Cell antigens cd57. Medical search. Frequent questions

Monoclonal rearrangements (T-cell receptor γ chains and immunoglobulin heavy chains) were noted. (medscape.com)
12. T-cell receptor gammadelta T-cell leukemia with the morphology of T-cell prolymphocytic leukemia and a postthymic immunophenotype. (nih.gov)
Activation of the PI3K pathway through several membrane receptors, including T cell receptor/B cell receptor, cytokine receptors and co-stimulatory membrane molecules, lead to phosphorylation of downstream molecules, among them AKT and ribosomal protein S6 ( Figure 1 ). (frontiersin.org)
They can eradicate neoplastic cells by a targeted release of cytotoxic granules containing perforin and granzymes and/or death receptor-mediated killing [ 1 ]. (hindawi.com)
additionally, NK cells are potently activated by CD16 or Fc γ RIIIa (low-affinity Fc receptor for IgG)-dependent recognition of IgG-opsonized targets. (hindawi.com)
in such context, memory NK cells have been initially identified in healthy HCMV-seropositive individuals, mainly on the basis of high expression levels of CD94/NKG2C activating receptor and CD57 terminal differentiation marker [ 17 - 21 ]. (hindawi.com)
mediator of ADCC), CD57 (maturation marker), and NKG2C (activating receptor), along with lower expression of the inhibitory receptor NKG2A, than Siglec-9- CD56dim NK cells. (bvsalud.org)
[ 11 ] Furthermore, it has been shown that patients with CAEBV have a decrease in the T-cell receptor (TCR)-β repertoire and expanded T-cell clones in the peripheral blood. (medscape.com)
4,5 Casitas B lineage lymphoma-B (CBL-B) is an E3 ubiquitin ligase that limits T cell activation in the absence of CD28 co-stimulation following T cell receptor engagement. (bmj.com)

In anatomical pathology, CD57 (immunostaining) is similar to CD56 for use in differentiating neuroendocrine tumors from others. (wikipedia.org)

NK cell functional response to tumor cells encounter is triggered by a variety of activating receptors, some of which (e.g. (hindawi.com)
In contrast, individual NK cells express, in different combinations, several inhibitory receptors (e.g. (hindawi.com)
In addition to modulate functional responsiveness, NK cell inhibitory receptors are critical for promoting their education [ 9 ]. (hindawi.com)
A ) CML cell killing by the enhancement of memory natural killer (NK) cells and cytotoxic CD8 + T cells expressing γδTCR and a reduction of inhibitory receptors driven by dasatinib. (encyclopedia.pub)
NK cells are an heterogeneous population harboring multiple subsets that differentially expressed NK receptors such as: killer cell immunoglobulin-like receptors (KIRs), natural killer group 2 such as NKG2A, NKG2C and NKG2D, and natural cytotoxicity receptors (NCRs), for example NKp30, NKp40 or NKp46 [ 8 , 9 ]. (encyclopedia.pub)
The main activating and inhibiting NK receptors and their respective target cell ligands are shown in Figure 2 A. The NKG2C and NKG2D receptors are activating NK receptors that could detect abnormal or malignant cells by binding with HLA-E and the MIC A/B ligands, respectively. (encyclopedia.pub)
This results in cryptic T-cell epitopes, the degeneracy of T-cell receptors, and the disruption of immune tolerance [ 15 , 16 ]. (hindawi.com)

B19-specific T cells developed and maintained an activated CD38+ phenotype, with strong expression of perforin and CD57 and downregulation of CD28 and CD27. (nih.gov)
We observed consistently high frequency and phenotypically "mature" (CD27 low, CD28 low, CD45RA+) CMV-specific CD8+ T cell responses in children, including those studied in the first year of life. (biomedcentral.com)
The "phenotype" of virus-specific CD8+ T cells can be described using a few distinct subsets based on cell surface markers (CD28, CD27, CD45RA, and CD45RO). (biomedcentral.com)
Another important characteristics of immunosenscence is the exhaustion of CD95 - virgin T cells which are replaced by the progressive expansion of CD28 - T cells among both CD4 + and CD8 + subsets [ 4 ]. (oncotarget.com)
1 An increased density of OC tumor infiltrating lymphocytes (TIL), specifically memory T cells with enhanced CD28 signaling, are associated with improved survival 2 and immunotherapy response. (bmj.com)

In immunology, the CD57 antigen (CD stands for cluster of differentiation) is also known as HNK1 (human natural killer-1) or LEU7. (wikipedia.org)
This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). (wikipedia.org)
13. Phenotype of Hodgkin and Sternberg-Reed cells and expression of CD57 (LEU7) antigen. (nih.gov)

Antibodies to epithelial membrane antigen, CD57, and collagen IV are of secondary value and are used only when histologic differentiation with other neural tumors is difficult. (medscape.com)
Common variable immunodeficiency (CVID), the most common clinical primary immunodeficiency in adults, is a disorder that involves the following: (1) low levels of most or all of the immunoglobulin (Ig) classes, (2) a lack of B lymphocytes or plasma cells that are capable of producing antibodies, and (3) frequent bacterial infections. (medscape.com)
Along with highlighting these issues, we speculate that memory NK cell-based adoptive immunotherapy settings would greatly take advantage from the combination with tumor-targeting therapeutic antibodies (mAbs), as a strategy to fully unleash their clinical efficacy. (hindawi.com)
Assessment of the ability to produce functional antibodies can be obtained by measuring antibody responses to natural antigens or those antigens to which the population commonly is exposed. (medscape.com)
Isohemagglutinins are IgM antibodies to ABO blood group antigens that are polysaccharide. (medscape.com)
In children who have completed immunizations with diphtheria, pertussis, and tetanus (DPT) or Hib-conjugated vaccines, the antibody response to protein antigens can be tested in adults and older children by measuring IgG antibodies to tetanus or diphtheria toxoid and H influenzae type b (Hib) polysaccharide antigen. (medscape.com)
Approximately 80% of children have detectable antibodies to these antigens after 3 immunizations during their first year of life. (medscape.com)

Using immunohistochemistry, CD57 molecule can be demonstrated in around 10 to 20% of lymphocytes, as well as in some epithelial, neural, and chromaffin cells. (wikipedia.org)
Among lymphocytes, CD57 positive cells are typically either T cells or NK cells, and are most commonly found within the germinal centres of lymph nodes, tonsils, and the spleen. (wikipedia.org)
Individuals tested many years after infection exhibited lower frequencies of B19-specific cytotoxic T lymphocytes, typically 0.05%-0.5% of CD8+ T cells, which were perforin, CD38, and CCR7 low. (nih.gov)
Human peripheral blood lymphocytes were stained with CD8 Alexa Fluor® 488 and CD57 (clone QA17A04) Brilliant Violet 421™ (left), or mouse IgG1, κ Brilliant Violet 421™ isotype control (right). (biolegend.com)
CD57 is expressed on a subset of peripheral blood lymphocytes, including NK cells and CD8 + T cells, and is also expressed on neural cells and striated muscle. (biolegend.com)
This modification accompanies with a decrease in the absolute number of T lymphocytes (CD3 + T cells), including CD4 + T and especially CD8 + T subsets [ 3 ]. (oncotarget.com)
Blood counts revealed severe anaemia (haemoglobin 50 g/L, mean corpuscular volume 99.5 fl) with normal white blood cells (WBCs) and platelets (WBCs 6.47 × 10 9 /L, neutrophils 2.45 × 10 9 /L, lymphocytes 3.6 × 10 9 /L, platelets 245 × 10 9 /L). The absolute reticulocyte count was 1.7 × 10 9 /L. No haemorrhage, haemolysis or nutritional anaemia was found. (biomedcentral.com)
Flow cytometric analysis of the immunophenotype of the bone marrow showed that 96% of the lymphocytes were T cells, with an inversion ratio of CD4/CD8 cells. (biomedcentral.com)

Antigens, CD43" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
This graph shows the total number of publications written about "Antigens, CD43" by people in UAMS Profiles by year, and whether "Antigens, CD43" was a major or minor topic of these publications. (uams.edu)
Below are the most recent publications written about "Antigens, CD43" by people in Profiles over the past ten years. (uams.edu)

This image is part of a large collection of immunohistochemistry images of cell-surface antigens generated by the SCGAP Urologic Epithelial Stem Cells (UESC) Project. (ucsd.edu)
The cases were submitted to histopathological analysis and to CD4+, CD8+, and PD-L1+ cell determination by immunohistochemistry. (bvsalud.org)

In this condition, the immune suppression allows the escape of EBV-infected B cells and thus results in a polymorphous lymphoid proliferation composed of small B cells, plasmacytoid cells and immunoblasts. (medscape.com)
Patients with primary immune disorders are more likely to develop benign T-cell expansions of CD4-/CD8- α/β T cells than T-cell malignancies. (medscape.com)
High levels of CD57 expression amongst circulating CD8+ T cells is associated with other markers of immune ageing (immunosenescence) and may be associated with increased cancer risk in renal transplant recipients. (wikipedia.org)
Massive lymphoproliferation, bronchiectasis, increased susceptibility to bacterial and viral infections and, at a lesser extent, auto-immune manifestations and occurrence of cancer, especially B cell lymphoma, have been described for both types of APDS patients. (frontiersin.org)
In CVID, the T-cell compartment is strongly impacted, with premature arrest in thymic output, leading to T-cell exhaustion and immune dysregulation. (medscape.com)
The test has two basic parts: T-cells (ITT or Immune Tolerance Test) and "Stimulated Cytokine Testing" which provides insight as to inflammation. (betterhealthguy.com)
1 Cell Signaling and Immunity Section, Laboratory of Immune System Biology (LISB), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD. (nih.gov)
Immune evasion mechanisms, such as the PD-1/PD-L1 (programmed cell death protein 1/programmed death-ligand 1) pathway has been gaining prominence since immunotherapy with immune checkpoint inhibitors showed a positive effect on the survival of patients with different types of neoplasms. (bvsalud.org)
NK cells represent a pivotal player of innate antitumor immune responses. (hindawi.com)
Moreover, NK cells can signal to other immune cells by producing cytokines and chemokines, such as IFN- γ , TNF α , IL-6, GM-CSF, and CCL5 in response to target cells or cytokine stimulation [ 1 , 2 ]. (hindawi.com)
In particular, NK-derived IFN- γ stands as a well-recognized key immunoregulatory factor in the shaping of antitumor adaptive immune responses, by modulating dendritic cell (DC) and T cell responses [ 3 - 5 ]. (hindawi.com)
Further, NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC) is a main immune-dependent mechanism by which tumor-targeting therapeutic mAbs mediate tumor cell killing [ 6 - 8 ]. (hindawi.com)
Upon reinfection, these memory NK cells undergo secondary expansion, rapidly degranulate, and release cytokines, leading to a protective immune response, and also provide protection to newborn mice challenged with MCMV, upon adoptive transfer [ 16 ]. (hindawi.com)
Hepatitis B is not a reliable antigen for testing immune competence because of the high frequency of nonresponders in the population, particularly in persons older than 40 years. (medscape.com)
Chronic Lyme is an altogether different illness than earlier stages, mainly because of the inhibitory effect on the immune system (Bb has been demonstrated in vitro to both inhibit and kill B- and T-cells, and will decrease the count of the CD-57 subset of the natural killer cells). (dosingpdf.com)
Phenotypic and functional analyses showed that NK cells expressing the glyco-immune checkpoint Siglec-9 elicited higher ADCC than Siglec-9- NK cells. (bvsalud.org)
Alleviating the Siglec-9-mediated restriction on NK cytotoxicity may further improve NK immune surveillance and presents an opportunity to develop novel immunotherapeutic tools against SARS-CoV-2 infected cells. (bvsalud.org)
IMPORTANCE One mechanism that cancer cells use to evade natural killer cell immune surveillance is by expressing high levels of sialoglycans, which bind to Siglec-9, a glyco-immune checkpoint molecule on NK cells. (bvsalud.org)
The disruption of the finely regulated balance between virus and host immune system can result in EBV-associated lymphoproliferations of B-, T-, and NK-cell derivation, with disease manifestations generally depending on the type of EBV-infected cell and the state of host immunity Table 1 [ 17 ] and Figure 1. (medscape.com)
Dasatinib is a broad-spectrum TKI with off-target effects that give it an immunomodulatory capacity resulting in increased innate immune responses against cancerous cells and viral infected cells. (encyclopedia.pub)
Natural killer cells (NK cells), are cells from the innate immune system that show strong cytolytic function against stressed cells such as tumoral cells and virus-infected cells. (encyclopedia.pub)
APS-1 is a rare autosomal recessive or autosomal dominant disorder caused by mutations in the autoimmune regulator ( AIRE ) gene that help to reinforce immune tolerance by preventing the maturation of autoreactive T cells. (biomedcentral.com)
TLR3/4/7/8/9-related gene expression was elevated in immune cells from Black patients with SLE, and TLR7/8/9 and IFN-α phospho-signaling and cytokine responses were heightened even in immune cells from healthy Black control patients compared with White individuals. (jci.org)
TLR stimulation of healthy immune cells recapitulated the ancestry-associated SLE immunophenotypes. (jci.org)
CD3+/CD56+/CD57+/CD45+ NK-Cells (Immune-Status), Zonulin and Vitamin D3. (manumedix.com)

CD57 is increased in some disease states associated with CD4/CD8 imbalances (AIDS, autoimmune disease, viral infections, and allograft transplants). (biolegend.com)
In the search for effective vaccines against intracellular pathogens such as HIV, tuberculosis and malaria, recombinant viral vectors are increasingly being used to boost previously primed T cell responses. (ox.ac.uk)
Protection in these models is mediated by Ly49H + NK cells, which upon recognition of m157 viral antigen (Ly49H ligand) proliferate and persist in lymphoid and nonlymphoid organs. (hindawi.com)
Until we have a viral load test or the XMRV equivalent of a the CD4 count or p24 antigen used for HIV I am not sure any testing is worth it. (phoenixrising.me)
[ 12 ] To escape immunosurveillance, EBV downregulates antigen expression, establishing a stable reservoir of memory B cells that carry the viral genome, but viral antigen expression is maximally suppressed, so-called latency 0. (medscape.com)
In this study, we found that CMV+ participants had normal T cell responses after a single-dose or homologous vaccination with the viral vector chimpanzee adenovirus developed by the University of Oxford (ChAdOx1). (ox.ac.uk)
CMV seropositivity was associated with reduced induction of IFN-γ-secreting T cells in a ChAd-Modified Vaccinia Ankara (ChAd-MVA) viral vector vaccination trial. (ox.ac.uk)
Interestingly, off-target effects have been related to potential benefits such as an increased natural killer cell (NK)-mediated cytotoxic capacity against cancerous cells and viral infected cells [ 7 ] and an anti-aging capacity. (encyclopedia.pub)
B ) HIV infected cells' clearance, carrying pro-viral DNA, by dasatinib activity through the potentiation of the above cell subpopulations. (encyclopedia.pub)

Neurofibromas contain spindle-shaped cells, with fusiform or wavy comma-shaped nuclei distributed on a background of delicate connective tissue matrix. (medscape.com)
The histologic spectrum of neurofibromas includes interlacing bundles of cells with ovoid-to-spindle, often curved nuclei within a myxocollagenous background containing ropey collagen bundles. (medscape.com)
Upon review of 4‑µm sections of the lesion by light microscopy, the entire thickness of the dermis was observed to be widely infiltrated by small round monomorphic cells, with minimal cytoplasm, hyperchromatic nuclei and small nucleoli (Fig. 1A). (docksci.com)

3-beta-glucuronosyltransferase 1 (B3GAT1) is an enzyme that in humans is encoded by the B3GAT1 gene, whose enzymatic activity creates the CD57 epitope on other cell surface proteins. (wikipedia.org)
CD57, also known as HNK-1, NK-1, and Leu-7 is a 100-115 kD oligosaccharide antigenic determinant expressed on a variety of proteins, lipids, and chondroitin sulfate proteoglycans. (biolegend.com)

Surprisingly, these responses increased in magnitude over the first year post-infection despite resolution of clinical symptoms and control of viraemia, with T cell populations specific for individual epitopes comprising up to 4% of CD8+ T cells. (nih.gov)
Combined expression of perforin and CD127 revealed the existence of three populations of CD8 T-cells: CD127+perforin-, CD127-perforin- and CD127-perforin+ which were mostly CD45RA-CCR7+, CD45RA-CCR7- and CD45RA+CCR7- CD8 T-cells, respectively. (biomedcentral.com)
The overall goal of the project is to characterize and isolate epithelial stem cell populations from two urologic organs, the prostate and bladder. (ucsd.edu)
Besides their innate ability to rapidly produce effector cytokines and kill virus-infected or transformed cells, natural killer (NK) cells display a strong capability to adapt to environmental modifications and to differentiate into long-lived, hyperfunctional populations, dubbed memory or memory-like NK cells. (hindawi.com)
The perspective of NK cells as exquisitely innate effectors is challenged by the recent appreciation that NK cells can adapt their functional program in response to environmental factors, through the generation of long-lasting specialized NK cell populations with enhanced effector functions, named adaptive or memory NK cells [ 10 - 12 ]. (hindawi.com)
Doubtless, memory NK cell populations have been mostly extensively characterized in the setting of cytomegalovirus (CMV) infection. (hindawi.com)
Cellular immunity plays a crucial role in cytomegalovirus (CMV) infection and substantial populations of CMV-specific T cells accumulate throughout life. (biomedcentral.com)
However, although CMV infection occurs during childhood, relatively little is know about the typical quantity and quality of T cell responses in pediatric populations. (biomedcentral.com)
These observations are consistent with the idea that continuous or repetitive exposure to antigens slowly moulds memory T cell populations over time. (biomedcentral.com)
CMV infection induces expansion of immunosenescent T cell and NK cell populations, with these cells demonstrating lower responsiveness to activation and reduced functionality upon infection and vaccination. (ox.ac.uk)
Overall, our data suggest that although CMV infection enhances immunosenescence of T and NK populations, it does not affect antigen-specific T cell IFN-γ secretion or antibody IgG production after vaccination with the current ChAdOx1 nCoV-19 vaccination regimen, which has important implications given the widespread use of this vaccine, particularly in low- and middle-income countries with high CMV seroprevalence. (ox.ac.uk)

The lesional cells are uniformly positive for S-100 protein, signifying that they originate from neural crest-derived tissue. (medscape.com)
This assessment can also be done by measuring antibody responses following active immunization with protein or polysaccharide antigens. (medscape.com)
Assessment of responses to polysaccharide antigens is important in patients older than 18-24 months because these responses may be deficient in some patients who can respond normally to protein antigens. (medscape.com)
Protein conjugated pneumococcal vaccine elicit antibody responses that are T-cell dependent. (medscape.com)
Therefore, antibody responses should be measured to polysaccharide antigens that are not present in the protein-conjugated pneumococcal vaccine. (medscape.com)
A sialic acid-rich protein and an integral cell membrane mucin. (uams.edu)

The number and phenotype of B19-specific CD8+ T cell responses during and after acute adult infection was studied using HLA-peptide multimeric complexes. (nih.gov)
Alcohol's impact on T cells and B cells increases the risk of infections (e.g., pneumonia, HIV infection, hepatitis C virus infec- tion, and tuberculosis), impairs responses to vaccinations against such infections, exacerbates cancer risk, and interferes with delayed-type hypersensitivity. (nih.gov)
Virus-specific CD8 T-cell responses (n = 74) including CMV, EBV, Flu and HIV-1 were characterized using tetramer complexes or peptide stimulation and analyzed for proliferation capacity, expression of CD127 and perforin. (biomedcentral.com)
0.01) in virus-specific CD8 T-cell responses. (biomedcentral.com)
Here, we used polychromatic flow cytometry to investigate the phenotypic and functional profile of these vaccine-induced Mycobacterium tuberculosis (M.tb) antigen 85A-specific responses in greater detail. (ox.ac.uk)
Overall, these data strongly support the use of MVA85A in humans as a boosting agent to expand polyfunctional M.tb-specific CD4(+) T cells capable of significant secondary responses. (ox.ac.uk)
This article summarizes recent evidence in the literature on the peculiar features that render memory NK cells an attractive tool for antitumor immunotherapy, including their long-term survival and in vivo persistence, the resistance to tumor-dependent immunosuppressive microenvironment, the amplified functional responses to IgG-opsonized tumor cells, and in vitro expansion capability. (hindawi.com)
The first demonstration of antigen-specific recall responses by NK cells was in the setting of hapten-induced contact hypersensitivity, where CXCR6 + liver-derived murine NK cells could mediate antigen-specific contact hypersensitivity independently from B and T cells [ 13 , 14 ]. (hindawi.com)
We analyzed the CD8+ T cell responses to CMV, comparing these to responses in children and young. (biomedcentral.com)
This study indicates that large scale analysis of peptide specific T cell responses in infants is readily possible. (biomedcentral.com)
The robust nature of the responses observed suggests vaccine strategies aimed at priming and boosting CD8+ T cells against major pathogens (including HIV, malaria and CMV itself) could be successful in this age-group. (biomedcentral.com)
Strong virus-specific CD8+ T cell responses develop during primary infection and functional HCMV-specific CD8+ T cells are present after resolution of primary infection. (biomedcentral.com)
3 Adoptive cell therapy (ACT) utilizing ex vivo expanded TIL has demonstrated durable complete responses in several epithelial malignancies, but has shown limited clinical benefit in OC. (bmj.com)
utilized a proteonogemic approach to identify a human endogenous retrovirus-derived antigen that is immunogenic and induced antitumor CD8+ T cell responses in a patient with renal cell carcinoma. (jci.org)

Consistently, ICS on CMV-specific CD8 T-cells confirmed the lack of co-expression of perforin and IL-2, which is known to correlate with proliferation. (biomedcentral.com)
Finally, changes in antigen exposure in vitro, or in vivo during primary HIV-1 infection, modulated CD127 expression, as previously showed for perforin. (biomedcentral.com)

Analysis of participants receiving a single dose of ChAdOx1 demonstrated that T cells from CMV+ donors had a more terminally differentiated profile of CD57+PD1+CD4+ T cells and CD8+ T cells expressing less IL-2Rα (CD25) and fewer polyfunctional CD4+ T cells 14 days after vaccination. (ox.ac.uk)

11. True small lymphocytic T-cell chronic lymphocytic leukemia lacking the CD3 molecule and TCR-alpha beta on its cell surface. (nih.gov)

or as an intrinsic defect arising from impaired proliferation and maturation of myeloid progenitor cells in the BM, which is rare. (ashpublications.org)

CMV-associated T cell and NK cell terminal differentiation does not affect immunogenicity of ChAdOx1 vaccination. (ox.ac.uk)

Oligosaccharide antigenic determinants found principally on NK CELLS and T-CELLS . (nih.gov)

Subclones of these cells may acquire independent genetic changes to produce non-Hodgkin lymphomas and Hodgkin lymphoma. (medscape.com)
4. Peripheral T-cell lymphoma with Reed-Sternberg-like cells of B-cell phenotype and genotype associated with Epstein-Barr virus infection. (nih.gov)
5. Synchronous presentation of Epstein-Barr virus-associated Hodgkin's disease and adult T-cell leukemia/lymphoma (ATLL) in a patient from an endemic area of ATLL. (nih.gov)
The first case represents a systemic EBV+ T-cell lymphoma of childhood and the second case an EBV+ mucocutaneous ulcer. (medscape.com)
Histologically, MCC exhibits sheets of monomorphous small blue cells, which may be confused with other closely associated skin neoplasms, such as small cell lung cancer (SCLC), cutaneous lymphoma, melanoma, Ewing's sarcoma and rare basal cell carcinoma (3). (docksci.com)

Published data have shown prime-boost vaccination with BCG-MVA85A (modified vaccinia virus Ankara expressing antigen 85A) to be highly immunogenic in humans as measured by ex vivo IFN-gamma ELISPOT. (ox.ac.uk)

However, NKG2D and CD16 expression level on NK cells decreased with aging indicating impaired NK cell function. (oncotarget.com)

CCR7, CD45RA, PD-1 and CD57 were used to assess T-cell differentiation/exhaustion. (biomedcentral.com)
Despite significant progress in the field of NK cell-based immunotherapies, some factors including their short life span and the occurrence of a tumor-dependent functional exhaustion have limited their clinical efficacy so that strategies aimed at overcoming these limitations represent one of the main current challenges in the field. (hindawi.com)

The phenotype of CD8+ T cells in acute B19 infection has not been studied previously. (nih.gov)
The frequencies, phenotype and function CD8+ T cells for two imunodominant epitopes from pp65 were measured. (biomedcentral.com)

Alternatively antibody response to typhoid-Vi antigen can be measured following typhoid vaccine administration. (medscape.com)

So while I think the CD57 test is a useful marker from time to time, it isn't a very specific test in my opinion. (betterhealthguy.com)

We found that NK cells from hospitalized COVID-19 patients degranulate less against SARS-CoV-2 antigen-expressing cells (in direct cytolytic and antibody-dependent cell cytotoxicity [ADCC] assays) than NK cells from mild COVID-19 patients or negative controls. (bvsalud.org)
Indeed, blocking Siglec-9 significantly enhanced the ADCC-mediated NK degranulation and lysis of SARS-CoV-2-antigen-positive target cells. (bvsalud.org)

Immunohistochemically, many of the spindle cells were positive for common neural markers, with patchy staining for CD34 and epithelial membrane antigen. (medscape.com)
Membrane extract of human lymphoblastoid cell line HSB-2. (biolegend.com)
Elucidation of the multiple genetic defects have provided insight into the biology of the cell involving membrane structures, secretory vesicles, mitochondrial metabolism, ribosome biogenesis, transcriptional regulation, and cytoskeletal dynamics, as well as the risk for myelodysplasia and acute myeloid leukemia. (ashpublications.org)

Natural killer cell activity or cytokine testing might shed some light but those are expensive also. (phoenixrising.me)
Our results highlight new evidence for a continuum of change during immunologic aging and show unique data for variations of NK cells, CD8 + T cells, NKT cells, and cytokine microenvironment with human aging and health status transformation. (oncotarget.com)

Tissue section of human prostate containing adenocarcinoma that has been immunostained for the cell-surface antigen CD57. (ucsd.edu)

Neoplastic CD57 positive cells are seen in conditions as varied as large granular lymphocytic leukaemia, small-cell carcinoma, thyroid carcinoma, and neural and carcinoid tumours. (wikipedia.org)
Pure red cell aplasia (PRCA) and large granular lymphocytic leukaemia (LGLL) are very rare complications of autoimmune polyendocrine syndrome type 1 (APS1). (biomedcentral.com)

Chronic alcohol exposure also seems to and Ilhem Messaoudi, Ph.D., cause loss of peripheral B cells, while simultaneously inducing increased production is an associate professor in the of immunoglobulins. (nih.gov)
The balance between proliferation and cytotoxic capacity appears to be influenced by antigen exposure. (biomedcentral.com)
OBJECTIVE: Lower lip squamous cell carcinomas (LLSCC) could be associated with a previous history of potentially malignant oral diseases (PMOD), especially actinic cheilitis (AC), with high sun exposure being a well-described risk factor. (bvsalud.org)

4% monocytes, NK, or B cells. (bmj.com)
We observed altered whole blood frequencies and enhanced activity in CD8+ T cells, B cells, monocytes, and DCs in Black patients with more active disease. (jci.org)

HIV-positive patients may develop a spectrum of lymphoid proliferation including: reactive hyperplasia, AtLP, lesions resembling polymorphic B-cell post-transplant lymphoproliferative disorders and malignant lymphomas. (medscape.com)
Epstein-Barr virus (EBV)-associated lymphoproliferative disorders (LPDs) encompass a group of well-defined entities of B-, T-, and natural killer (NK)-cell derivation. (medscape.com)

The functional change and shift of NK, NKT and T cell subsets by aging have been widely studied. (oncotarget.com)

Immunohistochemical and molecular analysis of the intraepithelial B cells occurring in Hashimoto's disease, Sjögren's syndrome and Helicobacter pylori -associated gastritis revealed predominantly monocytoid B cells and marginal zone cells as the effector cells. (medscape.com)
These cells possessed strong effector function and intact proliferative capacity. (nih.gov)

CML is a hematopoietic progenitor cell leukemia, in which overgrown myeloid cells accumulate in bone marrow and peripheral blood [ 2 ]. (encyclopedia.pub)

Murine CMV (MCMV) infection induces immunological memory independent of T and B cells [ 15 , 16 ]. (hindawi.com)

Following 22 days of culture, DeTIL-0255 cell products were characterized by multiparameter spectral flow cytometry. (bmj.com)

Autoimmune diseases occur when a response to a self-antigen involving T cells, B cells, or autoantibodies induces injury systemically or against a specific organ [ 14 ]. (hindawi.com)

The epitopes discerned by anti-PDC-E2 and CD4 and CD8 autoreactive T cells are present in the inner lipoyl domain of PDC-E2. (hindawi.com)
A 100-fold increase in CD4 and a 10-fold increase in CD8 autoreactive T cells infiltrate into the portal tracts [ 4 , 5 ]. (hindawi.com)

IL-21 collaborates with anti-TIGIT to restore NK cell function in chronic HBV infection. (amedeo.com)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection alters the immunological profiles of natural killer (NK) cells. (bvsalud.org)
[ 6 , 7 ] During EBV primary infection, the virus undergoes lytic replication in the epithelial cells of the oropharynx subsequently infecting circulating naive B cells. (medscape.com)
[ 8 ] The latently EBV-infected B cells trigger a strong, specific primary cytotoxic response that controls the EBV infection. (medscape.com)
The quantity and the quality of the CD8+ T-cell response to EBV are critical to control the infection. (medscape.com)
[ 9 , 10 ] Patients with low numbers of EBV-specific CD8+ cells are prone to develop chronic active EBV infection (CAEBV). (medscape.com)
The potential immunomodulatory effects of dasatinib on NK cells and other innate cells and its therapeutic role against CML, HIV infection and aging ( Figure 1 ). (encyclopedia.pub)

The cover image shows H&E staining of renal cell carcinoma. (jci.org)

Interestingly enough, at the same conference, there was suggestion that CD57 can be depressed by much more than just Borrelia including Chlamydia pneumoniae , being in the middle of a strong Herxheimer or die-off reaction, and possibly even the emerging XMRV. (betterhealthguy.com)

C ) Representation of both direct killing and a potential indirect effect by boosting NK and CD8 + cells of senescent cells with dasatinib. (encyclopedia.pub)

The proportion of the HCMV-specific CD8+ T cells in the total lymphocyte pool may reach very high levels in elderly individuals [ 9 ]. (biomedcentral.com)

10. Expression of lymphoid-associated antigens on Hodgkin's and Reed-Sternberg cells of Hodgkin's disease. (nih.gov)
15. Expression of B-cell antigens by Hodgkin's and Reed-Sternberg cells. (nih.gov)
17. T-Cell Prolymphocytic Leukemia, Small Cell Variant, Possibly at the Stage of Intracytoplasmic Expression of CD3 in T-Cell Ontogenesis. (nih.gov)
Survivin expression is also highly regulated by the cell cycle and is only expressed in the G2-M phase. (survivinsignaling.com)

1. Concurrent Hodgkin's disease (mixed cellularity type) and T-cell chronic lymphocytic leukemia/prolymphocytic leukemia. (nih.gov)
2. Hodgkin/Reed-Sternberg cells and Hodgkin's disease in patients with B-cell chronic lymphocytic leukaemia: an immunohistological, molecular and clinical study of four cases suggesting a heterogeneous pathogenetic background. (nih.gov)

Acquired PRCA is an autoimmune disorder involving autoantibodies or T cell-mediated inhibition of erythropoiesis. (biomedcentral.com)

Anatomy32

Organisms9

Diseases4

Chemicals and Drugs157

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes31

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Receptor9

CD561

Receptors7

CD285

LEU73

Antibodies7

Lymphocytes8

CD433

Immunohistochemistry2

Immune25

Viral9

Nuclei3

Proteins2

Populations11

Protein6

Responses14

Perforin2

Terminally differentiated1

Molecule1

Maturation1

Terminal differentiation1

Oligosaccharide1

Lymphoma5

Immunogenic1

CD161

Exhaustion2

Phenotype2

Vaccine1

Marker1

ADCC2

Membrane3

Cytokine2

Surface1

Large granular lymphocytic leukaemia2

Exposure3

Monocytes2

Lymphoproliferative disorders2

Functional1

Effector2

Peripheral1

Murine1

Flow Cytometry1

Induces1

Autoreactive T cells2

Infection7

Renal1

XMRV1

Senescent cells1

Lymphocyte1

Expression4

Lymphocytic2

Autoantibodies1