• Systemic ablation of dendritic cells (DCs) was shown to cause fatal manifestations of autoimmunity which points to their importance in central tolerance. (wikipedia.org)
  • Indeed, as mTECs represent exclusive donors of TRAs, experiments with first antigen transfer mouse models discovered thymic dendritic cells (DCs) to be so far the only known TRAs acceptors involved in antigen transfer. (wikipedia.org)
  • Plasmacytoid dendritic cells (pDCs) are the professional producers of IFN-I in response to many viruses, including all of the herpesviruses tested. (mdpi.com)
  • Method For immunopharmacological screening campaigns, we built an artificial miniature immune system in which dendritic cells (DCs) derived from immature precursors present MHC (major histocompatibility complex) class I-restricted antigen to a T-cell hybridoma that then secretes interleukin-2 (IL-2). (bmj.com)
  • He is also Leader of the Dendritic Cells (DC) Antigen Presentation research group. (euroacadti.eu)
  • His main scientific contributions in the last 10 years relate to antigen presentation in dendritic cells and immunotherapy. (euroacadti.eu)
  • Recent data demonstrate that the recruitment of dendritic cells to neoplastic lesions (and hence the priming of tumor-specific CD8 + T cells) is highly dependent on radiotherapy dose and fractionation through a mechanism that involves the accumulation of double-stranded DNA in the cytoplasm of cancer cells and consequent type I IFN release. (aacrjournals.org)
  • Cell surface recognition and cytosolic sensing of these molecules result in signaling cascades that promote rapid and localized autophagy machinery recruitment. (frontiersin.org)
  • I have used structural biology to explain pre-T-cell receptor (TCR) self-association in T-cell development, and how the TCR specifically recognises polymorphic Human Leukocyte Antigen (HLA) molecules in the context of viral immunity and aberrant T-cell reactivity. (cardiff.ac.uk)
  • Furthermore, we will give an overview of the tumor-associated antigens and immunomodulatory molecules that have been used to armor MVA and describe their clinical use. (bvsalud.org)
  • Recombinant-modified vaccinia virus Ankara (rMVA) is known to elicit potent antitumor immune responses in preclinical models due to its inherent ability to activate the innate immune system and the activation of adaptive responses mediated by the expression of tumor antigens and costimulus-providing molecules, such as CD40L and CD137L. (bvsalud.org)
  • The role of adhesion molecules in multiple sclerosis: biology, pathogenesis and therapeutic implications. (2medicalcare.com)
  • MHC class II molecules are specialized peptide receptors that play a critical role in initiating and regulating immune responses by binding peptide fragments that are 10-30 amino acids long [ 1 ] and present them on the surface of antigen-presenting cells for recognition by CD4 + T cells. (biomedcentral.com)
  • Additionally, IFNγ induces the production of cytokines, Fc receptor, and adhesion molecules and up-regulates MHC class I and II antigen expression by antigen presenting cells during an immune response. (bioxcell.com)
  • During her PhD, Abhi elucidated the regulatory role of cytokine signaling pathways in the function of lipid antigen presenting molecule CD1d and restricted innate lymphocytes, Natural Killer T (NKT) cells. (wustl.edu)
  • Their multi‑functional cargo have been indicated to regulate a vast number of biological pathways in target cells. (spandidos-publications.com)
  • Their expression in tumour cells is modulated by a complex interplay of genomic, transcriptomic and post translational factors involving multiple intracellular antigen processing pathways. (portlandpress.com)
  • Furthermore, MCs are well recognized for their prominent role in allergies but much less is known about their contributions to pain pathways in general and migraine specifically. (frontiersin.org)
  • Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
  • In addition to its role in cellular homeostasis, autophagy is essential to immunity. (frontiersin.org)
  • I have pioneered our molecular understanding of lipid-based immunity by T cells, revealing that it can differ fundamentally from peptide-mediated adaptive immunity. (cardiff.ac.uk)
  • 2023. CD4+ T cell-mediated recognition of a conserved cholesterol-dependent cytolysin epitope generates broad antibacterial immunity . (cardiff.ac.uk)
  • Second, it elicits robust and durable humoral and cellular immunity against vector-encoded heterologous antigens. (bvsalud.org)
  • Metabolic reprogramming plays an important role in tumor progression and antitumor immunity. (medsci.org)
  • However, this finding has triggered further interest in utilising tumour-specific MHC-II to harness sustained anti-tumour immunity through the activation of CD4 + T helper cells. (portlandpress.com)
  • PA group is currently developing new anticancer vaccines based on the concept of immunogenic cell death and exploring the crosstalk between angiogenesis and antitumor immunity in melanoma. (euroacadti.eu)
  • Matthew Albert is Director of Research INSERM and Head of the Laboratory of Dendritic Cell Immunobiology at the Institut Pasteur, Paris, leading a team in the area of dendritic cell immunobiology and tumor immunity. (euroacadti.eu)
  • 2018). "NKp46 Receptor-Mediated Interferon-gamma Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis" Immunity 48(1): 107-119 e104. (bioxcell.com)
  • Antigen transfer in the thymus is the transmission of self-antigens between thymic antigen-presenting cells which contributes to the establishment of T cell central tolerance. (wikipedia.org)
  • Pro-inflammatory 5-LOX metabolites were selectively increased in post COVID-19 MDM, suggesting that SARS-CoV-2 infection drives a pro-inflammatory eicosanoid reprogramming that contributes to long-term alterations in innate immune cell function. (nature.com)
  • Thereafter, Abhi carried out preclinical testing of antisense oligonucleotides against α2-Na+/K+ ATPase, which is upregulated in astrocytes and contributes to non-cell autonomous neurodegeneration in ALS. (wustl.edu)
  • Dr. Amigorena contributes to the understanding of endoplasmic reticulum recruitment and its participation in antigen uptake and cross presentation as well in the endosome migration and maturation. (euroacadti.eu)
  • 2023. CD1 lipidomes reveal lipid-binding motifs and size-based antigen-display mechanisms . (cardiff.ac.uk)
  • 2023. Complimentary electrostatics dominate T-cell receptor binding to a psoriasis-associated peptide antigen presented by human leukocyte antigen C∗06:02 . (cardiff.ac.uk)
  • 2023. The allopurinol metabolite, oxypurinol, drives oligoclonal expansions of drug‐reactive T cells in resolved hypersensitivity cases and drug‐naïve healthy donors . (cardiff.ac.uk)
  • 2023. SARS-CoV-2 breakthrough infection induces rapid memory and de novo T cell responses . (cardiff.ac.uk)
  • Only available for delegates already registered at BIOSPAIN 2023 (presenting has no additional cost). (biospain2023.org)
  • They are derived by a targeted mechanism from the cell endocytic compartment and are formed and stored within the intracellular multivesicular bodies (MVBs). (spandidos-publications.com)
  • Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport. (gu.se)
  • Exosomes are small lipid bilayer-surrounded extracellular vesicles released from cells into the extracellular space or biological fluids ( 1 , 2 ). (spandidos-publications.com)
  • Both ikarugamycin and astemizole improved the anticancer activity of the immunogenic chemotherapeutic agent oxaliplatin in a T cell-dependent fashion. (bmj.com)
  • Collectively, these studies bear the potential to significantly increase our understanding of the genetic mechanisms governing human adult β-cell function, and to expand our toolkit for genetic interrogation of human islets. (einsteinmed.edu)
  • In this review, we intend to summarize the current knowledge on the many functions of autophagy proteins in cell defenses with a focus on bacteria-macrophage interaction. (frontiersin.org)
  • These vesicles are carriers of active or non-autonomous function biomolecules, such as proteins, lipids, DNA, mRNA and non-coding regulatory RNA. (spandidos-publications.com)
  • Background Most immunotherapies approved for clinical use rely on the use of recombinant proteins and cell-based approaches, rendering their manufacturing expensive and logistics onerous. (bmj.com)
  • MHC-I and MHC-II proteins are key components of the antigen presentation machinery responsible for neoantigen presentation to CD8 + and CD4 + T lymphocytes, respectively. (portlandpress.com)
  • Apfel R, Lottspeich F, Hoppe J, Behl C, Durr G, Bogdahn U. Purification and analysis of growth regulating proteins secreted by a human melanoma cell line. (2medicalcare.com)
  • citation needed] These processes are mediated especially by unique subset of stromal cells called Medullary thymic epithelial cells (mTECs) via presentation of Tissue restricted antigens (TRAs) that represent self tissues from almost all parts of the body. (wikipedia.org)
  • In tumor-free mice, the vector coding for the triple combination was only slightly superior, whereas, in tumor-bearing animals, we observed a synergistic induction of T lymphocytes specific against vector-encoded and non-encoded tumor-associated antigens. (bvsalud.org)
  • IFNγ is primarily produced by activated lymphocytes including T, B, NK cells, and ILCs. (bioxcell.com)
  • IFNγ exerts immunoregulatory, anti-proliferative, anti-viral, and proinflammatory activities and plays an important role in activation, growth, and differentiation of T and B lymphocytes, macrophages, NK cells and other non-hematopoietic cell types. (bioxcell.com)
  • I have unearthed structural mechanisms of HLA polymorphism impacting on drug and food hypersensitivities, as well as Natural Killer cell receptor recognition. (cardiff.ac.uk)
  • The last abundant subset of thymic DCs is represented by B220+ plasmacytoid DCs (pDCs) which also rise extrathymically and transfer peripheral antigens from the periphery to the thymus to mediate selection processes. (wikipedia.org)
  • For her postdoctoral work, Abhi chose to work in neuroimmunology, whereby her initial work was focused at understanding mechanisms involved in CD4+ T cell-mediated motor neuron survival in peripheral nerve injury and amyotrophic lateral sclerosis (ALS). (wustl.edu)
  • Self-harmful T cells, further referred to as autoreactive T cells, originate in the thymus because of the stochastic process called V(D)J recombination which conducts the generation of T cell receptors (TCRs) and enables their limitless variability. (wikipedia.org)
  • Two processes of central tolerance take place in thymic medulla, namely clonal deletion (recessive tolerance) and T Regulatory cells selection (dominant tolerance) which force autoreactive T cells to apoptosis or skew them into suppressor T regulatory cells (TRegs), respectively, in order to protect body against manifestations of autoimmunity. (wikipedia.org)
  • In addition, our results lend credence to the hypothesis that the alleles DQB1*0201 and *0202 play a protective role by binding Dsg3 peptides with greater affinity than the susceptible alleles, allowing for efficient deletion of autoreactive T cells. (biomedcentral.com)
  • The multi‑dimensional nature of their roles in cellular homeostasis, cell‑to‑cell and tissue‑to‑tissue communication at the level of the organism, as well as their actions on the holobiome (intra‑/interspecies interaction), have garnered the interest of a large number of researchers. (spandidos-publications.com)
  • Endocrinology, by definition, focuses on homeostatic, and cell‑to‑cell and tissue‑to‑tissue communication mechanisms. (spandidos-publications.com)
  • Exosomes, via their cargo or surface composition, are signals/mediators of systemic homeostasis and stress for specific cell-to-cell or tissue-to-tissue communication ( 5 ). (spandidos-publications.com)
  • Recently, the lab of Dr. P. Agostinis documented that immunogenic cell death mediated by ER stress can be harnessed to develop novel and clinically relevant, next-generation dendritic cell-based immunotherapies for brain tumors. (euroacadti.eu)
  • They currently study angiogenesis and lymphatic vessels particularly in malignant tumors, focusing on the growth factor-receptor signaling and growth factor-mediated endothelial cell reprogramming. (euroacadti.eu)
  • Natural killer (NK) cells are innate lymphoid cells, and their presence within human tumors correlates with better prognosis. (bioxcell.com)
  • However, the mechanisms by which NK cells control tumors in vivo are unclear. (bioxcell.com)
  • Because of their expanding roles in the endocrine regulation of homeostasis and stress, and their involvement in human pathophysiology, exosomes are now the epicenter of a new field, termed 'exosomics' ( 3 ). (spandidos-publications.com)
  • A key mechanism of immune evasion deployed by tumour cells is to reduce neoantigen presentation through down-regulation of the antigen presentation machinery. (portlandpress.com)
  • We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)
  • Thymus represents an origin of T cell development and its responsibility is to select functional but also safe T cells which will not attack self tissues. (wikipedia.org)
  • Meanwhile, these non-engineered viruses sometimes inevitably infect and spread to normal tissues, indiscriminately killed both tumor and normal cells, causing a series of unpredicted side effects. (biomedcentral.com)
  • By the genetic recombination the viruses were conferred with high specificity against tumor cells without targeting normal tissues. (biomedcentral.com)
  • We previously demonstrated that systemic immunization with a non-replicating MVA encoding CD40 ligand (CD40L) enhances innate immune cell activation and function, and triggers potent antitumor CD8+ T cell responses in different murine tumor models. (bvsalud.org)
  • A murine breast cancer cell line was implanted into BALB/c mice. (preprints.org)
  • citation needed] Unidirectional spreading of mTEC-derived TRAs onto additional APCs via antigen transfer increases the probability of encounter between potential autoreactive T cell and its corresponding TRA and therefore enhances processes of central tolerance. (wikipedia.org)
  • Our data suggest that fetuin-A overexpression significantly enhances the invasive potential of the cells and also the expression of Toll like receptor 4 (TLR4) on these cells. (preprints.org)
  • This antigen is accompanied by an adjuvant that enhances the immune response. (biospain2023.org)
  • Yet, most of this philosopher is on one exercise or the institutional of a central news between weight used by aspiration-induced precursors to description and service and that systematized by other and available role number. (solosaur.com)
  • In addition to its role in providing precursors for placental estrogen formation, the fetal adrenal cortex may participate in the events that lead to the initiation of labor and to maturation of the fetal lungs. (medscape.com)
  • Cancer immunotherapy relies on unleashing the patient´s immune system against tumor cells. (bvsalud.org)
  • With the understanding particularly in the characteristics of viruses and tumor cells, numerous innovative OVs have been engineered to conquer cancers, such as Talimogene Laherparepvec (T-VEC) and tasadenoturev (DNX-2401). (biomedcentral.com)
  • OVT has its unique advantages and prospects, because oncolytic viruses (OVs) preferentially infect and replicate in tumor cells and destroy them, while leaving healthy cells largely untouched [ 7 ]. (biomedcentral.com)
  • His research has been focusing on the characterization of the natural immune responses towards malignant cells. (euroacadti.eu)
  • In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)
  • Serum and airway prostanoid- and LT levels are increased in severe COVID-19 10 , 11 , suggesting a role for eicosanoids in the immune response to SARS-CoV-2 infection. (nature.com)
  • We also determined the adhesion and growth potential of the cells in the presence of only fetuin-A in serum free medium and also in complete medium. (preprints.org)
  • Roles of autophagy machinery in macrophage antibacterial defenses. (frontiersin.org)
  • First, MVA is an excellent inducer of innate immune responses leading to type I interferon secretion and induction of T helper cell type 1 (Th1) immune responses. (bvsalud.org)
  • IFNγ has also been shown to modulate macrophage effector functions, influence isotype switching and induce the secretion of immunoglobulins by B cells. (bioxcell.com)
  • We demonstrated that signaling via the NK cell receptor NKp46 (human) and Ncr1 (mouse) induced interferon-gamma (IFN-gamma) secretion from intratumoral NK cells. (bioxcell.com)
  • Experiments from this study reveal that clonal deletion of autoreactive CD4+ T cells, apart from CD8+ T cells, requires indirect presentation of TRAs by bone marrow (BM) derived APCs. (wikipedia.org)
  • It works by helping the bone marrow produce normal blood cells and by killing abnormal cells in the bone marrow. (zhihuiya.com)
  • Exception is represented by thymic B cells which were shown to express TRAs and Aire. (wikipedia.org)
  • The most efficient subset in TRA presentation and both modes of central tolerance was found to be CD8α+ thymic-derived DCs (tDCs). (wikipedia.org)
  • All these thymic DC subsets were shown to participate in antigen transfer. (wikipedia.org)
  • The era of immune checkpoint blockers (ICB), which started in 2011 with the approval of an antibody targeting cytotoxic T lymphocyte-associated protein 4 (CTLA-4) on T cells (namely, ipilimumab) for the treatment of metastatic melanoma ( 1 ), has brought a new paradigm to cancer therapy whereby the immune system is being harnessed to cure the cancer. (aacrjournals.org)
  • Our recent work had shown that patients suffering from chronic airway inflammation exhibit transcriptional reprogramming of MDM 14 , a cell type implicated in COVID-19 pathogenesis 7 . (nature.com)
  • We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
  • Her current work aims to understand TREM2 signaling in neurodegenerative diseases in human induced pluripotent stem cell (iPSC)-differentiated microglial cells. (wustl.edu)
  • Innovative Genetic Technologies For Identifying Novel Regulatory Mechanisms Controlling Human b-Cell Maturation and Function. (einsteinmed.edu)
  • Importantly, hallmark functions of human pancreatic β cells improve in the years after birth. (einsteinmed.edu)
  • Recent studies have revealed numerous potential regulators of adult islet function, many of which are not expressed in mouse or immature human β-like cells. (einsteinmed.edu)
  • Understanding the genetic and molecular mechanisms regulated by these factors in adult human islets could uncover novel druggable targets for diabetes treatment and improve outcomes with β-cells from renewable sources. (einsteinmed.edu)
  • I also combined primary human islet organoid systems ("pseudoislets") with a variety of genetic approaches, including lenti-shRNAs and lenti-CRISPR, to study their roles in the adult β-cell and discover how they are regulated by non-coding mechanisms. (einsteinmed.edu)
  • Importantly, these are unique to human beta cell/islet maturation: they are not expressed in adult mouse islet cells or β-like cells from renewable sources. (einsteinmed.edu)
  • Overall, the experiments proposed here should prioritize novel regulators of adult human β-cell function. (einsteinmed.edu)
  • Specific Aim 1: Elucidate The Roles Of Novel Age-Dependent TFs in Primary Human β-Cells. (einsteinmed.edu)
  • Specific Aim 2: Establish CRISPR-RNP-Mediated Gene Editing in Primary Human β-Cells. (einsteinmed.edu)
  • And fourth, its replication deficit in human cells ensures a excellent safety profile. (bvsalud.org)
  • Bayas A, Hummel V, Kallmann BA, Karch C, Toyka KV, Rieckmann P. Human cerebral endothelial cells are a potential source for bioactive BDNF. (2medicalcare.com)
  • STARD12 co-expressed genes participated in cell cycle and DNA replication, and STARD14 were enriched in ECM-receptor interaction. (medsci.org)
  • This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
  • Astemizole induced the production of IL-2 and interferon-γ (IFN-γ) by CD4 + and CD8 + T cells both in vitro and in vivo. (bmj.com)
  • Our docking simulations are entirely consistent with functional data obtained from in vitro competitive binding assays and T cell proliferation studies in DR4 and DR6 PV patients. (biomedcentral.com)
  • In this work, we designed and built light sources based upon commercially available Organic Light Emitting Diode (OLED) and LED parts to experimentally validate the combination with methylene blue photosensitizer to kill Leishmania major and Crithidia fasciculata cells in vitro. (peertechzpublications.org)
  • He received his BA in Biochemistry at Case Western Reserve University, but his research interests later moved toward less-biased descriptions of cancer heterogeneity through employment of bioinformatics, single-cell, and multi-omics pipelines (e.g., proteogenomics, ssATAC-seq, etc. (wustl.edu)
  • In mobile populations, characteristics and time of acquisition of infections depend on exposure in the original country, during migration, and in the resettlement environment, leading to considerable heterogeneity in presentation. (cdc.gov)
  • BRD4 inhibitor expanded CD4+ and CD8+ T cell populations and reduced the population of monocytic myeloid-derived suppressor cells (M-MDSCs). (preprints.org)
  • However, its dual role in both the activation and suppression of innate immune responses makes it very difficult to use the results from gathered basic research and apply them to the development of clinical trials. (mdpi.com)
  • We discuss the current knowledge about sex differences in migraine and its comorbidities, and focus on the potential role of mast cells (MCs) in both. (frontiersin.org)
  • MC-neuron bidirectional communication uniquely positions these cells as potential initiators and/or perpetuators of pain. (frontiersin.org)
  • The present studies were undertaken to address the role of fetuin-A in the growth and invasion potential in a triple negative breast cancer (TNBC) cell line, MDA-MB-468. (preprints.org)
  • We overexpressed fetuin-A in MDA-MB-468 and then determined the invasive potential of fetuin-A overexpressing cells vs controls transfected with empty vector. (preprints.org)
  • Taken together, the data suggest that fetuin-A-TLR4 signaling network plays a significant role in the growth and invasion potential of TNBC. (preprints.org)
  • Amazing combination of therapeutic strategies of OVs and immune cells confers immense potential for managing cancers. (biomedcentral.com)
  • As an alternative approach to such conventional inhibitors, the first-in-class small molecule sEH degraders were recently developed by our group that promote the degradation of sEH within cells with superior cellular efficacy compared to sEH inhibitors. (einsteinmed.edu)
  • Recently my team has provided a structural basis of how vitamin B metabolites can be presented and recognised by the immune system, revealing a new class of antigen. (cardiff.ac.uk)
  • Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. (zhihuiya.com)
  • The combination of astemizole and oxaliplatin was able to cure the majority of mice bearing orthotopic non-small cell lung cancers (NSCLC), then inducing a state of protective long-term immune memory. (bmj.com)
  • The NSCLC-eradicating effect of astemizole plus oxaliplatin was lost on depletion of either CD4 + or CD8 + T cells, as well as on neutralization of IFN-γ. (bmj.com)
  • Non-small cell lung cancer (NSCLC) accounts for 85-90% of cases, while lung adenocarcinoma (LUAD) is the most common subtype [ 2 ]. (medsci.org)
  • Robust SARS-CoV-2 T cell responses with common TCR? (cardiff.ac.uk)
  • Some roadblocks for a successful cancer vaccine in the clinic include the tumor antigen of choice, the adjuvants employed to strengthen antitumor-specific immune responses, and the risks associated with enhancing immune-related adverse effects in patients. (bvsalud.org)
  • B cell responses to the PNS protein P0 in experimental autoimmune neuritis. (2medicalcare.com)
  • In patients with cancer, high H1R1 expression correlated with low infiltration by TH1 cells, as well as with signs of T-cell exhaustion. (bmj.com)
  • Ongoing research investigates mechanisms invoked by cancer cells to abrogate MHC-I expression and attenuate anti-tumour CD8 + cytotoxic T cell response. (portlandpress.com)
  • This review provides a comprehensive overview of physiologically conserved or novel mechanisms utilised by tumour cells to reduce MHC-I or MHC-II expression. (portlandpress.com)
  • Dr. Allison is a leader in the field of immunology, particularly in developing ways to help the immune system recognize and destroy cancer cells. (euroacadti.eu)
  • Her current research in Dr. Joel Schilling's lab focuses on Kupffer cell metabolism and lysosomal function during non-alcoholic fatty liver disease. (wustl.edu)
  • All forms of diabetes are consequence of impaired function or survival of pancreatic islet b cells. (einsteinmed.edu)
  • The profound roles of exosomes in homeostasis, stress and several pathological conditions, in conjunction with their selective and cell‑specific composition/function, allude to their use as promising circulating clinical biomarkers of systemic stress and specific pathologic states, and as biocompatible vehicles of therapeutic cargo. (spandidos-publications.com)
  • Inhibition of experimental autoimmune neuritis by an antibody to the lymphocyte function-associated antigen-1. (2medicalcare.com)
  • Isolation and characterization of an oligodendrocyte precursor-derived B-cell epitope in multiple sclerosis. (2medicalcare.com)
  • Autophagy is a well-conserved lysosomal degradation pathway that plays key roles in bacterial infections. (frontiersin.org)
  • Multiple studies have shown that transcription factors play a critical role in regulating β-cell maturation. (einsteinmed.edu)
  • It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. (zhihuiya.com)
  • Giving DEC-C in combination with venetoclax may kill more cancer cells in patients with relapsed AML. (zhihuiya.com)
  • Moreover, HSV engineered in gH of a scFv targeting the cancer-specific HER2 receptor, scFv-HER2-gH chimera, can enter, replicate and kill cancer cells efficiently [ 14 ]. (biomedcentral.com)
  • Thus, we have defined a mechanism of NK cell-mediated control of metastases in vivo that may help develop NK cell-dependent cancer therapies. (bioxcell.com)
  • Since 2000 PA is the group leader of the Cell Death Research & Therapy lab, at the Department of Cellular & Molecular Medicine of the KU Leuven, and in 2008 she became Full Professor at the same Institution. (euroacadti.eu)
  • 3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
  • PA started her own research group in 1996 with a focus on mechanisms of cancer cell death induced by irradiation. (euroacadti.eu)
  • As with other medical conditions, research and clinical studies unveiled new information about this condition, including reports of a similar presenting group of symptoms in children. (ceufast.com)
  • STARD14 was negatively associated with the infiltration of CD8+T cells, while positively with CCL28 and immune checkpoints, including CTLA4 as well as PD-L2. (medsci.org)