• The results of the present surveillance initiated in 2009 were also used to replace penicillin G with ceftriaxone (1 g single dose intramuscularly) as the first-line drug for empiric treatment of gonorrhoea in the national treatment guidelines in Belarus in late 2009. (biomedcentral.com)
  • Comparison of ceftriaxone with cefoxitin in the treatment of penicillin-resistant gonococcal urethritis. (bmj.com)
  • Ceftriaxone was completely effective in treating both penicillin-sensitive and penicillin-resistant gonococcal urethritis. (bmj.com)
  • Ceftriaxone thus seems to be an effective and safe alternative to either spectinomycin or cefoxitin in the treatment of penicillin-resistant gonococcal urethritis. (bmj.com)
  • 2009) observed that calves in a conventional therapy group treated as per dairy protocol with sulfamethoxazole-trimethoprim spectinomycin penicillin and bismuth-pectin for diarrhea experienced 70% more days with diarrhea than calves in the targeted therapy group treated with bismuth-pectin for diarrhea and antimicrobial treatment only in instances of fever or stressed out attitude. (biosemiotics2013.org)
  • Of the 9 antimicrobial medicines used on study farms only enrofloxacin was significantly associated with reduced antimicrobial susceptibility of isolates although treatment with ceftiofur was associated with reduced susceptibility to ceftriaxone. (biosemiotics2013.org)
  • The results of this surveillance indicate that ceftriaxone and spectinomycin, which are currently recommended for gonococcal infections in Japan, appear to be effective. (bvsalud.org)
  • The percentage of isolates with elevated cefixime MICs increased during 2009-2010, then decreased during 2012-2013 after treatment recommendations were changed in 2010 to recommend dual therapy (with a cephalosporin and a second antibiotic) and a higher dosage of ceftriaxone. (cdc.gov)
  • a systematic review concerning treatment of gonorrhoea in pregnancy (1) found that various antibiotic treatments (amoxicillin plus probenecid, spectinomycin, ceftriaxone, cefixime) were effective for curing gonorrhoea in pregnant women. (gpnotebook.com)
  • Single daily dosing ceftriaxone and metronidazole vs standard triple antibiotic regimen for perforated appendicitis in children: a prospective randomized trial. (jefferson.edu)
  • Current CDC guidelines recommend a higher single dose of 500 mg ceftriaxone IM for GU (1 g for men ≥ 150 kg), and doxycycline 100 mg orally twice daily for 7 days for NGU. (medscape.com)
  • Ceftriaxone also may abort incubating syphilis, a concern when gonorrhea treatment is not accompanied by a 7-day course of doxycycline or erythromycin for the presumptive treatment of chlamydia. (cdc.gov)
  • In February 2018, a heterosexual male was diagnosed with gonorrhoea in the United Kingdom following sexual intercourse with a locally resident female in Thailand and failed treatment with ceftriaxone plus doxycycline and subsequently spectinomycin. (lshtm.ac.uk)
  • Management generally involves ceftriaxone, but treatment with doxycycline should be pursued if a coinfection with Chlamydia trachomatis ( C. trachomatis ) is not excluded. (lecturio.com)
  • Ceftriaxone in a single dose of either 125 mg or 250 mg provides sustained, high bactericidal levels in the blood. (cdc.gov)
  • Cefixime has an antimicrobial spectrum similar to that of ceftriaxone, but the 400 mg oral dose does not provide as high nor as sustained a bactericidal level as does 125 mg of ceftriaxone. (cdc.gov)
  • The 500-mg IM dose of ceftriaxone is recommended over previous dosing, given concern for resistance, prior lower-dose ceftriaxone dose failures, and seemingly improved efficacy in pharyngeal infections. (medscape.com)
  • If ceftriaxone is unavailable, patients can be given a single dose of cefixime 800 mg PO. (medscape.com)
  • One hundred and twenty eight men with culture-confirmed gonococcal urethritis were treated with either 250 mg of ceftriaxone intramuscularly or 2 g of cefoxitin intramuscularly with oral probenecid 1 g. (bmj.com)
  • Treatment with ceftiofur resulted in an odds percentage of 3 (95% CI: 0.9-12) for isolation of nonsusceptible to ceftriaxone compared with calves not treated with ceftiofur. (biosemiotics2013.org)
  • Subsequently, the treatment recommendations were changed again in 2012 to no longer recommend cefixime as part of first-line therapy (leaving ceftriaxone-based dual therapy as the only recommended therapy). (cdc.gov)
  • Spectinomycin binds to the 30S subunit of the ribosome, thus inhibiting bacterial protein synthesis. (msdmanuals.com)
  • The drawbacks of ceftriaxone are that it is expensive, currently unavailable in vials of less than 250 mg, and must be administered by injection. (cdc.gov)
  • Ceftriaxone is safe and effective in pregnant women and probably destroys incubating syphilis. (medscape.com)
  • Spectinomycin is not effective for gonococcal pharyngitis. (msdmanuals.com)
  • All isolates were sensitive to ceftriaxone and 90.8% of them were sensitive to cefixime. (bmj.com)
  • MIC 90 for spectinomycin was 32 μg/ml and all isolates were sensitive to it. (bmj.com)
  • All isolates in Australia were again susceptible to these injectable agents, with the exception of one strain with decreased ceftriaxone susceptibility. (health.gov.au)
  • Worryingly, gonococcal isolates with resistance to spectinomycin, which are exceedingly rare internationally, were identified in all the surveyed years and in four of the seven Federal Districts of Russia. (micrornaassay.com)
  • In earlier Russian studies, spectinomycin resistant gonococcal isolates have also been found in all the seven Federal Districts of Russia. (micrornaassay.com)
  • In the present study, the spectinomycin resistant isolates Inhibitors,Modulators,Libraries (n _ 50 belonged to 32 different STs. (micrornaassay.com)
  • Fortunately, the resistant isolates had a spectinomycin MIC of maximum 128 256 mg L and no isolates with high level resistance to spectinomycin (MIC 1024 mg L have yet been found in Russia. (micrornaassay.com)
  • Using the CLSI breakpoints, all isolates from 2009 to Inhibitors,Modulators,Libraries 2012 were susceptible to ceftriaxone (MIC 0. (micrornaassay.com)
  • 125 mg L. Interestingly, the prevalence of these ceftriaxone resistant isolates decreased significantly Inhibitors,Modulators,Libraries (P 0. (micrornaassay.com)
  • Still no treatment failure of gonorrhoea with ceftriaxone has been verified in Russia, however, isolates with a ceftriaxone MIC of 0. (micrornaassay.com)
  • Of the 9 antimicrobial medicines used on study farms only enrofloxacin was significantly associated with reduced antimicrobial susceptibility of isolates although treatment with ceftiofur was associated with reduced susceptibility to ceftriaxone. (biosemiotics2013.org)
  • We investigated the possible spread of a ceftriaxone-resistant FC428 N. gonorrhoeae clone in Japan after recent isolation of similar strains in Denmark (GK124) and Canada (47707). (nih.gov)
  • No ceftriaxone-resistant strains of N. gonorrhoeae have been reported. (cdc.gov)
  • Accordingly, they did not represent any clonal spread and spectinomycin resistance has been selected in many different gonococcal strains. (micrornaassay.com)
  • Occasional chromosomal-mediated resistance to spectinomycin has also been reported. (cdc.gov)
  • and harboring of mosaic penA allele encoding alterations A311V and T483S (penA-60.001), associated with ceftriaxone resistance. (nih.gov)
  • Because of resistance with oral cephalosporins, only one regimen, treatment with ceftriaxone IM, is recommended as first-line for treatment of gonorrhea in the United States. (medscape.com)
  • The 500-mg IM dose of ceftriaxone is recommended over previous dosing, given concern for resistance, prior lower-dose ceftriaxone dose failures, and seemingly improved efficacy in pharyngeal infections. (medscape.com)
  • The molecular mechanisms for this low level resistance to spectinomycin are commonly specific amino acid alterations in the ribosomal protein S5, which has been selected by frequent use of spectinomycin. (micrornaassay.com)
  • Cefixime has an antimicrobial spectrum similar to that of ceftriaxone, but the 400 mg oral dose does not provide as high nor as sustained a bactericidal level as does 125 mg of ceftriaxone. (cdc.gov)
  • The drawbacks of ceftriaxone are that it is expensive, currently unavailable in vials of less than 250 mg, and must be administered by injection. (cdc.gov)