AmpicillinChloramphenicolIsolatesCephalosporinsSodiumResistantMefoxinSusceptibilityOxacillinAntibioticsAntibioticCephamycinSusceptibleCephaloridineImipenemGramInjectionSemi-syntheticEffectiveResultsDrugsCephamycinsAcquired resistanceBeta-lactamaseCephaloridinePBPsHydrolysisBacteriaPenicillinClinicalApproximately
Ampicillin3
- Similarly, many infections caused by aerobic and anaerobic bacteria resistant to some penicillin antibiotics (ampicillin, carbenicillin, penicillin G) respond to treatment with cefoxitin for injection, USP. (wikidoc.org)
- Resistance rates in CNS were high, with 39% of isolates exhibiting resistance to ampicillin and penicillin, 6% of isolates being resistant to amoxicillin with clavulanic acid, ceftiofur, cephalothin, and cefoxitin, and 5 % being resistant to erythromycin. (gstsvs.ch)
- Insgesamt betrachtet lag der Anteil resistenter CNS hoch, wobei 39 % der Isolate als resistent gegen Ampicillin und Penicillin, 6 % als resistent gegen Amoxicillin mit Clavulansäure, Ceftiofur, Cephalothin und Cefoxitin und 5 % als resistent gegen Erythromycin eingestuft wurden. (gstsvs.ch)
Chloramphenicol1
- ceftazidime sodium cefuroxime sodium celestone cena k cephalexin cephalothin sodium cephapirin sodium cephradine cephradine dihydrate cephulac ceptaz cerubidine cetacort cetamide chemdec dm chemdec chlor-trimeton chloral hydrate chloramphenicol chloramphenicol sodium succinate chlordiazachel chlordiazepoxide hydrochloride chlorofair chlorhexidine gluconate chloromycetin chloroprocaine hydrochloride chloroptic chloroptic s. (cleaningmygun.com)
Isolates3
- found in a 2009 study that cefoxitin disk assays correctly identified all 60 mecA-positive Staphylococcus aureus, or MRSA isolates, to be resistant to cefoxitin. (wikipedia.org)
- Cefoxitin Sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. (toku-e.com)
- Susceptibility to methicillin was phenotypically determined based on sensitivity of isolates to cefoxitin and oxacillin. (biomedcentral.com)
Cephalosporins2
- In randomized comparative studies, Cefoxitin for injection, USP and cephalothin were comparably safe and effective in the management of infections caused by gram-positive cocci and gram-negative rods susceptible to the cephalosporins. (wikidoc.org)
- Many infections caused by aerobic and anaerobic gram-negative bacteria resistant to some cephalosporins respond to cefoxitin for injection, USP. (wikidoc.org)
Sodium6
- The generic version of cefoxitin is known as cefoxitin sodium. (wikipedia.org)
- MEFOXIN contains approximately 53.8 mg (2.3 milliequivalents) of sodium per gram of cefoxitin activity. (rxlist.com)
- Each conventional vial contains sterile cefoxitin sodium, USP equivalent to 1 g, 2 g or 10 g cefoxitin. (rxlist.com)
- Cefoxitin Sodium, USP is the sodium salt of Cefoxitin, a cephamycin β-lactam second-generation cephalosporin that is resistant to β-lactamases. (toku-e.com)
- Cefoxitin Sodium is freely soluble in aqueous solution. (toku-e.com)
- Cefoxitin sodium is a 2nd generation cephalosporin that is FDA approved for the treatment of lower respiratory tract infections , urinary tract infection , gynecological infections , septicemia , bone and joint infections , and skin infections . (wikidoc.org)
Resistant6
- Cephamycin C was the first cephem discovered but while it was highly resistant to several beta-lactamases, as is its derivative cefoxitin, it was almost only effective against Gram negative bacteria. (wikipedia.org)
- As a cephamycin, cefoxitin is highly resistant to hydrolysis by some beta-lactamases, in part due to the presence of the 7-alpha-methoxy functional group (see skeletal formula above). (wikipedia.org)
- MRSA, or methicillin-resistant Staphylococcus aureus is a strain that has acquired resistance to cefoxitin via this gene. (wikipedia.org)
- Staphylococci that are resistant to methicillin and oxacillin should also be considered clinically resistant to cefoxitin even if they test susceptible by in vitro methods. (wikipedia.org)
- Major bacteria resistant to cefoxitin include: methicillin-resistant Staphylococcus aureus Enterococci Listeria monocytogenes Enterobacter sp. (wikipedia.org)
- Like many cephamycins, Cefoxitin is resistant to β-lactamases. (toku-e.com)
Mefoxin4
- Cefoxitin requires a prescription and as of 2010 is sold under the brand name Mefoxin by Bioniche Pharma, LLC. (wikipedia.org)
- Mefoxin (cefoxitin) is a cephalosporin antibiotic used to treat many kinds of bacterial infections, including severe or life-threatening forms. (rxlist.com)
- Our Mefoxin (cefoxitin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
- MEFOXIN (cefoxitin for injection) is a semi-synthetic, broad-spectrum cepha antibiotic sealed under nitrogen for intravenous administration. (rxlist.com)
Susceptibility3
- Interpretive criteria for determining susceptibility to cefoxitin via disk diffusion are greater than or equal to 22mm resulting in a "susceptible" result for Staphylococcus aureus and greater than or equal to 25mm for coagulase-negative staphylococci to be considered susceptible. (wikipedia.org)
- Variations in susceptibility to latamoxef (moxalactam) and cefoxitin within the Bacteroides fragilis group. (microbiologyresearch.org)
- Appropriate culture and susceptibility studies should be performed to determine the susceptibility of the causative organisms to Cefoxitin for injection, USP. (wikidoc.org)
Oxacillin1
- For the purposes of detecting bacterial strains with the mecC gene, which like mecA codes for a different PBP, cefoxitin is more reliable than oxacillin because mecC does not correlate as strongly with oxacillin resistance. (wikipedia.org)
Antibiotics2
- This PBP has a lower binding affinity for penicillin-based antibiotics such as cefoxitin and will continue to cross-link the peptidoglycan layers of the cell wall even in the presence of the beta-lactam antibiotics. (wikipedia.org)
- Cefoxitin may interact with antibiotics. (rxlist.com)
Antibiotic4
- Cefoxitin is a second-generation cephamycin antibiotic developed by Merck & Co., Inc. from Cephamycin C in the year following its discovery, 1972. (wikipedia.org)
- Cefoxitin is a beta-lactam antibiotic which binds to penicillin binding proteins, or transpeptidases. (wikipedia.org)
- Due, in part, to the unavailability of methicillin in the United States, cefoxitin has replaced methicillin for disk diffusion tests, which determine the sensitivity of a bacterial specimen to a given antibiotic. (wikipedia.org)
- Cefoxitin is a broad-spectrum antibiotic effective against several Gram-positive and Gram-negative bacteria. (toku-e.com)
Cephamycin2
- Cefoxitin, and the cephamycin family as a whole, served as a branching point and impulsed the discovery of more classes of beta-lactams. (wikipedia.org)
- Cefoxitin was discovered in 1972 and developed by Merck & Co. and Lilly from Cephamycin C. It was synthesized in order to broaden its spectrum. (toku-e.com)
Susceptible4
- Major bacterial strains susceptible to cefoxitin include: methicillin-susceptible Staphylococcus aureus Streptococcus sp. (wikipedia.org)
- Type cultures produced low levels of β-lactamase and were susceptible to cefoxitin, latamoxef, imipenem and the combination of benzylpenicillin and clavulanic acid. (microbiologyresearch.org)
- Cefoxitin for injection, USP is indicated for the treatment of serious infections caused by susceptible strains of the designated microorganisms in the diseases listed below. (wikidoc.org)
- Many infections caused by mixtures of susceptible aerobic and anaerobic bacteria respond to treatment with cefoxitin for injection, USP. (wikidoc.org)
Cephaloridine1
- Cephaloridine versus cephalothin: relation of the kidney to blood level differences after parenteral administration. (webmd.com)
Imipenem1
- However, cefoxitin is a better substrate than imipenem for beta-lactamases. (wikipedia.org)
Gram2
- Yet only cefoxitin retained its previous effectiveness against Gram negative bacteria, developed effectiveness against Gram positive bacteria, and resisted breakdown by beta-lactamase. (wikipedia.org)
- The usual adult dosage range of cefoxitin is 1 gram to 2 grams every six to eight hours. (rxlist.com)
Injection3
- Therefore, when Cefoxitin for injection, USP is used in the treatment of patients with pelvic inflammatory disease and C. trachomatis is one of the suspected pathogens, appropriate anti-chlamydial coverage should be added. (wikidoc.org)
- Cefoxitin for injection, USP has a high degree of stability in the presence of bacterial beta-lactamases, both penicillinases and cephalosporinases. (wikidoc.org)
- Cefoxitin for injection, USP is indicated for the prophylaxis of infection in patients undergoing uncontaminated gastrointestinal surgery, vaginal hysterectomy, abdominal hysterectomy, or cesarean section. (wikidoc.org)
Semi-synthetic1
- The scientists used chemically modified the compound to give cefoxitin, so titled due to its semi-synthetic nature. (wikipedia.org)
Effective1
- Like many cephamycins, Cefoxitin is particularly effective against anaerobic bacteria. (toku-e.com)
Results1
- Cefoxitin also yields more accurate results for disk diffusion tests. (wikipedia.org)
Drugs1
- Other drugs may interact with cefoxitin. (rxlist.com)
Cephamycins2
- and cephamycins such as cefoxitin. (nih.gov)
- CMY-11 β-lactamase genes from nine clinical isolates that were responsible for resistance to cephamycins (cefoxitin and cefotetan), amoxicillin, cephalothin and amoxicillin-clavulanic acid, were cloned and characterised. (elsevierpure.com)
Acquired resistance1
- MRSA, or methicillin-resistant Staphylococcus aureus is a strain that has acquired resistance to cefoxitin via this gene. (wikipedia.org)
Beta-lactamase2
- Yet only cefoxitin retained its previous effectiveness against Gram negative bacteria, developed effectiveness against Gram positive bacteria, and resisted breakdown by beta-lactamase. (wikipedia.org)
- Resistance to cefoxitin is primarily through hydrolysis by beta-lactamase, alteration of penicillin-binding proteins (PBPs), and decreased permeability. (nih.gov)
Cephaloridine1
- It is a semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of cephaloridine or cephalothin, but somewhat less potent. (shreejipharmainternational.com)
PBPs1
- By binding to PBPs, cefoxitin prevents the PBPs from forming the cross-linkages between the peptidoglycan layers that make up the bacterial cell wall, thereby interfering with cell wall synthesis. (wikipedia.org)
Hydrolysis1
- As a cephamycin, cefoxitin is highly resistant to hydrolysis by some beta-lactamases, in part due to the presence of the 7-alpha-methoxy functional group (see skeletal formula above). (wikipedia.org)
Bacteria4
- In the presence of cefoxitin, bacteria that make beta-lactamases will increase their production and secretion to cleave the beta lactam ring. (wikipedia.org)
- Another more efficient form of resistance to cefoxitin is provided by the mecA gene in bacteria. (wikipedia.org)
- determined that cefoxitin serves as an appropriate replacement for methicillin in determining if some bacteria display methicillin resistance. (wikipedia.org)
- Cefoxitin has activity in the presence of some beta-lactamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria. (nih.gov)
Penicillin2
- Cefoxitin is a beta-lactam antibiotic which binds to penicillin binding proteins, or transpeptidases. (wikipedia.org)
- This PBP has a lower binding affinity for penicillin-based antibiotics such as cefoxitin and will continue to cross-link the peptidoglycan layers of the cell wall even in the presence of the beta-lactam antibiotics. (wikipedia.org)