TNF-Related Apoptosis-Inducing LigandApoptosis Regulatory ProteinsApoptosisLigandsCaspasesCaspase 3Proto-Oncogene Proteins c-bcl-2Inhibitor of Apoptosis ProteinsIn Situ Nick-End LabelingFas Ligand ProteinDNA FragmentationCell Line, Tumorbcl-2-Associated X ProteinSignal TransductionCell SurvivalCells, CulturedX-Linked Inhibitor of Apoptosis ProteinCaspase 9Caspase InhibitorsCaspase 8CASP8 and FADD-Like Apoptosis Regulating ProteinMitochondriaApoptosis Inducing FactorTumor Necrosis Factor-alphaEnzyme ActivationCell ProliferationCytochromes cTumor Cells, CulturedTumor Suppressor Protein p53Cell LineBlotting, Westernbcl-X ProteinFlow CytometryAnnexin A5Amino Acid Chloromethyl KetonesMembrane GlycoproteinsProto-Oncogene ProteinsAntineoplastic AgentsCysteine Proteinase InhibitorsTransfectionMice, Inbred C57BLCell CycleReactive Oxygen SpeciesDose-Response Relationship, DrugDown-RegulationPoly(ADP-ribose) PolymerasesEnzyme InhibitorsRNA, Small InterferingRNA, MessengerCell DivisionJurkat CellsReceptors, Tumor Necrosis FactorZuclomipheneUp-RegulationPhosphorylationNF-kappa BCell DeathCaspase 7Reverse Transcriptase Polymerase Chain ReactionMice, KnockoutTime FactorsHL-60 CellsProtein BindingGenes, bcl-2Proto-Oncogene Proteins c-aktCD40 LigandImmunohistochemistryGene Expression RegulationNecrosisMembrane ProteinsCarrier Proteinsbcl-2 Homologous Antagonist-Killer ProteinReceptors, TNF-Related Apoptosis-Inducing LigandCytochrome c GroupMolecular Sequence DataPhenanthridinesEpithelial CellsMyeloid Cell Leukemia Sequence 1 ProteinOxidative StressBH3 Interacting Domain Death Agonist ProteinDNA DamageGene ExpressionDrug Synergismbcl-Associated Death ProteinStaurosporineCeramidesAntineoplastic Agents, PhytogenicMice, NudeReceptors, Tumor Necrosis Factor, Type IHeLa CellsRNA InterferenceRecombinant ProteinsProtein-Serine-Threonine KinasesRats, Sprague-DawleyT-LymphocytesMice, Inbred BALB CFas-Associated Death Domain ProteinNeoplasm ProteinsCaspase 2Models, Biological