Cell and molecular. Medical search. Frequent questions

Somatic Cell and Molecular Genetics was a peer-reviewed scientific journal in the fields of cell biology and molecular genetics. (wikipedia.org)
The journal was established in 1975 as Somatic Cell Genetics. (wikipedia.org)
The journal expanded scope to encompass the increased development of molecular genetics and changed its name to reflect this with the tenth volume January 1984 edition. (wikipedia.org)
Somatic Cell and Molecular Genetics is fully indexed in Index Medicus, MEDLINE, and PubMed. (wikipedia.org)
Possibilities include "Molecular Genetics " (BIOL2540) or topical seminar offerings in genetics and/or genomics. (brown.edu)
Advanced knowledge of molecular genetics and microbial cell biology through case studies of model systems of molecular mycology (yeasts and filamentous fungi). (uni-goettingen.de)
The mission of the Molecular Cell Biology, Genetics and Development Track is to educate and train students to make paradigm-shifting discoveries in a diverse range of disciplines, including molecular biology, cell biology, genomics and quantitative biology, stem cells and developmental biology, cancer biology, and human disease modeling. (yale.edu)
In addition to MCGD having phenomenal administrative staff, the faculty are determined to provide a strong foundation in molecular cell biology and genetics by introducing us to the latest research and techniques in our core courses. (yale.edu)

However, FOXO-mediated mechanisms can also support the survival of cancer and other dysfunctional cells, thereby complicating the link between FOXOs and lifespan extension. (nature.com)
These adaptive molecular and structural mechanisms increase respiration to maintain basic processes specific to cell types and tissues. (nature.com)
the FCG track provides advanced training in computational and systems biology, and the MBoA track provides training in the molecular mechanisms of aging. (brown.edu)
While studies have deciphered the genetic and immunological mechanisms of some AID, the pathogenesis and molecular or environmental drivers of most AID are still unclear. (news-medical.net)
Tailored and more effective treatment options can be developed by better understanding the pathogenic molecular mechanisms of AID using scRNA-seq. (news-medical.net)
The review also explored a combination of single-cell sequencing technologies and multi-dimensional and multi-molecular analysis approaches in targeting the molecular mechanisms of AID, which would provide a basis for examining the pathogenesis and molecular markers of autoinflammatory and autoimmune disorders in the future. (news-medical.net)
Dr. Piri's research is aimed toward understanding the molecular mechanisms leading to retinal ganglion cells (RGC) death in glaucoma. (uclahealth.org)
The objective of this study was to provide a generalized critique for the role of mesenchymal stem cell therapy in ischemic stroke injury, its underlying mechanisms, and constraints on its preclinical and clinical applications. (hindawi.com)
Herein, we presented an overview of a previously published work regarding the role of stem cell therapy in ischemic stroke and its underlying molecular mechanisms. (hindawi.com)
In conclusion, a reduction in beta cell mass is a key component of diabetes mellitus and the molecular mechanisms underlying beta cell loss remain to be clarified. (europa.eu)
An understanding of the molecular mechanisms that govern stem cell fate and the identification of specific stem cell markers is of fundamental significance in cell and developmental biology. (eurostemcell.org)
However, the molecular mechanisms of how ES cells are differentiated remain much less understood. (utexas.edu)
Thus, the aim of this work is to carry out a review of the literature on the role of bacterial endotoxin in the etiology of periapical lesions, its mechanism of action, and to elucidate molecular mechanisms involved in endotoxin's recognition by the immune system and cell activation. (bvsalud.org)
Therefore, the objective of this study is to carry out a review of the literature on the role of bacterial endotoxin in the etiology of periapical lesions, as well as to elucidate molecular mechanisms involved in its recognition by the immune system and in cell activation. (bvsalud.org)
Integrated analysis of single-cell RNA-seq and bulk RNA-seq to unravel the molecular mechanisms underlying the immune microenvironment in the development of intestinal-type gastric cancer. (bvsalud.org)

This is mediated by cytokines and other mediators released by the activated immune cells invading the islets, which activate secondary pathways of cell death in the target beta cells. (europa.eu)
This Specific Targeted Research Project (STREP) aims to utilise functional genomics to identify pathways responsible for the reduction of beta cell mass in diabetes, and use this knowledge to define targets for intervention to preserve beta cell mass. (europa.eu)
These findings validate the proposed systems biology approach to understand the molecular pathways underlying decreased beta cell mass in diabetes mellitus and have provided important information for the development of novel alternatives to preserve beta cell mass in early diabetes. (europa.eu)
ES cells have been an invaluable resource for advancing fundamental understanding of global transcriptional and epigenetic regulations, signaling pathways, and noncoding RNA in mammalian systems. (utexas.edu)
3,8-9 In fact, there is a great interest in the understanding of its structure and its mechanism of action, particularly of the molecular pathways involved in its recognition and cellular signaling, 10-15 as well as the forms of its inactivation 3,16 . (bvsalud.org)
In this study, we used a new, small molecule, a selective inhibitor of DNA-PKcs, 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026), as a probe to analyze the molecular events and pathways in hydroquinone-induced DNA DSB repair and apoptosis. (cdc.gov)

The B.S. degree in Molecular and Cell Biology places emphasis on the molecular biology and biochemistry that control cell functions. (wwu.edu)
Your submission to Molecular Biology, Cell Biology, and Biochemistry Program (MCBB) has been sent. (petersons.com)

For the Applied Mathematics track, in the first semester training in statistical analysis of complex datasets will begin with "Statistical Inference" (APMA 1650) and will continue in the second semester with "Inference in Genomics and Molecular Biology" (APMA 1080). (brown.edu)
To achieve this ambitious goal, we have established a consortium of leading European experts from seven European countries in the fields of pancreatic beta cell diabetes research, functional genomics and bioinformatics. (europa.eu)
In the research part we will deal with the basic principles of the innate immune defense used to control tumors and viral infections with a focus on NK and NK/T cells, including analysis of NK receptor genomics/epigenetics, gene polymorphisms/disease linkage, differentiation of hitherto unrecognized NK cell subpopulations and novel ligands for NK receptors exposed by tumor and/or virally infected cells. (europa.eu)

Being able to image the cell volume in high resolution should allow researchers to better observe the internal dynamics of cells, such as the trafficking of signalling proteins (the cell's communication) in response to encounters with pathogens. (edu.au)
This peptide-MHC complex signals through the T cell receptor and its associated proteins. (nih.gov)
Signal 2 is provided by costimulatory proteins, especially the B7 proteins (CD80 and CD86), which are recognized by the co-receptor protein CD28 on the surface of the T cell. (nih.gov)
The expression of B7 proteins on an antigen-presenting cell is induced by pathogens during the innate response to an infection. (nih.gov)
Effector T cells act back to promote the expression of B7 proteins on antigen-presenting cells, creating a positive feedback loop that amplifies the T cell response. (nih.gov)
Scientists believe that the study of genes that encode the proteins for molecular motors will help solve the mysteries of evolution. (icr.org)
The good news is that we identified several proteins called transcription factors that these cells require to handle the challenges of migrating and thriving at metastatic sites, and we may be able to design new therapies that target these transcription factors. (sciencedaily.com)
Many bacteria and unicellular algae have light-driven pumps in their cell membranes: proteins that change shape when exposed to photons such that they can transport charged atoms in or out of the cell. (scitechdaily.com)
This is a basic course in flow cytometry, which covers various applications of the technique, such as analysis of extracellular and intracellular proteins, analysis of cell viability and cell proliferation, detection of proteins in solution and cell sorting. (lu.se)

In the future, keratinocytes produced from pluripotent stem cells could be an alternative to adult stem cells in certain reconstructed tissue bio-engineering applications. (cea.fr)

This gives you the freedom to focus on research that most interests you while being able to explore varied, supporting aspects of cellular and molecular biology. (bristol.ac.uk)

To do this, breast cancer cells gain a cellular skeleton protein dubbed vimentin, which enhances the migratory ability of so-called mesenchymal cells, a cell type typically found in bones and bone marrow that moves around and makes new cells. (sciencedaily.com)

The theme of your project is chosen in conjunction with internationally-renowned research groups from the Schools of Biochemistry and Cell Biology, Microbiology, and the Department of Anatomy & Neuroscience. (gradireland.com)

We will discuss the key features of cancer biology, such as deregulated cell cycle progression, growth, invasion and metastasis. (york.ac.uk)

In this Tools of the Trade article, Sarah Paramore (from the Devenport and Nelson labs) discusses the use of mouse strains carrying genomic alterations in PCP genes and how they can increase our understanding of mammalian planar cell polarity. (nature.com)
Together, this comprehensive delineation of mammalian cell differentiation trajectories in vivo represents a baseline for understanding the effects of gene mutations during development, as well as a roadmap for the optimization of in vitro differentiation protocols for regenerative medicine. (nih.gov)
This has catalyzed research in both early embryogenesis as a model system for mammalian development as well as regenerative medicine as a renewable source of unspecialized cells which can be converted into nearly any cell type required by a patient. (utexas.edu)

Research and project orientated acquisition of biomolecular, genetic, biochemical and cell biological techniques in the involved departments in small groups. (uni-goettingen.de)
The authors discussed the current understanding of the immune microenvironment, novel pathogenic immune cells, transcriptional signatures, molecular heterogeneity, and the genetic variation in these systemic AID based on scRNA-seq combined with other spatiotemporal transcriptomic techniques. (news-medical.net)
As an initial step in identifying potential factors responsible for RGC apoptosis, Dr. Piri's laboratory is analyzing gene expression patterns that are altered in glaucomatous retinas using DNA microarrays and proteomic technologies, as well as conventional molecular biology, biochemistry and genetic methods. (uclahealth.org)
In this review, we offer our recommendations on the optimal testing strategies for detecting genetic alterations in thyroid cancer that have the potential to be targeted by molecular therapy. (nih.gov)
The project will support anti-tumor and anti-viral therapies by developing novel technology for NK cell generation from cord blood stem cells for NK cell infusions in patients, by genetic engineering of NK cells and by using NK receptors and their ligands to develop novel reagents for amplifying anti-tumor and -viral activities of NK/T cells. (europa.eu)

If a T cell receives signal 1 without signal 2, it may undergo apoptosis or become altered so that it can no longer be activated, even if it later receives both signals ( Figure 24-62 ). (nih.gov)
It has been established that RGCs die by apoptosis in glaucoma, but the exact pathway from death stimulus to cell death is not understood. (uclahealth.org)
Gene and protein expression studies may lead to a better understanding of the regulatory events involved in RGC apoptosis, and provide molecular targets for the development of new therapeutic agents with neuroprotective effects in order to prevent or delay the loss of ganglion cells in glaucoma. (uclahealth.org)
Inhibition of DNA-dependent protein kinase catalytic subunit by small molecule inhibitor NU7026 sensitizes human leukemic K562 cells to benzene metabolite-induced apoptosis. (cdc.gov)
Taken together, the findings reveal a central role of DNA-PKcs in hydroquinone-induced hematotoxicity in which it coordinates DNA DSB repair, cell cycle progression, and apoptosis to regulate the response to hydroquinone-induced DNA damage. (cdc.gov)

The MCB curriculum is aimed at students with a primary interest in molecular biology, cell biology, developmental biology, proteomics and/or biochemistry. (brown.edu)
The seminar courses are designed to offer students in-depth training in specific topics in molecular biology, cell biology, developmental biology, proteomics and biochemistry. (brown.edu)
Avril Rincon has been selected by the Department of Molecular, Cell & Developmental Biology as the 2021-2022 Kristen Hanson Memorial Scholarship recipient. (ucla.edu)
Across the animal kingdom, gastrulation represents a key developmental event during which embryonic pluripotent cells diversify into lineage-specific precursors that will generate the adult organism. (nih.gov)
We develop students to be independent, imaginative and careful scientists, preparing our graduates to be the next generation of molecular cell biologists, geneticists, and developmental biologists in a broad array of science-related careers. (yale.edu)

The study has shown that manipulation of KLF4 expression is also suitable for these cells, as reducing its expression in keratinocytes derived from embryonic stem cells (ESC) improves their proliferation capacity and their ability to reconstruct skin. (cea.fr)
We construct a molecular map of cellular differentiation from pluripotency towards all major embryonic lineages, and explore the complex events involved in the convergence of visceral and primitive streak-derived endoderm. (nih.gov)
Piriev N, Yamashita CK, Shih J, Farber DB: Expression of functionally active cone photoreceptor cGMP-PDE o' subunit in chinese humster ovary, 293 human embryonic kidney and Y79 retinoblastoma cells. (uclahealth.org)
This poster provides an overview of distinct embryonic and adult stem-cell types and the stem-cell markers that have been used to identify stem cells and cancer-stem-cell-enriched populations. (eurostemcell.org)
Mouse embryonic stem (ES) cells are pluripotent cells, meaning that they can give rise to all tissues in the body. (utexas.edu)

If you are interested in joining one of the world's leading research intensive universities to deliver significant and transformative advances in a wide range of areas of Structural and Chemical Biology, Cell Proliferation and Differentiation, Regulation of gene expression or Channels, Receptors and Signalling, please see our current vacancies below. (le.ac.uk)
Differentiation is a complex process involving actions of ES cell core factors, lineage specific regulators, epigenetic modifications, and chromatin remodelers. (utexas.edu)
Thus, a single reporter-based screen would have been inappropriate to identify novel regulators of ES cell differentiation. (utexas.edu)
Our signature-based screen established several categories of genes based on their comparative functions during the differentiation of ES cells. (utexas.edu)
This will be a valuable information for other researchers interested in ES cell differentiation from various perspectives. (utexas.edu)
We have identified two novel regulators of ES cell differentiation - Yap1 and Rbpj. (utexas.edu)
Conversely, we found that Yap1 is essential for proper ES cell differentiation. (utexas.edu)
Repressive role of Rbpj is also required for proper differentiation of ES cells by silencing core factors. (utexas.edu)

Here we report the transcriptional profiles of 116,312 single cells from mouse embryos collected at nine sequential time points ranging from 6.5 to 8.5 days post-fertilization. (nih.gov)
Furthermore, we use single-cell profiling to show that Tal1 -/- chimeric embryos display defects in early mesoderm diversification, and we thus demonstrate how combining temporal and transcriptional information can illuminate gene function. (nih.gov)

Furthermore, many immunomodulatory drugs result in adverse reactions such as malignancy and infections, and the cell and tissue heterogeneity in patients sometimes results in no health improvements. (news-medical.net)
Cell heterogeneity is also assessed by analyzing the differential gene expression. (news-medical.net)
Our analysis of the IGC single- cell atlas together with bulk transcriptome data contributes to understanding TME heterogeneity at the molecular level during IGC development and provides insights for elucidating the mechanism of IGC and discovering novel targets for precise therapy . (bvsalud.org)

The teaching and research activities of the Department of Molecular and Cell Biology (MCB) concern the molecular structures and processes of cellular life and their roles in the function, reproduction, and development of living organisms. (berkeley.edu)
Students interested in molecular research and graduate study in the basic sciences might consider the B.S. degree. (drake.edu)
Research progress of single-cell transcriptome sequencing in autoimmune diseases and autoinflammatory disease: A review. (news-medical.net)
Research indicates that AID is associated with lowered or absent tolerance of B and T cells , and human leukocyte antigen sites are generally connected with increased susceptibility to AID. (news-medical.net)
2 Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. (nih.gov)
The research, using mouse models and human tissues, could pave the way for developing new treatments that target such molecular variations. (sciencedaily.com)
We have long needed new treatment targets and options for triple negative breast cancers," says Andrew Ewald, Ph.D., the Virginia DeAcetis Professor in Basic Science Research and Director, Department of Cell Biology at the Johns Hopkins University School of Medicine and co-leader of the Cancer Invasion and Metastasis Program at the Johns Hopkins Kimmel Cancer Center. (sciencedaily.com)
For the current study, the research team looked at molecular differences between initial, or primary, triple-negative breast cancer sites and areas where it spread, or metastatic sites, among three different types of cells: mouse models, human cancers implanted into mice and samples of both primary and metastatic tissues taken from eight patients treated at The Johns Hopkins Hospital. (sciencedaily.com)
More specifically, Ewald and Johns Hopkins postdoctoral fellow Eloïse Grasset, Ph.D., and others on the research team found several unique properties in the cells of mice engineered to have the mouse-version of triple negative breast cancers, and mice implanted with tumors from people with triple negative breast cancer. (sciencedaily.com)
Our understanding and treatment of human disease is increasingly dependent on research undertaken by cell biologists. (bristol.ac.uk)
We offer you the invaluable opportunity of joining an exceptional scientific environment at the beginning of your research career, helping you to develop the intellectual and practical knowledge required to study modern cell biology and, importantly, how to apply and translate this to human disease. (bristol.ac.uk)
Our MSc Molecular Cell Biology with Bioinnovation (MSc MCB) programme is a unique multidisciplinary master's programme aimed at highly motivated students with an interest in biomedical research and its applications. (gradireland.com)
The remaining 40 credits are attached to the Molecular Cell Biology Research Dissertation (ML6001). (gradireland.com)
Our program emphasizes interdisciplinary training and collaborative research using cutting-edge molecular technologies and experimental systems to address fundamental and innovative biological questions using a range of approaches, from super-resolution imaging to genomic and proteomic analyses. (yale.edu)
Jörg Standfuss, co-author of the study who built up a PSI team dedicated to creating such molecular movies, adds: "This combination enables first-class biological research as would only be possible at very few other places in the world beside PSI. (scitechdaily.com)

Thank you for sharing this Molecular Pharmacology article. (aspetjournals.org)
Message Body (Your Name) thought you would be interested in this article in Molecular Pharmacology. (aspetjournals.org)

Although no routine laboratory studies are helpful for nevoid basal cell carcinoma syndrome (NBCCS), some studies may potentially aid in the diagnosis. (medscape.com)
Molecular testing is available to confirm the diagnosis in patients with atypical findings or possibly for prenatal diagnosis. (medscape.com)

The module will include the importance of cancer stem cells and the tumour microenvironment, the spread of cancer and therapeutic advances. (york.ac.uk)
For this study, single-cell RNA-seq data related to IGC were downloaded from the GEO database, and immune cells of the tumor microenvironment (TME) were annotated using R software . (bvsalud.org)

Although some immune-related biomarkers can identify individuals at risk to develop T1D, the process by which the beta cells are destroyed is not well understood. (europa.eu)

Trajectory inference is used to understand transitional states and asynchronous changes in the biological function of the cells. (news-medical.net)

Photoactive chloride pumping through the cell membrane captured by time-resolved serial crystallography: Chloride ions (green spheres) are transported across the cell membrane by the NmHR chloride pump (pink). (scitechdaily.com)
Pink crystals reveal the mechanism of chloride transport over the cell membrane: Using time-resolved serial crystallography, the pink NmHR crystals revealed ion binding sites in the chloride transporter and pumping dynamics after photoactivation. (scitechdaily.com)

The approach could help test hypotheses about how atypical function of the brain's immune cells contributes to autism. (the-scientist.com)
Practical parts will be performed on human immune cells in our cell lab, and samples will be analysed on BD FACS Canto and BD FACS Aria II instruments. (lu.se)
Changes in the proportion of immune cells and altered cell-to-cell interactions were explored at different disease stages using R software , with a focus on plasma cells . (bvsalud.org)
The results indicated that for precancerous lesions, interactions between immune cells were mainly dominated by chemokines to stimulate the infiltration and activation of immune cells . (bvsalud.org)

As Director, I welcome you to the interdepartmental graduate program in Molecular Biology, Cell Biology & Biochemistry (MCBB), which offers both PhD and MA degrees. (bu.edu)
The MCBB Program provides students with a strong foundation in several current scientific fields, all focused on molecular sciences. (bu.edu)

Thus, we attempted to present an overview of previously published reports to evaluate the progress and provide molecular basis of mesenchymal stem cells (MSCs) therapy and its application in preclinical and clinical settings, which could aid in designing an effective regenerative therapeutic strategy in the future. (hindawi.com)

Signal 1 is provided by a foreign peptide bound to an MHC protein on the surface of the presenting cell. (nih.gov)
Molecular motors are important features of eukaryotic cells that are formed by a variety of protein types. (icr.org)
The lethal nature of this type of cancer is marked by the fact that its cells lack molecular flags on its surface that connect with the hormones estrogen and progesterone and a cancer growth-promoting protein called Her2-neu. (sciencedaily.com)
Triple negative breast cancer cells also gain survival advantages by producing a protein called E-cadherin, typically found in epithelial cells that line the ducts and coverings of organs and frequently renew themselves. (sciencedaily.com)
Dr Matthias Soller has secured a BBSRC grant on RNA splicing using Drosophila Down Syndrome Cell Adhesion Molecule as a model membrane protein. (birmingham.ac.uk)
For the first time, a molecular movie has captured in detail the process of an anion transported across the cell membrane by a light-fuelled protein pump. (scitechdaily.com)
Among others, it possesses a rhodopsin protein in its cell membrane which transports chloride anions from outside the cell to its inside. (scitechdaily.com)
As the study has revealed, the chloride anion is attracted by a positively charged patch of the rhodopsin protein in Nonlabens marinus' cell membrane. (scitechdaily.com)
We have previously reported that exposure of workers to benzene and to benzene metabolite hydroquinone in cultured cells induced DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to mediate the cellular response to DNA double strand break (DSB) caused by DNA-damaging metabolites. (cdc.gov)

The Scholarship will consist of financial support for a single year of tuition at the Honours level, if taken within a laboratory of the Molecular and Cell Biology Academic Group. (edu.au)
I am intending to commence Honours (year 4) within a laboratory of the Molecular and Cell Biology Academic Group. (edu.au)
intend to commence an Honours program within a laboratory of the Molecular and Cell Biology Academic Group. (edu.au)

You are expected to attend seminars in the Schools of Biochemistry and Cell Biology and the Department of Anatomy & Neuroscience as advertised. (gradireland.com)

Details on course content and modules can be found in the Postgraduate College Calendar (Molecular Cell Biology with Bioinnovation). (gradireland.com)

Cell cycle analysis by flow cytometry with HeLa cells indicated that 1 and 2 induced cell cycle arrest in the G2/M phase while 3 induced arrest in the G0/G1 phase leading to cell death. (rsc.org)
Flow cytometry is widely used for analysis of immune cell characteristics as well as for sorting of pure cell populations. (lu.se)

H 2 O 2 + R′ H 2 → R′ + 2H 2 O. This type of oxidative reaction is particularly important in liver and kidney cells, where the peroxisomes detoxify various toxic molecules that enter the bloodstream. (nih.gov)
As the authors report in Nature Communications , the 3D focus-lock mechanism enables imaging beyond the surface of the cell to provide a 3D view of distinct molecules inside a cell, including living cells. (edu.au)
To look more closely at molecules involved in hybrid EMT states, the scientists sought the help of Elana Fertig, Ph.D., division director and associate director of quantitative sciences and co-director of the Convergence Institute at the Johns Hopkins Kimmel Cancer Center, to track the molecular patterns of individual cells in cell assays that model invasion out of the primary tumor and formation of a colony in a metastatic site. (sciencedaily.com)

Peroxisomes are found in all eucaryotic cells. (nih.gov)
One hypothesis is that peroxisomes are a vestige of an ancient organelle that performed all the oxygen metabolism in the primitive ancestors of eucaryotic cells. (nih.gov)

The signaling events initiated by the binding of peptide-MHC complexes to T cell receptors (signal 1). (nih.gov)
Molecular docking studies indicated that all three complexes primarily bind to HSA in subdomain IIA with amino acid residues such as Arg218 and Lys199 which are located at the entrance of Sudlow's site I. The in vitro cytotoxicities of complexes 1-3 against HeLa cells showed promising anticancer activity (IC 50 = 3.5, 3.9 and 16.9 μM for 1 , 2 and 3 , respectively). (rsc.org)

3. Centre for the Study of Stem Cells (CECS), Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I Stem), 91100 Corbeil Essonne, France. (cea.fr)

ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
Viscous solutions accelerate the migration of tumor cells and may enable metastasis, according to a new study. (the-scientist.com)

A CEA-Jacob team has just published a paper in which it demonstrates the central role of the transcription factor KLF4 in regulating the proliferation of epidermal stem cells and their ability to regenerate this tissue. (cea.fr)
Taken together, our study provides a detailed functional and molecular characterization of HSCs at different phases of regeneration and identifies a gene set associated with the transition from proliferation to quiescence. (lu.se)

The tissues used in scRNA-seq for AID are primarily derived from blood or peripheral blood cells or diseased liver, synovial fluid, kidney, or intestine, tissue. (news-medical.net)
The scientists found that when triple negative breast cancer cells invade other tissues on their way to another part of the body, they gain two cellular properties: better movement and survival. (sciencedaily.com)
In order to understand gene function in a cellular and tissue/organism context, and to fully appreciate a cellular process, it is vital to examine its dynamics in living cells, tissues and organisms. (bristol.ac.uk)
T2D results from a reduced ability of the pancreatic beta cells to secrete enough insulin to stimulate glucose utilisation by peripheral tissues. (europa.eu)
Gram-negative bacteria not only have different factors of virulence and generate products and sub-products that are toxic to apical and periapical tissues, but also contain endotoxin in the outer membrane of their cell wall. (bvsalud.org)

Researchers explore the idea that molecular patterns in individual cells could underlie the development of a left and a right in animals. (the-scientist.com)

Researchers from UNSW Medicine & Health and UNSW Science have developed a new method to visualise living cells in three-dimensional clarity - at the subnanometre scale - by 'focus-locking' on samples while they are being recorded. (edu.au)
Researchers visualize the beautiful inner world of cells! (the-scientist.com)
Researchers use imaging to show how actin fibers tilt and then swirl to create left-right asymmetry in the cell. (the-scientist.com)

The main problem with this idea is that, not only does no such creature exist, but eukaryotes also contain molecular similarities to both bacteria and archaea-prokaryotes that are found in completely separate domains of cellular life. (icr.org)
However, effective dose and appropriate time of MSCs delivery are the main challenges in the clinical translation of stem cell therapy. (hindawi.com)

This expansion phase involves a risk: it may be accompanied by a quantitative loss or degradation of stem cells, leading to a loss of regenerative potential. (cea.fr)

This ulcerated nodule of localized primary cutaneous CD30+ anaplastic large cell lymphoma is relatively nonspecific in appearance. (medscape.com)
PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)
This work has been extended to other types of cells of interest for cutaneous cell therapy. (cea.fr)

Living cells can now be visualised in three-dimensional molecular detail, enabling new insights to cellular structure and behaviour. (edu.au)
Further insights into its molecular events indicate that the acute phase takes almost 2 weeks to complete after the incidence of the injury [ 15 ]. (hindawi.com)

An insight into the biology of ischemic stroke indicates that a stream of molecular events initiates instantly after the onset of ischemic stroke, such as oxidative stress, increased level of intracellular calcium, excitotoxicity, and inflammation which results in apoptotic or necrotic neuronal cell death [ 12 - 14 ]. (hindawi.com)

Failure to execute these regulatory responses causes cell damage and inflammation or senescence, compromising cell survival and the ability to adapt to energetically demanding conditions. (nature.com)

2. University of Évry, University of Paris-Saclay, INSERM U861, Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (I-Stem), 91100 Corbeil Essonne, France. (cea.fr)
However, despite having the promising outcome of preclinical studies, the clinical application of stem cell therapy remained elusive due to little or no progress in clinical trials. (hindawi.com)
The recent decade has seen encouraging outcomes of mesenchymal stem cell therapy that holds promise to alleviate the burden of neurological disorders Moreover, initial study data of preclinical trials have also indicated the effectiveness, tolerance, and safety of MSC-based therapy [ 10 ]. (hindawi.com)
We aim to provide the basis for establishing a future study to promote the clinical translation of stem cell therapy in ischemic brain diseases. (hindawi.com)

Stressed cells can form hollow actin bridges to neighbors to get help, but the virus may hijack these tiny tunnels for its own purposes, a study suggests. (the-scientist.com)
Learn more about Cell and Molecular Biology on our Biology Field of Study page. (evergreen.edu)
The bad news from our study is that cells from metastatic sites are super optimized for migration and resisting treatment," says Ewald. (sciencedaily.com)
Why study dynamic molecular cell biology? (bristol.ac.uk)

This is one mechanism by which a T cell can become tolerant to self antigens. (nih.gov)
The combined actions of signal 1 and signal 2 stimulate the T cell to proliferate and begin to differentiate into an effector cell by a curiously indirect mechanism. (nih.gov)

It was shown that these mice fail to increase their beta cell mass in response to a high fat diet and develop diabetes. (europa.eu)
Our technical expertise include lentiviral vectors, transgenic mice and stem cells cultures. (lu.se)

It consists of a balance of core and advanced classes directed toward graduate work in the molecular sciences. (drake.edu)

Genetics8

Mechanisms15

Pathways6

Biology and biochemistry2

Genomics3

Proteins9

Pluripotent stem1

Cellular and molecular biology1

Mesenchymal cells1

Microbiology1

Cancer Biology1

Mammalian3

Genetic5

Apoptosis5

Developmental5

Embryonic5

Differentiation8

Transcriptional2

Heterogeneity3

Research15

Pharmacology2

Diagnosis2

Microenvironment2

Biomarkers1

Biological1

Crystallography2

Immune cells4

MCBB2

Provide molecular1

Protein9

Laboratory3

Neuroscience1

Content1

Flow cytometry2

Molecules3

Eucaryotic2

Complexes2

Centre1

Tumor cells2

Proliferation2

Tissues5

Patterns1

Researchers3

Main2

Quantitative1

Cutaneous3

Insights2

Intracellular1

Regulatory1

Stem Cell Th4

Study4

Mechanism2

Mice2

Sciences1