Cell acute. Medical search. Frequent questions

T-cell acute lymphoblastic leukemia (T-ALL) is a type of acute lymphoblastic leukemia with aggressive malignant neoplasm of the bone marrow. (wikipedia.org)
Acute lymphoblastic leukemia (ALL) is a condition where immature white blood cells accumulate in the bone marrow, subsequently crowding out normal white blood cells and create build-up in the liver, spleen, and lymph nodes. (wikipedia.org)
LncRNA NALT interaction with NOTCH1 promoted cell proliferation in pediatric T cell acute lymphoblastic leukemia. (nih.gov)
Lymphocyte subpopulations were studied in 28 children with acute lymphoblastic leukaemia at different stages of the disease. (karger.com)
A rare case of T cell acute lymphoblastic leukemia presenting with loss of vision, parotid swelling, hematuria and acute renal failure has been presented in a 40-year-old male. (scirp.org)
Acute T cell Lymphoblastic Leukemia should also be kept in differential diagnosis of hematuria, acute renal failure and loss of vision. (scirp.org)
N. Gilboa, G. M. Lum and R. E. Urizar, "Early Renal Involvement in Acute Lymphoblastic Leukemia and Non-Hodgkin's Lymphoma in Children," Journal of Urology, Vol. 129, No. 2, 1983, pp. 364-367. (scirp.org)
Acute lymphoblastic leukemia (ALL) is the most common malignancy in children, with a male predominance. (sfu.ca)
We present a case of a 7-month-old Pakistani male that presented with fever and cough and was subsequently diagnosed with T cell acute lymphoblastic leukemia. (sfu.ca)
Obecatagene autoleucel also appears to result in a high rate of minimal residual disease negativity in a population of patients with relapsed/refractory B-cell acute lymphoblastic leukemia. (cancernetwork.com)
The global T-cell acute lymphoblastic leukemia market is driven by rise in prevalence of T-cell acute lymphoblastic leukemia. (transparencymarketresearch.com)
T-cell acute lymphoblastic leukemia (T-ALL) is a type of acute lymphoblastic leukemia, with features similar to lymphoma. (transparencymarketresearch.com)
Rise in prevalence of T-ALL and rapid technological advancements boost the global T-cell acute lymphoblastic leukemia market. (transparencymarketresearch.com)
According to the American Society of Clinical Oncology (ASCO), T-cell acute lymphoblastic leukemia accounted for 15% to 20% of all acute lymphoblastic leukemia. (transparencymarketresearch.com)
According to a recent study, in 2017, nearly 5,970 cases of acute lymphoblastic leukemia (ALL) were reported in the U.S. About 4 in 10 cases were in adults. (transparencymarketresearch.com)
Moreover, increase in health care expenditure and rise in number of clinical trials are expected to fuel the global T-cell acute lymphoblastic leukemia market. (transparencymarketresearch.com)
The global T-cell acute lymphoblastic leukemia market has been segmented based on treatment, end-user, and region. (transparencymarketresearch.com)
Based on end-user, the global T-cell acute lymphoblastic leukemia market has been categorized into hospitals, clinics, and others. (transparencymarketresearch.com)
Moreover, hospitals provide advanced medical treatment to treat T-cell acute lymphoblastic leukemia patients. (transparencymarketresearch.com)
In terms of region, the global T-cell acute lymphoblastic leukemia market has been segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. (transparencymarketresearch.com)
The market in North America is driven by increase in incidence of T-cell acute lymphoblastic leukemia, new product approvals, strong product pipeline, and rise in health care expenditure. (transparencymarketresearch.com)
The T-cell acute lymphoblastic leukemia market in Asia Pacific is anticipated to grow at a rapid pace during the forecast period. (transparencymarketresearch.com)
Japan dominated the T-cell acute lymphoblastic leukemia market in the region. (transparencymarketresearch.com)
The increasing cases of cancer worldwide and the rising prevalence of lymphoblastic leukemia is likely to emerge as the key driver of the global T-cell acute lymphoblastic leukemia market. (transparencymarketresearch.com)
White blood cell acute lymphoblastic leukemia (T-ALL) is a kind of acute lymphoblastic leukemia, with highlights like lymphoma. (transparencymarketresearch.com)
Ascend in pervasiveness of T-ALL and fast innovative progressions help the worldwide T-cell acute lymphoblastic leukemia market. (transparencymarketresearch.com)
Also, expansion in medical services use and ascend in number of clinical preliminaries are required to fuel the worldwide T-cell acute lymphoblastic leukemia market. (transparencymarketresearch.com)
Vibecotamab is under clinical development by Xencor and currently in Phase I for B-Cell Acute Lymphocytic Leukemia (B-Cell Acute Lymphoblastic Leukaemia). (pharmaceutical-technology.com)
According to GlobalData, Phase I drugs for B-Cell Acute Lymphocytic Leukemia (B-Cell Acute Lymphoblastic Leukaemia) have a 90% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. (pharmaceutical-technology.com)
Vibecotamab(XmAb-14045) is under development for the treatment of hematologic malignancies such as relapsed/refractory acute myeloid leukemia, B-cell acute lymphoblastic leukemia, blastic plasmacytoid dendritic cell neoplasm, myelodysplastic syndrome and chronic myeloid leukemia. (pharmaceutical-technology.com)
Antineoplastic agents are used for induction, consolidation, and maintenance therapy and central nervous system (CNS) prophylaxis in patients with acute lymphoblastic leukemia (ALL). (medscape.com)
Corticosteroids may be used during induction, consolidation, and/or maintenance therapy for acute lymphoblastic leukemia (ALL). (medscape.com)
Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A. (lu.se)
Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease that arises in a multistep fashion through acquisition of several genetic aberrations, subsequently giving rise to a malignant, clonal expansion of T-lymphoblasts. (lu.se)

There was the abstract we presented, the ZUMA data, showing that prior blinatumomab, even if patients received blinatumomab as their last line of therapy and were refractory, did not impact the likelihood of response to CAR T-cell immunotherapy using what's now called the Tecartus [brexucabtagene, autoleucel] product from Kite. (onclive.com)

AML may sometimes be called acute myelogenous leukemia, acute myelocytic leukemia, or acute nonlymphocytic leukemia. (cancer.net)
Acute myelogenous leukemia (AML) is a type of cancer that involves the bone marrow. (medicalnewstoday.com)

Mesenchymal stem cells (MSCs) have been studied for their potential benefits in treating acute respiratory distress syndrome (ARDS) and have reported mild effects when trialed within human clinical trials. (lu.se)

A graphical representation of variants found in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stock P1 and P2, as well as the apical washes from SARS-CoV-2-infected monkey and cat airway epithelial cell cultures with either P1 or P2 stock 96 hpi at 33°C or 37°C. SARS-CoV-2/Wuhan-Hu-1 (GenBank accession no. (cdc.gov)
Acute liver failure is a life-threatening clinical syndrome characterized by rapid development of hepatocellular necrosis leading to high mortality and resource costs. (springer.com)
Acute liver failure (ALF) is a life-threatening clinical syndrome characterized by rapid hepatocellular necrosis due to various acute injuries induced by hepatotoxic drugs, immune-mediated attack, or viral infections. (springer.com)
Vaso-occlusive crises: painful episodes of microvascular occlusion that involve joints, bones, and internal organs such as the spleen, lungs (acute chest syndrome), liver, kidneys, and central nervous system. (logicalimages.com)
Acute chest syndrome is a leading cause of mortality in patients with sickle cell and is discussed separately. (logicalimages.com)
Acute chest syndrome is an important complication of sickle cell disease characterised by fever and/or respiratory symptoms and a new pulmonary infiltrate on chest X-Ray. (b-s-h.org.uk)
Following an episode of acute chest syndrome the patient should be offered disease modifying therapy (eg hydroxycarbamide, blood transfusion). (b-s-h.org.uk)
For example, if patients had bone marrow (BM) blasts up to 20% during the pre-conditioning stage, treatment was given at 100 x 10 6 CAR T-cell dose and, if any events of cytokine release syndrome (CRS) were below grade 2 and there were no cases of immune effector cell-associated neurotoxicity syndrome (ICANS), obe-cel was administered again at a 310 x 10 6 CAR T-cell dose. (cancernetwork.com)
Acute simple transfusions should be considered in certain circumstances including acute chest syndrome, acute stroke, aplastic anemia, preoperative transfusion, splenic sequestration plus severe anemia, acute hepatic sequestration, and severe acute intrahepatic cholestasis. (the-hospitalist.org)
Exchange transfusion (erythrocytapheresis) should be considered for seriously ill patients, including those with multisystem organ failure, severe acute chest syndrome, and acute stroke. (the-hospitalist.org)
Acute chest syndrome (ACS) presents as a pneumonia radiographically consistent with a respiratory tract infection caused by cough, shortness of breath, retractions, and/or rales. (the-hospitalist.org)
Severe acute chest syndrome is distinguished by radiographic evidence of multilobe pneumonia, increased work of breathing, pleural effusions, and oxygen saturation below 95% with supplemental oxygen. (the-hospitalist.org)
CAR-T therapy may result in serious side effects including two potentially dangerous syndromes: Cytokine Release Syndrome (CRS) and Immune Cell-Associated Neurotoxicity Syndrome (ICANS). (cdc.gov)
Acute lung injury (ALI)/ acute respiratory distress syndrome (ARDS) is a critical and life -threatening illness that causes severe dyspnea , and respiratory distress and is often caused by a variety of direct or indirect factors that damage the alveolar epithelium and capillary endothelial cells , leading to inflammation factors and macrophage infiltration. (bvsalud.org)
What is acute chest syndrome? (first10em.com)
Acute chest syndrome is a common and potentially deadly complication of sickle cell disease. (first10em.com)
Acute chest syndrome is defined as a new pulmonary infiltrate of at least one lung segment (not atelectasis) with accompanying symptoms of fever, chest pain and/or respiratory signs or symptoms. (first10em.com)
Can acute chest syndrome be prevented? (first10em.com)
Almost 50% of patients develop acute chest syndrome during a hospitalization for another illness, such as an acute pain crisis. (first10em.com)
Hydroxyurea therapy should be considered for patients after a single episode of acute chest syndrome. (first10em.com)
How is acute chest syndrome treated? (first10em.com)
All children with acute chest syndrome should be admitted to hospital. (first10em.com)
They were looking at the accuracy of history, physical, and laboratory findings for identifying acute chest syndrome on chest x ray. (first10em.com)

Acetaminophen (APAP) poisoning is one of the leading causes of acute hepatic failure and liver transplantation is often the only lifesaving alternative. (mdpi.com)
2 It may also be used for hepatic sequestration and acute intrahepatic cholestasis. (the-hospitalist.org)
Acute hepatic sequestration (AHS) occurs with the sequestration of RBCs in the liver and is marked by greater than 2 g/dL decrease in hemoglobin and hepatic enlargement, compared with baseline. (the-hospitalist.org)
Cincinnati Children's is excited to be one of the few sites worldwide that is able to offer acute extracorporeal liver support, or Molecular Adsorbent Recirculating System (MARS) therapy , for those patients that have hepatic encephalopathy or for the treatment of drug overdose and poisoning. (cincinnatichildrens.org)
MARS provides efficient removal of exogenous and endogenous hepatic toxins in patients with acute liver failure. (cincinnatichildrens.org)

DC-mediated NKT cell activation is critical in initiating the immune response following kidney ischemia/reperfusion injury (IRI), which mimics human acute kidney injury (AKI). (jci.org)
Several reports suggested that acute kidney injury (AKI) is a relatively common occurrence in hospitalized COVID-19 patients, but its prevalence is inconsistently reported across different populations. (frontiersin.org)
The Center for Acute Care Nephrology offers comprehensive therapy options when treating acute kidney injury needs. (cincinnatichildrens.org)
Acute renal replacement therapies can be initiated for acute kidney injury, fluid overload and/or sepsis. (cincinnatichildrens.org)
CRRT is reserved for the sickest patients with acute kidney injury as it supports the chance of regaining kidney function and renal function recovery. (cincinnatichildrens.org)
His workup showed a low blood cell count and signs of acute kidney injury. (cdc.gov)

Cytogenetically normal refers to the fact that this form of acute myeloid leukemia is not associated with large chromosomal abnormalities. (medlineplus.gov)

AML is the most common type of acute leukemia in adults, and it happens when the bone marrow begins making myeloblasts, also called blasts. (medicalnewstoday.com)
However, of the forms of acute leukemia that affect adults, AML currently has the shortest length of survival. (medicalnewstoday.com)
Asthma management for children and adults with both sickle cell disease and asthma should be optimized, and a referral to an asthma specialist should be considered. (first10em.com)
Acute myeloid leukemia (AML) remains the most common form of acute leukemia in adults, with a 5-year survival rate of 30.5% among all patients diagnosed between 2012 and 2018 in the United States. (jnccn.org)
Background Adults with acute myeloid leukemia (AML) or other high-grade myeloid neoplasms typically remain hospitalized during the several weeks of profound pancytopenia after intensive induction chemotherapy. (jnccn.org)

Eighty to 85% of pediatric ALL cases originate in B-cells. (medscape.com)
This is a retrospective chart review looking at children with sickle cell disease aged 3 months to 21 years presenting to one of two pediatric emergency departments with a fever. (first10em.com)

These painful crises cause significant suffering and stigmatization for sickle cell patients, who are often unjustly described as drug seekers and accused of faking their pain. (logicalimages.com)
The aim of this survey was to establish the pain management approaches to acute painful crisis (APC) in sickle cell patients at two healthcare facilities and to compare with available guidelines. (uwi.edu)
A multi-centre observational survey of the management of APC in sickle cell patients was conducted. (uwi.edu)
Commonly used for sickle cell patients in acute sickling crisis, or used as preventive maintenance to avoid complications of the disease. (cincinnatichildrens.org)

Additionally, 53.2% of patients were refractory to their last prior line of therapy, and 38.3% had underwent allogeneic stem cell transplant. (cancernetwork.com)

Recently, we and others have shown that allogeneic hematopoietic stem cell transplantation (allo-HSCT) may represent a valid treatment option in leukemic myeloid sarcoma. (haematologica.org)

Chemotherapy resistant leukaemic stem cells (LSC) are thought to be responsible for relapses after therapy in acute myeloid leukaemia (AML). (eur.nl)
Configuration of immunoglobulin and T cell receptor beta and gamma genes in acute myeloid leukaemia: pitfalls in the analysis of 40 cases. (bmj.com)

Doctors may also refer to it as acute myeloid leukemia , acute nonlymphocytic leukemia, acute myelocytic leukemia, or acute granulocytic leukemia. (medicalnewstoday.com)

Acute splenic sequestration (ASS) and chronic hypersplenism are common features of homozygous sickle cell (SS) disease in the first 5 years of life affecting one-third of subjects in the Jamaican Cohort Study. (hindawi.com)
These observations are consistent with acute splenic sequestration having a distinct phenotype which may be helpful in predicting those at risk of this complication and suggest that the mechanism of these differences merit further study. (hindawi.com)
Acute splenic sequestration presents as a decrease in hemoglobin by greater than 2 g/dL, elevated reticulocyte count and circulating nucleated red blood cells, thrombocytopenia, and sudden splenomegaly. (the-hospitalist.org)

For examples, Rhenen et al showed that a high percentage of CD34 + CD38 - stem cells at diagnosis significantly correlated with a high minimal residual disease frequency and subsequently to relapse especially after the third course of chemotherapy in AML patients. (researchsquare.com)
Consolidation chemotherapy can follow induction chemotherapy to treat any remaining leukemia cells that are not visible in the blood or bone marrow. (medicalnewstoday.com)
Research suggests that while treatments such as intensive chemotherapy and allogeneic stem cell transplantation may be curative for younger people, they are less likely to be effective in older individuals. (medicalnewstoday.com)
Cancer chemotherapy is based on an understanding of tumor cell growth and how drugs affect this growth. (medscape.com)
This difference allows normal cells to recover from chemotherapy more quickly than malignant ones and is the rationale behind current cyclic dosage schedules. (medscape.com)
By removing the high level of white blood cells from the blood, the chemotherapy therapy used to treat the leukemia can be more effective. (cincinnatichildrens.org)

K cell activity, which was increased during remission in several patients, was normal in all patients off therapy. (karger.com)
The CMV-induced generation of highly differentiated adaptive-like NK cells has been proposed to affect favorably on the maintenance of remission in patients with acute myeloid leukemia (AML) after allogeneic stem cell transplantation (allo-SCT). (aacrjournals.org)

U. , D. Santhosh, S. Kumar, R. Singh and J. Prakash, "Adult Acute T Cell Leukemia Presenting as Acute Renal Failure, Parotid Swelling and Loss of Vision," International Journal of Clinical Medicine , Vol. 5 No. 1, 2014, pp. 32-35. (scirp.org)
K. P. Harris, J. M. Hattersley, J. Feehally and J. Walls, "Acute Renal Failure Associated with Haematological Malignancies: A Review of 10 Years Experience," European Journal of Haematology, Vol. 47, No. 2, 1991, pp. 119-122. (scirp.org)
H. H. Hsu, Y. L. Chan and C. C. Huang, "Acute Spontaneous Tumor Lysis Presenting with Hyperuricemic Acute Renal Failure: Clinical Features and Therapeutic Approach," Journal of Nephrology, Vol. 17, No. 1, 2004, pp. 50-56. (scirp.org)
Sun J, Teng G, Ma Z, Ju S. In vivo monitoring of magnetically labeled mesenchymal stem cells intravascularly administered in rat acute renal failure. (smw.ch)

mesenchymal stem cells are most commonly used because they are easy to obtain and present no ethical problems. (springer.com)
The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)

We hypothesized that integrin α10β1 selected-MSCs can be used to treat a sepsis-induced ARDS in a porcine model when administering cells after established injury rather than simultaneously. (lu.se)
Advancements in understanding the role of microRnas in regulating macrophage polarization during acute lung injury. (bvsalud.org)

All 30 genes known to illegitimately recombine with TCR genes function primarily to regulate epigenetics through roles such as signal transducers, transcription factors (tumor suppressors or oncogenes), cell cycle regulators, or ribosomal proteins. (wikipedia.org)
MSK investigators have used a lab tool originally developed to study fly nerve cells to study RNA-binding proteins in blood cells from mammals. (mskcc.org)
If you think of cells as factories for making proteins, and DNA as the instructions contained within those factories, RNA is the workforce that actually carries out the manufacturing. (mskcc.org)
Further, small interfering RNA (siRNA) against the target gene was co-transfected with miR-149-5p inhibitor, and then the cell apoptosis and the expression of apoptosis-related proteins were assessed. (medscimonit.com)
Chimeric antigen receptors (CARs) are synthetic proteins expressed on the surface of T cells. (medscape.com)
The proteins produced from these genes have different functions in the cell. (medlineplus.gov)
The proteins produced from the CEBPA and DNMT3A genes regulate gene activity and help to control when cells divide and how they mature. (medlineplus.gov)
Although the proteins produced from two other genes involved in CN-AML, IDH1 and IDH2 , are not normally involved in proliferation, differentiation, or survival of cells, mutations in these genes lead to the production of proteins with a new function. (medlineplus.gov)
ACE-2 and TMPRSS-2, surface cell proteins expressed by various tissues, are targeted by SARS-CoV-2. (frontiersin.org)

The only curative treatment for acute liver failure is liver transplantation, but there are many restrictions on the application of liver transplantation. (springer.com)
O. M. Suriya and A. Aleem, "Frank Hematuria as the Presentation Feature of Acute Leukemia," Saudi Journal of Kidney Diseases and Transplantation, Vol. 21, No. 5, 2010, pp. 940-942. (scirp.org)
OBJECTIVES: I. Determine whether mixed or full donor chimerism can be safely established in older patients with acute myeloid leukemia (AML) treated with nonmyeloablative conditioning comprised of low dose total body irradiation, followed by allogeneic peripheral blood stem cell transplantation, followed by unrelated donor lymphocyte infusion (DLI). (knowcancer.com)

In acute graft-versus-host disease (aGVHD), donor T cells attack the recipient's gastrointestinal tract, liver, and skin. (nih.gov)

The build-up of malignant T-cells in T-ALL are clones with identical T-cell receptor gene arrangements having taken rise from a single cell. (wikipedia.org)
In support of this initial hypothesis, we found that different secondary lymphoid organs (SLOs) imprint distinct homing receptor phenotypes on evolving alloreactive effector T cells in vivo. (nih.gov)
Moreover, the CD34 + CD38 - progenitor cells expressed variable amounts of the target receptor CD33, CD133 and c-kit (CD117) [ 20 ]. (researchsquare.com)
Chimeric antigen receptor (CAR) T-cell therapy is a rapidly growing treatment modality. (medscape.com)
Once infused, the cells continue to expand in number and bind to cancer cells via the engineered receptor, resulting in immunologic cancer cell death. (medscape.com)
The World Trade Center (WTC) Health Program developed a new Medical Coverage Determination (MCD) for Chimeric Antigen Receptor T-cell (CAR-T) Therapy, outlining coverage details and criteria. (cdc.gov)

We examined the CD45 dim CD34 + CD38 - CD133 + cells on bone marrow samples of hematologic malignancies and healthy controls using four-color flow cytometry experiments. (researchsquare.com)

Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
The first from Nirali Shah, MD, MHSc, from the NCI [National Cancer Institute], their consortium of investigators suggested that maybe there is an impact on both CD19 antigen density and the likelihood of response to subsequent CAR T-cell immunotherapy. (onclive.com)
In approved products, a patient's own T lymphocytes are collected by apheresis and transduced with a gene that encodes for a CAR to direct the T cells against cancer cells. (medscape.com)
Cytogenetically normal acute myeloid leukemia (CN-AML) is one form of a cancer of the blood-forming tissue (bone marrow) called acute myeloid leukemia. (medlineplus.gov)
In CAR-T therapy, a T-cell-a specific type of cell-is taken from a patient's blood and changed in the laboratory so it will attack cancer cells. (cdc.gov)
White blood cells are removed from the blood, then T-cells are separated and sent to the laboratory so that the cells can be changed to attack cancer cells. (cdc.gov)
This is the first page of Cancer.Net's Guide to Adult Acute Myeloid Leukemia. (cancer.net)

The most common clinical feature amongst patients is the proliferation of malignant clones, hence suppressing normal hematopoiesis, resulting in deficiency of functioning peripheral blood cells (particularly thrombocytes) deficiency. (wikipedia.org)
T-Cell TCR encoded by TRA, TRD, and TRG at chromosome bands 14q11 and 7q34 become malignant in T-ALL patients. (wikipedia.org)
The causative mutation in sickle cell disease primarily arose on the African continent, so, globally, most patients share an African ancestry. (logicalimages.com)
Originally as a result of the transatlantic slave trade from Africa, nearly all sickle cell disease patients in the United States are Black. (logicalimages.com)
Similarly, for patients whose BM blasts were greater than 20%, then obe-cel was first given at 10 x 10 6 CAR T-cell dose. (cancernetwork.com)
Figure 1 Survival of acute myeloid leukemia patients (without palliative) according to 1% CD34+CD38- cut-off. (wjgnet.com)
The expression of miR-149-5p in leukemia cell lines, as well as the blood and bone marrow (BM) samples from leukemia patients, were monitored by reverse-transcription polymerase chain reaction (RT-PCR). (medscimonit.com)
OUTLINE: Conditioning: Patients undergo low dose total body irradiation followed by infusion of allogeneic peripheral blood stem cells (PBSC) on day 0. (knowcancer.com)
Preoperative transfusion is used to decrease the incidence of postoperative vaso-occlusive crisis, acute stroke, or ACS for patients receiving general anesthesia. (the-hospitalist.org)
CD45RA is expressed on leukaemic cells in the majority of AML patients. (eur.nl)
Interestingly, the CD45 dim CD34 + CD38 - CD133 + cells were highly expressed in bone marrow of patients with AML compared to that of healthy controls (HC). (researchsquare.com)
Additionally, the high levels of the CD45 dim CD34 + CD38 - CD133 + cells in AML patients were an independently significant poor risk factor for overall survival and event free survivals. (researchsquare.com)
In this study, we focused on measuring LSCs easily in the bone marrow cells from AML patients by developing a four-color flow cytometric analysis. (researchsquare.com)
The impact of CMV infection and adaptive-like NK cells on relapse and survival of patients with AML not receiving allo-SCT remains unknown. (aacrjournals.org)
CD4 counts provide a good asessment of innate immunity via T cells in patients infected with HIV. (medscape.com)
200 cells/µL, patients are at a greater risk for life-threatening, AIDS-defining, opportunistic infections. (medscape.com)
It is commonly used for patients who may be experiencing acute rejection of a transplanted organ, some neurological issues and those patients with extremely elevated white cell counts or elevated sickle hemoglobin cells. (cincinnatichildrens.org)
intravenously on days 1-3) because of the presence of the IDH1 mutation, which is present in 7% to 14% of patients with acute myeloid leukemia (AML). (jnccn.org)

Platelets, small anucleate cells that circulate in the blood stream, are essential for normal hemostasis but also play major roles in inflammation, immunity, wound healing, tumor metastasis, and the development and maintenance of lymph vessels ( Leslie, 2010 ). (rupress.org)
develop into several types of blood cells: white blood cells (leukocytes) that protect the body from infection, red blood cells (erythrocytes) that carry oxygen, and platelets (thrombocytes) that are involved in blood clotting . (medlineplus.gov)
The large number of abnormal cells in the bone marrow interferes with the production of functional white blood cells, red blood cells, and platelets. (medlineplus.gov)

In addition, administration of DCs treated ex vivo with an A2AR agonist protected the kidneys of WT mice from IRI by suppressing NKT production of IFN-γ and by regulating DC costimulatory molecules that are important for NKT cell activation. (jci.org)
We conclude that ex vivo A2AR-induced tolerized DCs suppress NKT cell activation in vivo and provide a unique and potent cell-based strategy to attenuate organ IRI. (jci.org)
Acute toxicity of boron nitride nanotube s in-vitro and in-vivo. (cdc.gov)
Since its toxicity is largely unknown, we performed acute in-vitro and in-vivo exposure studies with 13-23 nm diameter x 0.6-1.6 microm length BNNTs. (cdc.gov)

ACS is usually from infection but may be because of fat embolism, intrapulmonary aggregates of sickled cells, atelectasis, or pulmonary edema. (the-hospitalist.org)
Human cytomegalovirus (CMV) infection is reported to promote NK cell differentiation and education. (aacrjournals.org)
We characterized the hierarchy of HIV-1-specific T-cell gamma interferon (IFN-γ) enzyme-linked immunospot (ELISPOT) assay responses during acute subtype C infection in 53 individuals and associated temporal patterns of responses with disease progression in the first 12 months. (columbia.edu)
This is due partly to viral sequence variation but also to the recognition of invariant viral epitopes that leads to waves of persistent T-cell immunity, which appears to associate with slower disease progression in the first year of infection. (columbia.edu)
The bone marrow and blood cells are an important part of the body's immune system, which helps fight infection. (cancer.net)
In the past biennium, working groups have concluded that there is sufficient evidence to classify infection with human immunodeficiency virus (HIV-1), human T-cell lymphotropic virus (HTLV-1), Epstein-Barr virus (EBV) and the Kaposi sarcoma-associated herpesvirus 8 as carcinogenic to humans (IARC 0RQRJUDSKV, Vol. 67 and 70). (who.int)

The disease stems from cytogenic and molecular abnormalities, resulting in disruption of developmental pathways controlling thymocyte development, tumor suppressor development, and alterations in control of cell growth and proliferation. (wikipedia.org)
Most are involved in regulating processes such as the growth and division (proliferation), maturation (differentiation), or survival of cells. (medlineplus.gov)
For example, the protein produced from the FLT3 gene stimulates the proliferation and survival of cells. (medlineplus.gov)
MicroRNAs ( miRNA ) are conserved, endogenous, short non- coding RNAs composed of 18-25 nucleotides that serve as potential markers for many diseases and are involved in various biological processes , including cell proliferation , apoptosis , and differentiation. (bvsalud.org)

Distinct from adult T-cell leukemia where T-cell lymphotropic virus Type I causes malignant maturation of T-cells, T-ALL is a precursor for lymphoid neoplasm. (wikipedia.org)

Which Febrile Children With Sickle Cell Disease Need a Chest X-Ray? (first10em.com)

The gene rearrangements, as a result of the malignant cell, juxtapose both TCR genes and other critical genes that code for transcription factors. (wikipedia.org)
We describe the first report of RNA sequencing of 5' capped (Pol II) RNAs isolated from acutely hepatitis C virus (HCV) infected Huh 7.5 cells that provides a general approach to identifying differentially expressed annotated and unannotated genes that participate in viral-host interactions. (mdpi.com)

Numerous treatment strategies for acute liver failure simply prevent complications and decelerate disease progression. (springer.com)
What are indications, complications of acute blood transfusions in sickle cell anemia? (the-hospitalist.org)

the bone marrow makes large numbers of abnormal, immature white blood cells called myeloid blasts. (medlineplus.gov)

The genetic mutation results in an abnormal β-globin chain of hemoglobin A, and is known as hemoglobin S. Homozygote mutations for hemoglobin S manifest sickle cell disease, a chronic disabling disease. (logicalimages.com)
In general, cancers result from mutations in cells. (medicalnewstoday.com)
These mutations can stop bone marrow cells from maturing normally and may cause cells to grow out of control. (medicalnewstoday.com)

MNKPL is classified as mixed phenotype acute leukemia, and not otherwise speciﬁed rare types (MPAL NOS rare types) in WHO classification. (confex.com)

Selective killing of leukemic cells it thought to be due to depletion of plasma asparagine, the amino acid required for protein synthesis. (medscape.com)

It is an extended bi-specific monoclonal antibody which contains both tumor antigen binding domain CD123 and cytotoxic T-cell binding domain (CD3 binding domain). (pharmaceutical-technology.com)
Xencor 's Vudalimab is a bispecific antibody that simultaneously targets immune checkpoint receptors PD-1 and CTLA-4 and is designed to promote tumor-selective T-cell activation. (pharmaceutical-technology.com)
Its Plamotamab is a tumor-targeted antibody that contains both a CD20 binding domain and a cytotoxic T-cell binding domain (CD3). (pharmaceutical-technology.com)
Myeloid sarcoma (MS), also known as granulocytic sarcoma or chloroma, is a rare extramedullary tumor composed of immature myeloid cells at different stages of differentiation which can involve any site of the body. (haematologica.org)
Occasionally, AML cells can form a solid tumor called a myeloid sarcoma or chloroma that can develop anywhere in the body. (cancer.net)

Obe-cel is a CD19-directed CAR T-cell therapy, designed to mitigate safety concerns and improve persistence, she explained. (cancernetwork.com)
We've seen in now multiple studies, the more heavily pretreated the patient, the less likely even CAR T-cell therapy is going to work, and that may be a reflection of T-cell fitness or other factors that we haven't assessed. (onclive.com)
We have to deal with the reality that CAR T-cell therapy is not yet approved in the first-relapse setting. (onclive.com)
Several types of adoptive cell transfer are under investigation, but CAR T-cell therapy is the first to enter clinical practice. (medscape.com)
The first report of CAR T-cell therapy was in 2010, in a patient with advanced follicular lymphoma. (medscape.com)
CAR-T cell therapy is given to the patient by infusion as a one-time treatment in a hospital setting or CAR-T outpatient center to allow for monitoring of potential side effects. (cdc.gov)
This therapy removes white blood cells from a patient with newly diagnosed or relapsing leukemia. (cincinnatichildrens.org)
This therapy supports the patient with acute liver failure, providing a chance to recover native liver function. (cincinnatichildrens.org)

We've seen durable remissions with CAR T-cell immunotherapy. (onclive.com)

See sickle cell disease for discussion of sickle cell leg ulcers and other more chronic manifestations. (logicalimages.com)
Unlike chronic leukemia, acute leukemia develops quickly and generally needs immediate treatment. (cancer.net)
There is conflicting evidence about the benefit of chronic red blood cell (RBC) transfusions for the prevention of ACS, and they and are not routinely recommended. (first10em.com)

Acute myeloid leukemia (AML) starts in the bone marrow, the spongy tissue inside your bones that makes blood cells. (cancer.net)
When the cells in the bone marrow are damaged, blood cells do not develop as they should. (cancer.net)
As they grow and divide, the cancerous myeloblasts fill up the bone marrow, preventing healthy cells from being made. (cancer.net)

Acute myeloid leukemia (AML) is generally regarded as a stem cell disease, and it originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity [ 1 , 2 ]. (researchsquare.com)
Lack of asparagine synthetase activity results in cytotoxicity specific for leukemic cells that depend on an exogenous source of the amino acid asparagine. (medscape.com)

Flow cytometry can discriminate CD34+CD38- LSC and normal haematopoietic stem cells (HSC) by using aberrant expression of markers and scatter properties. (eur.nl)
Therefore, our results suggest that CD45 dim CD34 + CD38 - CD133 + cells in AML might have the potential of leukemia stem cells. (researchsquare.com)

Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice. (iasp-pain.org)
Together, our data suggest that Piezo channels can mediate touch and indirectly suppress acute pain. (iasp-pain.org)

Moreover, transfer of alloreactive effector T cells into conditioned secondary recipients targeted the intestines and liver, irrespective of their initial priming site. (nih.gov)
The intracellular domains ensure intracellular signaling necessary to activate the effector functions of the CAR T cell. (medscape.com)
Control of effector immune responses by Treg cells depend on their capacity to accumulate at inflammatory site and accordingly accommodate to inflammatory environment. (ozgene.com)
Moreover, a combined action of Foxp3 and SMAR1 restricts effector cytokine production and enhance the production of IL-10 by colonic Treg cells that controls acute colitis. (ozgene.com)

Anatomy6

Diseases10

Chemicals and Drugs14

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes6

Information Science2

Lymphoblastic34

Abstract1

Myelogenous leukemia2

Treating acute respirat1

Syndrome23

Hepatic5

Kidney injury6

Form of acute myeloid1

Adults5

Pediatric2

Sickle cell patients4

Refractory1

Allogeneic hematopoietic stem c1

Myeloid leukaemia2

Myelocytic leukemia1

Splenic sequestration3

Chemotherapy6

Remission2

Renal Failure4

Mesenchymal stem2

Injury2

Proteins9

Transplantation3

Donor1

Receptor6

Malignancies1

Cancer7

Patients18

Platelets3

Vivo4

Infection6

Proliferation4

Maturation1

Chest1

Genes2

Complications2

Immature white blood1

Mutations3

Phenotype1

Depletion1

Tumor5

Therapy8

Immunotherapy1

Chronic3

Bone3

Leukemic2

CD342

Suppress2

Effector4