Cell antibodies malignant cells clone cells. Medical search. Frequent questions

Human embryonal carcinoma (EC) cells are the stem cells of teratocarcinomas, and they are key components of germ cell tumors (GCTs). (sigmaaldrich.com)
The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. (origene.com)
In a clinical trial of 67 patients, scientists at the University of Nottingham found that when the vaccines were administered before and after surgery to remove malignant tumors, they helped stimulated immune cell production in up to 70 percent of patients. (cancer.org)
While low levels of CD55 occur in all cells exposed to the immune system, increased expression of the protein has been observed in multiple types of tumors, including up to 80 percent of colorectal cancers. (cancer.org)
Our aim was to establish a live cell culture to enable the understanding of the cellular processes driving the non-malignant growth of these tumors. (frontiersin.org)
Although these tumors are considered to be non-malignant, they have a high rate of proliferation and can reach large sizes before being diagnosed. (frontiersin.org)
Transplanted cells in nude mice formed subcutaneous tumors, which had histological features of squamous cell carcinoma with apparent keratinizing tendencies. (biomedcentral.com)
This study demonstrates in vitro that certain cell types from pleomorphic adenoma are able to clone and survive over a long term and develop subcutaneous tumors in nude mice. (biomedcentral.com)
Daily topical treatment with CWO induced dramatic regression of pre-malignant skin tumors and a two-fold reduction in cutaneous squamous cell carcinomas. (biorxiv.org)
SUMMARY BLURB Essential oil derived from the camphor tree acts by stimulating immune cell-dependent regression of skin tumors in a mouse model of cutaneous squamous cell carcinoma. (biorxiv.org)
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes. (lookformedical.com)
B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
The histology from the tumors carefully resembled the development patterns with extremely organized systems of elongated or spindle-shaped cells and with bigger curved cells in the interstices (Fig. (bioerc-iend.org)
In this report the role of versican was examined in adhesion of EOC spheroids and cells to peritoneal mesothelial cell monolayers in vitro as well as in formation of peritoneal tumors using an in vivo xenograft mouse model. (biomedcentral.com)
Importantly, both spheroids and cells with reduced expression of versican demonstrated significantly impaired ability to generate peritoneal tumors when injected intraperitoneally into athymic nude mice. (biomedcentral.com)
Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)
Hepatic venous outflow obstruction caused by external compression or invasion of the venous lumen is termed secondary BCS and is seen with malignant tumors or large cysts. (medscape.com)

The immunogen used for antibody production was purified actin protein from rabbit skeletal muscle. (cytoskeleton.com)

It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. (thermofisher.cn)
SM-AP1-3 cells were immunopositive for keratin only, indicating their duct-epithelial or squamous cell differentiation, while SM-AP4/5 cells were positive for both keratin and S-100 protein, indicating their myoepithelial cell differentiation. (biomedcentral.com)
however, mechanisms through which these bioactive compounds act on epithelial cells have not been identified. (biorxiv.org)
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. (lookformedical.com)
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. (lookformedical.com)
A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (lookformedical.com)
A malignant epithelial tumor with a glandular organization. (lookformedical.com)
It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA . (lookformedical.com)
Mismatch repair proteins correct King Khalid University Hospital, King mal nuclear staining in lymphocytes the insertion and deletion mutations Saud University, Riyadh, Saudi Arabia and normal epithelial or stromal cells that occur when DNA is copied be- between 2007 and 2009 were retrieved was required serving as internal con- fore cell division. (who.int)

Peripheral T cell lymphomas (PTCLs) are generally chemotherapy resistant and have a poor prognosis. (mdpi.com)
Results: A total of 12 cases of HSTCL were diagnosed during this period which accounted for 1.76% of all non-Hodgkin's lymphomas (NHLs) and 9.1% of all T-cell NHLs. (bvsalud.org)
Non-Hodgkin Lymphomas Non-Hodgkin lymphomas are a heterogeneous group of disorders involving malignant monoclonal proliferation of lymphoid cells in lymphoreticular sites, including lymph nodes, bone marrow, the. (merckmanuals.com)
It reacts with the majority of B-cells present in peripheral blood and lymphoid tissues and their derived lymphomas. (biogenex.com)
Rarely, CD20-positive T-cell lymphomas have been reported. (biogenex.com)
Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation. (lookformedical.com)
The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. (lookformedical.com)
A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. (lookformedical.com)
The area of research for our group is malignant lymphomas - all possible aspects, aiming for the improvement of the quality of life and survival of these patients. (lu.se)

The following product was used in this experiment: SOX-10 Monoclonal Antibody (ZM10), MonoMab™ from Thermo Fisher Scientific, catalog # Z2293MS. (thermofisher.com)
The following product was used in this experiment: ACSL5 Monoclonal Antibody (CL0275) from Thermo Fisher Scientific, catalog # MA5-24595, RRID AB_2637210. (thermofisher.com)
The following product was used in this experiment: FAP Recombinant Rabbit Monoclonal Antibody (ARC0634) from Thermo Fisher Scientific, catalog # MA5-35133, RRID AB_2849038. (thermofisher.cn)

FCI proved these cells to have a mature, dual-negative (CD4-/CD8-) T-cell phenotype with a gamma-delta T-cell receptor restriction. (bvsalud.org)
Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. (origene.com)
It is a reliable antibody for ascribing a B-cell phenotype in known lymphoid tissues. (biogenex.com)
Hence, the role of RI as a limiting factor for TGFβ sensitivity and the contribution of low RI levels to the malignant phenotype of GEO cells were examined. (nebraska.edu)
These findings suggest that nuclear transport of the IL-1α N-terminal component may represent a critical component in the transformation of IL-1α-generating cells in the bone marrow or the perivascular area to a malignant phenotype. (bioerc-iend.org)

A myeloma protein is an abnormal antibody (immunoglobulin) or (more often) a fragment thereof, such as an immunoglobulin light chain, that is produced in excess by an abnormal monoclonal proliferation of plasma cells, typically in multiple myeloma or Monoclonal gammopathy of undetermined significance. (wikipedia.org)
It is unclear whether intraclonal V gene diversification by somatic hypermutation, which is strictly dependent on the enzyme activation induced cytidine deaminase (AID), is restricted to the early phase of lymphoma clone expansion and later silenced, or whether it remains active throughout malignant proliferation. (bmj.com)
Overview of Plasma Cell Disorders Plasma cell disorders are a diverse group of disorders of unknown etiology characterized by Disproportionate proliferation of a single clone of B cells Presence of a structurally and electrophoretically. (merckmanuals.com)
TGFβ 1 neutralizing antibody stimulated the proliferation of RI-transfected cells but had little effect on GEO control cells, indicating that increased autocrine-negative TGFβ activity also resulted from increased RI expression. (nebraska.edu)
HP75 cells treated with overexpressed miR-543 exhibited increased cell proliferation, migration and invasion, while decreased cell apoptosis as well as expression of Cleaved caspase-3 and Cleaved caspase-8 were observed. (cancerindex.org)

Sry-related HMG-BOX gene 10, (SOX-10), a nuclear transcription factor that participates in neural crest development and in the specification and differentiation of cells of melanocytic lineage, has been recently shown to be a sensitive marker of melanoma. (thermofisher.com)
Our scientists have developed a wide array of stem cell-focused reagents and resources for many applications including flow cytometry , western blotting , ELISAs , and recombinant proteins for cell differentiation. (biolegend.com)
RUNX1 is also required for the differentiation of CD8+, Th17, and regulatory T cells. (biolegend.com)
These findings revealed that RUNX1 acts as a tumor suppressor for myeloid leukemia and is crucial for the development and terminal differentiation of several blood cell lineages 2,3 . (biolegend.com)
3-4 Anti-NGFR labels myoepithelial cells of the breast and may aid in the differentiation between benign conditions, pre-invasive neoplastic lesions and invasive malignacies of the breast. (roche.com)
It is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. (biogenex.com)
CD20 is lost upon terminal differentiation into plasma cells. (biogenex.com)
Cluster of differentiation 138 (CD138), also known as Syndecan-1, is a transmembrane glycoprotein present on the surface of B-cells during late stage differentiation. (abeomics.com)
Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)

One of these antigens, defined by monoclonal antibody TRA-1-60, can be detected in the serum of GCT patients and provides a useful complement to the established serum markers human chorionic gonadotropin and α-fetoprotein, especially in those patients without elevated serum human chorionic gonadotropin or α-fetoprotein. (sigmaaldrich.com)
Both the TRA-1-60 and TRA-1-81 monoclonal antibodies (MAB4381) recognize antigens that are associated with a pericellular matrix proteoglycan. (sigmaaldrich.com)
In general, immunohistochemical (IHC) staining techniques allow for the visualization of antigens via the sequential application of a specific antibody to the antigen (primary antibody), a secondary antibody to the primary antibody (link antibody), an enzyme complex and a chromogenic substrate with interposed washing steps. (thermofisher.com)
In general, immunohistochemical staining allows the visualization of antigens via the sequential application of a specific antibody (primary antibody) to the antigen, a secondary antibody (link antibody) to the primary antibody, an enzyme complex and a chromogenic substrate with interposed washing steps. (roche.com)
Some of these proteins are antibodies directed toward autologous IgG (rheumatoid factors) or I antigens (cold agglutinins). (merckmanuals.com)
B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
Cold agglutinin disease usually results from the production of a specific IgM antibody directed against the I/i antigens (precursors of the ABH and Lewis blood group substances) on red blood cells (RBCs). (medscape.com)
The VH genes appear to regulate not only the production of cold agglutinins, but also the formation of normal antibodies to other carbohydrate antigens, both sharing the same fundamental mechanism of production. (medscape.com)

The lu-5 antibody recognizes an epitope on the surface of cytokeratin filaments which is present in a wide range of cytokeratins, except in intermediate-size filament proteins. (biogenex.com)
Macroglobulinemia is a malignant plasma cell disorder in which B cells produce excessive amounts of IgM M-proteins. (merckmanuals.com)
Explore our solutions for multiple applications - vaccines, monoclonal antibodies, recombinant proteins, cell or gene therapy. (vwr.com)
The vaccine works by stimulating the patients' immune response to generate infection-fighting white blood cells called T cells, which in turn produce immune system proteins called cytokines that destroy cancer cells. (cancer.org)
Cells had been chosen with 800 μg/ml G418 one cell-subcloned and screened for IL-1α proteins appearance using dot-blot evaluation of cytosolic ingredients. (bioerc-iend.org)
Affinity-purified rabbit antibodies to epitopes inside the N- and C-terminal parts of the IL-1α proteins had been ready and characterized as reported (19). (bioerc-iend.org)

Note the nuclear staining of tumor cells. (thermofisher.com)
Vimentin and detyrosinated microtubules provide structural support for the extensive microtentacles observed in detached tumor cells and a mechanism to promote successful metastatic spread. (whispermovie.com)
The tumor is heterogeneous with meningeal tumor cells, mainly a mixture of fibroblast like cells, and neuroepithelial cells in a background of connective tissue. (frontiersin.org)
In addition, they had ductal arrangements or plasmacytoid appearances of tumor cells and myxoid or hyaline stromata, indicating some characteristics of pleomorphic adenoma. (biomedcentral.com)
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane. (lookformedical.com)
A cell line derived from cultured tumor cells. (lookformedical.com)

This antibody reacts with TRA-1-60 antigen that is expressed upon the surface of human tetracarcinoma stem cells (EC), human embryonic germ cells (EG) and human embryonic stem cells (ES). (sigmaaldrich.com)
We utilized modeled scFv being ISRIB a binding element of JOVI.1 antibody because so many research demonstrated this fragment was used on your behalf structure for antibody-antigen interaction research. (tuskonus.org)
The present invention relates to an anti-tyrosinase antibody for inhibiting tyrosinase and use thereof, and more particularly, to an anti-tyrosinase antibody including a heavy chain CDR and a light chain CDR of specific sequences, or an antigen-binding fragment thereof. (justia.com)
An object of the present invention is to provide an anti-tyrosinase antibody for inhibiting tyrosinase or an antigen-binding fragment thereof. (justia.com)
Another object of the present invention is to provide a fusion anti-tyrosinase antibody or an antigen-binding fragment thereof in which a TAT peptide is further bound to the anti-tyrosinase antibody or antigen-binding fragment thereof. (justia.com)
Still another object of the present invention is to provide a nucleic acid molecule encoding the antibody or antigen-binding fragment thereof, a recombinant expression vector containing the nucleic acid molecule, and a cell transformed with the recombinant expression vector. (justia.com)
Still another object of the present invention is to provide a composition for detecting a tyrosinase antigen containing the antibody or antigen-binding fragment thereof as an active ingredient. (justia.com)
Still another object of the present invention is to provide a pharmaceutical composition for preventing or treating skin pigmentation disorders or a composition for diagnosing skin pigmentation disorders containing the antibody or antigen-binding fragment thereof as an active ingredient, or a method for providing information necessary for diagnosing skin pigmentation disorders. (justia.com)
In addition, the present invention provides a fusion anti-tyrosinase antibody or an antigen-binding fragment thereof in which a TAT peptide represented by SEQ ID NO: 7 is further bound to the antibody or antigen-binding fragment thereof. (justia.com)
Prostate-specific antigen (PSA) is a protein produced by normal prostate cells. (medscape.com)

Western Blot: A previous lot of this antibody was used in WB. (sigmaaldrich.com)
Western blot of purified actin and cell extracts probed with anti-actin antibody. (cytoskeleton.com)
6 Recent studies of AID protein expression using western blot analysis showed that AID expression is largely restricted to normal and transformed GC B cells and correlates well with the expression of AID transcripts. (bmj.com)
The specificities from the affinity-purified antibodies had been verified by pre-absorption research with immunizing peptides and by Traditional western blot evaluation of stimulated individual monocyte lysates (19). (bioerc-iend.org)

Aim of the study is a comparison of expression of TCR antibodies in benign and malignant lymphoid infiltrates and their utility in borderline cases. (bvsalud.org)
Distribution and significance of nerve growth factor receptor (NGFR/ p75NTR) in normal, benign and malignant breast tissue. (roche.com)

Furthermore, spheroids with reduced expression of versican failed to disaggregate to complete monolayers when seeded atop monolayers of peritoneal mesothelial cells. (biomedcentral.com)
Mesothelial cells are specialized cells that outline the entire surface of the peritoneal cavity. (biomedcentral.com)
check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)

Unlike normal immunoglobulin antibodies, paraproteins cannot fight infection. (wikipedia.org)
Multiple Myeloma Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (merckmanuals.com)
They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (lookformedical.com)
Thus, in disease states, the finding of a clone of B cells producing this antibody may be the result of expansion of a normal clone that is specific for the production of an immunoglobulin with these properties. (medscape.com)

This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. (thermofisher.com)
The reason why a conclusive image of the invasive process in malignant gliomas is still not available is partly due to the lack of relevant models. (nature.com)
The tumor microenvironment of malignant gliomas is usually immunosuppressive,22 and this has been shown after CAR T?cell infusion.10 Immune checkpoint receptors (e.g. (campaignfornonviolentschools.org)
Checkpoint inhibitors also can be directly delivered by the adoptively transferred CAR T?cells via gene modification, which aims to reduce the adverse effects that can be caused by systemic delivery of checkpoint inhibitors.32, 34 Chitinase-IN-1 This is an additional strategy we will utilize to further liberate the function of IL-13R2 CAR T?cells in immunotherapy of malignant gliomas. (campaignfornonviolentschools.org)

AAN02 is a mouse monoclonal antibody against actin protein. (cytoskeleton.com)
Actin is the major protein of the microfilament cytoskeletal system and is a key protein in various cell motility processes. (cytoskeleton.com)
The primary antibody is intended for laboratory professional use in the detection of the corresponding protein in formalin-fixed, paraffin-embedded tissue stained in manual qualitative immunohistochemistry (IHC) testing. (thermofisher.com)
In sentinel node, SOX-10 is positive in metastatic melanomas and nodal capsular nevus but not in dendritic cells, which usually express S100 protein. (thermofisher.com)
Rb , or retinoblastoma protein, is a key regulator of the cell cycle, particularly during the transition from the G1 to S phases. (biolegend.com)
Within the brain, the protein is involved in the development of specialized cells that process smell. (biolegend.com)
7 Several studies analysing AID expression and mutation patterns in V gene rearrangements in various B cell non-HLs showed that, although somatic hypermutation activity is strictly dependent on AID, the expression of this protein does not necessarily indicate ongoing somatic hypermutation. (bmj.com)
Full length human recombinant protein of human AKT2 (NP_001617) produced in HEK293T cell. (origene.com)
The MI15 monoclonal antibody specifically binds to CD138 (Syndecan-1), an 85-92 kDa single chain transmembrane protein, which is strongly expressed on multiple-myeloma-derived cell lines and malignant plasma cell populations. (bdbiosciences.com)
This is the first vaccine shown to stimulate TNF-alpha an immune-system protein that is very effective at killing cancer cells," said Lindy Durrant, senior author of the study and professor of cancer immunotherapy at the university. (cancer.org)
105AD7 is structurally similar to CD55, a protein that attaches to sugar molecules and is overexpressed in colorectal cancer cells, protecting them from attack by the body's immune system. (cancer.org)
The CD20, which is a 33 kDa protein that traverses the cell membrane, initially expresses on pre B-cells and retains on mature B-cells. (biogenex.com)
Protein activation and expression were analysed by western blotting, deoxyribonucleoside triphosphate levels by HPLC, ribonucleotide reductase activity by 14 C-cytidine incorporation into nascent DNA and cell-cycle distribution by FACS. (nature.com)

Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
Early patch-stage cutaneous T-cell lymphoma. (medscape.com)
Related articles include Cutaneous B-Cell Lymphoma and Cutaneous Pseudolymphoma . (medscape.com)
Among the changes to CTCL classification were the addition of primary cutaneous acral CD8 + T-cell lymphoma as a new provisional entity. (medscape.com)
Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
Background: Hepatosplenic T-cell lymphoma (HSTCL) is a rare fatal T-cell neoplasm with unique clinical and laboratory features. (bvsalud.org)
Aims and Objectives: The study was aimed to study the prevalence and clinic-pathological spectrum of this rare variant of T cell lymphoma in the Indian subcontinent. (bvsalud.org)
INTRODUCTION: Cutaneous T-cell lymphoid infiltrate can represent reactive lesion or a malignant T-cell lymphoma. (bvsalud.org)
The lymphocytic and histiocytic (L&H) cells of lymphocyte predominant Hodgkin lymphoma (HL) originate from germinal centre B cells and carry mutated V gene rearrangements, usually with intraclonal diversity. (bmj.com)
ALK+ Large B-Cell Lymphoma (LBCL) commonly stains positively for CD138, but not for CD20 and CD79a. (abeomics.com)
Anti-CD138 reacts positively with HHV8-associated primary effusion lymphoma that lack B-cell markers. (abeomics.com)
Lymphoma b cell. (lookformedical.com)
A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. (lookformedical.com)
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)

ProductData": { "ID": "RTD001065", "ProductType": "Others", "BrandName": "Nerve Growth Factor Receptor (NGFR) (MRQ-21) Mouse Monoclonal Antibody", "ProductNameAddition": "", "RegulatoryDisclaimer1": "For in vitro diagnostic use. (roche.com)
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Immunohistochemistry: A previous lot of this antibody was used in IH. (sigmaaldrich.com)
11 To clarify this issue for lymphocyte predominant HL we quantitatively examined the expression of AID in the L&H cells of six patients with lymphocyte predominant HL at the transcription level, because suitable antibodies for immunohistochemistry are not yet available. (bmj.com)

slides with a complete solution of antibodies, ancillary reagents, and detection systems. (leicabiosystems.com)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents. (lookformedical.com)

antibody, followed by staining with DyLight™ 488 conjugated secondary IgG antibody (green). (biolegend.com)
The cells were fixed, permeabilized, blocked and then stained with primary antibody, and Alexa Fluor® 594 conjugated secondary IgG (Cat. (biolegend.com)
The histological features of squamous cell carcinoma from the transplanted cell systems in nude mice might suggest a secondary onset of malignancy from a pre-existing benign adenoma. (biomedcentral.com)

Lymphoid cells concerned with humoral immunity. (lookformedical.com)
20] It is found on cold agglutinin-producing malignant lymphoid cells in the bone marrow in persons with lymphoproliferative disorders, on a small proportion of normal lymphoid cells, and in the spleen of a 15-week-old fetus. (medscape.com)

This gene functions in mediating fatty acid-induced glioma cell growth. (thermofisher.com)
Vimentin expression in human malignant glioma cells depends on cellular density, algorithms of drug delivery and chemo/radio treatment. (whispermovie.com)
Based on these results, we are designing a pre-clinical trial to evaluate the security of canine IL-13R2 CAR T?cells in doggie with spontaneous IL-13R2-positive glioma, which will help to Chitinase-IN-1 inform a human clinical trial design for glioblastoma using humanized scFv-based IL-13R2 targeting CAR T?cells. (campaignfornonviolentschools.org)

An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. (lookformedical.com)

When someone has myeloma, a malignant clone, a rogue plasma cell, reproduces in an uncontrolled fashion, resulting in overproduction of the specific antibody the original cell was generated to produce. (wikipedia.org)

The capability of these cells to differentiate depends on the stem cell type, the regulation of gene expression by various transcription factors and interaction with the stem cell niche 1,4 . (biolegend.com)
RUNX1 regulates CD4 gene transcription during multiple stages of T cell development and represses the CD4 gene in CD4-CD8- (double negative) T cells. (biolegend.com)
Aberrant expression of T-cell markers is not always applicable and T-cell receptor (TCR) gene rearrangement is not always accessible and diagnosis in borderline cases can be challenging. (bvsalud.org)
1 Analysis of V gene rearrangements in single L&H cells revealed the presence of somatic mutations with intraclonal diversity in functional monoclonal V gene rearrangements, in line with a GC B cell origin. (bmj.com)
Intraclonal diversity in V gene rearrangements as a result of active somatic hypermutation is a typical feature of GC B cells. (bmj.com)

Monoclonal Anti-MUC1 (mouse IgG1 isotype) is derived from the hybridoma 1D1 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with semi-purified MUC1 from pleural effusion of a breast cancer patient. (sigmaaldrich.com)

Therefore, to improve the performance of this promising strategy in the clinical treatment of GBMs, it is necessary to generate a fully humanized, highly specific, scFv-based IL-13R2 CAR T?cell and demonstrate its function both and in clinically relevant pre-clinical models of GBM. (campaignfornonviolentschools.org)

METHODS: Representative cases of reactive and malignant lymphoproliferations were collected. (bvsalud.org)
CD138 is also a useful marker for identifying and enumerating benign, reactive, or malignant plasma cells from the bone marrow biopsy samples. (abeomics.com)

Blood serum paraprotein levels of more than 30 g/L is diagnostic of smouldering myeloma, an intermediate in a spectrum of step-wise progressive diseases termed plasma cell dyscrasias. (wikipedia.org)
Detection of paraprotein in serum of less than 30 g/L is classified as monoclonal gammopathy of undetermined significance in cases where clonal plasma cells constitute less than 10% on bone marrow biopsy and there is no myeloma-related organ or tissue impairment. (wikipedia.org)
VWR provides the cell culture community with access to the most reliable supply of exceptional quality Fetal Bovine Serum: VWR Life Science Seradigm. (vwr.com)
Serum antinuclear antibodies, extractible nuclear antibod- signs. (cdc.gov)

Of the nine samples of small cell carcinoma, categorized as atypical, suspicious for carcinoma, three (33%) were categorized as suspicious for small cell carcinoma, while the others were not further classified, due to limitations of cellular preservation. (cytojournal.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

Moreover, relapse is normally found however the autologous stem cell transplant may improve progression-free success (PFS)26. (tuskonus.org)

Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Background Information", "Value": "Nerve growth factor receptor (NGFR), also known as p75NTR, is a 75-kDa glycoprotein member of the tumor necrosis factor (TNF) receptor family essential for embryonic development of the peripheral nervous system. (roche.com)
Anti-CD20 can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood, and B cell localization in tissues. (biogenex.com)

Chronic Lymphocytic Leukemia (CLL) Chronic lymphocytic leukemia (CLL) is characterized by progressive accumulation of phenotypically mature malignant B lymphocytes. (merckmanuals.com)
It is also expressed on pre-B cells, immature B cells, and plasma cells, but not on mature circulating B-lymphocytes. (bdbiosciences.com)
She smoked heavily, did not abuse alcohol or injection x 106 lymphocytes/L with no malignant cells. (cdc.gov)
A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)

Human malignant melanoma stained with anti-SOX-10 antibody using peroxidase-conjugate and DAB chromogen. (thermofisher.com)
1,2 NGFR has been shown to be a reliable adjunct marker for melanoma, specifically desmoplastic and spindle cell variants. (roche.com)
P75 nerve growth factor receptor staining is superior to S100 in identifying spindle cell and desmoplastic melanoma. (roche.com)
Specificity: KBA.62 is a novel anti-melanoma antibody. (scytek.com)

This Anti-TRA-1-60 Antibody, clone TRA-1-60 is validated for use in WB, FC, IF, IP, IC for the detection of TRA-1-60. (sigmaaldrich.com)
This antibody is recommended for detection of actin in a broad spectrum of species such as human, mouse, rat, and bovine. (cytoskeleton.com)
The low level of positivity for external positive controls is designed to ensure detection of subtle changes in the primary antibody sensitivity from instability or problems with the staining methodology. (thermofisher.com)
10: Does routine preparation of multiple ThinPrep ® and cell block slides improve the detection of malignancy in effusion fluid? (cytojournal.com)
This antibody is optimally diluted to be compatible with VENTANA detection kits and BenchMark IHC/ISH instruments. (roche.com)
From the abstract: 'Multicancer early detection (MCED) blood tests can detect a cancer signal from circulating cell-free DNA (cfDNA). (cdc.gov)

Antibody is used with formalin-fixed and paraffin-embedded sections. (thermofisher.com)

This antibody was developed for use in flow cytometry. (bdbiosciences.com)

Monoclonal antibody MI15 blocks the binding of clone B-B4 but not clone DL-101 (other anti-syndecan-1 antibodies) by flow cytometric analysis. (bdbiosciences.com)

As a result, there is a characteristic normal distribution of these antibodies in the blood by molecular weight. (wikipedia.org)
The framework of JOVI.1 antibody was also generated prior to the binding mode was predicted using molecular docking with an antibody mode. (tuskonus.org)
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. (lookformedical.com)
We describe here the molecular cloning of IC1. (embl.de)

1,2 In normal tissue, NGFR is expressed in neural crest derived cells, lymphoid follicular dendritic cells seen in lymph nodes and tonsils, and myoepithelial cells of the breast, prostate, and salivary gland as well as basal epithelium of the respiratory system. (roche.com)

However, the essential specificity and interaction from the clone to TRBC1 are unknown. (tuskonus.org)

A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. (lookformedical.com)
Malignant neoplasm arising from the epithelium of the BRONCHI. (lookformedical.com)

Squamous cell carcinomas, adenocarcinomas, and small cell carcinomas of the urinary bladder are rare and account for less than 5, 2, and 0.5% of all bladder carcinomas, respectively. (cytojournal.com)
Between the period of 1983 and 2009, there were a total of 25 cases of small cell carcinoma, 20 of squamous carcinoma, and 10 of adenocarcinoma, wherein prediagnosis urine cytology was available. (cytojournal.com)
There were eight cases (12 samples) of small cell carcinoma, four cases (6 samples) of squamous cell carcinoma and four cases (5 samples) of adenocarcinoma. (cytojournal.com)
In the squamous cell carcinoma subgroup, the samples with 'atypical, suspicious for carcinoma' diagnoses did not show any keratinization and were interpreted as atypical urothelial cells. (cytojournal.com)
None of the samples of small cell carcinoma had a false negative diagnosis on cytology, while only one case of squamous cell carcinoma was diagnosed as negative. (cytojournal.com)
Carcinoma squamous cell. (lookformedical.com)

citation needed] Myeloma is a malignancy of plasma cells. (wikipedia.org)

They are preferentially expressed by a variety of adenocarcinomas, including breast, prostate, ovarian and pancreatic carcinomas as well as malignant plasma cells of multiple myelomas. (sigmaaldrich.com)
In our previous study, we proposed a concept of focal carcinomas in pleomorphic adenoma which is an advanced stage of accumulated atypical cells with P53 over-expressions as an initial stage or a latent form of apparent carcinomas secondarily arising in pleomorphic adenoma [ 3 ]. (biomedcentral.com)

An isotype control should be used at the same concentration as the antibody of interest. (bdbiosciences.com)

Immunohistochemical study of microsatellite instability was done with antibodies to hMSH2 and hMSH6 . (who.int)

Muc1 might serve as a candidate for single chain antibody mediated targeted therapy in MUC1 expressing cancers. (sigmaaldrich.com)
Recently, CAR T cells for cancers treatment have already been translated to T cell ISRIB malignancies6 successfully. (tuskonus.org)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

It is still poorly understood how and which benign pleomorphic adenoma cells transform into its malignant form, carcinoma ex pleomorphic adenoma. (biomedcentral.com)
A human colon carcinoma cell line, designated GEO, is marginally responsive to TGFβ and expresses a low level of RI mRNA relative to colon carcinoma cells, which are highly responsive to TGFβ. (nebraska.edu)

cells and potentially induce severe adverse Rabbit Polyclonal to OR2A5/2A14 effects. (campaignfornonviolentschools.org)

However, it is difficult to capture the complexity of transcript isoform variance using these libraries, and large cDNA sequences are often difficult to clone into size-limited viral expression vectors. (cdc.gov)

Moreover, it reacts positively against junctional nevus cells but not intradermal nevi, and against fetal melanocytes but not normal adult melanocytes. (scytek.com)

RUNX1-deficient mice fail to generate hematopoietic stem cells. (biolegend.com)
It is also expressed on some non-hematopoietic cells, including embryonic mesenchymal cells, vascular smooth muscle cells, endothelial and neural cells. (bdbiosciences.com)
Recent studies have shown the K562 blasts are multipotential, hematopoietic malignant cells that spontaneously differentiate into recognisable progenitors of the erythrocyte, granulocyte and monocytic series. (nkmaxbio.com)

Taken together these data suggest that versican regulates the development of peritoneal metastasis originating from cells and spheroids. (biomedcentral.com)

British scientists have developed a vaccine that stimulates colorectal cancer patients' immune systems to fight malignant cells. (cancer.org)
The antibody contained in the vaccine, called 105AD7, was cloned from a patient who survived seven years with liver metastases from colorectal cancer, Durrant explained. (cancer.org)

Cells grown in vitro from neoplastic tissue. (lookformedical.com)

The antibody has been shown to recognize α-skeletal, α-cardiac, α-smooth muscle, β-cytoplasmic, γ-smooth muscle and γ- cytoplasmic actin isotypes (Fig. 1) and has broad species cross-reactivity. (cytoskeleton.com)
Reactivity has also been noted with Reed-Sternberg cells in cases of Hodgkin's disease, particularly of lymphocyte predominant type. (biogenex.com)

SOX-10 is moderately to strongly positive in desmoplastic or spindle cell melanomas, which is usually negative for HMB-45, Melan-A or even S-100. (thermofisher.com)
SM-AP1 to SM-AP3 showed polygonal cell shapes while SM-AP4 and SM-AP5 were spindle-shaped. (biomedcentral.com)
results in malignant transformation to a spindle cell-type tumor. (bioerc-iend.org)

Immunoprecipitation: A previous lot of this antibody was used in IP. (sigmaaldrich.com)

AIMS: Several types of TCR antibodies are currently available with limited knowledge of their expression in different cutaneous lymphoid infiltrates. (bvsalud.org)

Avantor® can help equip your life sciences lab with the products, equipment, and supplies you need - whether you work in cell biology, genomics, proteomics, or other fields. (vwr.com)

These cells, among other functions, provide a protective barrier against invading pathogens and secrete surfactant molecules to provide a non-adhesive surface. (biomedcentral.com)

Apoptosis was measured by Hoechst 33258/propidium iodide double staining of nuclear chromatin and the formation of gaps into the lymphendothelial barrier in a three-dimensional co-culture model consisting of MCF-7 tumour cell spheroids and human lymphendothelial monolayers. (nature.com)
In cultured keratinocytes, CWO stimulated calcium signaling, resulting in calcineurin-dependent activation of nuclear factor of activated T cells (NFAT). (biorxiv.org)

Enrichment of cancer stem cells was observed in neurospheres by FACS using CD133 antibody and RT-PCR. (frontiersin.org)

It further inhibited cell-cycle progression in the G1 phase by four different mechanisms: rapid downregulation of cyclin D1, induction of Chk2 with simultaneous downregulation of Cdc25A, induction of the Cdk-inhibitor p21 Cip/Waf and inhibition of ribonucleotide reductase activity resulting in reduced dCTP and dTTP levels. (nature.com)
These results indicate that low RI expression can be a limiting factor for response to exogenous TGFβ, as well as TGFβ autocrine-negative activity, and that reduction of RI expression can contribute to malignant progression. (nebraska.edu)

No immunoreactivity is seen with murine EC, EG or ES cells. (sigmaaldrich.com)
Cold agglutinins commonly have variable heavy-chain regions encoded by VH, with a distinct idiotype identified by the 9G4 rat murine monoclonal antibody. (medscape.com)

We have established five cell systems from a benign pleomorphic adenoma of the parotid gland of a 61-year-old woman. (biomedcentral.com)
We established and characterized five cell systems (designated as SM-AP1 to SM-AP5) from a benign pleomorphic adenoma of the parotid gland. (biomedcentral.com)
Although pathologists in their daily services of surgical pathology had recognized such singular atypical cells in pleomorphic adenomas, these atypical cells were not always regarded as evidence or the source for malignant transformation [ 4 - 6 ]. (biomedcentral.com)
The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. (lookformedical.com)

Anatomy36

Organisms12

Diseases25

Chemicals and Drugs94

Analytical, Diagnostic and Therapeutic Techniques and Equipment43

Phenomena and Processes52

Disciplines and Occupations1

Information Science3

Health Care4

Tumors20

Immunogen1

Epithelial11

Lymphomas10

Thermo Fisher Sci3

Phenotype5

Proliferation5

Differentiation9

Antigens8

Proteins6

Tumor cells6

Antigen10

Western blot4

Benign and malignant2

Mesothelial cells3

Immunoglobulin4

Gliomas4

Protein13

Lymphoma18

Mouse monoclonal3

Immunohistochemistry2

Reagents2

Secondary3

Lymphoid cells2

Glioma3

Highly malignant1

Specific antibody1

Gene5

IgG11

Clinical1

Reactive2

Serum4

Cellular2

Autologous1

Peripheral2

Lymphocytes4

Melanoma4

Detection6

Formalin-fixed1

Flow cytometry1

MI151

Molecular4

Lymph1

Specificity1

Neoplasm2

Squamous6

Malignancy1

Carcinomas2

Isotype1

Immunohistochemical1

Cancers3

Carcinoma2

Rabbit1

CDNA1

Reacts1

Hematopoietic3

Metastasis1

Colorectal cancer2

Vitro1

Reactivity2

Spindle3

Immunoprecipitation1

AIMS1

Biology1

Molecules1

Nuclear2

FACS1

Progression2

Murine2

Pleomorphic4