Loading...
  • subtypes
  • Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149). (nih.gov)
  • axonal growth
  • L1 FL and L1 ΔC77 , both of which possess the YRSLE sequence, were expressed in the axonal growth cone and to a lesser degree in the cell body. (jneurosci.org)
  • These data demonstrate that the neuronal form of L1 carries the tyrosine-based sorting signal YRSLE, which is critical for sorting L1 to the axonal growth cone. (jneurosci.org)
  • receptors
  • They may have agonistic or antagonistic effects on the receptors, block ion channel pores or disrupt the interaction with neighboring molecules. (scielo.br)
  • They could also alter receptor localization at the membrane or cause receptor internalization, thus reducing cell surface expression of receptors 7 . (scielo.br)
  • glial
  • Growth cone interactions with a glial cell line from embryonic Xenopus retina. (semanticscholar.org)
  • The four members of the glial cell line-derived neurotrophic factor (GDNF) family of ligands, which include GDNF, neurturin, artemin, and persephin, are homodimers which bind with high affinity to one of the four members of the GDNF receptor α family (GFRα1-4). (plymouth.ac.uk)
  • Ligands that bind the Ret receptor include the glial cell line-derived neurotrophic factor (GDNF) and its congeners neurturin, persephin, and artemin (2-4). (cellsignal.com)
  • regulate
  • Thus, our findings show that specific sulfation along the carbohydrate backbone carries instructions to regulate neuronal function. (biologists.org)
  • These results support the concept that distinct sulfation along the carbohydrate backbone carries instructions to regulate neuronal function. (biologists.org)
  • Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity. (yale.edu)
  • Dietrich MO, Liu Z-W, Horvath TL (2013) Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity. (yale.edu)
  • growth cone
  • Recycling L1 from the C-domain to the leading edge provides an effective way to create asymmetric L1-mediated adhesion and therefore would be critical for L1-based growth cone motility. (jneurosci.org)
  • eukaryotic
  • The formation of filament bundles is a novel and unexpected property of polysialic acid and of short carbohydrate oligomers in general and represents a previously unrecognized molecular interaction mechanism which impacts both eukaryotic and prokaryotic cell-cell adhesions. (biomedsearch.com)
  • Background: Cyclin-dependent kinases (CDKs) are serine/threonine kinases that are activated by cyclins and govern eukaryotic cell cycle progression. (cellsignal.com)
  • substrate
  • However, the effective integration of neuronal bioactivity along with transplantable substrate designs remains a major challenge. (springeropen.com)
  • To investigate the substrate properties of nervous tissue for neuronal adhesion and fiber growth, we used frozen sections of rat CNS and PNS as culture substrates for neuroblastoma cells and for sympathetic and dorsal root ganglia. (semanticscholar.org)
  • circuits
  • Their specific interests cover a broad range of neuroscience research including molecular biophysics, synapses and circuits, neuronal development, integrative neuroscience, brain imaging, neurological disorders and stroke. (nih.gov)
  • metabolism
  • Genome-wide analysis of LP-1-derived cells indicated that several cellular processes were altered by cyclin D1b and/or cyclin K expression such as cell metabolism, signal transduction, regulation of transcription and translation. (biomedcentral.com)
  • pyramidal cells
  • Immunohistochemical analyses of developing mice demonstrated the polarized expression of L1 in pyramidal cells, granule cells, and interneurons in the hippocampus. (jneurosci.org)
  • astrocytes
  • These were just two examples of changes in breathing caused by manipulating the way astrocytes communicate with neighboring cells. (nih.gov)
  • physiological
  • Therefore, we use diverse experimental approaches such as molecular biological techniques, cell culture, mouse genetics, histology, as well as behavioural and physiological experiments. (plymouth.ac.uk)
  • Neurodegenerative
  • Alterations in cell surface protein signalling have been implicated in the pathogenesis of neurodegenerative disorders such as motor neuron diseases, PD and Alzheimer disease (AD) but also in diseases such depression, attention-deficit/hyperactivity disorder (ADHD) and schizophrenia. (plymouth.ac.uk)
  • findings
  • Together, these findings highlight the promise of displays of multimeric neural adhesion ligands via biointerfacially engineered substrates to "cooperatively" enhance neuronal phenotypes on polymers of relevance to tissue engineering. (springeropen.com)
  • mice
  • In vivo antitumor activity of huN901-DM1 was then studied in a tumor xenograft model using a CD56 + OPM2 human MM cell line in SCID mice. (aacrjournals.org)
  • In a new study led by Dr. Dorian McGavern , scientists from the National Institutes of Health watched in real-time as different immune cells took on carefully timed jobs to fix the damaged lining of the brain, also known as meninges, in mice. (nih.gov)
  • Immunocompromised mice injected s.c . with LP-1K or LP-1D1b cells develop tumors at the site of injection. (biomedcentral.com)