OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
CeftriaxoneCefotaximeAnti-Bacterial AgentsCephalosporinsMicrobial Sensitivity TestsCephalosporin ResistanceMeningitis, PneumococcalCefiximeGonorrheaNeisseria gonorrhoeaeDrug Resistance, MicrobialStreptococcus pneumoniaePenicillin ResistanceDrug Resistance, Bacterialbeta-LactamsPenicillinsExcitatory Amino Acid Transporter 2MeningitisLactamsCefuroximeCiprofloxacinbeta-LactamasesAmpicillinMeningitis, HaemophilusDrug Resistance, Multiple, BacterialAnti-Infective AgentsCeftazidimeSerum Bactericidal TestDrug ResistanceCefotiamBacterial InfectionsDrug Therapy, CombinationSpectinomycinMeningitis, BacterialGram-Negative BacteriaNetilmicinAzithromycinInjections, IntramuscularFluoroquinolonesSulbactamCeftizoximeInjections, IntravenousSalmonella Infectionsbeta-Lactam ResistancePenicillin GVancomycinEndocarditis, BacterialTyphoid FeverPneumococcal InfectionsHalf-LifeGram-Negative Bacterial Infections
Third-generation ceAntibioticsAzithromycinNeisseriaCephalosporinCiprofloxacinSpectinomycinBacteriaGonorrhoeaeInfectionAmpicillinCephalosporinsChloramphenicolInfectionsResistance to ceftriaxoneGrams of ceftriaxoneCefixime and ceftriaxoneGonorrheaSingle doseEmergenceBacterialDoseColiGonococcalPathogensCefoxitinMICsClinicalTetracyclineMeropenemEnterobacteriaceaeIsolates were resistantCefotaximeTyphiSusceptibleMultidrugPenicillin-resistant strainsSalmonellaInjectionTreatmentRocephinGentamicinCarbapenem-resistantFluoroquinolone-resistantOrganismsShigellaExtensivelyTyphoid
Third-generation ce6
  • A new public health concern is northern France (online Appendix Table, available from the emergence of third-generation cephalosporin-resistant www.cdc.gov/EID/content/14/6/954-appT.htm). (cdc.gov)
  • It has been hypothesized that use of ceftio- tion cephalosporin-resistant Newport isolates (additional fur, a third-generation cephalosporin licensed in the United information available from [email protected]). (cdc.gov)
  • Assessment of Third Generation Cephalosporin (Ceftazidime and Ceftriaxone) Resistant Escherichia Coli Strains Isolated from Zahedan Hospitals by Tracing the TEM Gene', Journal of Applied Biotechnology Reports , 4(1), pp. 547-552. (biotechrep.ir)
  • Ceftriaxone (a third generation cephalosporin) use is a risk factor for colonization and infection by VRE, and restriction of cephalosporin usage has been associated with decreased VRE infection and transmission in hospitals. (wikipedia.org)
  • For complicated typhoid the choice of drug is parenteral third generation cephalosporin e.g. ceftriaxone (2). (pediatriconcall.com)
  • A news item by project partner Mérieux Foundation explains: "A new lineage of S. Typhi that is highly resistant to first-line antibiotics in the fluoroquinolone family has been described for the first time, along with a new strain that is highly resistant to ceftriaxone, a third-generation cephalosporin that is the most commonly prescribed treatment for typhoid fever. (europa.eu)
Antibiotics19
  • Ceftriaxone injection is in a class of medications called cephalosporin antibiotics. (medlineplus.gov)
  • Antibiotics such as ceftriaxone injection will not work for colds, flu, or other viral infections.Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. (medlineplus.gov)
  • If you stop using ceftriaxone injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
  • penicillin antibiotics, or any other medications.Also tell your doctor if you are allergic to any of the ingredients in ceftriaxone injection. (medlineplus.gov)
  • Ceftriaxone and ceftazidime are most commonly-used antibiotics to treat infections caused by Enterobacteriaceae. (biotechrep.ir)
  • Following the initial remarkable success of antibiotics, the emergence and spread of human pathogenic bacteria resistant to antibiotics has become a major phenomenon in the past fifty years. (europa.eu)
  • The emergence and spread of human pathogenic bacteria resistant to antibiotics has become a major problem in the past fifty years. (europa.eu)
  • An alternative is needed because Neisseria gonorrhoeae -which is known for its ability to develop resistance quickly and has cycled through several antibiotics-is becoming increasingly resistant to ceftriaxone. (umn.edu)
  • The isolation of bacterial pathogens resistant to the commonly prescribed antibiotics from pregnant women symptomatic and asymptomatic for UTI calls for early screening of all pregnant women for UTI during antenatal care service delivery. (who.int)
  • However, fluoroquinolones are not approved by Drug Controller General of India to be used under 18 years of age unless the child is resistant to all other recommended antibiotics and is suffering from life threatening infection. (pediatriconcall.com)
  • Inappropriate antibiotic use is a huge problem in Ethiopia, and many bacteria were resistant to commonly used antibiotics and similarly, multidrug-resistant bacterial strains are numerous. (hindawi.com)
  • There are at least 13 antibiotics on the CDC list of drugs the outbreak strains are resistant to, including ampicillin, ciprofloxacin, streptomycin and tetracycline. (foodsafetynews.com)
  • We looked at two currently recommended antibiotics, ceftriaxone and azithromycin, an antibiotic that's similar to ceftriaxone, called cefixime, and an antibiotic that was previously recommended for gonorrhea, called ciprofloxacin. (cdc.gov)
  • The emergence of resistant pathogens calls for the development of novel antibiotics. (scienceboard.net)
  • Susceptibility of N. gonorrhoeae to five antibiotics (ciprofloxacin, ceftriaxone, spectinomycin, penicillin G and tetracycline) was tested systematically. (medicaljournals.se)
  • The rate of quinolone-resistant N. gonorrhoeae was 37.4% (43/115), without significant association with gender, age, sexual behaviour, past history of sexually transmitted diseases and susceptibility to other antibiotics. (medicaljournals.se)
  • The antibiotics currently routinely surveyed are penicillin, ceftriaxone, ciprofloxacin and spectinomycin, all of which are administered as single dose regimens and currently used in Australia to treat gonorrhoea. (health.gov.au)
  • Because some strains of gonorrhea have become antibiotic-resistant, your doctor may prescribe several types of antibiotics. (healthline.com)
  • To further complicate management, bacterial pathogens are becoming increasingly resistant to currently available antibiotics. (medscape.com)
Azithromycin15
  • CDC now recommends dual therapy for gonorrhea with a cephalosporin (ceftriaxone 250 mg) plus either azithromycin or doxycycline ( 4 ). (cdc.gov)
  • Both the US Centers for Disease Control and Prevention and the World Health Organization recommend the combination therapy of intramuscular ceftriaxone and oral azithromycin. (umn.edu)
  • Azithromycin, which has a different mechanism of action than ceftriaxone, was added to the regimen to improve treatment efficacy and to slow the emergence of ceftriaxone resistance. (umn.edu)
  • Participants were randomly assigned 1:1 to receive a single intramuscular dose of either 240-milligrams (mg) gentamicin or 500-mg ceftriaxone, with both groups also receiving a single oral dose of 1 gram (g) of azithromycin. (umn.edu)
  • However, gentamicin combined with 1 g azithromycin achieved a cure rate of 94% for genital gonorrhoea, and its use might be appropriate in patients who are allergic, intolerant, or harbour a ceftriaxone-resistant infection. (umn.edu)
  • of the other five patients, two had azithromycin-resistant isolates and three had isolates with intermediate azithromycin susceptibility. (umn.edu)
  • A 1 g dose of azithromycin as a component of dual therapy for gonorrhoea had limited efficacy in treating gentamicin-resistant infections and this suggests that its widespread use to prevent development of resistance requires review," they write. (umn.edu)
  • This finding from the trial was among the reasons cited by the British Association for Sexual Health and HIV in its decision to drop the recommendation for dual therapy with azithromycin in patients with uncomplicated gonorrhea in its 2019 guidelines, which now recommend a 1-g intramuscular shot of ceftriaxone as the first-line treatment. (umn.edu)
  • Recommended Regimens Azithromycin 1 g orally in a single dose or Ceftriaxone 250 mg intramuscularly (IM) in a single dose or Erythromycin base 500 mg orally 4 times a day for 7 days. (cdc.gov)
  • Azithromycin and ceftriaxone offer the advantage of single-dose therapy. (cdc.gov)
  • Antimicrobial resistance to ceftriaxone and azithromycin has not been reported. (cdc.gov)
  • Currently, there is only a single treatment regimen left that is recommended by CDC for gonorrhea treatment, a combination of two drugs--ceftriaxone and azithromycin. (cdc.gov)
  • The main treatment for uncomplicated gonorrhea is dual therapy with single-dose intramuscular ceftriaxone plus single-dose and purchase amoxicillin 250mg tablets oral azithromycin. (sprintcarworld.com.au)
  • Currently ceftriaxone, an injectable agent, plus azithromycin is the recommended therapy. (sprintcarworld.com.au)
  • The trial, designed to assess the safety and efficacy of oral zoliflodacin versus the current standard of care combination of intramuscular ceftriaxone plus oral azithromycin, is actively enrolling patients with uncomplicated gonorrhea, including infections potentially caused by multidrug-resistant strains of N. gonorrhoeae . (biospace.com)
Neisseria6
Cephalosporin2
  • Ceftriaxone for Injection, USP is a sterile, semisynthetic, broad-spectrum cephalosporin antibiotic for intravenous or intramuscular administration. (nih.gov)
  • Ceftriaxone is a cephalosporin (SEF a low spor in) antibiotic. (onteenstoday.com)
Ciprofloxacin4
  • A test designed by UCLA researchers can pinpoint which people with gonorrhea will respond successfully to the inexpensive oral antibiotic ciprofloxacin, which had previously been sidelined over concerns the bacterium that causes the infection was becoming resistant to it. (uclahealth.org)
  • Scientists have been trying to determine how to better identify cases for targeted use of ciprofloxacin therapy, reducing the need to use the injectable antibiotic ceftriaxone and decreasing the risk of resistance to that drug. (uclahealth.org)
  • The DNA test the researchers developed detects a particular genetic mutation in the gonorrhea bacterium that make it resistant to ciprofloxacin. (uclahealth.org)
  • This may be used if a person is unable to take ciprofloxacin or the bacteria are resistant to ciprofloxacin. (roadlesstraveledstore.com)
Spectinomycin5
Bacteria11
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of ceftriaxone for injection and other antibacterial drugs, ceftriaxone for injection should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
  • The work package focusing on molecular studies generated new evidence about the changes effected by antibiotic therapy on commensal organisms or opportunistic pathogens in the oropharyngeal, nasal and gastro-intestinal flora and study AMR mechanisms and the dissemination of successful clones of fluoroquinolone-resistant, carbapenem-resistant or extended-spectrum beta-lactamase harboring Gram-negative bacteria, MRSA and fluoroquinolone-resistant viridans streptococci. (europa.eu)
  • Also, SATURN had as mission to improve methodological standards and conduct research to better understand the impact of antibiotic use on acquisition, selection and transmission of antibiotic-resistant bacteria (ARB) in different environments, by combining state-of-the-art analyses of molecular, ecologic and individual patient-level data. (europa.eu)
  • Resistant bacteria have emerged in these developing countries. (jabfm.org)
  • The organosulfur compounds of garlic exhibit a range of antibacterial properties such as bactericidal, antibiofilm, antitoxin, and anti-quorum sensing activity against a wide range of bacteria including multi-drug resistant (MDR) strains. (frontiersin.org)
  • The antibacterial activity against various pathogenic and drug-resistant bacteria was tested using crude garlic extracts, garlic powder (GP), garlic extracts using various solvents, GO, and phytochemicals isolated from garlic. (frontiersin.org)
  • Scientists have discovered two new highly drug-resistant forms of bacteria that cause life-threatening typhoid fever. (europa.eu)
  • Scientists supported by the EU-funded COMPARE project have discovered two new extensively drug-resistant (XDR) bacteria causing typhoid fever. (europa.eu)
  • They're also more active against bacteria that may be resistant to previous generations of cephalosporins. (mexico-insights.com)
  • It is important to monitor the emergence of antimicrobial-resistant bacteria in the swine industry because in 2022 the US was the third largest producer and consumer of swine meat and products, after the European Union and China," said Hamid Reza Sodagari, a postdoctoral research associate in the Varga lab. (phys.org)
  • Therefore, parenteral FOF is increasingly prescribed adjunctive therapy to treat extra-urinary tract infections caused by multidrug-resistant, Gram-negative bacteria. (bvsalud.org)
Gonorrhoeae6
  • criteria for cefixime and ceftriaxone resistance in N. gonorrhoeae have not been defined ( 6 ). (cdc.gov)
  • Increasing levels of DoxyPEP uptake and higher starting prevalence of doxycycline resistance resulted in faster loss of its efficacy and had little change on extending the clinical lifespan of ceftriaxone for treatment of N. gonorrhoeae infections. (nih.gov)
  • Resistance to ceftriaxone, often the last antibiotic option against N. gonorrhoeae , has emerged globally. (scienceboard.net)
  • This structural difference enabled researchers to identify bacterial HCO-specific inhibitors including an antibiotic compound, Q275, that are effective against ceftriaxone-resistant N. gonorrhoeae . (scienceboard.net)
  • and (ii) the factors associated with quinolone-resistant N. gonorrhoeae. (medicaljournals.se)
  • The rate of quinolone-resistant N. gonorrhoeae in Paris has been increasing since 2004. (medicaljournals.se)
Infection11
  • most (41, 89.1%) were resistant to streptomycin, substantial sources of Newport MDR-AmpC infection in sulfonamides, chloramphenicol, and tetracycline. (cdc.gov)
  • ABSTRACT We carried out a prospective, randomized, controlled clinical trial to evaluate the clinical efficacy of ceftriaxone and ampicillin/cloxacillin prophylaxis in decreasing the frequency of post-caesarean section infection-related morbidity. (who.int)
  • After 2 weeks of treatment, the infection was cleared in 299 (98%) of the 306 patients in the ceftriaxone arm, compared with 267 (91%) of 292 patients in the gentamicin group, for an adjusted risk difference of -−6.4 percentage points (95% confidence interval [CI], −10.4 to −2.4), indicating inferiority. (umn.edu)
  • 1) Information on extensively drug-resistant (XDR) Salmonel a Typhi (Typhi) infections among U.S. residents without international travel, and 2) Treatment recommendations for XDR Typhi infection. (cdc.gov)
  • Before the outbreak in Pakistan, no case of ceftriaxone-resistant Typhi infection had been identified in the United States [2]. (cdc.gov)
  • For example, a report was just published in EID describing a ceftriaxone-resistant infection in Canada. (cdc.gov)
  • The magnitude by which DoxyPEP initially reduced the prevalence of infection was constrained by the extent of pre-existing doxycycline resistant strains in the population. (nih.gov)
  • Model findings suggest DoxyPEP can be an effective but short-term solution for reducing the burden of gonorrhea infection, as its selection for doxycycline-resistant strains results in loss of its prophylaxis benefit. (nih.gov)
  • Ceftriaxone is also used to prevent infection in people having certain types of surgery. (onteenstoday.com)
  • Given the increased common emergence of multidrug resistant isolates, uninterrupted surveillance will be necessary to understand the actual epidemic burden and control this infection. (researchsquare.com)
  • People infected with a ceftriaxone resistant strain means the drug will not easily treat the infection. (mylondon.news)
Ampicillin6
  • Two hundred patients randomly received either ceftriaxone (single dose) or ampicillin/cloxacillin (3 doses) intravenously at induction of anaesthesia. (who.int)
  • One dose of ceftriaxone was as effective as ampicillin/ cloxacillin in preventing post-caesarean section complications and is easier to administer. (who.int)
  • Patients were randomized to receive ei- the efficacy of ceftriaxone with ampicillin/ ther ceftriaxone as single dose of 1 g or 1 g cloxacillin in preventing post-operative ampicillin/cloxacillin every 8 hours. (who.int)
  • Gram negative isolates showed high resistance rate of 73.1% to ampicillin and 65.4% to amoxicillin-clavulanic acid while Gram-positive isolates showed high resistant rate of 94.1% to penicillin. (who.int)
  • In 1996, in Bangladesh, over 95% of Shigella dysenteriae isolates were resistant to ampicillin, co-trimoxazole, and nalidixic acid, and up to 40% were resistant to mecillinam. (jabfm.org)
  • A high proportion of strains classified as PPNG or else resistant by chromosomal mechanisms fail to respond to treatment with penicillins (penicillin, amoxycillin, ampicillin) and early generation cephalosporins. (health.gov.au)
Cephalosporins4
  • During that period, the percentage of isolates with elevated minimum inhibitory concentrations (MICs) to cephalosporins (≥0.25 µ g/mL for cefixime and ≥0.125 µ g/mL for ceftriaxone) increased from 0.2% in 2000 to 1.4% in 2010 for cefixime and from 0.1% in 2000 to 0.3% in 2010 for ceftriaxone. (cdc.gov)
  • MICs to cephalosporins (cefixime and ceftriaxone) among gonococcal isolates collected during 2000--2010 were analyzed. (cdc.gov)
  • Because few isolates exhibited decreased susceptibility and increases in MICs can precede the emergence of resistance, the percentage of isolates with elevated MICs (≥0.25 µ g/mL for cefixime and ≥0.125 µ g/mL for ceftriaxone) was assessed to determine if MICs to cephalosporins were increasing with time. (cdc.gov)
  • Parenteral third generation cephalosporins include ceftriaxone 50-75mg/kg/day in one or two doses, cefotaxime 40-80 mg/kg/day in two or three doses and cefoperazone 50-100 mg/kg/per day in two doses. (pediatriconcall.com)
Chloramphenicol1
Infections21
  • Ceftriaxone injection is also sometimes given before certain types of surgery to prevent infections that may develop after the operation. (medlineplus.gov)
  • In the United States, vancomycin-resistant E. faecium was associated with 4% of healthcare-associated infections reported to the Centers for Disease Control and Prevention National Healthcare Safety Network from January 2006 to October 2007. (wikipedia.org)
  • The Gentamicin in the Treatment of Gonorrhea (G-ToG) trial was conducted as part of an effort to find an acceptable alternative to ceftriaxone, which is the current recommended treatment for gonorrhea infections. (umn.edu)
  • In 2016, a large outbreak of extensively drug-resistant (XDR) Typhi infections began in Sindh province, Pakistan [1]. (cdc.gov)
  • An unrelated cluster of ceftriaxone-resistant Typhi infections linked to Iraq has been reported in the United States and the United Kingdom [2]. (cdc.gov)
  • Whole genome sequencing of Salmonella isolates found in 43 of the patients and 68 food and environmental samples predicted the bacterial infections are resistant to multiple antibiotic traditionally used. (foodsafetynews.com)
  • Gonorrhea is one of the most common drug-resistant infections worldwide and is becoming harder to treat. (uclahealth.org)
  • And among men, infections among men who have sex with men tend to be more resistant than infections among men who report sex only with women. (cdc.gov)
  • Ceftriaxone is used to treat many kinds of bacterial infections, including severe or life-threatening forms such as E. coli, pneumonia, or meningitis. (onteenstoday.com)
  • Ceftriaxone is also used to treat pelvic inflammatory disease, bacterial septicemia, bone and joint infections, and meningitis. (onteenstoday.com)
  • 8 , 9 Furthermore, the accelerating accumulation and transmission of antimicrobial resistance genes (ARGs) among multidrug resistant (MDR) pathogens pose major difficulties in treating infections. (researchsquare.com)
  • According to CDC treatment guidelines, gonorrhea infections can be treated with a 250-milligram (mg) dose of the antibiotic ceftriaxone (given as an injection) in addition to an oral antibiotic. (healthline.com)
  • Ceftriaxone is used to treat a wide variety of bacterial infections. (mexico-insights.com)
  • Through the dedication of our employees and partners, we have maintained momentum in our Phase 3 registrational trials addressing multidrug-resistant Acinetobacter infections and uncomplicated gonorrhea," commented Manos Perros, President and Chief Executive Officer of Entasis Therapeutics. (biospace.com)
  • We are especially encouraged by the progress achieved in ATTACK, our Phase 3 trial for multidrug-resistant Acinetobacter infections where we now have a clear line of sight to enrolling 120 evaluable patients with carbapenem-resistant infections. (biospace.com)
  • The Company, along with our partner Zai Lab (Nasdaq: ZLAB), has enrolled 108 patients with confirmed carbapenem-resistant Acinetobacter infections in the ATTACK trial. (biospace.com)
  • ATTACK is our single Phase 3 registrational trial that will evaluate SUL-DUR in patients with confirmed carbapenem-resistant Acinetobacter pneumonia and/or bloodstream infections. (biospace.com)
  • The spread of drug-resistant microbes has become a global health concern that threatens our ability to treat infections. (phys.org)
  • Therefore, since it is a global public health problem involving several sectors, it also requires a global solution in the context of the One Health approach to achieve adequate control through the prevention, reduction, and mitigation of drug-resistant infections. (who.int)
  • ABSTRACT Multi-drug resistant (MDR) strains of Acinetobacter baumannii are responsible for an increasing number of opportunistic infections in hospitals. (who.int)
  • The increasing rates of multidrug-resistant (MDR) infections with few novel treatment options available has spurred the recent interest in fosfomycin. (bvsalud.org)
Resistance to ceftriaxone1
  • In particular, the resistance to ceftriaxone, an important antimicrobial drug in both human and veterinary medicine, increased from 0.8% in 2013 to 7.7% in 2019. (phys.org)
Grams of ceftriaxone2
Cefixime and ceftriaxone1
Gonorrhea4
  • The results of a randomized clinical trial conducted in the United Kingdom indicate that gentamicin is not a suitable alternative for ceftriaxone as part of first-line treatment for gonorrhea. (umn.edu)
  • Due to the spread of multidrug-resistant gonorrhea, public health authorities have declared it one of the top five urgent threats to public health . (uclahealth.org)
  • Isolates resistant buy online clarithromycin australia to both drugs have been where to get amoxil brisbane australia reported, raising the specter of untreatable gonorrhea in the future. (sprintcarworld.com.au)
  • But a new drug that specifically targets antibiotic-resistant buy amoxicillin for gonorrhea is giving researchers hope. (sprintcarworld.com.au)
Single dose2
  • Multiple IV or IM doses ranging from 0.5 to 2 g at 12- to 24-hour intervals resulted in 15% to 36% accumulation of ceftriaxone above single dose values. (nih.gov)
  • The results of the present surveillance initiated in 2009 were also used to replace penicillin G with ceftriaxone (1 g single dose intramuscularly) as the first-line drug for empiric treatment of gonorrhoea in the national treatment guidelines in Belarus in late 2009. (biomedcentral.com)
Emergence1
  • Quoted in the same piece, Prof. Hubert Endtz, Director of Applied Research at the Mérieux Foundation, says: "The emergence of these highly resistant strains in Pakistan and now Bangladesh could herald the beginning of a global pandemic of XDR strains. (europa.eu)
Bacterial4
  • The penicillinase-resistant, or second-generation, penicillins are semisynthetic modifications of natural penicillins that are resistant to bacterial enzyme beta-lactamase, which accounts for typical penicillin resistance. (medscape.com)
  • Vancomycin-resistant Enterococcus, or vancomycin-resistant enterococci (VRE), are bacterial strains of the genus Enterococcus that are resistant to the antibiotic vancomycin. (wikipedia.org)
  • Ceftriaxone works by inhibiting the mucopeptide synthesis in the bacterial cell wall. (onteenstoday.com)
  • The beta-lactam moiety of ceftriaxone binds to carboxypeptidases, endopeptidases, and transpeptidases in the bacterial cytoplasmic membrane. (onteenstoday.com)
Dose7
  • Average plasma concentrations of ceftriaxone following a single 30-minute intravenous (IV) infusion of a 0.5, 1 or 2 g dose and intramuscular (IM) administration of a single 0.5 (250 mg/mL or 350 mg/mL concentrations) or 1 g dose in healthy subjects are presented in Table 1. (nih.gov)
  • Ceftriaxone was completely absorbed following IM administration with mean maximum plasma concentrations occurring between 2 and 3 hours post-dose. (nih.gov)
  • Thirty-three percent to 67% of a ceftriaxone dose was excreted in the urine as unchanged drug and the remainder was secreted in the bile and ultimately found in the feces as microbiologically inactive compounds. (nih.gov)
  • After a 1 g IV dose, average concentrations of ceftriaxone, determined from 1 to 3 hours after dosing, were 581 mcg/mL in the gallbladder bile, 788 mcg/mL in the common duct bile, 898 mcg/mL in the cystic duct bile, 78.2 mcg/g in the gallbladder wall and 62.1 mcg/mL in the concurrent plasma. (nih.gov)
  • Deux cent patientes ont reçu de manière aléatoire soit de la ceftriaxone (dose unique) soit de l'ampicilline-cloxacilline (3 doses) par voie intraveineuse à l'induction de l'anesthésie. (who.int)
  • Une dose de ceftriaxone était aussi efficace que l'ampicilline- cloxacilline dans la prévention des complications de la césarienne et elle est plus facile à administrer. (who.int)
  • If you will be using more than one dose of ceftriaxone injection, use the medication until you finish the prescription, even if you feel better. (medlineplus.gov)
Coli6
  • There are few data regarding non-invasive ceftriaxone-resistant E. coli (CR-EC) isolates in the Australian community. (monash.edu)
  • We aimed to describe the prevalence, phenotype, geographic variation, and sociodemographic predictors of ceftriaxone-resistance among E. coli isolates recovered from urine specimens. (monash.edu)
  • Geographic distribution of ceftriaxone resistance among urinary Escherichia coli isolates in Victoria ( a ) and the Greater Melbourne area (b). (biomedcentral.com)
  • Scale represents percentage of E. coli isolates that are resistant to ceftriaxone. (biomedcentral.com)
  • The results of the present study indicate a high rate of antibiotic resistance among E. coli isolates to ceftriaxone and ceftazidime. (biotechrep.ir)
  • Using different statistical methods, the researchers found that since 2013, the number of antimicrobials to which E. coli is resistant has either remained steady or increased over the years. (phys.org)
Gonococcal3
  • Comparison of ceftriaxone with cefoxitin in the treatment of penicillin-resistant gonococcal urethritis. (bmj.com)
  • One hundred and twenty eight men with culture-confirmed gonococcal urethritis were treated with either 250 mg of ceftriaxone intramuscularly or 2 g of cefoxitin intramuscularly with oral probenecid 1 g. (bmj.com)
  • Ceftriaxone was completely effective in treating both penicillin-sensitive and penicillin-resistant gonococcal urethritis. (bmj.com)
Pathogens2
  • Background: Ceftriaxone-resistant Enterobacteriaceae are priority pathogens of critical importance. (monash.edu)
  • Antimicrobial resistance (AMR) is a global health problem which could make drug-resistant pathogens untreatable. (scienceboard.net)
Cefoxitin1
  • Four of the 9 (44.4%) CoNS isolates were cefoxitin resistant and all the 4 (100%) carried mec A gene. (who.int)
MICs1
  • The percentage of isolates with ceftriaxone MICs ≥0.125 µ g/mL increased from 0.1% to 0.3% during 2000--2010 (p = 0.047). (cdc.gov)
Clinical2
  • High-level vancomycin-resistant E. faecalis and E. faecium are clinical isolates first documented in Europe in 1986 and the United States in 1987. (wikipedia.org)
  • Outbreaks have hospital in which the ICUs comprise Antibiotic susceptibility testing was been increasingly reported and most an internal medicine unit (10 beds), a determined using modified Kirby- of those outbreaks are caused by multi- coronary care unit (7 beds), a hepatol- Bauer method following the Clinical drug resistant (MDR) strains of this ogy unit (7 beds), a burns unit (10 beds) Laboratory Standards Institute guide- organism. (who.int)
Tetracycline1
  • High-level tetracycline-resistant strains (36) were detected for the first time in 2004. (bvsalud.org)
Meropenem2
Enterobacteriaceae1
  • Community-acquired antimicrobial resistant Enterobacteriaceae (CA-ARE) are an increasingly important issue around the world. (mdpi.com)
Isolates were resistant1
  • According to the results of antimicrobial susceptibilities, 76.32% (29/38) of S. dysenteriae isolates were resistant to fluoroquinolone and showed multidrug resistance. (researchsquare.com)
Cefotaxime3
Typhi2
  • The nalidixic acid resistant S typhi (NARST) is a marker of reduced susceptibility to fluoroquinolones. (pediatriconcall.com)
  • 6 In Quetta, Pakistan, 69% of Salmonella typhi isolated from blood were multidrug resistant. (jabfm.org)
Susceptible2
  • Six different types of vancomycin resistance are shown by enterococcus: Van-A, Van-B, Van-C, Van-D, Van-E and Van-G. The significance is that Van-A VRE is resistant to both vancomycin and teicoplanin, Van-B VRE is resistant to vancomycin but susceptible to teicoplanin, and Van-C is only partly resistant to vancomycin. (wikipedia.org)
  • [ 1 ] Local antibiograms should be consulted in addition to the following guidelines below for methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S aureus (MRSA), streptococcal species, Haemophilus influenzae , and anaerobes. (medscape.com)
Multidrug8
  • CDC monitors illness from a persisting, multidrug-resistant strain of Salmonella Newport linked to travel to Mexico, beef products obtained in the United States, and cheese obtained in Mexico. (cdc.gov)
  • In 2016, CDC identified a multidrug-resistant (MDR) strain of Salmonella enterica serotype Newport that is now monitored as a persisting strain (REPJJP01). (cdc.gov)
  • In 2016, CDC identified a multidrug-resistant (MDR) strain of Salmonella enterica serotype Newport that is now monitored as a persisting strain* named REPJJP01 and includes isolates from U.S. residents in all 50 states and the District of Columbia. (cdc.gov)
  • The pooled prevalence of multidrug resistant strains identified was 59.7% (95% CI: 43.5-75.9). (hindawi.com)
  • In developing countries, factors such as inadequate access to effective drugs, unregulated dispensing and manufacture of antimicrobials, and truncated antimicrobial therapy because of cost are contributing to the development of multidrug-resistant organisms. (jabfm.org)
  • 1-3 Multiple poverty-driven factors that contribute to the development of multidrug-resistant organisms have been identified, some of which may be directly affecting resistance in the United States. (jabfm.org)
  • This problem of multidrug-resistant organisms in developing countries can also directly affect and threaten more developed countries (such as the United States) because international travel, driven by globalized trade, allows for easier dissemination of these strains. (jabfm.org)
  • Reasons for multidrug-resistant organisms in developing countries are numerous, but the inadequate access to effective drugs, the unregulated manufacture and dispensation of antimicrobials, and the lack of money available to pay for appropriate, high-quality medications are some of the major poverty-driven factors contributing to antimicrobial resistance. (jabfm.org)
Penicillin-resistant strains2
  • Penicillin-resistant strains also are resistant to amoxicillin, but higher doses may be effective. (medscape.com)
  • whilst chromosomally mediated penicillin-resistant strains increased dramatically from 0 to 16 from 1984 to 2004. (bvsalud.org)
Salmonella4
  • Of 585 isolates tested, 46 (7.9%) were resistant treatment of persons with nontyphoidal Salmonella in- to third-generation cepalosporins. (cdc.gov)
  • Salmonella group B resistant to ceftriaxone emerged in 2009 and 2010 (6.2% [2/32 isolates]), rising to 56.5% (13/23 isolates) in 2012 and 2013. (nih.gov)
  • Rapidly emerging resistance against ceftriaxone requires urgent reevaluation of antibiotic recommendations and primary prevention of exposure to Salmonella. (nih.gov)
  • Federal official are investigating an outbreak of antibiotic-resistant Salmonella that has sickened at least 92 people and had been traced to raw chicken from multiple sources and sold under various brands. (foodsafetynews.com)
Injection8
  • Ceftriaxone for Injection, USP is a white to yellowish-orange crystalline powder which is readily soluble in water, sparingly soluble in methanol and very slightly soluble in ethanol. (nih.gov)
  • The color of Ceftriaxone for Injection, USP solutions ranges from light yellow to amber, depending on the length of storage, concentration and diluent used. (nih.gov)
  • Ceftriaxone for Injection, USP contains approximately 83 mg (3.6 mEq) of sodium per gram of ceftriaxone activity. (nih.gov)
  • Ceftriaxone injection comes as a powder to be mixed with liquid, or as a premixed product, to be injected intravenously (into a vein) over a period of 30 or 60 minutes.Ceftriaxone injection can also be given intramuscularly (into a muscle). (medlineplus.gov)
  • You may receive ceftriaxone injection in a hospital or doctor's office, or you may administer the medication at home. (medlineplus.gov)
  • If you will be receiving ceftriaxone injection at home, your healthcare provider will show you how to use the medication. (medlineplus.gov)
  • You should begin to feel better during the first few days of your treatment with ceftriaxone injection. (medlineplus.gov)
  • Your doctor may not want your baby to receive ceftriaxone injection. (epnet.com)
Treatment2
  • Ceftriaxone remains an appropriate empiric treatment option for patients who traveled to countries other than Pakistan and Iraq. (cdc.gov)
  • Ceftriaxone remains the gold standard treatment. (medicaljournals.se)
Rocephin1
Gentamicin1
  • Gentamicin cannot therefore be recommended to replace ceftriaxone as first-line therapy for gonorrhoea," the authors of the study write. (umn.edu)
Carbapenem-resistant1
  • Entasis currently estimates the trial is approximately 90% enrolled, as microbiological analyses have confirmed 108 carbapenem-resistant evaluable patients out of the target of 120 evaluable patients necessary for completion of the trial, with another 16 enrolled patients pending confirmation. (biospace.com)
Fluoroquinolone-resistant1
  • All 29 fluoroquinolone-resistant isolates were positive for the aac(6')-Ib-cr gene but negative for qepA , except SD001. (researchsquare.com)
Organisms2
  • The rapid and ongoing spread of antimicrobial-resistant organisms threatens our ability to successfully treat a growing number of infectious diseases. (hindawi.com)
  • Concerningly, these resistant organisms can spread from farm animals to humans, creating a bigger health crisis. (phys.org)
Shigella2
  • and review what CDC is doing to learn more about extensively drug-resistant Shigella in the United States and how clinicians and public health officials can help through testing and reporting. (cdc.gov)
  • The widespread distribution of antimicrobial-resistant Shigella has become a recurrent challenge in many parts of the developing world. (researchsquare.com)
Extensively2
  • I'd like to welcome you to today's COCA call, Epidemiology, Testing, and Management of Extensively Drug-Resistant Shigellosis. (cdc.gov)
  • Need to Know About Extensively Drug-Resistant Shigellosis in the United States. (cdc.gov)
Typhoid1