CiprofloxacinPenicillinAzithromycinSusceptibility to ceftriaxoneTetracyclineIndicate that ceftriaxoneGonorrhoeaeCefixime and ceftriaxoneAntibioticDoxycyclineStrainsIsolates were sensitiveDoseCefoxitinCeftiofurResistantSubsequentlyTreatmentInfectionsRibosomeInjectionPregnant womenEffectiveValuesIsolatesResistant to ceftriaxoneStrainsResistanceAntimicrobialGonorrheaPharyngealUnavailablePatients
Ciprofloxacin9
- The antibiotics currently routinely surveyed are penicillin, ceftriaxone, ciprofloxacin and spectinomycin, all of which are administered as single dose regimens and currently used in Australia to treat gonorrhoea. (health.gov.au)
- Uncomplicated Gonococcal Infections Recommended Regimens - Ceftriaxone 125 mg IM in a single dose or Cefixime 400 mg orally in a single dose or Ciprofloxacin 500 mg orally in a single dose or Ofloxacin 400 mg orally in a single dose PLUS A regimen effective against possible coinfection with C. trachomatis, such as doxycycline 100 mg orally 2 times a day for 7 days. (cdc.gov)
- Published studies indicate that ceftriaxone 125 mg and ciprofloxacin 500 mg can cure greater than or equal to 90% of pharyngeal infections. (cdc.gov)
- Susceptibility of N. gonorrhoeae to five antibiotics (ciprofloxacin, ceftriaxone, spectinomycin, penicillin G and tetracycline) was tested systematically. (medicaljournals.se)
- The antibiotics which are currently routinely surveyed are the penicillins, ceftriaxone, ciprofloxacin and spectinomycin, all of which are administered as single dose regimens. (health.gov.au)
- Etest was used to determine the susceptibility to ceftriaxone, ciprofloxacin, penicillin and spectinomycin. (warwick.ac.uk)
- Results No isolates displayed resistance to spectinomycin and ceftriaxone, whereas 79.1% and 37.4% were resistant to penicillin and ciprofloxacin, respectively. (warwick.ac.uk)
- Common genomic determinants defined most strains' phenotypic, reduced susceptibility to current and historic antibiotics (e.g. bla (TEM) plasmid for penicillin, tetM plasmid for tetracycline, gyrA for ciprofloxacin, 23S rRNA and/or mosaic mtr operon for azithromycin, and mosaic penA for cefixime and ceftriaxone). (cdc.gov)
- Treatment with enrofloxacin resulted in selection of isolates that offered phenotypic resistance to both ciprofloxacin and ceftriaxone. (biosemiotics2013.org)
Penicillin5
- The results of the present surveillance initiated in 2009 were also used to replace penicillin G with ceftriaxone (1 g single dose intramuscularly) as the first-line drug for empiric treatment of gonorrhoea in the national treatment guidelines in Belarus in late 2009. (biomedcentral.com)
- Comparison of ceftriaxone with cefoxitin in the treatment of penicillin-resistant gonococcal urethritis. (bmj.com)
- Ceftriaxone was completely effective in treating both penicillin-sensitive and penicillin-resistant gonococcal urethritis. (bmj.com)
- Ceftriaxone thus seems to be an effective and safe alternative to either spectinomycin or cefoxitin in the treatment of penicillin-resistant gonococcal urethritis. (bmj.com)
- 2009) observed that calves in a conventional therapy group treated as per dairy protocol with sulfamethoxazole-trimethoprim spectinomycin penicillin and bismuth-pectin for diarrhea experienced 70% more days with diarrhea than calves in the targeted therapy group treated with bismuth-pectin for diarrhea and antimicrobial treatment only in instances of fever or stressed out attitude. (biosemiotics2013.org)
Azithromycin6
- Among isolates tested for susceptibility to other antimicrobial agents, no evidence was found of decreased susceptibility to ceftriaxone, cefixime, or azithromycin, or resistance to spectinomycin. (cdc.gov)
- Because dual therapy with ceftriaxone plus azithromycin is the only recommended gonorrhea treatment, increases in azithromycin and cephalosporin MICs are cause for concern that resistance to these antimicrobial agents might be emerging. (cdc.gov)
- The first line treatment for gonorrhea is a combination of azithromycin and ceftriaxone. (coloringfolder.com)
- Azithromycin is taken orally in a single dose while ceftriaxone is administered by injection. (coloringfolder.com)
- Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018. (lshtm.ac.uk)
- We describe a gonorrhoea case with combined high-level azithromycin resistance and ceftriaxone resistance. (lshtm.ac.uk)
Susceptibility to ceftriaxone1
- Of the 9 antimicrobial medicines used on study farms only enrofloxacin was significantly associated with reduced antimicrobial susceptibility of isolates although treatment with ceftiofur was associated with reduced susceptibility to ceftriaxone. (biosemiotics2013.org)
Tetracycline1
- Zoliflodacin was evaluated alone or combined with ceftriaxone, cefixime, spectinomycin, gentamicin, tetracycline, cethromycin or sitafloxacin in chequerboard assays, time-kill curve analysis and selection-of-resistance studies. (birmingham.ac.uk)
Indicate that ceftriaxone1
- The results of this surveillance indicate that ceftriaxone and spectinomycin, which are currently recommended for gonococcal infections in Japan, appear to be effective. (bvsalud.org)
Gonorrhoeae5
- No ceftriaxone-resistant strains of N. gonorrhoeae have been reported. (cdc.gov)
- Ceftriaxone and spectinomycin demonstrated lower MICs and so are recommended for N gonorrhoeae . (bmj.com)
- All N. gonorrhoeae were susceptible to ceftriaxone and spectinomycin. (medicaljournals.se)
- Since cefoxitin has been shown to be an effective alternative to spectinomycin for the treatment of infections due to penicillinase-producing strains of Neisseria gonorrhoeae (PPNG) its efficacy was compared with that of a new cephalosporin, ceftriaxone (R013-9904). (bmj.com)
- The AGSP laboratories examined 840 isolates of Neisseria gonorrhoeae for sensitivity to the penicillins, ceftriaxone, quinolones and spectinomycin and for high level resistance to the tetracyclines in the September quarter of 1998. (health.gov.au)
Cefixime and ceftriaxone2
- MIC 90 values for cefixime and ceftriaxone and were 0.5 μg/ml and 0.0063 μg/ml. (bmj.com)
- One isolate carried the penA 60.001 allele resulting in elevated MICs to cefixime and ceftriaxone of 1.0 g ml(-1). (cdc.gov)
Antibiotic3
- The percentage of isolates with elevated cefixime MICs increased during 2009-2010, then decreased during 2012-2013 after treatment recommendations were changed in 2010 to recommend dual therapy (with a cephalosporin and a second antibiotic) and a higher dosage of ceftriaxone. (cdc.gov)
- a systematic review concerning treatment of gonorrhoea in pregnancy (1) found that various antibiotic treatments (amoxicillin plus probenecid, spectinomycin, ceftriaxone, cefixime) were effective for curing gonorrhoea in pregnant women. (gpnotebook.com)
- Single daily dosing ceftriaxone and metronidazole vs standard triple antibiotic regimen for perforated appendicitis in children: a prospective randomized trial. (jefferson.edu)
Doxycycline4
- Current CDC guidelines recommend a higher single dose of 500 mg ceftriaxone IM for GU (1 g for men ≥ 150 kg), and doxycycline 100 mg orally twice daily for 7 days for NGU. (medscape.com)
- Ceftriaxone also may abort incubating syphilis, a concern when gonorrhea treatment is not accompanied by a 7-day course of doxycycline or erythromycin for the presumptive treatment of chlamydia. (cdc.gov)
- In February 2018, a heterosexual male was diagnosed with gonorrhoea in the United Kingdom following sexual intercourse with a locally resident female in Thailand and failed treatment with ceftriaxone plus doxycycline and subsequently spectinomycin. (lshtm.ac.uk)
- Management generally involves ceftriaxone, but treatment with doxycycline should be pursued if a coinfection with Chlamydia trachomatis ( C. trachomatis ) is not excluded. (lecturio.com)
Strains1
- None of the strains were resistant to ceftriaxone or spectinomycin. (bvsalud.org)
Isolates were sensitive4
- All isolates were sensitive to the third generation cephalosporins and only a very few isolates in China were spectinomycin resistant. (health.gov.au)
- All isolates were sensitive to ceftriaxone and 90.8% of them were sensitive to cefixime. (bmj.com)
- MIC 90 for spectinomycin was 32 μg/ml and all isolates were sensitive to it. (bmj.com)
- Seventy-eight per cent (78 per cent) of the isolates were sensitive to Spectinomycin. (bvsalud.org)
Dose4
- Ceftriaxone in a single dose of either 125 mg or 250 mg provides sustained, high bactericidal levels in the blood. (cdc.gov)
- Cefixime has an antimicrobial spectrum similar to that of ceftriaxone, but the 400 mg oral dose does not provide as high nor as sustained a bactericidal level as does 125 mg of ceftriaxone. (cdc.gov)
- The 500-mg IM dose of ceftriaxone is recommended over previous dosing, given concern for resistance, prior lower-dose ceftriaxone dose failures, and seemingly improved efficacy in pharyngeal infections. (medscape.com)
- If ceftriaxone is unavailable, patients can be given a single dose of cefixime 800 mg PO. (medscape.com)
Cefoxitin1
- One hundred and twenty eight men with culture-confirmed gonococcal urethritis were treated with either 250 mg of ceftriaxone intramuscularly or 2 g of cefoxitin intramuscularly with oral probenecid 1 g. (bmj.com)
Ceftiofur1
- Treatment with ceftiofur resulted in an odds percentage of 3 (95% CI: 0.9-12) for isolation of nonsusceptible to ceftriaxone compared with calves not treated with ceftiofur. (biosemiotics2013.org)
Resistant2
- No isolates resistant to ceftriaxone and spectinomycin were identified. (biomedcentral.com)
- One isolate was resistant to cefixime, but no resistance to ceftriaxone or spectinomycin was found. (biomedcentral.com)
Subsequently1
Treatment2
- Ceftriaxone remains the gold standard treatment. (medicaljournals.se)
- Because of resistance with oral cephalosporins, only one regimen, treatment with ceftriaxone IM, is recommended as first-line for treatment of gonorrhea in the United States. (medscape.com)
Infections1
- Ceftriaxone is used to treat a variety of bacterial infections. (jiulongpharmaceutical.com)
Ribosome1
- Spectinomycin binds to the 30S subunit of the ribosome, thus inhibiting bacterial protein synthesis. (msdmanuals.com)
Injection1
- The drawbacks of ceftriaxone are that it is expensive, currently unavailable in vials of less than 250 mg, and must be administered by injection. (cdc.gov)
Pregnant women1
- Ceftriaxone is safe and effective in pregnant women and probably destroys incubating syphilis. (medscape.com)
Effective1
- Spectinomycin is not effective for gonococcal pharyngitis. (msdmanuals.com)
Values1
- the minimum inhibitory concentration values for spectinomycin were very close to the breakpoint. (bvsalud.org)
Isolates11
- All isolates were sensitive to ceftriaxone and 90.8% of them were sensitive to cefixime. (bmj.com)
- MIC 90 for spectinomycin was 32 μg/ml and all isolates were sensitive to it. (bmj.com)
- All isolates in Australia were again susceptible to these injectable agents, with the exception of one strain with decreased ceftriaxone susceptibility. (health.gov.au)
- Worryingly, gonococcal isolates with resistance to spectinomycin, which are exceedingly rare internationally, were identified in all the surveyed years and in four of the seven Federal Districts of Russia. (micrornaassay.com)
- In earlier Russian studies, spectinomycin resistant gonococcal isolates have also been found in all the seven Federal Districts of Russia. (micrornaassay.com)
- In the present study, the spectinomycin resistant isolates Inhibitors,Modulators,Libraries (n _ 50 belonged to 32 different STs. (micrornaassay.com)
- Fortunately, the resistant isolates had a spectinomycin MIC of maximum 128 256 mg L and no isolates with high level resistance to spectinomycin (MIC 1024 mg L have yet been found in Russia. (micrornaassay.com)
- Using the CLSI breakpoints, all isolates from 2009 to Inhibitors,Modulators,Libraries 2012 were susceptible to ceftriaxone (MIC 0. (micrornaassay.com)
- 125 mg L. Interestingly, the prevalence of these ceftriaxone resistant isolates decreased significantly Inhibitors,Modulators,Libraries (P 0. (micrornaassay.com)
- Still no treatment failure of gonorrhoea with ceftriaxone has been verified in Russia, however, isolates with a ceftriaxone MIC of 0. (micrornaassay.com)
- Of the 9 antimicrobial medicines used on study farms only enrofloxacin was significantly associated with reduced antimicrobial susceptibility of isolates although treatment with ceftiofur was associated with reduced susceptibility to ceftriaxone. (biosemiotics2013.org)
Resistant to ceftriaxone2
- None of the strains were resistant to ceftriaxone or spectinomycin. (bvsalud.org)
- 25 mg L. However, using the European EUCAST breakpoint were resistant to ceftriaxone (MIC 0. (micrornaassay.com)
Strains3
- We investigated the possible spread of a ceftriaxone-resistant FC428 N. gonorrhoeae clone in Japan after recent isolation of similar strains in Denmark (GK124) and Canada (47707). (nih.gov)
- No ceftriaxone-resistant strains of N. gonorrhoeae have been reported. (cdc.gov)
- Accordingly, they did not represent any clonal spread and spectinomycin resistance has been selected in many different gonococcal strains. (micrornaassay.com)
Resistance5
- Occasional chromosomal-mediated resistance to spectinomycin has also been reported. (cdc.gov)
- and harboring of mosaic penA allele encoding alterations A311V and T483S (penA-60.001), associated with ceftriaxone resistance. (nih.gov)
- Because of resistance with oral cephalosporins, only one regimen, treatment with ceftriaxone IM, is recommended as first-line for treatment of gonorrhea in the United States. (medscape.com)
- The 500-mg IM dose of ceftriaxone is recommended over previous dosing, given concern for resistance, prior lower-dose ceftriaxone dose failures, and seemingly improved efficacy in pharyngeal infections. (medscape.com)
- The molecular mechanisms for this low level resistance to spectinomycin are commonly specific amino acid alterations in the ribosomal protein S5, which has been selected by frequent use of spectinomycin. (micrornaassay.com)
Antimicrobial1
- Cefixime has an antimicrobial spectrum similar to that of ceftriaxone, but the 400 mg oral dose does not provide as high nor as sustained a bactericidal level as does 125 mg of ceftriaxone. (cdc.gov)
Gonorrhea3
- Antibiotics used to treat Gonorrhea include ceftriaxone, cefiximine and spectinomycin. (womens-health.co.uk)
- Ceftriaxone also may abort incubating syphilis, a concern when gonorrhea treatment is not accompanied by a 7-day course of doxycycline or erythromycin for the presumptive treatment of chlamydia. (cdc.gov)
- Spectinomycin may be costly, have limited efficacy against pharyngeal gonorrhea, and currently is unavailable in the United States. (medscape.com)
Pharyngeal1
- 25 mg L have resulted in failures to treat pharyngeal gonorrhoea with ceftriaxone in other countries. (micrornaassay.com)
Unavailable1
- The drawbacks of ceftriaxone are that it is expensive, currently unavailable in vials of less than 250 mg, and must be administered by injection. (cdc.gov)
Patients1
- Another alternative regimen for patients intolerant of cephalosporins is spectinomycin (2 g IM). (medscape.com)