• Knockout mice without CRABP1 showed increased neural stem cell proliferation and thus hippocampus neurogenesis. (wikipedia.org)
  • When CRABP1 was knocked down the apoptotic induction ability was also removed and allowed for cell proliferation. (wikipedia.org)
  • Figure 2 illustrates both pathways of retinoic acid binding to CRABP for cell proliferation and apoptotic activity. (wikipedia.org)
  • Single-cell RNA-sequencing (scRNA-seq) analysis of thousands of DIPG tumor cells containing H3K27M mutations showed that most of these tumor cells resemble oligodendrocyte precursor cells (OPC-like)-a cell type that exhibits obviously enhanced proliferation and tumor-propagating potential compared with other cell subsets in tumor samples 9 . (nature.com)
  • Extracts prepared from Trametes versicolor under the trade name of I'm-Yunity exhibit anti-tumorigenic activities, as supported by inhibition of the proliferation and induction of apoptosis in malignant cells. (spandidos-publications.com)
  • Recent study showed that iASPP could impact the proliferation and apoptosis of leukemia cells by interacting with FHL2 . (nature.com)
  • Jude CD, Gaudet JJ, Speck NA, Ernst P. Leukemia and hematopoietic stem cells: balancing proliferation and quiescence. (nature.com)
  • Tight control of the cell cycle in eukaryotic cells exists to control proliferation, differentiation or apoptosis. (benthamscience.com)
  • However, the underlying mechanisms involved in the induction of genomic instability, genotoxicity, mutations and consequent increased cell proliferation are still a matter of intense research. (benthamscience.com)
  • In addition, after the overexpression or knockdown of PAK3 in cells, the proliferation, migration and invasion abilities of these cells were assessed by Cell Counting Kit-8 (CCK-8), wound healing and Transwell assays, and the results were confirmed in vivo experiments in mice. (jcancer.org)
  • We subsequently confirmed that PAK3 was overexpressed in HCC clinical samples and HCC cell lines and that PAK3 promoted the proliferation, migration and invasion of HCC cells in vitro . (jcancer.org)
  • 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)-test was used to observe the proliferation of human breast cancer MCF-7 and MDA-MB-231 cells induced on VALD-3. (researchsquare.com)
  • Inhibits proliferation and promotes osteogenic differentiation, while inhibiting adipogenic differentiation, of human amnion-derived mesenchymal stem cells (MSCs) and rabbit bone marrow-derived MSCs (Wu et al. (stemcell.com)
  • Decreased proliferation and Nanog expression in mouse embryonic stem (ES) cells, with increased erythroid differentiation (Chae et al. (stemcell.com)
  • However, it increases proliferation rates in some cell types (e.g. mesenchymal stem cells, osteosarcoma cells, HUVECs) which puts extra demands on nutrient supply and waste removal [1,2,3] . (reprocell.com)
  • The systems have been shown to improve cell proliferation and specific protein expression beyond that seen for static 3D cultures [4,5,6,7] . (reprocell.com)
  • The levels of glucose and secreted lactate contained in the cell culture medium were monitored as indicators of metabolic depletion, while protein syntheses and cell proliferation were measured by expression of phosphorylated Ribosomal protein S6 and cyclin D1. (reprocell.com)
  • Results suggested that perfusion culture reduces hypoglycemia, anaerobic stress, and preserves protein synthesis and cell proliferation. (reprocell.com)
  • decreased cell proliferation, cell cycle arrest, and induction of apoptosis. (123dok.net)
  • It was suggested that HOXD9 contributes to both cell proliferation and/or cell survival. (123dok.net)
  • HOXD9 siRNA treatment of SK-MG-1 SP cells resulted in reduced cell proliferation. (123dok.net)
  • Conclusions: Our results suggest that HOXD9 may be a novel marker of GCSCs and cell proliferation and/or survival factor in gliomas and glioma cancer stem-like cells, and a potential therapeutic target. (123dok.net)
  • Homeobox proteins are master regulators of develop-ment and control many cellular processes, including proliferation, apoptosis, cell shape, and cell migration. (123dok.net)
  • ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)
  • In this study, we investigated the role of autophagy and apoptosis in Newcastle disease virus (NDV)-infected chicken cells and tissues. (immune-source.com)
  • Prior analysis reported that a goose-source NDV stress, Herts/33 (genotype II) activated autophagy and function Vegfb of autophagy in NDV duplication and apoptosis in 1d outdated SPF hens. (immune-source.com)
  • Body 8 evaluation of rapamycin (Hip hop), chloroquine (CQ) and mock-treated poultry groupings contaminated with NDV To additional investigate the function of autophagy in apoptosis and and had been downregulated in the NDV-infected spleen, recommending that the spleen ignored the development of autophagosomes thereby. (immune-source.com)
  • Therefore, our results exhibited that autophagy was essential for NDV replication and apoptosis. (immune-source.com)
  • These data indicate that the inhibition of autophagy promotes apoptosis as described for herpes simplex computer virus 1 and mouse herpesvirus 68 [41]. (immune-source.com)
  • However, we could not demonstrate unique functions of autophagy and apoptosis in response to NDV contamination. (immune-source.com)
  • The process of autophagy in mammalian cells involves six principal actions: initiation, nucleation, elongation, closure, maturation, buy 480-11-5 and degradation [27]. (immune-source.com)
  • In bottom line, we confirmed that autophagy brought about by genotype VII NDV infections was important for virus-like replication, NDV-induced apoptosis, and cell survival in buy 480-11-5 chicken cells and tissues. (immune-source.com)
  • PP2A activity promotes the stem cells renewal ability during the differentiation process. (wikipedia.org)
  • We discovered that activation of BMP signaling promotes the exit of DIPG tumor cells from 'prolonged stem-cell-like' state to differentiation by epigenetically regulating CXXC5, which acts as a tumor suppressor and positive regulator of BMP signaling. (nature.com)
  • Thus, targeting the prolonged stem-cell-like state of DIPG cells to differentiation has been proposed as a potential strategy for DIPG treatment. (nature.com)
  • Mouse studies have suggested that Acvr1 G328V cooperates with Hist1h3b K27M and Pik3ca H1047R to generate high-grade diffuse gliomas, specifically by arresting the differentiation of oligodendroglial lineage cells 16 . (nature.com)
  • Differentiation and apoptosis have cell cycle withdraw in common, while cancer and degenerative processes both show altered control of the cell cycle. (benthamscience.com)
  • Experiments revealed that the fusion protein activates unusual signaling pathways during PSC differentiation leading to changes in cycling and survival of the red cells. (ca.gov)
  • Unlimited self renewal capacity and differentiation potential make human pluripotent stem cells (PSC) a promising source for the ex vivo manufacture of red blood cells (RBC) for safe transfusion. (ca.gov)
  • Induces upregulation of the pluripotency network genes (Klf4, Klf2, Nanog, Oct4, Myc, Sox2) and epigenetic-associated proteins (Dnmt3a, Mbd3) in mouse ES cells, and inhibits retinoic acid-induced differentiation (Adamo et al. (stemcell.com)
  • Promotes differentiation and mineralization of MC3T3-E1 osteoblastic cells (Kanazawa et al. (stemcell.com)
  • Stem cells derived from human dental tissues with properties of self-renewal, multilineage differentiation and immunomodulation have been intensively investigated for stem cell-based regenerative medicine [ 1 , 2 ]. (biomedcentral.com)
  • A switch from glycolysis to mitochondrial respiration drives these cells toward differentiation, but the mechanisms that control this switch are poorly defined. (lww.com)
  • A multitude of pathways control cyclin-dependent kinase activities as the major event for cell cycle progression. (benthamscience.com)
  • and effects on the cell cycle progression, action on the apoptosis induction, of leaf and stem extracts of R. rosaefolius, in HepG2/C3A cells (Human hepatoma). (fapesp.br)
  • For this, the first stage of the work will seek to observe effects of cytotoxicity of the extract, by MTT test, trypan blue staining, genotoxicity by comet and micronucleus assays, and on cell cycle progression and induction of apoptosis, by flow cytometry. (fapesp.br)
  • This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. (cancerindex.org)
  • Substantial data have provided convincing evidence establishing that human cancers emerge from cancer stem cells (CSCs), which display self-renewal and are resistant to anticancer drugs, radiation, and apoptosis, and express enhanced epithelial to mesenchymal progression. (oaepublish.com)
  • In cancer progression, FOXO3a inhibition stimulates cell transformation and angiogenesis ( 9 ). (spandidos-publications.com)
  • The development and progression of tumors is taught on a molecular genetic and cell biological basis. (tum.de)
  • is known to exert anticancer effects, such as inducing cell cycle arrest, inhibiting metastasis, and overcoming immunotherapy resistance in breast cancer cells. (hindawi.com)
  • This study aimed to explore the potential targets and molecular mechanisms of HNK on metastatic BCSC (mBCSC)-cell cycle arrest and the impact of the TME. (hindawi.com)
  • Flow cytometry analysis showed that VALD-3 triggered cell cycle arrest and induced apoptosis of breast cancer cells. (researchsquare.com)
  • This study is the first to show that VALD-3 induces apoptosis and cell cycle arrest in human breast cancer cells by suppressing Wnt/β-catenin signaling, indicating that it could be a potential drug for the treatment of breast cancer. (researchsquare.com)
  • FOXO3a is considered an evolutionarily conserved transcription factor involved in various cellular processes, including cell cycle arrest, DNA repair and tumor suppression ( 8 ). (spandidos-publications.com)
  • AKT activation upregulates the GATA-1 and FOXO3 transcriptional pathways with resulting inhibition of apoptosis, modulation of cell cycle and enhanced maturation of erythroid cells. (ca.gov)
  • This review focuses on an up-to-date understanding of the functions of E3 ligases in cancers and debates the perspectives of cancer cells that rely on inhibition or activation of ubiquitylation of target proteins. (bmbreports.org)
  • CRABP1 activity can thus extend the cell cycle, e.g. in embryonic and neural stem cells. (wikipedia.org)
  • It was observed that CRABP1 regulated ERK1/2) which in turn activates the protein phosphatase 2A (PP2A) that induces apoptosis of cancer cells and lengthens the cell cycle of embryonic stem cells. (wikipedia.org)
  • Highly expressed in embryonic stem cells (ESCs). (joplink.net)
  • Erythropoiesis from human embryonic stem cells through erythropoietin-independent AKT signaling. (ca.gov)
  • In addition, the red cells produced are of an immature type, expressing mostly embryonic rather than adult hemoglobin. (ca.gov)
  • The goal of the present study was to investigate the potential of ic-MPL dimerization to induce erythropoiesis from human embryonic stem cells (hESC) and to identify the signaling pathways activated by this strategy. (ca.gov)
  • By embryonic day 15.5, kidneys of nephron progenitor cell-specific VHL knockout mice begin to exhibit reduced maturation of nephron progenitors. (lww.com)
  • Background: HOX genes encode a family of homeodomain-containing transcription factors involved in the determination of cell fate and identity during embryonic development. (123dok.net)
  • In vitro neurosphere assays revealed striking increases in the number of neurosphere forming cells from p107 −/− brains that exhibited enhanced capacity for self-renewal. (rupress.org)
  • Transcreener assays are not validated with cell lysates, blood, serum, or other biological samples. (bellbrooklabs.com)
  • Experts with a good knowledge of cell-based assays and handling software & instruments are required for their optimum utilization. (emailwire.com)
  • BCSCs can develop into many cell types and repopulate heterogeneous tumors following conventional chemotherapy or radiotherapy [ 4 , 6 ]. (hindawi.com)
  • A Non-Aggressive, Highly Efficient, Enzymatic Method for Dissociation of Human Brain-Tumors and Brain-Tissues to Viable Single-Cells. (worthington-biochem.com)
  • The biological importance of activation targets of Nanog, Oct4, SOX-2, and c-Myc in CSCs, which are more frequently overexpressed in poorly differentiated tumors than in well-differentiated tumors, has been shown by correlating signature characteristics of these cells and poor survival [ 3 ] . (oaepublish.com)
  • Results: DMC significantly reduced tumor weights and volumes of HeLa cell xenografts in mice, indicating the suppression of growth of xenograft tumors. (iiarjournals.org)
  • This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. (cancerindex.org)
  • Cell adhesion molecule-1 (CADM1) is a member of the immunoglobulin superfamily that functions as a tumor suppressor of lung tumors. (cancerindex.org)
  • Extragonadal germinal cell tumors (EGGCTs) are rare tumors that predominantly affect young males. (medscape.com)
  • The only known risk factor for extragonadal germ cell tumors is Klinefelter syndrome (47XXY), which is associated with mediastinal nonseminomatous germ cell tumors, which are characterized by their location on the midline from the pineal gland to the coccyx. (medscape.com)
  • [ 1 , 2 ] In extragonadal germ cell tumors, no evidence of a primary malignancy is present in either the testes or ovaries by radiologic imaging or physical examination. (medscape.com)
  • Controversy remains regarding the origin of extragonadal germ cell tumors. (medscape.com)
  • The classic theory suggests that germ cell tumors (GCTs) in these areas are derived from local transformation of primordial germ cells misplaced during embryogenesis. (medscape.com)
  • According to this theory, the differences in phenotypes expressed by mediastinal germ cell tumors (MGCTs) and gonadal germ cell tumors may be explained by differences in the cellular environment between the gonad and the anterior mediastinum. (medscape.com)
  • Some retroperitoneal extragonadal germ cell tumors may represent metastases from a testicular cancer , with subsequent spontaneous necrosis of the primary tumor. (medscape.com)
  • Literature suggests that the only known risk factor for extragonadal germ cell tumors (EGCTs) is Klinefelter syndrome (47XXY), which is associated with mediastinal nonseminomatous germ cell tumors. (medscape.com)
  • Extragonadal germ cell tumors produce a rich symptomatology and may reach large volumes if they arise in silent areas. (medscape.com)
  • Hematologic malignancies are frequently associated with mediastinal germ cell tumors. (medscape.com)
  • Highly differentiated yolk-sac tumors make up 30% of mediastinal germ cell tumors, providing a possible basis for this association. (medscape.com)
  • The balance of the p53-mdm2 interaction has been shown to be disrupted in intracranial germ cell tumors (ICGCTs). (medscape.com)
  • A ) Active caspase-3 expression was detected by flow cytometry in HeLa, SiHa, and ME-180 cells after treatment with IC 25 and IC 50 of MNBE for 24 h. (biomedcentral.com)
  • Flow cytometry is a powerful technique for the analysis of multiple parameters of individual cells within heterogeneous populations. (cabd.es)
  • Breast cancer stem cells (BCSCs) play a critical role in chemoresistance, metastasis, and poor prognosis of breast cancer. (hindawi.com)
  • Breast cancer stem cells (BCSCs) are one of the main factors driving chemoresistance, thereby contributing to poor prognosis and clinical outcomes [ 3 - 5 ]. (hindawi.com)
  • Pediatric Brain Tumor Cancer Stem Cells: Cell Cycle Dynamics, DNA Repair, and Etoposide Extrusion. (worthington-biochem.com)
  • Emerging evidence suggests that cancer stem cells (CSCs), a subpopulation of tumor cells, have the properties of self-renewal, heterogeneous progeny, drug-resistance, and carcinogenesis in vitro and in vivo ( 4 , 5 ). (spandidos-publications.com)
  • Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells. (123dok.net)
  • Finally, we cultured human glioma cancer stem cells (GCSCs) from patient specimens found with high expression of HOXD9 in GCSCs compared with normal astrocyte cells and neural stem/progenitor cells (NSPCs). (123dok.net)
  • called either cancer stem cells (CSCs) or tumor-initiat-ing cells[3]. (123dok.net)
  • Plays a key role in increased proteasome activity in bryonic st cells (ESCs): its high expression in ESCs promotes enhanced assbly of the 26S proteasome, followed by higher proteasome activity. (joplink.net)
  • Hematopoietic Stem Cell and Leukaemic Stem Cell environmental stress responses (In vitro biomimicry of hypoxia, normoxia, hypothermia, hyperthermia, hypoglycemia and hyperglycemia): Effect on cellular growth, cell cycle distribution, apoptosis and cellular metabolism. (imperial.ac.uk)
  • Background/Aim: Demethoxycurcumin (DMC), a derivate of curcumin from natural plants, exerts antitumor effects on various human cancer cells in vitro and in vivo. (iiarjournals.org)
  • Rat primary astrocytes were isolated from different brain regions (cortex, cerebellum, and hippocampus) and grown in vitro to demonstrate the utilization of live-cell analysis for monitoring and comparing the diversity of cultured astroglia phenotypes. (news-medical.net)
  • Three-dimensional (3D) in vitro culture can improve the performance and physiological relevance of immortalized and primary cells. (reprocell.com)
  • If this is the kind of results you want to achieve with your in vitro cell models, then adding perfusion can be done with minimal disruption to your existing protocols. (reprocell.com)
  • In vitro expansion of mesenchymal stem cells using 3-D matrix derived from cardiac fibroblast. (reprocell.com)
  • However, whether casticin inhibits in vitro carcinogenesis and cancer stem cell (CSC) characteristics, and whether casticin activates FoxO3a in small cell lung cancer (SCLC) cells remain unclear. (spandidos-publications.com)
  • However, whether casticin inhibits in vitro carcinogenesis and CSC characteristics in the SCLC H446 cell line, and activates FoxO3a remains unclear. (spandidos-publications.com)
  • The tremendous ability of pluripotent stem cells (PSC) to generate diverse cell types has led to the possibility that these cells may one day be used as an inexhaustible supply of cells and tissue for therapy. (ca.gov)
  • Moreover, ethanolic extracts of I'm-Yunity-Too exhibited more potent activity compared to its aqueous extracts with regard to suppression of the growth and induction of apoptosis, as assayed by the more pronounced downregulation of phosphorylation of Rb and increased cleavage of poly(ADP‑ribose) polymerase (PARP) from its native 112-kDa form to the inactive 89-kDa product. (spandidos-publications.com)
  • Study of the cytotoxicity, genotoxicity, cell cycle monitoring, induction of apoptosis, and gene expression of Rubus rosaefolius leaves and stems extracts in human cultured cells. (fapesp.br)
  • During summer 2014, a 63-year-old woman with symptomatic high tumor burden follicular lymphoma achieved a complete clinical and radiologic response to induction treatment with 6 cycles of bendamustine and obinutuzumab, then began maintenance therapy with obinutuzumab for 8 weeks. (cdc.gov)
  • Complex haploinsufficiency in pluripotent cells yields somatic cells with DNA methylation abnormalities and pluripotency induction defects. (cdc.gov)
  • Previously, he was the Principal Investigator and lead of his lab at The Institute of Molecular and Cell Biology (IMCB) . (lifeboat.com)
  • Molecular Biology of the Cell , 7th edition. (sfu.ca)
  • The use of real-time, live-cell analysis provides new possibilities and cell biology workflows. (news-medical.net)
  • In this post, we will explore two examples of how perfusion systems can help improve the relevance of your 3D cell culture, based on two publications from Alvetex users in the field of developmental biology and cancer. (reprocell.com)
  • Cell and developmental biology of multicellular eukaryotic organisms. (unh.edu)
  • General basics of molecular cell biology are also taught, especially in the first part, while the second part focuses on translational aspects. (tum.de)
  • After successful completion of the module, students will have in-depth knowledge of cell biology and molecular biology from all aspects of tumor biology. (tum.de)
  • 2) Textbook of Molecular Cell Biology, Alberts et al. (tum.de)
  • For nearly a quarter century Molecular Biology of the Cell has been the leading cell biology textbook. (textbookrush.com)
  • This tradition continues with the new Fifth Edition, which has been completely revised and updated to describe our current, rapidly advancing understanding of cell biology. (textbookrush.com)
  • And for the first time, Molecular Biology of the Cell now contains end-of-chapter questions. (textbookrush.com)
  • The Media DVD-ROM holds the multicellular systems chapters (21-25) of the text as well.By skillfully extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and thereby create a coherent framework through which readers may approach and enjoy this subject that is so central to all of biology. (textbookrush.com)
  • There is also a reference edition of Molecular Biology of the Cell, Fifth Edition (ISBN 978-0-8153-4111-6) that contains Chapters 1-25 entirely in printed format. (textbookrush.com)
  • CSCs represent a heterogeneous tumor cell population and lack specific cellular targets, which makes it a great challenge to target and eradicate them. (oaepublish.com)
  • Several mechanisms participate in the drug and apoptosis resistance phenotype in CSCs in various cancers. (oaepublish.com)
  • Studying such mechanisms not only provides mechanistic insights into these cells that are unresponsive to drugs, but may lead to the development of targeted and effective therapeutics to eradicate CSCs. (oaepublish.com)
  • This article will review the CSCs drug and apoptosis resistance mechanisms and how to target CSCs. (oaepublish.com)
  • The intersection between the differentially expressed genes (DEGs) and the HNK-targets was determined using a Venn diagram, and the results were analyzed using a protein-protein interaction network, hub gene selection, gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses, genetic alteration analysis, survival rate, and immune cell infiltration levels. (hindawi.com)
  • Two biochemical processes, protein phosphorylation/dephosphorylation and ubiquitin-mediated degradation drive cell cycle control. (benthamscience.com)
  • In this paper we found that if we introduced a synthetic "fusion" protein into PSC, we could produce significantly more red cells in culture and that those cells were also more mature. (ca.gov)
  • We also found that the synthetic protein acts to increase red cell production independently of the well known growth factor erythropoietin. (ca.gov)
  • The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. (cancerindex.org)
  • The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. (cancerindex.org)
  • To study the potential role in this metabolic shift of von Hippel-Lindau (VHL), a protein component of a ubiquitin ligase complex, the authors generated nephron progenitor cell-specific VHL knockout mice. (lww.com)
  • The cell carrying this abnormality is relatively protected against apoptotic death because of the oncogenic effect of CCND2, leading to re-initiation of cell cycle and genomic instability. (medscape.com)
  • At the cellular and whole organ level, degenerative changes that are a hallmark of natural aging (shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, and apoptosis, accompanied by diminished elasticity) reach pathological levels in aging humans in the form of chronic respiratory disease. (karger.com)
  • Adult p107-null mice had elevated numbers of proliferating progenitor cells in their lateral ventricles. (rupress.org)
  • To investigate the anti-inflammatory activity of Shengfupian polysaccharides, LPS was used to induce inflammation in RAW264.7 cells. (bvsalud.org)
  • The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential. (nature.com)
  • Conversely, FOXO3a overexpression suppresses cancer cell growth, induces apoptosis, and reduces tumor size by regulating downstream effectors ( 10 ). (spandidos-publications.com)
  • In occasional cells, this crossing over may lead to increased 12p copy number and overexpression of cyclin D2. (medscape.com)
  • While much work has focused on the failure of epithelial cell populations as a key component of the aging process, additional studies have shown that aging, as a global phenomenon in the lung, also impacts resident endothelial, mesenchymal, and immune cell populations. (karger.com)
  • 8 Astrocytes interact with blood vessels, pericytes, and epithelial cells to organize CNS flow and modulate the blood-brain barrier (BBB). (news-medical.net)
  • In this review, we examine aging as a process dependent on specific changes in molecular pathways within multiple lung cell populations. (karger.com)
  • Chemoresistance, or the insensitivity of cancer cells to drug therapy, is a major factor in the failure of chemotherapy against breast cancer. (hindawi.com)
  • In this study, we investigated the cytotoxic and apoptotic effects of VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, on human breast cancer cells and the possible underlying mechanisms. (researchsquare.com)
  • VALD-3 also regulated the Wnt/β-catenin signaling pathway in breast cancer cells, inhibiting the activation of downstream molecules. (researchsquare.com)
  • By xenografting human breast cancer cells into nude mice, we found that VALD-3 significantly suppressed tumor cell growth while showing low toxicity against major organs. (researchsquare.com)
  • Specific areas of interest include understanding the mechanisms, which allow cancer cells to develop resistance to chemotherapy at the cellular and molecular levels. (sc.edu)
  • Patients with prolonged neutropenia after hematopoietic stem cell transplantation or chemotherapy and patients receiving broad-spectrum antibiotics and high doses of corticosteroids are predisposed to fungal infections. (msdmanuals.com)
  • mdm2 sequesters p53 and inhibits its function as G1-S checkpoint controller and apoptosis inducer. (medscape.com)
  • In glioma CSC (GCSC), the expression of some neural stem markers, such as SOX2 and Musa-shi-1, has been reported[6,7]. (123dok.net)
  • CRABP1 activates the extracellular signal-regulated kinase, ERK1 and ERK2 kinases, which are involved in the cell cycle. (wikipedia.org)
  • Extracellular vesicles derived from mesenchymal stem/stromal cells (MSCs) have shown therapeutic effects on liver fibrosis. (biomedcentral.com)
  • However, the molecular mechanisms of action of HNK in BCSCs, as well as its effects on the cell cycle, remain unclear. (hindawi.com)
  • Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. (nature.com)
  • Chronic lymphoid leukaemia and hairy cell leukaemia due to chronic exposure to benzene: Report of three cases. (cdc.gov)
  • Cell cycle analysis showed an accumulation of tumor cells predominantly in 511296-88-1 manufacture G0/G1 phase with an increase in concentration of TD-MSCs, which was confirmed by increased mRNA expression of cell cycle negative regulator p21. (immune-source.com)
  • In patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT), however, EFS and OS were not significantly different between FHL2 or iASPP high- and low-expression groups. (nature.com)
  • The number, diversity, and complexity of astroglia cells have increased significantly with evolution, and research from several groups implies that gender differences exist. (news-medical.net)
  • Apoptosis of tumor cells increased significantly as concentration of cocultured TD-MSCs increased. (immune-source.com)
  • High-risk MDS cases had a significantly higher percentage of apoptotic CD34+ cells and anti-apoptotic survivin+ cells than controls, particularly for trisomy 8 cases. (who.int)
  • Defects in DNA double-strand break (DSB) repair signaling permit cancer cells to accumulate genomic alterations that confer their aggressive phenotype. (bmbreports.org)
  • The growth of this market is attributed to the technological advancements in image acquisition, data analysis, and storage capabilities and the need to obtain information on changes in cell morphology through high-quality images. (emailwire.com)
  • This article discusses how a combination of live-cell analysis methods deliver the required flexibility to allow these highly dynamic astrocytic models to be characterized, via quantification of their growth, motility, morphology, and functional analysis. (news-medical.net)
  • The Incucyte ® Live-Cell Analysis System delivers flexible kinetic quantification of biological phenotypes to monitor growth, motility, morphology, and cellular function. (news-medical.net)
  • Temporal monitoring of brain region astroglia revealed differences in cell growth and morphology. (news-medical.net)
  • Effects of three-dimensional culturing on osteosarcoma cells grown in a fibrous matrix: analyses of cell morphology, cell cycle, and apoptosis. (reprocell.com)
  • Have 4 connected wells, allowing for greater volume provision for highly metabolic monocultures, or active solute flow for paracrine or cell migration co-cultures. (reprocell.com)
  • Resistance to anticancer agents and apoptosis results in cancer relapse and is associated with cancer mortality. (oaepublish.com)
  • B ) Western blot analysis of the expression of NFkB-p65 and p53 in HeLa, SiHa, and ME-180 cells treated with MNBE at indicated dose for 24 h. (biomedcentral.com)
  • The re-expression of CRABP1 in CRABP1 null cells brought back the induced apoptotic activity. (wikipedia.org)
  • By assaying their anti-proliferative and anti-apoptotic effects using human promyelocytic HL-60 cells, we found that the ethanolic extract of I'm-Yunity-Too was more active in inducing cell death compared to I'm-Yunity, based on measured changes in the expression of caspase 3 and Bax. (spandidos-publications.com)
  • Subsequently, the expression of PAK3 was further confirmed in HCC cells. (jcancer.org)
  • Results: In this study, we found high expression of the HOXD9 gene transcript in glioma cell lines and human glioma tissues by quantitative real-time PCR. (123dok.net)
  • The expression of the CD86 antibody on surface of M1 cells, the function of macrophages, and the content of NO and IL-6 in the supernatant were examined. (bvsalud.org)
  • Activation-induced cytidine deaminase displays an alternative co-factor for modulating PIM1 expression in diffuse large B cell lymphoma cell lines. (cdc.gov)
  • Our results suggest that although trisomy 8 cells are in a pro-apoptotic state, they are checked by the enhanced expression of anti-apoptotic signals which provide them with their proliferative advantage. (who.int)
  • Nevertheless, no reports have disclosed whether DMC can affect the growth of human cervical cancer cells in vivo. (iiarjournals.org)
  • exhibited a growth inhibitory effect on both cell lines. (immune-source.com)
  • The first suggests that fetal gonocytes whose development into spermatogonia is blocked may undergo abnormal cell division and then invasive growth mediated by postnatal and pubertal gonadotrophin stimulation. (medscape.com)
  • Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer. (lu.se)
  • Modulation of pro and anti-apoptotic genes in cervical cancer cells after exposure to MNBE. (biomedcentral.com)
  • Role of indole curcumin in the epigenetic activation of apoptosis and cell cycle regulating genes. (cdc.gov)
  • Mesenchymal stem and stromal cells (MSCs), defined as fibroblast-like non-hematopoietic cells, have been discovered in various organs and named after their site of origin. (biomedcentral.com)
  • Clinically, grade 3B follicular lymphoma is treated like diffuse large B-cell lymphoma . (medscape.com)
  • These studies reveal potentially new therapeutic targets for recovery from anemia and regeneration of blood cells for transplantation. (ca.gov)
  • The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)
  • Overview of Bacteria Bacteria are microorganisms that have circular double-stranded DNA and (except for mycoplasmas) cell walls. (msdmanuals.com)
  • Astrocytes are a heterogeneous population of cells with distinguishing functional and morphological characteristics and are specialized to their different brain regions and locations. (news-medical.net)
  • Using this data, it is possible to see the potential that live-cell analysis provides to the research of such dynamic and heterogeneous cell types. (news-medical.net)
  • Current knowledge about the identity and function of these stem cell compartments has been largely drawn from a variety of transgenic and spontaneously mutated mouse models that are characterized by rapid rates of aging or have been used to examine regeneration from injury in the context of natural or accelerated aging. (karger.com)
  • In this review, we will present current data on lung aging and lung regeneration, with specific attention paid to stem cell-driven regeneration within the context of aging. (karger.com)
  • In multiple organs, including the lungs, age-related tissue and organ dysfunction interferes with tissue regeneration, which requires functional stem cells. (karger.com)
  • Dental follicle stem cells (DFSCs) show mesenchymal stem cell properties with the potential for alveolar bone regeneration. (biomedcentral.com)
  • Stem cell properties can be impaired by reactive oxygen species (ROS), prompting us to examine the importance of scavenging ROS for stem cell-based tissue regeneration. (biomedcentral.com)
  • The proper concentration of NAC enhances DFSC properties, especially osteogenesis, via PI3K/AKT/ROS signaling, and offers clinical potential for stem cell-based alveolar bone regeneration. (biomedcentral.com)