• Medulloblastoma, large cell/anaplastic. (cancer.gov)
  • Context Undifferentiated (spindle cell) carcinomas of the pancreas are rare anaplastic variants of pancreatic ductal adenocarcinoma with a frequency of 2% of pancreatic exocrine tumors. (imedpub.com)
  • Detailed histopathological classification of tumors from a cohort of patients ( n = 87) composed mainly of children entered into the International Society of Pediatric Oncology (SIOP)/United Kingdom Children's Cancer Study Group PNET3 trial ( n = 65), included identification of the large cell/anaplastic phenotype. (aacrjournals.org)
  • The large cell/anaplastic phenotype, which was present in 20% of medulloblastomas, emerged as an independent prognostic indicator. (aacrjournals.org)
  • Loss of 17p13.3 (38% of medulloblastomas) was found across all of the histopathological variants, whereas MYCC / MYCN amplification (6%/8% of medulloblastomas) was significantly associated with the large cell/anaplastic phenotype. (aacrjournals.org)
  • Together with metastatic tumor at presentation, the large cell/anaplastic phenotype, 17p13.3 loss, or high-frequency MYC amplification defined a high-risk group of children whose outcome was significantly ( P = 0.0002) poorer than a low-risk group without these tumor characteristics. (aacrjournals.org)
  • When the specimen is predominantly cystic, Type II PPB is differentiated from Type I PPB by thickened or plaque-like areas composed of an overgrowth of rhabdomyosarcomatous, spindle cell sarcomatous, or blastematous elements. (ppbregistry.org)
  • Of three patients with lung-biopsy-proven benign lymphocytic angiitis and granulomatosis, two experienced complete resolution of their disease from therapy with chlorambucil and one underwent spontaneous remission with no drug therapy after lung biopsy and removal of a benign spindle cell thymoma. (biomedsearch.com)
  • Pathology grading systems classify the microscopic cell appearance abnormality and deviations in their rate of growth with the goal of predicting developments at tissue level (see also the 4 major histological changes in dysplasia). (wikipedia.org)
  • While the exact cause of sarcopenia is unknown, it may be induced by a combination of a gradual failure in the satellite cells which help to regenerate skeletal muscle fibers, and a decrease in sensitivity to or the availability of critical secreted growth factors which are necessary to maintain muscle mass and satellite cell survival. (wikipedia.org)
  • By contrast, hypertrophy is what occurs, for example, to skeletal muscle cells during weight training and steroid use and is simply an increase in the size of the cells. (wikipedia.org)
  • The histology of a tumor, or the condition of its cells as seen under a microscope, affects the recovery rate. (chp.edu)
  • Metastatic patterns were analyzed using cluster analysis in patients with epidermal growth factor receptor (EGFR) mutation-positive lung adenocarcinoma, those with small cell lung cancer (SCLC), and those with squamous cell lung cancer (SqCLC). (bvsalud.org)
  • RESULTS: Epidermal growth factor-mutated adenocarcinoma, small cell lung cancer, and squamous cell lung cancer had different 'metastatic patterns', survival, and unfavorable prognostic factors, respectively. (bvsalud.org)
  • Since a cancer cell usually looks different than a normal cell, the type of thyroid cancer is determined by microscopic examination of the thyroid cells found in the nodule (neck lump) or growth. (endocrineweb.com)
  • these cells have little discernible cytoplasm and mitotic figures are numerous. (ppbregistry.org)
  • ABSTRACT: A light and fluorescent microscopy study of sternal and femoral bone marrow, taken from young Swiss mice exposed for up to 280 days to elevated levels of NaF in drinking water, revealed morphologic abnormalities in cell structure and mitotic figure formation in immature leukocytes. (slweb.org)
  • Gloghini A, Colombatti A, Bressan G, Carbone A. Basement membrane components in lymphoid follicles: immunohistochemical demonstration and relationship to the follicular dendritic cell network. (springer.com)
  • Thus, blastemal cells likely need special factors and interactions to retain their phenotype. (nature.com)
  • To make an accurate diagnosis of thyroid cancer, the thyroid cells will need to be closely examined. (endocrineweb.com)
  • WT as an embryonal tumor is thought to arise from renal precursor cells, which explains the histological heterogeneity reminiscent of embryonal kidney development. (nature.com)
  • An example of a normal hyperplastic response would be the growth and multiplication of milk-secreting glandular cells in the breast as a response to pregnancy , thus preparing for future breast feeding . (wikipedia.org)
  • Especially the high-risk blastemal WT subtype is not represented by the few primary cell lines established until now. (nature.com)
  • The key reactions of this metabolic pathway are the dehydroxylation of the phenolic hydroxy group, i.e., conversion of urolithin M5 to urolithin M6, and successive conversion of urolithin M6 to urolithin C. By testing the effects of various electron-transferring compounds on the dehydroxylation reactions, methylviologen was found to effectively support the dehydroxylation catalyzed by the cell free extracts. (bvsalud.org)
  • This antibody has been shown to stain keratin subtypes present in the prostate only in basal cells. (biomedsearch.com)