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  • cyclin-depend
  • Indianapolis, Indiana-based global pharmaceuticals specialist Eli Lilly and Company's (NYSE: LLY) Phase 3 JUNIPER study evaluating Verzenio (abemaciclib), a cyclin-dependent kinase 4 and CDK6 inhibitor, as monotherapy in KRAS-mutated, advanced non-small lung cancer (NSCLC) did not meet its primary endpoint of overall survival (OS), the company said. (thefreedictionary.com)
  • CDK6(Cyclin-dependent kinase 6) is involved in initiation and maintenance of cell cycle exit during cell differentiation and it prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types.The range of the molecular weight is 34-50 KDa (PMID: 23563707, 17420273, 8114739). (ptglab.com)
  • Recognizes cyclin-dependent kinase 6 (cdk6), also known as PLSTIRE, at 40kD. (lsbio.com)
  • The latest report Cyclin Dependent Kinase 6 - Pipeline Review, H2 2017, outlays comprehensive information on the Cyclin Dependent Kinase 6 (Cell Division Protein Kinase 6 or Serine/Threonine Protein Kinase PLSTIRE or CDK6 or EC 2.7.11.22) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. (reportsnreports.com)
  • Furthermore, this report also reviews key players involved in Cyclin Dependent Kinase 6 (Cell Division Protein Kinase 6 or Serine/Threonine Protein Kinase PLSTIRE or CDK6 or EC 2.7.11.22) targeted therapeutics development with respective active and dormant or discontinued projects. (reportsnreports.com)
  • Two genes, CDK6 (cyclin-dependent kinase 6) and XRCC1, were significantly associated with DN after Bonferroni correction for multiple testing (P=0.0001 and 0.00025, respectively), whereas neither gene was significantly associated with CMM. (univaq.it)
  • hematopoietic
  • Since Runx transcription factors play central roles in hematopoietic, neuronal and osteogenic lineages, this novel, noncanonical Cdk6 function may control terminal differentiation in multiple tissues and cell types. (embopress.org)
  • pathway
  • Hh pathway targets and Cdk6 (red) are enriched in Hh-associated medulloblastoma. (jci.org)
  • mutations
  • The technology has already been successfully utilised to find key cancer mutations, including amplifications in ERBB2 (HER2/neu), MET and CDK6 , in cancer patients' blood. (thefreedictionary.com)
  • The findings are relevant to human patients: Tumors with low levels of CDK6 have mutations in TP53 significantly more often than expected. (aacrjournals.org)
  • CDKN2A
  • Associations for CDK6 SNPs were stronger in CDKN2A mutation-positive families (rs2079147, P interaction =0.0033), whereas XRCC1 SNPs had similar effects in mutation-positive and -negative families. (univaq.it)
  • expression
  • B ) Quantitative reverse-transcriptase PCR (qRT-PCR) demonstrates enrichment of Gli1 and enrichment of Cdk6 expression in Hh-associated medulloblastoma (blue) relative to age- and sex-matched littermate cerebella (gray). (jci.org)
  • MicroRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma. (thefreedictionary.com)
  • suggest
  • These results suggest that CDK6 antagonists may be a promising therapeutic approach for Hh-associated medulloblastoma in humans. (jci.org)
  • function
  • Cells lacking CDK6 kinase function are required to mutate TP53 (encoding p53) to achieve a fully transformed immortalized state. (aacrjournals.org)