Loading...
  • CDKN1B
  • CDK2 associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). (abcam.com)
  • regulate
  • With this new understanding of the biology driven by critical dual functions of CDK2, the cancer community can focus on ways to regulate a mechanism that the cell contains to prevent damaged genetic messages from being inherited and spread in proliferating tumor cells. (rxpgnews.com)
  • genes
  • If the cell has minor alterations in the DNA code that can be repaired, those repairs are made," says first author Haojie Huang, Ph.D. "If the genetic message cannot be repaired, our studies show that CDK2 can initiate the steps necessary for cells to order the production of genes involved with cell death, and the errant cell dies without propagating its damaging genetic message to progeny cells of its own. (rxpgnews.com)
  • induces
  • Cyclins E1 and E2 bind and activate the catalytic activity of CDK2, and overexpression of cyclin E transforms immortalized cells in culture, induces chromosome instability, and stimulates tumor formation in transgenic mice ( 1 - 4 ). (aacrjournals.org)
  • bind
  • In its inactive form, Cdk2 cannot bind substrate because the entrance of its active site is blocked by the T-loop. (wikipedia.org)