Tumor Suppressor Protein p53Sodium-Phosphate Cotransporter ProteinsCyclin-Dependent Kinase Inhibitor p21Proto-Oncogene Proteins c-mdm2PhosphorylationCell Line, Tumorp38 Mitogen-Activated Protein KinasesSignal TransductionApoptosisCyclin-Dependent KinasesProteasome Endopeptidase ComplexCyclin-Dependent Kinase 2Cyclin-Dependent Kinase 5Cyclin-Dependent Kinase 4Molecular Sequence DataProteolysisCell LineUbiquitinAmino Acid SequenceCDC2-CDC28 KinasesBiodegradation, EnvironmentalCells, CulturedProtein BindingUbiquitinationUbiquitin-Protein LigasesMutationCell Cycle ProteinsCell CycleKineticsCDC2 Protein KinaseCyclinsProtein-Serine-Threonine KinasesCyclin-Dependent Kinase 6Cysteine EndopeptidasesRNA, MessengerUbiquitinsBase SequenceHeLa CellsMultienzyme ComplexesTime FactorsModels, BiologicalCyclin-Dependent Kinase Inhibitor p27DNA-Binding ProteinsBlotting, WesternEnzyme ActivationG1 PhaseTranscription, GeneticCarrier ProteinsProtein Processing, Post-TranslationalNuclear ProteinsTranscription FactorsEnzyme InhibitorsProtein TransportRecombinant Fusion ProteinsGene Expression RegulationCyclin-Dependent Kinase 9HydrolysisEndoplasmic Reticulum-Associated DegradationCyclin ERecombinant ProteinsSaccharomyces cerevisiae ProteinsBinding SitesRNA, Small InterferingCell NucleusMice, KnockoutProto-Oncogene ProteinsSubstrate SpecificitySaccharomyces cerevisiaeDown-RegulationFibroblastsMice, Inbred C57BLRNA InterferenceCalciumProteinsTumor Cells, CulturedS PhaseHEK293 CellsMembrane ProteinsTumor Suppressor ProteinsF-Box ProteinsImmunoprecipitationCell DivisionEndoplasmic ReticulumImmunoblottingMitosisDose-Response Relationship, DrugPeptide HydrolasesRNA StabilityCysteine Proteinase InhibitorsCyclin BProteasome InhibitorsAutophagyEscherichia coliHydrogen-Ion ConcentrationBacterial ProteinsPlasmidsProtein Structure, TertiaryCyclin-Dependent Kinase 8Protein StabilityCell Proliferation