAR 2 agonists and antagonists could be evaluated simultaneously. (aspetjournals.org)
  • showed, for the first time, that RHAMM is differentially expressed during all stages of preimplantation human embryos and human embryonic stem cells (hESC), and indicated that RHAMM knockdown results in down-regulation of several pluripotency markers in hESCs, induction of early extraembryonic lineage, loss of cell viability, and changes in hESC cycle (2). (jri.ir)
  • The human brain cholecystokinin-B/gastrin receptor. (grantome.com)
  • The mouse homologue of human CXCL10, CRG-2, has been cloned and shown to share approximately 67% amino acid sequence identity with human CXCL10. (rndsystems.com)
  • Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3 + CD4 + T-regulatory cell and CD4 + T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch. (frontiersin.org)
  • Human peripheral blood lymphocytes were stained with CD195 (clone HEK/1/85a) PerCP/Cyanine5.5 (blue histogram), or rat IgG2a, κ PerCP/Cyanine5.5 (red histogram). (biolegend.com)
  • All experiments performed on PBMCs extracted from human blood stimulated with PHA and LPS for 48 hours, gated on live single cell lymphocytes, in the presence of 10% human serum. (bio-rad-antibodies.com)
  • Figure B. Alexa Fluor 647 conjugated Mouse anti Human CD3 ( MCA463A647 ) and StarBright Violet 440 conjugated Mouse anti Human CD69 ( MCA2806SBV440 ) All experiments performed on human blood stimulated with Cell Stimulation Reagent (without Brefeldin A) for 5 hours, gated on live single lymphocytes, in the presence of 10% human serum. (bio-rad-antibodies.com)
  • Studies using human samples have shown that such cells are present in dental pulps 1,2 whilst others have demonstrated the absence of those cells 3,4,5 . (bvsalud.org)
  • 2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
  • CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
  • Infiltration, accumulation, and survival of chimeric antigen receptor T (CAR-T) cells in solid tumors is crucial for tumor clearance. (nature.com)
  • The T45-2342 monoclonal antibody recognizes the mouse F4/80 antigen which is also known as EGF-like module-containing mucin-like hormone receptor-like 1 (EMR1). (bdbiosciences.com)
  • After antigen recognition and activation, CD8 + cytotoxic T cells may trigger keratinocyte apoptosis. (medscape.com)
  • Coney LR, Tomassetti A, Carayannopoulos L, Frasca V, Kamen BA, Colnaghi MI, Zurawski VR Jr: Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein. (t3db.ca)
  • The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
  • We found that most of the previously described PAR 1 -targeted agents can also activate/desensitize PAR 2 , and most of these peptides can also activate a calcium signaling pathway in a target cell that possesses PAR 2 along with PAR 1 . (aspetjournals.org)
  • Research on vitamin D regulation of thymocyte selection, Th1 and Th17 cells, T-cell programed cell death, and T-regulatory (Treg) cells is summarized and integrated into model mechanisms. (frontiersin.org)
  • However, it is still not clear how such dimeric opioid receptors are organized and what role they play in signaling. (aspetjournals.org)
  • Our findings suggest a role for ILC2 and tuft cells, along with their associated cytokine IL13 and IL25 as gatekeepers and enablers of metaplastic transformation and gastric tumorigenesis, thereby providing an opportunity to therapeutically inhibit early-stage gastric cancer through repurposing antibody-mediated therapies. (bvsalud.org)
  • Mouse anti Rat CD63 antibody 6H1 ( MCA4754GA ) used to demonstrate CD63 expressing cells by immunofluorescence. (bio-rad-antibodies.com)
  • a Immunofluorescence of CD63 (green) and mTOR (red) in INS1 cells treated with control (1% BSA, 11 mM glucose, "1% BSA") or glucolipotoxic (1% BSA, 33.3 mM Glucose and 0.4 mM Palmitate, "Glc/Pal") media for 20 h. (bio-rad-antibodies.com)
  • Immunocytochemistry/ Immunofluorescence: SREBP2 Antibody (1D2) [NBP1-54446] - SREBP2 (1D2) antibody was tested in HeLa cells with DyLight 488 (green). (novusbio.com)
  • All cells expressed DPP-4, as determined by immunofluorescence staining ( Figure 1 ) and Western blot analysis (data not shown). (cdc.gov)
  • To accomplish these aims, full length cDNA's encoding porcine and rat secretin will be cloned. (grantome.com)
  • From the nucleotide sequence of the cDNA's encoding porcine and rat secretin will be cloned. (grantome.com)
  • While much is known about the ErbB receptor binding characteristics of BTC and its effect on a variety of cultured cells under different conditions, the challenge that lies ahead is to determine the role of BTC in vivo. (embl.de)
  • Although the in vitro binding data were consistent with the in vivo study, it did not identify the binding characteristics of each of the bridged receptors. (aspetjournals.org)
  • In addition there is a lack of information regarding the presence of mast cells in dental pulp of rats, which are animals used to study important aspects of the pathophysiology of dental pulp in vivo 6 . (bvsalud.org)
  • As described below, these diverse situations range from the complications of diabetes and cellular perturbation in amyloidoses to immune and inflammatory responses and tumor cell behavior. (jci.org)
  • In mice, 7 × 19 CAR-T cells achieved complete regression of pre-established solid tumors and prolonged mouse survival, with superior anti-tumor activity compared to conventional CAR-T cells. (nature.com)
  • Depletion of recipient T cells before 7 × 19 CAR-T cell administration dampened the therapeutic effects of 7 × 19 CAR-T cell treatment, suggesting that CAR-T cells and recipient immune cells collaborated to exert anti-tumor activity. (nature.com)
  • Figure 2: Complete regression of pre-established solid tumor by treatment with 7 × 19 CAR-T cells. (nature.com)
  • Collectively, these data provide an explanation for the tumor inhibitory effect of 125I seed implantation and emphasize the important roles of apoptosis and cell cycle arrest underlying the efficacy of this modality. (cox-inhibitors.com)
  • While the resulting tuft cell - ILC2 feed-forward circuit promotes gastric metaplasia and tumor formation, genetic depletion of tuft cells or ILC2s, or therapeutic targeting of IL13 or IL25 alleviates these pathologies in mice. (bvsalud.org)
  • Structurally, LHCGR is similar to thyroid and follicle stimulating hormone receptors (TSHR and FSHR respectively). (biomedcentral.com)
  • Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. (nature.com)
  • A different experimental approach by West and Cooke [ 10 ] demonstrated the secretion of M r 80-90K hCG-LH receptor complex into the culture media from ligand-induced rat and mouse leydig cells. (biomedcentral.com)
  • The activities of adhesion and signaling receptors in platelets are controlled by several mechanisms. (frontiersin.org)
  • It has been shown that innate lymphoid cells (ILCs) play a major effector cell role in the immune response in tissue homeostasis and inflammation and fascinating details about the interaction between innate and adaptive immunity. (bvsalud.org)
  • The activation of these cells leads to the release of chemical mediators such as histamine and arachidonic acid metabolites, which increase vascular permeability and tissue swelling 9 . (bvsalud.org)
  • For AMPA receptor and filamentous actin (F-actin) labeling, neurons were fixed in warm 4% paraformaldehyde/4% sucrose in PBS for 15 min at space temp and permeabilized with 0.25% Triton X-100 for 5 min. (ole2011.org)
  • Coordinated localisation of mucins and trefoil peptides in the ulcer associated cell lineage and the gastrointestinal mucosa. (embl.de)
  • The ulcer associated cell lineage (UACL) occurs at sites of chronic ulceration in Crohn's disease, expresses all three trefoil peptides, and is implicated in mucosal restitution. (embl.de)
  • Secretin producing cells will be characterized further by combining in situ hybridization with immunocytochemistry to see if other peptides are coexpressed with secretin. (grantome.com)
  • Ramírez-Sánchez DA, Arredondo-Beltrán IG, Canizalez-Roman A, Flores-Villaseñor H, Nazmi K, Bolscher JGM, León-Sicairos N. Bovine lactoferrin and lactoferrin peptides affect endometrial and cervical cancer cell lines. (bc9.org)
  • that 125I seed irradiation affects genes associated with apoptosis and cell cycle arrest in both transcriptional and epigenetic levels. (cox-inhibitors.com)
  • Distribution, cloning and sequencing of GnRH, its receptor, and effects of gastric acid secretion of GnRH analogue in gastric parietal cells of rats. (bc9.org)