Domain I is conserved in evolution from yeast to human species and is homologous to the transcription factors elongin A and CRSP70. (embl.de)
Xenopus3
The TFIIIA in Xenopus was the first zinc finger protein discovered. (wikipedia.org)
To investigate possible functions of CCCH proteins in early development of Xenopus, we isolated four Xenopus cDNAs encoding members of this class. (embl.de)
3. Miller J,McLachlan A D,Klug A. Repetitive zinc-binding domains in the protein transcription factor Ⅲ A from Xenopus oocytes [J].EMBO J,1985,4(6):1609-1614. (nefu.edu.cn)
Genes1
Human transcription factor IIIC (hTFIIIC) is a multisubunit complex that mediates transcription of class III genes through direct recognition of promoters (for tRNA and virus-associated RNA genes) or promoter-TFIIIA complexes (for the 5S RNA gene) and subsequent recruitment of TFIIIB and RNA polymerase III. (embl.de)
Polymerase6
We have previously solved the structures of domains II and III, which stimulate arrested polymerase II elongation complexes in order to resume transcription. (embl.de)
Domain I also interacts with the transcriptionally active RNA polymerase II holoenzyme and therefore, may have a function unrelated to the previously described transcription elongation activity of TFIIS. (embl.de)
The RPB9 subunit of RNA polymerase II regulates transcription elongation activity and is required for the action of the transcription elongation factor, TFIIS. (embl.de)
The individual zinc ribbon domains, in isolation or in combination, could not stimulate transcription by a polymerase lacking RPB9, pol IIDelta9. (embl.de)
For example, transcript elongation factor TFIIS is highly conserved among eukaryotes, and yet the TFIIS protein from Saccharomyces cerevisiae cannot function with mammalian RNA polymerase II and vice versa. (embl.de)
The levels of CBCVd in tobacco were enhanced in plant hybrids expressing CBCVd cDNAs and either the tobacco or hop variant of TFIIIA-7ZF, a viroid-mediated splicing derivative of transcription factor IIIA, which is important for viroid replication by DNA-dependent RNA polymerase II. (bvsalud.org)
TFIIIB2
We describe the cognate cDNA cloning and characterization of two subunits (hTFIIIC63 and hTFIIIC102) that are present within a DNA-binding subcomplex (TFIIIC2) of TFIIIC and are related in structure and function to two yeast TFIIIC subunits (yTFIIIC95 and yTFIIIC131) previously shown to interact, respectively, with the promoter (A box) and with a subunit of yeast TFIIIB. (embl.de)
Gene-specific factor TFIIIA interacts with DNA and acts as an adaptor for TFIIIC-promoter interactions. (bvsalud.org)
Proteins6
Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev". Proceedings of the National Academy of Sciences of the United States of America. (wikipedia.org)
Many proteins involved in eukaryotic transcription are similar in function and in sequence between organisms. (embl.de)
Proteins containing CCCH Znf domains include Znf proteins from eukaryotes involved in cell cycle or growth phase-related regulation, e.g. human TIS11B (butyrate response factor 1), a probable regulatory protein involved in regulating the response to growth factors, and the mouse TTP growth factor-inducible nuclear protein, which has the same function. (embl.de)
Tristetraprolin (TTP), the prototype of a class of CCCH zinc finger proteins, is a phosphoprotein that is rapidly and transiently induced by growth factors and serum in fibroblasts. (embl.de)
Zinc finger proteins constitute a large family of transcription factors and numerous members of them play diverse roles in many biological processes, including plant growth, development and stress responses. (nefu.edu.cn)
In mice, rapamycin treatment increases expression of histone proteins and Wdfy3 transcription, and alters chromatin organisation in the small intestine, suggesting the mTORC1-histone axis is at least partially conserved in mammals and may offer new targets for anti-ageing interventions. (sdbonline.org)
Mammalian1
Domain III has previously been shown to be readily exchanged between mammalian and yeast factors. (embl.de)
IIIA1
Transcription factor IIIA is a protein that in humans is encoded by the GTF3A gene. (wikipedia.org)
Zinc3
Mutations in the N-terminal zinc ribbon had little effect on transcription activity. (embl.de)
By contrast, mutations in the acidic loop that connects the second and third beta-strands of the C-terminal zinc ribbon were completely inactive for transcription. (embl.de)
5. Kielbowicz-Matuk A. Involvement of plant C 2 H 2 -type zinc finger transcription factors in stress responses[J].Plant Sci,2012,185-186:78-85. (nefu.edu.cn)
Yeast1
6. Lippuner V,Cyert M S,Gasser C S. Two classes of plant cDNA clones differentially complement yeast calcineurin mutants and increase salt tolerance of wild-type yeast[J].J Biol Chem,1996,271:12859-12866. (nefu.edu.cn)
Protein2
The mouse TTP protein is induced by growth factors. (embl.de)
Another protein containing this domain is the human splicing factor U2AF 35kDa subunit, which plays a critical role in both constitutive and enhancer-dependent splicing by mediating essential protein-protein interactions and protein-RNA interactions required for 3' splice site selection. (embl.de)
Transcriptional1
2. Golldack D,Lüking I,Yang O. Plant tolerance to drought and salinity:stress regulating transcription factors and their functional significance in the cellular transcriptional network[J].Plant Cell Rep,2011,30(8):1383-1391. (nefu.edu.cn)
RRNA1
Our findings provide new insights into the transcription initiation complex assembly on the 5S rRNA promoter and allow us to directly compare Pol III and Pol II transcription adaptations. (bvsalud.org)
Plant1
1. Singh K,Foley R C,Onate-Sanchez L. Transcription factors in plant defense and stress responses[J].Curr Opin Plant Biol. (nefu.edu.cn)
Sequence1
Despite the sequence similarities, there are many factors that do not function across species. (embl.de)
Domains2
TFIIS is a transcription elongation factor that consists of three domains. (embl.de)
Mapping of domains required for transcription elongation. (embl.de)
Function2
To elucidate the relationship between the structure and transcription elongation function of RPB9, we initiated a mutagenesis study on the Saccharomyces cerevisiae homologue. (embl.de)
Recent evidence suggests that a physiological function of TTP is to inhibit tumor necrosis factor alpha secretion from macrophages by binding to and destabilizing its mRNA (Carballo, E., Lai, W.S., Blackshear, P.J., 1998. (embl.de)
Complementary DNA1
Complementary DNA (cDNA) clones corresponding to maternal mRNAs localized to specific regions of the Xenopus laevis egg have been previously identified and cloned [Rebagliati et al. (embl-heidelberg.de)
Zinc finger1
A20 is a cytoplasmic zinc finger protein that inhibits nuclear factor kappa-B activity and tumor necrosis factor (TNF)-mediated programmed cell death. (biomedcentral.com)
Gene2
Different histone variants can contribute to distinct or unique nucleosomal architectures, which could potentially be exploited to regulate nuclear functions such as transcription, gene silencing, replication or recombination. (biomedcentral.com)
The TFIIIA-7ZF variants can change the tobacco morphogenesis if expressed in leaves and shoots. (bvsalud.org)
These results suggest that Rib and Lola act as dual-function transcription factors to cooperatively regulate embryonic gonad morphogenesis. (sdbonline.org)
Tumor1
To reveal the molecular role of OPTN in muscle atrophy, we used cultured C2C12 myotubes treated with tumor necrosis factor-like inducer of apoptosis (TWEAK) as an in vitro model of muscle atrophy. (bvsalud.org)
Bind1
The first reported member was PLATZ1, which was isolated from pea ( Pisum sativum ) [ 10 ] and shown to bind nonspecifically to A/T-rich sequences and repress transcription. (biomedcentral.com)
Specific2
In yeast, the RNAPIII transcription complex requires three transcription factors in addition to Pol III: two general transcription factors, TFIIIB and TFIIIC, and a specific transcription factor, TFIIIA, which is only required for the synthesis of 5S rRNA [ 14 ]. (biomedcentral.com)
This enabled study of specific isoforms with respect to previously characterized roles for Lola and to demonstrate a specific function for one variant in axon guidance via activation of the microtubule-associated factor Futsch . (sdbonline.org)
Common1
As the main common factor showing the differential up-regulation in shoot and anther tissues, a LITTLE ZIPPER 2-like transcription factor was found. (bvsalud.org)