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  • organism
  • It contains the consequent analysis of the injury and defensive responses as regards separate cells, organs and tissues and the whole organism. (coursera.org)
  • leucocyte
  • Adhesive interactions, however, are also involved in the pathogenesis of cardiovascular disease, regulating thrombus formation, facilitating leucocyte infiltration, mediating the migration and proliferation of smooth muscle cells, and enabling the deposition of fibrotic tissue. (bmj.com)
  • tumor cells
  • HNSCC invasion is a necessary component of metastasis where tumor cells infiltrate into adjacent tissues, degrading basement membranes and extracellular matrix (ECM), and -disrupting tissue architecture. (springer.com)
  • During tumor progression, tumor cells must overcome a hostile microenvironment that can include hypoxia, growth factor deprivation, and loss of adhesion to the ECM. (springer.com)
  • These cell-cell adhesions are responsible for forming stratifying cell layers, but also influence the differentiated state of the tumor cells, and tend to restrain invasion. (springer.com)
  • The role of certain integrins in stimulating signal transduction, the essential involvement of integrins in conditioning the function of T and NK cells function, the heterogeneity of integrins and its biological consequences, and the role of cell adhesion molecules in tumor cells invasion and metastases are all extensively analyzed. (kobo.com)
  • membrane
  • 1 In addition, they straddle the cell membrane and play an important role in initiating intracellular events in response to extracellular stimuli. (bmj.com)
  • In the remaining 17 per cent of invasive lobular tumours, E-cadherin appeared to have an abnormal distribution within the cytoplasm with variable expression on the cell membrane. (nih.gov)
  • tissues
  • Later in development, NCAM1 (CD56) expression is found on various differentiated tissues and is a major CAM mediating adhesion among neurons and between neurons and muscle. (wikidoc.org)
  • Normal cells that stain positively for CD56 include NK cells , activated T cells , the brain and cerebellum , and neuroendocrine tissues. (wikidoc.org)
  • They determine a variety of lymphocyte functions but, perhaps more importantly in the context of cardiovascular disease, they also play a pivotal role in the "trafficking" of leucocytes through tissues, interacting with β 2 integrins on white cells. (bmj.com)
  • Two distinct calcium-sensitive cell-cell adhesion molecules were identified in human epithelial tissues and carcinomas using two monoclonal antibodies raised against vulvar epidermoid carcinoma A-431 and human mammary carcinoma MCF-7 and selected on the basis of their activities to disrupt cell-cell adhesion. (aacrjournals.org)
  • Crown antibodies pass additional stringent quality requirements, including extended control sets, uniform results against multiple biologically relevant cell lines and tissues, and function in multiple applications. (abgent.com)
  • proliferation
  • This is seemingly in contrast to studies with BM stromal cell clones from VCAM-1 null mice, where long-term maintenance and proliferation of clonable pre-B cells, cobblestone formation, and differentiation to IgM-secreting mature B cells were equally possible on VCAM-1 + and VCAM-1 − BM stromal cells ( 35 ). (rupress.org)
  • carcinomas
  • There is experimental evidence that loss of E-cadherin is associated with increased invasiveness of malignant cells in vitro, which stimulated us to examine the presence and distribution of E- and P-cadherin in breast carcinomas by means of immunohistochemical staining. (nih.gov)
  • We suggest that loss of cell-cell adhesion mediated by E-cadherin plays a part in the characteristic morphology of lobular carcinomas. (nih.gov)
  • squamous cell carc
  • The primary reason for treatment failure in patients with head and neck squamous cell carcinoma (HNSCC) is local tumor cell invasion. (springer.com)
  • Alt-Holland A, Zhang W, Margulis A, Garlick JA (2005) Microenvironmental control of premalignant disease: the role of intercellular adhesion in the progression of squamous cell carcinoma. (springer.com)
  • Correlation between immunohistochemical staining of CEACAM1 and clinicopathological findings in oral pre-neoplastic lesions and squamous cell carcinoma. (nih.gov)
  • plasma
  • Mice homozygous for a knock-out allele exhibit small Peyer's patches and decreased homing of IgA-secreting plasma cells in the lamina propria. (jax.org)
  • adherence
  • Numerous molecules participate in one or more steps in an integrated multistep process of leukocyte rolling on the blood vessel wall, followed by "activation," firm adherence, and transmigration into tissue ( 1 )( 2 )( 3 ). (rupress.org)
  • colorectal
  • Further development of CUR-encapsulated, nanosized carriers will lead to improved targeted delivery of novel chemotherapeutic agents to colorectal cancer cells. (dovepress.com)
  • Function
  • The structure and function of these molecules is outlined briefly, followed by an assessment of their importance in cardiac disease. (bmj.com)
  • Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity). (uniprot.org)
  • apoptosis
  • Although not normally expressed by T cells, VCAM-1 is reportedly expressed by thymocytes and T cells undergoing apoptosis ( 33 ). (rupress.org)
  • role
  • With timely presentations and stimulating discussions this Symposium addressed the genetics and biochemistry of adhesion molecules, the regulation of their functions and their role in cancer and the immune system. (kobo.com)
  • VCAM-1 on BM stromal cells might have a role in B cell development. (rupress.org)
  • name
  • As their name suggests they mediate the adhesion of cells to each other and to surrounding substrates, "integrating" the cell with its environment. (bmj.com)