Point MutationMutation, MissenseMutationCyclin-Dependent KinasesCyclin-Dependent Kinase 2Cyclin-Dependent Kinase 5Cyclin-Dependent Kinase 4Frameshift MutationMolecular Sequence DataGerm-Line MutationCDC2-CDC28 KinasesBase SequenceAmino Acid SequencePhosphorylationCell LineCyclin-Dependent Kinase 6CyclinsCDC2 Protein KinaseTransfectionPedigreeCell CycleProtein-Serine-Threonine KinasesCell Cycle ProteinsTranscription FactorsSignal TransductionProtein BindingCell Line, TumorDNA-Binding ProteinsRNA, MessengerGene ExpressionMice, TransgenicPolymerase Chain ReactionExonsAmino Acid SubstitutionProto-Oncogene ProteinsMutation RatePhenotypeNuclear ProteinsHeterozygoteCyclin ECyclin-Dependent Kinase Inhibitor p27Protein Structure, TertiaryMutagenesis, Site-DirectedCells, CulturedCyclin-Dependent Kinase 9DNA PrimersBlotting, WesternApoptosisPromoter Regions, GeneticAllelesDNA Mutational AnalysisGene Expression RegulationG1 PhaseCarrier ProteinsTranscription, GeneticMutagenesisPolymorphism, Single-Stranded ConformationalReverse Transcriptase Polymerase Chain ReactionGene Expression Regulation, NeoplasticSequence Homology, Amino AcidMembrane ProteinsBinding SitesCyclin D1Cloning, MolecularTumor Suppressor ProteinsRecombinant Fusion ProteinsCell DivisionCell ProliferationTumor Suppressor Protein p53Sequence Analysis, DNASaccharomyces cerevisiaeGenotypeHeLa CellsHomozygoteTumor Cells, CulturedGene DeletionRecombinant ProteinsGenes, DominantImmunohistochemistrySequence DeletionEscherichia coliCyclin-Dependent Kinase Inhibitor p21RNA, Small InterferingUp-RegulationS PhasePlasmidsCodon, NonsenseSaccharomyces cerevisiae ProteinsMitosisCyclin-Dependent Kinase 8Enzyme ActivationSuppression, GeneticDown-RegulationSequence AlignmentDNARNA InterferenceCell NucleusGenes, p53COS CellsNerve Tissue Proteins