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PiperacillinPenicillanic AcidCeftazidimeImipenemAnti-Bacterial AgentsMicrobial Sensitivity Testsbeta-LactamasesThienamycinsbeta-LactamsCephalosporinsPenicillinsGram-Negative BacteriaTicarcillinClavulanic AcidPseudomonas aeruginosaCilastatinCarbapenemsBacterial InfectionsDrug Therapy, CombinationSulbactamGram-Negative Bacterial InfectionsPseudomonas InfectionsTobramycinLuxembourgLactamsDrug Resistance, Multiple, BacterialKlebsiella pneumoniaeKlebsiella InfectionsCross InfectionChemotherapy-Induced Febrile NeutropeniaMannansAztreonambeta-Lactam ResistanceDrug Resistance, BacterialCiprofloxacinBacteriaAbdominal AbscessBacteroides fragilisClavulanic AcidsGram-Positive BacteriaEnterobacteriaceaeAnti-Infective AgentsAmikacinEnterobacter cloacaeDrug Resistance, MicrobialCefotaximeEscherichia coli InfectionsCarbenicillinMonobactamsBacteremiaCefoperazonePeritonitisCefoxitinFalse Positive ReactionsEscherichia coliCephalosporin ResistanceCephalosporinaseAcinetobacterIntensive Care UnitsEnterobacteriaceae InfectionsWound InfectionAcinetobacter baumanniiGentamicinsKlebsiellaEnzyme InhibitorsBacteria, AnaerobicMoxalactamAspergillosisCitrobacter freundiiAmpicillinIsoelectric FocusingAzlocillinCeftriaxoneHalf-LifeAcinetobacter InfectionsMicrobial ViabilityDrug SynergismDrug CombinationsFloxacillinMezlocillinInfusions, IntravenousCephalothinPneumonia, BacterialAzabicyclo CompoundsEnterobacterMelioidosisRespiratory Tract InfectionsNetilmicinAminoglycosidesPenicillin ResistanceBacterial ProteinsDrug IncompatibilityBlisterPenicillin-Binding ProteinsTreatment OutcomeAgranulocytosisMuramoylpentapeptide CarboxypeptidaseSerum Bactericidal TestFeverProspective Studies

MeropenemAmikacinCiprofloxacinCeftriaxoneCarbapenemsIsolatesTicarcillinResistanceAvibactamAntibioticsCefepimeAztreonamCephalosporinsPseudomonasZosynSensitivityAeruginosaVitro activityPenicillinSusceptibleGramPatients

Meropenem3

• A patient-specific, clinically significant reason why the member cannot use an appropriate penicillin-beta lactamase inhibitor combination (e.g. piperacillin-tazobactam), a carbapenam (e.g. ertapenem, meropenem, imipenem-cilastatin), a cephalosporin (e.g. ceftriaxone, ceftazidime) in combination with metronidazole, or other cost effective therapeutic equivalent medication(s). (oklahoma.gov)
• Imipenem/cilastatin/relebactam and meropenem/vaborbactam require PA because of safety concerns and to ensure appropriate utilization. (conduent.com)
• CRKP was defined as isolates having a minimum inhibitory concentration (MIC) ≥2 μg/ml against ertapenem meropenem or imipenem and a positive modified Hodge test (Clinical and Laboratory Standards Institute (CLSI) 2009). (academicediting.org)

Amikacin3

• Based on the results, 5.26% of the tested isolates were co-resistant to ceftazidime, amikacin, and piperacillin/tazobactam. (brieflands.com)
• [3] , [4] Thus, suitable drugs against P. aeruginosa infections are limited to aminoglycosides (e.g., amikacin), fluoroquinolones (ciprofloxacin remains the most active), selected β-lactams (e.g., ceftazidime and carbapenems) and one β-lactam/β-lactamase inhibitor combination (piperacillin/tazobactam). (advbiores.net)
• Antimicrobial susceptibility testing was performed on CRKP isolates including the U 95666E following antibiotics: ciprofloxacin amikacin gentamicin ceftazidime piperacillin-tazobactam doxycycline tigecycline and colistin. (academicediting.org)

Ciprofloxacin1

• Phenotypic resistance against β-lactams (ceftazidime, cefotaxime, aztreonam and ceftriaxone) and fluoroquinolones (ciprofloxacin) were identified by the disc diffusion technique. (biomedcentral.com)

Ceftriaxone1

• 70%) of ceftriaxone and ceftazidime-resistant Klebsiella were also observed. (biomedcentral.com)

Carbapenems1

• was found out to correlate using the consumptions of carbapenems favorably, extended-spectrum cephalosporins, aminopenicillins/-lactamase inhibitors, fluoroquinolones and piperacillin/tazobactam, and correlate using the consumptions of non-extended-spectrum cephalosporins adversely, aminoglycosides and penicillins. (irpa2006europe.com)

Isolates3

• Susceptibility to ceftazidime, ticarcillin, imipenem, and piperacillin/tazobactam were higher among isolates obtained from non-ICU patients. (magiran.com)
• Ceftazidime-resistant (CAZ res ) isolates with a positive double-disc synergy test were screened for the presence of extended-spectrum β-lactamase-encoding genes. (advbiores.net)
• Phenotypic tests to detect the metallo-β-lactamase strains of P. aeruginosa were performed on imipenem-resistant (IMP res ) isolates. (advbiores.net)

Ticarcillin1

• 81% of P. aeruginosa isolateswere sensitive to piperacillin/tazobactam and ticarcillin, while 60% were resistant to third generation of cephalosporins. (magiran.com)

Resistance1

• Ureido-penicillins, cephalosporins, aminoglycosides, imipenem, trimethoprim-sulfamethoxazole are the drugs of choice to treat P. vulgaris associate infections but it possess high level of resistance against penicillin and other antibiotics[4]. (slideserve.com)

Avibactam1

• Cefiderocol, ceftazidime/avibactam, and ceftolozane/tazobactam require PA because of safety concerns and to ensure appropriate utilization. (conduent.com)

Antibiotics1

• had been powered by consumptions of broad-spectrum antibiotics apart from piperacillin/tazobactam. (irpa2006europe.com)

Cefepime1

• ceftazidime or cefepime PLUS metronidazole . (hopkinsguides.com)

Aztreonam3

• and Proteus mirabilis was evaluated, using incidence rates of resistance mechanisms to third-generation cephalosporins, aztreonam, and piperacillin-tazobactam seen across U.S. census regions. (nih.gov)
• Overall, the presence of CTX-M, KPC, and/or NDM genes was 81% (range, 57 to 87%) sensitive for the prediction of ceftriaxone, ceftazidime, and aztreonam resistance and 73% (range, 25 to 90%) sensitive for the detection of piperacillin-tazobactam resistance. (nih.gov)
• 2017. An unusual E. coli PBP3 insertion sequence identified from a collection of carbapenem-resistant Enterobacteriaceae (CRE) tested in vitro with ceftazidime-, ceftaroline- or aztreonam-avibactam combinations . (indiana.edu)

Cephalosporins1

• Aminoglycosides or advanced generation cephalosporins, e.g., ceftazidime/avibactam , may be required if resistant Gram negatives are isolated/suspected. (hopkinsguides.com)

Pseudomonas1

• Ceftazidime has good activity against Pseudomonas aeruginosa and most gram negative bacilli. (pedsoncologyeducation.com)

Zosyn5

• The usual total daily dose of Zosyn for adults is 3.375 g every six hours totaling 13.5 g (12.0 g piperacillin/1.5 g tazobactam). (rxlist.com)
• Our Zosyn (piperacillin and tazobactam for injection, USP) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
• ZOSYN (piperacillin and tazobactam) for Injection and ZOSYN (piperacillin and tazobactam) Injection are injectable antibacterial combination products consisting of the semisynthetic antibacterial piperacillin sodium and the β-lactamase inhibitor tazobactam sodium for intravenous administration. (rxlist.com)
• ZOSYN (piperacillin and tazobactam) for Injection, is a white to off-white sterile, cryodesiccated powder consisting of piperacillin and tazobactam as their sodium salts packaged in glass vials. (rxlist.com)
• Each ZOSYN 2.25 g single dose vial contains an amount of drug sufficient for withdrawal of piperacillin sodium equivalent to 2 grams of piperacillin and tazobactam sodium equivalent to 0.25 g of tazobactam. (rxlist.com)

Sensitivity1

• Ceftolozane/tazobactam remained cost-effective at a willingness to pay of $100,000 per QALY compared to piperacillin/tazobactam over a range of input parameter values during one-way and probabilistic sensitivity analysis. (biomedcentral.com)

Aeruginosa1

• All the multidrug resistant P. aeruginosa were phenotypically screened for MBL producer by Imipenem-EDTA combined disc diffusion test (CDDT). (biomedcentral.com)

Vitro activity1

• Imipenem has better in vitro activity for Gram positive organisms. (pedsoncologyeducation.com)

Penicillin2

• Piperacillin sodium is derived from D(-)-α-aminobenzyl- penicillin . (rxlist.com)
• Tazobactam sodium, a derivative of the penicillin nucleus, is a penicillanic acid sulfone. (rxlist.com)

Susceptible1

• nevertheless, they are still susceptible to tazobactam . (wikidoc.org)

Gram1

• A decision-analytic Monte Carlo simulation model was developed to compare the costs and effectiveness of empiric treatment with either ceftolozane/tazobactam or piperacillin/tazobactam in hospitalized adult patients with cUTI infected with Gram-negative pathogens in the US. (biomedcentral.com)

Patients1

• Model results show that ceftolozane/tazobactam is likely to be cost-effective compared with piperacillin/tazobactam for the empiric treatment of hospitalized cUTI patients in the United States. (biomedcentral.com)