• Laser assisted Optical Rotational Cell Analyser (L.O.R.C.A). A new instrument for measurement of variuous structural hemorheological parameters. (edu.pl)
  • Determination of blood cells aggregability and deformability is performed directly by means of aggregometers and appropiate filters and indirectly using rheological techniques with advanced mathematical models of blood viscoelasticity. (edu.pl)
  • The hypothesis of the present research is as follows: Platelets activated by high shear stress secrete substances, which can affect hemorheological characteristics to promote RBC aggregation. (iospress.com)
  • Another member of the TREM family, The Triggering receptor expressed on myeloid cells Like Transcript-1 (TLT-1) is exclusively expressed in platelets and promotes platelet aggregation. (sigmaaldrich.com)
  • It has been shown that cell membranes, liposomes, and static activated platelets can dissociate pentameric or native C-reactive protein (nCRP) into the monomeric and highly pro-inflammatory form via binding to phosphocholine groups on lysophosphatidylcholine. (frontiersin.org)
  • Mechanistic studies indicated that LD/LP tumor cells induced aggregation of homologous platelets, whereas HD/HP B16a cells failed to induce significant platelet aggregation. (rti.org)
  • Aggregation of homologous platelets correlated positively with lung-colonizing ability. (rti.org)
  • BM-MSCs and LA-MSCs inhibited activation and aggregation of stimulated platelets independent of the agonist used. (biomedcentral.com)
  • Platelets, also called thrombocytes (thromb- + -cyte, "blood clot cell"), are a component of blood whose function (along with the coagulation factors) is to stop bleeding by clumping and clotting blood vessel injuries. (wikipedia.org)
  • Platelets have no cell nucleus: they are fragments of cytoplasm that are derived from the megakaryocytes of the bone marrow, and then enter the circulation. (wikipedia.org)
  • Platelets are found only in mammals, whereas in other animals (e.g. birds, amphibians) thrombocytes circulate as intact mononuclear cells. (wikipedia.org)
  • On a stained blood smear, platelets appear as dark purple spots, about 20% the diameter of red blood cells. (wikipedia.org)
  • The ratio of platelets to red blood cells in a healthy adult ranges from 1:10 to 1:20. (wikipedia.org)
  • They are the functional equivalents of platelets, but circulate as intact mononuclear cells, and are not simply cytoplasmic fragments of bone marrow megakaryocytes. (wikipedia.org)
  • PrP C depletion caused an increase in both the number of cells containing granules and the number of apoptotic cells. (biologists.org)
  • Consistent with the increase in Htt aggregation, PrP C depletion caused an decrease in proteasome activity and a decrease in the activities of cellular defense enzymes compared with control cells whereas reactive oxygen species (ROS) increased more than threefold. (biologists.org)
  • Depletion of endogenous PrP C in non-neuronal Caco-2 and HT-29 cells did not affect ROS levels or proteasome activity suggesting that only in neuronal cells does PrP C confer protection against Htt toxicity. (biologists.org)
  • A depletion mechanism has been proposed for dextran-mediated RBC aggregation and its applicability to high molecular weights has been recently documented. (ntu.edu.sg)
  • In part of this study, the depletion layers around the cell surface for various polymer sizes (40kDa-28MDa), ionic strengths (5 and 15mM) and polymer concentrations (≤0.9g/dl) are measured by means of electrophoretic mobility. (ntu.edu.sg)
  • These results agree with the concept of polymer depletion near the cell surface and support a depletion mechanism for dextran-mediated red cell aggregation. (ntu.edu.sg)
  • Our findings provide important new insights into polymer-RBC interactions and confirm the concept of depletion mechanism for RBC aggregation which may help in understanding how cellular properties control in-vivo RBC interactions. (ntu.edu.sg)
  • Attractive energy between two RBCs is modelled by a depletion interaction theory and used for simulating aggregation of two cells. (elsevier.com)
  • Based upon the depletion model for polymer-induced aggregation, these findings suggest that poloxamer 188 acts by penetrating the depletion layer near the glycocalyx, thereby reducing the osmotic gradient between the intercellular gap and the suspending medium. (elsevier.com)
  • We suggest that, as found in colloidal dispersions, the presence of a non-adsorbing polymer in the form of the exopolysaccharide succinoglycan drives aggregation of S. meliloti by depletion attraction. (royalsocietypublishing.org)
  • We have discovered a new and specific cell-killing mechanism mediated by the selective uptake of the antitumor drug 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3, Edelfosine) into lipid rafts of tumor cells, followed by its coaggregation with Fas death receptor (also known as APO-1 or CD95) and recruitment of apoptotic molecules into Fas-enriched rafts. (csic.es)
  • This mechanism represents the first selective activation of Fas in tumor cells. (csic.es)
  • The discovery of aggregation inhibitors and the elucidation of their mechanism of action are key in the quest to mitigate the toxic consequences of amyloid formation. (springer.com)
  • However, the mechanism that facilitates aggregation and implantation of EOC cells is poorly understood. (aacrjournals.org)
  • Demonstrated a completely novel mechanism of stem cell-to-immune system communication that works via the horizontal exchange of functional IFN-g/Ifngr1 complexes delivered via stem cell exosomes. (news-medical.net)
  • Regardless of the specific mechanism(s) of action, poloxamers appear to offer interesting approaches for future basic science and clinical studies, and thus the possibility for greater insight into RBC aggregation. (elsevier.com)
  • Succinoglycan purified from cultures was applied to different concentrations of cells, and observation of the phase behaviour showed that the limiting polymer concentration for aggregation and phase separation to occur decreased with increasing cell concentration, suggesting a 'crowding mechanism' was occurring. (royalsocietypublishing.org)
  • Unlike for cell lysis-dependent release, the oral streptococci appear to induce eDNA release by a novel mechanism. (pubmedcentralcanada.ca)
  • In the instant invention, HMG-CoA reductase inhibitors are found to upregulate endothelial cell Nitric Oxide Synthase activity through a mechanism other than preventing the formation of oxidative-LDL. (google.com)
  • Richard Rudhale( epub protein aggregation in bacteria 1415-1476),' 17 Ecclesiastical Law Journal 58( 2015). (sitnews.org)
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  • As the in vitro aggregation of amino-terminal mutant huntingtin fragment offers a ready assay to identify small compounds that interfere with the conformation of the polyglutamine tract, we have identified a number of aggregation inhibitors, and tested whether these are also capable of reversing a phenotype caused by endogenous expression of mutant huntingtin in a striatal cell line from the \(Hdh^{Q111/Q111}\) knock-in mouse. (harvard.edu)
  • Conclusions: At least some compounds identified as aggregation inhibitors also prevent a neuronal cellular phenotype caused by full-length mutant huntingtin, suggesting that in vitro fragment aggregation can act as a proxy for monitoring the disease-producing conformational property in HD. (harvard.edu)
  • As a result, HMG-CoA reductase inhibitors are useful in treating or preventing conditions that result from the abnormally low expression and/or activity of endothelial cell Nitric Oxide Synthase. (google.com)
  • However, although RBC aggregation certainly affects low-shear blood viscosity, its effects on in vivo flow resistance remain uncertain. (spiedigitallibrary.org)
  • Finally, we demonstrated in vivo transfer of α-syn between host cells and grafted dopaminergic neurons in mice overexpressing human α-syn. (nih.gov)
  • Prolonged culture resulted in a 10-fold decrease in the incidence of B16a lung colonies, whereas passage in vivo for 150 days did not affect lung colony formation by tumor cells isolated from enzymatic dispersates by centrifugal elutriation. (rti.org)
  • Mer regulates macrophage activation, promotes apoptotic cell engulfment, and supports platelet aggregation and clot stability in vivo. (bloodjournal.org)
  • Mice lacking either Gas6 or Mer protein have impaired platelet aggregation in vitro and diminished clot stability in vivo. (bloodjournal.org)
  • 1 , 4 For example, increased RBC aggregation, elevated blood viscosity and the ratio of hematocrit (Hct) to blood viscosity (HVR, an index to the oxygen transport potential of blood) have been shown to significantly affect in vivo microcirculatory flow dynamics. (haematologica.org)
  • Here we present an in vivo study of MitoPQ in the vertebrate zebrafish model in the context of Parkinson's disease (PD), and in a human cell model of Huntington's disease (HD). (gla.ac.uk)
  • We show that MitoPQ is 100-fold more potent than non-targeted paraquat in both cells and in zebrafish in vivo. (gla.ac.uk)
  • Endothelium-derived relaxing factor inhibits platelet aggregation in human whole blood in vitro and in the rat in vivo. (semanticscholar.org)
  • Recently, another group of compounds, aminobisphosphonates such as pamidronate, was demonstrated to be capable of activating the primary human γδ T cells both in vitro and in vivo ( 18 , 19 ). (jimmunol.org)
  • What percentage of transplanted neural stem/precursor cells (NPCs) survive in vivo and why? (news-medical.net)
  • Candidates will be designed to deliver in vivo treatments to the right places in the body, and optimized to target the cells involved in the respective diseases efficiently and specifically, according to the agency and Foundation. (genengnews.com)
  • Overall the data in this study confirms that in vivo protein aggregation depends on molecular recognition and suggests that rationally tuning the kinetic competition between folding and aggregation might result in highly active, inclusion bodies. (biomedcentral.com)
  • The mAb also caused homotypic aggregation of E710.2.3, which was inhibited by cytochalasin B, trifluoperazine, a combination of sodium azide and 2-deoxyglucose, EDTA, incubation at 4°C, or treatment with paraformaldehyde. (jimmunol.org)
  • We found that SAP prevents cell death induced by mutant TTR, while several other molecules that are also known to decorate amyloid fibrils do not have such effect. (diva-portal.org)
  • The different capability of phthalocyanines and meso-tetra ( N -methyl-4-pyridyl) porphine tetrachloride ([H 2 PrTPCl 4 ]) to modulate αS aggregation in vitro was reproduced in cell-based models of αS aggregation, demonstrating unequivocally that the modulation exerted by these compounds on amyloid assembly is a direct consequence of their interaction with the target protein. (springer.com)
  • We have previously characterized a number of small molecule organic compounds that prevent the aggregation of the β-amyloid peptide and its neurotoxicity in hippocampal neuronal cultures. (conicyt.cl)
  • We have now evaluated the effects of such compounds on amyloid precursor protein (APP) accumulation in the CTb immortalized cell line derived from the cerebral cortex of a trisomy 16 mouse, an animal model of Down's syndrome. (conicyt.cl)
  • Mutations that remove the part of LRP4 that anchors it to the cell membrane weaken this complex and thus reduce the development of neuromuscular junctions in mice, especially if the animals also lack amyloid precursor protein. (elifesciences.org)
  • Membrane interaction in aggregating cells of Dictyostelium discoideum can be blocked by univalent antibodies directed against specific membrane sites. (rupress.org)
  • Patterns of cell assembly in the presence of antibodies show that selective blockage of these membrane sites abolishes the preference for end-to-end association which is typical for aggregating cells. (rupress.org)
  • The target sites of aggregation-inhibiting antibodies are suggested to be identical or associated with the molecular units of the cell membrane that mediate cell-to-cell contacts during aggregation. (rupress.org)
  • We find that Dlgh1 translocates to the immune synapse and lipid rafts in response to T cell receptor (TCR)/CD28 engagement and that LckSH3-mediated interactions with Dlgh1 control its membrane targeting. (rupress.org)
  • In diffusely growing cells, cellulose microfibrils are synthesized by plasma-membrane-localized cellulose synthase (CESA) complexes. (plantphysiol.org)
  • Walnut extract reduced Aβ-mediated cell death assessed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) reduction, and release of lactate dehydrogenase (membrane damage), DNA damage (apoptosis) and generation of ROS in a concentration-dependent manner. (springer.com)
  • Hence, cadherins provide the framework that links the cell-cell contact on the membrane surface to the cytoskeleton. (rupress.org)
  • Recent studies identified additional E-cadherin-independent roles of αE-catenin in regulating plasma membrane dynamics and cell migration. (biologists.org)
  • PulSA enabled high-throughput tracking of protein aggregation, translocation from the cytoplasm to the nucleus and trafficking from the plasma membrane to the Golgi as well as stress-granule formation. (monash.edu)
  • Last, the potential of the proposed technique (forward-scattering light technique) as a new quantitative investigation of cellular aggregation process was estimated. (spiedigitallibrary.org)
  • These findings open new perspectives for understanding the pathogenesis of protein aggregation in retinal cells and can be useful for the development of therapeutic treatments to prevent retinal cell deterioration. (hindawi.com)
  • These findings suggest the therapeutic applications of novel trehalose analogs in polyglutamine aggregation-associated neurodegenerative diseases. (eurekaselect.com)
  • These findings indicate that P-cadherin promotes intraperitoneal dissemination of EOC by facilitating tumor cell aggregation and tumor-peritoneum interactions in addition to promoting tumor cell migration. (aacrjournals.org)
  • Based on these findings, several distinct mechanisms have been proposed for the recognition of such nonpeptide Ags by human γδ T cells ( 5 ). (jimmunol.org)
  • If proven safe and effective in human clinical studies, 'clinicians could consider these findings when selecting treatment strategies for their patients and for volunteer donors of hematopoietic cells used in transplantation therapies. (news-medical.net)
  • Building on these findings in the new study, Forsberg and her team tested whether Viagra, a vasodilator approved by the U.S. Food and Drug Administration (FDA) for the treatment of erectile dysfunction, might be a viable option for hematopoietic stem cell transplantation. (news-medical.net)
  • By contrast, mice treated with Plerixafor alone showed a nearly 3-fold increase in hematopoietic cells compared to control mice, consistent with findings from previous studies. (news-medical.net)
  • The B-Cell Lymphoma Moon Shot is revolutionizing the conventional medical research approach to rapidly translate findings into patient treatment options and develop personalized therapeutic strategies. (mdanderson.org)
  • MSCs from bone marrow (BM), lipoaspirate (LA) and cord blood (CB) were compared to human umbilical vein endothelial cells or HeLa tumor cells as inhibitory or activating cells, respectively. (biomedcentral.com)
  • Thus, although pamidronate induced cell clustering, proliferation, and IFN-γ production of γδ T cells in the culture of PBMC, it failed to induce any of these activities in the culture of purified primary γδ T cells. (jimmunol.org)
  • Selegiline-a monoamine oxidase inhibitor used for the treatment of Parkinson's disease, reduces apoptosis and increases viability in cultured retinal pigment epithelium cells (APRE-19). (cf.ac.uk)
  • The evolution of a tumor cord cell population. (aimsciences.org)
  • Finite-difference and pseudo-spectral methods for the numerical simulations of in vitro human tumor cell population kinetics. (aimsciences.org)
  • Thus, β-galactoside-mediated intravascular heterotypic and homotypic tumor cell adhesive interactions at the sites of a primary attachment to the microvascular endothelium could play an important role during early stages of hematogenous cancer metastasis. (aacrjournals.org)
  • Over-confluent tumor cells produced even lower number of lung colonies. (rti.org)
  • The most widely recognized pattern of EOC dissemination is intraperitoneal "seeding" in which tumor cells passively shed into, and are transported by, the circulating peritoneal fluid ( 2-4 ). (aacrjournals.org)
  • It is thought that aggregation of floating EOC cells prevents anoikis and also facilitates the implantation of tumor cells on to peritoneal surfaces such as the cavity wall, bowel serosa, and the omentum ( 3-5 ). (aacrjournals.org)
  • Both cell viability and survival only lost less than 20% when the cells were exposed to the high concentration of 100 μg/mL FSNP-SD. (mdpi.com)
  • The RPE cells ensure the survival of neural cells, rod, and cones. (hindawi.com)
  • Homozygous Foxp2 (R552H)-KI mice showed reduced weight, immature development of the cerebellum with incompletely folded folia, Purkinje cells with poor dendritic arbors and less synaptophysin immunoreactivity, and achieved crisis stage for survival 3 weeks after birth. (pnas.org)
  • In our experience we observe a general survival of 3-8% of grafted neural stem cells, which persist over time. (news-medical.net)
  • To clarify the role of α-1,3-glucan in hyphal aggregation, we constructed strains overexpressing agsA ( agsA OE ) or agsB ( agsB OE ), in which the other α-1,3-glucan synthase gene was disrupted. (frontiersin.org)
  • We analyzed the chemical properties of cell wall α-1,3-glucan from the agsA OE and agsB OE strains. (frontiersin.org)
  • We also analyzed localization of α-1,3-glucan in the cell wall of the two strains by fluorescent labeling with α-1,3-glucan-binding domain - fused GFP (AGBD-GFP). (frontiersin.org)
  • Analyses of these data for wild-type strains of Dictyostelium reveals: (a) A pre-aggregation stage of synchronized cringe-chemokinesis oscillations of 5 minute period where amebae stop (speed cringe) and decrease in area (areal cringe) for about fifteen seconds, then extend pseudopods and speed up (positive orthokinesis). (illinois.edu)
  • Embryo Cryopreservation: We will cryopreserve 2-cell embryos for heterozygous males mated to wild type females (for those strains amenable to this procedure) or 2-cell embryos for homozygous males mated to wild type or homozygous females. (mdanderson.org)
  • The effect of normal cellular prion protein (PrP C ) on abnormal protein aggregation was examined by transfecting huntingtin fragments (Htt) into SN56 neuronal-derived cells depleted of PrP C by RNA interference. (biologists.org)
  • Misfolding and accumulation of the protein α-synuclein (αS) inside nerve cells characterize Parkinson's disease (PD) and related brain diseases, for which no disease-modifying therapies exist. (pnas.org)
  • The accumulation of this damage in the postmitotic RPE cells seems to be one of the key events in the development of age-related macular degeneration (AMD), the leading cause of blindness in the elderly in the developed countries. (hindawi.com)
  • Reverse transcription-quantitative PCR data indicated that SpoVG could repress the expression of sasC , which codes for S. aureus surface protein C and is involved in cell aggregation and biofilm accumulation. (asm.org)
  • Pathogenesis of age-related macular degeneration (AMD) involves to impaired degradation of membranous discs shed from photoreceptor outer segments and accumulation of lysosomal lipofuscin in RPE cells. (arvojournals.org)
  • 3.Expression of rhodopsin carrying P23H mutation causes its accumulation in intracellular inclusion bodies in a perinuclear area of photoreceptor cells. (cf.ac.uk)
  • β- and γ-synucleins and heat shock protein Hsp-70, but not α-synuclein, protect cultured ocular cells from mutant opsin accumulation. (cf.ac.uk)
  • Here, we show that the compounds 2,4-dinitrophenol, 3-nitrophenol and 4-anisidine decreased intracellular accumulation of APP in CTb cells. (conicyt.cl)
  • Results indícate that the compounds tested can be leads for the development of drugs to decrease intracellular vesicular accumulation of APP in trisomic cells. (conicyt.cl)
  • IMPORTANCE This study revealed that SpoVG can modulate cell aggregation by repressing sasC expression and extracellular DNA (eDNA) release. (asm.org)
  • These results suggest that microtubule-guided bidirectional mobility of CESA complexes is fine-tuned by phosphorylation of CESA3 S211 and T212, which may, in turn, modulate cellulose synthesis and organization, resulting in or contributing to the observed defects of anisotropic cell expansion. (plantphysiol.org)
  • The behavior of mammalian cells within three-dimensional structures is an area of intense biological research and underpins the efforts of tissue engineers to regenerate human tissues for clinical applications. (biomedsearch.com)
  • Our new special issue is packed with articles that use mathematical and physical approaches to gain insights into cell and tissue patterning, morphogenesis and dynamics, and that provide a physical framework to capture these processes operating across scales. (biologists.org)
  • These surfaces are lined by a monolayer of mesothelial cells that acts as a protective barrier against tissue injury and infection ( 6 ). (aacrjournals.org)
  • administering to a nonhypercholesterolemic subject in need of such treatment a HMG-CoA reductase inhibitor in an amount effective to increase endothelial cell Nitric Oxide Synthase activity in said tissue of the subject. (google.com)
  • There have been numerous models proposed for the neuronal cell loss and spongiform changes in the brain that occur in scrapie, but it is still not clear whether this pathology is due to a loss of functional PrP C or only to a gain of function by PrP Sc . (biologists.org)
  • E710.2.3 is a murine thymic lymphoma cell line with an immature phenotype (CD4 − CD8 − ) that proliferates in response to thymocytes or PMA when cultured at low density and proliferates spontaneously when grown at high density. (jimmunol.org)
  • Pinho, B. R. , Reis, S. D. , Hartley, R. C. , Murphy, M. P. and Oliveira, J. M.A. (2019) Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells. (gla.ac.uk)
  • Irwin J.W. (1973) Blood Cell Aggregation and Pulmonary Embolism. (springer.com)
  • Light-transmission and light-backscattering methods are commonly used to determine red-blood-cell (RBC) aggregation. (spiedigitallibrary.org)
  • This RBC aggregation plays an important role in the flow of blood, particularly in the microvascular system. (spiedigitallibrary.org)
  • Therefore, we investigated the effect of shear-induced platelet activation on red blood cell (RBC) aggregation. (iospress.com)
  • Cristian V. L. Pop , Cristian V. L. Pop, Silvia Neamtu , Silvia Neamtu, } "Aggregation of red blood cells in suspension: study by light-scattering technique at small angles," Journal of Biomedical Optics 13(4), 041308 (1 July 2008). (spiedigitallibrary.org)
  • Conclusions The low HVR levels found in sickle cell anemia and SCC indicates a comparable low oxygen transport potential of blood in both genotypes. (haematologica.org)
  • The rat cremaster muscle was used to visualize arteriolar flows, and the extent of aggregation was raised by dextran 500 infusion to levels seen in normal human blood. (nus.edu.sg)
  • This study shows that the cell-free layer width in arterioles is dependent on both flow rate and red blood cell aggregability, and that the temporal variations in width are asymmetric with a greater excursion into the red blood cell core than toward the vessel wall. (nus.edu.sg)
  • The combination of two clinically approved drugs--Viagra and Plerixafor--rapidly and efficiently mobilizes blood stem cells from the bone marrow into the bloodstream in mice, researchers report October 10th in the journal Stem Cell Reports. (news-medical.net)
  • Hematopoietic stem cell transplantation, which replaces abnormal blood-forming stem cells with healthy cells, is a curative treatment for a variety of blood and immune disorders. (news-medical.net)
  • The researchers next harvested hematopoietic stem cells from the blood or bone marrow of donor mice treated with either Plerixafor alone or a combination of Viagra and Plerixafor and then transplanted these cells into recipient mice. (news-medical.net)
  • Concentrated erythrocyte (i.e., red blood cell) suspensions flowing in microchannels have been simulated with an immersed-boundary lattice Boltzmann algorithm, to examine the cell layer development process and the effects of cell deformability and aggregation on hemodynamic and hemorheological behaviors. (elsevier.com)
  • The flow development process demonstrates how red blood cells migrate away from the boundary toward the channel center, while the suspending plasma fluid is displaced to the cell free layer regions left by the migrating cells. (elsevier.com)
  • Red Blood Cell (rbc) Aggregation, A Normally Occurring Phenomenon And A Major Factor Affecting Blood Rheology, Is An Important Area Of Study Within Bioengineering. (vanstockum.nl)
  • Max Schultze in 1865 described what he called "spherules", which he noted were much smaller than red blood cells, occasionally clumped, and were sometimes found in collections of fibrin material. (wikipedia.org)
  • Thrombocytes are cells found in the blood of non-mammalian vertebrates. (wikipedia.org)