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  • genome
  • the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage. (vwr.com)
  • proteins
  • Shortly after it begins, this enzyme - which is called Pol II for short - pauses, and it only starts again after it recruits other proteins, including one called CDK9. (elifesciences.org)
  • residues
  • Synthetic peptide conjugated to KLH derived from within residues 350 to the C-terminus of Human Cdk9. (abcam.com)
  • cyclin depende
  • Right here, using this process we confirm the part of HDACs, proteasomal regulators and MAPK in erythroid enucleation and expose a new part for Cyclin-dependent kinases, specifically CDK9, in this technique. (leafbioscience.com)
  • targets
  • We show that miR-191 represses proliferation in primary human fibroblasts, identify multiple proto-oncogenes as novel miR-191 targets, including CDK9, NOTCH2, and RPS6KA3, and present evidence that miR-191 extensively mediates target expression through coding sequence (CDS) pairing. (stanford.edu)
  • elongation
  • A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast. (mssm.edu)
  • Genes
  • According to Probiodrug AG, CDK9 , which has been implicated in the transcriptional regulation of genes involved in proliferation and inflammation, is a promising target for the treatment of both cancer and inflammatory diseases. (thefreedictionary.com)
  • complex
  • In addition, the CDK9/cyclin T2a complex promotes muscle differentiation and enhances the function of some myogenic regulatory factors. (umbc.edu)
  • This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with CDK9 and cyclin T, which suggested a possible involvement of this protein in AIDS. (kenresearch.com)
  • enzyme
  • Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition. (mssm.edu)
  • pack
  • We know that many of the CDK9 Raw pack are Staffordshire Bull Terriers and that their loving and responsible owners are instrumental in helping change perceptions about this breed- we salute you! (cdk9raw.com.au)
  • cancer
  • For instance, CDK7 is overexpressed in some types of breast cancer, and CDK9 is overexpressed in pancreatic cancer. (ntrc.nl)