CDR2 and CDR3CDR3CDRsPeptideAntigenSpecificityHypervariableSequencesRepertoireGene segmentsImmuneAntibodiesChainsAntibodyTargetAmino acidsChosenPowerShownConstantMethodsHypervariable regionsAmino acid seqLoopsPeptidesReceptorsAntibodiesPortionsCorrespondImmunoglobulinsRecognitionTermDomainResponsible
CDR2 and CDR32
- There are three CDRs (CDR1, CDR2 and CDR3), arranged non-consecutively, on the amino acid sequence of a variable domain of an antigen receptor. (wikipedia.org)
- Investigate the T-cell immune repertoire by interrogating CDR1, CDR2, and CDR3 of the TCR beta chain. (thermofisher.com)
CDR33
- Within the variable domain, CDR1 and CDR2 are found in the variable (V) region of a polypeptide chain, and CDR3 includes some of V, all of diversity (D, heavy chains only) and joining (J) regions. (wikipedia.org)
- Within the TCRβ chain, the complementarity-determining region 1 (CDR1) and CDR2 loops of the TCR contact the MHC alpha-helices while the hypervariable complementary determining regions (CDR3) interact mainly with the peptide ( 1 , 2 ). (frontiersin.org)
- Target the complementarity-determining region 3 (CDR3) of the T-cell receptor (TCR) beta (β) chain to characterize immune status. (thermofisher.com)
CDRs4
- Complementarity-determining regions (CDRs) are part of the variable chains in immunoglobulins (antibodies) and T cell receptors, generated by B-cells and T-cells respectively, where these molecules bind to their specific antigen. (wikipedia.org)
- Since most sequence variation associated with immunoglobulins and T cell receptors are found in the CDRs, these regions are sometimes referred to as hypervariable regions. (wikipedia.org)
- Complementarity determining regions (CDRs), which are hypervariable in the Vα/β-chains have actual contact with antigens. (pharmacygyan.com)
- The EPO considers that the sequence claims must at least specify the sequence of the 6 CDRs (Complementarity-Determining Regions) involved in the interaction with the target. (patentepi.org)
Peptide8
- A peptide based on complementarity-determining region (CDR)-1 of a monoclonal murine anti-DNA Ab that bears the common idiotype, 16/6Id, was synthesized and characterized. (cancercurehere.com)
- The CDR1-structured peptide was also proven to prevent auto-Ab creation in BALB/c neonatal mice which were immunized afterwards with NGFR either pCDR1 or the pathogenic auto-Ab (7). (cancercurehere.com)
- In today's report, the power from the CDR1-structured peptide to immunomodulate SLE induced in BALB/c mice was examined. (cancercurehere.com)
- A set of standard tests are defined for the performance of peptide-TCR binding, including the detection of TCRs binding to a given peptide/antigen, choosing among a set of candidate peptides for a given TCR and determining whether any pair of TCR-peptide bind. (frontiersin.org)
- While both chains have been reported to be important to affect binding, we show here that for many TCR-peptide pairs the TCR's binding to target MHC-peptide can be determined with high accuracy using the β-chain only. (frontiersin.org)
- examined the mechanism of action underlying the anti-tumor effects of the complementarity-determining region (CDR) C36L1 synthetic peptide derived from the V L CDR1 of the C36 Fab fragment of the anti-vaccinia immunoglobulin. (cytoskeleton.com)
- 2015. A novel microtubule de-stabilizing complementarity-determining region C36L1 peptide displays anti-tumor activity against melanoma in vitro and in vivo . (cytoskeleton.com)
- β-chain CDR1 reacts with the C-terminal portion of the peptide. (pharmacygyan.com)
Antigen3
- The class hence determines the function triggered by an antibody after binding to an antigen, in addition to some structural features. (wikipedia.org)
- Each chain contains three complementarity-determining regions (CDR1-3), contributing to antigen specificity. (wyattmcdonnell.com)
- Recently, the amino acid sequences of the variable domain, which is involved in the antigen binding, has been determined through X-ray crystallography and Mass spectroscopy. (kjom.org)
Specificity2
- The V regions of the α/β-chains determine antigenic specificity by creating a three-dimensional pocket that recognizes immunogenic epitopes. (pharmacygyan.com)
- The specificity of T-cells is determined by the T-cell receptor (TCR), a heterodimer of alpha and beta protein chains. (elifesciences.org)
Hypervariable1
- Framework region Hypervariable region Abbas AK and Lichtman AH (2003). (wikipedia.org)
Sequences4
- Two peptides predicated on the sequences from the complementarity-determining locations (CDR) from the pathogenic murine monoclonal anti-DNA Ab (5G12) that bears the order CB-7598 16/6 Identification were synthesized. (cancercurehere.com)
- Therefore, in this study, the amino acid sequences of the heavy and light chain variable domains named as MassM2 were newly redesigned by aligning the amino acid sequences of the heavy and light chain variable domains determined by two methods mentioned above. (kjom.org)
- Depending on the newly determined variable heavy and light chain amino acid sequences of the MassM2 antibody, corresponding genes were designed, synthesized, and cloned into the pUC119 expression vector and then expressed in Escherichia coli as a recombinant MassM2 single chain variable fragment (ScFv) antibody. (kjom.org)
- The IMGT/V-QUEST reference directory sets are constituted by sets of sequences which contain the V-REGION , D-REGION and J-REGION alleles , isolated from the Functional and ORF allele IMGT reference sequences . (imgt.org)
Repertoire1
- To determine from a repertoire whether its host had been exposed to a target, computational tools that predict TCR-epitope binding are required. (frontiersin.org)
Gene segments1
- β-chains have 52 variable gene segments, two diversity gene segments, and 13 J region genes. (pharmacygyan.com)
Immune1
- The constant region at the trunk of the antibody includes sites involved in interactions with other components of the immune system. (wikipedia.org)
Antibodies3
- Antibodies are heavy (~150 k Da ) proteins of about 10 nm in size, [7] arranged in three globular regions that roughly form a Y shape. (wikipedia.org)
- For most functional antibodies, the heavy chain determines the light chain. (wyattmcdonnell.com)
- Among the recovered antibodies was TXG-0078, a public neutralizing mAb that binds the NTD supersite region of the coronavirus Spike protein and recognizes a diverse collection of alpha- and beta-coronaviruses. (bvsalud.org)
Chains1
- In the α-chains, CDR1 interacts with the N-terminal portion of the epitope. (pharmacygyan.com)
Antibody3
- A target region within the variable light chain or heavy chain of the first antibody is then identified. (patentpc.com)
- This is where the target region refers to a portion of the first antibody that has at least one amino acids difference from the same area in the related antibody. (patentpc.com)
- Each modified antibody contains at least one variable heavy or variable light-chain in its target region. (patentpc.com)
Target1
- The target region is altered by replacing a single amino acids residue. (patentpc.com)
Amino acids1
- The C region consists of 140 to 180 hydrophilic amino acids and continues to a short hinge region with cysteine residues that link the α-chain and the β-chain A transmembrane anchor unit, which consists of highly charged hydrophobic amino acids, is connected to a short cytoplasmic region. (pharmacygyan.com)
Chosen1
- A 22 cm2 region was chosen, and a 200 g/mL exact carbon copy of MHY-SLNs suspension system or MHY answer alone was put on the mouse pores and skin for two weeks in the MHY-SLNs and MHY answer organizations, respectively. (conferencedequebec.org)
Power4
- In one example, an electromagnetic field generator is disposed on a substrate and configured to deliver power via electromagnetic energy to a thin region proximate to (above) a surface of the substrate, wherein electromagnetic field intensity decreases significantly beyond the thin region. (patentsencyclopedia.com)
- andat least one electromagnetic field generator disposed on the substrate,wherein the at least one electromagnetic field generator, when energized, is configured to deliver power only to a localized area comprising a thin region proximate to the substrate. (patentsencyclopedia.com)
- 5. The apparatus of claim 1, wherein the at least one electromagnetic field generator is configured to deliver power to the thin region in an area parallel to a surface of the substrate having dimensions of approximately 8 millimeters by 8 millimeters. (patentsencyclopedia.com)
- 24. The apparatus of claim 1, wherein the power is delivered to the thin region via a magnetic field above the electrodes, and wherein the at least one electromagnetic field generator comprises a length of wire arranged in a serpentine pattern. (patentsencyclopedia.com)
Shown1
- Glycans in the Fc region are shown in black. (wikipedia.org)
Constant1
- In addition to V regions, each TCR has an invariant constant(C)region. (pharmacygyan.com)
Methods1
- Such methods and apparatus are particularly useful in a wide variety of processes involving chemical and/or physical interactions in connection with a sample of interest located in the thin region. (patentsencyclopedia.com)
Hypervariable regions1
- It includes hypervariable regions ( COMPLEMENTARITY DETERMINING REGIONS ) and framework regions. (lookformedical.com)
Amino acid seq3
- Synthetic peptides A peptide (designated hCDR1) with the amino acid sequence GYYWSWIRQPPGKGEEWIG, based on the complementarity determining region 1 (CDR1) of the human monoclonal anti-DNA autoantibody that bears the 16/6Id, was synthesized (solid phase synthesis by F-moc chemistry) by Polypeptide Laboratories (LA, USA). (kidztrainer.com)
- That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. (lookformedical.com)
- In addition, a stretch of amino acid sequence also known as the framework region. (medicalbiochemist.com)
Loops3
- Fibroblast growth factor receptors (FGFRs) have common structural features and consist of an extracellular ligand-binding domain containing 2 or 3 Ig-like loops and a unique acid region, a trans-membrane domain, and the cytoplasmic region, which contains the tyrosine kinase catalytic domain and kinase insert. (justia.com)
- The MD simulations indicate that the mutation increased conformational diversity in complementarity-determining region loops and thereby enhanced the association rate. (bvsalud.org)
- Gaps in the CDR1-IMGT and CDR2-IMGT (less than 12 and 10 amino acid long, respectively) are put at the top of the CDR-IMGT loops, as in IMGT/3Dstructure-DB (gaps shown as dashes, in the table below). (imgt.org)
Peptides1
- Two peptides, based on the sequence of the complementarity determining regions (CDR) 1 and 3 of the pathogenic murine anti-DNA 16/6Id were synthesized. (kidztrainer.com)
Receptors1
- These regions are also present in other members of the immunoglobulin superfamily, for example, T-cell receptors ( RECEPTORS, ANTIGEN, T-CELL ). (nih.gov)
Antibodies3
- No functional activity was reported for the pathogenic heavy chain antibodies in these patients, as these proteins were shown to bear extensive internal deletions in the variable (VH) and the first constant region (CH1) domains. (frontiersin.org)
- For most functional antibodies, the heavy chain determines the light chain. (wyattmcdonnell.com)
- Antibodies which react with the individual structural determinants (idiotopes) on the variable region of other antibodies . (lookformedical.com)
Portions1
- The C regions, found in the middle and C-terminal portions of the H and L chains, are relatively more conserved. (medicalbiochemist.com)
Correspond1
- Structural analysis of TCR-pMHC complexes indicates conserved sites in TCR CDR1 and 2 of Vα and Vβ that correspond to sites on the MHC α-helices ( 9 ), which can explain these biases of selection. (frontiersin.org)
Immunoglobulins1
- Identify the region of electrophoresis that consists of these major immunoglobulins. (medicalbiochemist.com)
Recognition1
- 12) The variable heavy and light chains make up the antigen recognition region. (medicalbiochemist.com)
Term1
- coord NIM with CELL NUCLEUS /metab (IM) + substance /metab (IM) HN - 2001 BX - Nuclear Export BX - Nuclear Import BX - Nuclear Transport MH - Acute Toxicity Tests UI - D023382 MN - E5.940.74 MS - Experiments designed to determine the potential toxic effects of one-time, short-term exposure to a chemical or chemicals. (nih.gov)
Domain2
Responsible1
- 8) The hypervariable complementarity determining region (CDR) is responsible for which of the following function? (medicalbiochemist.com)