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  • strains
  • In subsequent transfer cycles of this plasmid, cefotaxime and cefoxitin resistance determinants segregated in contrast to the relative stability of plasmids derived from Klebsiella strains in subsequent transfer cycles. (springer.com)
  • bacterial cell wall
  • Cefotaxime impairs the bonds that hold the bacterial cell wall together. (netdoctor.co.uk)
  • Mode of action and Anti-microbial spectrum: Cefotaxime is an inhibitor of bacterial cell wall synthesis. (gbiosciences.com)
  • Cefotaxime is a cephalosporin, which acts by interference of synthesis of peptidoglycan of the bacterial cell wall. (mpbio.com)
  • Cefotaxime inhibits bacterial cell wall synthesis by binding to penic. (vwr.com)
  • Cefotaxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. (drugsupdate.com)
  • loading dose
  • Forty-seven patients received 2 g of cefotaxime as a continuous infusion over 24 h plus a loading dose of 1 g, while 46 patients received the drug intermittently (1 g three times daily). (bmj.com)
  • dosages
  • Dextrose Hydrous, USP has been added to adjust osmolality (approximately 1.7 g and 700 mg to the 1 g and 2 g cefotaxime dosages, respectively). (rxlist.com)
  • infections
  • Cefotaxime can also be given before certain types of surgery that are associated with an increased risk of infection, for example abdominal, bowel, heart or bone surgery, to help prevent infections after the operation. (netdoctor.co.uk)
  • In a prospective, randomized, double-blind study, we compared cefotaxime with nafcillin plus tobramycin in the treatment of serious bacterial infections. (annals.org)
  • We conclude that cefotaxime may be more effective and less toxic than nafcillin plus tobramycin for patients with serious bacterial infections. (annals.org)
  • describes
  • NDA 065292 describes CEFOTAXIME SODIUM , which is a drug marketed by Aurobindo Pharma , Aurobindo Pharma Ltd , Cephazone Pharma , Hospira Inc , Lupin , and Wockhardt , and is included in nine NDAs. (drugpatentwatch.com)
  • acid
  • For confirmation of ESBL production ceftazidime (30ug), ceftazidime + clavulanic acid combination disc (30/10ug) manufactured by HiMedia and cefotaxime (30ug) + cefotaxime clavulanic acid (30/10ug) prepared in laboratory were used. (thefreedictionary.com)
  • drug
  • Because tubular secretion is involved in the renal excretion of the drug, probenecid has been demonstrated in several species to prolong the serum half-life of cefotaxime. (elephantcare.org)
  • treatment
  • Therefore during treatment with Cefotaxime additional contraceptive methods should be used. (drugs.com)
  • If you are pregnant or are planning to become pregnant, your doctor has to determine if a treatment with Cefotaxime is suitable for you. (drugs.com)
  • A logistic regression analysis showed that treatment with cefotaxime was still associated with a higher response rate after adjusting for several potential confounding factors. (annals.org)