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Cell Adhesion MoleculesCell AdhesionVascular Cell Adhesion Molecule-1Intercellular Adhesion Molecule-1Neural Cell Adhesion MoleculesCell Adhesion Molecules, NeuronalTissue AdhesionsFocal AdhesionsNeural Cell Adhesion Molecule L1E-SelectinLeukocytesIntegrinsLeukocyte RollingCell MovementEndothelium, VascularFocal Adhesion Kinase 1Cells, CulturedFocal Adhesion Protein-Tyrosine KinasesActivated-Leukocyte Cell Adhesion MoleculeBacterial AdhesionCadherinsP-SelectinLymphocyte Function-Associated Antigen-1FibronectinsAntigens, CD18Integrin alpha4beta1Molecular Sequence DataAntigens, CDCell LineCell AggregationJunctional Adhesion MoleculesAntibodies, MonoclonalSignal TransductionAmino Acid SequenceAntigens, CD31Chemotaxis, LeukocyteL-SelectinProtein BindingReceptors, Lymphocyte HomingAntigens, CD29Endothelial CellsNeutrophilsLeukocyte L1 Antigen ComplexLeukocyte CountUmbilical VeinsMice, Inbred C57BLIntegrin alpha4Flow CytometryPaxillinSelectinsMacrophage-1 AntigenCell CommunicationMembrane GlycoproteinsMonocytesExtracellular MatrixImmunohistochemistryRNA, MessengerVenulesTransfectionTumor Necrosis Factor-alphaMembrane ProteinsCytoskeletal ProteinsCytoskeletonInflammationLamininSialic AcidsBase SequenceAntigens, SurfaceImmunoglobulinsReceptors, Leukocyte-AdhesionProtein Structure, TertiaryPlatelet AdhesivenessTumor Cells, CulturedActinsMice, KnockoutRecombinant ProteinsCell MembraneUp-RegulationVinculinEpithelial CellsPhosphorylationLigandsBinding SitesGene Expression RegulationFluorescent Antibody TechniqueCell Line, TumorReceptors, Very Late AntigenAntigens, CD146Blotting, WesternIntercellular JunctionsOligopeptidesTime FactorsRecombinant Fusion ProteinsMicroscopy, FluorescenceT-LymphocytesModels, BiologicalAdhesivenessAntigens, CD44Cell Adhesion Molecules, Neuron-GliaCricetinae
Targeting activated leukocyte cell adhesionNeural cell adhEndothelial cellsALCAMMigrationCausing leukocyte adhesion dInflammatoryReceptorsIntercellularLymphocyteCytokinesInflammationBiolMolecularInteractionsProteinRegulationMediatesNCAMAntigenCD166PlateletsIntegrinsHematopoieticImmuneDifferentiationRolesIntegrinPathogenesisSelectinsMonoclonal antibodyDeficiencyGeneICAMBlood vesselsExpressionProliferationDeficientInteractionPeripheral blood mononuclear cellsTissuesAntibodyRecruitmentGlycoproteinsProteinsCD56MembraneNeutrophilsLymphomaGenesRegulatesApoptosisLymphatic vesselsMetastasisMiceSurface
Targeting activated leukocyte cell adhesion1
  • A novel molecular magnetic resonance imaging agent targeting activated leukocyte cell adhesion molecule as demonstrated in mouse brain metastasis models. (ox.ac.uk)
Neural cell adh6
  • The CD56 (NCAM16.2) antibody recognizes an extracellular immunoglobulin-like domain common to three molecular weight forms-120, 140, and 180 kilodaltons (kDa)-of the neural cell adhesion molecule (NCAM). (bdbiosciences.com)
  • Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing. (bdbiosciences.com)
  • Molecular and functional analysis of human natural killer cell-associated neural cell adhesion molecule (N-CAM/CD56). (bdbiosciences.com)
  • Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule. (bdbiosciences.com)
  • Polysialic acid (polySia) is a large glycan with restricted expression, typically found attached to the protein scaffold neural cell adhesion molecule (NCAM). (ca.gov)
  • Since leucocyte-endothelial cell interactions involve various adhesion receptors we have analysed the expression and distribution pattern of the neural cell adhesion molecule (NCAM), the intercellular adhesion molecule-1 (ICAM-1), the vascular cell adhesion molecule-1 (VCAM-1), the endothelial leucocyte adhesion molecule-1 (ELAM-1), and the cluster of differentiation antigen-44 (CD44) on flat preparations of normal and organ-cultured HCECs. (bmj.com)
Endothelial cells18
ALCAM20
  • Glycosylation-dependent binding of galectin-8 to activated leukocyte cell adhesion molecule (ALCAM/CD166) promotes its surface segregation on breast cancer cells. (bvsalud.org)
  • ALCAM is a member of the immunoglobulin superfamily that promotes homophilic and heterophilic cell - cell interactions . (bvsalud.org)
  • We performed binding assays by surface plasmon resonance to study the interaction between Gal-8 and the recombinant glycosylated ALCAM ectodomain or endogenous ALCAM from MDA-MB-231 breast cancer cells . (bvsalud.org)
  • We also analyzed the binding of ALCAM -silenced or control breast cancer cells to immobilized Gal-8 by SPR. (bvsalud.org)
  • We showed that recombinant glycosylated ALCAM and endogenous ALCAM from breast carcinoma cells physically interacted with Gal-8 in a glycosylation -dependent fashion displaying a differential behavior compared to non-glycosylated ALCAM . (bvsalud.org)
  • Moreover, ALCAM -silenced breast cancer cells exhibited reduced binding to Gal-8 relative to control cells . (bvsalud.org)
  • Importantly, exogenously added Gal-8 provoked ALCAM segregation, probably trapping this adhesion molecule at the surface of breast cancer cells . (bvsalud.org)
  • Our data indicate that Gal-8 interacts with ALCAM at the surface of breast cancer cells through glycosylation -dependent mechanisms. (bvsalud.org)
  • A novel heterophilic interaction between ALCAM and Gal-8 is demonstrated here, suggesting its physiologic relevance in the biology of breast cancer cells . (bvsalud.org)
  • Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166) is a cell-cell adhesion protein conferring heterotypic and homotypic interactions between cells of the same type and different types. (cardiff.ac.uk)
  • Specifically, we studied whether ALCAM acts as both a 'seed' receptor in these tumour cells and a 'soil' receptor in peritoneal mesothelial cells during cancer metastasis. (cardiff.ac.uk)
  • In addition, cancer cells of gastric and pancreatic origins were used to create cell models with decreased or increased levels of ALCAM expression by genetic knocking down or overexpression, respectively. (cardiff.ac.uk)
  • Human peritoneal mesothelial cells were also genetically transfected to generate cell models with different profiles of ALCAM expression. (cardiff.ac.uk)
  • These cell models were used in the tumour-mesothelial interaction assay to assess if and how the interaction was influenced by ALCAM. (cardiff.ac.uk)
  • ALCAM knockdown of the mesothelial cell line MET5A rendered the cells with reduced interaction with both gastric cancer cells and pancreatic cancer cells. (cardiff.ac.uk)
  • Likewise, levels of ALCAM in both human gastric and pancreatic cancer cells were also a determining factor for their adhesiveness to mesothelial cells, a process that was likely to be triggered the phosphorylation of the SRC kinase. (cardiff.ac.uk)
  • A soluble ALCAM (sALCAM) was found to be able to inhibit the adhesiveness between cancer cells and mesothelial cells, mechanistically behaving like a SRC kinase inhibitor. (cardiff.ac.uk)
  • Upregulation of endothelial ALCAM (activated leukocyte cell adhesion molecule) is a key element for leukocyte recruitment in neurological disease. (ox.ac.uk)
  • Subsequently, in a proof-of-concept study, mouse models of brain metastasis were induced by intracardial injection of brain-tropic human breast carcinoma, lung adenocarcinoma or melanoma cells to upregulate endothelial ALCAM. (ox.ac.uk)
  • The study showed that blocking ALCAM in mice lessens the flow of B cells to the brain and slows the progression of MS. (medicalnewstoday.com)
Migration16
  • The process of metastasis is the consequence of migration of melanoma cells from the primary lesion, to locoregional and distant body sites via the lymphatic circulation and the bloodstream. (hindawi.com)
  • Similarly to other inflammatory reactions, one critical aspect of granuloma formation is leukocyte migration dependent on the expression of adhesion molecules and cytokines [ 14 , 18 , 19 ]. (hindawi.com)
  • Hydrocortisone decreases inflammation by suppressing migration of PMN leukocytes and reversing increased capillary permeability. (medscape.com)
  • Methylprednisolone exerts anti-inflammatory effects by suppressing the migration of polymorphonuclear leukocytes and reversing increased capillary permeability. (medscape.com)
  • Keeping B cells outside of the brain by blocking their migration but retaining them in the blood could reduce MS symptoms and progression - without the infectious side effects because they are not depleted from the rest of the body. (medicalnewstoday.com)
  • L1CAM plays a role in neural development, axon guidance, and cell migration. (pharmiweb.com)
  • Next, the effects of miR-637 on glioma cell migration and invasion were determined by using the transwell assay. (scirp.org)
  • In addition, miR-637 suppressed glioma cell migration and invasion. (scirp.org)
  • Consequently, we aimed to assess miR-637 expression in gliomas to determine the effects of miR-637 on glioma cell migration and invasion, as well as to explore the possible signaling pathways involved. (scirp.org)
  • This work uses a model of experimental T1DM to investigate the intervention of insulin in a model of murine PCM induced by Paracoccidioides brasiliensis , analyzing the process of cell migration (adhesion molecules expression, leukocyte phenotyping), molecular mechanisms (production and secretion of cytokines), intracellular mechanisms (signaling pathways) and phagocytic and microbicidal activities in alveolar macrophages. (usp.br)
  • The binding of integrin receptors to extraceullular proteins permits cell adhesion and migration during development, wound healing, and inflammation. (upstate.edu)
  • First, how does the leukocyte utilize these receptors to mediate selective adhesion and migration through complex extracellular tissues? (upstate.edu)
  • CX3CR1 mediates leukocyte migration and adhesion. (prosci-inc.com)
  • CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. (thermofisher.com)
  • A homing receptor-bearing cortical thymocyte subset: implications for thymus cell migration and the nature of cortisone-resistant thymocytes. (southernbiotech.com)
  • Defective migration of monocyte-derived dendritic cells in LAD-1 immunodeficiency. (lu.se)
Causing leukocyte adhesion d2
  • A novel point mutation in CD18 causing leukocyte adhesion deficiency in a Chinese patient. (lu.se)
  • Two Novel Frame Shift, Recurrent and De Novo Mutations in the ITGB2 (CD18) Gene Causing Leukocyte Adhesion Deficiency in a Highly Inbred North African Population. (lu.se)
Inflammatory12
  • Dr. Gubatan's research is focused on translational studies using single-cell genomics to understand mechanisms of biologic therapy failure, elucidate the role of host immune and gut microbiome interactions in the pathogenesis of inflammatory bowel disease (IBD), and develop precision medicine strategies to improve outcomes in patients with IBD. (stanford.edu)
  • In addition to inflammatory cell infiltration in the bronchial wall 1 , histological analysis of endobronchial biopsy specimens and new methods of blood flow measurements have revealed prominent alterations of the tracheobronchial (airway) vasculature in patients with asthma. (ersjournals.com)
  • The inflammatory process in asthma involves the increased expression of various pro-inflammatory chemokines, cytokines, growth factors, lipid mediators, adhesion molecules, enzymes, and receptors for the same inflammatory mediators 21 . (ersjournals.com)
  • The Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis found 16 significant regulated pathways in imDCs and 10 significant regulated pathways in mDCs, including the phagosome, cell adhesion signaling pathway, and inflammatory mediator regulation of TRP channels pathway. (frontiersin.org)
  • Current understanding of histone post-translational modifications (histone modifications) across immune cell types in patients with inflammatory bowel disease (IBD) during remission and flare is limited. (stanford.edu)
  • Metalloendopeptidase ADAM-like Decysin 1 (ADAMDEC1) in Colonic Subepithelial PDGFRalpha+ Cells Is a New Marker for Inflammatory Bowel Disease. (stanford.edu)
  • Pathogen-associated molecular patterns released by infecting organisms not only bind immune receptors on inflammatory cells but also bind receptors on cells in the heart ( 8 ). (frontiersin.org)
  • The protein intercellular adhesion molecule 3 (ICAM-3) functions as a receptor for LFA-1 (leukocyte function-associated antigen-1) and mediates adhesive interactions of leukocyte cell surface adhesion molecules in inflammatory and immune response. (sigmaaldrich.com)
  • Herein we show the expression of polySia on hematopoietic progenitor cells, and demonstrate a role for this glycan in immune response using both acute inflammatory and tumor models. (ca.gov)
  • Actin Cytoskeletal Dynamics in the leukocyte inflammatory phenotype. (upstate.edu)
  • White blood cells, or leukocytes, are extremely dependent upon integrin receptor recognition of matrix proteins in order to exit the vasculature and resolve inflammatory events within the tissues. (upstate.edu)
  • TNF-a then induces the expression of leukocyte adhesion molecules upon proximal septal capillary endothelium resulting in the recruitment of inflammatory leukocytes to the site. (cdc.gov)
Receptors3
  • LECs can modulate dendritic cell function, present antigens to T cells on MHC class I and MHC class II molecules, and express immunomodulatory cytokines and receptors, which suggests that their roles in adaptive immunity are far more extensive than previously realized. (jci.org)
  • Recently it has been recognized that integrin receptors not only provide a physical link between cells and substrates, but also transduce signals to the cell which affect cell behavior. (upstate.edu)
  • Second, how does the ligation of integrin receptors affect leukocyte behavior? (upstate.edu)
Intercellular2
  • The gene ICAM3 (intercellular adhesion molecule 3) encodes type I membrane glycoprotein that belongs to the immunoglobulin (ig) superfamily. (sigmaaldrich.com)
  • Therefore, the aim of the present work was to evaluate the effect of NAC on interleukin-8 (IL-8) and matrix metalloproteinase-9 (MMP-9) production as well as intercellular cell adhesion molecule-1 (ICAM-1) expression by BAL cells from interstitial lung diseases. (nih.gov)
Lymphocyte8
  • Ledbetter JA, Evans RL, Lipinski M, Cunningham-Rundles C, Good RA, Herzenberg LA. Evolutionary conservation of surface molecules that distinguish T lymphocyte helper/inducer and cytotoxic/suppressor subpopulations in mouse and man. (bdbiosciences.com)
  • It may also function in lymphocyte activation, as well as in adhesion. (sigmaaldrich.com)
  • The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. (wikidoc.org)
  • Aruffo A, Melnick MB, Linsley PS, Seed B. The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins. (hcdm.org)
  • This member of the selectin family of cell adhesion molecules appears to be required for lymphocyte homing to peripheral lymph nodes and for leukocyte extravasation at sites of inflammation. (southernbiotech.com)
  • The monoclonal antibody MEL-14 blocks in vitro binding of lymphocytes to peripheral lymph node HEV and inhibits in vivo lymphocyte extravasation into peripheral lymph nodes and the late stages of leukocyte rolling. (southernbiotech.com)
  • A novel CD18 genomic deletion in a patient with severe leucocyte adhesion deficiency: a possible CD2/lymphocyte function-associated antigen-1 functional association in humans. (lu.se)
  • Leukocyte adhesion deficiency results from an adhesion molecule defect that causes granulocyte and lymphocyte dysfunction and recurrent soft-tissue infections. (msdmanuals.com)
Cytokines1
  • LECs are presumably the first cells that come into direct contact with peripheral antigens, cytokines, danger signals, and immune cells travelling from peripheral tissues to lymph nodes. (jci.org)
Inflammation4
  • Corticosteroids are immunosuppressive and affect the replication, movement, and activity of virtually all cells involved with inflammation. (medscape.com)
  • Defining integrin biology at a molecular level, including delineation of required signalling molecules, will produce additional targets for pharmacologic intervention in diseases as diverse as cancers and inflammation. (upstate.edu)
  • The laboratory utilizes techniques ranging from molecular biology to whole animal inflammation models, with an emphasis on cell biology and protein biochemistry. (upstate.edu)
  • However, inflammation causes the expression of cell adhesion molecules (CAM) such as P-selectin on the surface of the blood vessel wall. (wikidoc.org)
Biol4
Molecular3
  • SELE Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 541 amino acids (22-556 a.a) and having a molecular mass of 59.4kDa. (prospecbio.com)
  • Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils, lymphocytes, and other leukocytes. (southernbiotech.com)
  • Neutrophil function and molecular analysis in severe leukocyte adhesion deficiency type I without separation delay of the umbilical cord. (lu.se)
Interactions8
  • CD166 plays an important role in mediating adhesion interactions between thymic epithelial cells and CD6+ cells during intrathymic T cell development. (wikipedia.org)
  • While we particularly focus on LEC interactions with DCs and T cells, we also highlight features that support immune regulation, including the structure and function of lymphatic vessels and the compartmentalization of the LN stroma, which help control the manner in which LECs can interface with immune cells. (jci.org)
  • The lymphatic vessels and secondary lymphoid organs (SLOs) are arranged in a manner that optimizes interactions among antigens, APCs, and innate and adaptive effector cells. (jci.org)
  • Cell adhesion molecules are a diverse group of proteins that play a crucial role in mediating cell-to-cell interactions and cell-to-extracellular matrix interactions. (pharmiweb.com)
  • Several Ig-superfamily CADMs are crucial for immune cell interactions. (pharmiweb.com)
  • The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. (wikidoc.org)
  • N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. (thermofisher.com)
  • these glycoproteins facilitate cellular interactions, cell attachment to blood vessel walls, cell movement, and interaction with complement fragments. (msdmanuals.com)
Protein9
  • Gal-8 is a "tandem-repeat"-type galectin , known as a matricellular protein involved in cell adhesion . (bvsalud.org)
  • citation needed] CD166 protein expression is reported to be upregulated in a cell line deriving from a metastasizing melanoma. (wikipedia.org)
  • Oral tolerance is a T-cell-mediated phenomenon described as the inhibition of immune responsiveness to a protein previously contacted by the oral route [ 1 , 2 ]. (hindawi.com)
  • ADAMDEC1 protein was mainly released from PDGFRalpha+ cells and accumulated in the mucosal layer lamina propria space near the epithelial basement membrane. (stanford.edu)
  • Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells, which are added to human E-Seletin/CD62E coated plates 2ug/ml. (prospecbio.com)
  • The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1. (prosci-inc.com)
  • CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. (thermofisher.com)
  • SLP-76 7 , T cell-specific adaptor protein 8 , TCR/CD3 complex 9 and Syntenin-1. (hcdm.org)
  • Hem CD, Ekornhol M, Granum S, Sundvold-Gjerstad V, Spurkland A. CD6 and Linker of Activated T Cells are Potential Interaction Partners for T Cell-Specific Adaptor Protein. (hcdm.org)
Regulation4
  • Cell adhesion molecules in the regulation of animal form and tissue pattern. (bdbiosciences.com)
  • This is the first demonstration of polySia expression and regulation on myeloid cells, and the results in animal models suggest a role for polySia in immune regulation. (ca.gov)
  • moreover, normal cell regulation can be disrupted by tumor-suppressive or oncogenic miRNAs. (scirp.org)
  • Up-regulation of leukocyte CXCR4 expression by sulfatide: an L-selectin-dependent pathway on CD4 + T cells. (southernbiotech.com)
Mediates1
  • ICAM-3 mediates the adhesion of resting T lymphocytes to LFA-1 and participates in the initiation of immune responses. (sigmaaldrich.com)
NCAM3
  • The CD56 antibody, clone NCAM16.2, is derived from the hybridization of P3X-63- Ag8.653 mouse cells with lymph nodes from BALB/c mice immunized with immunoaffinity-enriched adult human brain NCAM. (bdbiosciences.com)
  • Specifically, we found that human NK cells modulate expression of NCAM and the degree of polymerization of its polySia glycans according to activation state. (ca.gov)
  • This contrasts with the mouse, where polySia and NCAM expression are restricted to multipotent hematopoietic progenitors and cells developing along a myeloid lineage. (ca.gov)
Antigen5
  • Immunologists recognized the importance of lymphatic vessels as channels for leukocyte trafficking from peripheral sites to their draining LNs ( 4 - 6 ), and as conduits for soluble antigens that can be taken up directly by LN-resident B cells and immature DCs ( 7 - 10 ), which help regulate the kinetics of antigen presentation. (jci.org)
  • Dendritic cells (DCs), which are the most important antigen-presenting cells (APCs) that send signals to the T cells, mainly participate in the pathogenesis of many diseases with immunoregulatory mechanisms, such as AR. (frontiersin.org)
  • The CD45 antibody recognizes a 180- to 220-kDa human leucocyte antigen that is a member of the leucocyte common antigen (LCA) family. (bdbiosciences.com)
  • Interleukin 2 activation of natural killer cells rapidly induces the expression and phosphorylation of the Leu-23 activation antigen. (bdbiosciences.com)
  • The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes. (bdbiosciences.com)
CD1661
  • citation needed] Recently, CD166 has also been used as a potential cancer stem cell marker. (wikipedia.org)
Platelets1
  • As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. (wikidoc.org)
Integrins4
  • Signaling through the β2 integrins triggers the transport of the attached leukocyte across the blood vessel wall to the site of infection or injury. (medlineplus.gov)
  • ITGB2 gene mutations that cause leukocyte adhesion deficiency type 1 lead to the production of a β2 subunit that cannot bind with other subunits to form β2 integrins. (medlineplus.gov)
  • Leukocytes that lack these integrins cannot attach to the blood vessel wall or cross the vessel wall to contribute to the immune response. (medlineplus.gov)
  • Characterization of four CD18 mutants in leucocyte adhesion deficient (LAD) patients with differential capacities to support expression and function of the CD11/CD18 integrins LFA-1, Mac-1 and p150,95. (lu.se)
Hematopoietic3
  • They had a higher proportion of less differentiated CD34 + hematopoietic progenitors, and a subset of CD56 bright NK cells and γδ T cells characterized by distinct histone modifications associated with the gene transcription. (stanford.edu)
  • CD6 is expressed in T cells 1 , medullary thymocytes 1 , a subset of NK cells 2 , some hematopoietic progenitors 3 and a small group of B lymphocytes. (hcdm.org)
  • Type 3 is caused by mutations in the FERMT3 gene (11q13.1), which encodes kindlin-3 in hematopoietic cells. (msdmanuals.com)
Immune11
  • Leukocyte adhesion deficiency type 1 is a disorder that causes the immune system to malfunction, resulting in a form of immunodeficiency. (medlineplus.gov)
  • It may decrease proliferation of immune cells, which results in lower autoimmune activity. (medscape.com)
  • Cyclosporine is a cyclic polypeptide that suppresses some humoral immunity and, to a greater extent, cell-mediated immune reactions such as delayed hypersensitivity, allograft rejection, experimental allergic encephalomyelitis, and graft versus host disease for a variety of organs. (medscape.com)
  • Mass-cytometry-based quantitation of global histone post-translational modifications at single-cell resolution across peripheral immune cells in IBD. (stanford.edu)
  • We used epigenetic profiling by time-of-flight (EpiTOF) to investigate changes in histone modifications within peripheral blood mononuclear cells from IBD patients.We discovered substantial heterogeneity in histone modifications across multiple immune cell types in IBD patients. (stanford.edu)
  • CD14+ monocytes from IBD patients had significantly decreased cleaved H3T22, suggesting they were epigenetically primed for macrophage differentiation.We describe the first systems-level quantification of histone modifications across immune cells from IBD patients at a single-cell resolution revealing the increased epigenetic heterogeneity that is not possible with traditional ChIP-seq profiling. (stanford.edu)
  • While earlier work characterized PDAC as an immunologically privileged tumor poorly recognized by the immune system, recent studies revealed the important and nuanced roles of immune cells in the pathogenesis of PDAC. (stanford.edu)
  • These molecules are essential for embryonic development, wound healing, immune cell recognition, and many other physiological functions. (pharmiweb.com)
  • Among the superfamily of cell adhesion molecules, in this article, we mainly focus on Ig-Superfamily CADMs: the members of the Immunoglobulin superfamily of cell adhesion molecules, which play diverse roles in immune responses, neural development, and cell signaling. (pharmiweb.com)
  • Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses. (ca.gov)
  • In mice it seems to be an immune factor regulating T-cell checkpoints , and it could be a target for future checkpoint inhibitor anti-cancer drugs. (wikidoc.org)
Differentiation2
  • When either the sphere-forming system or the adherent system is used, some of the cancer cells can be propagated but other cells are lost because of cell death/apoptosis or differentiation. (nature.com)
  • Leucocyte typing III : white cell differentiation antigens. (bdbiosciences.com)
Roles1
Integrin3
  • CD18, in association with integrin α chain CD11a, CD11b, and CD11c forms LFA-1, Mac-1, and α X β 2 , respectively, and plays an important role in leukocyte adhesion. (biolegend.com)
  • Our laboratory studies two aspects of leukocyte integrin biology. (upstate.edu)
  • Chandhoke, S.K. and Blystone, S.D. Beta-3 integrin phosphorylation is essential for Arp3 organization into leukocyte avb3 -vitronectin adhesions. (upstate.edu)
Pathogenesis1
  • Therefore, functionally analyzing the individual types of the heterogeneous cells and determining their role in tumor pathogenesis are critical. (nature.com)
Selectins1
Monoclonal antibody1
  • Description: The WM59 monoclonal antibody reacts with human CD31, also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1) and gpIIa. (thermofisher.com)
Deficiency23
  • Starting from birth, people with leukocyte adhesion deficiency type 1 develop serious bacterial and fungal infections. (medlineplus.gov)
  • One of the first signs of leukocyte adhesion deficiency type 1 is a delay in the detachment of the umbilical cord stump after birth. (medlineplus.gov)
  • but, in infants with leukocyte adhesion deficiency type 1, this separation usually occurs at three weeks or later. (medlineplus.gov)
  • In leukocyte adhesion deficiency type 1, bacterial and fungal infections most commonly occur on the skin and mucous membranes such as the moist lining of the nose and mouth. (medlineplus.gov)
  • A hallmark of leukocyte adhesion deficiency type 1 is the lack of pus formation at the sites of infection. (medlineplus.gov)
  • Life expectancy in individuals with leukocyte adhesion deficiency type 1 is often severely shortened. (medlineplus.gov)
  • Leukocyte adhesion deficiency type 1 is estimated to occur in 1 per million people worldwide. (medlineplus.gov)
  • Mutations in the ITGB2 gene cause leukocyte adhesion deficiency type 1. (medlineplus.gov)
  • Cox DP, Weathers DR. Leukocyte adhesion deficiency type 1: an important consideration in the clinical differential diagnosis of prepubertal periodontitis. (medlineplus.gov)
  • Deficiency Validation (Figure 15): CX3CR1+ cells detected by anti-CX3CR1 antibodies is localized in vascular wall of CX3CR1 + /gfp mice, but not in CX3CR1 gfp/gfp mice, where cells remained in perivascular region. (prosci-inc.com)
  • A novel 3' splice-site mutation and a novel gross deletion in leukocyte adhesion deficiency (LAD)-1. (lu.se)
  • The effect of gentamicin-induced readthrough on a novel premature termination codon of CD18 leukocyte adhesion deficiency patients. (lu.se)
  • Characterization of 11 new cases of leukocyte adhesion deficiency type 1 with seven novel mutations in the ITGB2 gene. (lu.se)
  • ITGB2 mutation combined with deleted ring 21 chromosome in a child with leukocyte adhesion deficiency. (lu.se)
  • Reversion mutations in patients with leukocyte adhesion deficiency type-1 (LAD-1). (lu.se)
  • Functional characterization of natural killer cells in type I leukocyte adhesion deficiency. (lu.se)
  • Somatic revertant mosaicism in a patient with leukocyte adhesion deficiency type 1. (lu.se)
  • Unique CD18 mutations involving a deletion in the extracellular stalk region and a major truncation of the cytoplasmic domain in a patient with leukocyte adhesion deficiency type 1. (lu.se)
  • Chemotaxis of non-compressed blood polymorphonuclear leukocytes from an adolescent with severe leukocyte adhesion deficiency. (lu.se)
  • Genetic analysis of patients with leukocyte adhesion deficiency: genomic sequencing reveals otherwise undetectable mutations. (lu.se)
  • Nonopsonic phagocytosis of Pseudomonas aeruginoas: insights from an infant with leukocyte adhesion deficiency. (lu.se)
  • Manifestations of leukocyte adhesion deficiency usually begin in infancy. (msdmanuals.com)
  • Diagnosis of leukocyte adhesion deficiency is by detecting absence or severe deficiency of adhesive glycoproteins on the surface of WBCs using monoclonal antibodies (eg, anti-CD11, anti-CD18) and flow cytometry. (msdmanuals.com)
Gene1
  • which means both copies of the gene in each cell have mutations. (medlineplus.gov)
ICAM1
  • Upregulation of ICAM-1 highlights an underlying mechanism for leucocyte influx, and could also explain the predisposition to respiratory tract viral infections following NO 2 exposure since ICAM-1 is a major receptor for rhino and respiratory syncytial viruses. (bmj.com)
Blood vessels2
  • Traditionally, microcirculatory physiologists studied the essential transport functions of lymphatic vessels in removing fluid, molecules, and cells after leaking from blood vessels in the periphery and before returning them to the blood circulation. (jci.org)
  • PSGL-1 is expressed on all white blood cells and plays an important role in the recruitment of white blood cells into inflamed tissue: White blood cells normally do not interact with the endothelium of blood vessels. (wikidoc.org)
Expression5
  • The expression of biomarkers can be detected intracellularly or on the cell membrane of melanoma cells or noncancer cells in association with the melanoma. (hindawi.com)
  • The objective of this study is to explore the long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) expression profiles of monocyte-derived dendritic cells (DCs) obtained from peripheral blood mononuclear cells (PBMCs). (frontiersin.org)
  • We have recently found abundant and selective expression of Adamdec1 in colonic mucosal PDGFRalpha+ cells. (stanford.edu)
  • Expression of CD62L on lymphocytes and neutrophils is rapidly down-regulated upon cell activation and the level of CD62L expression, along with other markers, distinguishes naive T cells from effector/memory T cells. (southernbiotech.com)
  • Iron-containing particles have been proposed as a mechanism of introducing unregulated iron into cells, and soluble iron has been shown to induce the expression ofTNF-a in Kupffer cells, which was preceded by an increase in hydroxyl radicals. (cdc.gov)
Proliferation2
Deficient1
Interaction3
  • Here, we analyzed the physical interaction between both molecules in breast cancer cells and the functional relevance of this phenomenon. (bvsalud.org)
  • Homotypic interaction of CD31 is important in adhesion, cell-cell and cell-matrix interaction, and signal transduction. (thermofisher.com)
  • This interaction results in "rolling" of the white blood cell on the endothelial cell surface followed by stable adhesion and transmigration of the white blood cell into the inflamed tissue. (wikidoc.org)
Peripheral blood mononuclear cells2
  • The peripheral blood mononuclear cells (PBMCs) have a round nucleus ( Delves, 2016 ). (frontiersin.org)
  • The CD45 antibody, clone 2D1, is derived from hybridization of NS-1 mouse myeloma cells with spleen cells from BALB/c mice immunized with human peripheral blood mononuclear cells (PBMCs). (bdbiosciences.com)
Tissues3
  • When we placed dissociated glioma tissues on uncoated culture dishes, some cells formed sphere-like aggregates, whereas other cells grew out and extended cellular processes ( Fig. 1a ). (nature.com)
  • Ig-superfamily CADMs are involved in mediating cell-to-cell adhesion, helping cells stick together and form tissues and organs. (pharmiweb.com)
  • CX3CR1 is expressed in a variety of human tissues and cell lines. (prosci-inc.com)
Antibody3
  • The CD69 antibody, clone L78, is derived from hybridization of Sp2/0-Ag14 mouse myeloma cells with lymph node cells from BALB/c mice immunized with a CD8+ alloantigen-directed CTL cell line. (bdbiosciences.com)
  • Applications Tested: The WM-59 (WM59) antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
  • A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. (thermofisher.com)
Recruitment1
  • CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76. (hcdm.org)
Glycoproteins1
  • E-selectin (SELE) is a part of a family of divalent cation-dependent carbohydrate-binding glycoproteins or adhesion molecules. (prospecbio.com)
Proteins1
  • Some tumor suppressor proteins are involved in maintaining cell adhesion, preventing cells from breaking away and spreading to other parts of the body (metastasis). (pharmiweb.com)
CD561
  • The subset of CD56 bright NK cells had increased several histone acetylations. (stanford.edu)
Membrane1
  • Gimferrer I, Farnós M, Calvo M, Mittelbrunn M, Enrich C, Sánchez-Madrid F, Vives J, Lozano F. The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells. (hcdm.org)
Neutrophils1
Lymphoma5
  • Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
  • Early patch-stage cutaneous T-cell lymphoma. (medscape.com)
  • Related articles include Cutaneous B-Cell Lymphoma and Cutaneous Pseudolymphoma . (medscape.com)
  • Among the changes to CTCL classification were the addition of primary cutaneous acral CD8 + T-cell lymphoma as a new provisional entity. (medscape.com)
  • Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
Genes1
  • Tumor suppressor genes can promote cellular senescence, a state in which cells stop dividing, preventing the replication of damaged DNA. (pharmiweb.com)
Regulates1
  • 7. Diamant E, Keren Z, Melamed D. CD19 regulates positive selection and maturation in B lymphopoiesis: lack of CD19 imposes developmental arrest of immature B cells and consequential stimulation of receptor editing. (southernbiotech.com)
Apoptosis1
  • They can trigger apoptosis, a process of programmed cell death, when a cell becomes irreparably damaged or poses a risk of becoming cancerous. (pharmiweb.com)
Lymphatic vessels1
  • The process of metastasis involves the spread of neoplastic cells to locoregional or distant body sites via lymphatic vessels and/or bloodstream. (hindawi.com)
Metastasis2
  • It acts as not only a potential peritoneal 'soil' receptor of tumour seeding but also a 'soil' receptor in peritoneal mesothelial cells during cancer metastasis. (cardiff.ac.uk)
  • Dysregulation of these molecules can lead to various diseases, including cancer metastasis, autoimmune disorders, and developmental abnormalities. (pharmiweb.com)
Mice1
  • To investigate whether leukocyte-expressed PSGL-1 is mediating L-selectin-dependent rolling, we reconstituted lethally irradiated wild-type mice with PSGL-1 −/− bone marrow cells. (rupress.org)
Surface3