Cell adhesion beta catenin. Medical search. Frequent questions

The CTNNB1 gene provides instructions for making a protein called beta-catenin . (medlineplus.gov)
Mutations in the CTNNB1 gene lead to a version of beta-catenin that is always turned on (constitutively active). (medlineplus.gov)
The CTNNB1 gene mutations that cause desmoid tumors are somatic, which means they are acquired during a person's lifetime and are present only in tumor cells. (nih.gov)
Full length human recombinant protein of human CTNNB1 (NP_001895) produced in HEK293T cell. (origene.com)
Homo sapiens catenin beta 1 (CTNNB1), transcript variant 1, mRNA. (origene.com)
Formalin-fixed, paraffin-embedded human Tonsil stained with Beta-Catenin (p120) Monoclonal Antibody (CTNNB1/1509). (neobiotechnologies.com)
Mutations in beta catenin gene (CTNNB1) leads accumulation of the beta catenin protein in cytoplasm and nucleus in different type of tumors eg. (newmarketscientific.com)
Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. (nih.gov)
2003. Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun. . (oregonstate.edu)
2002. Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline. . (oregonstate.edu)

Decreased expression of alpha-catenin (17%), beta catenin (4%), p120 CTN (45%), and E-cadherin (25%) proteins was noted in PACs with downregulation of each protein correlating with high tumor grade (P = 0.01-0.0001). (nih.gov)
In adherens junctions, alpha-catenin links the cadherin-beta-catenin complex to the actin-based cytoskeleton. (nih.gov)
alpha-catenin is a homodimer in solution, but forms a 1:1 heterodimer with beta-catenin. (nih.gov)
The crystal structure of the alpha-catenin dimerization domain, residues 82-279, shows that alpha-catenin dimerizes through formation of a four-helix bundle in which two antiparallel helices are contributed by each protomer. (nih.gov)
A chimera consisting of the alpha-catenin-binding region of beta-catenin linked to the amino terminus of alpha-catenin 57-264 behaves as a monomer in solution, as expected, since beta-catenin binding disrupts the alpha-catenin dimer. (nih.gov)
Crystal structure of the M-fragment of alpha-catenin: implications for modulation of cell adhesion. (nih.gov)
In plakoglobin arm repeats bind alpha-catenin and N-cadherin. (embl.de)
van Buul JD, van Alphen FP, Hordijk PL. The presence of alpha-catenin in the VE-cadherin complex is required for efficient transendothelial migration of leukocytes. (ijbs.com)
Beta-catenin connects VE-cadherin to alpha-catenin. (ijbs.com)
In order to study the importance of the interaction between alpha- and beta-catenin in TEM, we used a cell-permeable version of the peptide encoding the binding site of alpha-catenin for beta-catenin (S27D). (ijbs.com)
In conclusion, our results show for the first time that the association of alpha-catenin with the cadherin-catenin complex is required for efficient leukocyte TEM. (ijbs.com)
It associates to the armadillo-family proteins beta- and gamma-catenin that bind the actin-binding protein alpha-catenin [ 1 , 2 ]. (ijbs.com)
Ozawa and Kemler showed that increased levels of tyrosine phosphorylation, induced by pervanadate promote the dissociation of alpha-catenin from the cadherin-catenin complex [ 10 ]. (ijbs.com)
Moreover, their results indicated that the binding of alpha-catenin to the cadherin-catenin complex is a prerequisite for proper functioning cadherin-catenin complex, since an E-cadherin-alpha-catenin chimera was insensitive to pervanadate treatment leaving E-cadherin trans-interactions intact, whereas cells expressing the normal cadherin-catenin complex, including beta-catenin, showed loss of cell-cell contact after pervanadate treatment [ 10 ]. (ijbs.com)
Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. (thermofisher.cn)
Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN . (nih.gov)

The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. (wikipedia.org)
In the cell nucleus, the protein MUC1 regulates the activity of transcription factor complexes that have a documented role in tumor-induced changes of host immunity. (wikipedia.org)
This protein plays an important role in sticking cells together (cell adhesion) and in communication between cells. (medlineplus.gov)
This protein is active in cells that make up a part of the hair follicle known as the matrix. (medlineplus.gov)
The overactive protein triggers matrix cells to divide too quickly and in an uncontrolled way, leading to the formation of a pilomatricoma. (medlineplus.gov)
8. Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. (nih.gov)
This protein is present in many types of cells and tissues, where it is primarily found at junctions that connect neighboring cells (adherens junctions). (nih.gov)
Certain proteins in this pathway attach (bind) to beta-catenin, which triggers a multistep process that allows the protein to move into the cell nucleus. (nih.gov)
They change single protein building blocks (amino acids) in the beta-catenin protein. (nih.gov)
These mutations lead to an abnormally stable beta-catenin protein that is not broken down when it is no longer needed. (nih.gov)
As a result, the protein accumulates within cells. (nih.gov)
They cause the beta-catenin protein to be turned on all the time (constitutively active), which leads to the abnormal activation of certain genes. (nih.gov)
This active beta-catenin protein promotes Wnt signaling longer than normal, which leads to the unchecked proliferation of kidney cells and tumor development. (nih.gov)
E-cadherin is an essential adhesion protein as well as a tumor suppressor that is silenced in many cancers. (nih.gov)
The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. (origene.com)
The adenomatous polyposis coli tumor suppressor protein is also implicated in beta-catenin signaling. (embl.de)
HDGC is defined by the presence of germline pathogenic variants in the CDH1 gene, which codes for the cell-cell adhesion junction protein, E-cadherin. (cancer.gov)
This gene codes for an adhesion junction protein, alpha-E-catenin. (cancer.gov)
These include BCL2, an anti-apoptotic protein which promotes immortality in cells, and TP53, which normally promotes apoptosis but is defective and easier to detect with IHC when mutated. (stratech.co.uk)
Another useful IHC marker for TNBC is the ΔNp63 isoform of transcription factor TP63, a protein involved in regulating cell adhesion that is regularly overexpressed in triple negative tumors (Nekulova, 2016). (stratech.co.uk)
Macromolecules such as nucleic acids, genetic alterations, and protein molecules as well as intact cells are utilized as diagnostic biomarkers in breast cancer. (innohealthmagazine.com)
Beta-catenin is a multifunctional oncogenic protein that contributes fundamentally to cell development and biology. (biomedcentral.com)
Beta-catenin protein is a vital component of the canonical Wnt/β-catenin signaling pathway, which is described as an oncogenic cause in many human cancers [ 1 ]. (biomedcentral.com)
The junctional protein Vascular Endothelial (VE)-cadherin is transiently re-distributed from sites of cell-cell contacts during passage of leukocytes. (ijbs.com)
VE-cadherin is part of a protein complex comprising p120-catenin and beta-catenin as intracellular partners. (ijbs.com)
Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. (thermofisher.cn)
Studies show that Beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases, phosphatases and Wnt/Wingless. (thermofisher.cn)
It mediates cell-cell adhesion with cadherins and it is key regulatory protein in signaling through the WNT pathway. (newmarketscientific.com)
The encoded protein is an oncofetal antigen that is specific to trophoblast cells. (nih.gov)
In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. (nih.gov)
These mechanical signal transduction will translate physical signals into biochemical activators (ion channels, the FA kinase, protein G, via MAPK (2 BMP-related), RhoA) and will exert a cytoskeleton regulation which will ultimately change shape and cell volume leading to a differential gene expression in response to an external mechanical stimuli. (oatext.com)
β-Catenin is a fascinating protein with many important cellular and developmental functions. (chemdiv.com)
The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
β -catenin has many binding partners that mediate a diverse set of cellular functions, and the protein probably acts as a 'hub' on which many cellular signaling networks impinge. (chemdiv.com)
This library represents a selection of drug-like compounds aimed at modulating protein-protein interaction (PPI) of β-catenin with different proteins involved in significant physiological processes. (chemdiv.com)
Protein tyrosine phosphatase, which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. (shu.edu)
PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. (anticorps-enligne.fr)
Cosmc protein and O -glycosyltransferase (T-synthase and C3GnT) activity in CRC cells were, respectively, assessed using western blotting and fluorescence method. (biomedcentral.com)
Both SP cells derived from hUCMSCs and hPMSCs could inhibit proliferation and migration, promote apoptosis of CRC cells, significantly reduce Tn antigen expression on Tn + CRC cells, generate new core 1-, 2-, and 3-derived O -glycans, increase T-synthase and C3GnT activity, and elevate the levels of Cosmc and T-synthase protein. (biomedcentral.com)
Insulin supresses transcriptional activity of yes-associated protein in insulin target cells. (nih.gov)
Translocating the CagA protein into the gastric epithelial cells causes rearrangement of the host cytoskeleton and alters cell signaling and perturbs cell cycle control. (medscape.com)

proliferation) of cells and helps determine the specialized functions a cell will have (differentiation). (medlineplus.gov)
20. Ras signaling is essential for lens cell proliferation and lens growth during development. (nih.gov)
Whole genome transcriptome profiling of animal lungs revealed significant alterations in the expression of many genes with functions in cell adhesion and migration, channels, receptors, differentiation and proliferation, and, most strikingly, aspects of the innate immune response. (nih.gov)
The Wnt signaling pathway promotes the growth and division (proliferation) of cells and helps determine the specialized functions a cell will have (differentiation). (nih.gov)
Excess beta-catenin promotes the uncontrolled proliferation of cells, allowing the formation of desmoid tumors. (nih.gov)
These genes increase the proliferation and differentiation of cells associated with the hair follicle matrix. (nih.gov)
Cell growth and proliferation is associated with β-catenin translocation from the cytoplasm into the nucleus. (biomedcentral.com)
The nuclear β-catenin has an important function in many human malignancies [ 1 ] by stimulating cell growth and proliferation. (biomedcentral.com)
Also, constitutive wg signaling causes over-proliferation and abnormal differentiation of somatic follicle cells. (biologists.com)
This work demonstrates that wg signaling regulates SSC maintenance and that its constitutive signaling influences follicle cell proliferation and differentiation. (biologists.com)
In mammals, constitutive β-catenin causes over-proliferation and abnormal differentiation of skin cells, resulting in skin cancer formation. (biologists.com)
Possibly, mechanisms regulating proliferation and differentiation of epithelial cells, including epithelial stem cells, is conserved from Drosophila to man. (biologists.com)
Cell proliferation. (lookformedical.com)
Signal transduction plays an important role in activating cellular functions, cell differentiation , and cell proliferation . (lookformedical.com)
PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types. (lookformedical.com)
However, cell proliferation was invariable in accordance with a regular expression of Ki-67 and P53. (researchsquare.com)
In the nucleus, beta-catenin serves to co activate a family of Lef/Tcf transcription factors that stimulate transcription of target genes including those encoding cyclin D and c-myc that promote cell proliferation. (thermofisher.cn)
Beta catenin has a role in cellular proliferation, differentiation and development. (newmarketscientific.com)
May play a role in the polarity, proliferation and migration of endothelial cells. (nih.gov)
Our aim was to evaluate the copy number alterations of chromosomes 3, 7, 8, and 17 in middle ear cholesteatomas and define the association between the rate of cell proliferation and chromosome number changes. (unideb.hu)
Cell proliferation was characterized with Ki-67 monoclonal antibody on cholesteatoma samples and on postauricular skins as control. (unideb.hu)
CONCLUSIONS: Based on our results, we assume that aneusomy of chromosomes 7, 8, and 17 might play an important role during invasion of the adjacent bony structures of cholesteatoma, as well as associate with increased cell proliferation activity, which might lead to the aggressive behavior of the tissue. (unideb.hu)
WNT/Beta-catenin pathway plays a key role in stem cell differentiation as well as other biological processes such as cell adhesion, proliferation or even invasion in tumor microenvironments. (oatext.com)
these stimuli regulate cell adhesion (of great interest in the tumoral pathology, described for the first time by Curtis [1], cell proliferation and differentiation. (oatext.com)
Uncleaved Gli travels to the nucleus and is an inducer of transcription, increasing Cyclin D1 and stimulating the cell cycle (proliferation). (shu.edu)
2003. Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling. . (oregonstate.edu)
This study clarified the mechanism by which miR-138 regulates proliferation, invasion, metastasis, and EMT in cervical cancer cells. (biomedcentral.com)
They have a critical role in regulation of cell proliferation and migration. (biomedcentral.com)
The proliferation, migration, apoptosis, Tn antigen expression, and O -glycome in Tn + and Tn − CRC cells before and after co-cultured with SP-MSCs were detected using real-time cell Analysis (RTCA), flow cytometry (FCM), and cellular O -glycome reporter/amplification (CORA), respectively. (biomedcentral.com)
SP-hUCMSCs and SP-hPMSCs could inhibit proliferation and migration and promote apoptosis of Tn + CRC cells via increasing O -glycosyltransferase activity to modify O -glycosylation status, which further adds a new dimension to the treatment of CRC. (biomedcentral.com)
IPAT significantly inhibited cell proliferation, caused cell cycle G1 phase arrest, and induced cellular stress and mitochondrial apoptosis in a dose dependent manner in human endometrial cancer cell lines. (bvsalud.org)
Combined treatment with low doses of IPAT and PTX led to synergistic inhibition of cell proliferation and induction of cleaved caspase 3 activity in the human endometrial cancer cell lines and the primary cultures. (bvsalud.org)
Shigella effector OspB activates mTORC1 in a manner that depends on IQGAP1 and promotes cell proliferation. (nih.gov)

It is also involved in cell signaling as part of the Wnt signaling pathway . (medlineplus.gov)
15. Patterns of Wnt pathway activity in the mouse incisor indicate absence of Wnt/beta-catenin signaling in the epithelial stem cells. (nih.gov)
In adult tissues, this pathway plays a role in the maintenance and renewal of stem cells, which are cells that help repair tissue damage and can give rise to other types of cells. (nih.gov)
Beta-catenin participates in signal transduction and developmental patterning in Xenopus and Drosophila embryos as a component of the Wnt signaling pathway. (embl.de)
Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. (lookformedical.com)
The Wnt pathway mediates the biological processes of the canonical or non-canonical pathway, depending on the involvement of β-catenin in signal transduction. (chemdiv.com)
The recently described role of the Wnt/β-catenin pathway in the regulation of immune cell infiltration of microenvironment tumor resumes interest because of its potential impact to rection of immune therapy. (chemdiv.com)
This article presents the roles of the Wnt/β-catenin pathway in cancer and current therapeutic strategies involving this pathway. (chemdiv.com)
Nussе and Varmus identified components of the Wnt/β-catenin pathway in 1982 in a study of oncogenic breast tumor viral diseases (MMTV) [1]. (chemdiv.com)
The Sonic hedgehog (Hh) pathway is known to be important in basal cell carcinoma (BCC), which as an extremely common skin cancer that only rarely invades and metastasizes . (shu.edu)
It mediates beta-catenin dephosphorylation at adhesion junctions and acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. (shu.edu)
Wnt/beta-catenin pathway deregulation in childhood adrenocortical tumors. (cdc.gov)

2. Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. (nih.gov)
3. Wnt signaling enhances FGF2-triggered lens fiber cell differentiation. (nih.gov)
Focal spindling due to noncohesion of tumor cells is not considered to represent sarcomatoid differentiation. (medscape.com)
IHC is further useful for determining rates of cell differentiation, elucidating molecular pathways, and highlighting the proteomics of tumor growth and metastatic potential. (stratech.co.uk)
PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. (nih.gov)
The complex processes of initiating CELL DIFFERENTIATION in the embryo. (lookformedical.com)
Background: Sex-determining region Y-box 9 (SOX9) is an important transcription factor for the development and differentiation of cells and their organization. (iiarjournals.org)

During EMT, adhesion molecules like E-cadherin are downregulated and the decrease of cell-cell adhesion allows tumour cells to dissociate from the primary tumour mass. (biomedcentral.com)
In human skin, DCXR localizes to the cytoplasm near the adhesion molecules, e-cadherin and beta-catenin. (cdc.gov)
Therefore, we hypothesized that diacetyl causes apoptosis and changes in epithelial adhesion molecules. (cdc.gov)
Important adaptive features that enhance survival of the organism in an acidic environment include its shape and motility, its reduced oxygen requirement, its adhesion molecules that are trophic to certain gastric cells, and its urease production. (medscape.com)

Catenin/E-cadherin complex proteins play an important role in cell-cell adhesion with decreased expression correlating with adverse prognostic variables in several human malignancies. (nih.gov)
Archival formalin fixed, paraffin embedded (FFPE) sections from 118 prostatic adenocarcinomas (PACs) were immunostained by an automated method (Ventana Medical Systems, Tuscon, AZ) using monoclonal antibodies to catenins alpha and beta, p120 CTN, and E-cadherin proteins. (nih.gov)
11. Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins. (nih.gov)
Once in the nucleus, beta-catenin interacts with other proteins to control the activity (expression) of particular genes. (nih.gov)
It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. (embl.de)
Together, these proteins form the so-called cadherin-catenin complex. (ijbs.com)
Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. (lookformedical.com)
Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. (thermofisher.com)
The molecular weight of proteins were 102, 88 and 80 kDa, so they were named α, β and γ-catenin. (chemdiv.com)

A core region of beta-catenin, composed of 12 copies of a 42 amino acid sequence motif known as an armadillo repeat, mediates these interactions. (embl.de)
We and others have previously reported that inhibition of VE-cadherin function by the use of blocking antibodies promotes transendothelial migration of neutrophils and CD34 + cells in vitro and in vivo [ 6 - 8 ], suggesting that VE-cadherin mediates transendothelial migration of leukocytes. (ijbs.com)
Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. (nih.gov)

Association of MUC1 with p53 in cancer results in inhibition of p53-mediated apoptosis and promotion of p53-mediated cell cycle arrest. (wikipedia.org)
17. Wnt/beta-catenin signaling inhibits death receptor-mediated apoptosis and promotes invasive growth of HNSCC. (nih.gov)
Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. (lookformedical.com)
Many cytotoxic agents cause both apoptotic and necrotic cell death but the role of apoptosis in diacetyl -induced cell death is unknown. (cdc.gov)
These findings indicate that both apoptosis and necrosis contribute to diacetyl -induced epithelial injury and suggest that diacetyl may alter intercellular adhesion complexes of respiratory epithelium. (cdc.gov)
Studies of epithelial cell lines such as Madin-Darby canine kidney (MDCK) cells have, for instance, revealed polarity and apoptosis pathways contributing mechanistically to lumen formation 1 . (nature.com)

Sarcomatoid renal cell carcinoma (SRCC) is currently defined in the 2004 World Health Organization (WHO) classification of renal tumors as any histologic type of renal cell carcinoma (RCC) containing foci of high-grade malignant spindle cells. (medscape.com)
however, occasional tumors composed entirely of rhabdoid cells have been described in which no RCC component is detected despite extensive sampling. (medscape.com)
This study aimed to evaluate the effect of cryopreservation on ZR-75-1 and MDA-MB-231 human breast cancer cells in the form of compacted fragments (as a model of solid tumors). (researchsquare.com)
Hypoxia and acidosis are salient features of many tumors, leading to a completely different metabolism compared to normal cells. (mdpi.com)
Inhibition of tumor-associated CAs leads to an impaired growth of the primary tumors, metastases and reduces the population of cancer stem cells, leading thus to a complex and beneficial anticancer action for this class of enzyme inhibitors. (mdpi.com)
2001. beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol. . (oregonstate.edu)
Protocol GOG-8032 within GOG-210 was designed to determine whether these tumors differ from pure clear cell carcinoma in stage at diagnosis, initial pattern of spread, or patient survival. (bvsalud.org)
Patients whose tumors had indeterminate clear cell features had better prognosis. (bvsalud.org)
Some of these tumors may be endometrioid tumors mimicking clear cell carcinoma. (bvsalud.org)

These mutations are somatic, which means they are acquired during a person's lifetime and are present only in tumor cells. (medlineplus.gov)
Chan EF, Gat U, McNiff JM, Fuchs E. A common human skin tumour is caused by activating mutations in beta-catenin. (medlineplus.gov)
These mutations are somatic and occur only in kidney cells that give rise to the tumor. (nih.gov)
Researchers genetically profiled nearly 300 basal cell carcinoma (BCC) samples , and found additional recurrent mutations - including ones in MYCN, PTPN14, and LATS1 - that appear to drive disease. (shu.edu)

Beta-catenin is degraded in the cytoplasm by glycogen synthase kinase 3 beta (GSK-3β) through phosphorylation. (biomedcentral.com)
Beta-catenin is expressed in the cytoplasm and the nucleus. (biomedcentral.com)
The cytoplasm β-catenin, as a component of adherens junctions (AJs) [ 11 ], is an essential element of cell-to-cell adhesion and stability. (biomedcentral.com)
In the presence of Wnt signaling, β-catenin destruction complex is disassembled by removing axin [ 18 , 19 ] resulting in β-catenin accumulation in the cytoplasm. (biomedcentral.com)
The accumulated cytoplasm β-catenin hence enters the nucleus to initiate its oncogenic function. (biomedcentral.com)
It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION. (lookformedical.com)
Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell. (lookformedical.com)
However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. (neobiotechnologies.com)

16. Tumor progression induced by the loss of E-cadherin independent of beta-catenin/Tcf-mediated Wnt signaling. (nih.gov)
EGFR regulation by E-cadherin was associated with complex formation between EGFR and E-cadherin that depended on the extracellular domain of E-cadherin but was independent of beta-catenin binding or p120-catenin binding. (nih.gov)

Signal transduction of beta-catenin. (embl.de)

We report that E-cadherin can negatively regulate, in an adhesion-dependent manner, the ligand-dependent activation of divergent classes of receptor tyrosine kinases (RTKs), by inhibiting their ligand-dependent activation in association with decreases in receptor mobility and in ligand-binding affinity. (nih.gov)
This VE-cadherin-catenin complex is believed to dynamically control endothelial cell-cell junctions and to regulate the passage of leukocytes, although not much is known about the role of alpha- and beta-catenin during the process of transendothelial migration (TEM). (ijbs.com)
The interplay between beta-catenin, cytoskeletal complexes and signaling pathways may regulate morphogenesis. (thermofisher.cn)

Its signaling activity is distinct from its role in cadherin-mediated cell adhesion, and it probably acts either in the cytosol or in the nucleus. (embl.de)
Speaking more specifically, β-catenin is an integral structural component of cadherin-based adhesive junctions as well as it a key nuclear effector of canonical in nucleus Wnt signaling. (chemdiv.com)

Papers may also include studies of matrix remodeling (proteolysis, contraction, synthesis), matrix-driven phenotype, or tissue architecture regulation of cellular processes, as well as evaluation of critical biomaterial design parameters for controlling cell adhesion and migration. (aiche.org)
Its adhesion-dependent regulation of signaling has not been elucidated. (nih.gov)
This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. (nih.gov)
The catenins are thought to play an important role in the regulation of VE-cadherin function. (ijbs.com)
β-catenin signalling has an important role in conjunction with other oncogenic pathways in the regulation of host responses to H. pylori that have carcinogenic potential. (nature.com)
The precise regulation by cell interactions leads to diversity of cell types and specific pattern of organization (EMBRYOGENESIS). (lookformedical.com)
The model is a multiscale cellular automaton that couples intracellular adhesion receptor regulation with cell-cell adhesion. (biomedcentral.com)
This effect can be at least partially compensated by a control of adhesion receptor regulation through neighbouring cells. (biomedcentral.com)
Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). (neobiotechnologies.com)

549e) The Micromechanics and Physics of Cancerous Cells: What Are the Physical Hallmarks of Cancer Metastasis? (aiche.org)
Cryopreservation causes an increasing malignancy of ZR-75-1 and MDA-MB-231 cells and thus raises the risk of metastasis. (researchsquare.com)
Cancer cell invasion, dissemination, and metastasis have been linked to an epithelial-mesenchymal transition (EMT) of individual tumour cells. (biomedcentral.com)
A consequence of this is that therapies targeting tumour cell dissemination and metastasis formation are largely under-represented [ 7 ]. (biomedcentral.com)
In addition to multiple intra- and extracellular functions, it facilitates migration of tumour cells, has crucial role in cell adhesion and is associated with increased metastasis formation. (unideb.hu)
An imbalance in the structural and signaling properties of β-catenin often leads to disease and unregulated growth associated with cancer and metastasis. (chemdiv.com)
Cosmc (C1GalT1C1) mutation could cause aberrant O -glycosylation and result in expression of Tn antigen on the surface of tumor cells (Tn + cells), which is associated with the metastasis and prognosis of cancer progression. (biomedcentral.com)
Recurrence or metastasis of HCC is mainly intrahepatic, which shows that peritumoral liver tissue may be a favorable soil for spreading hepatoma cells [ 4 ]. (hindawi.com)

Although unrelated in sequence, the beta-catenin binding regions of cadherins, Tcfs, and APC are acidic and are proposed to interact with this groove. (embl.de)

This session will focus on experimental and theoretical aspects of prokaryotic and eukaryotic cell adhesion/migration. (aiche.org)
Mono-(2-ethylhexyl) phthalate (MEHP) promotes invasion and migration of human testicular embryonal carcinoma cells. (nih.gov)
Addition of the MMP2-specific inhibitor SB-3CT inhibited MEHP-enhanced cell invasion and migration, demonstrating that MMP2 plays a functional role in promoting testicular embryonal carcinoma progression in response to MEHP exposure. (nih.gov)

MUC1 cytoplasmic tail was shown to interact with Beta-catenin. (wikipedia.org)
Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. (neobiotechnologies.com)
Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas. (neobiotechnologies.com)

This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs. (lookformedical.com)
In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. (neobiotechnologies.com)
In mature animals, Wnts maintain stem cell populations in a variety of tissues, including blood, bone, hair follicles and gut (reviewed by Clevers, 2006 ). (silverchair.com)
Human pluripotent stem cells (hPSCs) are capable of extensive self-renewal and can differentiate into diverse somatic cell types and tissues. (nature.com)
Like most stem cells, they isolated from different tissues were consisting of various subpopulations and have certain heterogeneity which created variations in therapeutic efficacy. (biomedcentral.com)

Appropriate papers include those addressing fundamental molecular mechanisms of cell-cell and cell-matrix/surface interactions in two or three dimensional structures, as well as the roles of these cellular processes in tissue engineering, cell physiology or biotechnology. (aiche.org)
9. Cellular localization and signaling activity of beta-catenin in migrating neural crest cells. (nih.gov)
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. (lookformedical.com)
In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. (neobiotechnologies.com)
Functionally, integrins are cell surface receptors that interact with the extracellular matrix and mediate intracellular signals that affect cellular shape, mobility, and progression through the cell cycle in response to the extracellular matrix. (thermofisher.com)
Quercetin affects glutathione levels and redox ratio in human aortic endothelial cells not through oxidation but formation and cellular export of quercetin-glutathione conjugates and upregulation of glutamate-cysteine ligase. (oregonstate.edu)
Despite these limitations, interest in the cellular microenvironment and 3D culture systems has been increasing steadily, particularly for stem cell applications 2 . (nature.com)

A cell line derived from cultured tumor cells. (lookformedical.com)
Moreover, aberrant expression of miRNAs has been associated with therapeutic resistance in cancer that suggests these factors as probable efficient therapeutic targets in tumor cells [ 8 ]. (biomedcentral.com)
The effect of SP cells derived from MSCs on the biological behaviors and the O -glycosylation status of tumor cells remains unclear. (biomedcentral.com)

Microarray analysis and semiquantitative RT-PCR revealed that MEHP exposure primarily influenced genes in cell adhesion and transcription in NT2/D1 cells. (nih.gov)
We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. (stowers.org)

Unlike most negative regulators of Wnt activity, Pbl/ECT2 functions downstream of Armadillo (Arm)/beta-catenin stabilization. (silverchair.com)
β-catenin is a component of the complex cadherin complex whose stabilization is required to activate Wnt/β-catenin signaling. (chemdiv.com)

Within the past year, Armadillo and beta-catenin's role in transducing the Wingless/Wnt signal has been substantially clarified. (embl.de)
Three-dimensional structure of the armadillo repeat region of beta-catenin. (embl.de)
The three-dimensional structure of a protease-resistant fragment of beta-catenin containing the armadillo repeat region has been determined. (embl.de)

It is also possible that MUC1 facilitates the vascular spread of carcinoma cells by helping them to remain detached from the endothelial cells. (bmj.com)
The majority of the leukocytes cross the endothelial lining of the vessels through cell-cell junctions. (ijbs.com)
The data show that S27D interferes with the interaction between alpha- and beta-catenin and induces a reversible decrease in electrical resistance of the endothelial monolayer. (ijbs.com)
Vascular Endothelial Cadherin (VE-cadherin, Cadherin-5) is specifically expressed in endothelial cells and localizes at adherens junctions. (ijbs.com)
VE-cadherin is a calcium-dependent and homophilic transmembrane adhesion molecule that bridges adjacent endothelial cells. (ijbs.com)
Because VE-cadherin-mediated cell-cell junctions hold the endothelial cells tightly together, the endothelial layer functions as a barrier for macromolecules and leukocytes and thereby protects the underlying tissue from damage. (ijbs.com)
However, under certain (pathologic) conditions, such as inflammation, traffic of leukocytes across the endothelial layer through the cell-cell junctions is required. (ijbs.com)
Lampugnani and co-workers showed that tyrosine phosphorylation of VE-cadherin and associated catenins is increased in loosely confluent endothelial monolayers, whereas the phosphorylation is diminished in tightly confluent monolayers [ 9 ]. (ijbs.com)
Quercetin inhibits LPS-induced adhesion molecule expression and oxidant production in human aortic endothelial cells by p38-mediated Nrf2 activation and antioxidant enzyme induction. (oregonstate.edu)

The increased likelihood of mutation in the affected gene and the chance of sporadic mutation in the other APC of that cell eventually lead to the development of the attenuated phenotype. (medscape.com)
An α-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer. (cancer.gov)

Beta-catenin is essential for cadherin-based cell adhesion and Wnt/Wingless growth factor signaling. (embl.de)

IHC markers can be used to identify the deregulation or pathogenic activation of various cell-cycle pathways in breast cancer. (stratech.co.uk)
These metabolic pathways triggered by mechanical stimuli could be translated through a tensegrity model (Ingber), which gives a new dimension to the role of the interrelation of cells and extracellular matrix. (oatext.com)
Cooperative participation of epigenomic and genomic alterations in the clinicopathological diversity of gastric adenocarcinomas: significance of cell adhesion and epithelial-mesenchymal transition-related signaling pathways. (cdc.gov)

Recombinant GAPDH (rGAPDH) was found to be able to bind porcine-derived PK-15 and human-derived NCI-H292 cells. (biomedcentral.com)

In ZR-75-1 cells, data exhibited a downregulation of E-cadherin after the decreased expression of GATA3, indicating the loss of intercellular adhesion after cryopreservation. (researchsquare.com)

This complex process depends on intracellular cues that are subject to genetic and epigenetic variability, as well as extrinsic cues from the local environment resulting in a spatial heterogeneity in the adhesive phenotype of individual tumour cells. (biomedcentral.com)
In particular, we show that a large variation of intracellular adhesion receptor concentrations in a cell population reinforces cell dissemination, regardless of extrinsic cues mediated through the local cell density. (biomedcentral.com)

Identifying the signals involved in maintaining stem cells is critical to understanding stem cell biology and to using stem cells in future regenerative medicine. (biologists.com)
In the Drosophila ovary, Hedgehog is the only known signal for maintaining somatic stem cells (SSCs). (biologists.com)
Identification of the signals involved in the communication between stem cells and their niches is important for understanding stem cell biology and its role in future regenerative medicine. (biologists.com)
The adult ovary contains 12-16 ovarioles, each with a germarium at the tip, in which GSCs and somatic stem cells (SSCs) are located( Fig. 1A ). (biologists.com)
These stem cells directly contact cap cells and are posterior to terminal filament cells. (biologists.com)
After a GSC divides,the daughter still in contact with cap cells remains a stem cell, whereas the daughter that is more distant from cap cells differentiates into a cystoblast. (biologists.com)
However, if both daughters remain in contact with cap cells, they both become stem cells ( Xie and Spradling,2000 ). (biologists.com)
In this work we describe how stem cells cultured on a scaffold in a bioreactor are able to modulate their response to a cyclic flow translating it into a differential expression of WNT3a and beta-catenin. (oatext.com)
Mesenchymal stem cells (MSCs) are defined by a clonogenic capability as well as the ability to differentiate into several cell types. (oatext.com)
Wnt/β-catenin signaling is a branch of a functional network that is involved in a broad range of biological systems including stem cells, embryonic development and adult organs. (chemdiv.com)
Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important potential for disease modelling and regeneration. (nature.com)
Both undifferentiated stem cells and terminally differentiated somatic cells form epithelia. (nature.com)
Mesenchymal stem cells (MSCs) could participate in immunoregulation, tissue damage repair, and tumor inhibition and be seen as an ideal candidate for tumor therapy due to their inherent capacity to migrate to tumor sites. (biomedcentral.com)
Of note, emerging data reveal that side population (SP) cells have a stronger multilineage developmental potential than main population cells and can function as stem/progenitor cells. (biomedcentral.com)
With the development of cell therapy and related disciplines, mesenchymal stem cells (MSCs) have been widely used in the experimental and clinical studies of colorectal cancer, whereas the results are not encouraging. (biomedcentral.com)
Cancer stem cells (CSCs) (or tumor-initiating cells) are a new subpopulation that can self-renew and differentiate to produce malignant cells [ 9 ]. (hindawi.com)
HCC with stem cell features has a very bad prognosis [ 10 ]. (hindawi.com)

The crystal structure of this chimera reveals the interaction between alpha- and beta-catenin, and provides a basis for understanding adherens junction assembly. (nih.gov)

These cells divide and mature to form the different components of the hair follicle and the hair shaft. (medlineplus.gov)
Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. (thermofisher.cn)

5. beta-catenin is involved in N-cadherin-dependent adhesion, but not in canonical Wnt signaling in E2A-PBX1-positive B acute lymphoblastic leukemia cells. (nih.gov)

Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). (neobiotechnologies.com)
Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). (neobiotechnologies.com)

Elevation in expression and activity of β-catenin has been implicated in many cancers and associated with poor prognosis. (biomedcentral.com)
Conclusion: SOX9 expression is related to prognosis in patients with oesophageal squamous cell carcinoma, although it is not an independent prognostic factor. (iiarjournals.org)
CONCLUSION: In clear cell endometrial cancer, the presence of a definite admixed endometrioid or serous component did not correlate with a significant difference in prognosis. (bvsalud.org)

A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. (nih.gov)

Adhesion molecule expression and cytotoxicity in diacetyl exposed rat lungs. (cdc.gov)

In six human cancer cell lines, the inhibition of total and nuclear expression of β-catenin by MSeA was dose and time dependent. (biomedcentral.com)
This study demonstrates that β-catenin, a molecule associated with drug resistance, is a target of selenium and its inhibition is associated with increased multiple drugs cytotoxicity in various human cancers. (biomedcentral.com)
Both Pbl and ECT2 repress Wg/Wnt target gene expression in cultured Drosophila and human cells. (silverchair.com)
The eBioGoH3 antibody is cross-reactive to integrin alpha 6 on human, mouse and bovine cells. (thermofisher.com)
Applications Tested: This eBioGoH3 (GoH3) antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
Basal cell carcinoma is one of the most common human cancers, affecting some 2 million people a year in the US, according to the American Academy of Dermatology, and is thought to be mainly caused by exposure to ultraviolet light. (shu.edu)
SP cells were isolated from human umbilical cord MSCs (hUCMSCs) and human placenta MSCs (hPMSCs). (biomedcentral.com)
Tn + cells (LS174T-Tn + and HT-29-Tn + cells) and matching Tn − cells (LS174T-Tn − and HT-29-Tn − cells) were isolated from human colorectal cancer cell (CRC) lines LS174T and HT-29 by immune magnetic beads. (biomedcentral.com)

MUC1 also prevents the interaction of immune cells with receptors on the cancer cell surface through steric hindrance. (wikipedia.org)
Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. (embl.de)
The cylindrical structure features a positively charged grove, which presumably interacts with the acidic surfaces of the known interaction partners of beta-catenin. (embl.de)
A representative example of a 'druggable' 'hot spots' included specific topological features of the β -catenin interaction. (chemdiv.com)

Furthermore, we provide evidence that adhesion heterogeneity can explain the remarkable differences in adhesion receptor concentrations of epithelial and mesenchymal phenotypes observed during EMT and might drive early dissemination of tumour cells. (biomedcentral.com)
Tumour cell invasion and dissemination are accompanied by epithelial-mesenchymal transitions (EMT) of individual cells [ 4 ]. (biomedcentral.com)

The wingless ( wg ) gene, which encodes the primary fly Wnt, is expressed in a single row of epidermal cells in each segment and generates positional information across the segment (reviewed by Bejsovec, 2006 ). (silverchair.com)

Beta-catenin plays an important role in sticking cells together (cell adhesion) and in communication between cells. (nih.gov)
Among its many activities, beta-catenin appears to play an important role in the normal function of hair follicles, which are specialized structures in the skin where hair growth occurs. (nih.gov)
MUC1, also referred to as mammary-type mucin, has a role in the maintenance of the lumina of ductal epithelial cells, and is thought to have an inhibitory role in cell-cell and cell-stroma interactions and in cytotoxic immunity. (bmj.com)
Adhesion factors play a vital role in the process of mycoplasma infection and pathogenicity. (biomedcentral.com)
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. (lookformedical.com)
A pathological role of beta-catenin has been identified in pilomatrixoma (PTR), medulloblastoma (MDB), colorectal cancer (CRC), ovarian cancer, and tumor development. (thermofisher.cn)
β-catenin is a multipurpose and evolutionarily conserved molecule that plays a critical role by metazoans in a variety of processes in development and homeostasis. (chemdiv.com)

7. E-cadherin modulates Wnt-dependent transcription in colorectal cancer cells but does not alter Wnt-independent gene expression in fibroblasts. (nih.gov)
13. Focal adhesion kinase (FAK) expression and activation during lens development. (nih.gov)
In contrast, MUC2 is referred to as intestinal-type mucin because its expression is normally limited to goblet cells, where it contributes to the protective barrier function of these cells. (bmj.com)
In this study, we show that mono-(2-ethylhexyl) phthalate (MEHP) induces matrix metalloproteinase 2 (MMP2) expression in testicular embryonal carcinoma NT2/D1 cells but has no significant effect on MMP9 expression. (nih.gov)
NT2/D1 cells also have higher levels of MYC expression following MEHP treatment. (nih.gov)
Furthermore, we investigated genome-wide gene expression profiles of NT2/D1 cells following MEHP exposure at 0, 3, and 24 h. (nih.gov)
We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. (stowers.org)
Expression of each cluster's gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq. (stowers.org)
Violin plots show distribution of expression levels for Beta-catenin (SMED30019916) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
Expression of Beta-catenin (SMED30019916) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (stowers.org)
In the present study, the clinical significance of SOX9 expression in oesophageal squamous cell carcinoma was examined. (iiarjournals.org)
Materials and Methods: SOX9 expression in surgical specimens of primary tumours were immunohistochemically investigated in 175 patients with oesophageal squamous cell carcinomas. (iiarjournals.org)
In some necrotic foci in the mainstem bronchus epithelium, the normal thin linear staining of beta-catenin at intercellular junctions was replaced by more focal globular expression. (cdc.gov)
Detaching necrotic cells also often lost beta-catenin and e-cadherin expression. (cdc.gov)
During this study we found that frequency of stimulation influence the expression of Wnt-3a and Beta-catenin expression in a timely fashion while also being affected by the duration of the stimuli, together, it was also found that there is a threshold for both mechanical inputs which clearly mark a higher gene expression of WNT-3a and beta-catenin. (oatext.com)
CD49f expression has also been found on germinal center B cells. (thermofisher.com)

4. Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function. (nih.gov)
Three-dimensional (3D) cell culture in vitro is a powerful tool for investigating epithelial morphogenesis, physiology and disease, being readily accessible to microscopic inspection, chemical treatment and experimental manipulation. (nature.com)

2013. Targeting focal adhesion kinase in ER+/HER2+ breast cancer improves trastuzumab response . (cardiff.ac.uk)

CRISPR/Cas9 knockout of podocalyxin causes junctional organization defects in podocyte-like cells. (nature.com)

A slightly larger fragment, comprising residues 57-264, binds to beta-catenin. (nih.gov)

Catenina multifuncional que participa en la ADHESIÓN CELULAR y en la señalización nuclear. (bvsalud.org)

RR CC was named for its morphologic resemblance to pediatric malignant rhabdoid tumor (MRT) of the kidney, which is a highly aggressive tumor characterized by cells that resemble rhabdomyoblasts and by genetic alterations involving chromosome 22, particularly the hSNF5/INI1 gene on 22q11.2. (medscape.com)
Conventional epithelial cell lines, however, are lineage-restricted and lack genetic diversity. (nature.com)

This allows cancer cells which produce a large amount of MUC1 to concentrate growth factors near their receptors, increasing receptor activity and the growth of cancer cells. (wikipedia.org)
AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. (origene.com)
Cells propagated in vitro in special media conducive to their growth. (lookformedical.com)
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. (lookformedical.com)
Concealed disseminated cancer cells are asymptomatic and are thought to be growth-arrested in G0 to G1 of cell cycle and thus in a quiescent state during the freezing process. (researchsquare.com)

Deregulation of components involved in Wnt/β-catenin signaling has been implicated in a wide spectrum of diseases including a number of cancers and degenerative diseases. (chemdiv.com)

Fusion cells form E-cadherin contacts associated with a track that contains F-actin, microtubules, and Shot, a plakin that binds F-actin and microtubules. (biologists.com)

Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. (neobiotechnologies.com)

Here, we use a novel mathematical model to study how adhesion heterogeneity, influenced by intrinsic and extrinsic factors, affects the dissemination of tumour cells from an epithelial cell population. (biomedcentral.com)
Simulations of our mathematical model indicate profound effects of adhesion heterogeneity on tumour cell dissemination. (biomedcentral.com)
Accordingly, our findings explain how both an increase in intra-tumour adhesion heterogeneity and the loss of control through the local environment can promote tumour cell dissemination. (biomedcentral.com)
Before metastases form, tumour cells disseminate and migrate away from solid tumours to invade surrounding tissue [ 3 , 4 ]. (biomedcentral.com)
A better understanding of the general principles underlying the triggers of tumour cell dissemination is therefore a key step in developing effective cancer treatments. (biomedcentral.com)

ChemDiv's Inhibitors of beta-Catenin Signaling Library contains 8,000 compounds. (chemdiv.com)
ChemDiv proposes the new library of beta-catenin inhibitors/modulators. (chemdiv.com)

Anatomy38

Organisms7

Diseases12

Chemicals and Drugs132

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes44

Disciplines and Occupations1

Information Science3

CTNNB110

Alpha-catenin16

Protein41

Proliferation33

Pathway12

Differentiation7

Molecules4

Proteins9

Mediates3

Apoptosis6

Tumors9

Mutations4

Cytoplasm8

Independent of beta-catenin2

Signal transduction1

Regulate3

Nucleus2

Regulation9

Metastasis8

Cadherins1

Migration3

Cytoplasmic3

Tissues6

Cellular7

Tumor cells3

Genes2

Stabilization2

Armadillo3

Endothelial9

Mutation2

Cadherin-based1

Pathways3

Recombinant1

Intercellular adhesion1

Intracellular2

Stem17

Adherens junction1

Hair follicle2

Canonical1

Promotes2

Prognosis3

Participates1

Molecule expression1

Human8

Interaction4

Mesenchymal2

Wingless1

Role7

Expression16

Morphogenesis2

Focal1

Junctional1

Fragment1

Nuclear1

Genetic2

Growth5

Deregulation1

Binds1

Ductal1

Tumour5

Inhibitors2